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<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9FQZ3</accession>
    <name>E9FQZ3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_309852</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX90068">
        <property type="protein sequence ID" value="EFX90068"/>
        <property type="gene ID" value="DAPPUDRAFT_309852"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309852"/>
    <dbReference type="HOGENOM" id="CLU_1769911_0_0_1"/>
    <dbReference type="OrthoDB" id="878996at2759"/>
    <dbReference type="PhylomeDB" id="E9FQZ3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX90068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="147" mass="15874" checksum="82D272AB72FEFE20" modified="2011-04-05" version="1">MSLVGCGNYIAFDIPSFYEESLNSSSLSTSSNAVLDGSWSNCDGSLNELKTRSLPSWARNKPPIRSAQQHNSRHVNADQKKDGRCAVPIIGSKRSHHGLRHDAAAIMAINKTAKTTAVRDNGDNLSGRVSLVGHNDAVIVFNERTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRU7</accession>
    <name>E9FRU7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-related protein Rab</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_39774</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">The small GTPases Rab are key regulators in vesicle trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX89909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89909"/>
    <dbReference type="EnsemblMetazoa" id="EFX89909">
        <property type="protein sequence ID" value="EFX89909"/>
        <property type="gene ID" value="DAPPUDRAFT_39774"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_39774"/>
    <dbReference type="eggNOG" id="KOG4423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_6_1"/>
    <dbReference type="InParanoid" id="E9FRU7"/>
    <dbReference type="OMA" id="SACIIMF"/>
    <dbReference type="OrthoDB" id="1240760at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04107">
        <property type="entry name" value="Rab32_Rab38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030697">
        <property type="entry name" value="Rab29/Rab38/Rab32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX89909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="175" mass="20429" checksum="A1F38F3ACC5D4559" modified="2011-04-05" version="1">MNFTKLEYNRATEKLFKVIIIGDPGVGKTSFIRRYVQNAFRGDYKATIGVDFALKIVRWSENQTIKLQLWDIAGQERFTWMTRVYYKEAQGCIIMFDLTSRNSFENAVKWKKDVDSKCVLEDGAPVPCMLLANKCDLRQREVDQWEIETLCREHSFIGWTETSAKDDLMVGDCMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRZ9</accession>
    <name>E9FRZ9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_189944</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90399"/>
    <dbReference type="EnsemblMetazoa" id="EFX90399">
        <property type="protein sequence ID" value="EFX90399"/>
        <property type="gene ID" value="DAPPUDRAFT_189944"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_189944"/>
    <dbReference type="eggNOG" id="KOG3103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074741_2_0_1"/>
    <dbReference type="InParanoid" id="E9FRZ9"/>
    <dbReference type="OMA" id="GINTIGC"/>
    <dbReference type="OrthoDB" id="1457080at2759"/>
    <dbReference type="PhylomeDB" id="E9FRZ9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="157"/>
            <end position="174"/>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="287" mass="30464" checksum="07B117B87AB1160B" modified="2011-04-05" version="1">MANPNDPNYYYGQSAGMAQPGYGWGDANQGEGISFDMDSNFGQEQHFQSFDYSQTSAHTSTIPDTSTSAGLYPPLQQAYESSYIGSPPTVYGGQQFLNPNASSFPASTVASSGTGFDDEPPLLEELGINPDHIFQKTLAVLNPMRETDASILQDTDLAGPLAFVLAFGGFLLLSGKVHFSYIYGIGVLGCLAIYAMLNLMAVSGVSIGVTVSVLGYCLLPMVALSGISILISLQGLLGIVLTTLAILWCSISASKLFVTALTMDHQQPLVAYPCAMLYGVFALLTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="661" mass="71115" checksum="EC4F910782261634" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUP8</accession>
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        <submittedName>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX88767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="395" mass="45274" checksum="CAADD7BDF051DC13" modified="2011-04-05" version="1">MNPNNPQHLMGSYPPHYFHVNPASLNWQWNQAMPGPSTLRGNFIHVNPAFFQTNVAPPPELPNPKRIIVNPKFFPHVQPERNTGTSSASHEVKNVEIIPAVLRDKAPNLNRVVIHEETKEKKQPIMALNSHNSQPIAQHHMKPSPIRHISERRKLTKMDFINQPMRSKYKWRKMESPLKAIATKHAYKLVRKSVVKSPKLASLSTHRAQFHASRLLTPPKFTSTPTETQPPINSRFKLDNRVTKNKKKATKSSSPRMSLPKIIQNKYRLIRNKCWKSKNLTLTKIGINRSIINHRSIVSRSVVNRSFTNFKSPVCRPMAHHSSRLQRLALVIKPNKSIKKTKTTKSKTRKRYYDDEAKTKPDDEVLDDVDVEIAEKPLGPKNRTPIGALPSFITL</sequence>
</entry>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="55"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX87488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="320" mass="37572" checksum="2F31DF92C28CF050" modified="2011-04-05" version="1">MEDLSKLLLEERAHSEQFKANFIQLKIEFDKLVTENHRLNDEILKFKEYKPEEPNEVLKRKLKNAEKELQGKDLLIASLQEKFHTINESLKEKLHHDKNYISRIASTENALEQTKMLLSNLQLETSVLVKNIEHSRKTDEQDHQRDLMTLADRCAKSDHERRLISRQVIKATTKAKKTTEMLKQENGLLSFTITKLKESMDKVCWEKSELSSQLETLKVQYGQNHGEMIMQIRNLECETAKLESKCHALERNIQEALREKEKAILAFQAAENEESKLRGNLCAIEMKFEKVTDQFKRDLEHKDHINNLEVQELKKNLHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9FY94</accession>
    <name>E9FY94_DAPPU</name>
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        <recommendedName>
            <fullName evidence="1">Lipocln_cytosolic_FA-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_311899</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87816">
        <property type="protein sequence ID" value="EFX87816"/>
        <property type="gene ID" value="DAPPUDRAFT_311899"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_311899"/>
    <dbReference type="eggNOG" id="KOG4824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068449_2_5_1"/>
    <dbReference type="InParanoid" id="E9FY94"/>
    <dbReference type="OMA" id="QGSANYW"/>
    <dbReference type="OrthoDB" id="1631943at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocln_cytosolic_FA-bd_dom" evidence="1">
        <location>
            <begin position="15"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX87816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="102" mass="11387" checksum="4019802545B1A72D" modified="2011-04-05" version="1">MRSTTTGTVRHVEPPNGKLNVVFSGDPTQGSANYWILGTDYTSYSVVWSCMHFGIEPINTRIAWVLTREQHPTNATIDAALDVLKKNGIDQSKLRLTNQHNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9G0J8</accession>
    <name>E9G0J8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_192571</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX86916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86916"/>
    <dbReference type="EnsemblMetazoa" id="EFX86916">
        <property type="protein sequence ID" value="EFX86916"/>
        <property type="gene ID" value="DAPPUDRAFT_192571"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_192571"/>
    <dbReference type="eggNOG" id="KOG3926">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065667_0_0_1"/>
    <dbReference type="InParanoid" id="E9G0J8"/>
    <dbReference type="OMA" id="CTSMSEA"/>
    <dbReference type="OrthoDB" id="623008at2759"/>
    <dbReference type="PhylomeDB" id="E9G0J8"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="FBX25/32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123">
        <property type="entry name" value="PTHR13123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="SSF81383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX86916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="361" mass="41260" checksum="5C8C33510CCD81A7" modified="2011-04-05" version="1">MPFYAKDWRSPGESWIKTEDGWEKLKVLETNRKRLISDDGVFCRSADDDKENCALDNSPEPDKTKGCVPPHCQITLKCTKEVAGFNGLSDALRRLDFRSAVHDHRRFPYTAKLLELLLCQHRITNLSGCAQKSVLNVLEEIAVQAQGSQQNMHVLVKLLTDLRTIVRGDSWWGTPLGSSQLWGKHVRTIDRIGAIASSILPGHNDGDDKPKFEDLPEECVREILFRLADHRDLLSAAEACGVVQKLSAEQRLWKRLCRFHFTPVQINDDISQQTGGNQSNLETDWEDVFHRARRLFGLREDYAEILHLCRNCRCLFWKTYGHPCIVDHQQTDNKSDEPSSCDPEAFYVPVPPQAFLKFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1H6</accession>
    <name>E9G1H6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_97492</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86499">
        <property type="protein sequence ID" value="EFX86499"/>
        <property type="gene ID" value="DAPPUDRAFT_97492"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_97492"/>
    <dbReference type="eggNOG" id="ENOG502S6YH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_931440_0_0_1"/>
    <dbReference type="InParanoid" id="E9G1H6"/>
    <dbReference type="OMA" id="GPYLEND"/>
    <dbReference type="OrthoDB" id="1517204at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX86499.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="299" mass="33143" checksum="E3A2BF756293A34E" modified="2011-04-05" version="1">MLAYVKKIHRHSDELLHLALILSLIRVDPESYLGLGLGRSNSIRGSFHNVTMGDTWAHAPSDFHHGFMSNLPDIPYLHPKSMEASLTQYQEELIEDLNDLGRYTSILPPRSPRTITAYLLDDSSLNRDSNLPNVNTVSPVVASSSSSLIAATVSSQSHHDELLDSIQPQSPPESSIQDDASVLSLEDADLIEILWKQDIDIGVPRDHFLFPEDQESSGEDVDTATLKDKLDLKGEQKEKTKHGENKNDEDPPDKSPSDDDPWAGLSYRIDDETGCRISSTTLHPSVYGFIECQVCAAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9G253</accession>
    <name>E9G253_DAPPU</name>
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        <recommendedName>
            <fullName evidence="3">Erf4 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="4" type="ORF">DAPPUDRAFT_92217</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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        </lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="EnsemblMetazoa" id="EFX86187">
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        <property type="gene ID" value="DAPPUDRAFT_92217"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_92217"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="Golgin_A_7/ERF4"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX86187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="155" mass="17610" checksum="1D7DC09A322C6E36" modified="2011-04-05" version="1">MASKKKQTTPTDDFSARGAPSPPTQKVFIQRDYSEGTQVRFQPKFPSELEGKIEREKFEYTLNTLNEVYAEAEKMSCSSCCEGCFACLTAYLLYCCSDTHFEKCLKKVAKFIIEQNERVYVPRGLLIIDPVERGLRVIEICIFSDNPASTPARNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9G364</accession>
    <name>E9G364_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_31747</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX86044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86044"/>
    <dbReference type="EnsemblMetazoa" id="EFX86044">
        <property type="protein sequence ID" value="EFX86044"/>
        <property type="gene ID" value="DAPPUDRAFT_31747"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_31747"/>
    <dbReference type="eggNOG" id="KOG3528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006629_1_1_1"/>
    <dbReference type="InParanoid" id="E9G364"/>
    <dbReference type="OMA" id="FRENECI"/>
    <dbReference type="OrthoDB" id="908238at2759"/>
    <dbReference type="PhylomeDB" id="E9G364"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0043296">
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    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0045197">
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    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="149"/>
            <end position="221"/>
        </location>
    </feature>
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        <location>
            <begin position="280"/>
            <end position="358"/>
        </location>
    </feature>
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        <location>
            <begin position="80"/>
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        </location>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
    <sequence length="377" mass="41186" checksum="79E54B95977EB527" modified="2011-04-05" version="1" fragment="single">LGLLVQGVEPGGRIYRDGRIAVHDRIVEINSHPLKDVPFHRAQELFRNALQVYFFFSYHILPISRDLRLRIVKSNGEVNRGPASDQLDEMTQQQQQQPQLIQTQQQQAPPSRVAAVSPTRKTPAVVPGTGRASNALMTVSTRKIGKKLDLELTKGHEGLGFSVTTRDNPAGGLCPIYIKNILPRGAAIEDGRLRSGDRLLEVNGVEMTGKTQSEVVSLLRNIPSGGVARLLISRQETEEEIQQSNQLQNQQVQSSSQLQSASEESLLLLPWKQREILTLDIPVHDTEKAGLGISVKGKTTSSSGNGTSDLGIFIKSVLHGGAASRDGRLCTNDQLLHVNGVSLQGRSNTEAMEGLRRAVHQEGPKPGHITLTVARKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9G439</accession>
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        <recommendedName>
            <fullName evidence="1">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_308957</name>
    </gene>
    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DAPPUDRAFT_308957"/>
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        <property type="entry name" value="PLD-like_dom"/>
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            <begin position="150"/>
            <end position="177"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="212" mass="24137" checksum="4EE47D22E6A249D4" modified="2011-04-05" version="1">MNSVEISGLIPKLGLVVVGIVLVECTRQGLNYLQRKNSKPVIRQVIFFPDKQIACKDFFDSVEGCSRIRCDFSHTTTGFRQLLSHIKSARKSIDIAVYCISCFEIADVVLQRHKVGVRVRVITDQSMEIAFGSQNHRFMKDGIRVHTNKPPFLMHHKFFIIDDELLCSGSFNWTSQAVTGNNESVIITNDPWTVEPFCAEFKKLWQETKPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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        </lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX85488">
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        <property type="gene ID" value="DAPPUDRAFT_237971"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000000305">
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="321" mass="36278" checksum="903D35D89751CF02" modified="2011-04-05" version="1">MYPSVNIDPSLLKGPAFYKLMERHIISLRQQEANGYPRPHPIHKTRAVINSVEIDQLRPKPAIQLKSDERICDRCSTIFKVNSRGYAINHSADDECSYHWGRSFRNPGTNMTSPFSCCGSVRKEKGCATSKHHVFNIENLKTVDGFVHTTERPPLAGGDYGVYAMDCEMCYTTEGGELTRITIVSSDLKIVYDTLVKPDNPVVDYNTRFSGISERDLKHVMTKLKDVQAFLLNLLSSKTILIGHGLGSDLRALRLIHDTVIDTSIVFPHSRGPPYKRGLKKLILDHFQKHIQKDGGHNSVEDAIACMELMLWKIKPLLYKI</sequence>
</entry>
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    <accession>E9G5A9</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
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    <organism evidence="3">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85664.1"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX85664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="140" mass="15618" checksum="4503114C27C55652" modified="2011-04-05" version="1">MWCDYCHWYSPIRSNSTALVTYCLTGGIIGLVVMISVTIPLLIAASKNSRPGLLLPWLIFNFVTVSLGIGLGLFASIYFMKKKWIQVEGGSVSLAVTLLGSGLHIYFWLVIYSYYKQLKEQLPPTTGQNKYSQLDSSDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9G642</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_46638</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cladocera</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX84870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84870"/>
    <dbReference type="EnsemblMetazoa" id="EFX84870">
        <property type="protein sequence ID" value="EFX84870"/>
        <property type="gene ID" value="DAPPUDRAFT_46638"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_46638"/>
    <dbReference type="eggNOG" id="ENOG502RIXY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041205_0_0_1"/>
    <dbReference type="InParanoid" id="E9G642"/>
    <dbReference type="OMA" id="MRWNSNG"/>
    <dbReference type="OrthoDB" id="1088700at2759"/>
    <dbReference type="PhylomeDB" id="E9G642"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="325" mass="36695" checksum="97BF40D0BAC92EA6" modified="2011-04-05" version="1">MTAETSLSLPDSRSISQHSRGGSGSGRRGVDGRDVSNRICSNNEPTFDELIDPKDLNLNEIARDCFIIPVHLVNRFLPLGLPQTGRASMSVVEVDDPQLIILLHFMTPFMAIQPIFESPLARPASLQGSMASQLLIDLLRDRPGAHGMLLVSIEQDVDYPYINYGVANRQQTNGEEWQQTARLASLERFEPQNLRYFSDHLVDVYEEAATIARPPLQPACRRPLSNKTGYIVCVYKVFDGDDGEKFERNWLYWTGARILYQCVPRCVGLRRITLHKSVSAGDKLYTLMCECSSFMDHLQEAAYIAPALRARLCGYWSIYRVADVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6D1</accession>
    <name>E9G6D1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="7 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DAPPUDRAFT_300808</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Endoplasmic reticulum membrane</location>
            <topology evidence="4 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="7 15"/>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX85012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85012"/>
    <dbReference type="EnsemblMetazoa" id="EFX85012">
        <property type="protein sequence ID" value="EFX85012"/>
        <property type="gene ID" value="DAPPUDRAFT_300808"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300808"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_5_1_1"/>
    <dbReference type="InParanoid" id="E9G6D1"/>
    <dbReference type="OMA" id="DANDVWR"/>
    <dbReference type="OrthoDB" id="203029at2759"/>
    <dbReference type="PhylomeDB" id="E9G6D1"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked mannosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="SSF82109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="9 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012135627" description="Dolichyl-phosphate-mannose--protein mannosyltransferase" evidence="16">
        <location>
            <begin position="16"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="279"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="348"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="409"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFX85012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="691" mass="78721" checksum="EC46A5C08975F870" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6J7</accession>
    <name>E9G6J7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_46346</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="4">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:43816"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:43817"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:43818"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion outer membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX84979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84979"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_46346"/>
    <dbReference type="eggNOG" id="KOG2847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2765076_0_0_1"/>
    <dbReference type="InParanoid" id="E9G6J7"/>
    <dbReference type="OMA" id="LTAHNIG"/>
    <dbReference type="OrthoDB" id="589285at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="PTHR12497"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="7">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX84979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="70" mass="7871" checksum="4825CFB5D30D7606" modified="2011-04-05" version="1" fragment="single">TDVMNSTRVVNRHILVDTLDSRPCHVPVITVANHTSCFDDPGLWSILPIRHVFNVDIIRWSLTAHNIGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9G782</accession>
    <name>E9G782_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_194402</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84690"/>
    <dbReference type="EnsemblMetazoa" id="EFX84690">
        <property type="protein sequence ID" value="EFX84690"/>
        <property type="gene ID" value="DAPPUDRAFT_194402"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_194402"/>
    <dbReference type="eggNOG" id="KOG4578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023483_0_0_1"/>
    <dbReference type="InParanoid" id="E9G782"/>
    <dbReference type="OMA" id="WCVRVDT"/>
    <dbReference type="OrthoDB" id="1057719at2759"/>
    <dbReference type="PhylomeDB" id="E9G782"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="SSF57610"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Kazal-like" evidence="8">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="58"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="215"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="118"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="252"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX84690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="432" mass="47666" checksum="BAD10C2B87CD0B34" modified="2011-04-05" version="1">MVSAECQTLTQQCGEELGLFSSGSNQSAGRSASTTSTTTTSTPAALEPVCGSDGRTYSSRCELQRARCEGHPVRVRNRGSCHAGGVGSAGGLGKKSAPTGETFIPECNEDGRFAEIQCHQGTGYCWCVTPDGKPIPGSSIRHNKPNCKLPLLARRPTIERTTGRYKPPGAKLLATHESLLFYEGQMITRFLLWTKHSSILSPEVSSVEEIEPVEANDCYSDREAAQEEVDHGAKGMYVPECTPDNKYQRVQCHKSAGYCWCANDETGKPIPGTSVQNSKPTNCDNLPAHVLNRPTPPPVPKENLKPVYPCTGKRKSRLQSDMVEFFKENLAAFLVNKTANNPNSIAGPDYNLPPRERVAKWQLQQLDANKNNVIDRQETRELRLLFKRSQKLRRCSKKLPAFCDTNADKRITADEWLRCLGVVKGIFTKSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9G906</accession>
    <name>E9G906_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pept_C1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_315189</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84066"/>
    <dbReference type="EnsemblMetazoa" id="EFX84066">
        <property type="protein sequence ID" value="EFX84066"/>
        <property type="gene ID" value="DAPPUDRAFT_315189"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315189"/>
    <dbReference type="eggNOG" id="KOG1542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012184_1_2_1"/>
    <dbReference type="InParanoid" id="E9G906"/>
    <dbReference type="OrthoDB" id="1264766at2759"/>
    <dbReference type="PhylomeDB" id="E9G906"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018748294" description="Pept_C1 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="3">
        <location>
            <begin position="127"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX84066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="347" mass="38097" checksum="EB8AAC2B6C36A97B" modified="2011-04-05" version="1">MSVWRMSKFTFLVALLVVVCGVVQTRADVEDAWQQYLKEYPLGIKTKAEYGKSKSNFERIHSLIEEHNADPKSTYQMGHNEFSILDVKERKKYLLNNTLAYSTKSLYEELGFETGLTAEEDDDLRNLPSSVDYRNHRCMQPVKNQGGCGSCSAFAATAVVEFAQCMKSGTPVNLSEQQIVDCDFADRRCGGGSYHEYWKSLIRAGGQAYSAGYPYVSGATKVRGPTCNKNKSKGAQLAATNPIVALQKGDVNGVMTLLARGKVVAVCVGVTDKFMNYRSGVYTTPCKGREGLHAIAAVGYGTSNGGTKYWIIRNSWGPKFGDAGYILFQRGINLCGVERDLATVNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9GB73</accession>
    <name>E9GB73_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_48162</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83413"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_48162"/>
    <dbReference type="eggNOG" id="KOG2990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050402_1_1_1"/>
    <dbReference type="InParanoid" id="E9GB73"/>
    <dbReference type="OMA" id="DMEANEQ"/>
    <dbReference type="OrthoDB" id="1583452at2759"/>
    <dbReference type="PhylomeDB" id="E9GB73"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="PTHR12111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="233" mass="27127" checksum="DC01485E6B2DDBDE" modified="2011-04-05" version="1" fragment="single">NKYYPPDWRPEMGSINKYHGTHALRERANKLHLGILIIRFEMPYNIWCEGCPDKSIPIGMGVRYNAEKTKVGMYYSTPIYQFRFKCHLCPNYIVMKTDPGNLDYVIVSGAKRQERRWDPLDNEQVVPEEKSTSQKLATDAMFKLEHGEKDALKSKNAAPIIDRLQDHRERWRDDYTTNRILRDQFRKELKARAAVDAALLAKSSLDIKLLPQSEDDQKIASLLRLNPTQSKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBC9</accession>
    <name>E9GBC9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_48516</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
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            <text>H(+)(out) + L-cystine(out) = H(+)(in) + L-cystine(in)</text>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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        </source>
    </evidence>
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        <source>
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        </source>
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                <person name="Thomas W.K."/>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX82520.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="572" mass="65708" checksum="7F88DE681B2C4AF8" modified="2011-04-05" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732539">
        <property type="protein sequence ID" value="EFX82715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82715">
        <property type="protein sequence ID" value="EFX82715"/>
        <property type="gene ID" value="DAPPUDRAFT_101431"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_101431"/>
    <dbReference type="HOGENOM" id="CLU_1950929_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX82715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="129" mass="13722" checksum="3191B61280031B93" modified="2011-04-05" version="1">MPQSTIHQVAIPFILLRHSKGAAAHRIACGLCTTFGRPSPGNSTSRDQIPVAWAVDDGSSWTNGQTADQDPEAAGCPPFCSCAPHGRIVVDVVIGAAPHPGRFTASSADFFTAAVTRRGGRQQHRHLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDL5</accession>
    <name>E9GDL5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_241176</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82459">
        <property type="protein sequence ID" value="EFX82459"/>
        <property type="gene ID" value="DAPPUDRAFT_241176"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241176"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049234_0_0_1"/>
    <dbReference type="InParanoid" id="E9GDL5"/>
    <dbReference type="OMA" id="GKHYGTE"/>
    <dbReference type="OrthoDB" id="1583175at2759"/>
    <dbReference type="PhylomeDB" id="E9GDL5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013175284" evidence="2">
        <location>
            <begin position="16"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX82459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="311" mass="35880" checksum="E5642444329A6CAB" modified="2011-04-05" version="1">MKFFIIVALFAVAAANSYEAPKYEAPKYEAPKYVDPKYEAPKYEAPKYETPKYEAPKYEAPKYVDPKYEAPKYETPKYVAPKYEAPKYETPKYEAPKYEAPKYETPKYVAPKYEAPKYETPKYEAPKYETPKYEAPKYVAPKYEAPKYETPKYVAPKYEAPKYETPKYEAPKYEAPKYETPKYEAPKYEEVTYAAQPYSFGYDVQDKESYTDFEHNEKSDYNVVTGSYRVVLPDSRVQIVTYKADANGYTADVKYEGEAKYPEYVESQYKAAASYAAPAYKAPEYKKPAYTAPAYTAPAYTAPAYQAPAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDZ1</accession>
    <name>E9GDZ1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_101617</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82173">
        <property type="protein sequence ID" value="EFX82173"/>
        <property type="gene ID" value="DAPPUDRAFT_101617"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_101617"/>
    <dbReference type="eggNOG" id="ENOG502QSK2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_804775_0_0_1"/>
    <dbReference type="InParanoid" id="E9GDZ1"/>
    <dbReference type="OrthoDB" id="1910936at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="206"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="345" mass="37588" checksum="D459608607776367" modified="2011-04-05" version="1">MTDDKEIKWHLAADDFLSITHADDRVTKRKIIANDDKADKTAVQTALDDKADKTAVQTALDDKADKTALDLKADITALDLKADKTALETINTALNTITTPSSLGTIPTSCGDLKTIGFVKSGIFSIMDNKQVKNVYCDFTKTTNAAITTPSSLGTIPTSCGDLKTIGFVKSGIFSIMDNKQVKNVYCDFTKTTNAELQKMIGTVDVKSTAVYFFAQMTRIYSTALTTISFDSIKLNVGTALNTATGIFVAPTTGKYYFAFSGISDSGVKARVLMQTAKTGTTDWILVGEGYGDTTFKTFSIHATLELVKGDQVRLYLLEGRIHEAVSHNYFNYVGWLVEENELTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GE48</accession>
    <name>E9GE48_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_302556</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82375">
        <property type="protein sequence ID" value="EFX82375"/>
        <property type="gene ID" value="DAPPUDRAFT_302556"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302556"/>
    <dbReference type="HOGENOM" id="CLU_1327563_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236931" evidence="2">
        <location>
            <begin position="28"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX82375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="207" mass="24568" checksum="0B43219C6A7EB98C" modified="2011-04-05" version="1">MAGVPIKFKFSLFTLAVLFGLLALSSSSEFYDEELEERDDRFAESEEDSRQYGRRPVQQVHHNHYGQYHYPQPVRPVAPQLPVCGNHPQCKSCKAPTVPNYQPKSPSARSTRQTSFVEEESQIEEFRSEEDYETRYYQQPVKQYHYQTTQPPRRQCNAVCKPPVPVTTQKPYVQQTQAYQHYQQPQYPQYQQPQYQQPQYQYWPYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEC5</accession>
    <name>E9GEC5_DAPPU</name>
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        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_302642</name>
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    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX82237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX82237"/>
        <property type="gene ID" value="DAPPUDRAFT_302642"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302642"/>
    <dbReference type="HOGENOM" id="CLU_033941_0_0_1"/>
    <dbReference type="InParanoid" id="E9GEC5"/>
    <dbReference type="OrthoDB" id="711255at2759"/>
    <dbReference type="PhylomeDB" id="E9GEC5"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="343" mass="39490" checksum="6E5E1D36E246FA5E" modified="2011-04-05" version="1">MSISSSMSLDDDEDIAEFVKCRICLREYNEIDRKPKFLPCSHTLCFECIYNISQGYDIITCPFCRKACEILELPNNVYALEMLKQEKKKKMEKMSTDFLDITERSLKNMFMVHKRIDDQLAKTMSSINLAGEKTQKLVEENNSNLAKMISLMELLKKQSMISPNSVPTKLFFSGNLQSKFIFRLYQSGRLKGEIHICPVPTYYPDFVQKLGEFCYRSPKEFCSSVDKAMAGVFVLFPMLHPEFQPVVPSMTEHMDSWTAAAKDVDEVGITMVKASGNKITDWSLVFILEDDEDFQMHENLPQTVTDNEVFGRVIHHHMLEPLVRLSLTSKSDRANYVMTLESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEE2</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="101" mass="11428" checksum="AE34CCFE56B987C7" modified="2011-04-05" version="1">MTLAPASGAENLKIEMRKSVSFSDSLSPKPLNGQHLRVIWPRWSGNPKGLSGPLKGGVVLDYLSARFNFTYEMVRVTENWLEPKANGRGLFSYLWDRVEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEK4</accession>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX82296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_316989"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_316989"/>
    <dbReference type="eggNOG" id="ENOG502RSHE">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_984361_0_0_1"/>
    <dbReference type="InParanoid" id="E9GEK4"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036706">
        <property type="entry name" value="VOMI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18841">
        <property type="entry name" value="PTHR18841"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03762">
        <property type="entry name" value="VOMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51092">
        <property type="entry name" value="SSF51092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237420" evidence="2">
        <location>
            <begin position="24"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX82296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="283" mass="31494" checksum="1E2BEFB005A2D3E4" modified="2011-04-05" version="1">MARFCSMLSVGILILTVFTCSIGSQTVDERLQQFTTSFMQFKRVVETKVTRLETKNTQLEALIAQKDKQYELLAAKVAELELSLQNEQPPLTSNTRTAVIHTEEVITVTNGEKDGRWGRLESCPTGARAVGYQTQNKFEALFEDVDETGLNMLVIFCDDPLQTKISSPVGFLGDWQPIRECAAGSYMKSFRMRVSPAGQVSDRNTTDNTAINNMRFMCSNGRELRSEGNTGGTWGEYSAECLDGICGMETRFRPDGGLLVDNTALNDVRFTCCTPDDLEILTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEP1</accession>
    <name>E9GEP1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_302840</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL732541">
        <property type="protein sequence ID" value="EFX81871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81871"/>
    <dbReference type="EnsemblMetazoa" id="EFX81871">
        <property type="protein sequence ID" value="EFX81871"/>
        <property type="gene ID" value="DAPPUDRAFT_302840"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302840"/>
    <dbReference type="eggNOG" id="KOG0238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_1_1"/>
    <dbReference type="InParanoid" id="E9GEP1"/>
    <dbReference type="OMA" id="FVEICSH"/>
    <dbReference type="OrthoDB" id="254436at2759"/>
    <dbReference type="PhylomeDB" id="E9GEP1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="39"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="158"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="635"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX81871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="712" mass="78150" checksum="22D60DD394D7E8D7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9GF17</accession>
    <name>E9GF17_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_210964</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TECPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732541">
        <property type="protein sequence ID" value="EFX81979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81979"/>
    <dbReference type="EnsemblMetazoa" id="EFX81979">
        <property type="protein sequence ID" value="EFX81979"/>
        <property type="gene ID" value="DAPPUDRAFT_210964"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_210964"/>
    <dbReference type="eggNOG" id="KOG3669">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057765_0_0_1"/>
    <dbReference type="InParanoid" id="E9GF17"/>
    <dbReference type="OMA" id="HETRTGI"/>
    <dbReference type="OrthoDB" id="119234at2759"/>
    <dbReference type="PhylomeDB" id="E9GF17"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016043">
        <property type="term" value="P:cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006624">
        <property type="entry name" value="Beta-propeller_rpt_TECPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="Peroxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06462">
        <property type="entry name" value="Hyd_WA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00706">
        <property type="entry name" value="TECPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxin/Ferlin" evidence="2">
        <location>
            <begin position="73"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX81979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="400" mass="44833" checksum="96CD06EAFE05CD7F" modified="2011-04-05" version="1">MGDPFVHETRTGIPSHALWTQLGGHFRHVESSSGGVVWALGQDGTCWIHTGFHGGGFFKGVFGGSSHGIHPLSDEGHVNLYENQRWNPVAGFSARGLPTDRPSWSDITGLHAYNKENMSLPNRNWNWVSEWLVDYHPPDGADREGWQYATDYPSRFHTYKGSFDYVRRKRWQRKCRYTSTGPWFQFGLTKLLDISMQVDHSGRPDEPLLLWAIAANGSILRRVGVTVIKPQGESWEAVLGEHAFQSLSIGVDGRVWAITSLGAPALRHRVTLSNPDGVAWLLMDRPEGNPTLRQISAGDIQVWAVDSQDRLYRRKDIVSILPEGTSWELIDEHVLHVSVGKHDQVWAVLDLKNNEPKVKERGSICIRRGITASCPGGTGWEFVIGGGWSFVCNRGHDIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIA9</accession>
    <name>E9GIA9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_51066</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732546">
        <property type="protein sequence ID" value="EFX80802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80802"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_51066"/>
    <dbReference type="eggNOG" id="KOG4463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057710_1_0_1"/>
    <dbReference type="InParanoid" id="E9GIA9"/>
    <dbReference type="OrthoDB" id="975575at2759"/>
    <dbReference type="PhylomeDB" id="E9GIA9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX80802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="229" mass="25643" checksum="6DEEEE285946B583" modified="2011-04-05" version="1" fragment="single">QVWRLFTSQTAFLETKDLICAALLIYYFRVFERRLGSKKFASHLLATSLISLGLQVPIILLIRSTGWASYHHGHLPPGPYGLIFPLFVPYLCDIPRMTRTHILGIPITGKTLTYLVGLQVCSTSFPTAVSAFCSIAAGLWYRWNVLRVQDWLAIPDWLARITDMTFGRLLSSSPPADGPMEVRPNDPTPPSEENVTFLTSMGFSRDRVMRALQTTGNNVEAATNLLLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJG8</accession>
    <name>E9GJG8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_318654</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80500">
        <property type="protein sequence ID" value="EFX80500"/>
        <property type="gene ID" value="DAPPUDRAFT_318654"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_318654"/>
    <dbReference type="HOGENOM" id="CLU_033667_0_0_1"/>
    <dbReference type="InParanoid" id="E9GJG8"/>
    <dbReference type="OrthoDB" id="1027299at2759"/>
    <dbReference type="PhylomeDB" id="E9GJG8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX80500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="509" mass="58311" checksum="C42AD51D98412585" modified="2011-04-05" version="1">MPQPKWYGKSLSALCMENIVDNMEKWTALRSSEHVSCHFFHLPSHCLEYMTECLLKDYSITEDMFDLLLSPHMKVLDLSQLGTRRDANRNLRIFRLASDRCLQLTTLKIHDGYGFVFDLNRNFQVEDAFASILQRFEHLQILDLSSTIYGACCMLKLGSTCKPKIKELLVDCCPGVTDSVVEVFCNGQSSLQKLSVNGTEVTHSGIRFAIEHLPVLKELDCDDESDILKAFRRIRRETRESKKYSLTKWMWNPPDEVSYKKGSVSLMVDMCPSLVDVFLYVNDEGFTDEELLGFRKLKQLKNVEIEVPFLPSIISIRGGVIPLLQARGLTLKGLYLSVEVTSEEVYLIIQCCPNIRRLLLVIKSTVQDTPEPVVDDGIHSSLCSPKEVFPLRKLETISLSSYYSRFAIPRGLLLLLLSSPTLTDISINKCFTLDDQIIEEACARNSFKYLTRLWLYGCSNVNQKGIDFFLNEANPLSYIYLRDCGNVNLEHMKTMAQEKHWNVKWNDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9GN71</accession>
    <name>E9GN71_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_52904</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732554">
        <property type="protein sequence ID" value="EFX78986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78986"/>
    <dbReference type="EnsemblMetazoa" id="EFX78986">
        <property type="protein sequence ID" value="EFX78986"/>
        <property type="gene ID" value="DAPPUDRAFT_52904"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_52904"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_3_0_1"/>
    <dbReference type="InParanoid" id="E9GN71"/>
    <dbReference type="OMA" id="WQDLKEE"/>
    <dbReference type="OrthoDB" id="826687at2759"/>
    <dbReference type="PhylomeDB" id="E9GN71"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
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        <source>
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</entry>
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        </lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
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                <person name="Pritham E.J."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
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            <begin position="25"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX79046.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="84" mass="9436" checksum="62BBF75B9BA1CD24" modified="2011-04-05" version="1">MGSGVLFSFFFLVFFSLMIGPNNAKSAFCRSICCCLLLVFSSTSVGSFHDAVEVKIDFFPSRIFNQTLSDRKIMLVIFTPCIFK</sequence>
</entry>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX78763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="230" mass="25730" checksum="72D4D8D5EC158BC3" modified="2011-04-05" version="1">MTATITPLALNRHSSCFRLTDFIYKTLRNFHLLSRCPTRRVCRGGRTRLRWGNSLYSNLALINARSINRKSELINDFISSSSIDVLAVTESWLSGDDGDKDLRAMCPAGYSFVHRSRGSRGFGIALIFNSMMSAQRLPSPALHSTFESLDVLLVFRRFRLRLVVINSSSSIPAKKFLTMMESYGFHQYVTGPTHDKGHTLDLLFARPDDGLISCASVTSGSVTIMLWSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
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    <name>E9GPG0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CASPASE_P20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Shapiro H."/>
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                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732556">
        <property type="protein sequence ID" value="EFX78634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78634">
        <property type="protein sequence ID" value="EFX78634"/>
        <property type="gene ID" value="DAPPUDRAFT_53228"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_53228"/>
    <dbReference type="HOGENOM" id="CLU_2504200_0_0_1"/>
    <dbReference type="InParanoid" id="E9GPG0"/>
    <dbReference type="PhylomeDB" id="E9GPG0"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASPASE_P20" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX78634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="86" mass="9903" checksum="2B1D6DE1CA6956CD" modified="2011-04-05" version="1" fragment="single">EDLTYDQATKKINRLQVIDWNLFDYLSIGLMSHGDSGKFLTADCREKHIEDFCSEFSGIKFPGLLGEPKIFFLNVCRGERQNKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPS7</accession>
    <name>E9GPS7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_305160</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732557">
        <property type="protein sequence ID" value="EFX78435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78435"/>
    <dbReference type="EnsemblMetazoa" id="EFX78435">
        <property type="protein sequence ID" value="EFX78435"/>
        <property type="gene ID" value="DAPPUDRAFT_305160"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305160"/>
    <dbReference type="eggNOG" id="KOG4321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056812_1_0_1"/>
    <dbReference type="InParanoid" id="E9GPS7"/>
    <dbReference type="OMA" id="SDEMYTI"/>
    <dbReference type="OrthoDB" id="1558547at2759"/>
    <dbReference type="PhylomeDB" id="E9GPS7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="84"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX78435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="302" mass="34609" checksum="84F277AFD5795AD1" modified="2011-04-05" version="1">MFTWASIDIYYSSWLSWLFTPLIVVSLLPGIIIIMLYITSSLLYIYKLHRRRLLDAYDKDIWDAGRKVVSAIWDALGWIWHGYEIHGIENIPAGGALLVYYHGAVPIDFYYICSHILLYEGRLINPVGDRFLFKIPGWGSLLEAFGVIPGTVQSCASLLRKGNLLAIAPGGVYEAQLGDHNYEVLWRQRLGFAKVAIEAKVPIIPIFTRNIREAFRSFNICQSFWHWLYQKTHLPLVPIYGGFPVKLTTFIGRAIPYDESHTPESLVKLVTQNMKEMIANHQPKPGNILRAITERFTLRKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GR30</accession>
    <name>E9GR30_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_320784</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732559">
        <property type="protein sequence ID" value="EFX77938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77938">
        <property type="protein sequence ID" value="EFX77938"/>
        <property type="gene ID" value="DAPPUDRAFT_320784"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_320784"/>
    <dbReference type="HOGENOM" id="CLU_1476605_0_0_1"/>
    <dbReference type="OrthoDB" id="1769503at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="183" mass="20326" checksum="84E1B887BBCF307F" modified="2011-04-05" version="1">MSEADDDGDFDENADPNTSHVSQSNTSSNSNPVNKLAIPAEFFTCVGDVPGKNARVYRCLHPGCVPKKKKDGSDKPLVVYHNSRHNAMRTRHFLNHDPGNQLGHTKLWEDAVKLLDNSTTLNNTATSVNRRVMISQEDLDSWVLIMKKIFVAQKLCSKENLPGFKDKTCLNLPTIQVTGPPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9GR90</accession>
    <name>E9GR90_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_198128</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="GL732559">
        <property type="protein sequence ID" value="EFX78036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78036"/>
    <dbReference type="EnsemblMetazoa" id="EFX78036">
        <property type="protein sequence ID" value="EFX78036"/>
        <property type="gene ID" value="DAPPUDRAFT_198128"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_198128"/>
    <dbReference type="eggNOG" id="ENOG502QRCP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019666_1_1_1"/>
    <dbReference type="InParanoid" id="E9GR90"/>
    <dbReference type="OMA" id="WEVYDEH"/>
    <dbReference type="OrthoDB" id="1021041at2759"/>
    <dbReference type="PhylomeDB" id="E9GR90"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015929">
        <property type="term" value="F:hexosaminidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
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                <person name="Thomas W.K."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to all microtubule populations.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAP Jupiter family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732561">
        <property type="protein sequence ID" value="EFX77762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77762">
        <property type="protein sequence ID" value="EFX77762"/>
        <property type="gene ID" value="DAPPUDRAFT_321103"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_321103"/>
    <dbReference type="HOGENOM" id="CLU_2199584_0_0_1"/>
    <dbReference type="InParanoid" id="E9GRX3"/>
    <dbReference type="OrthoDB" id="1620782at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033335">
        <property type="entry name" value="JUPITER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17054">
        <property type="entry name" value="JUPITER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX77762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="108" mass="11080" checksum="2B40E46BD52BB277" modified="2011-04-05" version="1">MPAYYEFRSVEMDRVGCGKRKVLKPPGGGSSDIFGTADSKPAAGTKSNHSDHFGSGSGFGGDLSDLGVKASSVDSNDGASTPSQTSTSNGSPNNSEPNTPRSESCQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GS01</accession>
    <name>E9GS01_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_225596</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732561">
        <property type="protein sequence ID" value="EFX77746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77746">
        <property type="protein sequence ID" value="EFX77746"/>
        <property type="gene ID" value="DAPPUDRAFT_225596"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_225596"/>
    <dbReference type="HOGENOM" id="CLU_160215_0_0_1"/>
    <dbReference type="OMA" id="TKVMMLM"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240548" evidence="1">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="132" mass="12502" checksum="5CD0C2A05E6C0A90" modified="2011-04-05" version="1">MNTKVMMLMVLASVMIGSSFSAPQFLGRPGGLIGLRRPGGFGGGGFGNQGFGNQGFGNQGFGNQGFVPGFGGGNAAGIGNGAVIGNQAIGTGTGIANPGPGGFGIGLGVGAAVATPIGNFAIGDGQSISVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9GT06</accession>
    <name>E9GT06_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_247860</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732563">
        <property type="protein sequence ID" value="EFX77285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77285">
        <property type="protein sequence ID" value="EFX77285"/>
        <property type="gene ID" value="DAPPUDRAFT_247860"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_247860"/>
    <dbReference type="HOGENOM" id="CLU_050584_0_0_1"/>
    <dbReference type="InParanoid" id="E9GT06"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="PhylomeDB" id="E9GT06"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="235"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX77285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="437" mass="49125" checksum="15D981EC673D17AD" modified="2011-04-05" version="1">MSVGPRLSSRYLPYLTTTTRQENQQAPEIDLLKEQLQAVQAELKNLRDAVIPSMNKEIKTLTVDMAAVNGKLNHIDERFDDVLRRQEENARSQTSSSTNWTVMNSLMDTLSISKKTPAFSPQSPSQTTGTSYKSTDRAMLLRSDDEILRGPLTYTGHPPYFDLNDQDLMDQAAKIVLLSETHWSSGVAPKFKTHHILKKDRPNRMGGGFFPIHLNTPGTVEAIGASILCKDNQHIDFLSIYVPKADCETEDIEDLLNRTNPFRRGDFNGHHLLWEPNSIENKAGKSIHKALINDPNVTITPITTPNLGTRIDLASGKASTIDLTITSPTIAVSATVTPEPYMGSDHLPLIITLNARATRLINRPAAWKLNKDNWTQWNLNIEENLRQRNFTNITDPEDAIASFSECIETSNTRYLKKTNLNVNANVTKNPTRPWWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTI4</accession>
    <name>E9GTI4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mannanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_20677</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <reaction evidence="1">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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                <person name="Zdobnov E.M."/>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Basu M.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="147"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
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        </recommendedName>
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    <organism evidence="7">
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732566">
        <property type="protein sequence ID" value="EFX76870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76870"/>
    <dbReference type="EnsemblMetazoa" id="EFX76870">
        <property type="protein sequence ID" value="EFX76870"/>
        <property type="gene ID" value="DAPPUDRAFT_198783"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_198783"/>
    <dbReference type="eggNOG" id="KOG1505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041844_5_2_1"/>
    <dbReference type="InParanoid" id="E9GUC8"/>
    <dbReference type="OMA" id="IAQWCIN"/>
    <dbReference type="OrthoDB" id="959325at2759"/>
    <dbReference type="PhylomeDB" id="E9GUC8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="5">
        <location>
            <begin position="90"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX76870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="391" mass="44805" checksum="64897D542916C630" modified="2011-04-05" version="1">MLAQIKTAGTCIIFLALFVCFIVSGLLINGVQLCLWLTVRPLSRWLYRKINYYLLACLWNQVLLIIDWSGSAFSVYTDTETWTKLGKENALIILNHSNELDWLVAWVLGSQANVLGNSKLFIKKAVEWIPIIGWAWKFAEIGFLERNWEKDKSTMDLFVKNLIEYPDPVWLLFFPEGTRFTKDKHNVSMEFAAKKGLPHLNNLLIPRTRGFFAITQQLKQNFDAVYSCTLCFNTKLGAFPSLLNVFLGRPVFGEVFLERVPFQDIPSEINQSAEWLLNNFEKRDKLMDAYEKNGVFPTSLAEEDSKYFKGPIRCHYRPRSALPFLLFCLWTSFCLPLMFNSVKCLLGTGFSSLLAIVFIIGITASFIYKLIDITLISRGSSYGIEAPKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9GUJ8</accession>
    <name>E9GUJ8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_54851</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732566">
        <property type="protein sequence ID" value="EFX76734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76734">
        <property type="protein sequence ID" value="EFX76734"/>
        <property type="gene ID" value="DAPPUDRAFT_54851"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_54851"/>
    <dbReference type="eggNOG" id="ENOG502QVSM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035551_0_0_1"/>
    <dbReference type="InParanoid" id="E9GUJ8"/>
    <dbReference type="OMA" id="KRILVLW"/>
    <dbReference type="OrthoDB" id="868229at2759"/>
    <dbReference type="PhylomeDB" id="E9GUJ8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028054">
        <property type="entry name" value="DUF4481"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31193">
        <property type="entry name" value="PTHR31193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14800">
        <property type="entry name" value="DUF4481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="419" mass="47611" checksum="E0B088DE98905E76" modified="2011-04-05" version="1">MGNEEQSSNSLADKKWVQFDENNDVKRHVEPIPPTPTVSNYNGAVIDTETVQIDIDKLKHLAQSKVPDAEGQVEELQKPVNPTMRNVSLDDLDGADNLATVVDPSISRGFSNGDVIVTVLPVNQKWPWITPAEFRPELVPEELMAEGLSLTVEDYVQIMENLVHDVRFTAYNLCYKRLLMAWLLASFIVLLGLLFSGAKGITLFGCGVIWLIINAGAIFVCMWMKNKMNHGLEKAVAKANQTLTRHRIILGVDDRGKLSCHKTHLCFIYFDTTDCVRKLQSLLDAEEHTNRSETNAEDLQRQRQMRQRMDIDDTDIVVAGANPIRISRKQESAERLLLRYAQRWAKEFLRHRLDWSVDDSYNTYNSANPSFGIAPHANYPRPRHHSSALCLCQFIEDYLRNKPRKDPRSCCSCSCAPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GV15</accession>
    <name>E9GV15_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_248698</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732567">
        <property type="protein sequence ID" value="EFX76693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76693">
        <property type="protein sequence ID" value="EFX76693"/>
        <property type="gene ID" value="DAPPUDRAFT_248698"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_248698"/>
    <dbReference type="HOGENOM" id="CLU_2592209_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="80" mass="9382" checksum="38D859784701FCCC" modified="2011-04-05" version="1">MDDCPPLQKKLHTDEIQVRHHHMAPTRKQESSNVPAQTPLRAQPTQCVQQHNRPGSRPKLPLWMRSHRKHPPHTRILPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9GV39</accession>
    <name>E9GV39_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_322150</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732567">
        <property type="protein sequence ID" value="EFX76597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76597"/>
    <dbReference type="EnsemblMetazoa" id="EFX76597">
        <property type="protein sequence ID" value="EFX76597"/>
        <property type="gene ID" value="DAPPUDRAFT_322150"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_322150"/>
    <dbReference type="eggNOG" id="KOG4566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2173532_0_0_1"/>
    <dbReference type="InParanoid" id="E9GV39"/>
    <dbReference type="OrthoDB" id="1932070at2759"/>
    <dbReference type="PhylomeDB" id="E9GV39"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX76597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="110" mass="13441" checksum="2592F570E22633A8" modified="2011-04-05" version="1">MPQFEYTIPTLIDLIGQRSWLIFHLLRCISREIEWMQFESSHWEKFEDYRFLRDIINGLEVVNDSAERGVKLITDFRNVVHDEEQQQFLVQFVENHRQQVSFNRRKQQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9GWU7</accession>
    <name>E9GWU7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="4">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2B</fullName>
            <shortName evidence="4">MOCS2B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_199098</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12160"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MoaE family. MOCS2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="4"/>
    <dbReference type="EMBL" id="GL732571">
        <property type="protein sequence ID" value="EFX75969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75969"/>
    <dbReference type="EnsemblMetazoa" id="EFX75969">
        <property type="protein sequence ID" value="EFX75969"/>
        <property type="gene ID" value="DAPPUDRAFT_199098"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_199098"/>
    <dbReference type="eggNOG" id="KOG3307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045449_0_0_1"/>
    <dbReference type="InParanoid" id="E9GWU7"/>
    <dbReference type="OMA" id="GIAIYHR"/>
    <dbReference type="OrthoDB" id="1543738at2759"/>
    <dbReference type="PhylomeDB" id="E9GWU7"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03052">
        <property type="entry name" value="MOC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028888">
        <property type="entry name" value="MOCS2B_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX75969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="365" mass="41765" checksum="D5862405CA687BD9" modified="2011-04-05" version="1">MDIINLVEEQLDVNSIYSKVVEHSTGAVSLFVGTTRNNFEGKKVISLEYEAFKPMACKEIKKICENIREKWKVKHIAFHHRLGEVPVGEASVVIAVSSEHRAESLEAVQFGIDALKKSVPIWKKELYSDGAPEWKANKECLWTILSSSQRFPIFALSLYNNIYCVILKMNQEEDASLSKKRKIMVDYAAADCVQIKASNLELGKRITAFMERKRSESDVFNVQEFCHRLPLNELENSCARTEAVLVSRKDSKSHLKVSRCVNMWGPQTHSEVPAPSSVNTKLNPTPAIQERLQNMEKHLGFNSREQPIPLDVYGRLKALEDRILHLESISPEYFDGPFNLQNNKEDEDMISKIEQKMDELRRKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9GXT4</accession>
    <name>E9GXT4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_306676</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732573">
        <property type="protein sequence ID" value="EFX75760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75760"/>
    <dbReference type="EnsemblMetazoa" id="EFX75760">
        <property type="protein sequence ID" value="EFX75760"/>
        <property type="gene ID" value="DAPPUDRAFT_306676"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306676"/>
    <dbReference type="eggNOG" id="KOG3053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046472_1_1_1"/>
    <dbReference type="InParanoid" id="E9GXT4"/>
    <dbReference type="OMA" id="KRYCWVC"/>
    <dbReference type="OrthoDB" id="1210654at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0000318"/>
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    </feature>
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            <begin position="17"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="305" mass="34469" checksum="921B218F157290C7" modified="2011-04-05" version="1">MEETEEPVIETNRREDLHDDNKRYCWVCFATDEDDLTAVWVQPCQCSGTTRWVHESCLQRWVDEKQKGNSLERVHCPQCNTQYVIVFPPIGKLILVLDIADRIIYRVCPFIAAGVVIGSIYWTAVTYGALTIMQAVGAKEGLALMEQSDPLFLLIGLPTVPIMLILGRLVRWEEALLGFLNKNVPRVPIVKHLLPTFQIASDSVRPHTQGTEPPFSDPVSATRVLCGALIFPSMAVLFGKLLFHPVHSNLKKTFFGGIAFLMLKGALKIYYKQQILIRQYQRRVLDFAKRPSDGKEIKTSSNTNP</sequence>
</entry>
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    <accession>E9GZX8</accession>
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        <submittedName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX74895.1"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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            <fullName evidence="1">Peptidase S1 domain-containing protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
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        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
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        <property type="entry name" value="Trypsin"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRYPSIN_DOM"/>
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    </dbReference>
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            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="80" mass="8238" checksum="FEA8E53D319930ED" modified="2011-04-05" version="1" fragment="single">ISNAECSAFYGGGIITANTICSSGAGGKGICPSDNGGPMSYMTTDGNFVQIGVASFFSSTGCENGHPSGFTRIRNYLDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-06-17" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9H1J1</accession>
    <name>E9H1J1_DAPPU</name>
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        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX74496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74496">
        <property type="protein sequence ID" value="EFX74496"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
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    <sequence length="167" mass="19872" checksum="6E52DC241495A39F" modified="2011-04-05" version="1">MMKMLLSYGMFGIKWIGQNKPNIKFKLVLRYLLDKNLPENITVTYDSQSLENIRTVWLSWWLFVGLSTLEAQSARKSLLEKIDEERLNCIVEGWRELHCKDIKPQRIYSKSLIPEAVDNFAFHLDSKFKHLGDETRKKVHEEAMQFFSKVNFYQQYLIFCCIISILR</sequence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Arnold G.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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        </location>
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    <feature type="chain" id="PRO_5003241522" evidence="1">
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    <feature type="domain" description="FAS1" evidence="2">
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    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="194"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX73084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="348" mass="38481" checksum="273146A38E57B063" modified="2011-04-05" version="1">MCFFAIVAAYAIISSLADAYTPTNKYTEFIEWNRNSSQTADIPIPTGNILTVLTENGFTTFVDLIIKSGLEETFSQPGPFVVWAPTNEAFSAIDRETFNSILIDSSLLKDILTYHLTLFGQPYTLISAIKDELARPTVQGQVVRINVYRKKGSSFASKRSVTVNGALVVNTFSAGESIIYVINRVLNPQDLDSRNTKINYLRRHPEFSIFLKISDTLGFSEDSFKSPMKTVFVPTNAAFQALPVSELEALFDNKQALLILFNTYTASGTFYSQGLVSGPLPVFSGDNIDINITPGGISIENANIIKADITTVDGVIHIIDAVISHRVEDSTISSDIENHFFIKQHTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6P3</accession>
    <name>E9H6P3_DAPPU</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_31031</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732598">
        <property type="protein sequence ID" value="EFX72543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72543"/>
    <dbReference type="EnsemblMetazoa" id="EFX72543">
        <property type="protein sequence ID" value="EFX72543"/>
        <property type="gene ID" value="DAPPUDRAFT_31031"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_31031"/>
    <dbReference type="eggNOG" id="KOG3211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053568_2_0_1"/>
    <dbReference type="InParanoid" id="E9H6P3"/>
    <dbReference type="OMA" id="VIMMFAG"/>
    <dbReference type="OrthoDB" id="1059579at2759"/>
    <dbReference type="PhylomeDB" id="E9H6P3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="PTHR12226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX72543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="242" mass="26106" checksum="BC3AB9D3BB5F0947" modified="2011-04-05" version="1" fragment="single">LSTDKMEYLKPVILQVLTPQCYDEFFVNFNFFHVECLKAALSKGLGLGIIAGSVLVKVPQILKLFNAKSGEGINLTAIFMELFAISANMAYSYRNEFPFSSWGEGFFLAVQTALVAALVLLYGSGPGKAALSFLACFSAGLALMLSPLAPMQLLWLFQASIVPIIVVSKMIQAVANYRQGGTGQLSAVTIFLLTGGAAARIFTSIQETGDSMMILTYVVSTFVNCVIAAQVIYYWNSGKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9H7D7</accession>
    <name>E9H7D7_DAPPU</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX72357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72357">
        <property type="protein sequence ID" value="EFX72357"/>
        <property type="gene ID" value="DAPPUDRAFT_254585"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_254585"/>
    <dbReference type="HOGENOM" id="CLU_2006194_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX72357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="124" mass="14010" checksum="6B2DE6B67F378C1A" modified="2011-04-05" version="1">MILNLSCGPLGFGEKKCCDIFSLSPCRILYISTPTHPKELKLRQGDGEREKLWADSSSITTANITNTYGHTSYPYSRHTPRTSNTFAWVYTYTDPHSDQTKASNLVGLFPAVNCFIGYYFRLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9H8E6</accession>
    <name>E9H8E6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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                <person name="Lucas S.M."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_255017"/>
    <dbReference type="HOGENOM" id="CLU_124620_0_0_1"/>
    <dbReference type="OrthoDB" id="744905at33208"/>
    <dbReference type="PhylomeDB" id="E9H8E6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX71997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="187" mass="21135" checksum="8F42A747AAD64189" modified="2011-04-05" version="1">MPYNKNRGRGRNVTQPDEVVTVSNQEGASEITPSNERSGVQDIIYTVALKLDIIEASILQFNKKKKEANQESELKTRKKDKEDAWDSKRDAVFQNYNSSRSYSANFCSKCDMTANWYYTIREVCENGQNLKFLRQNEFIIEDGYITVEVFLPLLPSCPECKSPHSCTTKPGSRDVAVVTANGLSECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9N3</accession>
    <name>E9H9N3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">EOG090X03O4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">EOG090X03O4</name>
        <name evidence="13" type="ORF">DAPPUDRAFT_308832</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CH-H</strain>
            <strain evidence="15">TCO</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732609">
        <property type="protein sequence ID" value="EFX71507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR013955">
        <property type="protein sequence ID" value="SVE83574.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015160">
        <property type="protein sequence ID" value="SVE84779.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71507"/>
    <dbReference type="EnsemblMetazoa" id="EFX71507">
        <property type="protein sequence ID" value="EFX71507"/>
        <property type="gene ID" value="DAPPUDRAFT_308832"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_308832"/>
    <dbReference type="eggNOG" id="KOG1373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031763_2_0_1"/>
    <dbReference type="OMA" id="MFNGAQK"/>
    <dbReference type="OrthoDB" id="482911at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Plug_translocon" evidence="12">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX71507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SVE83574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="SVE84779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="476" mass="52200" checksum="ACB6B492F22CAFDC" modified="2011-04-05" version="1">MGFKFLEVIKPFCSILPEIAKPERKIQFREKVLWTAITLLIFLVCCQIPLFGIMSSDSADPFYWIRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMVITIGQSIVYVMTGMYGEPSEIGRGVCLLIVIQLFIAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGTEFEGAVIALFHLLATRQDKVRALREAFYRQNLPNLMNLLATVLVFAVVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSNLYVISQMLAVKFAGNFLVNLLGVWGDVGGGGPARAYPIGGLCYYLSPPESLGHIAEDPIHAVLYICFMLGSCAFFSKTWIDVSGSSAKDVAKQLKEQQMVMRGHRETSMIHELNRYIPTAAAFGGLCIGALSVIADFMGAIGSGTGILLAVTIIYQYFEIFVKEQSEMGGMSTLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E9HAW6</accession>
    <name>E9HAW6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sodium/potassium-transporting ATPase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_60674</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL732613">
        <property type="protein sequence ID" value="EFX71103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71103"/>
    <dbReference type="EnsemblMetazoa" id="EFX71103">
        <property type="protein sequence ID" value="EFX71103"/>
        <property type="gene ID" value="DAPPUDRAFT_60674"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_60674"/>
    <dbReference type="eggNOG" id="KOG0203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_4_1_1"/>
    <dbReference type="InParanoid" id="E9HAW6"/>
    <dbReference type="OMA" id="KRMNDDY"/>
    <dbReference type="OrthoDB" id="388324at2759"/>
    <dbReference type="PhylomeDB" id="E9HAW6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:cellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:cellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02608">
        <property type="entry name" value="P-type_ATPase_Na-K_like"/>
        <property type="match status" value="1"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Schaack S."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
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                <person name="Andrews J."/>
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                <person name="Tsuchiya D."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX69957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="99" mass="11053" checksum="D9BEFE2008E7BCE2" modified="2011-04-05" version="1">MLVQPSKASKNPTPTKAMLVQQSKASKTPTPTKAMLVQPSKASKNPTKAKLFQQSIKPQRLQHLPRPCSSSNVKPQRLRPVKSSDLHPYPMNMERHMIG</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX69798.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1220768_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
            <dbReference type="EMBL" id="EFX69798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="227" mass="25890" checksum="744A3C194883E55A" modified="2011-04-05" version="1">MDNYLLRRAKTKSRLKEVQTKDEALTKIQLKIMDIAPPLIELAARMRSFSDGQTEEPSPMEARIKRTVEASLQQWGRAYANITKLRREAYVKKVEPHLEFLLEEKSAFAEGKEARELLFTTFSCHVSLRKRKMTSHLMRLTELLRPRIPLHSEEAGENQISVRPATVRLLANLLRADAARASAILVSKERKMDFRGQKIISATTEGMCRGCHSLIPLLCPSSLHLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="8">Uncharacterized protein</fullName>
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    <gene>
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        <name type="scientific">Daphnia pulex</name>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69516"/>
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        <property type="protein sequence ID" value="EFX69516"/>
        <property type="gene ID" value="DAPPUDRAFT_113577"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG1052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004970">
        <property type="term" value="F:ionotropic glutamate receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241097" evidence="5">
        <location>
            <begin position="27"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
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        <location>
            <begin position="52"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="6">
        <location>
            <begin position="162"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX69516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="411" mass="46146" checksum="F019615CA7FEF3A0" modified="2011-04-05" version="1">MTAPKVVAVITSFLLVLASFLHTCYGSKSNSLAGKNLRVVAGHFPPVIYISMNSSGHVVEHSGLLSNQLLYLSAKLNFTFDIFASRENTNGVKQKNGTWNGVIGHILRGEADLGLVPVAINLERYQAIEFSGSLGGDDSGILVKYPEPSVSFTGAFDIWIGWITSGLVIVVISISLAYVTKRQSFGVGEHDAIRAGTFAWYLFGTMVSQGDYCRFRRSSQKLLAATWCLIAFVFVNVYNSTLTSYMSVTYQRPIINSMSDLAANPSYKMACVAGAIQYIDLTPTSTCISFLQKYNSERVKCRLAMAYQKQVQSWKPMFLAVPKSSPYTEEINRESLWFIDIGMRVYWYGKHDKLPDQCRLDYNSKGVASKRSSNRIKLEQFYLPFLVLFCGYLLAFVQFCRENLMRVIRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGC0</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="EFX69198.1"/>
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    <dbReference type="PhylomeDB" id="E9HGC0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="213" mass="25006" checksum="67ABD7FADDD96080" modified="2011-04-05" version="1">MFRPELTLDQKISRASAAKNMIKNGDKYTIGVAYGDSQRFRFEDNGTISLYHQSEKANIPNTVLAWSCMSTINSTISRVDGRLNSAKYSNLLENHVLPLREQTSSNMIQYVHDWFPVHHSAAMKKFYSENRNDLILLDWPWCFGDIMPVEWLWKVMINELNEKQIKVFSEQRLWEEIFKVWQKVCTKDFVFSLLNNITVNLERVVKNQGDYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGF7</accession>
    <name>E9HGF7_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX69177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69177">
        <property type="protein sequence ID" value="EFX69177"/>
        <property type="gene ID" value="DAPPUDRAFT_329389"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_329389"/>
    <dbReference type="HOGENOM" id="CLU_1742396_0_0_1"/>
    <dbReference type="OrthoDB" id="1548094at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX69177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="150" mass="16952" checksum="7C2620DAFC3B70B8" modified="2011-04-05" version="1">MANPLNPNFSLDIVKHVICLNGTNFTPYKHNMNMIFRLKGLNGFVEGRVPKPEPVLLQYQELVQDAGAGVVPPPVPVITNAVAINDWEVSRATFQDILTEFGEAVEMGHRGEHNEVPFQLKMLVTVWWLGNQKETFRQIADRFSTTRGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9HHF5</accession>
    <name>E9HHF5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_259570</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EFX68856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68856"/>
    <dbReference type="EnsemblMetazoa" id="EFX68856">
        <property type="protein sequence ID" value="EFX68856"/>
        <property type="gene ID" value="DAPPUDRAFT_259570"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_259570"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9HHF5"/>
    <dbReference type="OMA" id="CPANILD"/>
    <dbReference type="OrthoDB" id="1343623at2759"/>
    <dbReference type="PhylomeDB" id="E9HHF5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="63"/>
            <end position="139"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="539" mass="60972" checksum="8A97B807F5955691" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HI36</accession>
    <name>E9HI36_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Diplostraca</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX68608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68608">
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        <property type="gene ID" value="DAPPUDRAFT_114423"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_114423"/>
    <dbReference type="HOGENOM" id="CLU_1099440_0_0_1"/>
    <dbReference type="OrthoDB" id="1464029at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX68608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="253" mass="28890" checksum="E83F2DFDC4D76DB4" modified="2011-04-05" version="1">MFAHFVDLPLLLGGSHRVGGGLFGRQGRPFRVAGSLLEADREIEPRRKILQIQLDCLDDLNRLNRQQFDNNSDELWAIKAGAILKAFETQVVKVTKVEGYDGKEVDEAERQCWSVRGGQRIATLFHHRHHHHHRTKRTIVTNPTFRQKVLEKKEKLSSHSLSCSVEFARVDPRRFSDLFGFLGDTKCILFSTLNQSISQKVGDLIIRLMARQTDRRDDVIVTRLTRLKVVSDILIENREGVDETGQVVVATDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJJ4</accession>
    <name>E9HJJ4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_260614</name>
        <name evidence="3" type="ORF">DAPPUDRAFT_260617</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732662">
        <property type="protein sequence ID" value="EFX68102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732662">
        <property type="protein sequence ID" value="EFX68105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68102">
        <property type="protein sequence ID" value="EFX68102"/>
        <property type="gene ID" value="DAPPUDRAFT_260614"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68105">
        <property type="protein sequence ID" value="EFX68105"/>
        <property type="gene ID" value="DAPPUDRAFT_260617"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_260614"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_260617"/>
    <dbReference type="HOGENOM" id="CLU_060622_0_0_1"/>
    <dbReference type="OrthoDB" id="1806536at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="WW_dom-bd_prot_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13361">
        <property type="entry name" value="PTHR13361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX68105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="356" mass="39831" checksum="B6A0F2FC08F263BE" modified="2011-04-05" version="1">MAESVVPALTSIAEEEEVVFDDTITDPARLKRFRTTAKMIHTNAGKKLMQSVKVGEDRDTVRALRALYVRDFDSLEKHHDRYVQCNAPNCSQDDFDGERDWIQAVIYDHQAILAKCDDYLVQTNPKPASTVSRASSRHSSVSSRQARIHEAERKEREAQLMLRQVEDETRRREEEDAKIREAEDYKRKVGSERKQREIRDEIDLQRLSGAIMRQQLNDVTVNDQAAPTRASSVESGLSRVSRVSSHPSIPNNSTLLAKTPAVFTQASTMATTAPMIRPMATPRTQPSAAAISTAAQTQAMTTPLVGSAARMPTPTRLFSQPAATVPSTPRRPFSADYFKLSRPANLHVPHPCHVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9HK32</accession>
    <name>E9HK32_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sen15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_330607</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732667">
        <property type="protein sequence ID" value="EFX67900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67900">
        <property type="protein sequence ID" value="EFX67900"/>
        <property type="gene ID" value="DAPPUDRAFT_330607"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330607"/>
    <dbReference type="HOGENOM" id="CLU_2040386_0_0_1"/>
    <dbReference type="InParanoid" id="E9HK32"/>
    <dbReference type="OrthoDB" id="1522443at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="SSF53032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sen15" evidence="3">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX67900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="121" mass="13831" checksum="B6E2EA694E88D5E3" modified="2011-04-05" version="1">MDLIENIIFRTPKQKALVLQLYKDLKFVRGNEDVKIHQFDELDLVYITGYLPDAERQQEILLPLAADEAISMKKIGEVQKCLFHRHKSSRLTLALMDSDSTTVYFGVTPGLLPPSDLEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9HK98</accession>
    <name>E9HK98_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_260977</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="GL732667">
        <property type="protein sequence ID" value="EFX67847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67847"/>
    <dbReference type="EnsemblMetazoa" id="EFX67847">
        <property type="protein sequence ID" value="EFX67847"/>
        <property type="gene ID" value="DAPPUDRAFT_260977"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_260977"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048483_0_1_1"/>
    <dbReference type="InParanoid" id="E9HK98"/>
    <dbReference type="OMA" id="VENWPMM"/>
    <dbReference type="OrthoDB" id="1094172at2759"/>
    <dbReference type="PhylomeDB" id="E9HK98"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030176">
        <property type="term" value="C:integral component of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102756">
        <property type="term" value="F:very-long-chain 3-ketoacyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="PTHR11157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX67847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="321" mass="37732" checksum="8B4197911A35C0A8" modified="2011-04-05" version="1">MPATTKQQQNPLGEKEHSPNHYSTPCSILSKKKMETSISRIYSEFSFHFVSVYQRVVQFYGWCMSRADPRVAKWPLMASPVPTLLIAMAYLTSIYYGRRFMAKRKPFSIRGILIPYNLAMALLNLYIGLELAVTQHRKQYNWLCQPVNYSEDPDEIRIASALWWYYFSRLVEMMDTIFLVMRKKWQQLTFLHVYHHSTMFMLWWIGVKWVPGGSAFFAAMVNSIIHVAMYLYYALAACGPKVQKYLCWKKYLTILQMAQFVSALVLGVRALIYGCDFPLWMQYALVVYMSSFLFLFGQYYRNAYLLKKQSMGTRLRNITLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKB6</accession>
    <name>E9HKB6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitin-binding type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_260993</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL732667">
        <property type="protein sequence ID" value="EFX67861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67861">
        <property type="protein sequence ID" value="EFX67861"/>
        <property type="gene ID" value="DAPPUDRAFT_260993"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_260993"/>
    <dbReference type="HOGENOM" id="CLU_814480_0_0_1"/>
    <dbReference type="OrthoDB" id="1132954at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="SSF57016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241851" description="Chitin-binding type-1 domain-containing protein" evidence="5">
        <location>
            <begin position="27"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="6">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX67861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="341" mass="37911" checksum="F4E2698F9EA8CD19" modified="2011-04-05" version="1">MLLSERFVVLTIFGAHLLGSIPLCECQRCGSDQPKCPNNLCCSTYGYCGATGEHCCSGCQPQYGHCHPSSVNASTEATNENVVYKSMETLSEIVDGNLLTCRLFPKEIVQKIPIESTHSKIQDIRITTHKIVDIDKTLNNETTHWEKTFNDTIEYGKAVIFLSNLTINVISGSKRFIRLKPLVDLNICEVEVSSFPSGQDESYIKWVAIATSSVIFFLLVILILVVVCFQNHFKNKNSAIDKEHHSNSKNEYSLTDHQRAPRPPGLGFSNPGHSSFNGSEDHADYYEEINYPFVSPLPQLNSNSASDLLGQGVYDEAISLGKVLNKPRFAPPSVPQFPTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9HM81</accession>
    <name>E9HM81_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_302188</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732685">
        <property type="protein sequence ID" value="EFX67151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67151">
        <property type="protein sequence ID" value="EFX67151"/>
        <property type="gene ID" value="DAPPUDRAFT_302188"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302188"/>
    <dbReference type="HOGENOM" id="CLU_1435770_0_0_1"/>
    <dbReference type="InParanoid" id="E9HM81"/>
    <dbReference type="OMA" id="MSDAKTE"/>
    <dbReference type="OrthoDB" id="1850239at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031945">
        <property type="entry name" value="DUF4775"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16001">
        <property type="entry name" value="DUF4775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="189" mass="20779" checksum="8FE83D9C5955DE00" modified="2011-04-05" version="1">MSSEVAEVVSENNQHDAAEAKGKKGLGKKLTALERTTQEGEALLKEMGYKEDGEDQGRRRTRSGARPAAVASPPPAKKEKKTPKKTPKATPGTGRRGRPPKKTVNDSSTENEDSEVKEEEKEEEKEEVSSTEEAKSDTKPTEEAAKEEKKEEKEAEKETKKENNDAAAVIEPVKEKENLSDKEESKASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HN69</accession>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX66785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX66785"/>
        <property type="gene ID" value="DAPPUDRAFT_262546"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_262546"/>
    <dbReference type="HOGENOM" id="CLU_2673587_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
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        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX66785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="75" mass="8189" checksum="477579695ACD8201" modified="2011-04-05" version="1">MHVDAAIATLFCIGAFTPQISAIGGRFLITLQPRNGVSRQTRNLDAQEVESIAATEDLFKGKSTISQRDRNSIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNV3</accession>
    <name>E9HNV3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotrans_gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_116185</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732699">
        <property type="protein sequence ID" value="EFX66584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66584"/>
    <dbReference type="EnsemblMetazoa" id="EFX66584">
        <property type="protein sequence ID" value="EFX66584"/>
        <property type="gene ID" value="DAPPUDRAFT_116185"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_116185"/>
    <dbReference type="eggNOG" id="KOG2415">
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    </dbReference>
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    <dbReference type="InParanoid" id="E9HNV3"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="PhylomeDB" id="E9HNV3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
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        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="213"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX66584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="700" mass="78372" checksum="C8B1015319910250" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9HSV5</accession>
    <name>E9HSV5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX60017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX65184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60017">
        <property type="protein sequence ID" value="EFX60017"/>
        <property type="gene ID" value="DAPPUDRAFT_73041"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX65184"/>
        <property type="gene ID" value="DAPPUDRAFT_65649"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_65649"/>
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    </dbReference>
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    <dbReference type="OMA" id="NMANNTW"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="106" mass="12469" checksum="90C07D6159CA2B16" modified="2011-04-05" version="1" fragment="single">RIDFKIALLTYRCLHCLAPRYLSSLLRLPVSSRLACDRLISMKSRTNTYGCRSFKTYAPQLWNSLPQNVRIASSLAQFRSRLKTHLITVAFRDVIDQRARRERKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9HTB1</accession>
    <name>E9HTB1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Skalitzky C."/>
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                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2006186_0_0_1"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="124" mass="14271" checksum="FCD4F0A1C9B537EE" modified="2011-04-05" version="1">MTQPGRELSWPDYQALREEARNWNVQLLQGAKIRSRCTSVTDMDSPSLYHVRKETTRGRLSMISSLSDGNGELIVDEGRINQILTDSFRQVFVRNLVETPPWRPPSLVESGKWFSHLNFHAQSN</sequence>
</entry>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX64416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX64416"/>
        <property type="gene ID" value="DAPPUDRAFT_334221"/>
    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="110" mass="12676" checksum="F70ADDE1548C631F" modified="2011-04-05" version="1">METMWTEFAADLAPLLWSQFYGVKFLPGQTVMEFMSEVEHIVSRLRAIDGIVLLDNQIIAKITMSLPPKMKLIFKPAWESTAAAERTLRNLTSSSVRKRRWLKHSLAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HWV7</accession>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732966">
        <property type="protein sequence ID" value="EFX63775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX63775"/>
        <property type="gene ID" value="DAPPUDRAFT_267717"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_267717"/>
    <dbReference type="HOGENOM" id="CLU_1397659_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX63775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="195" mass="22675" checksum="473AB6B9B168411E" modified="2011-04-05" version="1">MEKSSPDLTTANMKNDIRELGQIFSHLLSESPQEISQSRVHLIRAMKESVLPSAASILKHPFLWSLEMTTAFLFAARDYYVHHPNFDKISTMNPDQQNLITNRVALQTFSLQMRNLTAEEHNSFVAEWTKKRFPKVVLQTWLRLQKFKEVSSDEDLDLSSFYHPNYDFPAYDEPLDDETIIDIKNDDRSPPQINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HXR2</accession>
    <name>E9HXR2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_335423</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733065">
        <property type="protein sequence ID" value="EFX63468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX63468"/>
        <property type="gene ID" value="DAPPUDRAFT_335423"/>
    </dbReference>
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    <dbReference type="PhylomeDB" id="E9HXR2"/>
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    </dbReference>
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        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX63468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="212" mass="23572" checksum="4A432811F5FFF8AC" modified="2011-04-05" version="1" fragment="single">MVQQLKASRSGTKGHMTRSIGLINGYANKVMNQQEANSLEVLEGKLKGLYETYVIASRDILEKLRASKATQEELDEEQTITLQTQDEVLGARAIIKQKKQEWLDDERDRRLLTLFQATNQASNLAGNQATSQAQMAQLIAQIVAAIPAPPAPVINVTAAPAPASAVQSIRLPQRQIKHFRGDVLEWTQFWESFNAAVHSSSLSNVQKFDYLK</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
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    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX62999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX62999"/>
    <dbReference type="EnsemblMetazoa" id="EFX62999">
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        <property type="gene ID" value="DAPPUDRAFT_67479"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_67479"/>
    <dbReference type="eggNOG" id="ENOG502R7WP">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX62999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="163" mass="18371" checksum="EE36420DF1D85BAF" modified="2011-04-05" version="1">MEPRPVCRFYSKGNCTWGNNCRFVHPGVLDKGNYNMFAPARPSAHNGPAAPYERSFDRPPVVPLIPPAEWANSQPRVANPRPPRHPQPAEPPRTDATGAESPWERGLRQAKEMLKKSSHRKETDIDFEEKKLNLGLGEEELDKENDYYTRPASPVLHGDVPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9I0I5</accession>
    <name>E9I0I5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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            <dbReference type="EMBL" id="EFX61899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="470" mass="53310" checksum="6DE06EB52EAEB028" modified="2011-04-05" version="1">MPTNSFTRNNVKSRQMNAANFNDSLTAAEKATYAVWKQALLDGLTDNTTTARKKEQLKTLKQKETERVRDFKIRIDDTYRIAYGVNAATSRHADVVALRNETLKDVLLNGLKPQIADLVWNRPNLNNKTYPETVESAEECEKVVEMKKIMENNDLSTAIMLAAKESKEMSEEVNNLKLLLQKLESIDTRDAEEQKPNTNQPLKEDQQKENIRRVDPKEEVPPQPPRQVHLPPTQHLAQPHQQVARIGAQAPTLGNIFDDDDDDEMALTNAAVTAWQEAVDRQAEILENGLVFINAQNVKKEIPAFTGEIEGKMALLDGLTDNTTTARKKEQLKTLKQKETERVRDFKIRIDDTYRIAYGVNAAKSRHADVVALRNETLKDVLLNGLKPQIADLVWNRPNLNNKTYPETVESAEECEKVVEMKKIMENNDLSTAIMLAAKESKEMSEEVNNLKLLLQKLESMSVNQQKAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_798272_0_0_1"/>
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        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
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        </location>
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        <location>
            <begin position="12"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
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        </location>
    </feature>
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        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX61850.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="348" mass="38377" checksum="AAB27F287F579ED7" modified="2011-04-05" version="1" fragment="single">MSLIEDETIPETTPVPDTTTETNKEATTPVPDTTTETNKEEYPEILEIKAAETPIINETKVAAASQIKKQNLGNNQPKNLTTVFAGEIAKPDAGINNNSSNPQTMNPTRPTVPPVTAPTKPAQKVTSTTTTTTTTTTTTTSTTTSTSKPIPLTEPTKPPVPHPPKMDANATVLKRTFALVADRKENTVVLLDVEARVRKIPTEVISSSSETVVFQTERKFINNKEQIELEADSLITLHEADPEDEDPLHIDDLYYEDVSSIDSGSTEPNPDLQLNFPSDEKAVSPLPPGLPNNECSGEAEQMYAPPIFLRSEEEYQQNRKDLINQYNRDSPELYRRMAAIRQAIARRP</sequence>
</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="97" mass="10541" checksum="1187FE496F7235FA" modified="2011-04-05" version="1">MKNELEELQAAMQPLIDACYRYPELQCHVRRTVDAFGAVVQTALGSPPPAPRDRTAMAMAAIKKGAPVAPTAREYGLSPSTLFRAIARERERAATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61447">
        <property type="protein sequence ID" value="EFX61447"/>
        <property type="gene ID" value="DAPPUDRAFT_121858"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_121858"/>
    <dbReference type="HOGENOM" id="CLU_175025_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9I3I4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="108" mass="12359" checksum="702744460C7B543F" modified="2011-04-05" version="1">MVRHYIRKTERCMYPDGYILKAVTKVVAESQKVCDVSKATSILKRSLLRYVKNFLAVEIKDEAEATTIIGGHQKPRKVFKSKQESNLRNYVKRASDINHGITTTESQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9I529</accession>
    <name>E9I529_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenosine deaminase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_341054</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="7"/>
    <dbReference type="EMBL" id="GL735365">
        <property type="protein sequence ID" value="EFX60900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX60900"/>
    <dbReference type="EnsemblMetazoa" id="EFX60900">
        <property type="protein sequence ID" value="EFX60900"/>
        <property type="gene ID" value="DAPPUDRAFT_341054"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_341054"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1620708_0_0_1"/>
    <dbReference type="InParanoid" id="E9I529"/>
    <dbReference type="OMA" id="CHASEDK"/>
    <dbReference type="OrthoDB" id="1045809at2759"/>
    <dbReference type="PhylomeDB" id="E9I529"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060205">
        <property type="term" value="C:cytoplasmic vesicle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060169">
        <property type="term" value="P:negative regulation of adenosine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00018099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX60900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="164" mass="18043" checksum="B045FFD8F2C41BB0" modified="2011-04-05" version="1">MLDKEDIVVFEKAVELGIHRTVHAGEAGPAQMVWKALTVMKAERIGHGYRVLEDESIYRHCLDNAVHFECCPTSSLLTGSVSMNGGKPHPITRFAQDGASFSINTDDPTVTNTNLSDEYVLCAQWGLTLAQLQKSNINAMKNSFAEPDVKKAVLEKLYSAYGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9I602</accession>
    <name>E9I602_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_123657</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL736030">
        <property type="protein sequence ID" value="EFX60578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60578">
        <property type="protein sequence ID" value="EFX60578"/>
        <property type="gene ID" value="DAPPUDRAFT_123657"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_123657"/>
    <dbReference type="HOGENOM" id="CLU_699392_0_0_1"/>
    <dbReference type="InParanoid" id="E9I602"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX60578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="395" mass="44690" checksum="724CBB0085E4E25E" modified="2011-04-05" version="1" fragment="single">AVDEAADDDEDDEDDDDDDDDERDIDYADNGDYHDEDRNGERGMSESELDSDSEDEVATEQGDLTEMLVNRAEANAAVNLRDDDDDDDDDEDNLRRVLRLAQEDHTYSCSQTIGGGLSSIVPPGTGSRKRKRGKKIKISSKEWRKKAHYRYSFLYAMVSSGVTKKIKNCIPKAVAILSNSKTIILGHVNLLLECLDPRLAELCYMDTDSCIFSFTHHRLEDNLWPEKLQKWQEENILANEEGEESCHGKLKLEGTFKVGFFKALKIYRLFSSRKFREEQKKKICYTRCKGVNRNIAKIIPNKVFDKDAVEKVVVHRSCLRPSRTGEMLIAHECKSLAAPFNLKRQVSSDGIHTFPVSYLADKAIDGDGSDDDDDDDDEEEVDNDNLGNGSSQEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9FST3</accession>
    <name>E9FST3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein DpuGr50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DpuGr50</name>
        <name evidence="5" type="ORF">DAPPUDRAFT_346897</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89766">
        <property type="protein sequence ID" value="EFX89766"/>
        <property type="gene ID" value="DAPPUDRAFT_346897"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_346897"/>
    <dbReference type="HOGENOM" id="CLU_694966_0_0_1"/>
    <dbReference type="OrthoDB" id="1739394at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="PTHR21143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX89766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="400" mass="46233" checksum="3452B946B98DC981" modified="2011-04-05" version="1">MAGTLKDRFLLSVLSPLSILLKITGVFVIQNAETQWRQSLYRFWTFVVLISAVQSNIYIFVRRTLIIEFLLSGQQINVNRLIQVLLNELIRLSALVSDTIIHLSLVFKIWPSVTLFLETLDSVDLDFGRPNLSPIKRYSIYGLIYVLVTVVLNWIFSIYWDLNHPVRLVYWLDMLQNFIRIFANQGFTVIPVWIFIICGQLCIFYTRKLIANLKLLNFVVRNATGVPSRIVAQQRTFAHLRSLKQLYEAADLLHRHFSTILAVNCFLTVVTMLTSSYYVIEFFKSGRLIVLCWDASDVLDSFVRFWLICHTSDRIRETTTECISVLRSLRDAGNEGNLSECNNKITSYIIEISQIRKNIERHSLKGVLSLSKRLIIPTLEIIFTYLLIIYQFQSAGEGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9FVR1</accession>
    <name>E9FVR1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_310836</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX89059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89059">
        <property type="protein sequence ID" value="EFX89059"/>
        <property type="gene ID" value="DAPPUDRAFT_310836"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_310836"/>
    <dbReference type="HOGENOM" id="CLU_1706042_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="154" mass="17467" checksum="710D3DCF4C1A58C2" modified="2011-04-05" version="1">MIGHFNSFQVLNATISAFDGKSICQAVIVGNGSLNSIFINSASTKEGIRSKKCLRLCSTEKSSCTHCTSQAFYIRKLLKNKSDQKLTGKIRRKTKMQTIERGNRRVMQRNKQLLSGVKTLEQEKEELRIRAKKESLETHLKTLPPQEVIFLLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9FWT8</accession>
    <name>E9FWT8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_42306</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88376"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_42306"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043455_1_0_1"/>
    <dbReference type="InParanoid" id="E9FWT8"/>
    <dbReference type="OMA" id="VIELHAC"/>
    <dbReference type="OrthoDB" id="282791at2759"/>
    <dbReference type="PhylomeDB" id="E9FWT8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX88376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="382" mass="42318" checksum="8693A4F5E57ED9C7" modified="2011-04-05" version="1" fragment="single">VLCNGGGLSQIPDDLPPYVEHLSLIKNNIGQLRTDAFQRYKSLRKLYLDGNAINQVQAFAFRGLGRLQELSMQNTPLERLGAFTFSGLHNLSHLYLANNQIRRIESYAFAGTSSIRLLVLTNNPTVRIDSSAFAGLSDVQMIYLPAGVRHLEQDAFNGLSMVGHLKLAHLDLQSLNSFVFRGLRHVQLLSIQESDLGVIRPGVFTNMSNIGRLSLTNNKIDAIESFELTADNRVRQFHFIGNHVLDLPHGRAIRIRGVPVVNASNNHFPCDCHIFSWMKSAMFANQSRERMMTNNYCISPYEVHGKSIQAAKDEALLLDDCPDDPISDSADDPAEPGSATDIETTLETTKPSTLFSSSDGRSAHQSMAVFMVLLLSSVCVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9FWX1</accession>
    <name>E9FWX1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Electron transfer flavoprotein subunit beta</fullName>
            <shortName evidence="3">Beta-ETF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_305476</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX87969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87969"/>
    <dbReference type="EnsemblMetazoa" id="EFX87969">
        <property type="protein sequence ID" value="EFX87969"/>
        <property type="gene ID" value="DAPPUDRAFT_305476"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305476"/>
    <dbReference type="eggNOG" id="KOG3180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_0_0_1"/>
    <dbReference type="InParanoid" id="E9FWX1"/>
    <dbReference type="OMA" id="YNGGMVP"/>
    <dbReference type="OrthoDB" id="1092876at2759"/>
    <dbReference type="PhylomeDB" id="E9FWX1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
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    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
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        <property type="entry name" value="ETF_b"/>
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    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="4">
        <location>
            <begin position="25"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX87969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="254" mass="27743" checksum="16A058F7B9A48A0C" modified="2011-04-05" version="1">MSLRILVGVKRVIDYAVKIRVKPDKSGVITEGVKHSMNPFDEIAIEEAVRMKEKKIAKEIVAFSCGPAQCQETLRTALAMGADRGIHVEVAGPQFDTLQPLHISKMLAQLAKDEQIDLIIVGKQAIDDDCNQTAQMTAALLDWPQATSASKIEAKDGSLQVVREIDGGLETIKVKLPTVVSADLRLNEPRYATLPNIMKAKKKPIKKLTPKDLGVDVSPRIEVVTVEEPPVRLAGAKVENVDMMVEKLKALGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9FX36</accession>
    <name>E9FX36_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LIM interaction domain (LID) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_42148</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the LDB family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88004"/>
    <dbReference type="EnsemblMetazoa" id="EFX88004">
        <property type="protein sequence ID" value="EFX88004"/>
        <property type="gene ID" value="DAPPUDRAFT_42148"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_42148"/>
    <dbReference type="eggNOG" id="KOG2181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032597_0_0_1"/>
    <dbReference type="InParanoid" id="E9FX36"/>
    <dbReference type="OMA" id="HMSVRTH"/>
    <dbReference type="OrthoDB" id="849287at2759"/>
    <dbReference type="PhylomeDB" id="E9FX36"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030274">
        <property type="term" value="F:LIM domain binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030174">
        <property type="entry name" value="LDB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041363">
        <property type="entry name" value="LID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="PTHR10378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378:SF8">
        <property type="entry name" value="PTHR10378:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17916">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51957">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LIM interaction domain (LID)" evidence="4">
        <location>
            <begin position="302"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="391"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX88004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="430" mass="47857" checksum="6F773EEDD588C7DD" modified="2011-04-05" version="1">MGGPGERIDQHPGGPPFFNRRHPGPYFNQPDYRIYELNKRLQQRTEESDNLWWDAFATEFFEDDATLTLTFCLEDGPKRYTIGRTLIPRYFRTIFEGGVTELNYQLRHAKESFHQTTITLDCDQCTMVTQHGKPMYTKVCTEGRLILEFTFDDLMRIKSWHFAVRTHRELVPRSVLGSQDPSLLDQMSKNVTRQGITPATLNYLRLCVILEPMQELMSRHKAYALSPRDCLKTTLFQKWQRMVAPPGKRISSNIYKTQRPPNKRRKRKGSQTGGGAGINQAQPAAPNKKRSPGPNFSLASQDVMVVGEPSLMGGEFGDEDERLITRLENTQYDPAVSLDDPSGGGGGGPPSAPPSQFNSGPPGKYRSLKLRHFFLVSIDCKVTFSSNQLNLAAGPQGPNDPSPWGVVPKQGGGNKGGGGDAGKKSPAVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYU1</accession>
    <name>E9FYU1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_96762</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87594">
        <property type="protein sequence ID" value="EFX87594"/>
        <property type="gene ID" value="DAPPUDRAFT_96762"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_96762"/>
    <dbReference type="HOGENOM" id="CLU_1735988_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX87594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="151" mass="15393" checksum="29B9E774C3CA675B" modified="2011-04-05" version="1" fragment="single">DDCLGSDNGLPTTPINGASSSSGHVLHHHHGGVGGSDLLSELKPNSFTLGNKLLFDDGVHNPSGSGGLMAASRTMSSLMASQFGGGSKDPHASSLLSHLPSAAFASYHPSGSHGYDGGSVATLANLHVAHQHVVQPSSLYHGHRDQAFSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZR7</accession>
    <name>E9FZR7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_312635</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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                <person name="Yamagata H."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="EFX86778.1"/>
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        <location>
            <begin position="1"/>
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        </location>
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    <feature type="chain" id="PRO_5003240522" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
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        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX86778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="248" mass="27733" checksum="8DB7C412CEE62D3D" modified="2011-04-05" version="1">MAVLMTVLAYCQPASAAATAVTDDDELMARQTRGLVLRSWRNAQQQTDHSADKTPSAKVAEPILPSQKEAMVFNGLPISMRLVLLQHLAGYDKRTPNSRAFLGMRGKKSSPPGADALTMEDNQLDDASGWPQGDILPDTYYFGPAPQKKKMHGEKFLGMRGKKMMNGLADGTAFIPNWRERYIYQEPFEKKRAPSSNSFMGMRGKRSESTTPTPNDYQFFNDDIIVDEELPDVDSKVSPRRSQERTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9G248</accession>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="4">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732530">
        <property type="protein sequence ID" value="EFX86367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86367"/>
    <dbReference type="EnsemblMetazoa" id="EFX86367">
        <property type="protein sequence ID" value="EFX86367"/>
        <property type="gene ID" value="DAPPUDRAFT_222176"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_222176"/>
    <dbReference type="eggNOG" id="KOG0796">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030397_3_1_1"/>
    <dbReference type="InParanoid" id="E9G248"/>
    <dbReference type="OMA" id="LGYVKMR"/>
    <dbReference type="OrthoDB" id="1499212at2759"/>
    <dbReference type="PhylomeDB" id="E9G248"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site selection"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="PTHR12375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX86367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="325" mass="38219" checksum="9120CF331FC34D6E" modified="2011-04-05" version="1">MSAKDQMRAMLDQLMGTTRDGESSRYNVKFSDPKVCKSFLLGCCPHEILASTRMDIGECVNIHDLALRADYEKASETKDYGYQVDAMDHLTTFVGECDRKTEAAKKRLAETQEELSAEVAAKAQKVHLLAEQIGQKLAKAEQLGAEGFVDESMKMMEEVEEFRKKKATAEQEYRNAMPASSYQQQKLRVCEVCSAYLGIHDNDRRLADHFGGKLHLGFIKIREKLAELQVKVEERRRQRHTQPVADDREKQRERQREREREDRERERERERERDRRRERRRSRDRSPERPRDRRQDGRNRPRSPVSRNHRQRSSSRDSGIHPENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3S9</accession>
    <name>E9G3S9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_98469</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85824">
        <property type="protein sequence ID" value="EFX85824"/>
        <property type="gene ID" value="DAPPUDRAFT_98469"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_98469"/>
    <dbReference type="HOGENOM" id="CLU_1220788_0_0_1"/>
    <dbReference type="OrthoDB" id="1751790at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX85824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="227" mass="24420" checksum="82D755C20A065BF6" modified="2011-04-05" version="1">MPLAKPLAHYGFSLSGGYEAQHSRESVDLIGGVNNSVAVTSVAGTVGSSGSTVVGVGHGSGGEVDVWSNSHDPYSPHNHHHHQQQQQQQQHHHQHHHQQQQHAAYYGQSVGGGQVMTELLTATHPPSSYNLNQPQQQQQQQQQQQQQQPFTPTEQHPVDLSNSQQRPPNPAVSAATSAAFYGLSAADYNSPATSSSQRQRGGNDTYKPNGLSLSLGIPDSGKYSQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E9G429</accession>
    <name>E9G429_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BK channel</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Maxi K channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_313756</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85873"/>
    <dbReference type="EnsemblMetazoa" id="EFX85873">
        <property type="protein sequence ID" value="EFX85873"/>
        <property type="gene ID" value="DAPPUDRAFT_313756"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_313756"/>
    <dbReference type="eggNOG" id="KOG1420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006846_0_0_1"/>
    <dbReference type="InParanoid" id="E9G429"/>
    <dbReference type="OMA" id="IKKLMPS"/>
    <dbReference type="OrthoDB" id="124461at2759"/>
    <dbReference type="PhylomeDB" id="E9G429"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060072">
        <property type="term" value="F:large conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024939">
        <property type="entry name" value="Ca-act_K_channel_Slo-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF28">
        <property type="entry name" value="PTHR10027:SF28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans" evidence="11">
        <location>
            <begin position="25"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="BK_channel_a" evidence="12">
        <location>
            <begin position="393"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX85873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1028" mass="115681" checksum="6C945AFFE4142359" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7H8</accession>
    <name>E9G7H8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_314795</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TALE/MEIS homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84465"/>
    <dbReference type="EnsemblMetazoa" id="EFX84465">
        <property type="protein sequence ID" value="EFX84465"/>
        <property type="gene ID" value="DAPPUDRAFT_314795"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_314795"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023139_0_0_1"/>
    <dbReference type="InParanoid" id="E9G7H8"/>
    <dbReference type="OMA" id="SKWIESE"/>
    <dbReference type="OrthoDB" id="1221551at2759"/>
    <dbReference type="PhylomeDB" id="E9G7H8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="Homeobox_KN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032453">
        <property type="entry name" value="PKNOX/Meis_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16493">
        <property type="entry name" value="Meis_PKNOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="241"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="3">
        <location>
            <begin position="243"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX84465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="356" mass="39366" checksum="B0849A58DB89FE76" modified="2011-04-05" version="1">MERVDGLLLSGAQQQHQYFNSSDHATAAHKGMDMEYNAISGVKVQDRVQFEADKQAVYRHPLFPLLALLLEKCEEATRGEVDTRVVLQGLENDVRAFVQHERDGNKTLMTDNAEVDGLMLKALQVLRIHLLELEKVQELCRDFCRRYIACLRGKLHSENLLRTEGESGGLDGDEAGYDSNCSNGSGSHPFNLDAVAASYSSQYRRDESTHQPSSRPSQVSYVQSSLSSDEEEDAVGGNPNPSAKVKRGVLPRKATAVLRSWLFQHLVHPYPTEEEKKQLATQTKLTLLQVNNWFINARRRILQPMLDSAHATHAGSASLQPDVDFTPKRMLISGAGSSSGPGSDGEDALSYGDSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7I9</accession>
    <name>E9G7I9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Component 3 of promoter of RISC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_194468</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84471"/>
    <dbReference type="EnsemblMetazoa" id="EFX84471">
        <property type="protein sequence ID" value="EFX84471"/>
        <property type="gene ID" value="DAPPUDRAFT_194468"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_194468"/>
    <dbReference type="eggNOG" id="KOG3067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079179_0_0_1"/>
    <dbReference type="InParanoid" id="E9G7I9"/>
    <dbReference type="OMA" id="LHAGFQI"/>
    <dbReference type="OrthoDB" id="1187354at2759"/>
    <dbReference type="PhylomeDB" id="E9G7I9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="PTHR10741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741:SF2">
        <property type="entry name" value="PTHR10741:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="SSF74784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX84471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="226" mass="26092" checksum="F5E09F8A1D070917" modified="2011-04-05" version="1">MDLATVFAQYQNLLDADQDLREEIRLIVRELDTTGREVSLILQQIHQEDGLNQIGELCTRAKLTLSKANEQFSKLASKIPPNQYFRFNDHWRYVMQRYSFLCALIFFLESEKLALHSDVGKLLEVSIKEEDGFHLDVEDYLSGLLQLASELSRLAVNSVTAGNYDLPIRISRFVSELNGGFRLLNLKNDSLRKRFDALKYDVKKIEEVVYDLSIRGLRSRSLTITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7W3</accession>
    <name>E9G7W3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_223019</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84592">
        <property type="protein sequence ID" value="EFX84592"/>
        <property type="gene ID" value="DAPPUDRAFT_223019"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_223019"/>
    <dbReference type="HOGENOM" id="CLU_772243_0_0_1"/>
    <dbReference type="OrthoDB" id="1494583at2759"/>
    <dbReference type="PhylomeDB" id="E9G7W3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="359" mass="40946" checksum="71F7FCB00D8DD7D0" modified="2011-04-05" version="1">MSRAQIYRKIYGYYLTLIGIEIDMTSQKIKVQTIFFVQNVNQFQKDDTDEDFDFQFDFSFELDFESLVALDHTSQLHKDIRLFEIQNSEKAANKQHSAPPANISSAPPKKLHSIPARPFLIARVRDSVAISSITESKIDNLLGSVKDQEGPVVQQLKKHSDNSVKIFFRNEQNRDKARQLLDKPEEEKVFQNVHAPQNCYPAILRLNGVNGLGRIREDGVISNIDLFNARTKQKCGLINKLQTENPVLKGKIAGVRILFNREDFSLVRLSLHFKTTRDHYLELGRIQLGNKAHTVVEVDVNKEVRFCTRCQGYGHLSKFCSKPITCGNCTHNLDSEMQDDIDENALFCGTPSVEGQKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7X6</accession>
    <name>E9G7X6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_238980</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84559">
        <property type="protein sequence ID" value="EFX84559"/>
        <property type="gene ID" value="DAPPUDRAFT_238980"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238980"/>
    <dbReference type="HOGENOM" id="CLU_601662_0_0_1"/>
    <dbReference type="OrthoDB" id="1696991at2759"/>
    <dbReference type="PhylomeDB" id="E9G7X6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX84559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="455" mass="51608" checksum="0825E147F5BCBD2B" modified="2011-04-05" version="1">MKGIQASLKSSTYPRMKKVILVHLNHPKIVVYSSGRQQKLKLVPQNLNKVRVMNNKDVNGEETILSASSLLEMSPMQPKRSDMDHIQHDAILSALRGIRGEGVTCEAVMKDNMEHFKKVVKSQVSLPILVPEEISVLNAALCDMELSICLIQNLRTLGSKDKIAKAVLIAIFSRALCSKVQWKKRGKDLRIGIGHLINLVAVFGVVINKVLEMHKQPQLAVSAVVCAVQNARRYHGYEYAKSVTAAACSSTEIDELDDEEECHSRADKEKNMAIDRRMLELNKAILEYNPPNGVDHPEMRIMHGIQVIRWLRNTSVGVFTFSDAACNLGREFRFVTDKEFSLSQWNILFSFIRAFATIVTIPSPSAKWPGLRKRSQSSSRSCFMLIIKLSQPTKIRQLPSDSVARRPRRDIWASLFIDKRQQWTIRISSTSDMRSYTGKKPLLRKIIRYRSTNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9D9</accession>
    <name>E9G9D9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_315316</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83893"/>
    <dbReference type="EnsemblMetazoa" id="EFX83893">
        <property type="protein sequence ID" value="EFX83893"/>
        <property type="gene ID" value="DAPPUDRAFT_315316"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315316"/>
    <dbReference type="eggNOG" id="KOG0989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_0_7_1"/>
    <dbReference type="InParanoid" id="E9G9D9"/>
    <dbReference type="OMA" id="CYVADLP"/>
    <dbReference type="OrthoDB" id="649530at2759"/>
    <dbReference type="PhylomeDB" id="E9G9D9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022107">
        <property type="entry name" value="DNA_pol_III_gamma/tau_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12362">
        <property type="entry name" value="DUF3646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="60"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX83893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="556" mass="61901" checksum="87C1A4C2FC459C52" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAL6</accession>
    <name>E9GAL6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_315722</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83269"/>
    <dbReference type="EnsemblMetazoa" id="EFX83269">
        <property type="protein sequence ID" value="EFX83269"/>
        <property type="gene ID" value="DAPPUDRAFT_315722"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315722"/>
    <dbReference type="eggNOG" id="KOG0517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1504951_0_0_1"/>
    <dbReference type="InParanoid" id="E9GAL6"/>
    <dbReference type="OMA" id="WPRNDTR"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX83269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="179" mass="20667" checksum="221EDED669B0A15C" modified="2011-04-05" version="1">MTMFDWPRNDTRTSRTRSCSSLSTFNGECDDFDKWLQEKAKQLNADNRGDTVDAAKRKFEQIVTDLSASRSRLDEIDRRADELLAVKAAAPANIRARVNKSIHHDRSDSIKKLRQAKERSLQGANSVEELFHRTCDEATEWMEEKITKLDTEELGRDLQSVQALQHRHQNLERELAPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9GB21</accession>
    <name>E9GB21_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dual-specificity kinase</fullName>
            <ecNumber evidence="5">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DAPPUDRAFT_915</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="5"/>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83360"/>
    <dbReference type="EnsemblMetazoa" id="EFX83360">
        <property type="protein sequence ID" value="EFX83360"/>
        <property type="gene ID" value="DAPPUDRAFT_915"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_915"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_5_15_1"/>
    <dbReference type="InParanoid" id="E9GB21"/>
    <dbReference type="OMA" id="HPFLMSM"/>
    <dbReference type="OrthoDB" id="870358at2759"/>
    <dbReference type="PhylomeDB" id="E9GB21"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018105">
        <property type="term" value="P:peptidyl-serine phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018107">
        <property type="term" value="P:peptidyl-threonine phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046777">
        <property type="term" value="P:protein autophosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14226">
        <property type="entry name" value="PKc_DYRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028318">
        <property type="entry name" value="DYRK1A/B_MNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044131">
        <property type="entry name" value="PKc_DYR1A/1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF121">
        <property type="entry name" value="PTHR24058:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="98"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFX83360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="498" mass="55970" checksum="65D570607BB6DEEA" modified="2011-04-05" version="1" fragment="single">SAAGSSSDLQTMQSRIPRQFRDPASAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQQAPGEDSGQQHNKKERKVYNDGYDDDNHDYIVRHGERFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAVKIIKNKKPFLNQAQIEVKLLEMMNKADAENKYYIVRLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIPYDLAIDIWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGMPPRAMLDSAHKTKKYFDKLPDGSYVLKKSKEGKKYKAPGHRRLHDIVGVESGGPGSRRSGEIGHFVSDYLKFKDLILRMLDYDPKTRITPYYALQHNFFKRTADEGTNTHNNSASTTVAAGRRYASHLDASGGGGVGLQVLNSGNPSVFASGSSAFIGSSSAFSVGSNSAATYSNLGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GB40</accession>
    <name>E9GB40_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_100684</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83434">
        <property type="protein sequence ID" value="EFX83434"/>
        <property type="gene ID" value="DAPPUDRAFT_100684"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_100684"/>
    <dbReference type="HOGENOM" id="CLU_1612460_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX83434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="165" mass="18371" checksum="4995811763686AC2" modified="2011-04-05" version="1">MRSLSAYHSKILYLKLLLQSIWKLIGDKGRFFFFRLQRQTVGVLAQMNEIAVANQNFTPADRPAGQLACPSRLKVAGNITCKTRCGSVEVGQRLGENWTFFVLHHYQTDPSKVTEIITLNVPCDGGVTSTGPLLVKGSPSRVELQLLKQSTMLVLFRNVTSMKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBW4</accession>
    <name>E9GBW4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_316155</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732538">
        <property type="protein sequence ID" value="EFX83085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83085">
        <property type="protein sequence ID" value="EFX83085"/>
        <property type="gene ID" value="DAPPUDRAFT_316155"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_316155"/>
    <dbReference type="HOGENOM" id="CLU_1134545_0_0_1"/>
    <dbReference type="InParanoid" id="E9GBW4"/>
    <dbReference type="OrthoDB" id="1115202at2759"/>
    <dbReference type="PhylomeDB" id="E9GBW4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX83085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="245" mass="27748" checksum="191FA6ACE8880A4E" modified="2011-04-05" version="1">MDTVELGLLLNHKDTNVNCLDNEGHHSALDYAKVNTHGHGERIAIRLKTKGAVERENKQLQGTNEIMKKHMRAFSNDKLRKFAKFLSDDTKTIEAKIEKISERKEYVVSAIRDSNVASIRILLKSGADNQGNNALYYAKVNMFGHGKRITKLLEEKGVGSQTGKDEKVENEVTFENNVKGILQKAFQDSEVGMARFLIHIGVDISTVTWGKKDGMHFTWLPFVQRRPKYLTSFWQPVNSTSKVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9GCS2</accession>
    <name>E9GCS2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_240861</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732539">
        <property type="protein sequence ID" value="EFX82817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82817">
        <property type="protein sequence ID" value="EFX82817"/>
        <property type="gene ID" value="DAPPUDRAFT_240861"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_240861"/>
    <dbReference type="eggNOG" id="ENOG502RTCE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_757065_0_0_1"/>
    <dbReference type="InParanoid" id="E9GCS2"/>
    <dbReference type="OrthoDB" id="825016at2759"/>
    <dbReference type="PhylomeDB" id="E9GCS2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX82817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="366" mass="41723" checksum="6863B448C969ECE8" modified="2011-04-05" version="1">MGIECQQLEIIPGDSERVVQAGSHLTLTCTYRYVNEYDKRENNISWILPSYLTRNPKSGVEKRLLKTFNRNDTHLSSTMTLMNSTPEDTGYFGCVEILSWNTIGKISQYVYVHSDTTLIIDKMDDKYLFPKFEHRQGESLLIPCKPTHPNVTVSLSREKLSTNGEWDWDNITDLLSQPDSNWAFEPKLGMTLTNPKINDSGEYGCVGKMDNAVIYEYFSIYVLGRMELTRIDEIDDTLQAWLDGSNATFICRTSATSEFPSQPEWAYQIGDDGEMHVLNESNPTGEIRYDPVVYYVRNQEENNSTVIAFSVTLAILFAIGICIAVKPYFDKKRSGFREKVENKLESPIEEQTELITTSYGAADFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEW2</accession>
    <name>E9GEW2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipocln_cytosolic_FA-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_302799</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732541">
        <property type="protein sequence ID" value="EFX82011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82011">
        <property type="protein sequence ID" value="EFX82011"/>
        <property type="gene ID" value="DAPPUDRAFT_302799"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302799"/>
    <dbReference type="eggNOG" id="KOG4824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068449_2_0_1"/>
    <dbReference type="InParanoid" id="E9GEW2"/>
    <dbReference type="OMA" id="KNAINNE"/>
    <dbReference type="OrthoDB" id="1631943at2759"/>
    <dbReference type="PhylomeDB" id="E9GEW2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031409">
        <property type="term" value="F:pigment binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003057">
        <property type="entry name" value="Invtbrt_color"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01273">
        <property type="entry name" value="INVTBRTCOLOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013437383" description="Lipocln_cytosolic_FA-bd_dom domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocln_cytosolic_FA-bd_dom" evidence="4">
        <location>
            <begin position="41"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX82011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="224" mass="25746" checksum="1777F587099A1ADD" modified="2011-04-05" version="1">MPIHNKFLVVFVTAVQLLSPRVQSQVTFDQPCPKLDVVRDFDLHRYLGLWYEIESYPAVFSSFASCVTANYSLLADGNVRVINRSFNTSSKSFNMVDGIARLIEPPKGQAKLGVVFPSNSFSRPVPADGNYWVLDTDYTNYSIVWSCQTFNGKSIQFLWYLSRQRQPSESGLTFVHHRIDSFGLDQKFLKTMEQRNCPDAPASETSRPIRQQQPTRTSYYYREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9GGD2</accession>
    <name>E9GGD2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_128207</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732543">
        <property type="protein sequence ID" value="EFX81517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81517"/>
    <dbReference type="EnsemblMetazoa" id="EFX81517">
        <property type="protein sequence ID" value="EFX81517"/>
        <property type="gene ID" value="DAPPUDRAFT_128207"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_128207"/>
    <dbReference type="eggNOG" id="KOG1888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_0_3_1"/>
    <dbReference type="InParanoid" id="E9GGD2"/>
    <dbReference type="OMA" id="KRKCCAH"/>
    <dbReference type="OrthoDB" id="359616at2759"/>
    <dbReference type="PhylomeDB" id="E9GGD2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="PTHR45738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="3">
        <location>
            <begin position="154"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="696"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX81517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="867" mass="98927" checksum="DB30AFF4A419048B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIW7</accession>
    <name>E9GIW7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_303993</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80335">
        <property type="protein sequence ID" value="EFX80335"/>
        <property type="gene ID" value="DAPPUDRAFT_303993"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303993"/>
    <dbReference type="HOGENOM" id="CLU_1637131_0_0_1"/>
    <dbReference type="OrthoDB" id="1860045at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237499" evidence="1">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="162" mass="17549" checksum="5A3AF71BF7D7BC4E" modified="2011-04-05" version="1">MSATKVMAVLVLVLAVAMAVSTDGNKNKTNTSHAQHVGSLVAKARLSPVNATVNNITSTESNKNSTTAEKTVTKRSLGSIDKSDGTSQLMSVWWRIPTAIWDFVSQVFLQPLLSSLRRLLSVFGLYNEQMMPLPLAVPSSSPLDFVSQFVPQFTTPINPMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJ67</accession>
    <name>E9GJ67_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_318561</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80394">
        <property type="protein sequence ID" value="EFX80394"/>
        <property type="gene ID" value="DAPPUDRAFT_318561"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_318561"/>
    <dbReference type="HOGENOM" id="CLU_1612467_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="165" mass="18196" checksum="84C66920FE5578CB" modified="2011-04-05" version="1">MINLLIFGFDSKRKKTQPSPLTVVQPQPKVSVSGLYSGDTSTPITATLRRIPINPLARPSCRRVVPIQSPTLAPVQNSPPPPPMPPPTPPPRQQTASTSPHKISSGGSGGNNNEESPMSQQQQQYPHQHHRTFLSSSQSTVWPTDASLPRRVKKLSWEDEFNVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJR5</accession>
    <name>E9GJR5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_318822</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732548">
        <property type="protein sequence ID" value="EFX80156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80156">
        <property type="protein sequence ID" value="EFX80156"/>
        <property type="gene ID" value="DAPPUDRAFT_318822"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_318822"/>
    <dbReference type="eggNOG" id="ENOG502QW9Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1355878_0_0_1"/>
    <dbReference type="InParanoid" id="E9GJR5"/>
    <dbReference type="OMA" id="VIRCICH"/>
    <dbReference type="OrthoDB" id="238769at2759"/>
    <dbReference type="PhylomeDB" id="E9GJR5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX80156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="202" mass="23189" checksum="D479178AD8D9DF6C" modified="2011-04-05" version="1">MAVVLSFWDGKFNSEMLKMKRCKDATAEGLFTALIAELAKSKIPESQMVGFSADTCNIMFGENNSVSQKLRALIPHLLTVKCSCQSCHLCSSKAFAMLPTLIEEFLRQLSAFFTSSYKNKYEFAEFQEFCETAAHSILIPGLTRWLTLQPCAARVLEQSTSLQNERKMRVEIMNNKNKMERIRMTIQSYKRKEYLRVPLDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJT9</accession>
    <name>E9GJT9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EOG090X06Q3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EOG090X06Q3</name>
        <name evidence="7" type="ORF">DAPPUDRAFT_304182</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TCO</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732548">
        <property type="protein sequence ID" value="EFX80170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015265">
        <property type="protein sequence ID" value="SVE84884.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80170"/>
    <dbReference type="EnsemblMetazoa" id="EFX80170">
        <property type="protein sequence ID" value="EFX80170"/>
        <property type="gene ID" value="DAPPUDRAFT_304182"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304182"/>
    <dbReference type="eggNOG" id="KOG2890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043563_2_0_1"/>
    <dbReference type="OMA" id="FACLFPD"/>
    <dbReference type="OrthoDB" id="1156492at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PTHR13377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX80170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SVE84884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="360" mass="40208" checksum="F2332632F4F2D9BF" modified="2011-04-05" version="1">MAALKTLHRNVPYLKQQLYALLGNTSSSVKIVCLMVFIGYFVSYYEPAVLFLTVTPGYVFPPGFRIWTIFTHCFVEFHFWEVCVDVVTIGLCGKLIEPLWGKMEMLTFFTLINTSVAFFGVFFYLAIYMATFNTDVLFEVHIHGLSGYIAAVSVAVKQMMPDHVVIRTPLGKMTNRNVPLCVSLLSIILYLVGLLEGAYPTMYTTGVVIGWLYLRFYQRHSNGTRGDMADNFTFASFFPTVMQPPIEICSKFVYNLLVGIKVCRKPVRKYDVGAPTAITISLPGTDTHDAERRRQIALKALSERLSQQADSGSSWPSLDDDSRPKTEVQAEDQSSPASNPVEPLTVAVEIDPSTSKPSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKI2</accession>
    <name>E9GKI2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ULP_PROTEASE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_319040</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732549">
        <property type="protein sequence ID" value="EFX79997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79997">
        <property type="protein sequence ID" value="EFX79997"/>
        <property type="gene ID" value="DAPPUDRAFT_319040"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_319040"/>
    <dbReference type="HOGENOM" id="CLU_1397648_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ULP_PROTEASE" evidence="1">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX79997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="195" mass="21323" checksum="5FA494B109067C31" modified="2011-04-05" version="1">MPSCPQPGVTAVIVVSLKIYDSIAKSYTAYKIVINRVHAYVRKALHCRYDPQVADLLLPVRNISVEFPTQTSGSQDCGAFVIYYAVKLLICGNPAATHMLESESRSAVDYGSLTRRSLKQLSELLKDLPSMLSTIIRQEKLAAIRLAFVDGSATQLDGCHHSTTPSHFSSPAHGKKCNVPFDDNIGEGKSPNLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9GLH8</accession>
    <name>E9GLH8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_244669</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732551">
        <property type="protein sequence ID" value="EFX79695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79695"/>
    <dbReference type="EnsemblMetazoa" id="EFX79695">
        <property type="protein sequence ID" value="EFX79695"/>
        <property type="gene ID" value="DAPPUDRAFT_244669"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_244669"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388957_0_0_1"/>
    <dbReference type="InParanoid" id="E9GLH8"/>
    <dbReference type="OMA" id="ALHISCK"/>
    <dbReference type="OrthoDB" id="581716at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="269"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="383"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="494"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX79695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="710" mass="83035" checksum="A542831712271154" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GM39</accession>
    <name>E9GM39_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_244900</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732552">
        <property type="protein sequence ID" value="EFX79457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79457">
        <property type="protein sequence ID" value="EFX79457"/>
        <property type="gene ID" value="DAPPUDRAFT_244900"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_244900"/>
    <dbReference type="HOGENOM" id="CLU_2280205_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX79457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="102" mass="11615" checksum="3ED4405BA6659308" modified="2011-04-05" version="1">MIPVTVGGCRHAKVIIISGLKLSRQEEEEEEKNCWRLGNFCLGFSLLFSTSFTYTQSLSYTIIEIQLQARTNWKFEIRAKNENDSGSFLSIIIIIRSLPTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9GNC7</accession>
    <name>E9GNC7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_305046</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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    </evidence>
    <sequence length="427" mass="47456" checksum="B1D3F355627676E5" modified="2011-04-05" version="1">MLFWKEPRTQLVKVQIADSLLLKLVFASALRPLEQALRSILGSPSTPYHFGSKSSQLPLGRRIGKSARKDSGNVKFSIDAASHGQWNGRTTTMGYSVLYWAKIGFRVSDGGSEVQGRNAPKIMRVRGDRKPNLFQCDRSVKTTEPSCPTFNVEPFLRTSATFPLQLPMALDSSELRSPSAGTEPPSYSQSHRTSSDFLRIIMNKSIQLRSSFENFVPESHQSEEVNVLEILGFASIALTSDPFQSPAEGKAHPSQATTTCTCLCLWKGTPIPSNVNLKKERAVRLSFTFEGHGDHYEKLLIQWCRGWVRKEREKARDISRVSISDTATTAVPYPSPSAFFTVLPVRIHGKHMASCCCCVLYLMAGSTTGVPMSSWYGVTKPQRRRLTTQKQLTQRPVTASRSTSTTLLSHRSFIPQLTLPRATTLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GU64</accession>
    <name>E9GU64_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_248327</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732565">
        <property type="protein sequence ID" value="EFX77028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77028">
        <property type="protein sequence ID" value="EFX77028"/>
        <property type="gene ID" value="DAPPUDRAFT_248327"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_248327"/>
    <dbReference type="HOGENOM" id="CLU_2592208_0_0_1"/>
    <dbReference type="OrthoDB" id="1870687at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="80" mass="8772" checksum="8325C836C2369250" modified="2011-04-05" version="1">MVQESGSKSFMNVNTAVSRKDTGYVSDPMAGRTHSQVGVKQQYGSSSSSSSSSQKMDSQKYGAWGPVYKNKDHFANMHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9GUA1</accession>
    <name>E9GUA1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_305987</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732565">
        <property type="protein sequence ID" value="EFX77010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77010"/>
    <dbReference type="EnsemblMetazoa" id="EFX77010">
        <property type="protein sequence ID" value="EFX77010"/>
        <property type="gene ID" value="DAPPUDRAFT_305987"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305987"/>
    <dbReference type="eggNOG" id="KOG4076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125025_1_0_1"/>
    <dbReference type="InParanoid" id="E9GUA1"/>
    <dbReference type="OMA" id="SKYPGGM"/>
    <dbReference type="OrthoDB" id="1494565at2759"/>
    <dbReference type="PhylomeDB" id="E9GUA1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035308">
        <property type="term" value="P:negative regulation of protein dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="PTHR10358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX77010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="127" mass="13768" checksum="9534540E2BAD0C15" modified="2011-04-05" version="1">MASEESSTIPKENQVTQSNEETETMASQRDIEKLEEEKLKARYNARPVTGHSAFLQKRLAKGQKYFDSGDYQMAKQKGPAKIPTAAATAVIPPANLGHPTGDAIPTPESVPTRKTSIIQSKLASPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GUG2</accession>
    <name>E9GUG2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_248586</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732566">
        <property type="protein sequence ID" value="EFX76850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76850">
        <property type="protein sequence ID" value="EFX76850"/>
        <property type="gene ID" value="DAPPUDRAFT_248586"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_248586"/>
    <dbReference type="HOGENOM" id="CLU_1817735_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="142" mass="14969" checksum="5DDDE5CADD3E6963" modified="2011-04-05" version="1">MPQLAEVGVVTSVVAMDEMSWSTVGGHKIGHWFASLGSRGRGRRKAAAVAAAAAAANSANNGVANNNTTRSFTLDKESETTSKAFRFTVRCRLAAFYALSYSPVRCGFAKFMRSGGGPHIRTINETRGSASIRNGNDPTLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GUX3</accession>
    <name>E9GUX3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_248641</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
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    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Shaw J.R."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Basu M.K."/>
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            <begin position="125"/>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="195" mass="23065" checksum="76F4F9928B7E7F87" modified="2011-04-05" version="1">MSSRARSPSVESVPEISRHLNDDIYGNLDFPVAGVQIRSPRATRSSRACSRQHGLFSCLLSASSDRAFLEYRCSRDRSPLKRPTSVEHDGQFREQGRYDDGRYSNDRYFDVDRQDYRGESGPCRWAGYPARRFSPGNHEFNDRQWGHEDYSYNRFRLNEEWGRNEAFWRNQSWHGDRFHPPDLRYDLDWRLGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZ93</accession>
    <name>E9GZ93_DAPPU</name>
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        <recommendedName>
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        </recommendedName>
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        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
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                <person name="Shiga Y."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPL4 family.</text>
    </comment>
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    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_306878"/>
    </dbReference>
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    <dbReference type="PhylomeDB" id="E9GZ93"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Npl4"/>
    </dbReference>
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        <property type="entry name" value="NPL4_C"/>
    </dbReference>
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        <property type="entry name" value="Npl4_Ub-like_dom"/>
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        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RANBP2_1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="240"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX75107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="620" mass="69189" checksum="AD40F053FC3264C2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0R2</accession>
    <name>E9H0R2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732581">
        <property type="protein sequence ID" value="EFX74689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74689"/>
    <dbReference type="EnsemblMetazoa" id="EFX74689">
        <property type="protein sequence ID" value="EFX74689"/>
        <property type="gene ID" value="DAPPUDRAFT_56750"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_56750"/>
    <dbReference type="eggNOG" id="KOG3510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046341_3_4_1"/>
    <dbReference type="InParanoid" id="E9H0R2"/>
    <dbReference type="OMA" id="MVSWIKR"/>
    <dbReference type="OrthoDB" id="1051626at2759"/>
    <dbReference type="PhylomeDB" id="E9H0R2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="PTHR23279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="93"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="257" mass="28632" checksum="50EEBF0EDBDD8A39" modified="2011-04-05" version="1" fragment="single">FLTPNGTLITAQRGTPASLPCEVVSLGDGVVTWFRRKDFHLLTVGHAVYSSDERFHVQGPMRSTQTQDWALQIRFVQERDSGLYQCQLSTHPPSSLFVELVVVEAHAEIDGGPEKYVKSGSTLKLTCHLRQSSVTPDFVFWYQDERMINYEGAAGVKVISDAASSTLIIERAQSVHSGNYSCVPYNVNPSSVIVHILNGKKEKIPSRHRLLSSKLSSVILFLHVVHCNPLDFTLSLSLSMCSRRHSNFTSSPSYIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9H187</accession>
    <name>E9H187_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_324371</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="domain">
        <text evidence="4">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732583">
        <property type="protein sequence ID" value="EFX74398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74398"/>
    <dbReference type="EnsemblMetazoa" id="EFX74398">
        <property type="protein sequence ID" value="EFX74398"/>
        <property type="gene ID" value="DAPPUDRAFT_324371"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_324371"/>
    <dbReference type="eggNOG" id="KOG0819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025300_0_0_1"/>
    <dbReference type="InParanoid" id="E9H187"/>
    <dbReference type="OMA" id="CMEGMGT"/>
    <dbReference type="OrthoDB" id="856254at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="SSF47874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX74398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="330" mass="36311" checksum="A4D8C4747F7913D0" modified="2011-04-05" version="1">MSLTGDMEEYVEVPTVLPAANFDPVADAHALRAAMKGFGTDEQVIIDILCQRSNAQRQAITEAYKKEFGRDLIADLKSELGGNFENVIIGLMLPTDEYCAKQLHKAMKGVGTNEDVLVEILCSRPYDEIVKIASAYETMYGNSLESDVQGDTSGPFQRLLVMALQGVRDNYAYDPVKAAEEAQTLYNSGEGQVGTDENAFVEILGHAGQRHAYLIFQEYKKISGKTIEQAMESEMSGEILNGLLAMVKTVHNRPAYFADRLEVAMKGLGTDDDALIRIIVSRCEIDLANIKFEYERIQGRTLLSAVKSEEEAGETSGDYRRALLALIGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9H192</accession>
    <name>E9H192_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_57163</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732583">
        <property type="protein sequence ID" value="EFX74403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74403"/>
    <dbReference type="EnsemblMetazoa" id="EFX74403">
        <property type="protein sequence ID" value="EFX74403"/>
        <property type="gene ID" value="DAPPUDRAFT_57163"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_57163"/>
    <dbReference type="eggNOG" id="KOG1802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_4_3_1"/>
    <dbReference type="InParanoid" id="E9H192"/>
    <dbReference type="OMA" id="HHDSIGY"/>
    <dbReference type="OrthoDB" id="62494at2759"/>
    <dbReference type="PhylomeDB" id="E9H192"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SF1_C_Upf1"/>
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        <property type="entry name" value="SSF52540"/>
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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            <begin position="101"/>
            <end position="251"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF09416"/>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
    <sequence length="1129" mass="125855" checksum="33D32BE32AC084EC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E9H1C9</accession>
    <name>E9H1C9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytoplasmic dynein 2 heavy chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DAPPUDRAFT_324408</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="SSF52540"/>
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    <feature type="coiled-coil region" evidence="16">
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    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
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            <end position="3238"/>
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    </feature>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        <text evidence="1">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
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        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
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        <text evidence="1">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
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        <text evidence="1">Belongs to the eIF-3 subunit D family.</text>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Manak J.R."/>
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    </feature>
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="134" mass="14163" checksum="4F9D6B63E2DB580A" modified="2011-04-05" version="1">MNRNLLNFTGVLIVMVFINFATGATNLNKQRFATQLGSDVSGKVQNSADRGERATPVLQPVVAETSLPLTTRGPVPPRPPPGSIPNLPPIAETPRPTYLLTTSQKPTPGINYPPTNPVIAAAPAIEPETSTDAL</sequence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="26" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="gene ID" value="DAPPUDRAFT_110204"/>
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    <sequence length="238" mass="27517" checksum="9187826C3F8BC597" modified="2011-04-05" version="1">MSVHKSLVLLVFLVIIACRESNALDKGVWRMTPGDEIVEENSVLTLTCTYAYQEGFIDRNFSLRWELPEFLVKNPQLTGVEERFRVTFTTNETHMSSTMSLANATARDTGLYRFFYGDEQIKRYIYVFGIELERVGDPEDPTEGSNVTLICRILFPGIKFPGPPEWEYQINNTAVMQTINITNPPAGDKPIGNYGGYRFVTVFLVFIRRHQDRNRGRKKEARIRWIQTKFLREQTGTV</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX72531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PhylomeDB" id="E9H6M1"/>
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    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
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    </dbReference>
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        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
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    </dbReference>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="352" mass="37884" checksum="4EB6BE562EF1B662" modified="2011-04-05" version="1">MKTSVAALLLLACAVSGQTWGNTGTYSDIARQFQSQDGFGQAKFGYSHPGQSAETHRDARGNQVGSYAYISPEGREIRVNYIADENGYRVDNDYTQETPEVAAARSAHLAAHAAALAAARAASPNQEQWVAPQPKKSVPAPVPVQQTAWTSPPTTRWNTVQAQPGLPQSVQDTPEVAAAKAEFFNTFRVAAARVPKEENVVVPAKKAWTAPVTNWVAPAAQKSWVAPTPTWASAQPVQYGPPQPVQDTPEVQAARNAFFASFREAAARVPQQQNVVVPQQKSWAAPQEKSWAAPQQKSWSGSYQPVVVDQYGLPQQVQETPDVAAARAEFFRSFNAAAAAAAAAQRDTTSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6N0</accession>
    <name>E9H6N0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DAPPUDRAFT_58889</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX72608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="C:neuron projection"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:chemical synaptic transmission"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902476">
        <property type="term" value="P:chloride transmembrane transport"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050877">
        <property type="term" value="P:nervous system process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd19062">
        <property type="entry name" value="LGIC_TM_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Oakley T.H."/>
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                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="72"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="38"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX71683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="126" mass="13176" checksum="E30E1629F2CF146A" modified="2011-04-05" version="1">MKLIVALAFLAVALAAPQGDKKPIEIVSSNSEMNADGSYSFDFESADGTKVSESGNQKQVGPKPEDIGTVSKGSYSFTTPDGVVLTVNWVADENGFQATGDHLPTPPPMPDHVVKMLADLKAAGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9HAP3</accession>
    <name>E9HAP3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_309187</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732612">
        <property type="protein sequence ID" value="EFX71216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71216"/>
    <dbReference type="EnsemblMetazoa" id="EFX71216">
        <property type="protein sequence ID" value="EFX71216"/>
        <property type="gene ID" value="DAPPUDRAFT_309187"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309187"/>
    <dbReference type="eggNOG" id="KOG1066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017110_0_1_1"/>
    <dbReference type="InParanoid" id="E9HAP3"/>
    <dbReference type="OMA" id="GWPLLRM"/>
    <dbReference type="OrthoDB" id="238940at2759"/>
    <dbReference type="PhylomeDB" id="E9HAP3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06594">
        <property type="entry name" value="GH31_glucosidase_YihQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044112">
        <property type="entry name" value="YihQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003238225" evidence="3">
        <location>
            <begin position="23"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX71216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="707" mass="79692" checksum="DD2320EA75233A6F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HBB1</accession>
    <name>E9HBB1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_327638</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732615">
        <property type="protein sequence ID" value="EFX70980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70980">
        <property type="protein sequence ID" value="EFX70980"/>
        <property type="gene ID" value="DAPPUDRAFT_327638"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_327638"/>
    <dbReference type="HOGENOM" id="CLU_433666_0_0_1"/>
    <dbReference type="InParanoid" id="E9HBB1"/>
    <dbReference type="OrthoDB" id="1072875at2759"/>
    <dbReference type="PhylomeDB" id="E9HBB1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="631" mass="72307" checksum="B5A6FF73B87EA470" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HBJ5</accession>
    <name>E9HBJ5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_112285</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732616">
        <property type="protein sequence ID" value="EFX70905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70905">
        <property type="protein sequence ID" value="EFX70905"/>
        <property type="gene ID" value="DAPPUDRAFT_112285"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_112285"/>
    <dbReference type="HOGENOM" id="CLU_514156_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="530" mass="58298" checksum="9EBD175D36F5EDFB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9HBP9</accession>
    <name>E9HBP9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_327766</name>
        <name evidence="1" type="ORF">DAPPUDRAFT_334588</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732879">
        <property type="protein sequence ID" value="EFX64111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX70754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX64111">
        <property type="protein sequence ID" value="EFX64111"/>
        <property type="gene ID" value="DAPPUDRAFT_334588"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70754">
        <property type="protein sequence ID" value="EFX70754"/>
        <property type="gene ID" value="DAPPUDRAFT_327766"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_029165_3_0_1"/>
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        <property type="term" value="F:acid phosphatase activity"/>
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        <property type="term" value="F:inositol phosphate phosphatase activity"/>
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    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
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        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
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        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX64111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="177" mass="21094" checksum="A552445BC1CF372F" modified="2011-04-05" version="1">MWRFDKAWRPKDLSPWWAVFNEDDLQILEYREDLEYFYEDGYGYQINYEQACAPLKKNIFENFSVSQPKGFFYFTHSGTILKVLARIGLYKDKVRPTHSNRLEQMNRAWRTSRIDPFASNIAFVLFKCADDYRVTAFIQERPVRLPGCSDDFCHFREFVDQYGSLVSKCSIDDICRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDQ7</accession>
    <name>E9HDQ7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_257512</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732625">
        <property type="protein sequence ID" value="EFX70068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70068">
        <property type="protein sequence ID" value="EFX70068"/>
        <property type="gene ID" value="DAPPUDRAFT_257512"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_257512"/>
    <dbReference type="HOGENOM" id="CLU_1628697_0_0_1"/>
    <dbReference type="OrthoDB" id="1802880at2759"/>
    <dbReference type="PhylomeDB" id="E9HDQ7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="163" mass="18213" checksum="EFB39DAFBBD64B3F" modified="2011-04-05" version="1">MLAGNLDGLVSFSFQFTPAFTFEKAIGLSMIVFGVLLKFLADPLRTFLVQKLNLGNITIDVLANMKYVIDQVKTNFDYQSPGGGTRGDTQVLHTVFDCRNDNAYNAFIRSSTDWKPQLDVVHDILNVINHQAETSEVQTIVDRLVMLEAEGATATEEDFKFMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9HFS2</accession>
    <name>E9HFS2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_231695</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 10">Mitochondrion inner membrane</location>
            <topology evidence="3 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732637">
        <property type="protein sequence ID" value="EFX69420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69420"/>
    <dbReference type="EnsemblMetazoa" id="EFX69420">
        <property type="protein sequence ID" value="EFX69420"/>
        <property type="gene ID" value="DAPPUDRAFT_231695"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_231695"/>
    <dbReference type="eggNOG" id="KOG4604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068905_2_0_1"/>
    <dbReference type="InParanoid" id="E9HFS2"/>
    <dbReference type="OMA" id="RAWPIIM"/>
    <dbReference type="OrthoDB" id="1625075at2759"/>
    <dbReference type="PhylomeDB" id="E9HFS2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="PTHR21304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX69420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="96" mass="10050" checksum="76CCABA0502ADC14" modified="2011-04-05" version="1">MAPSANSEDALAKTFDSCVADTIIKIGGGMATGVLFSLFLFKRKSWPVVFGVGVGAGMGASNCQYKLNVPFMVRADQIKVMGTTANVKDSSSEIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9HFW8</accession>
    <name>E9HFW8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_113732</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732642">
        <property type="protein sequence ID" value="EFX69115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69115"/>
    <dbReference type="EnsemblMetazoa" id="EFX69115">
        <property type="protein sequence ID" value="EFX69115"/>
        <property type="gene ID" value="DAPPUDRAFT_62606"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_62606"/>
    <dbReference type="eggNOG" id="KOG3024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046061_2_0_1"/>
    <dbReference type="InParanoid" id="E9HGN1"/>
    <dbReference type="OMA" id="QIGEMYF"/>
    <dbReference type="OrthoDB" id="1030907at2759"/>
    <dbReference type="PhylomeDB" id="E9HGN1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="PTHR12875"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX69115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="321" mass="36979" checksum="46789E566BD28240" modified="2011-04-05" version="1">MAGIVRAGPGAERVLQKLRKSIEDGNYYEAHQMYRTLYFRYMGQEKYESLLKLLYDGSLLLFQHQQHSSGADLAKLYVEVLQKAKMNVRKDIINNLADMMSKIPAAAPERQAFLMSALSWSQSENPESKKFEGHPQLHQMVANIYWRETNYHMARYHFIRSDDMQNLGSMLVEIQVDLGYPSEIDLFVTQAVLQILCIRNLSFANSLFDNYLECHPLLDNEPPFKYPLLNFTWMLLLTIQSTKISSYAILCEYYQPSLKRDPSYKDYLDRIGQIYFGLPPPRGMPNQGMFGNLIQSLIGSLDDSDSEDNTARSNLHASDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGR7</accession>
    <name>E9HGR7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_231717</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732643">
        <property type="protein sequence ID" value="EFX69073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69073"/>
    <dbReference type="EnsemblMetazoa" id="EFX69073">
        <property type="protein sequence ID" value="EFX69073"/>
        <property type="gene ID" value="DAPPUDRAFT_231717"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_231717"/>
    <dbReference type="eggNOG" id="KOG0176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_2_1"/>
    <dbReference type="InParanoid" id="E9HGR7"/>
    <dbReference type="OMA" id="FQVEYAR"/>
    <dbReference type="OrthoDB" id="1222564at2759"/>
    <dbReference type="PhylomeDB" id="E9HGR7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX69073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="242" mass="26500" checksum="26CFC509DD164B9C" modified="2011-04-05" version="1">MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVVLAVEKRITSPLMEPTTIEKIVEIDKHIGCAVSGLMADSRTMVDRARVEAQNHWFTYDEKMSVESVAQAVSNLAIQFGDSDDDGNAMSRPFGVAILFAGIDEKGPQLFHMDPSGTYVQYDAKAIGSGSEGAQQSLQEAYNKSMTLKSAMKAALTILKQVMEEKLSSTNVEVAAVTPDQPFHMYSKEQVEDVIKEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJL5</accession>
    <name>E9HJL5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_218385</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lin-52 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732663">
        <property type="protein sequence ID" value="EFX68039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68039"/>
    <dbReference type="EnsemblMetazoa" id="EFX68039">
        <property type="protein sequence ID" value="EFX68039"/>
        <property type="gene ID" value="DAPPUDRAFT_218385"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_218385"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:DRM complex"/>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="DREAM_LIN52"/>
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        <property type="entry name" value="PTHR31489"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LIN52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX68039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="122" mass="14015" checksum="F45B003DBE3EBEA1" modified="2011-04-05" version="1">MSKMKAKKEPSSDLEQSLLSTEKLDRASPDIWPERNYPGIEYVIEPPRSPEMPALPQSIIPQELDKHDYTLVGRYSKLTAQELIAEVKQLQNLAYQLGLEEAKEMTRGKYLNILSSNKKRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKN8</accession>
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        <recommendedName>
            <fullName evidence="2">Aminotran_1_2 domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732670">
        <property type="protein sequence ID" value="EFX67688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67688"/>
    <dbReference type="EnsemblMetazoa" id="EFX67688">
        <property type="protein sequence ID" value="EFX67688"/>
        <property type="gene ID" value="DAPPUDRAFT_301811"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG1358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_0_1_1"/>
    <dbReference type="InParanoid" id="E9HKN8"/>
    <dbReference type="OMA" id="RNTPTFA"/>
    <dbReference type="OrthoDB" id="438936at2759"/>
    <dbReference type="PhylomeDB" id="E9HKN8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
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    </dbReference>
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        <property type="term" value="P:ceramide biosynthetic process"/>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="94"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="468" mass="52318" checksum="8EAB06C5F586CDF8" modified="2011-04-05" version="1">MVVQWDLYEMYLALLQAPLYHLIIEGLLMVWVAWLLLRKPKIRKPKLTEKEQEELISEWQPEPLVPDTPEDHPALDPFVVEGKVGKYVCVNGRDCLNLATHNYLGLVEDKTMEDSAVECIKKYGVGSCGPRGFYGTVDVHLNLETRLAQFMELEEALIYSYGFSTIASAIPAYAKRGDVIFADEGVNFAVQKGLEASRSDVRFFKHNDMKDLERLLEAQRSKELKNPKNGKNVRKFLVIEGVYMNSGDICPLPEIVELKSKYKVRLFVDESISFGTLGRHGKGITEYYGIPTDHIDLIMGSLEYAIPSVGGFCVGTSYVVDHQRLSGLGYCFSASLPPMLAAAAITAIDSMEKNPDMFLDLNNVCRQLHSALSSLHQLRLGGHKDAPVKHLRLAKSTGCNNHDGQLLRQIANESMKRGLAVIVASYLDQSERFLPQPSLRLAANRLLTENDLDKVIKILEDSCTAILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HL54</accession>
    <name>E9HL54_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_261516</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX67526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67526">
        <property type="protein sequence ID" value="EFX67526"/>
        <property type="gene ID" value="DAPPUDRAFT_261516"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_261516"/>
    <dbReference type="HOGENOM" id="CLU_085173_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HL54"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="198" mass="23050" checksum="7315AC42DA102BDE" modified="2011-04-05" version="1">MATRFPLEMIEEEPEEEELEEDEPEEWQTTADPAVIKHRRISAKSAHTKSLNQALLATRAGEDVEKVKLLRAIIVREYEALKEIHTRYMELAKLNQEDGDKEYKWAYEVTEKQRKALKDVQKYLNPHLPKPEGSVRSSASSRSSTREKLQEAERLQKETELKIQQQRAEATERAAEEELMHQLETARKAEENVVWPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLL3</accession>
    <name>E9HLL3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_261750</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732679">
        <property type="protein sequence ID" value="EFX67373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67373">
        <property type="protein sequence ID" value="EFX67373"/>
        <property type="gene ID" value="DAPPUDRAFT_261750"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_261750"/>
    <dbReference type="HOGENOM" id="CLU_625944_0_0_1"/>
    <dbReference type="OrthoDB" id="31942at2759"/>
    <dbReference type="PhylomeDB" id="E9HLL3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="438" mass="50410" checksum="4E95843115231749" modified="2011-04-05" version="1">MASNMSENHLKDVSHVPKFDGSNFRECSYELRMILQQLGLLSILDARVGHPIPTESSATPSDDSDSDTTSERLLYVSKIDTKQKNKLDNIIQTLGTSLHEAFRPSQVQKLTGNLTNLKSESPFGNFNLDTSSSSAGCSDVCILGNVKKEYEPPGDVPDAAYGEALIQFREHIHRRVVNNESGQSWKSRSIEEFSGYIEEVWKCIGSANFNFNFATVVERITFDKLESEYKKTEQKLAEAYLESFASIKRNMIEEKGKTIRSAPVDEMSNAIRLASFEAKLRDQVMPTEQRLDVEVKEILKRKGREKWNLQFEELWKMNKLGQERNWNFSLKTSFNTLFNYEHHVESYKKKMREEINELFKSTNLNDSEWTEKDKNNKFVEMFARILLEVQQHFPPKDIPEEIKKVYLNSNVIKTRQIEMMVVAGDGQSHVDARTCDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPF8</accession>
    <name>E9HPF8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_263269</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732705">
        <property type="protein sequence ID" value="EFX66379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66379">
        <property type="protein sequence ID" value="EFX66379"/>
        <property type="gene ID" value="DAPPUDRAFT_263269"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_263269"/>
    <dbReference type="eggNOG" id="ENOG502TMQ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1449097_0_0_1"/>
    <dbReference type="InParanoid" id="E9HPF8"/>
    <dbReference type="OrthoDB" id="222689at2759"/>
    <dbReference type="PhylomeDB" id="E9HPF8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="2">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX66379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="187" mass="20774" checksum="CD34790825C4871B" modified="2011-04-05" version="1">MAPNSTSATLVQLDKNRRDYVSDIRQRFVKDYLLQLDNFHSKGKATRKILVGEVVVIHDELTKRLMWKTGVVKELIPSRDGLVRSVTLKTPNGNLINRAIQCLHPLELREDLDEDVDAVDGDPEPEEDPTPVDPAPIIPVAIEAVGDPVDGEVEPHRMGSGGEYVGNRIDAQQRRLGSAGKLHCRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPK4</accession>
    <name>E9HPK4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_302751</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732708">
        <property type="protein sequence ID" value="EFX66330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66330">
        <property type="protein sequence ID" value="EFX66330"/>
        <property type="gene ID" value="DAPPUDRAFT_302751"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302751"/>
    <dbReference type="HOGENOM" id="CLU_065450_1_0_1"/>
    <dbReference type="InParanoid" id="E9HPK4"/>
    <dbReference type="PhylomeDB" id="E9HPK4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012926334" evidence="2">
        <location>
            <begin position="16"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX66330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="169" mass="18833" checksum="E7ABFFBD24D40FA2" modified="2011-04-05" version="1">MKLFVIAAILAVAAAAPSGYKTEEKYEKDYKYPEITVVSQSDERNLDGSSQWSYALSDYTTRDESQVQKKFTVTTVDDYGKEYTKEVMGNTNKGSSYWVSPEGEKFTLTWVADDAGFQPKGDHLPVAPVHVYELPVAPVHVYELPVAPVHEYELPVAPALPYKRTGAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9HQS9</accession>
    <name>E9HQS9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_332720</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732724">
        <property type="protein sequence ID" value="EFX65909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65909">
        <property type="protein sequence ID" value="EFX65909"/>
        <property type="gene ID" value="DAPPUDRAFT_332720"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_332720"/>
    <dbReference type="eggNOG" id="ENOG502TB6Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_929291_0_0_1"/>
    <dbReference type="InParanoid" id="E9HQS9"/>
    <dbReference type="OrthoDB" id="1189265at2759"/>
    <dbReference type="PhylomeDB" id="E9HQS9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="SSF57756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
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    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
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    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
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    </dbReference>
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        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="SSF57756"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
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        <location>
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        <location>
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        </location>
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    </evidence>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Manak J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
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                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
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                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX63053.1"/>
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        <property type="gene ID" value="DAPPUDRAFT_336001"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2415542_0_0_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="EFX63053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="92" mass="10251" checksum="59B4A520D49FD634" modified="2011-04-05" version="1">MKIVSTKRYRALNWEAIAENRVVGMGPGEKVDDFMIFSSICKVTQSVSGSQLAPIQKMVEQIPELAELTNLDISLVARNVEWTLAQQQTQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZN5</accession>
    <name>E9HZN5_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DAPPUDRAFT_119852</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX62795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62795">
        <property type="protein sequence ID" value="EFX62795"/>
        <property type="gene ID" value="DAPPUDRAFT_119852"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_119852"/>
    <dbReference type="HOGENOM" id="CLU_1200883_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX62795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="231" mass="24772" checksum="2B41BCF99BE44B50" modified="2011-04-05" version="1">MSYSSFGRAPNSTLDGPDSKLGGFNPRLSLKQAVKFWSQDDANIILSSVCRTLNSSSDRPVGRALNSSSDGPGSNLYGFNPRLALKQAAKCFSHTKENIFHMSISSVGRALNSSSDGPGSKLGGFNTRVALKQAFKCWSHTKGNFVHMSLSSVDRALNSSSDGTDSNLGGFNPRLALKQAAKCWSHTDENIFHMSLSSVGRVRNSSSDGPGSNLGGFNPWLALKQAAKCWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9I0U7</accession>
    <name>E9I0U7_DAPPU</name>
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        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
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    <organism evidence="4">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733632">
        <property type="protein sequence ID" value="EFX62381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62381">
        <property type="protein sequence ID" value="EFX62381"/>
        <property type="gene ID" value="DAPPUDRAFT_337037"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_337037"/>
    <dbReference type="HOGENOM" id="CLU_535596_0_0_1"/>
    <dbReference type="InParanoid" id="E9I0U7"/>
    <dbReference type="OrthoDB" id="1535084at2759"/>
    <dbReference type="PhylomeDB" id="E9I0U7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="509" mass="57470" checksum="1A897B44CD3BF7BE" modified="2011-04-05" version="1">MFMNKSISLKTVDLFARLREQRNSESSIMTESLVPPVKKPKLSFLRKIGIFKPPATLKKPSGWARAKAAICNSSSLLAKTLSLFQRKRRTSSRIQDISDSNVPEDLIEVENQDIVLPTYGNGSIASGMQNFGNGDIPGNRNTSELRQNATNATRLVHQCSPVAFATPDRSSTPIAPVASSVRFSTPTSSPHTATHLSSSVLIHPNVATAADHLYGESEVLVIKQPRSSVVNENIITSGFRLKNILERGYPKNAQPTKDEETTRSLIFRRKFLAGLDLQTKYKVRYKHFKVYEDLVRETDKYDRRLEAEKEEFRKRKFVNDMTSSLSQSASHLIWQAIETQNEKINAITSMSRFNTDPPDTAIELIPNEDLTNRIMEILHHLIAYQQLPFSAHQHLYTFNSPTLNVQPNEANHFIFPSSDPLIQHQFIHQQTQSLSTPQIKCYFCGNAGHRQRECREQARVAKKMFNSKGERGRLMPYYNYGALGHQPSSCSNKEPITCGVAEGYMEITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2X7</accession>
    <name>E9I2X7_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="3">
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        <name type="common">Water flea</name>
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            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734280">
        <property type="protein sequence ID" value="EFX61653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61653">
        <property type="protein sequence ID" value="EFX61653"/>
        <property type="gene ID" value="DAPPUDRAFT_338565"/>
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        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
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            <begin position="50"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="EFX61653.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="87" mass="9143" checksum="00CC000E26E26763" modified="2011-04-05" version="1">MPSKTVGRRGSTSEALRPGADGDGKLSSESLGAGLTFSSGGNDEDKKNELDGEDERDDEDPVAPESKDDHDDDDSSFDDEPPSVLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
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</entry>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Wolf Y.I."/>
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                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="64" mass="7137" checksum="DE859C7C51BD3BD0" modified="2011-04-05" version="1">MNEVNLKIISRYILMDSDIPKSGCIAIEKKVRSTQPVPPTLSPRSIDPQTGGSEWKLVVPMSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="221" mass="23809" checksum="47F07B5F0248EC86" modified="2011-04-05" version="1" fragment="single">MDFNLQKLWTPSDGVISETLDLASKILNPPLLPKPKDGISGLPIQTKTVPESSINCSGQSHIIPLPVDGPITHYIVVQDNIAVPNKPTLTVDVGLNVNGTLSNLVTPTVQNDRMDVSSSASCSFDHSYVLVPPRTPTSLEESAAASSTLCNSESATSQEAQENAGPNESDHNYVIRSSSIPTVNEEESLHLDMAGYHNFINGVATPTAEWTWSFNERNNNL</sequence>
</entry>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Pritham E.J."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="252" mass="28873" checksum="83A7109BC37218BB" modified="2011-04-05" version="1">MFFIPGSQTRKRFYKKVSTVQSNKDFEIILDNRKLKTPAGSVFRVSSEPLALAVANEWDAQEEKILVSSMHLTSLVNTILDNPNKLRKQDIVCHILTYLDNDTLLCREEGNSDWSSEQTKEWDPLVDWFNQRYGTNVESSSAITGPCLPIEARDVLQKHLHSYDFWTLNGLMFAVESVKSLILALACVDRHLTVEESVRLATLETNFQTRQWGRVEWAHDVDNFNVQSRFAASILFVHLTSSSSSIENKFKK</sequence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX89998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89998">
        <property type="protein sequence ID" value="EFX89998"/>
        <property type="gene ID" value="DAPPUDRAFT_232278"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_232278"/>
    <dbReference type="HOGENOM" id="CLU_1090926_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89998.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="255" mass="28971" checksum="BEFF5C67C681E865" modified="2011-04-05" version="1">MSVIPIPIPSNVNLQKEKGVCMAFTFGGHGDHYRLMFTTPPSHECYMVIYAALNYYTKASKCYTINVQPICKQGSVYYTTIDPDCYAAPNRYIEAPKYYTIEDYYDVVLLLGVVLWMAGFTMSVPMSPGYGGFQNTRLLPYYLTTSTYASPTYYTDACKYYTSKAPRVLHEYLRSSELLNGSITLLPSYINKTSEYYTEDLKYTSKVNCGVVLLLRMVSLKAGLIIGVLRYLDMAYYNTKAPVPEYYTTHTAPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9FTN2</accession>
    <name>E9FTN2_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_303199</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX89391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89391"/>
    <dbReference type="EnsemblMetazoa" id="EFX89391">
        <property type="protein sequence ID" value="EFX89391"/>
        <property type="gene ID" value="DAPPUDRAFT_303199"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303199"/>
    <dbReference type="eggNOG" id="KOG0443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002568_3_1_1"/>
    <dbReference type="InParanoid" id="E9FTN2"/>
    <dbReference type="OMA" id="GGRQKHI"/>
    <dbReference type="OrthoDB" id="1376537at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
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    </dbReference>
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        <property type="term" value="P:actin filament severing"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:actin polymerization or depolymerization"/>
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    </dbReference>
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        <property type="term" value="P:barbed-end actin filament capping"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
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    </dbReference>
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        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="6"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="28"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="143"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="267"/>
            <end position="340"/>
        </location>
    </feature>
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        <location>
            <begin position="417"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="546"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="651"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX89391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="738" mass="82593" checksum="D25B80F45C2D5CCC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9FV00</accession>
    <name>E9FV00_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_41567</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 9">Preautophagosomal structure membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ATG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88810"/>
    <dbReference type="EnsemblMetazoa" id="EFX88810">
        <property type="protein sequence ID" value="EFX88810"/>
        <property type="gene ID" value="DAPPUDRAFT_41567"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_41567"/>
    <dbReference type="eggNOG" id="KOG2173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006200_2_2_1"/>
    <dbReference type="InParanoid" id="E9FV00"/>
    <dbReference type="OMA" id="PEFGNRY"/>
    <dbReference type="OrthoDB" id="712239at2759"/>
    <dbReference type="PhylomeDB" id="E9FV00"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044805">
        <property type="term" value="P:late nucleophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="PTHR13038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX88810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="584" mass="67969" checksum="20C9AB8C590DF6C9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9FW53</accession>
    <name>E9FW53_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_220880</name>
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    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the geminin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88663">
        <property type="protein sequence ID" value="EFX88663"/>
        <property type="gene ID" value="DAPPUDRAFT_220880"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_220880"/>
    <dbReference type="HOGENOM" id="CLU_1344487_0_0_1"/>
    <dbReference type="InParanoid" id="E9FW53"/>
    <dbReference type="OMA" id="MCETNIP"/>
    <dbReference type="OrthoDB" id="1750594at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045786">
        <property type="term" value="P:negative regulation of cell cycle"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008156">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF07412">
        <property type="entry name" value="Geminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="85"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX88663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="204" mass="22338" checksum="03E5CB7B05F9445C" modified="2011-04-05" version="1">MSKHQSSLAFKENSLPKGIPPSTLEDSADMDEVFSAQRVTLQTLQPSAKTKGLVGSHGQIIHHGKDLKSKQKTQSIQGKIQVFEDKTSNTGPKKNMVEDRGVQTDPIELEESKSKTAENDIDVEYYSTMAERRRVALSEALEENEHLHLEVDSLKTEINALKAENSVLKPLAEEAEYLAGVIKGLLGSEEEETTEGATASTSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9FWF1</accession>
    <name>E9FWF1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein DpuGr4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DpuGr4</name>
        <name evidence="5" type="ORF">DAPPUDRAFT_346911</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX87880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87880">
        <property type="protein sequence ID" value="EFX87880"/>
        <property type="gene ID" value="DAPPUDRAFT_346911"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_346911"/>
    <dbReference type="eggNOG" id="ENOG502SVZ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058520_0_0_1"/>
    <dbReference type="InParanoid" id="E9FWF1"/>
    <dbReference type="OrthoDB" id="1715714at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="PTHR21143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX87880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="396" mass="45057" checksum="26C65C41361996AF" modified="2011-04-05" version="1">MLVPTRTVSEEAVEKGWLWSVQPLVTWAKWLGIDLSDLSSGGRKKVSRWFVLYSVFVLLISVSLQLPCLSYIINNHKEISVTFTIENSYNSDTFSWNTAMDYVNFAVHSLATHVIFLSVFRARWNLLGETFQNLESFLKFSFFDRIRKASILGLVWIILLHTTLLATNLYHHSEYGSSFLILFCSLVSVFSQVYPITAIVLFSAVCYASSNAHQSIRMELNLLKNTTTDGNYYNRLSTLKRRHALVCETVDHINHCFGFFMGISLSFHFVSMITASFYLFGTDKEPGSVLEIGFACSQICNLSLICYPADLIRLKADSVFRKLIRMQLEMEEPLKSLTNAFAEQTSLFFPQINAAGFYPISRKIIPQIVGTTLSYFFILYQFQSAERSDTSVNAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9FX04</accession>
    <name>E9FX04_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_311475</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88344"/>
    <dbReference type="EnsemblMetazoa" id="EFX88344">
        <property type="protein sequence ID" value="EFX88344"/>
        <property type="gene ID" value="DAPPUDRAFT_311475"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_311475"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_1_1"/>
    <dbReference type="InParanoid" id="E9FX04"/>
    <dbReference type="OMA" id="IPERFLC"/>
    <dbReference type="OrthoDB" id="786853at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006697">
        <property type="term" value="P:ecdysone biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX88344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="340" mass="39262" checksum="0BE00EFED8884E2F" modified="2011-04-05" version="1">MSKLALDILSETSMGRKTWSEEETINYVQGLEGLEHVYTQRSFHQPWLRSDFIFKLSPLYRLEKRCISNTRSLIDKVIQNRHEQQKKNGQSLVFNNNEKEEDEYNRPKKRLAFLDLLFQAAEANPDLNDEAIRNEIFLFMSAGLDTTSLTLIWFLYLIAKHPEQQKLVTQELDLIFSDDSDRPMTAQDLPLLKYLECCIKETLRLYPSLPLISRHLTEDVQAGRYTLPKGLTVILNIYSAHRNPEVYPDPDAFKPERFFPENSVGRHPYAFIPFSAGVRICIGYKYAMMELKVSLANLLRRLRFSVSDPSAPLEIPSMQLTAKPKSGQCNLIVSKRVVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXH3</accession>
    <name>E9FXH3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_96294</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88269">
        <property type="protein sequence ID" value="EFX88269"/>
        <property type="gene ID" value="DAPPUDRAFT_96294"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_96294"/>
    <dbReference type="HOGENOM" id="CLU_1462757_0_0_1"/>
    <dbReference type="OrthoDB" id="1745567at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="196" mass="21554" checksum="AEF14EFACAC0E730" modified="2011-04-05" version="1">MAISYPRLSPRGLRGLSIFNIILWVFSSVLTIAIVIRYSNFGQGPDYNNIGGLDYIFAGIWAGWFYGVAGIVGIFGSYERKRVQLLTVVTFNVLSLVGASISGCIAGIIGFYIIRKFNEICYPALLLAYDNSDEDCTVWMSLEFALLAFSGIAFFVNLTCLIVTLVAICGPKKSTGLVRMEVGNPAYDFKQRRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXV3</accession>
    <name>E9FXV3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_311770</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88168">
        <property type="protein sequence ID" value="EFX88168"/>
        <property type="gene ID" value="DAPPUDRAFT_311770"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_311770"/>
    <dbReference type="eggNOG" id="KOG1418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029888_0_0_1"/>
    <dbReference type="InParanoid" id="E9FXV3"/>
    <dbReference type="OMA" id="FAYITMA"/>
    <dbReference type="OrthoDB" id="1211599at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071805">
        <property type="term" value="P:potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="PTHR11003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="10">
        <location>
            <begin position="65"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="10">
        <location>
            <begin position="157"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX88168.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="486" mass="54953" checksum="2BD9F6BE5AB331BE" modified="2011-04-05" version="1">MTINTSFCQDLMNSVKYSASLSNRGGANYENYSFEMWFEVVKESCNNLTVKLENVTDVNGTGDVAWEFSSALFLCMNILTTIGYGNFSPKSDWGKIFCIFYGFVGIPICVVFLASTSDYFSNMFLYLYERRQKNQRNDDKRHSIFIAAIFFLIPGLAVFIFFPSAIFVFIEGWSYLDATYFSFLTLTSVGFGDIVAAQQTNCKLLWLYRISWIIWVTLGIAYWAIVINFITKALKSKKVREKWEKTSHALSAQAKEVRRVVRSFSNNTLQLSHSGQNSSNEFIALKSKTAFDFAHHFTDSMGKALTNPERKRSSLTDFVTAFQSGSGLVLQQQQSVVNYNPDVTESIPRWELGERQSEQFPVSAKDIIDAYTQNDGSYPWLSFGNAQTGSANVDDNVSLPSVYLSANPSRKTSETKNDFPSRWYDDDASIRSTYLSLNPSRKTSETNNENSNTPQTLTENPPLRNLLIEALMILNEAETNGTVLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYS1</accession>
    <name>E9FYS1_DAPPU</name>
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        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="141" mass="15776" checksum="D74063DD9FCFD3E8" modified="2011-04-05" version="1" fragment="single">MVDLDRKLTPSPPLPAAAAGQKPEQQQDHYCLRWTNHGSHVLGVFAQLLRDESLVDVTLAAEGRSLRAHKMVLSACSSFFRTLFVSHSDQRHPIVILKDTKFTELESLLQFMYKGEVSVEYGQLATLLKTAENLRVKGLAD</sequence>
</entry>
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        </lineage>
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    <reference evidence="1 2" key="1">
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_312548"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312548"/>
    <dbReference type="HOGENOM" id="CLU_2225862_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX87045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="106" mass="11928" checksum="EC671C11E285586E" modified="2011-04-05" version="1">MESCFSLRTGYAIKYLTDSEDLKKRDIEQLPIRPNGRDLRTWLNHSETTIYSISSGTKGLQNAETEIKYLFVSTGILAQGALREDKQPKIANDGLGVDVTFDILFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9G005</accession>
    <name>E9G005_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
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    </protein>
    <gene>
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    </gene>
    <organism evidence="4">
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        <lineage>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87142"/>
    <dbReference type="EnsemblMetazoa" id="EFX87142">
        <property type="protein sequence ID" value="EFX87142"/>
        <property type="gene ID" value="DAPPUDRAFT_312702"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312702"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_7_4_1"/>
    <dbReference type="InParanoid" id="E9G005"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="33"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX87142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="247" mass="27438" checksum="C426F2ECB70E1387" modified="2011-04-05" version="1">MAQYRRLICIFLKMFKAYLKSYYASSPGFYFGCGAYKVEVSLKVYTIRPMDSGAKLITVTKSGIKPNPQFARNGVANYNFDIALIKLSAELPTSDYYLIGKVYTSTYQQYYNYNGPVTAVGWGRNSSANDASSTLQKVDFKIGTKDECSGYWGSSKRDYDHVYQMCGVTPGKSVCKGDSGGPIVRYSSAHQTYLQVGISSFVPSSNGQAQCEKGFAVFTRVSVHRDWIDRNSCLLNDGGFCPTWLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9G151</accession>
    <name>E9G151_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ULP_PROTEASE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_307887</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86698"/>
    <dbReference type="EnsemblMetazoa" id="EFX86698">
        <property type="protein sequence ID" value="EFX86698"/>
        <property type="gene ID" value="DAPPUDRAFT_307887"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307887"/>
    <dbReference type="eggNOG" id="KOG0778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024324_2_2_1"/>
    <dbReference type="InParanoid" id="E9G151"/>
    <dbReference type="OMA" id="HNNSHWT"/>
    <dbReference type="OrthoDB" id="1480705at2759"/>
    <dbReference type="PhylomeDB" id="E9G151"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ULP_PROTEASE" evidence="2">
        <location>
            <begin position="24"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX86698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="218" mass="25353" checksum="8C569F9B05B716EA" modified="2011-04-05" version="1">MHNVIEKAWGGYSENEVLCDAFSLTITRRDVKTLSGLNWLNDQVINFYLTLVMERSSSGDWPKAYAFNTFFYPKLMSSGHSGLKRWTRKVDLFQQDIILVPVHLGLHWCLATVCPKEQAIRYYDSMGGRNQDCLNGLKRYMEAESMDKKKTSLDTSNWTLECVEDIPQQMNGSDCGMFTCKYAEYLSRKAKITFAQKDMPYFRKRMVYEIITQKLINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9G281</accession>
    <name>E9G281_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_299672</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732530">
        <property type="protein sequence ID" value="EFX86348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86348"/>
    <dbReference type="EnsemblMetazoa" id="EFX86348">
        <property type="protein sequence ID" value="EFX86348"/>
        <property type="gene ID" value="DAPPUDRAFT_299672"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299672"/>
    <dbReference type="eggNOG" id="KOG4254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019327_0_0_1"/>
    <dbReference type="InParanoid" id="E9G281"/>
    <dbReference type="OMA" id="GMQGAWG"/>
    <dbReference type="OrthoDB" id="392025at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX86348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="546" mass="59284" checksum="096D73456024949A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G2C6</accession>
    <name>E9G2C6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_236949</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732530">
        <property type="protein sequence ID" value="EFX86226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86226">
        <property type="protein sequence ID" value="EFX86226"/>
        <property type="gene ID" value="DAPPUDRAFT_236949"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_236949"/>
    <dbReference type="HOGENOM" id="CLU_1788813_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX86226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="145" mass="16155" checksum="D7871A6CB7CE2B03" modified="2011-04-05" version="1">MPDSDIDYPQKLSGSNTCTTINQRAAGRRVLFFSALSTATYDSTPTGAFHCCCDGERSAAAAAQYYRLYMFESQKAESILRGLGLLSQRGPGPRSLILTNPRYVKRFDGHRPKSFESAAEKEVKKVEEKKIAFCGSIDRYTLVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9G2P3</accession>
    <name>E9G2P3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_222058</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
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            <taxon>Cladocera</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBQ-conjugat_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="71"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX85571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="217" mass="23437" checksum="63565D715E51A4EB" modified="2011-04-05" version="1">MSTSGAGPSSSNRVQHQQGSNSSSGQTEANGNTTPSPPPQSSTNPAATATPPVKEAKEAKPNPKMSKALSTSAKRIQKELAEITLDPPPNCSAGPKGDNLYEWVSTILGPPGSVYEGGVFFLDIHFSPEYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYLQNREEHDRVARLWTKRYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9G4W1</accession>
    <name>E9G4W1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_314177</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85368">
        <property type="protein sequence ID" value="EFX85368"/>
        <property type="gene ID" value="DAPPUDRAFT_314177"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_314177"/>
    <dbReference type="HOGENOM" id="CLU_1837083_0_0_1"/>
    <dbReference type="OrthoDB" id="1053004at2759"/>
    <dbReference type="PhylomeDB" id="E9G4W1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX85368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="140" mass="16070" checksum="5894A7354AC2F95D" modified="2011-04-05" version="1">MRYGDMQVYLCWTCVQQQSQYRHMAPKIVSILTNIMKPFLSGKTTSSPRSKSSKNLLKNGKRLFWNTSILKSYLLATAEINMGGKVPKSYYLRYKTDTTNKKSLSIPKDSKKQLEIKVKETGAMLKYNSLSALKDIPYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9G571</accession>
    <name>E9G571_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_238096</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85423">
        <property type="protein sequence ID" value="EFX85423"/>
        <property type="gene ID" value="DAPPUDRAFT_238096"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238096"/>
    <dbReference type="HOGENOM" id="CLU_550141_0_0_1"/>
    <dbReference type="OrthoDB" id="1690215at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX85423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="496" mass="53058" checksum="1239B440B663F327" modified="2011-04-05" version="1">MLIDSERCGLIESLENPVPSLSVVYYFVGTTITDADSYHVSPVGWKSMQESDRVNYCPNGLQSLHHIRSGVAGGTAGGSRANWDQQQQGQFRPFGSDKPCSVLVNETMNQNDAQVIVERILITADTMGNSFSSSSFTGGSNQQLDTWAAQACGQMQNIVGYLKSACQFSLSASSISSTGSTSSTELAAQKKLGAMNAAKDYLCSNNQVNLKEMAMNNGAQCARKTDLNEFGCNIQQGAQPTFVQMLPSPNRQTLKYGTSIILSMNSYNGDDCKYIADVTNCILDKYTRGTDFCSSRASTHFGRIFDVMLQGVQCKTGGYSTFNTFDSSNSFNNNPTFNRFPSGSSGGSSNGGVNFPNNNQNNFGSNSGSFPQNFPQGSASNFGGQGTNNFGSNSGSNWPQNQNDFGMNSGNNWPQQNPNSFGVNSGSNWPQQNPSGMGQSSGSFGQSSNNFGQSSGFGSSGTIPPYNRRPYNNSGSAIQTTMAMVVTTIFTACLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E9G628</accession>
    <name>E9G628_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_209250</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX85068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85068"/>
    <dbReference type="EnsemblMetazoa" id="EFX85068">
        <property type="protein sequence ID" value="EFX85068"/>
        <property type="gene ID" value="DAPPUDRAFT_209250"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_209250"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010982_0_1_1"/>
    <dbReference type="InParanoid" id="E9G628"/>
    <dbReference type="OMA" id="NFFKYKS"/>
    <dbReference type="OrthoDB" id="704215at2759"/>
    <dbReference type="PhylomeDB" id="E9G628"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2_III"/>
    </dbReference>
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        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
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        <property type="entry name" value="Calpain_domain_III"/>
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        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
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        </location>
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        <location>
            <position position="289"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX85068.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="708" mass="81191" checksum="38183BDA2122496B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6X8</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Daphnia pulex</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="266752at2759"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX84736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9G755</accession>
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    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Branchiopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
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    <comment type="similarity">
        <text evidence="1 2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_004790_3_0_1"/>
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    <dbReference type="OMA" id="YGHELET"/>
    <dbReference type="OrthoDB" id="365203at2759"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="350"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="647"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="676"/>
            <end position="694"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="703"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="703"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="723"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX84704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="747" mass="82993" checksum="1A37570CB570B834" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9G781</accession>
    <name>E9G781_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaminyl-peptide cyclotransferase</fullName>
            <ecNumber evidence="3">2.3.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_314716</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23652"/>
            <dbReference type="Rhea" id="RHEA-COMP:11736"/>
            <dbReference type="Rhea" id="RHEA-COMP:11846"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="ChEBI" id="CHEBI:87215"/>
            <dbReference type="EC" id="2.3.2.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaminyl-peptide cyclotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84420"/>
    <dbReference type="EnsemblMetazoa" id="EFX84420">
        <property type="protein sequence ID" value="EFX84420"/>
        <property type="gene ID" value="DAPPUDRAFT_314716"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_314716"/>
    <dbReference type="eggNOG" id="KOG3946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045003_1_0_1"/>
    <dbReference type="InParanoid" id="E9G781"/>
    <dbReference type="OMA" id="AFTAEWM"/>
    <dbReference type="OrthoDB" id="1257754at2759"/>
    <dbReference type="PhylomeDB" id="E9G781"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017186">
        <property type="term" value="P:peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="PTHR12283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236720" description="Glutaminyl-peptide cyclotransferase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="7">
        <location>
            <begin position="114"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX84420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="347" mass="39689" checksum="AEA6A21E5AEB01DF" modified="2011-04-05" version="1">MLVHTNKMISLKGLLFLISLFNQSQSQAWFHAKSSHQANLLNLDQLKYVSGLSDMQRFDVTVDPILVPRVVGTPNHARVRQYIMDQMQSLGWDVGTDKFTADTPRPHGKKTFENIITTLDSNAQRRLVLACHYDSKYTRDGNFIGATDSAVPCAMMITLAKDLAPKLDQLKKSNSQVTLQFIFFDGEEAFKDWNSRDSIYGARNLARKWESTSYPAQNRDGTNELHRMDLMVLLDLLGARNPNFYSYITSGDRWFQHSANIEQRLRGANLLSTSNQIFRNDFAPGGIEDDHIPFMQRKVPILHLITTPFPDVWHTNGDNKSVLDYNTIDDLMKILRVFVVEYLQVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7W8</accession>
    <name>E9G7W8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_47057</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84556"/>
    <dbReference type="EnsemblMetazoa" id="EFX84556">
        <property type="protein sequence ID" value="EFX84556"/>
        <property type="gene ID" value="DAPPUDRAFT_47057"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_47057"/>
    <dbReference type="eggNOG" id="KOG2287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036849_0_0_1"/>
    <dbReference type="InParanoid" id="E9G7W8"/>
    <dbReference type="OMA" id="CSHESIV"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="PhylomeDB" id="E9G7W8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX84556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="341" mass="38929" checksum="C0E81239A1710F35" modified="2011-04-05" version="1" fragment="single">LVNLKNFEFLLNSDACGTRQIDLLVIVTSHPGHVALRNAFRRALPIEALRTFNITRVFLLAQINPIQTGYHQVDQHVIEEEYINYNDIVQGDFIESYHNLRYKHVMGLKYSAHYCSQAQLILKMDDDIAVDLFQLLDLVRSKLLTGLQIVGAVLTGDERNPVRDKASKYYVSRDYYAPSKYPPFVSGWAYVTTVQAASQLVRHSESSPFFWIDDIYVTGMLAALSGVNLVDIRTRFTVFVDHLKCCLRNHPNTVACDFFIVPSGDYAELVEAFHRQSLRCRIDSCRTATLEESSDKPSFCVITNIRSQTYNKMDGRIIYGQIIAVYCCRVYGIAYSPPTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9G812</accession>
    <name>E9G812_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calmodulin-lysine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_99402</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="303" mass="34537" checksum="0C17D4A6E6FCC838" modified="2011-04-05" version="1">MEHGEEPSLCAESAKVIARTRWKLLAKVLHKTEKENDESSSHHLVVPTTTSRELYGLFEWAESESKVFWQDNCGQWLQCRSFNHPHFSLNVRFLINQFSIDELTGFNNTGNVCVWPSEEVLAYYCLKNNYVFKEKAVLELGGGMTCLASFAVAKTSDAILVACTDGNPASVENVKRIIEHNNLSSTCPITAQVLDWKNESSFREMESMWDVILCADCLFFDDGREALVDTMQRITTNNGLILIMAPRRGRTLDAFLELCQGKFDIYLDEEFDGDVTLSHQKKLLSSDYNSDHNYPLLVQLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
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        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="120"/>
        </location>
    </feature>
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        </location>
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    <feature type="binding site" evidence="2">
        <location>
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        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
    </feature>
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        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX84280.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
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    <sequence length="606" mass="67527" checksum="00CBB4B0885B2C0F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8W1</accession>
    <name>E9G8W1_DAPPU</name>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX84201">
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        <property type="gene ID" value="DAPPUDRAFT_99965"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_99965"/>
    <dbReference type="eggNOG" id="ENOG502S31M">
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    <dbReference type="InParanoid" id="E9G8W1"/>
    <dbReference type="OrthoDB" id="1422829at2759"/>
    <dbReference type="PhylomeDB" id="E9G8W1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonic acid secretion"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLipase_A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLipase_A2_His_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="SSF48619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240979" evidence="3">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PA2c" evidence="4">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="PA2c" evidence="4">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX84201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="209" mass="23171" checksum="15CFA283ED86E5AD" modified="2011-04-05" version="1">MVIVVLSLFHAIIATASSLSVTKELLIYDGHPFGSRAVLVSSDHNESCQFFGQRNNCCPKIKHRLRLTYILSTQAATGTKWCGPGNIANSYDDLGSRVATDMCCRNHDNCDDSLNPGSCKNGLCNNSVFTKYVFQTKCLNLSVKLNFTSVITHEIFKCVRSNCRCDEKLRQCLLNSNDRASTPVGIIYFNVAAVSCYTQSPDCLNKDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9P0</accession>
    <name>E9G9P0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_28277</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
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    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX83600">
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        <property type="gene ID" value="DAPPUDRAFT_28277"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_28277"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136951_1_0_1"/>
    <dbReference type="InParanoid" id="E9G9P0"/>
    <dbReference type="OMA" id="TALKCIH"/>
    <dbReference type="OrthoDB" id="664730at2759"/>
    <dbReference type="PhylomeDB" id="E9G9P0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53383"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX83600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="92" mass="10027" checksum="D1973F098EBBC98A" modified="2011-04-05" version="1" fragment="single">DPEHSYPGCVNLSFAYVKGESLFMALKDVALSSGSACTSALLEPSYILRTIGAEEDLAYSSIRFGIGRFTTEAAVDYTALKCIHQVTKLREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAD5</accession>
    <name>E9GAD5_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_100433</name>
    </gene>
    <organism evidence="2">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83726">
        <property type="protein sequence ID" value="EFX83726"/>
        <property type="gene ID" value="DAPPUDRAFT_100433"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_100433"/>
    <dbReference type="eggNOG" id="ENOG502S2U8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033667_1_0_1"/>
    <dbReference type="InParanoid" id="E9GAD5"/>
    <dbReference type="OrthoDB" id="1046098at2759"/>
    <dbReference type="PhylomeDB" id="E9GAD5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX83726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="485" mass="55400" checksum="825368F479FA3DA2" modified="2011-04-05" version="1">MPKVKTVISLYSQCINRVKSHLKVFDIPVDDKLLITWRGSPWDREKTESESDMNPFETMPAVLLDAIIQSFCGSQTENTTVKHHINIRNFITTKLQKLIVPSCPYDYEQFSNFFPKLEKLQVLALCYSNIDDSCLKLIATCCKNLRILDITKCKKLTDTGIEWLVPKTAELSKTLLELMVGCQAVTKRGIIFAVQNCPSLEVVENINMFDALVELARSSALAQPSILNTNITRLTLRPADVYISGQLELVVRFCPSVFHMIIVVKEGLTDTDLFCLTSLKDLQILKILRHSSSTLNEITFDKSLAPVLKVIGSLLEVLYIAYFEFVDIWTVVKFCPNLMSLSLRNQCQSLSVLSENEIIQLRHENGRGYFRYLKVIQCGFSLSNDILFGLLSCPLLERVWITHCDALTDDFLQEVIANGSLKNLKILSLNFCYLVTKQGLDALVMNDNRLEQLSFRHCLNITQQNVCDWNEFARCRNWELRIDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAF1</accession>
    <name>E9GAF1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_223322</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83229"/>
    <dbReference type="EnsemblMetazoa" id="EFX83229">
        <property type="protein sequence ID" value="EFX83229"/>
        <property type="gene ID" value="DAPPUDRAFT_223322"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_223322"/>
    <dbReference type="eggNOG" id="KOG1467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1919185_0_0_1"/>
    <dbReference type="InParanoid" id="E9GAF1"/>
    <dbReference type="OMA" id="SIANWRE"/>
    <dbReference type="OrthoDB" id="797227at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX83229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="114" mass="12311" checksum="D9E3BA00C07F0264" modified="2011-04-05" version="1">MSRVGSSQVALVAKAHNVPVLVCCETHKFCERVQTDSFVFNELGDPDDLVAAVKGKPFVHSIANWRELPQLSLLNLTYDVTPGDLVTAVITELGSVPCTSVPVVLRVKHAETAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAQ8</accession>
    <name>E9GAQ8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_48347</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83498"/>
    <dbReference type="EnsemblMetazoa" id="EFX83498">
        <property type="protein sequence ID" value="EFX83498"/>
        <property type="gene ID" value="DAPPUDRAFT_48347"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_48347"/>
    <dbReference type="eggNOG" id="KOG3515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005939_5_0_1"/>
    <dbReference type="InParanoid" id="E9GAQ8"/>
    <dbReference type="OMA" id="MEYSHES"/>
    <dbReference type="OrthoDB" id="118790at2759"/>
    <dbReference type="PhylomeDB" id="E9GAQ8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="110"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="207"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="347" mass="38368" checksum="CFFBAF126B9A668D" modified="2011-04-05" version="1" fragment="single">FVFHRHVVKPLDVRILSSRQPLSSGKKYDLTCQTAGSRPPPTVTWWKDGQLLRRSQETPYDGGNVTLSQLTVQLTPEDDGKKLVCRVENPALGPASAVEDSWLLDVYYVPRVRLELGRNLESEHIREGIDVYFDCHVTSRPSAVRLVWRHQGNVLQHNVSAGVIISESSLVLQRVARSSAGRYTCHASNAEGEGSSSPFHLHVAHKPVCRPEQKNSYGGAKGLTSEVECHVESKPGATSFRWTFNGTGELVDLTSGYRTTADGSISILRYTPRSEMDFGTLLCWAANPLGLQSQPCVFHFYAAGVPDPPRNCSISNQTLSSFEIDCAEGYDGGIPQHFKMHVFDIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9GC36</accession>
    <name>E9GC36_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_315940</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732538">
        <property type="protein sequence ID" value="EFX83210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83210"/>
    <dbReference type="EnsemblMetazoa" id="EFX83210">
        <property type="protein sequence ID" value="EFX83210"/>
        <property type="gene ID" value="DAPPUDRAFT_315940"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315940"/>
    <dbReference type="eggNOG" id="KOG0355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1210862_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GC36"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="229" mass="26286" checksum="C8AC728FA096CDBF" modified="2011-04-05" version="1">MQPLTIYGVYAIILETSSGLLSPTSPVVTAKPNKSASFSVNKAPTPPRRLSWFSSPEYLTDLIQAQSKYLTNQSKFIREACDNVYNFNFKETNVLVEQLRQRGYDPNPIPIWKRKVGLNAEVAKIGEFDYLLAFLKPPYSDLRGSKEELMKNRENRLKRFDVILKKSPVELWRDDLAAFSVAFKKIEDDEQKELASIAESRREEKKSRRDSDSDDAPKPSAKKANLRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9GCD9</accession>
    <name>E9GCD9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_316271</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732539">
        <property type="protein sequence ID" value="EFX82872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82872">
        <property type="protein sequence ID" value="EFX82872"/>
        <property type="gene ID" value="DAPPUDRAFT_316271"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_316271"/>
    <dbReference type="HOGENOM" id="CLU_1066572_0_0_1"/>
    <dbReference type="OrthoDB" id="13797at6657"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 10" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="44"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX82872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="261" mass="28723" checksum="3D6EAF3C748856DD" modified="2011-04-05" version="1">MQPHLFLSPPGSSHQLELTCVSRVGGLRKGGDVLVEGRAKWMIRQHPAKDDDDGLGGDGSSSSSGMRRQAAQTVDNWAGISSRDDDVDYDEDVDVDQLGGVGGGRRRKEKIQPEEKDEEDEDEDAQSISDSENPSRRTQPVVGSHPGKVDTLNGHFNGLYARLTISHPLDEVNPFSGWKVVYKYESESHTVLTAYGRVKIFYETALWVTVNEVLVYSPVKLLCDAGNILCLLLGASVLSFVETADYLAHKLMALRFFSPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEA3</accession>
    <name>E9GEA3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_241453</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82230">
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        <property type="gene ID" value="DAPPUDRAFT_241453"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241453"/>
    <dbReference type="HOGENOM" id="CLU_1867146_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237401" evidence="1">
        <location>
            <begin position="17"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX82230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="137" mass="15611" checksum="184D513DD4528BE4" modified="2011-04-05" version="1">MAIIEVLYCYLIRVLSSSLGADYQTSVNSFSTFPFDCVLVYIHEKMEYFSRYQCSFVKLFLQLQVQTTSSPLNENIEKRLLSITFPAALGDGSKRFQEKGLRNEPPPSSLVQPENVRLLEMTSLLHRNFKALPLGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEK8</accession>
    <name>E9GEK8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PhylomeDB" id="E9GEK8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048856">
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15471">
        <property type="entry name" value="Myo5p-like_CBD_afadin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037977">
        <property type="entry name" value="CBD_Afadin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJ29</accession>
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        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
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        <name evidence="15" type="ORF">DAPPUDRAFT_304007</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFX80375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="541" mass="61212" checksum="B7D48C7654FB4C2D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJ40</accession>
    <name>E9GJ40_DAPPU</name>
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        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="4" type="ORF">DAPPUDRAFT_304094</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80380"/>
    <dbReference type="EnsemblMetazoa" id="EFX80380">
        <property type="protein sequence ID" value="EFX80380"/>
        <property type="gene ID" value="DAPPUDRAFT_304094"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304094"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_0_0_1"/>
    <dbReference type="InParanoid" id="E9GJ40"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="PhylomeDB" id="E9GJ40"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
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    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
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    </dbReference>
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        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX80380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="259" mass="28473" checksum="FB7423BF500C1C79" modified="2011-04-05" version="1">MGGASTKPNQFPWMVELLVVIADAFKQSKVNCGATLIKKQYLLTAAHCIYYRKVVSITAFVGYHYLDVNKFNPTGYEQVIPVSQAFIHDDFDITTMQHDLAILELAKPVRFTDQVHTVCLAQKDSELTDAVVAGWGTTEVYGTKFYPQLLLSTKVPLVKLNQCRRALKEIGRFITDQSICAGGSTSDACAGDSGGPLMASVNSTDSRVRFDQIGVVSWGMGCAQDGIPGIYASVRYHLPWIQQVTRKDTCRPVSPNSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKB0</accession>
    <name>E9GKB0_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_103797</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX80088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="178" mass="19241" checksum="DEE62DDAA540C0E5" modified="2011-04-05" version="1">MEMNGYFKTGRTATDRTATVRTATRKTAMGKTTKGKLTGQPRNNNKFFFFCGAAATSASLATPSASTPGSDNFTSFCVSSSSPANPREELGCSGLKRKCCQHFYNHHTFIAGENAGKEDKQRRADVDREDGDGQDNEGQDDDGKVYVPTTGNNVANTPTITTPKLAKTQPEEDSRNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKR6</accession>
    <name>E9GKR6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">39S ribosomal protein L16, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_92746</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX79922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79922"/>
    <dbReference type="EnsemblMetazoa" id="EFX79922">
        <property type="protein sequence ID" value="EFX79922"/>
        <property type="gene ID" value="DAPPUDRAFT_92746"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_92746"/>
    <dbReference type="eggNOG" id="KOG3422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096518_0_0_1"/>
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            <begin position="36"/>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX79691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX79691"/>
        <property type="gene ID" value="DAPPUDRAFT_319369"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </dbReference>
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            <begin position="26"/>
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        </location>
    </feature>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="132" mass="14957" checksum="C49837AD990C9600" modified="2011-04-05" version="1">MASRINLPWCEPDPACNDAARLCAEVKDDLERISQLQSQFPDRFYLIKFEDLVASVELETEKLYKFLGMPVTDSVKAFLCKHTQSNETRDNPFSTIRHSNTVALGWKSKLSNETIAKITDVCAPTLKMLGFL</sequence>
</entry>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX79237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX79237"/>
        <property type="gene ID" value="DAPPUDRAFT_304949"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S0WQ">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_480823_0_0_1"/>
    <dbReference type="InParanoid" id="E9GMS8"/>
    <dbReference type="OrthoDB" id="1134048at2759"/>
    <dbReference type="PhylomeDB" id="E9GMS8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="113"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX79237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="688" mass="75299" checksum="31FE0B17EA7754C8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9GP92</accession>
    <name>E9GP92_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">XRN2-binding (XTBD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_320229</name>
    </gene>
    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX78722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX78722"/>
        <property type="gene ID" value="DAPPUDRAFT_320229"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_320229"/>
    <dbReference type="HOGENOM" id="CLU_205493_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GP92"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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    </dbReference>
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        <property type="entry name" value="XTBD"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX78722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="67" mass="8150" checksum="6B3638F988A3C17D" modified="2011-04-05" version="1">MEYPPPIEDIRKIYEPYVQWNLRRAFIERNEEKMERRKLLKLSDHLVNPCFINSSLTSLPKKVKDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQM5</accession>
    <name>E9GQM5_DAPPU</name>
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            <fullName evidence="3">Fibrillar collagen NC1 domain-containing protein</fullName>
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        <name type="scientific">Daphnia pulex</name>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732558">
        <property type="protein sequence ID" value="EFX78136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78136"/>
    <dbReference type="EnsemblMetazoa" id="EFX78136">
        <property type="protein sequence ID" value="EFX78136"/>
        <property type="gene ID" value="DAPPUDRAFT_246486"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_246486"/>
    <dbReference type="eggNOG" id="KOG3516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_788139_0_0_1"/>
    <dbReference type="InParanoid" id="E9GQM5"/>
    <dbReference type="OMA" id="IFRTCSE"/>
    <dbReference type="OrthoDB" id="1448661at2759"/>
    <dbReference type="PhylomeDB" id="E9GQM5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
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        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="SSF56496"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241389" description="Fibrillar collagen NC1 domain-containing protein" evidence="2">
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            <begin position="25"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="3">
        <location>
            <begin position="71"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX78136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="352" mass="38368" checksum="8F06CD347E51D33C" modified="2011-04-05" version="1">MANLYPIFIGFFILVSAWTSGSTADDRLSLAQLQEQLQQLKTNYEILEEKFLRLELTQLATGDRQTNQAQTKNAIFRTCSEAHSVDPSLASGMYWIDPDGEGVGDDPIYVSCDMATGKTSVLHDSESPIDYDCNYAPFETNGVTYSWWDDRNGNPQYFWAGSNSSVHTCQCGIDGNCVDSIVKCNCDATVPLLLSDSGVITEKTLLPITKLNFGRTQLSSSSGAHTLGRFECSGGTTVTGMPTSCQDLWRSGHRLSGLYFVMEGKLVKNVYCDFAKLPSEAGFQSLIGYAEVKPKPTYFGIPTSCANLKGTGHTSSGLYSVMGSTMVETVFCDFTKNTGDPGANTNLTLRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GSS7</accession>
    <name>E9GSS7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_106113</name>
    </gene>
    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732562">
        <property type="protein sequence ID" value="EFX77480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77480">
        <property type="protein sequence ID" value="EFX77480"/>
        <property type="gene ID" value="DAPPUDRAFT_106113"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_106113"/>
    <dbReference type="HOGENOM" id="CLU_872278_0_0_1"/>
    <dbReference type="OrthoDB" id="1314521at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="319" mass="36726" checksum="DBE669ACA6B4D7AC" modified="2011-04-05" version="1">MSSSNSFTVKLGYALLEFKFPCGGSIVKQVPEQLKLQFETGKVTARAWEHFCIAKEEFMRKQAICGEPTPLSGHEATERTETEHGEETEQADREGFDKEGGRKKVETERLERERLEREKLESERVERELADREWEEQERTQREWDENEPAPIESDEEDEVMPPKTIVIDSDSSDVLSCSRTGAASRVFVSGGTISVLPKQPPKKRLKRKQKDQLVPPVKKKSSSVKKAKHVTSSESENRFEDKVERRMKNEGHYSRSAMDCSVKWRNMKRVYLQLCVPGTDPKERLRWPYTESLEKLLKNNPTVTLEHVTDVVDSVKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9GSV9</accession>
    <name>E9GSV9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PBPe domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_106141</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX77499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77499"/>
    <dbReference type="EnsemblMetazoa" id="EFX77499">
        <property type="protein sequence ID" value="EFX77499"/>
        <property type="gene ID" value="DAPPUDRAFT_106141"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_106141"/>
    <dbReference type="eggNOG" id="KOG1052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1058688_0_0_1"/>
    <dbReference type="InParanoid" id="E9GSV9"/>
    <dbReference type="OrthoDB" id="218754at33208"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237412" description="PBPe domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="4">
        <location>
            <begin position="101"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX77499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="263" mass="29324" checksum="C22E1BD408BD7A8C" modified="2011-04-05" version="1">MMRLLPFVLFTFLCSANAKQVVDALLRDALPQQEMNPLNGKHLRLIASPEAELYLGALVESLERFKNADFSSPWLSGSFSILIPIPNASTNIGALIQPMRTEVWIYICLSVPTVMASLLGLSKCIIAMNKRMRCKPSEMNFRDSFQVIDYVICVLLSQGAYCGNRQLAIRLAAAAWCLGCFVLVQAYSSTLIAFITSPNNKPIINSVYDIPNVPGLKQTNFSVFTKLGESLREDPNLRCNRTELCLDKVRSGNYVYIHHLPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9GX40</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">DAPPUDRAFT_107445</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732572">
        <property type="protein sequence ID" value="EFX75931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75931"/>
    <dbReference type="EnsemblMetazoa" id="EFX75931">
        <property type="protein sequence ID" value="EFX75931"/>
        <property type="gene ID" value="DAPPUDRAFT_107445"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_107445"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_912947_0_0_1"/>
    <dbReference type="InParanoid" id="E9GX40"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX75931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="376" mass="41222" checksum="7A8FDC1D1179873A" modified="2011-04-05" version="1">MTDKYPSKLKVNTKSEPSPSTQESVEESPGGRVRRSQRTTIITNRLKQLSTKTLEIKQKIEKIREKPRTDRRLAKIATLESELIATDKEFFDTFDKSAIPDSVFNKSLRNVEKEDPFKQTETDEKMDGARAIPLGPLGQQGPPGQQGPPGQQGPPGQQGPPGKPGQDGKPGQNGQPGQNGQPGQDRQPGPPGAPGQVGQQGPPGNQGPPGPQGPPGPLGPQPGPGGIDPADFRTFSAAITAGMLNLAAVNFRKDIPEFSGDLDDNTTFEEWLKKDNRVGTEAGWTDDQKLKVFQSKLIRAAASYNNSLGQNNKANLNVWTTAMEAGFNDATIQDMRKAQLSKIEQKFNERIREYKNRIDELYKSDYGRKPNWQNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9GXE2</accession>
    <name>E9GXE2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_55584</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732572">
        <property type="protein sequence ID" value="EFX75853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75853"/>
    <dbReference type="EnsemblMetazoa" id="EFX75853">
        <property type="protein sequence ID" value="EFX75853"/>
        <property type="gene ID" value="DAPPUDRAFT_55584"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_55584"/>
    <dbReference type="eggNOG" id="KOG0703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023062_1_2_1"/>
    <dbReference type="InParanoid" id="E9GXE2"/>
    <dbReference type="OMA" id="ENGNEMM"/>
    <dbReference type="OrthoDB" id="1097163at2759"/>
    <dbReference type="PhylomeDB" id="E9GXE2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX75853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="108" mass="12300" checksum="3B30D263FBA26423" modified="2011-04-05" version="1">MLRDEDNKYCVDCDAKGPRWDSRNLGIFLCIRCAGINRNLGVHISRVKSVNLDSWAPEQVVSLQQMGSSRARAVYEANLPDSFRRPQTDSTLEGFIRTKYEAKNHIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GY82</accession>
    <name>E9GY82_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_107784</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732574">
        <property type="protein sequence ID" value="EFX75556.1"/>
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    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_107784"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1039230_0_0_1"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="268" mass="30989" checksum="8FD014C085909675" modified="2011-04-05" version="1">MADRIFAPFAIWIFAIHRWRGSVEQFFGFLRSFVFKSELWSHVGVVVAIRRYDAYHMKFASGSVLWRDQRFLRRLVNTDDGEDDHDGIPDQALDNGGDGNNGASHATEESGDDEMAVRIDKKSAAPRANPHALRRSLSRPIWAIFFYGLTAWGELLCYRNLLTVSARCRMARKRWDFEAASCSELDQLFKDRWIAINYWEIVALRLESVTGDELEARSWTLRPTPFNSRFNWDGDHEETSYILTSSATATTRFITTKQRWADRSSCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYE2</accession>
    <name>E9GYE2_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_250360</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX75491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75491">
        <property type="protein sequence ID" value="EFX75491"/>
        <property type="gene ID" value="DAPPUDRAFT_250360"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_250360"/>
    <dbReference type="HOGENOM" id="CLU_2294461_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="101" mass="11525" checksum="AC9B0776B7884373" modified="2011-04-05" version="1">METEKRRSSSPFNIRPMSFIKITFRQLWRVNGRAREHGLYRYSYPDPERQFNSSSYGGLYGRTDDDKTYMAPKAGDCGGCSSPCTPKCVAEKGSRKMKALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2L7</accession>
    <name>E9H2L7_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732586">
        <property type="protein sequence ID" value="EFX74043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74043">
        <property type="protein sequence ID" value="EFX74043"/>
        <property type="gene ID" value="DAPPUDRAFT_109306"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_109306"/>
    <dbReference type="HOGENOM" id="CLU_829668_0_0_1"/>
    <dbReference type="OrthoDB" id="746407at33208"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="335" mass="36776" checksum="B937E4D746A4984E" modified="2011-04-05" version="1">MGSAASAVVRRAASSSLLPSSSGAPSVNAHLVKLQECEKECEENTDTDPKNIQHWALVVHFPRGKKTYIFEAGKGENGLLQASRAEGVDYEIFEKAKYFSTIETCPSELLTKAKQLISPNLLQALYKKIPAIQTYLSYLTGSLGSSGSNAVPDLVSQVVSPTVNDEGKSLFRASLMRSPAHEKSSSEGTDVAGDTEEDYPGSAGWVFLNCPQPGDSGVMLPYLGKLHICRLFFGEASKYDSDTKSFQEEAAHEDSDTLSKDSVRFVSGLKKKFTEALLKELVVEHGKVKSIKITLNYPLVYFQEYHEAMKLENEKCVVSLVCSLKYETETVCIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2N5</accession>
    <name>E9H2N5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyl-D-glucosamine kinase</fullName>
            <ecNumber evidence="2">2.7.1.59</ecNumber>
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        <alternativeName>
            <fullName evidence="4">GlcNAc kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_307522</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type N-acetylglucosamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.59" evidence="2"/>
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        <property type="protein sequence ID" value="EFX74032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74032"/>
    <dbReference type="EnsemblMetazoa" id="EFX74032">
        <property type="protein sequence ID" value="EFX74032"/>
        <property type="gene ID" value="DAPPUDRAFT_307522"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307522"/>
    <dbReference type="eggNOG" id="KOG1794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016274_0_0_1"/>
    <dbReference type="InParanoid" id="E9H2N5"/>
    <dbReference type="OMA" id="DTMGSMF"/>
    <dbReference type="OrthoDB" id="1572762at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045127">
        <property type="term" value="F:N-acetylglucosamine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039758">
        <property type="entry name" value="NAGK_prok_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12862">
        <property type="entry name" value="PTHR12862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732589">
        <property type="protein sequence ID" value="EFX73546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73546">
        <property type="protein sequence ID" value="EFX73546"/>
        <property type="gene ID" value="DAPPUDRAFT_252885"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_252885"/>
    <dbReference type="HOGENOM" id="CLU_1837130_0_0_1"/>
    <dbReference type="OrthoDB" id="460569at2759"/>
    <dbReference type="PhylomeDB" id="E9H3P6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="4">
        <location>
            <begin position="13"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX73546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="140" mass="15537" checksum="2507DFAFB7201D6D" modified="2011-04-05" version="1">MADLVGTWRFGVSIICVIAVLNLMQRLLSYLPESGENRSRPNSPNDNPPTGKSLKKNRVTKGETGKQYLYVFGNLLPQGGSCKSKRIPYRLVAGVWTLPAFFFVQAYTSTLFTYLVTPTQQPLITSVYDIAESSDTSSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9H3Z7</accession>
    <name>E9H3Z7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_253003</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732589">
        <property type="protein sequence ID" value="EFX73613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX73613"/>
    <dbReference type="EnsemblMetazoa" id="EFX73613">
        <property type="protein sequence ID" value="EFX73613"/>
        <property type="gene ID" value="DAPPUDRAFT_253003"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_253003"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011906_0_0_1"/>
    <dbReference type="InParanoid" id="E9H3Z7"/>
    <dbReference type="OMA" id="FLFANTM"/>
    <dbReference type="OrthoDB" id="132850at2759"/>
    <dbReference type="PhylomeDB" id="E9H3Z7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="PTHR11223"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="77"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX73613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="989" mass="112820" checksum="28295DA3DB94F6F4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9H4U4</accession>
    <name>E9H4U4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AKAP7_NLS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_325475</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732592">
        <property type="protein sequence ID" value="EFX73206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX73206"/>
    <dbReference type="EnsemblMetazoa" id="EFX73206">
        <property type="protein sequence ID" value="EFX73206"/>
        <property type="gene ID" value="DAPPUDRAFT_325475"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_325475"/>
    <dbReference type="eggNOG" id="KOG2814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052186_1_1_1"/>
    <dbReference type="InParanoid" id="E9H4U4"/>
    <dbReference type="OMA" id="AVEECFI"/>
    <dbReference type="OrthoDB" id="606751at2759"/>
    <dbReference type="PhylomeDB" id="E9H4U4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010738">
        <property type="term" value="P:regulation of protein kinase A signaling"/>
        <property type="evidence" value="ECO:0000318"/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
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                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241746" evidence="1">
        <location>
            <begin position="26"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX72533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="203" mass="22503" checksum="B769D4DB8D72F2AC" modified="2011-04-05" version="1">MAVISMKFVVTTCTLMLVCMNPAQSKPFNTNINTNYNNNYNTNMSANFLISSLLNYIFNLLQVLQNNEQCSGQYTIPAFPRPDEMNPMLKQHPPAALPESEPPASADPAFVKGDFTILYDYIFNDLIKNRKDGINKDDSSPQDFKEDIEAAVEAFRGPAVPPLLSPIPLDSFGSPQAVQEPAELQAAKMDFLRSFAEAQTRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9H714</accession>
    <name>E9H714_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_326163</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732599">
        <property type="protein sequence ID" value="EFX72439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72439">
        <property type="protein sequence ID" value="EFX72439"/>
        <property type="gene ID" value="DAPPUDRAFT_326163"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326163"/>
    <dbReference type="HOGENOM" id="CLU_033667_0_0_1"/>
    <dbReference type="InParanoid" id="E9H714"/>
    <dbReference type="OrthoDB" id="1282076at2759"/>
    <dbReference type="PhylomeDB" id="E9H714"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX72439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="471" mass="53711" checksum="E96BA86E93D99C8F" modified="2011-04-05" version="1">MTECLLKDYSITEDMFDLLFNSPHVKVLDLSQDYLGTGYDANRNFRIFRLASIKCLQLTTLKIHDGCCVAYFNDKRNSKLEETFTSILQRFEHLQILDLSFTFYGARSMLNLGSTNQPKIRELIVDYCPGVTDTVVEVFCNGQSSLQKLSVNGTEVTHSGIRFAIEHLPELKELNCDNESDLKAFRRIRKETRESKKYSLTKWLMWTPPDEVSFKKGSVSLMVDMCPSLVDVFIHVNDEGFTDEELLGFRKLKQIQNLGIRISFLPSIISISGGVIPLLQARGLTLEELYLSVEVTSEEVYLTIQCCPNIRRLLLAMHNYLYTIPEPVLDYGVHSSLCSPKEVFPLKMLEDISLSSYYSRFPISRKLLLLLLSSPTLTVISIEKCFTLDDQIIEEACARNSFKYLTKLKFHGCSNVSQKGIDFFLNEANPLDEISLKDCGNVNLERMRTMAQEKHWNSVSIQGMATLIPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9H783</accession>
    <name>E9H783_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Gli-Kruppel type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">YY1</name>
        <name evidence="10" type="ORF">DAPPUDRAFT_59123</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YY transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732600">
        <property type="protein sequence ID" value="EFX72414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72414"/>
    <dbReference type="EnsemblMetazoa" id="EFX72414">
        <property type="protein sequence ID" value="EFX72414"/>
        <property type="gene ID" value="DAPPUDRAFT_59123"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_59123"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002678_42_2_1"/>
    <dbReference type="InParanoid" id="E9H783"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017114">
        <property type="entry name" value="YY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037113">
        <property type="entry name" value="TF_Yin_yang"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX72414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="281" mass="30881" checksum="BEB0D332294AF181" modified="2011-04-05" version="1">MYSDTSTASSSRRTANNNPNSRKARNNRSSNTHNSRSNPYDNDGYISNTTTNSRKWEQKQVQIKTLEGEFSVTMWASGAEEDDGFNYSDLGDAELDADYTEYMTGRRLSSSSSGGGGGGGGTGGGGGVTGVDLSDPKQLAEFAKMKPKKERGSEDPIRTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKYVAQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9H7N1</accession>
    <name>E9H7N1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_326407</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SBNO family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX72213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72213">
        <property type="protein sequence ID" value="EFX72213"/>
        <property type="gene ID" value="DAPPUDRAFT_326407"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326407"/>
    <dbReference type="eggNOG" id="KOG1513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000212_2_1_1"/>
    <dbReference type="InParanoid" id="E9H7N1"/>
    <dbReference type="OrthoDB" id="141580at2759"/>
    <dbReference type="PhylomeDB" id="E9H7N1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048583">
        <property type="term" value="P:regulation of response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026937">
        <property type="entry name" value="SBNO_Helicase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026741">
        <property type="entry name" value="SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039187">
        <property type="entry name" value="SNO_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706">
        <property type="entry name" value="PTHR12706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13872">
        <property type="entry name" value="AAA_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13871">
        <property type="entry name" value="Helicase_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_34" evidence="4">
        <location>
            <begin position="24"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase_C_4" evidence="3">
        <location>
            <begin position="550"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX72213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1056" mass="118687" checksum="B6F75B12A4DF3855" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E9H834</accession>
    <name>E9H834_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBM39linker domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_254864</name>
        <name evidence="3" type="ORF">DAPPUDRAFT_260220</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX68370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX72135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68370"/>
    <dbReference type="EnsemblMetazoa" id="EFX68370">
        <property type="protein sequence ID" value="EFX68370"/>
        <property type="gene ID" value="DAPPUDRAFT_260220"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72135">
        <property type="protein sequence ID" value="EFX72135"/>
        <property type="gene ID" value="DAPPUDRAFT_254864"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_254864"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_260220"/>
    <dbReference type="eggNOG" id="KOG0147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1112278_0_0_1"/>
    <dbReference type="OMA" id="INTPNIS"/>
    <dbReference type="OrthoDB" id="873705at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005639">
        <property type="term" value="C:integral component of nuclear inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12286">
        <property type="entry name" value="RRM_Man1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034997">
        <property type="entry name" value="Man1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034394">
        <property type="entry name" value="Man1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13428:SF12">
        <property type="entry name" value="PTHR13428:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX68370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX72135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="202" mass="22840" checksum="D9282A966710C890" modified="2011-04-05" version="1">MTRSLSKKAKSNAKLRDKAVQSPFRPEIQPIEGEDLHVGHRWAFSPDKSTAHEDQSDEASSSNNSSVTPRPKLWQGQAFNTAGVSTQPPYPLTQCLKVRNMFDAEVEEGDSWPVRIQNVILEKADNKGDILHMAIDRGSREGCVYLKCATTDDAGKVYQLLHGWWFDGNLVTVKYLSPERYQYRFPDSVKATFPLQPSNDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9A6</accession>
    <name>E9H9A6_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX71589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71589">
        <property type="protein sequence ID" value="EFX71589"/>
        <property type="gene ID" value="DAPPUDRAFT_326964"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326964"/>
    <dbReference type="HOGENOM" id="CLU_1877542_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="136" mass="15678" checksum="B6321F62D8D1E321" modified="2011-04-05" version="1">MDFGEPLKSLGQRLGFFYDCRYKTNLSFEGNTPVETDKLYKEAIGTTRASMTVFRREKLEETQGENLYQEQPSQQHPLRRWPQTKCGVGKEAEDDSAKAKVAEVIEEENPEIGVRVRTMKPKQRGKRRNGNRGHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HB62</accession>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EFX70996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="131" mass="15041" checksum="99BFD57D79BB7F68" modified="2011-04-05" version="1">MTNEFYGHPNFLQLHTGASAYTTDYHNFINENLDWEELLEDDGSYHKSVSESSIPDDYVNNWLAILNDDNFGVSYEEAVRRSLAGWVLDCNISRAHVLHLLKRLNRDSGLTHLPLGSRTLLKSLRSRIQCC</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <location>
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        <location>
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    </evidence>
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</entry>
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                <person name="Arnold G.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="131" mass="15416" checksum="5CF31E87A47C9707" modified="2011-04-05" version="1">MLSSPHGPQHRRGRRRYKIVVFEFRYVRKFPLQRGEGAFLLPLVRPPVLLPQEKYPAYAVSPNAKNPCAENMPCKAGEYCMKSYERCIPCESLYHRRQMAKHLAQETRPNADRVYQIPESRNTRIIRITLM</sequence>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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                <person name="Bauer D.J."/>
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            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="77" mass="8620" checksum="93E351F07881DE3D" modified="2011-04-05" version="1">MYDYSHMVRLFASDATSTPEIRKCYHQPDNIMLSSDQGKIIPVTDVSRLDLDADSDNTSIPHDPDTPGASYVTFINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJI4</accession>
    <name>E9HJI4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_330417</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732662">
        <property type="protein sequence ID" value="EFX68097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68097">
        <property type="protein sequence ID" value="EFX68097"/>
        <property type="gene ID" value="DAPPUDRAFT_330417"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330417"/>
    <dbReference type="HOGENOM" id="CLU_988910_0_0_1"/>
    <dbReference type="InParanoid" id="E9HJI4"/>
    <dbReference type="OrthoDB" id="1073550at2759"/>
    <dbReference type="PhylomeDB" id="E9HJI4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX68097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="233" mass="27385" checksum="8292DBEFC9A402DF" modified="2011-04-05" version="1">MNQEDFPAEPSEHRKIWSFTTVHMSRRRSGYFRHGIEREVPKVHELVLLDDGDALAMWLDRHPEDIENRFRLKTPLLVAIKHNAYQCFQVLLQRDANIEEYNPQNETALLIAVRLNRMRMADDLIARDASILPEDRMARTVTEILISRDDVETLKLLHIQRGNLLDHDLHNEEFPLTLAISHQARKCIDYILSLKPKAQSFLIRRKYNCPISAAIRRNDVRTMEQLVTLEEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HML0</accession>
    <name>E9HML0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_331475</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732688">
        <property type="protein sequence ID" value="EFX67021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67021">
        <property type="protein sequence ID" value="EFX67021"/>
        <property type="gene ID" value="DAPPUDRAFT_331475"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_331475"/>
    <dbReference type="HOGENOM" id="CLU_135818_0_0_1"/>
    <dbReference type="InParanoid" id="E9HML0"/>
    <dbReference type="PhylomeDB" id="E9HML0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="157" mass="18404" checksum="4D82D0A4E728160A" modified="2011-04-05" version="1">MAAEKDGRNAVYQYLRLYNHENRKKVYKTLDTRFYYNNSDRVEKAIAAMNIMSDETSQKENYDDMPDLEEGPPIKHIPIPPRKVNENIYLARTEMSRLDDGAPSLKLRNFKRLIDKAKSKLPPPPGYRRDYSLITSKSDSDIEKKHYCQQQNNAFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNE8</accession>
    <name>E9HNE8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_331784</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus</location>
            <location evidence="1 11">Golgi stack membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="GL732695">
        <property type="protein sequence ID" value="EFX66758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66758"/>
    <dbReference type="EnsemblMetazoa" id="EFX66758">
        <property type="protein sequence ID" value="EFX66758"/>
        <property type="gene ID" value="DAPPUDRAFT_331784"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_331784"/>
    <dbReference type="eggNOG" id="KOG2619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032075_3_2_1"/>
    <dbReference type="InParanoid" id="E9HNE8"/>
    <dbReference type="OMA" id="ECLPRND"/>
    <dbReference type="OrthoDB" id="551308at2759"/>
    <dbReference type="PhylomeDB" id="E9HNE8"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036065">
        <property type="term" value="P:fucosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="PTHR11929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glyco_tran_10_N" evidence="12">
        <location>
            <begin position="64"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX66758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="415" mass="48215" checksum="7C917745275461C6" modified="2011-04-05" version="1">MGLSAAGLFLTSAAFLYWNEMNNQQQLITFSQSTNKDVTGKIAANVNMKITTIKSTTVKQLETLKIVLYWNTFFNQTDMTFGFGRQPFVDAGCQISNCIATNDRRLFNRSDGVIIHAGDYLEHDLPTYRLPHQRFIFNNYETLPGGNGLPCFSRQHFYNWTMTHRRDSDVYVNRPYGALRRRNHSQLVNQLPPKLNPGQRPPKPEDLFTRKYPELAKRTKLMAWFNSHCPTHSQREDYVKKLTEFIPVDIYGKCGSLECLPRNDPRCDTKVLVNYRFYLAAENSLCPDYVTEKFYRALMNDIVPVVFGGADYAQYAPPNSYVNIADFQSPKELAEYLLLLANNDALYSKYFDWKKDYEVINRPPDGWCDLCAKLNDESLPRKSYSNMGMWCIRKWYLHEEKERRESLADALGIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9HP25</accession>
    <name>E9HP25_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_302671</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732702">
        <property type="protein sequence ID" value="EFX66509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66509">
        <property type="protein sequence ID" value="EFX66509"/>
        <property type="gene ID" value="DAPPUDRAFT_302671"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302671"/>
    <dbReference type="HOGENOM" id="CLU_869481_0_0_1"/>
    <dbReference type="OMA" id="WANGGNK"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003238238" evidence="2">
        <location>
            <begin position="23"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX66509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="320" mass="26645" checksum="336168FA911E9043" modified="2011-04-05" version="1">MKKVLLCNCLLMAVIAISQTNAFFLNKGSSGRAMRSYGGGGGGGYRGSAGGGSTGYGGSSGGGGFGGSSGGGGYRGSSGGGFGGSSGGVGYGSSSGGAGGGSAGYGGSSGGGGFGGTSGGGGYRGSSGGNGGYGSSSGGGSSGYGGPSAGGSGGFGGPSGYGGSSGGSFGGSSGGGGYGSPSGGGSSGYGGQSAGGSSGYGGQSAGGSSGYGGQSAGGSSGYGGQSAGGSSGFGGPSGGSGQYGGSSGGSFGGSSGGVGYGGSSGGSGNIYGGSSGGGGFGGSSGGGGSAGYGSSSGGGFGGSSAGGGNGYGSSSGGGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPA5</accession>
    <name>E9HPA5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_302712</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GL732704">
        <property type="protein sequence ID" value="EFX66442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66442"/>
    <dbReference type="EnsemblMetazoa" id="EFX66442">
        <property type="protein sequence ID" value="EFX66442"/>
        <property type="gene ID" value="DAPPUDRAFT_302712"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302712"/>
    <dbReference type="eggNOG" id="KOG2453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_2_1"/>
    <dbReference type="InParanoid" id="E9HPA5"/>
    <dbReference type="OMA" id="DAWKVYM"/>
    <dbReference type="OrthoDB" id="692580at2759"/>
    <dbReference type="PhylomeDB" id="E9HPA5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043878">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044638">
        <property type="entry name" value="ALDH7A1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521">
        <property type="entry name" value="PTHR43521"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="6">
        <location>
            <begin position="41"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX66442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="517" mass="55373" checksum="293B497E3334FAC3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPB1</accession>
    <name>E9HPB1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_64737</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732704">
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    </dbReference>
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        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX66411.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="513" mass="58302" checksum="9F2633D218E925F2" modified="2011-04-05" version="1"> </sequence>
</entry>
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    <accession>E9HQG2</accession>
    <name>E9HQG2_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_263816</name>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX66020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="107" mass="11892" checksum="2066082C910950FD" modified="2011-04-05" version="1">MSRLQSGDGAIGYDTQDGGSLFHHRHEQQQTGYDHQQQLSDAASQFRGAASNMYQQQQQQQQQQQYAPNRQLHHLAGNSQQQHKHGSPSDGSSSGYGSPDSVLLDER</sequence>
</entry>
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    <accession>E9HQJ6</accession>
    <name>E9HQJ6_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX65989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX65989"/>
    <dbReference type="EnsemblMetazoa" id="EFX65989">
        <property type="protein sequence ID" value="EFX65989"/>
        <property type="gene ID" value="DAPPUDRAFT_263869"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_263869"/>
    <dbReference type="eggNOG" id="KOG0516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="7016at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX65989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="77" mass="9118" checksum="2380359110E0CB89" modified="2011-04-05" version="1">MHNLSILQQSYSELTTASKTRFVDLQSLQEFIPSVMTELAWLNEKEEIEISRDWSLKFLNLIEIQSYYMSTNQTLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9HT97</accession>
    <name>E9HT97_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_265325</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX65033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX65033"/>
    <dbReference type="EnsemblMetazoa" id="EFX65033">
        <property type="protein sequence ID" value="EFX65033"/>
        <property type="gene ID" value="DAPPUDRAFT_265325"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_265325"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_9_3_1"/>
    <dbReference type="InParanoid" id="E9HT97"/>
    <dbReference type="PhylomeDB" id="E9HT97"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034620">
        <property type="term" value="P:cellular response to unfolded protein"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051085">
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        </source>
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        </source>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <end position="94"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="270" mass="29780" checksum="ED30A6578ABCF10E" modified="2011-04-05" version="1" fragment="single">ALIVAAQNTACRAMTALIRLGADVNHQDYKGNTALHYAVWTMSEKVVEILSTAVADFNIQNSDGQTAVHLLAPTNNYKLARRICRNLPQLKMDMMDINGHDPFIAAVVHGSLRMVDYFLHLGYDPTTKTRLDKTPLHIAVELNNLPMIKLLARSHQVNNIDDNGHSALTIAVGRGIEAAVDVLLQQDADISQLDNTGNSMLHIACTGKSENILRHMFEHFLDLNVRNSTEETPLHLACALNNTAVVSELCARRADITAQDSRKRTPLMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HWD3</accession>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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                <person name="Manak J.R."/>
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    </evidence>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SSF50044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="264"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX63144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="464" mass="53063" checksum="42571FD54990928A" modified="2011-04-05" version="1">MYSSSGSLVVHKIAVHSENGNVFKCDLCVKFFRNKESLNMHNQSIHSRNSVTCETCERVFRSMIYLNAHKRNVHTGKKWECDLCEKSFNTKSYLGAHKKTVHTGKKMQCDLCEKSYKTMKILDVHKRNVHTEKKWECETCEKVFRSMLYLNAHKKTVHTGKKWECDLCEKSFNTKSYLGAHKKTVHTGKKMQCDLCDKSYKTKGNLDAHKRTVHTGKKVECDLLPLSLSALPLDVHSLQHTVPLNTINPQTETSADMLEIPGKGRCYVYLAKYTYDPFTQSPNDNPEAEVSLASGDYILVWKTMDGDGFYEGESLDGRKGLVPSNFIKRLQGEDLVKFNRAAVLGLQICGDDSSKTTSPRDLLGVSPNHKQSSMSSHFEGKWDYRNRRPMRAYDSSRVGHPSINQLPSLPHQHLQQQLQQHQQQQILPHQQVITNNNPIEQGESNVKKTRFSNLKNIQIQYSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9HYP8</accession>
    <name>E9HYP8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="20">LOPA10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOPA10</name>
        <name evidence="20" type="ORF">DAPPUDRAFT_346968</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL733199">
        <property type="protein sequence ID" value="EFX63132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX63132"/>
    <dbReference type="EnsemblMetazoa" id="EFX63132">
        <property type="protein sequence ID" value="EFX63132"/>
        <property type="gene ID" value="DAPPUDRAFT_346968"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_346968"/>
    <dbReference type="HOGENOM" id="CLU_009579_3_0_1"/>
    <dbReference type="InParanoid" id="E9HYP8"/>
    <dbReference type="OrthoDB" id="911005at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008020">
        <property type="term" value="F:G protein-coupled photoreceptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071482">
        <property type="term" value="P:cellular response to light stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000856">
        <property type="entry name" value="Opsin_RH3/RH4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00577">
        <property type="entry name" value="OPSINRH3RH4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="14 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F1_2" evidence="19">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFX63132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="293" mass="32320" checksum="543EAB4F1AB65B32" modified="2011-04-05" version="1">MFVVNLAFSDFCMMISQFPMFVHNSFNGGIWLFGPAACELYACLGSIFGATSICTMAVIAYDRYNVIVKGMAGTKMTSKRAATLIACCWIYATGWSITPYFGFGRYIPEGILDSCSFDYLTRDEQTKAFGLCLFVFLYCIPLAFITYCYYFIVKTIFDHEKTLRDQAKKMNVTSLRSNADSNAASAEIKIAKVALCNIALWAAMWTPYAAIVLKGLLGDQSTITPLVTILPALIAKSASICNPVVYAISHPKFRLALQEKYPWFCINEPVKSDNESICSTKTGASSSSTTESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9I006</accession>
    <name>E9I006_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_336617</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX62674.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="690" mass="80348" checksum="C609FFC1C6440046" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_302172"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502T1HC">
        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="22"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="39"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX62043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="186" mass="20236" checksum="8530E7A0A7991118" modified="2011-04-05" version="1">MKYAQTLGCMVAVILLSCGCLAKPSNRETVMENEKELDPAFILRWTVIEGTGDIEIEIQANCTGWTGISFAEGQIGQPGSYGDVIMGGFNDELQMGYSEDRHIALENPDPANGHLFDDSNDILLKSARYEEPWTIIRILRSLNTGDSQDIPIVPGPMTVSWTISPTDDTSSGHGSAGLSRVTFIPL</sequence>
</entry>
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        </lineage>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX61432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="371" mass="40334" checksum="FA05AE1A80FA8475" modified="2011-04-05" version="1">MRLQRALGRLRQKLVDLLPIAVGAGMLEELLQNRASASAPAGWAARIASAAHATATLSPATQGSPSGITARQALQWLAVTCLCIVTSLAVLNRNASSRILPESSSTSSAPADRETNLSTRRLARSTSTRENPTLIQPGPEAQVLLARLQAILLSPVQDTSFPPQDLRDCIHELEPYPEPTFQLLATTLRSVPNESAAVAPQAKSRAAWGLWLLTEQAPTFRPRAQDELLAIIRNPEATTQWSDAAMVMTHIGPDPRSITELAIALGSNPLAIDMCLYFWESAARRHPDITVETLLPWLDLELGYRFTAAHTMAFIGGEQRAEFTPILMEAFEHPFGTQSSGIRQAALKALQRLGPLASANAPWLLQKRDEP</sequence>
</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
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                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_340564"/>
    <dbReference type="HOGENOM" id="CLU_1788797_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="145" mass="16804" checksum="F53386EB5D659941" modified="2011-04-05" version="1">MEELVLEPRYLFQFLCTGRIAPQANVVEFKTYKTTSTRKKMHPAFNVFKILDGRRSFYVSAERQVKGVVVQFSSNEKFVLNKLAGVPRCDAKDLHLQCTKKVRLSVEQLIRILTEEDFLDKPYSLSTNNSQQFVQKLNHFVSIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9I4V4</accession>
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        <recommendedName>
            <fullName evidence="2">Pept_C1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_274869</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL735216">
        <property type="protein sequence ID" value="EFX60976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60976">
        <property type="protein sequence ID" value="EFX60976"/>
        <property type="gene ID" value="DAPPUDRAFT_274869"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_274869"/>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202752_0_0_1"/>
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    <dbReference type="OMA" id="IANNWNT"/>
    <dbReference type="OrthoDB" id="1275401at2759"/>
    <dbReference type="PhylomeDB" id="E9I4V4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pept_C1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX60976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="71" mass="7850" checksum="1503119ADB6D1068" modified="2011-04-05" version="1">MVRRLPTNVHGKAVGGHAIRILGWGVEEGVPYWLIANNWNTDWGDNGYIKLLRGKDHCGIESQITGGLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9I5K2</accession>
    <name>E9I5K2_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL735695">
        <property type="protein sequence ID" value="EFX60728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60728">
        <property type="protein sequence ID" value="EFX60728"/>
        <property type="gene ID" value="DAPPUDRAFT_275873"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_275873"/>
    <dbReference type="HOGENOM" id="CLU_963984_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="289" mass="32487" checksum="E04B72FB04DC0F92" modified="2011-04-05" version="1">MLLLREALFHKRIGECDDARTKVKQAIAGADIGLRDGGLLSSAKFLLDRIDYDESPADVFQRLAQFGPEPAPLFAVDIRTAPHWHNLRGLLARRALLEASKEFADRTQIEGLHQSALLHLETAMYFALALKDFDLLQAIAANLTLHLQSVIALDLADVEQVYAWHILVMSYTNKLDVGKDSAWELIFLGEFWLDNQEVLKKPRKGAKSAYIGYALPSEEKFYVDCIKRLDECADARQVGIARLNYLRFARDYLSQAKLAAATKSFNVLLENTKGLREILISEGYGSHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9I651</accession>
    <name>E9I651_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_123834</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL736164">
        <property type="protein sequence ID" value="EFX60529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60529">
        <property type="protein sequence ID" value="EFX60529"/>
        <property type="gene ID" value="DAPPUDRAFT_123834"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_123834"/>
    <dbReference type="HOGENOM" id="CLU_682536_0_0_1"/>
    <dbReference type="OrthoDB" id="222689at2759"/>
    <dbReference type="PhylomeDB" id="E9I651"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX60529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="404" mass="46136" checksum="369A1449CC16D326" modified="2011-04-05" version="1" fragment="single">MDPSLLDPEEERTEVNTLAVIFPNIELKQEDLDKDPDLIPDRITELTDLQSPEELDEYRRYYRALCRHRRKIYLHARLLQKKLIEKKYKKNSKRLLDFIHAKLVNMYDITGGQKRSFTVGMKNLVRAITFLSKEVSSRQKVTLELQAKAARQAEDEKEKALSQIQALRAVRADQQAAESTGNLPPNVQHSMPNEPGIGRPDGPSDRHVTYGANVTPSRESLATSTSRGYSRGRRGGTRGRGNGAPFRDDRFFGSSTTDESDPTTVSLQTLVEALKSLKGRKPDMPDYRGLDKPKLECFTGDASVYAHWKKKFLLAHEGRNLPDVYLANTLHTLLKGEARAKVEVHFTADWTGENYQQMWTLLDDYYGSRHIQDRCIQDRAEKIIPLNHETLSTVSMFYDEITVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9I672</accession>
    <name>E9I672_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Light-independent protochlorophyllide reductase subunit B</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_342996</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (ChlN-ChlB) is the catalytic component of the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate = 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:28202"/>
            <dbReference type="Rhea" id="RHEA-COMP:10002"/>
            <dbReference type="Rhea" id="RHEA-COMP:10004"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83348"/>
            <dbReference type="ChEBI" id="CHEBI:83350"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.3.7.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; chlorophyll biosynthesis (light-independent).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Protochlorophyllide reductase is composed of three subunits; ChlL, ChlN and ChlB. Forms a heterotetramer of two ChlB and two ChlN subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ChlB/BchB/BchZ family.</text>
    </comment>
    <dbReference type="EC" id="1.3.7.7" evidence="4"/>
    <dbReference type="EMBL" id="GL736222">
        <property type="protein sequence ID" value="EFX60508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60508">
        <property type="protein sequence ID" value="EFX60508"/>
        <property type="gene ID" value="DAPPUDRAFT_342996"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_342996"/>
    <dbReference type="HOGENOM" id="CLU_1248052_0_0_1"/>
    <dbReference type="OrthoDB" id="538441at2759"/>
    <dbReference type="UniPathway" id="UPA00670"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000510">
        <property type="entry name" value="Nase/OxRdtase_comp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00148">
        <property type="entry name" value="Oxidored_nitro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_nitro" evidence="8">
        <location>
            <begin position="28"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX60508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="222" mass="24103" checksum="7CDF6634CA25AF9E" modified="2011-04-05" version="1" fragment="single">MNQVSPPPSTVAKPKSPLILDHDRAGGYWGAVYVFTAIKGLQVVIDGPVGCENLPVTSVLHYTDALPPHELPIVVTGLAEEQLGREGTEGAMKRAHATLDPELPAVVVTGSIAEMIGGGVTPEGTNIARFLPRTIDEDQWQCANRAMYWLWSEYGLRKVPARKPFEERPVGEKPRVNIIGPCYGTFNSPSDLAEIRRLVQGIGADVNMVFPLTSHLADVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9I6H7</accession>
    <name>E9I6H7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_343955</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL736468">
        <property type="protein sequence ID" value="EFX60403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX60403"/>
    <dbReference type="EnsemblMetazoa" id="EFX60403">
        <property type="protein sequence ID" value="EFX60403"/>
        <property type="gene ID" value="DAPPUDRAFT_343955"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_343955"/>
    <dbReference type="eggNOG" id="ENOG502SFDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160655_4_0_1"/>
    <dbReference type="InParanoid" id="E9I6H7"/>
    <dbReference type="OMA" id="GVIHKNA"/>
    <dbReference type="OrthoDB" id="1652982at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX60403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="93" mass="10218" checksum="C9BC8C58C6703DBC" modified="2011-04-05" version="1" fragment="single">MATKPKKKNPRLASGRKRVRQDIKLNAANTSLRSKYRTAVKNVEKAVLAGDKTKAAELFAKMQAVVDTVADKGIFHKNKAARDKSRLSAKGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9I7I0</accession>
    <name>E9I7I0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_279632</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL737238">
        <property type="protein sequence ID" value="EFX60050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60050">
        <property type="protein sequence ID" value="EFX60050"/>
        <property type="gene ID" value="DAPPUDRAFT_279632"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_279632"/>
    <dbReference type="HOGENOM" id="CLU_3108481_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="51" mass="5848" checksum="9D5273403F86C6B9" modified="2011-04-05" version="1">MYAEYSAELASGNSEHKSECALLASKFYLYFNLLRRYYVCRAQISDGGELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9I7V4</accession>
    <name>E9I7V4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_280330</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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                <person name="Thomas W.K."/>
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        <name type="scientific">Daphnia pulex</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
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</entry>
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    </protein>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX88913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUM5</accession>
    <name>E9FUM5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aquaporin-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aquaglyceroporin-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_311096</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88757"/>
    <dbReference type="EnsemblMetazoa" id="EFX88757">
        <property type="protein sequence ID" value="EFX88757"/>
        <property type="gene ID" value="DAPPUDRAFT_311096"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_311096"/>
    <dbReference type="eggNOG" id="KOG0224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_9_1_1"/>
    <dbReference type="InParanoid" id="E9FUM5"/>
    <dbReference type="OMA" id="MSAGNME"/>
    <dbReference type="OrthoDB" id="1246320at2759"/>
    <dbReference type="PhylomeDB" id="E9FUM5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006833">
        <property type="term" value="P:water transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023275">
        <property type="entry name" value="Aquaporin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02015">
        <property type="entry name" value="AQUAPORIN3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX88757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="303" mass="32839" checksum="4FDB11B7D1135BD3" modified="2011-04-05" version="1">MAPKLMKMIRVEAPLLREIMAEFLGTFILVLFGDASVAQSKLSNEANGDFFSINWGWAVGVMMGVLVAGGVSGAHLNPAVTLAMACAGRIAIIKVFFYMLAQYLGAFAAAASVLGVYSDAIEYYSNTNHNGTLYMNNEANDPGLAGIFSTYPAPWLSIAGGIGDQILGTMLLLLCICAITDKKNTQIPSALVPMYVGFTILGIGVCFGANCGYALNPARDLSPRLITLIAGWDQSFSWNNYNWFWIPIVGPHIGAILGVFIYIAFVEAHWPEEGDEVVPITVPRANFNKERGEKIQNMDMESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9FWZ1</accession>
    <name>E9FWZ1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_42666</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX87979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87979"/>
    <dbReference type="EnsemblMetazoa" id="EFX87979">
        <property type="protein sequence ID" value="EFX87979"/>
        <property type="gene ID" value="DAPPUDRAFT_42666"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_42666"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002678_42_18_1"/>
    <dbReference type="InParanoid" id="E9FWZ1"/>
    <dbReference type="OMA" id="ITHREKK"/>
    <dbReference type="OrthoDB" id="165439at2759"/>
    <dbReference type="PhylomeDB" id="E9FWZ1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX87979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="79" mass="9181" checksum="E3CB4CA2C1CAA1CD" modified="2011-04-05" version="1" fragment="single">QMCSKVFTSTSALAKHKLTHSDERRFSCQLCGKAFKRQDHLNGHLITHREKKPFECRADGCGKSYCDARSLRRHQDNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXH8</accession>
    <name>E9FXH8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_221306</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88266">
        <property type="protein sequence ID" value="EFX88266"/>
        <property type="gene ID" value="DAPPUDRAFT_221306"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_221306"/>
    <dbReference type="HOGENOM" id="CLU_589590_0_0_1"/>
    <dbReference type="InParanoid" id="E9FXH8"/>
    <dbReference type="OrthoDB" id="876073at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236489" evidence="3">
        <location>
            <begin position="19"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX88266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="464" mass="49644" checksum="68C61A06990C1133" modified="2011-04-05" version="1">MKMIPAVILICIATTVTSAPTSQYTINVDGPEGRHVQMGEPGKAVSGYYTSRSLDGLMEYKTNYEADDKGYRATGDHLPVAAVLPAVRSLDSAPEGYVFKYEAPGGHSHYMMGQPGKSVQGSFTYVDAEGRSRRVDYEADEKGYRVLPIKEEETPIAIASVSADAEVVKAAEPAIPVAAEPIPETVVAPITQVVAEPVVAAPVPEAVAEPVVVAAAADPAPKPVVVADPSSRTILATEEKPVEMMYYQKDTGAAEAATRTISEEVKPAVMMYYPKDTEVAKEAEPATRTIPEEEKPAYMMYYIKDAGVAEPASRTIPEEQPVAMMYYPKEAEVAKEAQPASRTIPEEQPAAMMYYPKEAEVAEPSSRTIQGASEAVAEPAQTAVETVASDPAPAQPVAESTQSNTHGKAVYALPIALPGATYYGLPTRFVQPALPAFHYAAPYAYAYGYNVGYPLTGGSYVYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYJ7</accession>
    <name>E9FYJ7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_235238</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87539"/>
    <dbReference type="EnsemblMetazoa" id="EFX87539">
        <property type="protein sequence ID" value="EFX87539"/>
        <property type="gene ID" value="DAPPUDRAFT_235238"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_235238"/>
    <dbReference type="eggNOG" id="KOG0164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_7_7_1"/>
    <dbReference type="InParanoid" id="E9FYJ7"/>
    <dbReference type="OMA" id="QDVKYGH"/>
    <dbReference type="OrthoDB" id="122881at2759"/>
    <dbReference type="PhylomeDB" id="E9FYJ7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030050">
        <property type="term" value="P:vesicle transport along actin filament"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 7" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="37"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="9">
        <location>
            <begin position="851"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="7">
        <location>
            <begin position="611"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="130"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX87539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1054" mass="120555" checksum="5EECB3A5380CEE0E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZA9</accession>
    <name>E9FZA9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DAPPUDRAFT_43397</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
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                <person name="Robertson H.M."/>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Zdobnov E.M."/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="COG1"/>
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        <property type="entry name" value="PTHR31658"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="827"/>
            <end position="866"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX86508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="895" mass="100324" checksum="0E2E24D008668860" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1P0</accession>
    <name>E9G1P0_DAPPU</name>
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        <submittedName>
            <fullName evidence="5">EOG090X0EA1</fullName>
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    <gene>
        <name evidence="5" type="primary">EOG090X0EA1</name>
        <name evidence="4" type="ORF">DAPPUDRAFT_307757</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
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            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TCO</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015532">
        <property type="protein sequence ID" value="SVE85151.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86777"/>
    <dbReference type="EnsemblMetazoa" id="EFX86777">
        <property type="protein sequence ID" value="EFX86777"/>
        <property type="gene ID" value="DAPPUDRAFT_307757"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307757"/>
    <dbReference type="eggNOG" id="KOG1655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079409_1_0_1"/>
    <dbReference type="OMA" id="MEQAQTM"/>
    <dbReference type="OrthoDB" id="1301560at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="PTHR22761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="99"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX86777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SVE85151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="220" mass="24694" checksum="97D127F21E53DB3D" modified="2011-04-05" version="1">MNRIFGRGKPQQPAPNMSDMISKVDERGDNIEKKISKLDVELKKYKDQMAKMREGPAKNAVKQKALRVLKQKKMYEQQAGNLRQQSFNMEQANYATQTLKDTQSTVKAMQMGLKEMKKEFKKINIDQVEDIQDEMADMLEQADEVQEALGRSYGTPDIDEDELEAELEALGDEMLGDEDSSYLDDAIKAPSAPDREPGSESVNVDGVAVDEFGLPKIPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9G476</accession>
    <name>E9G476_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative allatostatin C preprohormone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_290676</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85706">
        <property type="protein sequence ID" value="EFX85706"/>
        <property type="gene ID" value="DAPPUDRAFT_290676"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_290676"/>
    <dbReference type="eggNOG" id="ENOG502S8U2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160227_0_0_1"/>
    <dbReference type="InParanoid" id="E9G476"/>
    <dbReference type="OrthoDB" id="1549004at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240016" evidence="1">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX85706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="98" mass="10688" checksum="93BFB8E27C138AF3" modified="2011-04-05" version="1">MMAKISAVVPVAILLYLAASGAAKSTDREETESTDFGQDIEVLGAVPDDGSVETALLNYLFAKQIVARLRTNANPQDLMRKRSYWKQCAFNAVSCFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9G4I2</accession>
    <name>E9G4I2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_237828</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM154 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85306">
        <property type="protein sequence ID" value="EFX85306"/>
        <property type="gene ID" value="DAPPUDRAFT_237828"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_237828"/>
    <dbReference type="HOGENOM" id="CLU_397546_0_0_1"/>
    <dbReference type="InParanoid" id="E9G4I2"/>
    <dbReference type="OrthoDB" id="1300537at2759"/>
    <dbReference type="PhylomeDB" id="E9G4I2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033336">
        <property type="entry name" value="SAXO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516">
        <property type="entry name" value="PTHR31516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX85306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="693" mass="78100" checksum="54A802DA3F8BC8D8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9G4K8</accession>
    <name>E9G4K8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_98857</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85539">
        <property type="protein sequence ID" value="EFX85539"/>
        <property type="gene ID" value="DAPPUDRAFT_98857"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_98857"/>
    <dbReference type="HOGENOM" id="CLU_306357_0_0_1"/>
    <dbReference type="OrthoDB" id="1729024at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX85539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="967" mass="105845" checksum="56DFF0E55037D21C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9G609</accession>
    <name>E9G609_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_314403</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:58116"/>
            <dbReference type="Rhea" id="RHEA-COMP:14610"/>
            <dbReference type="Rhea" id="RHEA-COMP:16010"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140576"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:62016"/>
            <dbReference type="Rhea" id="RHEA-COMP:16010"/>
            <dbReference type="Rhea" id="RHEA-COMP:16011"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132085"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KDELC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX85077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85077"/>
    <dbReference type="EnsemblMetazoa" id="EFX85077">
        <property type="protein sequence ID" value="EFX85077"/>
        <property type="gene ID" value="DAPPUDRAFT_314403"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_314403"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041919_0_0_1"/>
    <dbReference type="InParanoid" id="E9G609"/>
    <dbReference type="OMA" id="MFMDATL"/>
    <dbReference type="OrthoDB" id="547457at2759"/>
    <dbReference type="PhylomeDB" id="E9G609"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046527">
        <property type="term" value="F:glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236699" description="CAP10 domain-containing protein" evidence="8">
        <location>
            <begin position="26"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="25"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="CAP10" evidence="9">
        <location>
            <begin position="225"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX85077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="502" mass="58400" checksum="B8FCE64A7C454EFF" modified="2011-04-05" version="1">MSVFECPFVLIWILIFIFIVNPTASVENDPSQCVLTGPGLIPNRIVLPARYFLIQSTERCNVSQVDIIVELKGLSEHGPCRVWTQILDRRDGSFIVRYKMFQYCDDMEIHVTWKGHHLADSPYSYKGRVYAESCDCPLDSIDEMINDYQCSVNVAQIDHDLNQFQNVDFNQVLTEAMKRFSHAGSYSFCHYAVLDNKVYRRCYGQHVGFNMFMDNILLSLSRKAVLPDMEFLINLGDWPLVKKNILPIIPIFSWCGSTQTADIVMPTYDITEASLECMGRVTLDMLSVQSNPDTKWENKQEKAFWRGRDSRRERLNLVKLSRQRPELINASLTNFFFFRDEEKTYGPKEDHISFFKFFDYKYQLNIDGTVAAYRFPYLLAGDAVVFKQDSEYYEHFYSDLKPGVHYVPIKADLSDLVKKIQWAKTHDEEVRKIGINGRQYAVNHLLPKDVICYHAILFKKWSQKLKNPIRVHDQMTLVKPSNSTDKRLGNCQCLKKSTHVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7C6</accession>
    <name>E9G7C6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_314756</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
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                <person name="Thomas W.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX83876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX83876"/>
        <property type="gene ID" value="DAPPUDRAFT_315349"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315349"/>
    <dbReference type="HOGENOM" id="CLU_2087209_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX83876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="117" mass="12592" checksum="F0FEA0D853482961" modified="2011-04-05" version="1">MHCRKEQGQLISTEELEEELEGMISSVDKAKSGTQDQTKEMIKIFTAENVERCSPATAASTCHPLAAVMTNTGSICGLIECIVEEEQGQLISTEELEGMISSVDKAKRVGGDDKLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9J6</accession>
    <name>E9G9J6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_315370</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83577">
        <property type="protein sequence ID" value="EFX83577"/>
        <property type="gene ID" value="DAPPUDRAFT_315370"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315370"/>
    <dbReference type="HOGENOM" id="CLU_714264_0_0_1"/>
    <dbReference type="OrthoDB" id="1902184at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX83577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="387" mass="44436" checksum="7184D797867E9C0C" modified="2011-04-05" version="1">MDSYCHKTLIIYGSPTVSDDLIYQTIFVYRYKFGKMVCVNVLRHDDEVEFNDVDAAEVEPERDVYGTGYEISVSIREDRVELGERALVPAASLVPAASSVLNDSSDDEDVEEEEQNMWHVIDSALRKLLDDDLSQELKLRIVFATGSRRRIANPDSYVIKITETTSIDGLVKAKLQIQIVVKKSSLSFLTAEKLEREALALLTPEQRTKVDEDEAVKLSLRRRDCTSGKGSEKRKKDAFPINREVIKGLKALKVLNEGKEQGEQDVASSLIRRIYSPLYVQLHKKTSKAPKRQECGDQFIPLPEQELKQIRVYHGTYGGRTNDRHKSIENYLTQKFNHCAETNKKWLRKYKALKYKLTEDEDASLWSYPEDEADSSDGIKRRRMLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9S6</accession>
    <name>E9G9S6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_239657</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83834">
        <property type="protein sequence ID" value="EFX83834"/>
        <property type="gene ID" value="DAPPUDRAFT_239657"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_239657"/>
    <dbReference type="HOGENOM" id="CLU_2186551_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX83834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="109" mass="11275" checksum="46E74DD625773F48" modified="2011-04-05" version="1">MDPGMDFNENDEMRLLQDGVANAATISMLIILIMELEANGEMRVLQVGEAAEGAANPAADAANPAAGVANEAGLPENPIPGFRFNTHANFLAGCVFLSGSGVELISIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAX6</accession>
    <name>E9GAX6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">COX6C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_301871</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome c oxidase subunit 6c family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83335"/>
    <dbReference type="EnsemblMetazoa" id="EFX83335">
        <property type="protein sequence ID" value="EFX83335"/>
        <property type="gene ID" value="DAPPUDRAFT_301871"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301871"/>
    <dbReference type="eggNOG" id="ENOG502SEI2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196254_0_0_1"/>
    <dbReference type="InParanoid" id="E9GAX6"/>
    <dbReference type="OMA" id="YKNYDPM"/>
    <dbReference type="OrthoDB" id="1618740at2759"/>
    <dbReference type="PhylomeDB" id="E9GAX6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.93.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034884">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc/VIIs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037169">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02937">
        <property type="entry name" value="COX6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81415">
        <property type="entry name" value="SSF81415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="COX6C" evidence="8">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX83335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="80" mass="9090" checksum="828EFD4A1D693447" modified="2011-04-05" version="1">MSAKAVATLAKPKMRGLLTDQIKKNLVIATVLSFGTMFAYKFLVADKRKTAYAEFYRTYDIEKEYNRMKQAGIFTSARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9GCM7</accession>
    <name>E9GCM7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_240814</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732539">
        <property type="protein sequence ID" value="EFX82837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82837">
        <property type="protein sequence ID" value="EFX82837"/>
        <property type="gene ID" value="DAPPUDRAFT_240814"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_240814"/>
    <dbReference type="HOGENOM" id="CLU_057926_0_0_1"/>
    <dbReference type="InParanoid" id="E9GCM7"/>
    <dbReference type="OrthoDB" id="188544at2759"/>
    <dbReference type="PhylomeDB" id="E9GCM7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX82837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="340" mass="38273" checksum="CE33545D72B0620E" modified="2011-04-05" version="1">MEKIVLDILSNHMRFTYEIVPPSDILSSGYLQRNGSWTGTTGQLQRREVDMCVTWGAPSLAKTSVMDVSYPVVYVDSSIMIPFPRQKRLTLRNQASTFRMTLFVSVFGVFIITNYYTASYTSMLSSPNFKPIVNSIEDLATSDSVKTLLIKGSSTDEYIMSSTDPTLKKISDQMRRYPERRILDAYTVEDISTVVKEDSALIIVKSNGESLIEQSYKINKKCRVTLAEKTFFSRQQTFSYPKKSPIAKEIDYDLLLLHQAGLIQYAEKRAQMGHNPCRISDMKKAQSEKIAPLKLRNQMSAAFVFLSIGFGLGVLVFIGELIAAKIKKKSRIISGSVTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E9GCR1</accession>
    <name>E9GCR1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">EOG090X0906</name>
        <name evidence="9" type="ORF">DAPPUDRAFT_299714</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TCO</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732539">
        <property type="protein sequence ID" value="EFX82820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015354">
        <property type="protein sequence ID" value="SVE84973.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX82820"/>
    <dbReference type="EnsemblMetazoa" id="EFX82820">
        <property type="protein sequence ID" value="EFX82820"/>
        <property type="gene ID" value="DAPPUDRAFT_299714"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299714"/>
    <dbReference type="eggNOG" id="KOG1433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_0_2_1"/>
    <dbReference type="OMA" id="TFRIYLR"/>
    <dbReference type="OrthoDB" id="877394at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:strand invasion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01123">
        <property type="entry name" value="Rad51_DMC1_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033925">
        <property type="entry name" value="Rad51_DMC1_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="100"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="8">
        <location>
            <begin position="278"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX82820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="SVE84973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="341" mass="36867" checksum="07376868365A458C" modified="2011-04-05" version="1">MATALRNLNEEEENVVEALEQTVFSAISKLEGNGISGADIKKLQEAGYHTVESVAYVPKKTLITIKGVSEAKADKIIAEAQKMVPMGFSTATEYHQKRAELVQVTTGSKELDKLLGGGIETGSITEIFGEFRTGKTQLCLTLAVTCQLPIDSGGAEGKCLYIDTEGTFRPERLLAVAERYGLSGSDVLDNVACARAFNTDHQSQLLIQASAMMADSRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIMAHASTTRLYLRKGRGETRICKIYDSPCLPESEAMFAILPDGIGDSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9GCY6</accession>
    <name>E9GCY6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_48825</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Tsuchiya D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GFV2</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <location>
            <begin position="71"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
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    <name>E9GH43_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_242637</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX81138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81138">
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        <property type="gene ID" value="DAPPUDRAFT_242637"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_242637"/>
    <dbReference type="HOGENOM" id="CLU_2374893_0_0_1"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX81138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="95" mass="10386" checksum="1ED8CD95050DED94" modified="2011-04-05" version="1">MTESHSHFDAAGKAVSYQVGANFENVSDLGSLKKELRHHNTLFRGQIQPVRTAFSEKKVYATAFLDIKIAFDSAWHPAPAILAGLAGRGCPGFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GHD9</accession>
    <name>E9GHD9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_317936</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732544">
        <property type="protein sequence ID" value="EFX81197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX81197"/>
        <property type="gene ID" value="DAPPUDRAFT_317936"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_317936"/>
    <dbReference type="HOGENOM" id="CLU_1442455_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GHD9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX81197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="188" mass="21321" checksum="F285DAB169BEEA48" modified="2011-04-05" version="1">MFPVRVEPVFGNHVEQFSQIAITDGVPNDIWTYAENAPDLISKFSLKPAIISQTQTAEYDQSSDIIESYTNQKQNHLTYLLTLQKLYESTPNYSLLPSTGKDLMTIDGNDWPDSSNEPFTKKLAAVPINGGKFVHFGVENALNGTSAGLIHRDADLIQFFDVYQKEPHLLQKIWHDRIEAFNSKFQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIA0</accession>
    <name>E9GIA0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_211709</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732546">
        <property type="protein sequence ID" value="EFX80807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80807"/>
    <dbReference type="EnsemblMetazoa" id="EFX80807">
        <property type="protein sequence ID" value="EFX80807"/>
        <property type="gene ID" value="DAPPUDRAFT_211709"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_211709"/>
    <dbReference type="eggNOG" id="KOG0621">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053024_2_1_1"/>
    <dbReference type="InParanoid" id="E9GIA0"/>
    <dbReference type="OMA" id="CCADVKF"/>
    <dbReference type="OrthoDB" id="1015148at2759"/>
    <dbReference type="PhylomeDB" id="E9GIA0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017121">
        <property type="term" value="P:plasma membrane phospholipid scrambling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PTHR23248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="SSF54518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX80807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="273" mass="30714" checksum="3AADFB6B25901492" modified="2011-04-05" version="1">MSHDQQYPVVNQPQAYGAYGAPTSPSPQQHLMGPPQHVGGDQQWMPKPNGGNCPPGLEYLTQVDQILVHQMVEILEMFTGFETNNKYVVKNSVGQKIFFAAEDSGCCERYWCNNLRSFEMNILDNFGNEVIHIHRPLACQSCLYPCCLQKMEVSAPPGNVIGTIEQEWSIFPRFKVKDVSGNVVLKIEGPFFPCSCCGTDVNFEIFSSDGEQKVGKISKQWAGILREMVTDADVFGINFPMDLDVKMKAVLLSACFLIDFMYFEDKQNSRNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9GK97</accession>
    <name>E9GK97_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_103786</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732549">
        <property type="protein sequence ID" value="EFX79949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79949">
        <property type="protein sequence ID" value="EFX79949"/>
        <property type="gene ID" value="DAPPUDRAFT_103786"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_103786"/>
    <dbReference type="eggNOG" id="ENOG502QXFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_633492_0_0_1"/>
    <dbReference type="InParanoid" id="E9GK97"/>
    <dbReference type="OMA" id="EMTHASH"/>
    <dbReference type="OrthoDB" id="976852at2759"/>
    <dbReference type="PhylomeDB" id="E9GK97"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04508">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX79949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="433" mass="49574" checksum="6DA20D53ACF9386F" modified="2011-04-05" version="1">MPIAHLFKDKLVCDIDNQDCMMETIKFQQWESTDRTALAVSELPTDDFLRKLVDMISDLTRHHFVAKKQGKYCRDLKETLKPNECLLQGDYSQKYSMTVQEATQGMFFNAPRQATLHPFLAYLNINGKIVPHSMCVFSDCLNHDAVSVNAFLKPVLQHIKIISPSIDTIKYFSDGAVGQYKNCKNFVNLLRHEEDFNIKYAEWNFFSNSHGKGPCDGIGGTIKRLAYRHSLQGGDIQTPFALFLWAEQQIENLKMFYVSSEDVNGNQKRLEGRLCEARTLTGTQSFHRFVPSLTSKYHMDAYDISENENFKTFQILPIPDPCTSVEFNSISVGKHVACLYSEDGRWYLAIVLEKNKEEQEFLLQFYKPPGESASIRGFKSTTNSKDQAWIPCVDVLKNIDSLEKTSRSGRTFKLSPTEYAQVSKLFTKKMQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GN62</accession>
    <name>E9GN62_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_245351</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732554">
        <property type="protein sequence ID" value="EFX78979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78979">
        <property type="protein sequence ID" value="EFX78979"/>
        <property type="gene ID" value="DAPPUDRAFT_245351"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_245351"/>
    <dbReference type="HOGENOM" id="CLU_875115_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX78979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="318" mass="36210" checksum="DE30262C354D4345" modified="2011-04-05" version="1">MSADIASRERSAESYNKNNSGRDEKKEIRNGVLLVFTYHRRRRMLGQIVRRLVQTSVGRGAARERILVAQRAAAHRRIEAERVAPASAANTTTSSSSCVMAHHRAPVGAQVNVLQHLQNNNNANIWHKSISHLFSKQQEMANPRAIFLLPPTVLLTICSSYAIELRADERDVEYELSNCTGASRAHRGTSIRSNSHANCGLNLILQPQKPSMTPSAPGKNRNYYGLQAKYLAARITLRQEDLEEFSTPPLQPEEEKHYCNPSLRVLLILPKNIRREKKVWRVIPKAIRKTEFIRTGHGTQRNFRQYNHHRLLAEKHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPH7</accession>
    <name>E9GPH7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_320304</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732556">
        <property type="protein sequence ID" value="EFX78674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78674">
        <property type="protein sequence ID" value="EFX78674"/>
        <property type="gene ID" value="DAPPUDRAFT_320304"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_320304"/>
    <dbReference type="eggNOG" id="ENOG502SCYH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_802297_0_0_1"/>
    <dbReference type="InParanoid" id="E9GPH7"/>
    <dbReference type="OrthoDB" id="1114912at2759"/>
    <dbReference type="PhylomeDB" id="E9GPH7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237288" evidence="2">
        <location>
            <begin position="27"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX78674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="346" mass="37785" checksum="68A3CB0E5CFF40B5" modified="2011-04-05" version="1">MASDAYLKCWNAILVFFTCIEPVCQGKQKEAFHFKCNPCSNVEEFVHLGIGNGRDIDQPVASSSSVADDVDQLPASTSRGRGRPRAVMADDVDQLPASTSRGRGRPRAVLADDVDQPPASISRGRGRPRAVLADDVDQLPASTSRGRGRPRAVLAHDVDQPPASLSRGRGRGRNVETPQTPPDSMPAIDQPASYSSRGHGSHTVPPVTTIASLTVNIVLPVSASSPMEDLPLELPIAMNVTCPQDLISPIIAGITYQLRVVETECTYARHLIFATDRQLELLRNAKRWYGDATFDTQVPLVFVLMARKRACDYRVVFTHILDLLMVPPVEEFVMDFEAAVCKFVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQI7</accession>
    <name>E9GQI7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_320584</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
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                <person name="Bork P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Manak J.R."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1994887_0_0_1"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="EFX78042.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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                <person name="Yamagata H."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX77513"/>
        <property type="gene ID" value="DAPPUDRAFT_321432"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033041">
        <property type="term" value="F:sweet taste receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009318">
        <property type="entry name" value="Gustatory_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06151">
        <property type="entry name" value="Trehalose_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX77513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="56" mass="6228" checksum="B51BA508C29A9F3A" modified="2011-04-05" version="1">MTFLIQVDEDFVQFSAAGLFKVVIHLVPALAGAPVTYMVILLQTNSDKKTKQKQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTC3</accession>
    <name>E9GTC3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_321488</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732563">
        <property type="protein sequence ID" value="EFX77254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77254">
        <property type="protein sequence ID" value="EFX77254"/>
        <property type="gene ID" value="DAPPUDRAFT_321488"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_321488"/>
    <dbReference type="HOGENOM" id="CLU_176498_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GTC3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX77254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="94" mass="10751" checksum="45C37B65F6FF5D68" modified="2011-04-05" version="1">MVLSMTQNQQDVFRLKELDAEQKLKERNPEDEVVEEPPVIGESGLSLEVEQTFQEMLKTVKLSDNSILSDRILVPIEEVYQARGFATKANQNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9GVQ8</accession>
    <name>E9GVQ8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_55033</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732568">
        <property type="protein sequence ID" value="EFX76451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76451"/>
    <dbReference type="EnsemblMetazoa" id="EFX76451">
        <property type="protein sequence ID" value="EFX76451"/>
        <property type="gene ID" value="DAPPUDRAFT_55033"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_55033"/>
    <dbReference type="eggNOG" id="KOG3048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091867_0_1_1"/>
    <dbReference type="InParanoid" id="E9GVQ8"/>
    <dbReference type="OMA" id="QAKFKAC"/>
    <dbReference type="OrthoDB" id="1449403at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PTHR12674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00293">
        <property type="entry name" value="TIGR00293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX76451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="152" mass="16959" checksum="FD324F840CC51B39" modified="2011-04-05" version="1">MQKIDLTTLTLPQLSQLKQQLEQDLSLYQDSLQTLKIAQTKFQESAESAEKLESTQEGAPILVPLTGSMYVPGKISKPEQPLIDIGTGYYAENTIEQAKSYFRRKVKFVTEQMEKVQMLGIEKSQVRDAVAEVMDLKVQAQVAANPQAAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GXG5</accession>
    <name>E9GXG5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_249662</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732572">
        <property type="protein sequence ID" value="EFX75939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75939">
        <property type="protein sequence ID" value="EFX75939"/>
        <property type="gene ID" value="DAPPUDRAFT_249662"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_249662"/>
    <dbReference type="HOGENOM" id="CLU_2963124_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="59" mass="6631" checksum="3B2D0773470D60BB" modified="2011-04-05" version="1">MGPAVCKVSSQMCDEQLLSNPEYIQQLWVAPSVIYSLVLFVRPDLREMEWSLHSGGSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYE9</accession>
    <name>E9GYE9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell division control protein 42 homolog</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_306746</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="GL732575">
        <property type="protein sequence ID" value="EFX75374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75374"/>
    <dbReference type="EnsemblMetazoa" id="EFX75374">
        <property type="protein sequence ID" value="EFX75374"/>
        <property type="gene ID" value="DAPPUDRAFT_306746"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306746"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="InParanoid" id="E9GYE9"/>
    <dbReference type="OMA" id="ITHHQQK"/>
    <dbReference type="OrthoDB" id="1091615at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043227">
        <property type="term" value="C:membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032488">
        <property type="term" value="P:Cdc42 protein signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030707">
        <property type="term" value="P:ovarian follicle cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="PTHR24072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX75374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="191" mass="21334" checksum="EF2244E218FA040A" modified="2011-04-05" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCQKTPFLLVGTQIDLRDDAATVEKLAKNKQRVITIDQGEKLARELKAVKYVECSALTQKGLKNVFDEAILAALEPPEPIKKRRCNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYG1</accession>
    <name>E9GYG1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_250385</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732575">
        <property type="protein sequence ID" value="EFX75381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75381">
        <property type="protein sequence ID" value="EFX75381"/>
        <property type="gene ID" value="DAPPUDRAFT_250385"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_250385"/>
    <dbReference type="HOGENOM" id="CLU_3144350_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="49" mass="5393" checksum="65F9DC93EBC178C3" modified="2011-04-05" version="1">MELSKGGKGRGVIDMRPEAHVFGVVTTTTNNVARQDIFRSSGTRFQLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZ30</accession>
    <name>E9GZ30_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_250668</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732576">
        <property type="protein sequence ID" value="EFX75258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75258">
        <property type="protein sequence ID" value="EFX75258"/>
        <property type="gene ID" value="DAPPUDRAFT_250668"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_250668"/>
    <dbReference type="HOGENOM" id="CLU_3034506_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="55" mass="5953" checksum="013678CD4696B482" modified="2011-04-05" version="1">MERCLCFSQRSFPISILDPGKVQRPGGLVFTRPAAAPFEISQVFGKSLVVTGGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZW7</accession>
    <name>E9GZW7_DAPPU</name>
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        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_323833</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="GL732579">
        <property type="protein sequence ID" value="EFX74888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74888"/>
    <dbReference type="EnsemblMetazoa" id="EFX74888">
        <property type="protein sequence ID" value="EFX74888"/>
        <property type="gene ID" value="DAPPUDRAFT_323833"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_323833"/>
    <dbReference type="eggNOG" id="KOG0262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114990_0_0_1"/>
    <dbReference type="InParanoid" id="E9GZW7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="PTHR19376:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb1_3" evidence="8">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX74888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="129" mass="14239" checksum="ED7B354CBAEC54B2" modified="2011-04-05" version="1">MNAHFPQGEVARSEGYNIAAVVPHQYLVPKNGTPLSGLIQDHMIARMKLTMRGQFFNRTDYQQLVFAGLGGREYDGKTKLLSPTIRKPVALWSGKQILSTVIINLTPKGKKLDSSHGLAGSKHGFYSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0F4</accession>
    <name>E9H0F4_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_108525</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX74828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74828">
        <property type="protein sequence ID" value="EFX74828"/>
        <property type="gene ID" value="DAPPUDRAFT_108525"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_108525"/>
    <dbReference type="HOGENOM" id="CLU_1604409_0_0_1"/>
    <dbReference type="OrthoDB" id="1852125at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
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            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="166" mass="17066" checksum="6FE4C1623E314713" modified="2011-04-05" version="1">MNTFKVMIVVCSVMATVCSGQYTQSGKPNSWMNQPANSPLVPNKTGPEDASASIGSPAAPSAPIHINFPASAFPTISQHLCTCTAVSESTAAGMIEKYQQPSSTSAAAAEQQSAPAQQSFSQQQQAPAQSAGSYSTAAAAPIEQGPSAADQFVKPAYTMSNKVTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0N8</accession>
    <name>E9H0N8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
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                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX74680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74680">
        <property type="protein sequence ID" value="EFX74680"/>
        <property type="gene ID" value="DAPPUDRAFT_251557"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_251557"/>
    <dbReference type="HOGENOM" id="CLU_145153_0_0_1"/>
    <dbReference type="InParanoid" id="E9H0N8"/>
    <dbReference type="OMA" id="CATHSNG"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="168" mass="18472" checksum="7BF2B6F4D2CE9219" modified="2011-04-05" version="1">MSSKRKRKDELAARKAKRRATESEVQRFARLEANAVRNAAARSAESEVQRCARLETNAVRNANAREAESEVKLCARLEANAVRNAATRSAESEQQTVNRRAIDALKHASAREAQSELQASARRAADATRHKIAREAECPQQTAARLAASAARFSATISNETQDEATDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9H195</accession>
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        <recommendedName>
            <fullName evidence="2">CDC73_N domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">DAPPUDRAFT_251937</name>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732583">
        <property type="protein sequence ID" value="EFX74456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74456"/>
    <dbReference type="EnsemblMetazoa" id="EFX74456">
        <property type="protein sequence ID" value="EFX74456"/>
        <property type="gene ID" value="DAPPUDRAFT_251937"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_251937"/>
    <dbReference type="eggNOG" id="KOG3786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061264_0_0_1"/>
    <dbReference type="InParanoid" id="E9H195"/>
    <dbReference type="OMA" id="NGETNIC"/>
    <dbReference type="OrthoDB" id="720340at2759"/>
    <dbReference type="PhylomeDB" id="E9H195"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="271"/>
        </location>
    </feature>
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        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX74456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="272" mass="29816" checksum="83EBBCFE2B3C91AB" modified="2011-04-05" version="1">MADPLSLLRQFNVNKKEIIEREGQIIFGEFSWPKTVKTNYLIYGSGKDGAPRDYYTLECLLFLLKNVQLQHPVYVRQAAADSIPVVRRPDRKDLLAYLNGETAASASIDKAAPIEIPIQVRRIAGTAQAGGSGLGSGSGIGGDDNEVPASKKPRLEDQQMQRVKEVLAARLEAPRQDSLINVNKIQSLSEAMSIETIASLKAKRIANKRKTIKGDTEDMGLGLGTSLGLAGSSSSELRGMLDYDFDVTKDILNRERQWRNRTSVLQSSGKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9H1X1</accession>
    <name>E9H1X1_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_307394</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX74293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74293">
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        <property type="gene ID" value="DAPPUDRAFT_307394"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307394"/>
    <dbReference type="HOGENOM" id="CLU_1195916_0_0_1"/>
    <dbReference type="OrthoDB" id="1884109at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
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        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="232" mass="25340" checksum="C6C9D67511873215" modified="2011-04-05" version="1">MKLLVYWCIANFIADFIGVECRSPSVNNLYRNRLSTTISSPTEETSHQQFSTTTPPSLSTVATEKSNDQSLTPLVTQSATPASVKVIPAIVIAPLNSTFPNKTLSTHFNSTKVPITAVPIIDSTPVIRINKTANVTNVSIKHGMNSRFRLNVTNVNRVTVTRPTNASQMFPKRPLLSPTMSRYLAIAKEKALNSTPSSTMPGADKPTHIIAKRAMTMPLLSLDDFVLDVDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9H235</accession>
    <name>E9H235_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX74097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74097">
        <property type="protein sequence ID" value="EFX74097"/>
        <property type="gene ID" value="DAPPUDRAFT_324567"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_324567"/>
    <dbReference type="eggNOG" id="ENOG502TKUM">
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    <dbReference type="HOGENOM" id="CLU_431006_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="431"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX74097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="582" mass="64901" checksum="6D4139F8FEC28B0C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2A4</accession>
    <name>E9H2A4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribokinase</fullName>
            <shortName evidence="10">RK</shortName>
            <ecNumber evidence="3 10">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_231325</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="3 10"/>
    <dbReference type="EMBL" id="GL732585">
        <property type="protein sequence ID" value="EFX74139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74139"/>
    <dbReference type="EnsemblMetazoa" id="EFX74139">
        <property type="protein sequence ID" value="EFX74139"/>
        <property type="gene ID" value="DAPPUDRAFT_231325"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_231325"/>
    <dbReference type="eggNOG" id="KOG2855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_3_1"/>
    <dbReference type="InParanoid" id="E9H2A4"/>
    <dbReference type="OMA" id="IPWRDEL"/>
    <dbReference type="OrthoDB" id="918144at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="12">
        <location>
            <begin position="7"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="226"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="263"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX74139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="318" mass="34334" checksum="7EE9907CFD0C6D7B" modified="2011-04-05" version="1">MVLQEAQIVVLGSFMTDVVSYVSNLPRMGETLCGHKLAICCGGKGANQAVTAARLGAATAIIGKLGNDSFGKSYLDALKKENILTDFIGLTSEALTGLAQIIVEDSGQNSIVIVPGANNYLTTEDVMNSRDTFTKAKIMLSVLEIPRETVLSGLKLANELGVFTILNAAPAVEDLEKNFYILSDIFCVNETEAEMLIKQPVTNHDEALSAAHRLMEKGCKKHVLITLGKNGALLLSRDDNNSFLEPVFVKAPEVKAIDTTGAGDCFLGALAYFLAYYPDWPLCKTVTNSCRVASLSVQRAGTQTSFPYKHELENDLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5C9</accession>
    <name>E9H5C9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_110217</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Dusheyko S."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="98" mass="11186" checksum="7A6553D297F6CF41" modified="2011-04-05" version="1">MTYQTTDIRADKSRNIFRGTTQKTFISCHTVDGLPVAYVLQLARNTTENESEKSRSAFEYQEGFHGAVLNRLAFNTIRFITTGRGEISYGVSKVWWLS</sequence>
</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DAPPUDRAFT_111469"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:DNA replication factor A complex"/>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="302" mass="34638" checksum="AFFA0453B47E1283" modified="2011-04-05" version="1">MLRDSGSESDSDVSGKEVSAEVNEEPVSGQSVVKEVFIDVNKLSPDLRRWKIRGRVCRISRLFPFKGDRNMFYFGLLDSSGLLKVKAFGGDADKYYGIVEEGEMFSIEYARVSVAKNPNNIFPLKFEVILAKESEVERLEQDDTFPRLKVVKYDLKKVRDLPHGTFFDIEVIVYKAGCVVDVRKGELRKLELEVFDASMKPGETVKVTLWNDDIELVSPLDLRKYYYKLSIQDATCNEYLQREYIQTSKASVFKIAKVECDSTESRVVSLWKAKKFKDVGETKRKSDHVPVVTEDEKIRKLV</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="114" mass="13418" checksum="9CBB771925B18521" modified="2011-04-05" version="1">MARYGCQVYAFDPSMDMDHHNHSPGNVHFYNWGLGSRDEYEHHFNWTIHSLSSIYKKLSVRHGRRIIDYLKIDVEYSEWIALPDIIASGMLSNVRQLSMEVHLDKLLSLEQHFA</sequence>
</entry>
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            <fullName evidence="1">Peptidase S1 domain-containing protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732621">
        <property type="protein sequence ID" value="EFX70392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70392"/>
    <dbReference type="EnsemblMetazoa" id="EFX70392">
        <property type="protein sequence ID" value="EFX70392"/>
        <property type="gene ID" value="DAPPUDRAFT_112675"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_112675"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_7_6_1"/>
    <dbReference type="InParanoid" id="E9HCR4"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="PhylomeDB" id="E9HCR4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="17"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="207" mass="23382" checksum="40EDC429E4A2B390" modified="2011-04-05" version="1">MIIKFPLRREFDRRSGILTSARCVLIPGQTLGYLTIYLGAHDITASYEANRRVYNGYEVYIHPEWNPSTQAGDIALIKLYNIVTYTRNYTNNNTGLFQTFKLIAEKDELNRIHPSGLSGILQRAELLQKLPLPNGVQLVTGDNGGPLIFRELNGGRWIQIGIVSFVSSQGFQSGYPYGYTRLRSYSTWVQNVMSSYSGSFGFLRVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9HE07</accession>
    <name>E9HE07_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="4">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PAN3</name>
        <name evidence="6" type="ORF">DAPPUDRAFT_61690</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL732626">
        <property type="protein sequence ID" value="EFX70016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70016"/>
    <dbReference type="EnsemblMetazoa" id="EFX70016">
        <property type="protein sequence ID" value="EFX70016"/>
        <property type="gene ID" value="DAPPUDRAFT_61690"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_61690"/>
    <dbReference type="eggNOG" id="KOG3741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016423_0_1_1"/>
    <dbReference type="InParanoid" id="E9HE07"/>
    <dbReference type="OMA" id="IGPHSQN"/>
    <dbReference type="OrthoDB" id="1515085at2759"/>
    <dbReference type="PhylomeDB" id="E9HE07"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010606">
        <property type="term" value="P:positive regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="PTHR12272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="68"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="4">
        <location>
            <begin position="379"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="340"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="149"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="232"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX70016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="490" mass="54825" checksum="D45105BF46D6D235" modified="2011-04-05" version="1">MYSVYSGPSSFLQSCSGQQRSSFFMNEDIRADLLQRNSVALSISDPALFPDLPTEVDHYHELVPLETHTLNHAVKSNTYGLITSTYKASNSRTGMRYCLKRIHGYRVTSAKCMSMVELWRKVQQCHLVTLREAFTTKAFGDHSIVFAYDYYPGAETLMTKYLASTAPHLDPFSSDPSAPRPYTMQKNRMLQQQAGKGCVLPESLLWSYIIELCSALRSVHSAGLAVRALDPSKVLITSRGRLRLCGGGIFDVLTYDSSSSNITALLPHYQQEDLLALGKLILALACNSLLALQRDNVSTSMDIINKNYSSDLRNLVMYLLSTTQGSRSKNIQEVMPMIGARFFSQLEAATLHADYLEDQLARELDNGRLFRLLGKLGTVVDRPELNLDSTWSETGDRYLLKLFRDYMLHPCTDDGRPWVDLAHIVACLNRLDTASHDKICLTSRDQQNVLVVSYAELHHCLETSFNELQQAALAPSSAHLLLGSSSNNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9HE24</accession>
    <name>E9HE24_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc transporter 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Solute carrier family 30 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DAPPUDRAFT_113099</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732626">
        <property type="protein sequence ID" value="EFX70024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70024"/>
    <dbReference type="EnsemblMetazoa" id="EFX70024">
        <property type="protein sequence ID" value="EFX70024"/>
        <property type="gene ID" value="DAPPUDRAFT_113099"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_113099"/>
    <dbReference type="eggNOG" id="KOG2802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021126_3_1_1"/>
    <dbReference type="InParanoid" id="E9HE24"/>
    <dbReference type="OMA" id="IMVRAIH"/>
    <dbReference type="OrthoDB" id="667718at2759"/>
    <dbReference type="PhylomeDB" id="E9HE24"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EFX70024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="439" mass="48980" checksum="E987A3595D72CCC7" modified="2011-04-05" version="1">MERNFITPVRAMNDFFLKPSDLEILRKTRRRSPYESEPPITVYWLKDVEAKALEVWGSQEALDRERKKKTEELKRYQQYIFSVKRVLKDMRKEPANWSPQGGLMEGSGKVVLTAVAINGCNFLFKMIAWLYTGSHSMFSECLHSLADTVNQLILAYGIHKSSQQSNPDHPYGYSNMRYVASLVSGVGIFCVGAGLSVYHGITGIFNPDPIGSFYWAFFILGGSLVSESATLLVAINSLKKGASKAEMSFWEYVKRGQDPSVNVVLLEDLAAVLGVMVAGSCMAVATHLNSPIPDAIGSLLVGIVLGAVASFIIYSNSAALVGRSIPLSSIQQINSELERDLMIRAVHDVKGIDMGSGLVRYKAEVDFDGRELTRSYLDKQDLEMMLEEVRNMKNINEMEAFMLKHGENIVDLLGAEIDRIENALRKKHPEVRHCDLELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9HE74</accession>
    <name>E9HE74_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS_1_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_189301</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732627">
        <property type="protein sequence ID" value="EFX69966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69966">
        <property type="protein sequence ID" value="EFX69966"/>
        <property type="gene ID" value="DAPPUDRAFT_189301"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_189301"/>
    <dbReference type="eggNOG" id="KOG3762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013133_2_2_1"/>
    <dbReference type="InParanoid" id="E9HE74"/>
    <dbReference type="OMA" id="TGVQCFL"/>
    <dbReference type="OrthoDB" id="453672at2759"/>
    <dbReference type="PhylomeDB" id="E9HE74"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="MFS_1_like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX69966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="572" mass="63912" checksum="953E40FE2ADCDD9F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9HEM2</accession>
    <name>E9HEM2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_328739</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732630">
        <property type="protein sequence ID" value="EFX69780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69780">
        <property type="protein sequence ID" value="EFX69780"/>
        <property type="gene ID" value="DAPPUDRAFT_328739"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_834860_0_0_1"/>
    <dbReference type="InParanoid" id="E9HEM2"/>
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    <dbReference type="PhylomeDB" id="E9HEM2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX69780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="333" mass="37873" checksum="FC9E70F752D51D85" modified="2011-04-05" version="1">MNCSRPKDVSHIIKFNGTNFPLWKLGLFVSLEEQEVLSIVDGTTRIPDEIHRLIPNENDPEAGVLELTNNAEIVAWKKKDVLARRILLSTINLQNTLLGCKTANEIWVRLTSQHLKNAAENKYVVMQRFYHYKFQAAEERHEPAEPSTLSVHPSKPSAQDEPTKNDLLPAISMTIDPVHTIKAGPPLFNHGNESNENNNIEERPTCANRPYPLRTRKPKVWISMKAAETSENFEPQTYQEAIQSKNRHSWKPAILDDYSGLSGSVEVFKPSRASKKSPLPTKLPNPSEGTIPERLLFNPNPLVCQLKASFYVPRLSYFPDLFKRRLSLFSELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9HF33</accession>
    <name>E9HF33_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_5758</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732633">
        <property type="protein sequence ID" value="EFX69621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69621">
        <property type="protein sequence ID" value="EFX69621"/>
        <property type="gene ID" value="DAPPUDRAFT_5758"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_5758"/>
    <dbReference type="HOGENOM" id="CLU_046048_4_0_1"/>
    <dbReference type="InParanoid" id="E9HF33"/>
    <dbReference type="OMA" id="AILGCKF"/>
    <dbReference type="OrthoDB" id="993609at2759"/>
    <dbReference type="PhylomeDB" id="E9HF33"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX69621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="195" mass="21798" checksum="3FFDDC2DA8B5FEAD" modified="2011-04-05" version="1" fragment="single">LLQVQVPTEVERGRSAVLGCRFEMEGDTLYSVKWYKGGKEFFRVVPKDNPPAQTFNVEGVQVNLAASDQNQVVLDNLNLKSEGRYKCEVSAESPNFQTVYDIAEMSIVVPPRDSPVINSPQTVYRIGEEFTANCSSYPSRPPATITWTISDKPVMKEDLIQYPSTLTDGGLEASVVGLHLRLRDAHFDRKGKMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9HFD2</accession>
    <name>E9HFD2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA_cap_enzyme domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_329003</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EMBL" id="GL732635">
        <property type="protein sequence ID" value="EFX69511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69511"/>
    <dbReference type="EnsemblMetazoa" id="EFX69511">
        <property type="protein sequence ID" value="EFX69511"/>
        <property type="gene ID" value="DAPPUDRAFT_329003"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_329003"/>
    <dbReference type="eggNOG" id="KOG2386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021710_1_0_1"/>
    <dbReference type="InParanoid" id="E9HFD2"/>
    <dbReference type="OrthoDB" id="1916106at2759"/>
    <dbReference type="PhylomeDB" id="E9HFD2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA_cap_enzyme" evidence="2">
        <location>
            <begin position="3"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX69511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="298" mass="34345" checksum="8A333114DDD3319C" modified="2011-04-05" version="1">MWPVSLSTKNVQSLASKPYVVGPKPEPKPSGPRFLLYIDSSGDIFLENMTQHIFLVDEDHAIKIETSDGRPITDTVLDGIITREKSINDASSCNGKETTRKLTFVILDAIRCNGNDLTGLNILERIAFVREEILIPSCAGVKKNEAFDLDIVKYEEAYQTENYLSDEYAQRFKYPFRSLMFCPRAKGYKCGTNYDVFQWQEKDIQECSFRLKIPKGIKDLKIAELHAGGPNLSEIKYDTIRLTEEIKTLDGCIIDCRYFEHQWIFIKQRHTTAIIPMEGAQLWRKWQRLKNPFLVIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9HFS9</accession>
    <name>E9HFS9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_62315</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX69417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69417"/>
    <dbReference type="EnsemblMetazoa" id="EFX69417">
        <property type="protein sequence ID" value="EFX69417"/>
        <property type="gene ID" value="DAPPUDRAFT_62315"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_62315"/>
    <dbReference type="eggNOG" id="KOG0094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_22_0_1"/>
    <dbReference type="InParanoid" id="E9HFS9"/>
    <dbReference type="OMA" id="ACQVQKT"/>
    <dbReference type="OrthoDB" id="1048146at2759"/>
    <dbReference type="PhylomeDB" id="E9HFS9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
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    </dbReference>
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        <property type="entry name" value="small_GTP"/>
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    </dbReference>
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        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="240" mass="26753" checksum="817AD587C3608D91" modified="2011-04-05" version="1">MLDKAPNDRQILKLPPAYMPSSTPYAGPDFRPEVKSACISNRLITTGLKISKVIVLGNVAVGKSCLVNRFCHSVFDQNYKATIGVDFEVERFDVLQVPFNLQIWDTAGQERFKCIASSYYRGAHAIVVVFDLTNLYSLSSCPAWLEDALKANTVRPLVFLVGTKRDLLSEAAYKHVEDQATRMARALQAEYWCVSSKLGLNVDRFFNRIAALTFNMSVLQECQEIGQSKEIGSGLVSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGX8</accession>
    <name>E9HGX8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_228840</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732643">
        <property type="protein sequence ID" value="EFX69035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69035">
        <property type="protein sequence ID" value="EFX69035"/>
        <property type="gene ID" value="DAPPUDRAFT_228840"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_228840"/>
    <dbReference type="eggNOG" id="ENOG502QRX5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019533_1_2_1"/>
    <dbReference type="InParanoid" id="E9HGX8"/>
    <dbReference type="OMA" id="KINDECP"/>
    <dbReference type="OrthoDB" id="1209387at2759"/>
    <dbReference type="PhylomeDB" id="E9HGX8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003238127" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="40"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX69035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="353" mass="40393" checksum="D3A80583DCF75ECA" modified="2011-04-05" version="1">MMKLSIFALFALTVCHGFSIDNQARGPILWQDDFESLDTSKWKHLITAWRGGNSEFQYYDNLPENSYVRDGILYIKPTLTADRFGEAFLYNGTLDLYKEGCNVDIDGGCYVVASAEIINPIQSARMVTSDSFSFTNGTIEIRAKMPKGDWIWPAIWMLPTDSVYGEWPRSGEIDIVEIKGNADFSCNGYPIGRQLAGCTLHWGPDPGQNRYPLTHWEKIMQDPDFSSDFHIFRVEWFPNGFQFFIDDEMIGEVYPPPGGFSELGGFGEQNLWSTGTKMAPFDQPFHFVLNVVAGGNFFPDGCQNADYEKPWNAYDPTQMKTFWESRDKWLPTWNADTEDNAMQVDYIRVYELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9HH04</accession>
    <name>E9HH04_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoribonuclease</fullName>
            <ecNumber evidence="6">4.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ERNA</name>
        <name evidence="8" type="ORF">DAPPUDRAFT_347694</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a ribonucleotidyl-ribonucleotide-RNA = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA</text>
            <dbReference type="Rhea" id="RHEA:67796"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ENDOU family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="GL732644">
        <property type="protein sequence ID" value="EFX68974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68974">
        <property type="protein sequence ID" value="EFX68974"/>
        <property type="gene ID" value="DAPPUDRAFT_347694"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_347694"/>
    <dbReference type="eggNOG" id="KOG2849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048034_0_0_1"/>
    <dbReference type="InParanoid" id="E9HH04"/>
    <dbReference type="OMA" id="DTEFKEQ"/>
    <dbReference type="OrthoDB" id="823332at2759"/>
    <dbReference type="PhylomeDB" id="E9HH04"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21159">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039787">
        <property type="entry name" value="ENDOU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037227">
        <property type="entry name" value="EndoU-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018998">
        <property type="entry name" value="EndoU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439">
        <property type="entry name" value="PTHR12439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09412">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142877">
        <property type="entry name" value="SSF142877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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    <sequence length="291" mass="31402" checksum="4AE2D5DEA038F808" modified="2011-04-05" version="1">MKFLALLTVCAIGALQIDAYAVERATVTDAELQALSQQLHIDDVNAVQGIVLNMQSTTTSGSTTDKAPLPLFTSVPADAFSGPTISALLALFDNYDENCKVTEVITAAEQTENDAFLDAILATNVFQQAHEFLVSKGLADADIAVFKEYLRLIWMGQYNRGGGIEGSSGLEHVFLGEKNGNSISGYHGWIKYYRDELAGKINYLGYMTKIDLGVSSVVEMPMSWDGIYKSISSISVSGSPEIELALATVCFLARPNAKCPLLGADGTPYAYQTYTLAYNGNTYVGSAYPTY</sequence>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="59" mass="6637" checksum="22972B2C3A0405E6" modified="2011-04-05" version="1">MERCLSSSHPPCVYYTMEGCTSGECQTWDYISRIPKQQLVSTPNLLAVPELCEGFPVHC</sequence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="198" mass="22278" checksum="EE7A0FD51A7AC7AF" modified="2011-04-05" version="1">MHSSLFTSHTNFSISNQGSQSADSSVTRRRHRRRKLKVFTGDEFPEVYDPTACENYQANMEVNGKRVLLIMLFKSVRQGCSLPYNGLQPYRDVNVFLCCFSITCPLSLENIPTIWKLEVNRRCPNTPIVLVGNKKDLRNDVVTITELEEKGQMPVKAEQAEAVGAEIGAMAYVECSSLMQDGVRNLFQIAAQNGLEVR</sequence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="term" value="F:histone H3-tri/di/monomethyl-lysine-4 demethylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="115"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX68267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="346" mass="40421" checksum="55D83D49A918501D" modified="2011-04-05" version="1">MCLSSDDKSEFFRLSLIDVPENSGFVLTPTQEEMDQFEPYILQTYRNNWEEHGAFIVRPPTKLKHVTLGEFIEAYLKADKAKRGALYSSTTKLKMPFWFAMPHHFKNVLKGYLPNLRRTFRQFLHNPDEIIEGVNVPQIFLGQLGSFLAWHVEDLNLFSINKHHFGEPKHWIAVSYKYTEELRQLFRDQVPHYYDSCEAADWHKGIPVFPQMLIAHSPPIPFHTLKQCAGDYVVTCPSAFHFVLNEGANVAEAMNYPSKEWKFYKNPFKRCTCPRLAGYTAIERKLIFIFLLVSKEDMKKEIAMLKEELEKVKAKKEEIEKALKVEIIGDLNMKKMFSGIIFSIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJ67</accession>
    <name>E9HJ67_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hu li tai shao-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_299616</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732660">
        <property type="protein sequence ID" value="EFX68190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68190"/>
    <dbReference type="EnsemblMetazoa" id="EFX68190">
        <property type="protein sequence ID" value="EFX68190"/>
        <property type="gene ID" value="DAPPUDRAFT_299616"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299616"/>
    <dbReference type="eggNOG" id="KOG3699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_9_2_1"/>
    <dbReference type="InParanoid" id="E9HJ67"/>
    <dbReference type="OMA" id="GWSQSIY"/>
    <dbReference type="OrthoDB" id="400524at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="2">
        <location>
            <begin position="135"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX68190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="482" mass="54135" checksum="2E2A496B44585C5B" modified="2011-04-05" version="1">MAAAEQQLNGLDEQQLNGCEFDPNAVVDEDDLKKLRPPDIDADVRDMERRRRVEVMMGSRTFRDDLERIVDQQLREGGAAGLFALQQHISDLTGMGTHRGLGGGGGGGARCVIPINDIKGVDFPSYVKGEKIIRCKLAALYRLVDLFGWSQSIYNHITVRVSQEQEHFLLNPFGLLYSEVTASSLIKVDMQGNVVDPGTTNFGVNIAGFVLHSAIHAARPDAKCVVHIHHPACVAISALKCGFLPVSQESVLIGEVSYHDYYGILVDPEERESIARNLGPLNKVMFLRNHGLVILGETIEEAFFRACNTVLACESQIRMMPVGLDNLIMISEDAKRRSQFARAGRNNVTLTGVETGEQPEQEEVKEKPRTREVKWRQGDMEFEAYMRMLDNSGYRSGYPYRVHSVRTELPRQKHDVEVPPAVSSFGYLIEEDELYKNSPLRKLLDGRRTLDKNRWINSPNVYQKVEVVEQGTQDPKKITKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJQ8</accession>
    <name>E9HJQ8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_301714</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732664">
        <property type="protein sequence ID" value="EFX68027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68027">
        <property type="protein sequence ID" value="EFX68027"/>
        <property type="gene ID" value="DAPPUDRAFT_301714"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301714"/>
    <dbReference type="HOGENOM" id="CLU_1148201_0_0_1"/>
    <dbReference type="OrthoDB" id="1818035at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX68027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="242" mass="27919" checksum="53D5AA7431D04856" modified="2011-04-05" version="1">MTTIRYSHPAVMVTAFVLLTFIVSKSYIFRGVTAEFYIGEYQTFADHSARNKVKETNPVFHPYDNNMNDDSSGGIDDDDDDESNELIGRSQSEKQSRRHHHHHHHQHRQSSVGRGLSTFNPLTPGGTIYLAFIFLIPLTVGKTGFGQGKSYSKTNGPLERLIHKVQQDQQSLYSEMGYVDGNLVLRRAWRDIRDSLAKKLLWLPWRRRLRDMSDIVASNRNNGTNPSNRKKRKKKYYYKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HL33</accession>
    <name>E9HL33_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_115352</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX67534.1"/>
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    </dbReference>
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        <property type="protein sequence ID" value="EFX67534"/>
        <property type="gene ID" value="DAPPUDRAFT_115352"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1009217_0_0_1"/>
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        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="276" mass="30812" checksum="87366CA3F5386A50" modified="2011-04-05" version="1">MASRMQCIQASLHSSYFCWASVLLGEKIPTTLDTFELEIYLHQEETRKLNDCLDCLDTLVVQEVSVRSSTDENLVDLSLFLNEDKSFNSVVPAGQDKSTIATTEEPENDLPELSPEQLPVDPVALALNHLPAPNEEQTPIISAHFPPPPPPDGDTTVSNLPRQVIEAYLVPVENESFPQISIDDIRQFVFEPTRIRNEHMAVGIDIPKELGDFFEALAGAMTWVSFAIEHWLVLESDSLISKGRVLLSKRLIRRNLAMSDVFRGSQHTIPAPLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9HM89</accession>
    <name>E9HM89_DAPPU</name>
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        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">DAPPUDRAFT_331358</name>
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    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732685">
        <property type="protein sequence ID" value="EFX67101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67101">
        <property type="protein sequence ID" value="EFX67101"/>
        <property type="gene ID" value="DAPPUDRAFT_331358"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1519387_0_0_1"/>
    <dbReference type="InParanoid" id="E9HM89"/>
    <dbReference type="OrthoDB" id="1557430at2759"/>
    <dbReference type="PhylomeDB" id="E9HM89"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein import into peroxisome matrix"/>
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    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="Znf_RING_CS"/>
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    </dbReference>
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        <location>
            <begin position="62"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="177" mass="20711" checksum="87F2A4E2F26FB216" modified="2011-04-05" version="1">MNFIEEINFSPTPSPNHLHICFVCAKISNYVYWKLKKYYMTRNVTVETQINQNAIIFDDGVCAICMGPHDNASRPHCGHTFCFSCLWSWCRIKFACPICQRPVTTIKVERTPNYDDGDDLRFDTPRLFNFNVDQTLLNHEMFEIVCNVIVFVQRFISVWIPCTVWVYSTAWLSGLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HME9</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
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                <person name="Rogozin I.B."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="53"/>
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        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="73" mass="8230" checksum="C85325ECE9E17A5F" modified="2011-04-05" version="1">MIYYRAAVRDQSRETQPADLERVSISRAPVLVPPTANAGPALLFFSRQFDQNRRSNISSPSPPIRRRLLPAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9HMG9</accession>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX67074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="PhylomeDB" id="E9HMG9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
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    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011333">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="85" mass="9847" checksum="374E03F77785A6B1" modified="2011-04-05" version="1">MFQHQTEDYLSEPVEIEDVEPLVFREILHFISTGRLSESEMKSTKPFKILKVAANEVMATEAWEKVERDHPKLCLTTLKKIVETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9HN26</accession>
    <name>E9HN26_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_262479</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732692">
        <property type="protein sequence ID" value="EFX66852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66852">
        <property type="protein sequence ID" value="EFX66852"/>
        <property type="gene ID" value="DAPPUDRAFT_262479"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_262479"/>
    <dbReference type="HOGENOM" id="CLU_1688520_0_0_1"/>
    <dbReference type="InParanoid" id="E9HN26"/>
    <dbReference type="PhylomeDB" id="E9HN26"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003238218" description="FAS1 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="23"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX66852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="156" mass="17355" checksum="6AF851C5BA82FE8D" modified="2011-04-05" version="1">MKPYWVIATLLVASSAIDASPVSPNSVKVMLISANFTALVDSLVANRLDDVLNATGPITIFCPTNEEFKAMMDNKPEMVKGFNGNTTHFKQIMPADIHNDMTVTPFLKDKQLRFNVYGTDKKIMTVNGVMFGEPTVVTLPVVMYKLNKYAKTENYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNI4</accession>
    <name>E9HNI4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein asunder</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cell cycle regulator Mat89Bb</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Set apart in position or space protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DAPPUDRAFT_1338</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the asunder family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732696">
        <property type="protein sequence ID" value="EFX66708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66708"/>
    <dbReference type="EnsemblMetazoa" id="EFX66708">
        <property type="protein sequence ID" value="EFX66708"/>
        <property type="gene ID" value="DAPPUDRAFT_1338"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_1338"/>
    <dbReference type="eggNOG" id="KOG3711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012654_1_0_1"/>
    <dbReference type="InParanoid" id="E9HNI4"/>
    <dbReference type="OMA" id="CMDEAPS"/>
    <dbReference type="OrthoDB" id="676663at2759"/>
    <dbReference type="PhylomeDB" id="E9HNI4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019355">
        <property type="entry name" value="Cell_cycle_regulator_Mat89Bb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955">
        <property type="entry name" value="PTHR12955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10221">
        <property type="entry name" value="DUF2151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0744">Spermatogenesis</keyword>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFX66708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="560" mass="62854" checksum="18637D5898176781" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPH3</accession>
    <name>E9HPH3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_263295</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX66362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="71" mass="7820" checksum="A5A15B79499981E5" modified="2011-04-05" version="1">MLLKNQGSSYMRWPINPLSRSSSPSGDAIRDFILYISQKIGDLPRMMERPQSKDGFGGAGKTAKNNFKGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPT0</accession>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX66257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX66257"/>
        <property type="gene ID" value="DAPPUDRAFT_263453"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_128398_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="12"/>
            <end position="30"/>
        </location>
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    </feature>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX66257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="180" mass="20439" checksum="530D7773766D3197" modified="2011-04-05" version="1">MNQQKTEIVILIWKIVTMIFNLLSQLALVLKKINLPHTMYPTENHQVVVIVKVITLHRVLNSSSTQLLIHGHTIVPCSSKHTLQYQTKPFRMINTLQGPHQIIGTLHSPELLNRYLTEIGRVVNTVPETPLLTQNLQSNTADTVSPLPGRDLPSLESTQQTKKRHRHPEKESFELSVLSP</sequence>
</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX65980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX65980"/>
        <property type="gene ID" value="DAPPUDRAFT_263878"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2887995_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX65980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="63" mass="7200" checksum="DBDCC36001D9AE68" modified="2011-04-05" version="1">MMASVNWEGNIKKGSMQKQGLKQLIGTKAVFDGVRTTTRISNNFELETETKKMRAMPEKPRTR</sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732748">
        <property type="protein sequence ID" value="EFX65363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65363">
        <property type="protein sequence ID" value="EFX65363"/>
        <property type="gene ID" value="DAPPUDRAFT_264788"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_264788"/>
    <dbReference type="HOGENOM" id="CLU_2742601_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="71" mass="7662" checksum="A1D9CB713C340F73" modified="2011-04-05" version="1">MVAAALELAHYLASTIEQQNPPSSSTEEPKSSSRTVREYSLEGGKEDLKTGSSVNNSPGGRELPADRQKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HUK6</accession>
    <name>E9HUK6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_118062</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732812">
        <property type="protein sequence ID" value="EFX64575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64575">
        <property type="protein sequence ID" value="EFX64575"/>
        <property type="gene ID" value="DAPPUDRAFT_118062"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_118062"/>
    <dbReference type="HOGENOM" id="CLU_1788791_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX64575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="145" mass="16407" checksum="E7F2F580F962F6D0" modified="2011-04-05" version="1">MRTLEGVCVYVDYPYPLVLFIAVISKRLHVFEMELRSGNRKGKGKLVIDEKHSQESQESSEEELPDLVNRPPDCFADEGIYHIDDDDEASLGLSFWEKTIIIISSHEMITGKCFVGMSIGTEKREKEKNLTGKRTGFYNAASSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9HUU1</accession>
    <name>E9HUU1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_266298</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732824">
        <property type="protein sequence ID" value="EFX64492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX64492"/>
    <dbReference type="EnsemblMetazoa" id="EFX64492">
        <property type="protein sequence ID" value="EFX64492"/>
        <property type="gene ID" value="DAPPUDRAFT_266298"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_266298"/>
    <dbReference type="eggNOG" id="KOG3659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2500182_0_0_1"/>
    <dbReference type="InParanoid" id="E9HUU1"/>
    <dbReference type="PhylomeDB" id="E9HUU1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX64492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="86" mass="9349" checksum="F4E643F4A3ED297F" modified="2011-04-05" version="1">MAKETNLSGKVKSGLAAADEQQDEDKAQIVFFLSETTAVSAGSHRPDAPNEDSPALEERETWAKKAEFLLAVIGFAVDLGNVWRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9HVF1</accession>
    <name>E9HVF1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cir_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_305123</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732850">
        <property type="protein sequence ID" value="EFX64280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX64280"/>
    <dbReference type="EnsemblMetazoa" id="EFX64280">
        <property type="protein sequence ID" value="EFX64280"/>
        <property type="gene ID" value="DAPPUDRAFT_305123"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305123"/>
    <dbReference type="eggNOG" id="KOG3794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035642_0_0_1"/>
    <dbReference type="InParanoid" id="E9HVF1"/>
    <dbReference type="OMA" id="NIKRKWM"/>
    <dbReference type="OrthoDB" id="1604301at2759"/>
    <dbReference type="PhylomeDB" id="E9HVF1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040014">
        <property type="entry name" value="CIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13151">
        <property type="entry name" value="PTHR13151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cir_N" evidence="3">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX64280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="352" mass="41558" checksum="93121610B04DF8F8" modified="2011-04-05" version="1">MGKGFNNYMCKKFFHPGSRDNLKRVWMAQQKTDAEKKKQEELKAQYEKEQDLYVNKSLVSKESKEKLSVNFLYEPPPGMKKEREKEDGEPEFKFEWQRKYNAPREDYCRGDEDIRDQPFGIAVRNVRCIKCHKWGHVNTDRECLLFNKARDAFDDAIAAADPSEKLMNDMKETGLAMTKSAISTLEQMAVPMQKQLSKSEEEPAAEELTFLKTLSTKEKKKLLKKLEKLEDKEKEKKKKKKRKNEKRENRSPPPLTASSSRVLKLRSRSPLPLTASSSRNERRRSRSPSRLTASSSREDGKGYRKVHQSDGSRSPKRPRNRDRRSRSREKEHREKRRHEESDERMKRKKYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9HW85</accession>
    <name>E9HW85_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_267252</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
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                <person name="Yamagata H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Rogozin I.B."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Zdobnov E.M."/>
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        <source>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1 4">Belongs to the TGF-beta family.</text>
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    <feature type="region of interest" description="Disordered" evidence="5">
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        <source>
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        </source>
    </evidence>
    <sequence length="464" mass="52699" checksum="FC91194A15E4B37E" modified="2011-04-05" version="1">MRRLSAGGVPLLLMCYFLSAALCSSSTTTSTTTSWKSTKRPASSSSSMTGDIGERAEALEGSLLNMFGLKRRPRPGVETRQRIVVPEFLAELYRQQTGLEVDTTNLNLAGKLTQTANTVRTFSHQDADSEIHDDDNSETTGNSILLRFDLASLPAGEALKAGELRLYRSPDGLISWEAERTTNSGRTEDESTDDGHQPERKVTKENKWRRKQQVLIHEVVRPALANGGEPIHRLLDSKIVDVRDEGWMTFDVLPALLRWREQPKRNYGLWLEMKRVNDEALSDIQHFHLRKRPSSSRRKRRSIAVGSPEEETEEEKKQLDQLDLRWASQQPLLVTYSDDGRSRVRSKRAAEKKHKRKGRRDNCRRQSLYVDFNDVGWNDWIVAPPGYHAYYCHGDCPFPLPDHLNTTNHAIVQTLVHSVNPSAVPRACCVPTELSSISMLYIDEYDKVVLKNYHDMVVEACGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUD0</accession>
    <name>E9FUD0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G_PROTEIN_RECEP_F2_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_206426</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88941"/>
    <dbReference type="EnsemblMetazoa" id="EFX88941">
        <property type="protein sequence ID" value="EFX88941"/>
        <property type="gene ID" value="DAPPUDRAFT_206426"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_206426"/>
    <dbReference type="eggNOG" id="KOG4193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002753_3_2_1"/>
    <dbReference type="InParanoid" id="E9FUD0"/>
    <dbReference type="OMA" id="NCWIQND"/>
    <dbReference type="OrthoDB" id="1235710at2759"/>
    <dbReference type="PhylomeDB" id="E9FUD0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F2_4" evidence="6">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX88941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="278" mass="32238" checksum="8A870DCB49343CDD" modified="2011-04-05" version="1">MIGLSLVILTFFLFRKWRKSLGNKILFNFSLALFCVTGCFLCAGLVTFDHRVCKATAASMHYFLLASFAWMVVEGIYQYLQYVLVVGAQNYKSCFMRRASPLAWGLPVLPVLGIFIYDPDLYAIGDEFCWLELEAFYFTVLIPISIMLMFNIFIFIGVLKSVFCIQMRIDLRTSQSVKTRSWYQFRMAICIFFLLGLTWIFGFVSIGDARLVFAYLFCIFNSLQGFAIFAFFVLRERNARKLWFEFARMCSDTKIINSGKTPPNSRSSDYVLKPMSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9FV01</accession>
    <name>E9FV01_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="7">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_304806</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 7">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88811"/>
    <dbReference type="EnsemblMetazoa" id="EFX88811">
        <property type="protein sequence ID" value="EFX88811"/>
        <property type="gene ID" value="DAPPUDRAFT_304806"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304806"/>
    <dbReference type="eggNOG" id="KOG2315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013809_1_0_1"/>
    <dbReference type="InParanoid" id="E9FV01"/>
    <dbReference type="OMA" id="LITWQRP"/>
    <dbReference type="OrthoDB" id="464990at2759"/>
    <dbReference type="PhylomeDB" id="E9FV01"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="PTHR13227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="eIF2A" evidence="9">
        <location>
            <begin position="217"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="465"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX88811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="584" mass="65597" checksum="07BD8D98EA0D72A0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9FVF3</accession>
    <name>E9FVF3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbonyl reductase</fullName>
            <ecNumber evidence="2">1.1.1.184</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CBR1</name>
        <name evidence="2" type="ORF">DAPPUDRAFT_310758</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="EMBL" id="GL732525">
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    <dbReference type="EnsemblMetazoa" id="EFX88544">
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        <property type="gene ID" value="DAPPUDRAFT_310758"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
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    </dbReference>
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    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="256" mass="26832" checksum="E573CDB61F49E6F3" modified="2011-04-05" version="1">MSSTAKKLDGRIAIVTASTDGIGFAVAKRLASDGAQVVVSSRKQKNVDAAVAKLKTEGLTVTGMVCHVGLKEDREKLIEDTVSKFGGLDILISNAAVNPVFGPVLSCPEDAWDKIFDINVKTAFLLAKSAVPHMEKRGRGSIIFISSIAGFQPFSALGAYSVSKTALLGLTKVLAQEVGHSGIRVNCIAPGVIQTKFSAMLVDNDDVRNKVLEGIPLQRIGQPDDMGGLASFLCSDDASFITGENIVAAGGAQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
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    <name>E9FVU5_DAPPU</name>
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            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
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    <gene>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88613"/>
    <dbReference type="EnsemblMetazoa" id="EFX88613">
        <property type="protein sequence ID" value="EFX88613"/>
        <property type="gene ID" value="DAPPUDRAFT_233825"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_233825"/>
    <dbReference type="eggNOG" id="KOG4645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="E9FVU5"/>
    <dbReference type="OMA" id="PYSHLEY"/>
    <dbReference type="OrthoDB" id="55144at2759"/>
    <dbReference type="PhylomeDB" id="E9FVU5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
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        <location>
            <begin position="4"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="289" mass="32722" checksum="35ABEAD43AEE0A92" modified="2011-04-05" version="1">MRMGLNNKRRRQGRFGKVYVAVNNKTGELMAMKEIALQPNDHRTIRSVADELHIFEGIHHPHLVRYYGLEIHREEMIIFMEFCPEGTLEHLVASTETGLPEELIRRFTRQLLEAVTVLHENGIVHRDIKGANIFLTDVGNCLKLGDFGCAAKIKSQTTMFGELQGFVGTQAFMAPEVFMHTMTEGHGRAADIWSVGCVVIEMATGKRPWYELESNYAIMFKVGMGEVPPTPPTLSEEGQAFLSHLLQHDPKQRESAANLLEHNFLKVYQEDDPLYSAVIRHPVSSLSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9FWU7</accession>
    <name>E9FWU7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Salamov A."/>
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                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX87956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87956"/>
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        <property type="family name" value="the membrane attack complex/perforin (macpf) family"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87956">
        <property type="protein sequence ID" value="EFX87956"/>
        <property type="gene ID" value="DAPPUDRAFT_311415"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_311415"/>
    <dbReference type="eggNOG" id="ENOG502QU9D">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="E9FWU7"/>
    <dbReference type="OMA" id="SAPMINA"/>
    <dbReference type="OrthoDB" id="1433145at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX87956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="271" mass="30725" checksum="F03410A67F67F664" modified="2011-04-05" version="1">MDRSVRLHLCRDTEALMIRFLSGFTVDGLSKPWWAFAAAWKKHVLPRIYGVPATYLSDDYIYLLVRIEKRSIVGSINGSMLLEPDLLAKLPSPDAGGKLDAVTKPWRSAVEFFVQFGTHVITDYSAGDALFQVIVYDASSLPLLSEKMLQLRAHVEQFNPVNATKLDWNNLLLKHSTPVHVGKLQLISGNRTLINWLESRLAVSTLPETIPSSIRLLGAPVLFNLFYRQMQPRAVLSMNMAAITKAIPEMSLRTWLDDILINLLRMWEYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYW4</accession>
    <name>E9FYW4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translocon-associated protein subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Signal sequence receptor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_230373</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAP-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87703"/>
    <dbReference type="EnsemblMetazoa" id="EFX87703">
        <property type="protein sequence ID" value="EFX87703"/>
        <property type="gene ID" value="DAPPUDRAFT_230373"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230373"/>
    <dbReference type="eggNOG" id="KOG4490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092935_0_0_1"/>
    <dbReference type="InParanoid" id="E9FYW4"/>
    <dbReference type="OMA" id="TKFTLKH"/>
    <dbReference type="OrthoDB" id="1450535at2759"/>
    <dbReference type="PhylomeDB" id="E9FYW4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009779">
        <property type="entry name" value="SSR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13399">
        <property type="entry name" value="PTHR13399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07074">
        <property type="entry name" value="TRAP-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX87703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="182" mass="20837" checksum="4B186F0C4F475E4A" modified="2011-04-05" version="1">MTQKQKALSKEEEILLQDFSRNVSTKSNALFYGNAFIVSAIPIWLFWRIHFMDLLTSSPLFLIITCLSTYLVSFAYKKTKFVLKHKVAVKREDAISREISKMISEDKKMNKKEKDERVLWKKNEVSDYEATTFSIFYNNAVFLAVVIGLSFFILKSFSPSFNYILSVGLSSGLIALLSTGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZF5</accession>
    <name>E9FZF5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_235928</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87047">
        <property type="protein sequence ID" value="EFX87047"/>
        <property type="gene ID" value="DAPPUDRAFT_235928"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_235928"/>
    <dbReference type="HOGENOM" id="CLU_3144354_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX87047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="49" mass="5498" checksum="46B1A73A0B581CED" modified="2011-04-05" version="1">MENSLVWMMEKQPANEKPTFNAFSAASSVTKTNNSIAFVRHTSNIPVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZS3</accession>
    <name>E9FZS3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein RBM9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RBM9</name>
        <name evidence="5" type="ORF">DAPPUDRAFT_346821</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87214"/>
    <dbReference type="EnsemblMetazoa" id="EFX87214">
        <property type="protein sequence ID" value="EFX87214"/>
        <property type="gene ID" value="DAPPUDRAFT_346821"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_346821"/>
    <dbReference type="eggNOG" id="KOG0125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_491140_0_0_1"/>
    <dbReference type="InParanoid" id="E9FZS3"/>
    <dbReference type="OrthoDB" id="871288at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12407">
        <property type="entry name" value="RRM_FOX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034237">
        <property type="entry name" value="FOX1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="349"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="555" mass="55272" checksum="FB796BEDB6B5AF38" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9G188</accession>
    <name>E9G188_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_307798</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86627">
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        <property type="gene ID" value="DAPPUDRAFT_307798"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307798"/>
    <dbReference type="HOGENOM" id="CLU_2576280_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240514" evidence="1">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX86627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="81" mass="9447" checksum="1B06ABEC98EECEA0" modified="2011-04-05" version="1">MDSTFLVAFFFWLGWAGWDGCPLSLYRTHYYSVGMKRRRMHRSPPPSNCCESPLAHLFSRQERSAELVLYSLRTSLSSLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1A3</accession>
    <name>E9G1A3_DAPPU</name>
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            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
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        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_208134"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG2069">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="COG8"/>
    </dbReference>
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        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="PTHR21311"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="399"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="399" mass="45211" checksum="439A0EF66A70C799" modified="2011-04-05" version="1" fragment="single">MESEDALLKLVFNGDDFKVLPGRLSELNLTTNDASQYLKQISSLGLKNLGKEVNRIAEEKTSIINQTQELAFQEYPTFIETAQCTQDIFQNFQKVNQSTEKLTSGLTNLKEKCLEFSQTAQSLSAARRLTSLALSRHTQLLEILELPQLMDTCVRNGYWEEALELASYVARLERKLGYIPLIVKVAQEVQSCTRLMLSQLIAQLRMPAQLPHCLKVVGYLRRMGVFSEEEIRLKFLQARNSWFKSTLDEIPKEDAYQHVLKTVELSRVHLFDIATQYRAIFTDEDPLVLANQDPNTNESAIYYSWIIQKITDFLGALQCDLPKVSPSSLESVFGQCMYFGLSFGRIGSDFRSLLVPLFSQVVYDRFDHSANKSEAQFAEAMASFSLTRTGSFGSSASYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9G2M9</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX86285">
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        <property type="gene ID" value="DAPPUDRAFT_313375"/>
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    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_313375"/>
    <dbReference type="eggNOG" id="KOG3017">
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    <dbReference type="HOGENOM" id="CLU_035730_2_1_1"/>
    <dbReference type="InParanoid" id="E9G2M9"/>
    <dbReference type="OMA" id="IWNSSYK"/>
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    <dbReference type="PhylomeDB" id="E9G2M9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Pritham E.J."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <location>
            <begin position="84"/>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX86034.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="185" mass="21252" checksum="004E4C074CF3EDD0" modified="2011-04-05" version="1">MNEQVKTLLSWLPFLWDKKEVELESPEKENNLIDFGEQEVNGGPPPFFYNPYQQWHVPSSSHHDGFMPRPPPPSIIPPTSPGSFPNMMDRLEQLENRIEACERETLEFQAQLNEIKVETNDLYQNHSGPANPTEVEMDVYRKELQSNPIMPYTMPYHGNENWSPTCLSPPSATENPFTPYGYGGL</sequence>
</entry>
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    <accession>E9G573</accession>
    <name>E9G573_DAPPU</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.</text>
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    <comment type="similarity">
        <text evidence="3">Belongs to the MnmG family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005739">
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MnmG_N"/>
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    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIDA" evidence="7">
        <location>
            <begin position="40"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA_C" evidence="8">
        <location>
            <begin position="436"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX85424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="671" mass="74666" checksum="74B378D00FC4AAB0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9G597</accession>
    <name>E9G597_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_300203</name>
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    <organism evidence="5">
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </feature>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the CoA-transferase III family.</text>
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        <property type="gene ID" value="DAPPUDRAFT_194168"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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</entry>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Hatcher P."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX84971">
        <property type="protein sequence ID" value="EFX84971"/>
        <property type="gene ID" value="DAPPUDRAFT_34614"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_34614"/>
    <dbReference type="eggNOG" id="KOG3295">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="E9G6K9"/>
    <dbReference type="OMA" id="NQQIPHN"/>
    <dbReference type="OrthoDB" id="1239434at2759"/>
    <dbReference type="PhylomeDB" id="E9G6K9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="InterPro"/>
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        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="203" mass="23545" checksum="69131A6778326016" modified="2011-04-05" version="1" fragment="single">MAPKRNNMIPNGHFHKQWQRYVKTWFNQPARKQRRHAHRVAKARRVFPRPTTSLKPIVRCPTFRYNTRVRAGKGFSLEELRAAKIPKRFAPTIGIAVDHRRRNKSVESLQLNATRLKVYKSKLILFPRNAKKPQKTDATPEEIKLAQQLTTEVMPITRSYKLEKARAITPADRKFSPYAVLRTARTTARLAGIRAKRAKEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6Q1</accession>
    <name>E9G6Q1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Diplostraca</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX85154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85154">
        <property type="protein sequence ID" value="EFX85154"/>
        <property type="gene ID" value="DAPPUDRAFT_99091"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9G6Q1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX85154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="229" mass="25995" checksum="2D6EED9D47E5D2D0" modified="2011-04-05" version="1">MVTKAGNMGMYDPSPATSTCKREGQSQSLEGHGEKRVMQRCRGWVRTDVLHHYQAVNYGVVLLLCCIFDGLVDLVYRCLPAMGNTKPQRRRLTSRQQHTQQSKYYTDAPVHYTTTYAKPQPPAATPSFLLITTPKRSSTTPKRQSTPSYSTRTEAANYYAVPTYNPEAALSYYVDQKYYTDAPIYYTTTYATPSYNTAAAKYYTEEAACYTTTYDAWYTTSRNLSIILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6Y8</accession>
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        <name evidence="4" type="ORF">DAPPUDRAFT_127740</name>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84365"/>
    <dbReference type="EnsemblMetazoa" id="EFX84365">
        <property type="protein sequence ID" value="EFX84365"/>
        <property type="gene ID" value="DAPPUDRAFT_127740"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_127740"/>
    <dbReference type="eggNOG" id="KOG1499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9G6Y8"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035247">
        <property type="term" value="P:peptidyl-arginine omega-N-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
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        <property type="entry name" value="Arg_MeTrfase"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX84365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="355" mass="40833" checksum="78E7DA8F9B078368" modified="2011-04-05" version="1">MDVAAPVVEEKPDAADGTGKPVTEKKEDMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHLFKGKVVLDIGCGTGILSMFAAKAGAARVFGIDCSDIVNQATEIVKANHMDDVISIIKGKVEEVELPEGIEKVDIIISEWMGYCLFYESMLETILHARDKWLKPDGLLFPDRASLYVCAIEDRQYKDDKINWWDEVYGFNMSCIRKVAITEPLVDVVDPKQVVSNSCLLKEVDLYTVTKDELAFSSPFSLQLRRNDYVHALVTFFTIEFTKCHKRMGFSTAPDAPYTHWKQTVFYLDDYLTVKRNEEIFGVFGMKPNAKNNRDLDFNIELNFTGELCTLQENNVYRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7A0</accession>
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    <organism evidence="2">
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        <name type="common">Water flea</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84433">
        <property type="protein sequence ID" value="EFX84433"/>
        <property type="gene ID" value="DAPPUDRAFT_238745"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238745"/>
    <dbReference type="HOGENOM" id="CLU_944165_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX84433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="295" mass="33652" checksum="121F0A1E31C445E9" modified="2011-04-05" version="1">MELLFSTMEIMAIMPRRKGRLLRLQHIMLRLLVTATTSAPYYHAGVIHNCCPVHHYYTEPTYYHTETYYTTIVAYAPRSYYSPPVYTTVAPLLYTTPSPVYYTEPSYYSTEVYTTTYAAPSYYAPPVYCSSLLNHSCSCLYYTEPSYYTTEVYTTVKMKRMWPVIEAEYGWCRNGHNFPDDGIGPPLPPVETDKDSLSLSSMGLIEIRVGMDETGSNDVQSQVAIRFHSGSLAQNSKMTGINLSYSSMPNGSKPVAYNYLAFHDILPNSSETTIRYNYSLTKFRNLATLHYNSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBC3</accession>
    <name>E9GBC3_DAPPU</name>
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        <recommendedName>
            <fullName evidence="6">Glycine cleavage system P protein</fullName>
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        <name evidence="7" type="ORF">DAPPUDRAFT_210308</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Cladocera</taxon>
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            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="6"/>
    <dbReference type="EMBL" id="GL732538">
        <property type="protein sequence ID" value="EFX83183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83183"/>
    <dbReference type="EnsemblMetazoa" id="EFX83183">
        <property type="protein sequence ID" value="EFX83183"/>
        <property type="gene ID" value="DAPPUDRAFT_210308"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_210308"/>
    <dbReference type="eggNOG" id="KOG2040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_3_2_1"/>
    <dbReference type="InParanoid" id="E9GBC3"/>
    <dbReference type="OMA" id="CVPMSEY"/>
    <dbReference type="OrthoDB" id="390348at2759"/>
    <dbReference type="PhylomeDB" id="E9GBC3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
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    </dbReference>
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        <property type="entry name" value="SSF53383"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX83183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="947" mass="104708" checksum="1D82780EEC97B4FB" modified="2011-04-05" version="1"> </sequence>
</entry>
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    <accession>E9GBJ6</accession>
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        <recommendedName>
            <fullName evidence="2">Pep_M12B_propep domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">DAPPUDRAFT_240438</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732538">
        <property type="protein sequence ID" value="EFX83138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83138"/>
    <dbReference type="EnsemblMetazoa" id="EFX83138">
        <property type="protein sequence ID" value="EFX83138"/>
        <property type="gene ID" value="DAPPUDRAFT_240438"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_240438"/>
    <dbReference type="HOGENOM" id="CLU_037555_0_0_1"/>
    <dbReference type="InParanoid" id="E9GBJ6"/>
    <dbReference type="PhylomeDB" id="E9GBJ6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M12B_N"/>
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    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX83138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="366" mass="40726" checksum="7B4EFC4F3C228BFA" modified="2011-04-05" version="1">MPEDPLQRNASPKTKRSGPRENHAHYSFAANGKNYNLTVRPNNFLMAPNMKTVVRSSGEQDKEFVEEHRRGDECHFLHYGNGLVAALSHCTDDDIHGYLIDGGKPMEIKPVPSRLRQMLRSPPETDDEIIMIGAHIVRAVDPFPHLKAHQDSCDAELPMQIKSNITRQSVVMESETIEKRKSNKASTDKSSKNVGKNALEKTIGSKAAAPNKVIELGVFVDSAALSLFMPYLGAREYVKLRELILAFVNAMQALYHLPSLGQRVDLSIVYMEFHAKPPANLVNNGERGQLLDSFCSFQTKLNKPSDSDAEHWDMALLLSGLDLRFDFYAVEKGKNNYVTMGLSTVTGVCTDIYNCVIGEFGVTNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBW3</accession>
    <name>E9GBW3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_100990</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732538">
        <property type="protein sequence ID" value="EFX83086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83086">
        <property type="protein sequence ID" value="EFX83086"/>
        <property type="gene ID" value="DAPPUDRAFT_100990"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_100990"/>
    <dbReference type="HOGENOM" id="CLU_850628_0_0_1"/>
    <dbReference type="InParanoid" id="E9GBW3"/>
    <dbReference type="OrthoDB" id="361612at2759"/>
    <dbReference type="PhylomeDB" id="E9GBW3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="227"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="327" mass="35766" checksum="120797F151E895A1" modified="2011-04-05" version="1">MKNIHGLSERIANRLKEKGFARVEEKIFQAGLLDECTGGKATGHSLGNNNYKNENETESLEKAALYKVVVDSDEDKTLSSLLIKKGAELDKGKCDEMHLASRYAEMKGIVDNLLGTVLHGTTAPNCTSDDNNENMAKEVLEEAFIHSDVEKVRILIEMGADLSKTTWGGGRNALHAASIGAKTTEILDVILATGEFDINVAKNEETTELIDVILDTEQCNINPVDSDGRTPLHYAIKRPDPVTINARRLIKMGADPGIADENGVTPLHMAARNAESMDLIELLLNTEAVDVNCVDKQGQTPLACARDNTHGLADRIIARLREYDDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBY7</accession>
    <name>E9GBY7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_240612</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732538">
        <property type="protein sequence ID" value="EFX83040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83040">
        <property type="protein sequence ID" value="EFX83040"/>
        <property type="gene ID" value="DAPPUDRAFT_240612"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_240612"/>
    <dbReference type="HOGENOM" id="CLU_866723_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GBY7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX83040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="321" mass="36422" checksum="99D08B146EEE143A" modified="2011-04-05" version="1">MVNSLKSSSSPTRHLKKVQTGRIVRGGKPGKPYRRMPAIQERKAFKLGQALYRTVKKYVAPAANAFLLSKGKISAAIDIDFKKLMNVIKKEVKNDPNFVPRLISKTQLEKISMARNDIDHDDFASLYKRSDRHFSVLKNLCECIGNNVAAGEVQRIWYLVKQGDFKSALSFAFRFTTVYDDHVAASLSEIIYGVIDKYLIKAMWAFRDNTEIGDPPIDAYANLKYFINEQSVDVDYLAQGGDARDDKKTLKLCMQARIKNRHGGNRKTFSGWKDDLDVIIRFLRVINDADGAHEVEVIRDKLVAARANNTEVTSEMFTTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9GD31</accession>
    <name>E9GD31_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_302385</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732539">
        <property type="protein sequence ID" value="EFX82665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX82665"/>
    <dbReference type="EnsemblMetazoa" id="EFX82665">
        <property type="protein sequence ID" value="EFX82665"/>
        <property type="gene ID" value="DAPPUDRAFT_302385"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302385"/>
    <dbReference type="eggNOG" id="KOG2475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005871_4_0_1"/>
    <dbReference type="InParanoid" id="E9GD31"/>
    <dbReference type="OMA" id="PWNLANV"/>
    <dbReference type="OrthoDB" id="1309031at2759"/>
    <dbReference type="PhylomeDB" id="E9GD31"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="PTHR10507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX82665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="579" mass="65802" checksum="D5F2828C31D2CB7F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDH7</accession>
    <name>E9GDH7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_241134</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82474">
        <property type="protein sequence ID" value="EFX82474"/>
        <property type="gene ID" value="DAPPUDRAFT_241134"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241134"/>
    <dbReference type="HOGENOM" id="CLU_2851923_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX82474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="65" mass="7133" checksum="727AA53C284D8C58" modified="2011-04-05" version="1">MISSNDLNAESTRKHFTGQVVHGVVANAGLNLNWAPVRLPSATDRYSSEKYSIRDFLSLNSGIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9GE82</accession>
    <name>E9GE82_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_316870</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82360">
        <property type="protein sequence ID" value="EFX82360"/>
        <property type="gene ID" value="DAPPUDRAFT_316870"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_316870"/>
    <dbReference type="HOGENOM" id="CLU_1564476_0_0_1"/>
    <dbReference type="OrthoDB" id="1804820at2759"/>
    <dbReference type="PhylomeDB" id="E9GE82"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX82360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="193" mass="21523" checksum="D8D73CE64B11C9FF" modified="2011-04-05" version="1">MAPLSNEKEMKKWRAVAGLNVILGSIVLIVQVATAFTLGHELIDFIGIGIWGGCFMISAGTLTIRRNPKLISNSICALLSGLSLIISYAWNLGVYNNQEGYYYYCISYGYYDTYTKMCHWRKASDIIFIVCGSLALIVNLFLTMNAEAIVIFPPSVRYPVNNVYDTTNITYMVTSNQHPNGYQQTVYPGAGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEY7</accession>
    <name>E9GEY7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1394 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_128134</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYRI family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732541">
        <property type="protein sequence ID" value="EFX81995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81995"/>
    <dbReference type="EnsemblMetazoa" id="EFX81995">
        <property type="protein sequence ID" value="EFX81995"/>
        <property type="gene ID" value="DAPPUDRAFT_128134"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_128134"/>
    <dbReference type="eggNOG" id="KOG3951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056470_0_0_1"/>
    <dbReference type="InParanoid" id="E9GEY7"/>
    <dbReference type="OMA" id="DAVKMCT"/>
    <dbReference type="OrthoDB" id="1129868at2759"/>
    <dbReference type="PhylomeDB" id="E9GEY7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039789">
        <property type="entry name" value="CYRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009828">
        <property type="entry name" value="CYRIA/CYRIB_Rac1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12422">
        <property type="entry name" value="PTHR12422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07159">
        <property type="entry name" value="DUF1394"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1394" evidence="5">
        <location>
            <begin position="22"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX81995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="337" mass="38439" checksum="DE7141557287DF08" modified="2011-04-05" version="1">MGNLLRLLSREEGTCFSPQRYDLFLDFENAQPTDGEKEMFLEVEAVLKKGQLILNEISQYRGASKEIREAISNPGEDYQEKARDAVFPLVQQLRRYYDFSLDIEKVVPKILSQLCSGSMSPTQHLEKQQALVKQFAEILEFVLKFDEHKMTTPSIQNDFSYYRRIVSRHSLSGSISDEQDLFKTTESDEQISSALASHMSLFYAQPTPMLKVLSEATMKFVADNKDIPVENTTETLSTMASVCQSMLKDPDLIARFMREETYLFVLRVMVGLVILYDHVHPVGAFQKSSNVDVKGCVRVLKEQPSSRSESLLNALRYTTRHLNDESTPKHIKTLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9GFV1</accession>
    <name>E9GFV1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_5648</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732542">
        <property type="protein sequence ID" value="EFX81702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81702">
        <property type="protein sequence ID" value="EFX81702"/>
        <property type="gene ID" value="DAPPUDRAFT_5648"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_5648"/>
    <dbReference type="eggNOG" id="ENOG502QU73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046048_4_0_1"/>
    <dbReference type="InParanoid" id="E9GFV1"/>
    <dbReference type="OMA" id="LRWYIND"/>
    <dbReference type="OrthoDB" id="1717705at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="187" mass="20782" checksum="8BCCD993A50DC0A0" modified="2011-04-05" version="1" fragment="single">LEHVEVPSVVAVGEAAAFLCDVDLEFDNELYSVKWYKDSEEFYEWKPKRTPSVQIYPVEGIQVDRERSVREAVVLRSVTPATAGFFRCEASGEGPAFRSVSGGAALSVVILPKKKPEIFGGYVINEQDGTVELNCTTDPSRPAAQIRWLINNVPVNRELIQETSVSRTSSGLETSFSVLELQSRDHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GGU6</accession>
    <name>E9GGU6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_317746</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Thomas W.K."/>
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                <person name="Geiler-Samerotte K.A."/>
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    </reference>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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    </reference>
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            <begin position="6"/>
            <end position="125"/>
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            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
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        <location>
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            <end position="410"/>
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        <location>
            <begin position="543"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
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        <source>
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    <sequence length="695" mass="80710" checksum="430B801FD05B4846" modified="2011-04-05" version="1"> </sequence>
</entry>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
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    </dbReference>
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            <begin position="1"/>
            <end position="176"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="181" mass="20051" checksum="07CD1B70D8892842" modified="2011-04-05" version="1">MPPEPDALYQMADGLSYIHSRNLVHRDMSTGNVLIAKNDDQVVLLKISDFGFCKPASNTGSFSMSEGSKGTKKYVAPEMLKLMDQRSGGEKPRGNASSDIFSMGCLFFTYLTKGLHPFSDGSIHTIPLNIIDNRQYLESLDERHGYALPFIKGMIQADPETRLGLDKVKEQLLPLLRPSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJU8</accession>
    <name>E9GJU8_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">Myosin regulatory light chain, nonmuscle</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX80175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX80175">
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        <property type="gene ID" value="DAPPUDRAFT_442799"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_442799"/>
    <dbReference type="eggNOG" id="KOG0031">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="PhylomeDB" id="E9GJU8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="C:myosin II complex"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
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    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
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        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX80175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="169" mass="19396" checksum="16F6ED4B7B12339F" modified="2011-04-05" version="1">MDCTGGKCRHVRQLGVVKLLRSVLSEQLQMFLLCLIKPKFKNLRRPMIDQNRDGFVDEEDLHDMLASLGKNPTDEYLEAMMNEAPGPINFTMFLTLFGEKLQGTDPQEVIKNAFGCFDEENTGFLNEERLRELLTLVLSWHQRATSEAMWPKNTSIRIRVSSPIPPDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9GLK0</accession>
    <name>E9GLK0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EOG090X0MUO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EOG090X0MUO</name>
        <name evidence="4" type="ORF">DAPPUDRAFT_304428</name>
    </gene>
    <organism evidence="7">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
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        </lineage>
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    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">PA42</strain>
            <strain evidence="6">TCO</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL732551">
        <property type="protein sequence ID" value="EFX79524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015052">
        <property type="protein sequence ID" value="SVE84671.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015676">
        <property type="protein sequence ID" value="SVE85295.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79524"/>
    <dbReference type="EnsemblMetazoa" id="EFX79524">
        <property type="protein sequence ID" value="EFX79524"/>
        <property type="gene ID" value="DAPPUDRAFT_304428"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304428"/>
    <dbReference type="eggNOG" id="KOG4060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122557_0_0_1"/>
    <dbReference type="OMA" id="LTTYERN"/>
    <dbReference type="OrthoDB" id="1522619at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027487">
        <property type="entry name" value="Ribosomal_L48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13473">
        <property type="entry name" value="PTHR13473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="3">
        <location>
            <begin position="55"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX79524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SVE84671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SVE85295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="185" mass="21246" checksum="4A5B92250953781E" modified="2011-04-05" version="1">MFKLPILGRLIRTVGVAHTELVNVMFSRGLRSNFPAEPEYLDIQGPQVPLYEPLNVQIKSYDYTVLETFSSYIHKTAENLEIEVEDCWATPCQKYKIQTFKPFSTQVDNQYNLNLYERNVQVVDLPTTKAPLFFHVIQAALPEGVRMNVKLHDDTDELLRYVPDLELTQLKSELDALGGPSKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9GLZ1</accession>
    <name>E9GLZ1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chymotrypsin-like protein</fullName>
            <ecNumber evidence="5">3.4.21.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CHY1D</name>
        <name evidence="5" type="ORF">DAPPUDRAFT_347749</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.21.32" evidence="5"/>
    <dbReference type="EMBL" id="GL732551">
        <property type="protein sequence ID" value="EFX79602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79602"/>
    <dbReference type="EnsemblMetazoa" id="EFX79602">
        <property type="protein sequence ID" value="EFX79602"/>
        <property type="gene ID" value="DAPPUDRAFT_347749"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_347749"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_7_6_1"/>
    <dbReference type="InParanoid" id="E9GLZ1"/>
    <dbReference type="OrthoDB" id="1522379at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240455" evidence="3">
        <location>
            <begin position="17"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="67"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX79602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="302" mass="31813" checksum="B0CC9D74A7EC6DA5" modified="2011-04-05" version="1">MKVFAIVFVAIAVAQASGLDLSKYQPRSVLYPRAPVENPNRWVPPKVAPTVDTRGFCGQVQSAPSRIVGGTEATPHSAPWQVAIFIDGQYFCGGTLISNEWVLTAAHCADNAIFFNIYLGSHNVRLTAAEEPTRVEVRSTQYTVHPNWGSIRIINDVALIKLPAPIEFTPEIQPICMAPSTEPDHTGDILHISGWGKPSDAAAGISPVLREVDVPCISNAECAATYGATITAGNICVDTTGGKGSCNGDSGGPLTYVANGVHNQVGVVSFGSSAGCEVGLPAGFSRVSYFAEWISSVTGLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPQ3</accession>
    <name>E9GPQ3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_246138</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732557">
        <property type="protein sequence ID" value="EFX78426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78426">
        <property type="protein sequence ID" value="EFX78426"/>
        <property type="gene ID" value="DAPPUDRAFT_246138"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_246138"/>
    <dbReference type="HOGENOM" id="CLU_1333137_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GPQ3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX78426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="206" mass="23191" checksum="899213D5F84378E9" modified="2011-04-05" version="1">MDVEDDLDFRAPSLDFEILLKCQTKLGSSIGKGVNDVEKVLYKDHQSMLPVFTLLAFLESLELKRNPGKAVKHAFELAGRAFYVVSDFNRKNVLSIMGDNCMQLIENRDVFDVLEHKNLFGALIIDKLLKFGRLLEALVSLDVWARKRSGEREEIRVTWLTCTNISSSRVVGTGLEATKGVPTLRTLVLEAERLVLLTEPGRLISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPZ9</accession>
    <name>E9GPZ9_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_320494</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732557">
        <property type="protein sequence ID" value="EFX78503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78503">
        <property type="protein sequence ID" value="EFX78503"/>
        <property type="gene ID" value="DAPPUDRAFT_320494"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_320494"/>
    <dbReference type="HOGENOM" id="CLU_049793_0_0_1"/>
    <dbReference type="OrthoDB" id="1819820at2759"/>
    <dbReference type="PhylomeDB" id="E9GPZ9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX78503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="446" mass="49754" checksum="F3CE5D0DF4FAF5B3" modified="2011-04-05" version="1">MNSAIEKPLSPKMGFGYHGFGGTSITAVISKHEITQPIAAVNQINHPKEFNISTKMPTGKSNVIQPLPGTKKNLEDLKPKPFRAKPVPLNHYKEPFRPELPSQKYRQRALKEGSHPGLVSRILKPNKPDDEEMAVEPVTKHDITRPIAAVNRINHPKEFNISTKVPTGKSNVIQPLPGTKKNLEDYLKPKPFRARPVPRHHYKEPFRPELPSRKGRQSAPKEETNPGLVSRILHSIVDPILKPNKPEDEEMTVEPAKEEVNSTESDLTVSETDEPTATITEPEVKGFDEQPEGESDGVEDSDDPDVTSTIVSILQSYQEPEMITPIQTLNEPYAFLNSRSDTVDIPDEVEKGEQQSGVNLQEESDVADGVSSADYLKAYLEMMEMVKPRRKPNVIGVTKKQRKKEAGTLPAVNKTPGFGSKAERIRKAQEKKKLKLEKPNAVENPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQ22</accession>
    <name>E9GQ22_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_105297</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732557">
        <property type="protein sequence ID" value="EFX78484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78484">
        <property type="protein sequence ID" value="EFX78484"/>
        <property type="gene ID" value="DAPPUDRAFT_105297"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_105297"/>
    <dbReference type="HOGENOM" id="CLU_1327570_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX78484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="207" mass="22532" checksum="47DC50706E246C6E" modified="2011-04-05" version="1">MQSDQLTVSGCPPELPLPIHFFKAVPPKSPKTASVKGDIRNFFTSIAPKSSKSPGSASNVKDEDAGKRKKKAMVLVDSTDSDSEGPIMKPASLKKTKVEDIPKKETVVSASKLKKNAETPEIPLQPVDIGSVFGNKPIQRSKEIPEKRKRTVIEDHSDEDFEATLQQLAEAPVTKKSKVVEKSTSKKGKPDSPTKKEISCQGKEIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQN3</accession>
    <name>E9GQN3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_320622</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732558">
        <property type="protein sequence ID" value="EFX78143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78143">
        <property type="protein sequence ID" value="EFX78143"/>
        <property type="gene ID" value="DAPPUDRAFT_320622"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_320622"/>
    <dbReference type="HOGENOM" id="CLU_1950948_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GQN3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241390" evidence="3">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX78143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="129" mass="14942" checksum="A1ACF2B85DC591F1" modified="2011-04-05" version="1">MIFKVLSILALVALVFSVTATADPVDEHAVEMEMLKMRAVEMDSRIQQVKAMEDNLRKRHEELDQHTHQLQAEHQKKLQELEALHEDKIKALAGKEREFVEKDEHVKKTASVKKTEKEVEPEEDDHVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9GR13</accession>
    <name>E9GR13_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_320766</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="176" mass="19520" checksum="B48A89EDB0FE18D9" modified="2011-04-05" version="1">MNDYEPDGFAEAIQQQTDEAKTTMMSWTACRGTATKIRSNGMIWADQMREHGHRVDNGRTAKNDRGDGVGRTATQKPATWDDNGRTATQKPARWDDNGRTATQKTGSVEGIGRTAKREHGNTAAKTGNGTESYQAGDDEIMAAGTMGRLSRSMHHKMLDRKLKHKFCRPTLQQSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9GUV4</accession>
    <name>E9GUV4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SPATA6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_322082</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPATA6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732567">
        <property type="protein sequence ID" value="EFX76559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76559">
        <property type="protein sequence ID" value="EFX76559"/>
        <property type="gene ID" value="DAPPUDRAFT_322082"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_322082"/>
    <dbReference type="eggNOG" id="ENOG502S8SR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_698816_0_0_1"/>
    <dbReference type="InParanoid" id="E9GUV4"/>
    <dbReference type="OrthoDB" id="1154886at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097224">
        <property type="term" value="C:sperm connecting piece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032027">
        <property type="term" value="F:myosin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042769">
        <property type="entry name" value="SPATA6_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032732">
        <property type="entry name" value="SPATA6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16435">
        <property type="entry name" value="PTHR16435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14909">
        <property type="entry name" value="SPATA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPATA6" evidence="4">
        <location>
            <begin position="10"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX76559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="395" mass="45732" checksum="32762C58F47E1303" modified="2011-04-05" version="1">MKRTSLKIVFEIKINSVTCPNIRLDPSKWVHLRLSLLGSYLRSRLLKAQFPLQVDEKMRVERTFPLCSTAKHLFSALSGERISIELVQLYQMGSKVLAIFSTDLNDIIFESPYIIREREIRTEQHTMIMHTTHHFPGIANPYVNATITVRLMKVNDTALEISRDGGCNLTLGLKGSENPYYEAPLQEPLPTSHWSENVNPIIRPCQKMAISRSEPQPKIKPIKRQIFCVRHVDDKLICRTPSADPPSHYVDHKTATPNFPAVRSVKSPLHRSTSHMETVSSLMRRKPKISQSFYLWEPESERKYGWGLPDQYQTSECPSQTSTFETLQSHKGRQPTADWEYEDGHFSHSQQDVNESHFSQKRDSNNFWVNHNSEICTLCNLYYDYFGQYYPMHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GV16</accession>
    <name>E9GV16_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_248699</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732567">
        <property type="protein sequence ID" value="EFX76692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76692">
        <property type="protein sequence ID" value="EFX76692"/>
        <property type="gene ID" value="DAPPUDRAFT_248699"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_248699"/>
    <dbReference type="HOGENOM" id="CLU_2778442_0_0_1"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="PhylomeDB" id="E9GV16"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090502">
        <property type="term" value="P:RNA phosphodiester bond hydrolysis, endonucleolytic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX76692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="69" mass="7390" checksum="117CA6B78FF479CE" modified="2011-04-05" version="1">MACRHRTTNLFNSLSSSAPVTSIRAYVDGSKSSCPEITTCAIFVPTLNNEHAWMLTNGSSICIAKVTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9GVI6</accession>
    <name>E9GVI6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BEACH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_306170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732568">
        <property type="protein sequence ID" value="EFX76524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76524"/>
    <dbReference type="EnsemblMetazoa" id="EFX76524">
        <property type="protein sequence ID" value="EFX76524"/>
        <property type="gene ID" value="DAPPUDRAFT_306170"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306170"/>
    <dbReference type="eggNOG" id="KOG1786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001454_0_0_1"/>
    <dbReference type="InParanoid" id="E9GVI6"/>
    <dbReference type="OMA" id="AYEQFTP"/>
    <dbReference type="OrthoDB" id="101142at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035014">
        <property type="term" value="F:phosphatidylinositol 3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043551">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
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        <location>
            <begin position="282"/>
            <end position="558"/>
        </location>
    </feature>
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        <location>
            <begin position="1370"/>
            <end position="1405"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX76524.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1674" mass="185064" checksum="BFE9E922251B8783" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GVK4</accession>
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        <submittedName>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732568">
        <property type="protein sequence ID" value="EFX76426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76426">
        <property type="protein sequence ID" value="EFX76426"/>
        <property type="gene ID" value="DAPPUDRAFT_226030"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_226030"/>
    <dbReference type="HOGENOM" id="CLU_1808161_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX76426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="143" mass="16780" checksum="6F5559394E3B98F5" modified="2011-04-05" version="1">MTTELELAEQEADDFTAMNRQGKRRAREMKNRQDMPSFVMRMEQRSSHEFRDTTGREVHYRDLRWRMTYQTNGVHSKIRDVVYDVLIGGHNRSQYATDGRWTTNHNCVPCTVVKLEGGCVFFLSHHLSTFYDFFARPSAGLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9GWA0</accession>
    <name>E9GWA0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-MWFE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase MWFE subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DAPPUDRAFT_322524</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
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        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX76075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX76075"/>
        <property type="gene ID" value="DAPPUDRAFT_322524"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_322524"/>
    <dbReference type="HOGENOM" id="CLU_185502_1_0_1"/>
    <dbReference type="InParanoid" id="E9GWA0"/>
    <dbReference type="OrthoDB" id="1608843at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005747">
        <property type="term" value="C:mitochondrial respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFX76075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="70" mass="8010" checksum="4E046914A0AE9262" modified="2011-04-05" version="1">MWYEAMTSLLLTTVFVGLPYGIIPLVHKLANNGNAFSRLQNSTHQRFLYRRDTRLTGNPYVLKGLESIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GWN1</accession>
    <name>E9GWN1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_249430</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732570">
        <property type="protein sequence ID" value="EFX76151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76151">
        <property type="protein sequence ID" value="EFX76151"/>
        <property type="gene ID" value="DAPPUDRAFT_249430"/>
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                <person name="Basu M.K."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732575">
        <property type="protein sequence ID" value="EFX75490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75490"/>
    <dbReference type="EnsemblMetazoa" id="EFX75490">
        <property type="protein sequence ID" value="EFX75490"/>
        <property type="gene ID" value="DAPPUDRAFT_306744"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306744"/>
    <dbReference type="eggNOG" id="KOG0912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054449_1_0_1"/>
    <dbReference type="InParanoid" id="E9GYE5"/>
    <dbReference type="OMA" id="IGKLGPC"/>
    <dbReference type="OrthoDB" id="623253at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03072">
        <property type="entry name" value="PDI_b'_ERp44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041862">
        <property type="entry name" value="ERp44_PDI_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240687" description="Thioredoxin domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="29"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX75490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="421" mass="48245" checksum="D678E173F82ADB11" modified="2011-04-05" version="1">MRIFRHVTPLNFVVQFLVLFRLFSHGECGAVQLTADNFDTIIANTELVLINFYADWCRFSNMLAPIFDEAADKVTSEFPSSRVILGKVDCDKDTSIGTRFHISKYPTLKAVRNGQLFKKEYRGQRSAEAFANFVREQLVDPMKEFTQLSEVQHNQMDDKKRHVIGYFETRDSPEYANFAKLAAVLKDDCNFHVGFGEVTRAMHPPGQPIVAFRPAKARSNDMDESFTGDLKSYDEFSIWTTDKCVPLVREITFENAEELTEEGLPFLILFYNPDDNNSIKKYNEIINRELLDEKQNINFLTADGVTFAHPLQHLGKSKKDLPLIAIDSFRHMYLFPKFEDINIPGKLKQFLADLHSGKLHREFHYGPDPATDPPLQLEHHAGNGNSKDDDPSKKPTQPPESTFKKLAPSKNRYTLLDKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZ51</accession>
    <name>E9GZ51_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_323557</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732576">
        <property type="protein sequence ID" value="EFX75269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75269">
        <property type="protein sequence ID" value="EFX75269"/>
        <property type="gene ID" value="DAPPUDRAFT_323557"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_323557"/>
    <dbReference type="HOGENOM" id="CLU_062907_1_0_1"/>
    <dbReference type="InParanoid" id="E9GZ51"/>
    <dbReference type="OMA" id="TEYMESS"/>
    <dbReference type="OrthoDB" id="1384033at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="120"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="263" mass="30094" checksum="276F787C597B96CC" modified="2011-04-05" version="1">MVMNINNQMTTVAEGPLSLTKYILMENTYGDNWSKTPADKYLDSSFCTIEYANEKKLQQDHPCLIQLIRDKYLLQPASKELPYVLDHPETIDPSNGQANDIREILKNKTKGFFVESGGFDGEFLSNTFFMERYLDWNGLLIEADQKSFSKLLSRNRKAFSLPNCISTKPYPIKVLFNVPNNAGGLIVETLEANNNTSKCREDNNESVYTVQCFPFYSILLAVGRTDVDYFGLDVEGSEYKILETIPWHKVNIKVYIDIYSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZ83</accession>
    <name>E9GZ83_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CASPASE_P20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_250757</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732577">
        <property type="protein sequence ID" value="EFX75202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75202">
        <property type="protein sequence ID" value="EFX75202"/>
        <property type="gene ID" value="DAPPUDRAFT_250757"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_250757"/>
    <dbReference type="HOGENOM" id="CLU_1231030_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASPASE_P20" evidence="2">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX75202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="225" mass="26509" checksum="190CBE61D7F128A0" modified="2011-04-05" version="1">MANIDWNETIIEEEEEEELDLLMSQVHDVDVSRLVEEEEEEENRQIPGFNDTPLWVRVQHRKPRKNFQSTGSFRKDPGKLNKTSDSGNNQRTTDNGLFEGLKCPEQLGKPKIFFTNICRAFDVPTDARSRSEEENEGKLKCWIRIIRNFRCLGHNTRKCSIQRSIKEEENYKTLILCTMMTLGNKQVPDNEFFRRQIEEEVAKRVARLDMSTYIRFLIECKDQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9H072</accession>
    <name>E9H072_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_306973</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="gene ID" value="DAPPUDRAFT_306973"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="HCF1/2"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Kelch-typ_b-propeller"/>
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        <location>
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        <location>
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        <location>
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    </feature>
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        <location>
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            <end position="522"/>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0D5</accession>
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        <recommendedName>
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    </protein>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the kindlin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <sequence length="252" mass="27732" checksum="AC70ADD76F8617D9" modified="2011-04-05" version="1" fragment="single">ITFLDYIMGGTKLNCIIAINFTALNGSPNTLGSLHYMGPSPTPYKQALQSVVSIIQDYDSDKQFPVLGFGAKLPPNGILSHEFFVNLTTSPFCAGVEGCVIEAYRKCLPAIQFHGPTNFAPVINHVARFSANYANGDQYFILLILTDGAISDMHDTKEPIRNSRSNLISNLLVEIGNADFSSMNELDSDNVKLSLNGKFASRDIVQFVPFRDFFLNRPDSQNVSQELAKALLAEITAQLLGFMKSKSSFTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5M5</accession>
    <name>E9H5M5_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_307999</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732594">
        <property type="protein sequence ID" value="EFX72891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72891">
        <property type="protein sequence ID" value="EFX72891"/>
        <property type="gene ID" value="DAPPUDRAFT_307999"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307999"/>
    <dbReference type="eggNOG" id="ENOG502QTPV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022631_1_1_1"/>
    <dbReference type="InParanoid" id="E9H5M5"/>
    <dbReference type="OrthoDB" id="1216771at2759"/>
    <dbReference type="PhylomeDB" id="E9H5M5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240854" evidence="1">
        <location>
            <begin position="20"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX72891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="557" mass="59088" checksum="97FB364323A8E591" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9H8A6</accession>
    <name>E9H8A6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_111151</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL732603">
        <property type="protein sequence ID" value="EFX72061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72061">
        <property type="protein sequence ID" value="EFX72061"/>
        <property type="gene ID" value="DAPPUDRAFT_111151"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_111151"/>
    <dbReference type="eggNOG" id="ENOG502RXBE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025643_1_2_1"/>
    <dbReference type="InParanoid" id="E9H8A6"/>
    <dbReference type="OMA" id="HMERVIC"/>
    <dbReference type="OrthoDB" id="1240248at2759"/>
    <dbReference type="PhylomeDB" id="E9H8A6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX72061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="451" mass="51126" checksum="FC9C88ABF0FEC9EC" modified="2011-04-05" version="1">MVWVCCVLGCVNKSGTGIKLFCIPKVNVKYSMSQQQLQKKRRSLWINVINNKTGISDQRICSNHFITGKPNEDESHPDWVPSVKLGTKDALLNDEKTKRDHHRFIRRQKINKTATEAKESTQSRVAAEVVHDDLTSTNPDQEDLDDPDHDTLNLLHSKVKQCEEKLKLLQEELRVTALARDAALKQVDNLIEINDKLLADKHVIVKKLSDLQLHVQNSSIIHQLENDETKTLYYTGLGSFNLLTAIFNALSPGLQEDPRYKISLKEQFILTLMKLRLNLGNRDLGYRFGVAKSTVGCYIEKIITVMHVRLTPALLLWPDKEALMETMPLSFRVHYPKCVAIIDCFEIFCEMHSNIVDKASCYSNYKSHHTAKYMISMTPQGSINFVSKGFGGRSSDVDIVNDSGFLDYIDEGDEVMADRGFLIDEALQIRGATLVMPAFKGRRLQLEGSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9HAT4</accession>
    <name>E9HAT4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_309195</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732613">
        <property type="protein sequence ID" value="EFX71161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71161">
        <property type="protein sequence ID" value="EFX71161"/>
        <property type="gene ID" value="DAPPUDRAFT_309195"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309195"/>
    <dbReference type="HOGENOM" id="CLU_1066589_0_0_1"/>
    <dbReference type="InParanoid" id="E9HAT4"/>
    <dbReference type="PhylomeDB" id="E9HAT4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="261" mass="27948" checksum="C028032621AA7B2D" modified="2011-04-05" version="1">MNNANTIHVMFSPKELKNSKIFNATCKINVPLGLASIFIQLSAMVISVFLDSYIPYGFDDIGFGIWAGISYFMAGSFGMAASSKQRKWRLTTTILVSAFALGASIVSATLSGMAASLGVLPGCENSEYGKSCGPWVGLEWSLMAVSVLAAISSVVLILCASDVLCCGNYSRHNIATTTVSRQQVIHFGNGRQHPQQSGHFKPVAHQQVSLNVQQLPTFQVSYVPQITQHSQPQQVLVTAPVVAPAIAPATVPALQQVQVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9HB55</accession>
    <name>E9HB55_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_256358</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732614">
        <property type="protein sequence ID" value="EFX71027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71027">
        <property type="protein sequence ID" value="EFX71027"/>
        <property type="gene ID" value="DAPPUDRAFT_256358"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_256358"/>
    <dbReference type="HOGENOM" id="CLU_481685_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HB55"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090630">
        <property type="term" value="P:activation of GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX71027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="484" mass="53285" checksum="7FAA2ECA120A1BD6" modified="2011-04-05" version="1">MSRKTDTLCGGTLMNTEQSVDTPPNTNRRRQPCRSVNMGPPVCVCNNEEEQWAQAVGLIHETSSHFVEVQDRKAAWDLLAKCFPIQFFDLLNIPAPYTLQGRQGKETNKARLIQNLPEEAQRELKECEETLKAHADIVEAHKGAARIASKRKALIFSEAELTAKETKLEKERQALNLKRRRTEAEACAVQNNHVSTNPDKGKQLKAPAGISPLLKQVSERLASATGVNVVPVEDFSVNPNVPKRRTRVSRIVPPAQSVIEGLWVPDRGTIRPQLPQGEIDVTKPPFTIDGRILHPVVERIDRAVISQLIDHGLLVPRREVNLEGPQANTSEQAEPSQAEAIGELVRPTSSTGPVTEPASDTDPDDIIIELLKLTTPKKVKIKKEPKPKKTVKASKVKSRVTSTRRTKKTPKTPSLVASEDDLFGSVSEDETTLLASPKAGPSTVPTPEPTSAEPIEVDPVDLEIHPTQADLLGQDAERINFDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9HBJ8</accession>
    <name>E9HBJ8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_217034</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732616">
        <property type="protein sequence ID" value="EFX70903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70903"/>
    <dbReference type="EnsemblMetazoa" id="EFX70903">
        <property type="protein sequence ID" value="EFX70903"/>
        <property type="gene ID" value="DAPPUDRAFT_217034"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_217034"/>
    <dbReference type="eggNOG" id="KOG3033">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048756_2_0_1"/>
    <dbReference type="InParanoid" id="E9HBJ8"/>
    <dbReference type="OMA" id="DWALRWF"/>
    <dbReference type="OrthoDB" id="1361558at2759"/>
    <dbReference type="PhylomeDB" id="E9HBJ8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="288" mass="32294" checksum="2B406A084EB9A88D" modified="2011-04-05" version="1">MEQSFVTVYIVDAFTNELFSGNPAAVCCLENDLPENLKRKIAAEMNLSETAFVTIENGETFEKSSKFALRWFTPTHEVDLCGHATLATAAIIFHKLGNKEKAIEFNTLSGILKAIQENDSSITLDFPLNPSSPYEAQNLKDIIRVVANNFEIQDVQHCSTTQKLLLRLADKYKRKDLEDLNPLTQELLTCESSGVVKGVIVTLQGNENEGYDFYSRYFAPWVGIPEDPVCGSAHTVLAAYWEKVYNKDQFRARQCSKRGGDLNIKIIGQRVKLTGQVAHVLEGKIRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9HC02</accession>
    <name>E9HC02_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_112421</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Cladocera</taxon>
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            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732618">
        <property type="protein sequence ID" value="EFX70745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70745">
        <property type="protein sequence ID" value="EFX70745"/>
        <property type="gene ID" value="DAPPUDRAFT_112421"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_112421"/>
    <dbReference type="HOGENOM" id="CLU_1344502_0_0_1"/>
    <dbReference type="OrthoDB" id="1508073at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="204" mass="22963" checksum="E631ACA467E84D42" modified="2011-04-05" version="1">MVESPSPANTTSSISTEAANEGNYSGSDYTTREESQVQKKMQGEKFTLTWTTDENGFQPRGDHLPVAPVHVYELPVTLPYHRSGAAFCEGRYTPPDGVEWKQFCSTVESNSGTKESYVMDNRVRSSRIVRIRLCPRELGTLKRDTYTEFARIWVVVICGVIDLCPSPKTYGYCMLIVFDDVEALMVRQLLNLKGANDLFLSENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Tsuchiya D."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732654">
        <property type="protein sequence ID" value="EFX68469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68469"/>
    <dbReference type="MEROPS" id="M17.011"/>
    <dbReference type="EnsemblMetazoa" id="EFX68469">
        <property type="protein sequence ID" value="EFX68469"/>
        <property type="gene ID" value="DAPPUDRAFT_301437"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301437"/>
    <dbReference type="eggNOG" id="KOG2597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013734_0_1_1"/>
    <dbReference type="InParanoid" id="E9HIB3"/>
    <dbReference type="OMA" id="GEHPAMP"/>
    <dbReference type="OrthoDB" id="562530at2759"/>
    <dbReference type="PhylomeDB" id="E9HIB3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="5">
        <location>
            <begin position="355"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX68469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="527" mass="56046" checksum="8B6C5AA73D7F638C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJU0</accession>
    <name>E9HJU0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_301721</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732664">
        <property type="protein sequence ID" value="EFX68014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68014"/>
    <dbReference type="EnsemblMetazoa" id="EFX68014">
        <property type="protein sequence ID" value="EFX68014"/>
        <property type="gene ID" value="DAPPUDRAFT_301721"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301721"/>
    <dbReference type="eggNOG" id="KOG1065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008294_1_0_1"/>
    <dbReference type="InParanoid" id="E9HJU0"/>
    <dbReference type="OMA" id="FQWQDSQ"/>
    <dbReference type="OrthoDB" id="238940at2759"/>
    <dbReference type="PhylomeDB" id="E9HJU0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX68014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="801" mass="90166" checksum="5B640DACA4B5B743" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKP8</accession>
    <name>E9HKP8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_261210</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732670">
        <property type="protein sequence ID" value="EFX67700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67700">
        <property type="protein sequence ID" value="EFX67700"/>
        <property type="gene ID" value="DAPPUDRAFT_261210"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_261210"/>
    <dbReference type="HOGENOM" id="CLU_2322707_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="99" mass="11425" checksum="BD758FAC7288E49C" modified="2011-04-05" version="1">MPSPYLERRDMRGGDLRENRDMMHYPGASVRRLNINDVNRKPWYDESRHPNDSGSSAAERVSAMTAAQSVERTQPMFDNRSVNEDVYFDLIEQEKFAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKQ2</accession>
    <name>E9HKQ2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_115242</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732670">
        <property type="protein sequence ID" value="EFX67697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67697">
        <property type="protein sequence ID" value="EFX67697"/>
        <property type="gene ID" value="DAPPUDRAFT_115242"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_115242"/>
    <dbReference type="HOGENOM" id="CLU_1847125_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="PTHR45797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX67697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="139" mass="16258" checksum="6795319050C1037F" modified="2011-04-05" version="1">MYNYVDHMDVDRMDVNEIDGDRPAYQDLLRDVRIEPEQQEDVTMEVDNHEDDSMVKRVLVVCPSGSILNWFDKFKLSLPKEPGFKVYQMAGVKHNSKDHKNDIRLPMLKTWHDDGGVMIIGSDMLGNLTNPKYKKIEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLN0</accession>
    <name>E9HLN0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_302027</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732679">
        <property type="protein sequence ID" value="EFX67386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67386"/>
    <dbReference type="EnsemblMetazoa" id="EFX67386">
        <property type="protein sequence ID" value="EFX67386"/>
        <property type="gene ID" value="DAPPUDRAFT_302027"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302027"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_4_0_1"/>
    <dbReference type="InParanoid" id="E9HLN0"/>
    <dbReference type="OMA" id="ARMMSTG"/>
    <dbReference type="OrthoDB" id="1564596at2759"/>
    <dbReference type="PhylomeDB" id="E9HLN0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="Histone_H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="PTHR11426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone" evidence="2">
        <location>
            <begin position="33"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX67386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="146" mass="16693" checksum="2CCAC1CC1051A680" modified="2011-04-05" version="1">MVREKQTARKSTRAAGQLTALAAQKKIKGRHSQRIANQSGLKTELLKKKKHLHHYRPGALALKEIRRYQNSTNLLIPRVRFQRLVREISKDFKLNLRFQSGAIGTLQEASEAFLVGLFEDTNLCALHANRVTIMPKDIQLARRIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HM92</accession>
    <name>E9HM92_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_302209</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732685">
        <property type="protein sequence ID" value="EFX67145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67145">
        <property type="protein sequence ID" value="EFX67145"/>
        <property type="gene ID" value="DAPPUDRAFT_302209"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302209"/>
    <dbReference type="HOGENOM" id="CLU_1940194_0_0_1"/>
    <dbReference type="InParanoid" id="E9HM92"/>
    <dbReference type="OrthoDB" id="1783124at2759"/>
    <dbReference type="PhylomeDB" id="E9HM92"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NPL" evidence="1">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="130" mass="14813" checksum="641FEA0DF2E1CA17" modified="2011-04-05" version="1">MSCLNTCSPKSFWSMVIKPKNKYSFTVERSFHISKAVIDFSSRPRDNYGVYLHSAMTSLVVDCGDQKGIILCNLGNQETKKMLRPEADLDVHFQTGQEITLYSVKLHPDESTNNLYQTLTIHLSGYEFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HMJ9</accession>
    <name>E9HMJ9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_331466</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732687">
        <property type="protein sequence ID" value="EFX67044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX67044"/>
        <property type="gene ID" value="DAPPUDRAFT_331466"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_331466"/>
    <dbReference type="HOGENOM" id="CLU_2239256_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="105" mass="12248" checksum="0D6D6111A9839B86" modified="2011-04-05" version="1">MHLDTGKVNYTWNVPQNFLMTASELNSFYRSLLKNELLENCEDQYGQPCVLGEKDETFHRAMFSPDLTTGGDIGVFLVDKGVFHQVKKHRMYRIVPEFITFQALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HN07</accession>
    <name>E9HN07_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_262450</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732692">
        <property type="protein sequence ID" value="EFX66845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66845">
        <property type="protein sequence ID" value="EFX66845"/>
        <property type="gene ID" value="DAPPUDRAFT_262450"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_262450"/>
    <dbReference type="HOGENOM" id="CLU_2361831_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX66845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="98" mass="11055" checksum="2A2EA5A47B8C284D" modified="2011-04-05" version="1">MNNENAKRPQYDFCRHRGFISTIGEDVCWRKEAYLEGKKEAAAGSALTVKSSSNNNNSESKTTVKTIMLSLQVSQFLHKNIGMLTQVLDMFEYGLKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNA5</accession>
    <name>E9HNA5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_331737</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732695">
        <property type="protein sequence ID" value="EFX66724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66724">
        <property type="protein sequence ID" value="EFX66724"/>
        <property type="gene ID" value="DAPPUDRAFT_331737"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_331737"/>
    <dbReference type="HOGENOM" id="CLU_957312_0_0_1"/>
    <dbReference type="InParanoid" id="E9HNA5"/>
    <dbReference type="OrthoDB" id="1442007at2759"/>
    <dbReference type="PhylomeDB" id="E9HNA5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003238223" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="53"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX66724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="291" mass="32904" checksum="DE048E0C6B2D7DA3" modified="2011-04-05" version="1">MRSSYFFKVFLLATAVAVCQTGIVSANSLGKVETKAACPGFLQGNTAVPCWPLNGKCYCFSKTNRVTWLDADKFCRIGGMTLLSLESKEEDQMINNHIKSTSEFSDDYYWISGKFSNNRWEWANNEPLTYTHWYTGEPSYNQSGSFVYINYLFPNGIWFDQIGPAYILFICESIDEETTTVDTQTTEKEVPTEPTTEAVEPTTTKATITIEPVSTTTEESLETTARPEEITTEFSKTTTTAGETTPTPFFCPKYLQGNISMPCWTLTDKCYCFSKFVSVVLEHLHIFYRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNW3</accession>
    <name>E9HNW3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_331956</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732699">
        <property type="protein sequence ID" value="EFX66579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66579"/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX66176.1"/>
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        </source>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Kultz D."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the SEC6 family.</text>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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    <name>E9HS54_DAPPU</name>
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        <recommendedName>
            <fullName evidence="2">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Dong Q."/>
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                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="206" mass="23115" checksum="5684D482B050E3FC" modified="2011-04-05" version="1">MEVDEQPTLSVNEQIEAAAASGAAAAAADEAAYNLRPRPRLPDADDAAFLLASRSNTIIHAMELLQEPPSQSYPQSRSAFTCVREIIIDMPAEPAQPEENIEVEDVEVEIIAEKIISEWRQLHQNLMHTSPASPDERRKEEEEPTQGPALPPIRMKKRSAYTTDQEVEEIMKHQGSWDIVDPQPAEKKSKLHYLKSLKSMSLLRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9HWR6</accession>
    <name>E9HWR6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_66718</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="GL732955">
        <property type="protein sequence ID" value="EFX63814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63814">
        <property type="protein sequence ID" value="EFX63814"/>
        <property type="gene ID" value="DAPPUDRAFT_66718"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_66718"/>
    <dbReference type="eggNOG" id="KOG0261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084021_1_0_1"/>
    <dbReference type="InParanoid" id="E9HWR6"/>
    <dbReference type="OrthoDB" id="591636at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb1_1" evidence="8">
        <location>
            <begin position="13"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX63814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="116" mass="12926" checksum="D2F108CBAB51EE80" modified="2011-04-05" version="1" fragment="single">MSKEQYRDTDVIRKIAKVSFGIESPQQIQQNSHIQIVSEKLYLENSSSNQDSSRTPVPNGMLDRKMGTSVKDALCATCGKGVENCVGHFGYIDLELPVFHVGYFKATINVLQTICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HYX7</accession>
    <name>E9HYX7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_269150</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733238">
        <property type="protein sequence ID" value="EFX63055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63055">
        <property type="protein sequence ID" value="EFX63055"/>
        <property type="gene ID" value="DAPPUDRAFT_269150"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_269150"/>
    <dbReference type="HOGENOM" id="CLU_2308849_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HYX7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX63055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="100" mass="11549" checksum="59B56DC660B0AF88" modified="2011-04-05" version="1">MAFNLTAQEKAEIFKVTCSEKCLIHLQKYFETHYGLVDLERYRALYWEAIAEDGVVGMGPGKFRKWLSRNPELAELTNLEISLVARNVEWTLAQQQTQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZA2</accession>
    <name>E9HZA2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endostatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_15160</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733299">
        <property type="protein sequence ID" value="EFX62931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX62931"/>
    <dbReference type="EnsemblMetazoa" id="EFX62931">
        <property type="protein sequence ID" value="EFX62931"/>
        <property type="gene ID" value="DAPPUDRAFT_15160"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_15160"/>
    <dbReference type="eggNOG" id="KOG3546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123121_0_0_1"/>
    <dbReference type="InParanoid" id="E9HZA2"/>
    <dbReference type="OMA" id="IFTDDTW"/>
    <dbReference type="OrthoDB" id="1362001at2759"/>
    <dbReference type="PhylomeDB" id="E9HZA2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010515">
        <property type="entry name" value="Collagenase_NC10/endostatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06482">
        <property type="entry name" value="Endostatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endostatin" evidence="1">
        <location>
            <begin position="2"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX62931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="181" mass="20192" checksum="12BDDB92BCD658F7" modified="2011-04-05" version="1" fragment="single">QLRLVALNEPLSGDMGGIQRVDYACFRQARPAGLRGTFRAFLASRVQNLDTIVRSSDREFPVVNLRGEVLFRTWNDLFRGGRASKFASAARQQRHDIYSFNNRNIFNDIVWPQKVVWHGAGPSGERQLDSYCDAWTAASLIASSPSSHQQQQQTGGGGGKLLAQDKFSCQNRFVVLCIEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9I037</accession>
    <name>E9I037_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_120024</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733464">
        <property type="protein sequence ID" value="EFX62643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62643">
        <property type="protein sequence ID" value="EFX62643"/>
        <property type="gene ID" value="DAPPUDRAFT_120024"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_120024"/>
    <dbReference type="HOGENOM" id="CLU_940932_0_0_1"/>
    <dbReference type="InParanoid" id="E9I037"/>
    <dbReference type="PhylomeDB" id="E9I037"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX62643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="296" mass="34325" checksum="0482E89E84EB5863" modified="2011-04-05" version="1">MESVGLIHRDADLLQFVDVYLQNPDSACIQARYFTASPRCIIADGTMRSYLKRTKGHTGYRSCNRCIQKEEMINLAILLRSVNTPRRTDVNFLTYHTNSLSGDEHLKDIRDVNPFVKIDFPMVTGFIIDPMHTGIEGAFSRRFEGFILVPEEGKLSSSKIDEADRRIKFFRLCRPFGFDRYEGKFSTCKNCKIHVKRNILYYLLYPLFQGIFDETNLEHIMLLQYGMLLLGAFNKEPVSRTNIIEAQKTFQRYSVDLTELGIPCRFVSHQVTHLWEDVEKYGCGVKAKRVFLSKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9I0W4</accession>
    <name>E9I0W4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_270542</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL733643">
        <property type="protein sequence ID" value="EFX62365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX62365"/>
    <dbReference type="EnsemblMetazoa" id="EFX62365">
        <property type="protein sequence ID" value="EFX62365"/>
        <property type="gene ID" value="DAPPUDRAFT_270542"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_270542"/>
    <dbReference type="eggNOG" id="KOG1651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1338756_0_0_1"/>
    <dbReference type="InParanoid" id="E9I0W4"/>
    <dbReference type="OMA" id="CHCNDTI"/>
    <dbReference type="OrthoDB" id="1483113at2759"/>
    <dbReference type="PhylomeDB" id="E9I0W4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003238633" description="Glutathione peroxidase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX62365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="205" mass="23590" checksum="1B3662E895FE8723" modified="2011-04-05" version="1">MVAAAAQMMSAFSVVLLTLMLWGRQTFAEDDVVIELPKSQPCHCNDTIFRFSEKLLTKDTDIRLSSFRNRNGKQKYIELNALQEELADNLAILAFPCNQFGKQEPGGSDLEVLNGIRYVRPGNNFQPQMKLFKKIDVNGDNEHPLFSYLKSCCPPTRDYFQEATKLYYTKIRVNDIRWNFEKFLVNRQGVPVMRYDASANVTWGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9I1U5</accession>
    <name>E9I1U5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_337578</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733880">
        <property type="protein sequence ID" value="EFX62036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62036">
        <property type="protein sequence ID" value="EFX62036"/>
        <property type="gene ID" value="DAPPUDRAFT_337578"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_337578"/>
    <dbReference type="HOGENOM" id="CLU_1373469_0_0_1"/>
    <dbReference type="OrthoDB" id="571786at2759"/>
    <dbReference type="PhylomeDB" id="E9I1U5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="SSF90209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="199" mass="23058" checksum="D47D5426AAE87EE9" modified="2011-04-05" version="1">MDKVSPNDWQCSRPGCSFLNFAKRTVCRECGKSRKPGLYDNPLDIARDSALFWSKGEEEDFLPTVNSPPQQEQDDLYLVFEKHRVDAESKQHLEMDILQKDPIIKTIGQGQKRKKLQPHLKKKKIEKLNAKKTQKQEDLKREKNNFASVTCNELLAEAILLDPTDEMLPVNVRAEFDAEKNIKEEQEEMSDYFSDISLD</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_120729"/>
    </dbReference>
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    </feature>
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            <end position="129"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502RYW1">
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    <dbReference type="InParanoid" id="E9I2D5"/>
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    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="278" mass="31259" checksum="7B010030B1A03588" modified="2011-04-05" version="1" fragment="single">MSNTVLDVKENSFVQHIADNADHDTCTFDGKGTFHAMAIIAAVTPGSKKTKCCVPRREVKDEAIRAAGKIPIIPHTIDESVLGKISYQHLNWERFQDNEKYFDQLWLVSWFLKQPRPGWHGSMQNAMMARNHPGKAEIVFLPIIDMPASNDTTINSTLKLIVCQAKKYGLTPKVTFDQQLWWKAMQIIENASLQCLYREMICKLGGVHTMGSFLACIGHLMDGSGLHELIDLIYAANTTPHILRGKAISRAIRAHIIVEYALHIVLHEEQLSNDSEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2E1</accession>
    <name>E9I2E1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ThiF domain-containing protein</fullName>
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    <organism evidence="4">
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        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_68601"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_68601"/>
    <dbReference type="eggNOG" id="KOG2012">
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    </dbReference>
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    <dbReference type="OMA" id="LGHEATR"/>
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    <dbReference type="PhylomeDB" id="E9I2E1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="2">
        <location>
            <begin position="60"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX61839.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
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</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="91" mass="10496" checksum="BC252FA790A16DED" modified="2011-04-05" version="1" fragment="single">RIDFKIALLTYRCLNCLAPRYLSSLLRLPVSSRLACDRLISMKSRTNTYGCRSFKTYAPQLWNSLPQNVRIASSLAQFRSRLKTHLITVAF</sequence>
</entry>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wolf Y.I."/>
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                <person name="Crease T.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_200702_0_0_1"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL737514">
        <property type="protein sequence ID" value="EFX59932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX59932"/>
        <property type="gene ID" value="DAPPUDRAFT_280290"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_280290"/>
    <dbReference type="HOGENOM" id="CLU_2887984_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX59932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="63" mass="6773" checksum="7BC4D344D96D0E90" modified="2011-04-05" version="1">MPWKNSGGGSGAISVPSDLEFADATLPLCEAKRNTFFDDNPGRRVDKVRVILKPTGASIVLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSZ2</accession>
    <name>E9FSZ2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_220418</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the scoloptoxin-05 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89276">
        <property type="protein sequence ID" value="EFX89276"/>
        <property type="gene ID" value="DAPPUDRAFT_220418"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_220418"/>
    <dbReference type="HOGENOM" id="CLU_1462748_0_0_1"/>
    <dbReference type="OMA" id="EGRENEM"/>
    <dbReference type="OrthoDB" id="1771225at2759"/>
    <dbReference type="PhylomeDB" id="E9FSZ2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="SSF57302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236349" description="UPAR/Ly6 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="3">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX89276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="185" mass="19115" checksum="3F329A93F0464A6F" modified="2011-04-05" version="1">MNSSLVIIVAMLAVTISTVSGLQCYSCEGRENEMCGNNPTRANRITCATNEMCNILRTERSDFSGRTVTFSRGCRQSAFAGAVGGNGVGVSTSSQSCSTDLCNTGDGLGASINFPGFNSNGFGFNTNTNNNNNGFGGFASGGGGGFNNDFNRQPGNDAPAGTKTNYNPLMLPFLGLVSSILGNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9FTM4</accession>
    <name>E9FTM4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_230174</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89389"/>
    <dbReference type="MEROPS" id="S01.123"/>
    <dbReference type="EnsemblMetazoa" id="EFX89389">
        <property type="protein sequence ID" value="EFX89389"/>
        <property type="gene ID" value="DAPPUDRAFT_230174"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230174"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_7_6_1"/>
    <dbReference type="InParanoid" id="E9FTM4"/>
    <dbReference type="OMA" id="PWISSIT"/>
    <dbReference type="OrthoDB" id="1522379at2759"/>
    <dbReference type="PhylomeDB" id="E9FTM4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240544" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="74"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX89389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="311" mass="33230" checksum="9DB3DE6C0815C750" modified="2011-04-05" version="1">MKVILCLAICVFAQSMGQVLLPIERNWSKIEEKWADPTAPRHIPRAEEIPLRHKATRESKDFRAACGVANPARIINGAEATPNEFPWVAALFISGGSFCTASLISDQWILTAAHCADGALYFDVYLGAHNVRVTEPTRLEIRATEKYINPNWNPNTLNGDVALIKLPAPVDISGDLVRPICLQDPTDTDLYVGASAKIAGWGKTADGPGGISPTLQKSTVTVITNAECQNTYGALIIRDYTICTSFTDTNSGTCNGDSGSAMSVINANGQYTQIGVTSFVSSAGCASGNPDGYARVSSYLPWISSITGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9FTZ0</accession>
    <name>E9FTZ0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_24221</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89557"/>
    <dbReference type="EnsemblMetazoa" id="EFX89557">
        <property type="protein sequence ID" value="EFX89557"/>
        <property type="gene ID" value="DAPPUDRAFT_24221"/>
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    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_24221"/>
    <dbReference type="eggNOG" id="KOG0117">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_022960_4_0_1"/>
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    <dbReference type="OMA" id="HTEINGT"/>
    <dbReference type="OrthoDB" id="1384330at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0003723">
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006535">
        <property type="entry name" value="HnRNP_R/Q_splicing_fac"/>
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    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
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    <dbReference type="Pfam" id="PF00076">
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    </dbReference>
    <dbReference type="SMART" id="SM00360">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SSF54928"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01648">
        <property type="entry name" value="hnRNP-R-Q"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="42"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="122"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="217"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX89557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="290" mass="33624" checksum="C9530607DF889B97" modified="2011-04-05" version="1" fragment="single">KREESLMKLMQETGCEIIQENGQRKFGGPPPNWEGPPPPKGTEIFVGKLPRDVFEDELYRIFSTIGPIYELRLMMDFSGSNRGFAFIQFAHRQDANRAIQLMDNYELRPRHHIGVVKSIDNCRLFIGGIPKTKSREEIQGEMERLTEGVTKVIVYSSITDKTKNRGFAFVEYINHRAASKARRKLIPDRIQLWGKEIAVDWAEPENEIEEDVMSQVTVLYVRNLSLTTTEQVLRELFNRVSDDNVQKLKMMRDFAFIHFSSREKAEKAMRNMNHTEINGTTIEITWAKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9FV28</accession>
    <name>E9FV28_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative stromalin antigen protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_347500</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88483"/>
    <dbReference type="EnsemblMetazoa" id="EFX88483">
        <property type="protein sequence ID" value="EFX88483"/>
        <property type="gene ID" value="DAPPUDRAFT_347500"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_347500"/>
    <dbReference type="eggNOG" id="KOG2011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005067_0_0_1"/>
    <dbReference type="InParanoid" id="E9FV28"/>
    <dbReference type="OMA" id="LDWSTMV"/>
    <dbReference type="OrthoDB" id="167826at2759"/>
    <dbReference type="PhylomeDB" id="E9FV28"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="3">
        <location>
            <begin position="244"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX88483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="850" mass="97264" checksum="851AF6875758F2C3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9FV37</accession>
    <name>E9FV37_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_310669</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88488"/>
    <dbReference type="EnsemblMetazoa" id="EFX88488">
        <property type="protein sequence ID" value="EFX88488"/>
        <property type="gene ID" value="DAPPUDRAFT_310669"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_310669"/>
    <dbReference type="eggNOG" id="KOG3215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2742643_0_0_1"/>
    <dbReference type="OrthoDB" id="1394258at2759"/>
    <dbReference type="PhylomeDB" id="E9FV37"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="71" mass="8247" checksum="6D54403638B45F1D" modified="2011-04-05" version="1">MEYDALAAIIQTQPDRKSTQEKLSLLRQVLEASECECQKLEARLKQRRKQFHLLISTFQGLQQLLNDDEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9FVK8</accession>
    <name>E9FVK8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PLAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_191054</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="603" mass="66206" checksum="EC9BDAC793934175" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
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                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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                <person name="Yamagata H."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
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        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="293" mass="32518" checksum="8C714D7BF30D4DC2" modified="2011-04-05" version="1">MPVADNEVKSSWADDVEDIDGLGLPPNTEEYKNGLKIVTEYGLDDDNRKFKVVRTYKIEKRYVAKAIAQRKSWPKFGLSKEDKPGPNPATTIVSEDVAMQFITNKEDPDNKEDDPLMKLKSMQKGIVKCRICKEDHWTTQCPYKDTLLPVQEALNKAEEKKAGPPPAAAAAGGPQAKGGKEGSAYIAPALRDGGNRKGETMAMGRRTDEGCTVRVTNLSENARDSDLQELFGRIGEISRIFLSKDKNTGQSRGFAFVSYKRREDAERAIKTLNGFGYDHLILTVEWSKPSGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXB2</accession>
    <name>E9FXB2_DAPPU</name>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88052"/>
    <dbReference type="EnsemblMetazoa" id="EFX88052">
        <property type="protein sequence ID" value="EFX88052"/>
        <property type="gene ID" value="DAPPUDRAFT_230323"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88299">
        <property type="protein sequence ID" value="EFX88299"/>
        <property type="gene ID" value="DAPPUDRAFT_230321"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230321"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230323"/>
    <dbReference type="eggNOG" id="KOG3301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089738_0_0_1"/>
    <dbReference type="OMA" id="ARQFITH"/>
    <dbReference type="OrthoDB" id="1310788at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_S4/S9_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="10">
        <location>
            <begin position="9"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="109"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX88052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX88299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="194" mass="22549" checksum="E1D6ADE47890B778" modified="2011-04-05" version="1">MVNHRAPLVQRKVCVAPRRPFEKARLDQELKLIGEYGLRNKREVWRVKYTLAKIRKAARELLTLDEKDGKRLFEGNALLRRLVRIGVLEEGRMKLDYVLSLKVEDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQLVNIPSFIVRLDSQKHIDFALRSPFGGGRAGRVKRKNLKKGTDGGDAGEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXL5</accession>
    <name>E9FXL5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbonic anhydrase</fullName>
            <ecNumber evidence="4">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CAA7F</name>
        <name evidence="6" type="ORF">DAPPUDRAFT_442479</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88105">
        <property type="protein sequence ID" value="EFX88105"/>
        <property type="gene ID" value="DAPPUDRAFT_442479"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_442479"/>
    <dbReference type="eggNOG" id="KOG0382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039326_2_0_1"/>
    <dbReference type="InParanoid" id="E9FXL5"/>
    <dbReference type="OrthoDB" id="1377476at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="PTHR18952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="SSF51069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025099394" description="Carbonic anhydrase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="5">
        <location>
            <begin position="47"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX88105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="313" mass="35583" checksum="85ED9F79E35874F9" modified="2011-04-05" version="1">MKTKLISALMLVLLGFTRRLMGAGILTSVVPTLLEQNVMGNTSAVNNTWDYDETAKWPIRIAPCGGEHQSPINIEPNQAVVADYPRLSFVNYDKVFPETITNNGHTVTLQIHKHDGDDRDPPYIKDGGLSDRYIFYQLHFHWGSNNRIGSEHRIANKRYPAELHIVHYGQKYDNFTEASKHPDGLAVLAVLIEMEKRDNIAFRHIEHFDEITRPANSSSAGMNSSVTNLTNPVPLEDLLPDSPFSFYRYNGSLTTPLCNEAVIWTVFDIPIALSQRQMGEFRKLFNTEGYHLIDNFRPVQSLHGRLVTYRSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9FY19</accession>
    <name>E9FY19_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_311234</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="34"/>
            <end position="113"/>
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        <location>
            <begin position="128"/>
            <end position="199"/>
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            <begin position="266"/>
            <end position="446"/>
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            <begin position="1"/>
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            <dbReference type="PROSITE" id="PS50002"/>
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            <dbReference type="PROSITE" id="PS50106"/>
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        <source>
            <dbReference type="EMBL" id="EFX87598.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
    <sequence length="468" mass="52713" checksum="67C2E8D4D23DFF28" modified="2011-04-05" version="1">MPESAFISSHLPGHSPAHSAGGSSQHHQDRTFKVISLEKSNEPLGATVRNDGEAVVVGRIVRGGVAERSGLLHEGDEIVEVNGVEVRGKSINDVCDLVASMTGTITFLIVPVGSGSIAKSPPGVLPPNPVVHLKAHFDYDPEDDLYIPCKELGISFMKGDILHVISQEDANWWQAFREGEEDQTLAGLIPSRSFQQQREAVKQAMVIDTTENEITSRSKAGTLLCAKKQHKKKKRTSFRSNYGKEDSEEILTYEEVGLYYPRANHKRPIVLIGPPNIGRKELREMLMQDSERFAPAVPHTSRTKKDSEINGQDYHFISRTQFEADIVNRRFVEHGEYEKSYYGTTLDAIRTVVSAGKFCVLNLHPQSLKILKESNLMPFVVFVAPPSLEKLRAKKRDKGETVKDDDLKEIIEKAREMEDVYGHFFDMVIVNGEEERTYSQLVSEVNRLEREPQWVPVVWLDRNSNDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZ26</accession>
    <name>E9FZ26_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Wnt-receptor frizzled protein variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FZ2.2</name>
        <name evidence="13" type="ORF">DAPPUDRAFT_347539</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87638"/>
    <dbReference type="EnsemblMetazoa" id="EFX87638">
        <property type="protein sequence ID" value="EFX87638"/>
        <property type="gene ID" value="DAPPUDRAFT_347539"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_347539"/>
    <dbReference type="eggNOG" id="KOG3577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="InParanoid" id="E9FZ26"/>
    <dbReference type="OrthoDB" id="509772at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="PTHR11309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="SSF63501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236972" evidence="10">
        <location>
            <begin position="22"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="11">
        <location>
            <begin position="59"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F2_4" evidence="12">
        <location>
            <begin position="298"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="631"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="631"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="64"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="72"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="109"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="136"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX87638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="724" mass="79388" checksum="EFBDDEFD3F7E8A18" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZY0</accession>
    <name>E9FZY0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_236091</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87179.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Arnold G.J."/>
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                <person name="Carmel L."/>
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                <person name="Dong Q."/>
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                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
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                <person name="Manak J.R."/>
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                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
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                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
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    </evidence>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Koonin E.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="EnsemblMetazoa" id="EFX86246">
        <property type="protein sequence ID" value="EFX86246"/>
        <property type="gene ID" value="DAPPUDRAFT_313324"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_313324"/>
    <dbReference type="eggNOG" id="ENOG502QR1P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_652602_0_0_1"/>
    <dbReference type="InParanoid" id="E9G2G5"/>
    <dbReference type="OrthoDB" id="1641977at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039655">
        <property type="entry name" value="HBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15499">
        <property type="entry name" value="PTHR15499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="SSF47095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="344"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="344"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX86246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="421" mass="47103" checksum="FBB1FB62B2C9A876" modified="2011-04-05" version="1">MAAHDWKMAAQIDKGAVDGRASRCDPDETTPTVINNHCIKQTIRKIKPIPPPLDLSKRGPLDLTSSESVSDLISFSASPRSPASSNQKHLPFRKRAFSWTTFHDESGCNSLSPGPSSAIVQRSTYYGFIPTSPHISRLSVIKQESVDQSDVFGDYMSSNVGVKEDQESVAIETSSKEKPCVYSETKTMITYPAPQSPAFPTPATPSPLSPMNFPPTSTFFPPHFHPKLSSYSWSGSLLSPAPSLHSSSQEELAQCRPWKLEENEMEEESPDNIAASREESDTFHGGPLSREDYVHSEPQPGTSELCERLQRFDFVMPPAVPKNNEKRYQVTSEDTSSSLVPSPAKRPMNGFMLFAQKYRLQLIQQFPGRDNRAISVMLGDAWKRLNPAEKEVYTAEAHLRAEEYRRLFPDCWKRKRSKSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9G2I4</accession>
    <name>E9G2I4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_230516</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="GL732530">
        <property type="protein sequence ID" value="EFX86257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86257"/>
    <dbReference type="EnsemblMetazoa" id="EFX86257">
        <property type="protein sequence ID" value="EFX86257"/>
        <property type="gene ID" value="DAPPUDRAFT_230516"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230516"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049413_3_5_1"/>
    <dbReference type="InParanoid" id="E9G2I4"/>
    <dbReference type="OMA" id="LMFRTYN"/>
    <dbReference type="OrthoDB" id="1373549at2759"/>
    <dbReference type="PhylomeDB" id="E9G2I4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002084">
        <property type="term" value="P:protein depalmitoylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="3">
        <location>
            <begin position="3"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX86257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="216" mass="23213" checksum="1595F1ED3D9C1328" modified="2011-04-05" version="1">MAGKVVIEASAKHTATVIFFHGLGDTGHGWASSLAEIKPAFVKLVCPTAPTIPVTLNSGFRMPAWFDLKGLDLSAGEDTEGIQRAAVSVQSLIEEEIKGGIPSNRIVIGGFSQGGALSLYSSLVTKHTLGGVVALSCWLPLRDSFPAKIAGNTETPIMMCHGDSDPIVPLRWGEQSAALLKKFNKSVEFRTYKNLAHSSSDEEMRDLKAFIMRTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9G338</accession>
    <name>E9G338_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_44967</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732530">
        <property type="protein sequence ID" value="EFX86396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86396"/>
    <dbReference type="EnsemblMetazoa" id="EFX86396">
        <property type="protein sequence ID" value="EFX86396"/>
        <property type="gene ID" value="DAPPUDRAFT_44967"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_44967"/>
    <dbReference type="eggNOG" id="KOG0593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="E9G338"/>
    <dbReference type="OMA" id="MRFPTVA"/>
    <dbReference type="OrthoDB" id="398098at2759"/>
    <dbReference type="PhylomeDB" id="E9G338"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX86396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="329" mass="38612" checksum="7341D131BD214948" modified="2011-04-05" version="1">MERYEKICRMGEGSYGVVYKCRNRETGQIVAIKKFVESEEDPLIKKIALREIRMLKQLKHPNLVNLIEVFRRKKKLHLVFEYCDLTVLNELEKHPRGVPEVLTKRIIWQTLQAVGYCHAHNCIHRDVKPENILLTKEGVVKLCDFGFARLLNPGENYTDYVATRWYRAPELLVGDTQYGPGVDVWAIGCVFAELVRGEALWPGKSDVDQLFLIRKTLGDLIPRHMKVFKNNEFFAGLSIPEPDVRESIESKMPRDFSIDGMDFLKKCLDRDPSKRYTCDQLLRHPYFANFNFRLPESELEEYERLRRLRSRSRVSTTENRHYTSPPIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E9G367</accession>
    <name>E9G367_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DAPPUDRAFT_23503</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX86042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86042"/>
    <dbReference type="EnsemblMetazoa" id="EFX86042">
        <property type="protein sequence ID" value="EFX86042"/>
        <property type="gene ID" value="DAPPUDRAFT_23503"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_23503"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="InParanoid" id="E9G367"/>
    <dbReference type="OMA" id="KGSIFAM"/>
    <dbReference type="OrthoDB" id="1132245at2759"/>
    <dbReference type="PhylomeDB" id="E9G367"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004711">
        <property type="term" value="F:ribosomal protein S6 kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018105">
        <property type="term" value="P:peptidyl-serine phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016238">
        <property type="entry name" value="Ribosomal_S6_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000605">
        <property type="entry name" value="Ribsml_S6_kin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="29"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="291"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="35"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000605-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000605-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFX86042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="386" mass="43275" checksum="7621ACBD59136888" modified="2011-04-05" version="1" fragment="single">FNSSPDVEAVQLSETTVNPGAEKTGPQDFELRRVLGRGGYGKVFQVRKLTGKDSGHIFAMKVLKKATIVRNQKDTAHTKAERNILEAVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMHLEREGIFMEDTASFYLAEIILALEHLHCQGIIYRDLKPENILLDAHGHVKLTDFGLCKESVEDGGVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMYDMLTGAPPFTAENRKKTIEKILKGKLNLPPYLTPDARDLIRRLLKRGVVSRLGSTVADGEPVRMHPFFKTIDWNEVACRRLEPPFKPCLASADDVSQFDTRFTKQTPIDSPDDSTLSESANMVFQGFTYVAPSVLEEMHRPQVIKARSPRKGMFTQGHSMTTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G5A6</accession>
    <name>E9G5A6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_300206</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85175">
        <property type="protein sequence ID" value="EFX85175"/>
        <property type="gene ID" value="DAPPUDRAFT_300206"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300206"/>
    <dbReference type="HOGENOM" id="CLU_2429261_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX85175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="91" mass="10446" checksum="6A829CC33041390F" modified="2011-04-05" version="1">MKTQYLTVTYISWNIIFLGGISKEKYSFSLSFGKFQNYPVHFAAGTFLVVIEQKEKDKKKIVIIPISTYPFGCFIPSTPKKKSYLSKCVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9G5C4</accession>
    <name>E9G5C4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_313811</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pritham E.J."/>
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                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX84817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX84817">
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        <property type="gene ID" value="DAPPUDRAFT_7671"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_7671"/>
    <dbReference type="eggNOG" id="KOG4029">
        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX84817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="119" mass="13944" checksum="94E9810B4E13F288" modified="2011-04-05" version="1" fragment="single">RVVKRRNTANKKERRRTMSINNAFSELRDCIPNVPADTKLSKIKTLPAAQQQQQQQQLQQQHQQQHQQQQFSLNIHHKEQPKEEEPNLNGTLLCPSNGDKRSKGRTGWPHHVWALELKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9G674</accession>
    <name>E9G674_DAPPU</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DAPPUDRAFT_314450</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX84887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84887">
        <property type="protein sequence ID" value="EFX84887"/>
        <property type="gene ID" value="DAPPUDRAFT_314450"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_314450"/>
    <dbReference type="HOGENOM" id="CLU_156786_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9G674"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX84887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="102" mass="11287" checksum="6FF3AD5B2E920C52" modified="2011-04-05" version="1">MAGSTTGVPMSSWYGGYHTATPPPYYPKATYATTSYCTEVFKYYTTKAPDLNSTTYAAPSHYTDALKYYCAPSYYTTKATEDDYACCPSSEAHTPRLLHRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9G687</accession>
    <name>E9G687_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Reversed polarity homeodomain-like protein</fullName>
        </submittedName>
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    <gene>
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        <name evidence="8" type="ORF">DAPPUDRAFT_347554</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_347554"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="102"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX85034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="331" mass="36099" checksum="2CBFB4678C84B96C" modified="2011-04-05" version="1">MALNSTQVVAKAQAETRGNFHSIVMLGFQHGDLNFPHEFHHDDVHDLATTSAPPTSAGWPSCAQQTNLNATSVSSTTSGKKSENKNSKKSANDSANNSATKKKKTRTTFTPYQLEELERAFERAPYPDVFAREELALRLQLSESRVQVWFQNRRAKWRKREPPRKFQQQQQHHVHHHANNSSAATNNSVAVSATSSCSSSSSTIHHSGNGNGGFSSLLPPFASFSSYNAASHSQDWPASAATYDYCNTACSGSGNTGATSYATGYYNNNNPGSGSNFVSSYTADPFFNSSFNKGPTPTGFHEEPAPNFRDFFPPQPIKTSPTGESPDEFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6L5</accession>
    <name>E9G6L5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F3_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_46663</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX84956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX84956">
        <property type="protein sequence ID" value="EFX84956"/>
        <property type="gene ID" value="DAPPUDRAFT_46663"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG4418">
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    <dbReference type="InParanoid" id="E9G6L5"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="GPCR_3"/>
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        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
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        <property type="entry name" value="GPR158/179"/>
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    </dbReference>
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            <end position="63"/>
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        <location>
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        </location>
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            <end position="285"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="441"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="478" mass="53004" checksum="D6F308A244E315AF" modified="2011-04-05" version="1" fragment="single">GLDGVYDQEGKFECLPCPEGCDVCVDDSPCIITLNWVMRTTILILEIIVICCLPVVALFTWRYSHVKVVRAASPALLRLIILGAFFIYCTILVAYMRPNMITCSLRVWFREIGFSFAYGALMLKTWRISVIFRVRSAKAIKITDLDLIKRLGIIVSIFAVFLSIRTIVGPPHVIVAKTADDLKAYICQTDWWDHVFTAMEMVVLVWGIRLCIVVRKAPSEFNESRFISMAIYNEFLLSIFLNVSMLFLQSPANPDLMYIIMFSHAQLTTTLLLVLIFASKAYLALRGRGKDDASSTTNKPQAAKFLAKPKSANHSNVTPSGGSFRTDMIPELSSAEIRRLLCELEQLKEKTVRSGHTQFAARLAAMSQAARQVISPAAATEVIAVLDAADTAAVAAVVAGGNCLENGPSSDHSRVNKEQSDVDLRQRKTGHSVKEKIKSPKNSPDSGTFESLSSQLVSSHLIDGLIDDPTLYFWVYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9G756</accession>
    <name>E9G756_DAPPU</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX84703">
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    </dbReference>
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        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="79"/>
        </location>
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        </location>
    </feature>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="633"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX84703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="691" mass="77514" checksum="8E940041713BCDF7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8I4</accession>
    <name>E9G8I4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_239164</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Detter J.C."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Wang M."/>
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                <person name="Ye Y."/>
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                <person name="Crease T.J."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Yamagata H."/>
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                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83324"/>
    <dbReference type="EnsemblMetazoa" id="EFX83324">
        <property type="protein sequence ID" value="EFX83324"/>
        <property type="gene ID" value="DAPPUDRAFT_301936"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301936"/>
    <dbReference type="eggNOG" id="KOG0681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008246_1_0_1"/>
    <dbReference type="InParanoid" id="E9GAV4"/>
    <dbReference type="OMA" id="TNWNHQE"/>
    <dbReference type="OrthoDB" id="344271at2759"/>
    <dbReference type="PhylomeDB" id="E9GAV4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027664">
        <property type="entry name" value="Arp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="PTHR11937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937:SF16">
        <property type="entry name" value="PTHR11937:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX83324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="666" mass="75370" checksum="A2CCFD8E159D0C6F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9GCV2</accession>
    <name>E9GCV2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP reductase</fullName>
            <shortName evidence="5">GMPR</shortName>
            <ecNumber evidence="5">1.7.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Guanosine 5'-monophosphate oxidoreductase</fullName>
            <shortName evidence="5">Guanosine monophosphate reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_210496</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5 8">Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 8">
            <text>IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17185"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.7" evidence="5"/>
    <dbReference type="EMBL" id="GL732539">
        <property type="protein sequence ID" value="EFX82619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX82619"/>
    <dbReference type="EnsemblMetazoa" id="EFX82619">
        <property type="protein sequence ID" value="EFX82619"/>
        <property type="gene ID" value="DAPPUDRAFT_210496"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_210496"/>
    <dbReference type="eggNOG" id="KOG2550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_5_3_1"/>
    <dbReference type="InParanoid" id="E9GCV2"/>
    <dbReference type="OMA" id="GSHCTTR"/>
    <dbReference type="OrthoDB" id="618077at2759"/>
    <dbReference type="PhylomeDB" id="E9GCV2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902560">
        <property type="term" value="C:GMP reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00596">
        <property type="entry name" value="GMP_reduct_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005993">
        <property type="entry name" value="GMPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000235">
        <property type="entry name" value="GMP_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01305">
        <property type="entry name" value="GMP_reduct_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 7" id="KW-0630">Potassium</keyword>
    <keyword evidence="2 5" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="9">
        <location>
            <begin position="10"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="GMP binding" evidence="5">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="GMP binding" evidence="5">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="GMP binding" evidence="5">
        <location>
            <begin position="268"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="GMP binding" evidence="5">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="5 6">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="285"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="314"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX82619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="351" mass="37796" checksum="1C4314E35F73D865" modified="2011-04-05" version="1">MPRIDNDVKLDFKDVLLRPKRSTLKSRADVDLFREIKFRNSKQTIRGIPIIASNMDTVGTFEMASALAKHGLLTTIHKHYQVEEWVNFMQKNKDVAGFVAASSGSGKGDFEKLSKILNAVPEVRFVCLDVANGYSEHFVEFVRSVREAFPQHVIMAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRKKTGVGYPQISAVIECADAAHGLGGHIISDGGCTCPGDVAKAFGAGADFVMLGGMLSGHDQSGGDVIERDGKKYKLFYGMSSATAMNKHVGGVSEYRASEGKTVEVPYRGNVDATISDILGGLRSACTYTGAARLKELPKRTTFIRVTQQTNEIFSAFSSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9GF20</accession>
    <name>E9GF20_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_49696</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the bestrophin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732541">
        <property type="protein sequence ID" value="EFX81931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81931">
        <property type="protein sequence ID" value="EFX81931"/>
        <property type="gene ID" value="DAPPUDRAFT_49696"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_49696"/>
    <dbReference type="eggNOG" id="KOG3547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018069_0_1_1"/>
    <dbReference type="InParanoid" id="E9GF20"/>
    <dbReference type="OMA" id="EMYELIT"/>
    <dbReference type="OrthoDB" id="279144at2759"/>
    <dbReference type="PhylomeDB" id="E9GF20"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin/UPF0187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="PTHR10736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX81931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="330" mass="38725" checksum="062E6A383A6884F6" modified="2011-04-05" version="1">MSRSFWRNCRTCSLFDGFKSLFLLFKWRSSLYKLCYKELICLLIPYFSLTVVYRKALDEDGKRLFEQFVRYFDQYLDMISLPFILGFYVATVAARWWQQYMALPWPDRLILTIAAYVHGYDSESKKLKKTLVRHCNLMGVLLVRSLSRTNNNCKKILEEAVKLGGFMTKREKIYYESIETNVNLYWLPGLWFAQNLQAAFVQGCVKDTYAVNQIMEELLDYRGKCGTLWTYSWISIPLIYTQVVTLAVYSFFFACIMGHQRIVDPTSAENGITADLYYGFSLVLKFFFYMGLLKLAEQMICPYGDGDEHFDVDFLLNRHAQVVLLIFLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9GG88</accession>
    <name>E9GG88_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PBPe domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_102366</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732543">
        <property type="protein sequence ID" value="EFX81538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81538">
        <property type="protein sequence ID" value="EFX81538"/>
        <property type="gene ID" value="DAPPUDRAFT_102366"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_102366"/>
    <dbReference type="HOGENOM" id="CLU_635029_0_0_1"/>
    <dbReference type="InParanoid" id="E9GG88"/>
    <dbReference type="OrthoDB" id="722721at2759"/>
    <dbReference type="PhylomeDB" id="E9GG88"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="3">
        <location>
            <begin position="153"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX81538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="432" mass="48382" checksum="ECB7C788CE3565A1" modified="2011-04-05" version="1">MIAGLAGLSLILNFSIVVLFNLWIQGSHAVMDFETHLVFGKHFRIGTAEIPPYITIKHNENGTVNEVDGFVHQIVLFLAGLSISSLLATIPAFVLTMPATEIDFIATGLGVTLSRSHAIDFTFPFENEPINLLIPYPKKDSTLASILAPFEYKVWILIAVSLIVGAYMLSWSGYIKARWFTPSNQYDGIRLEMARRRGRISDNLMFLLSVLVNRKASICYRLNIILQVLFSRFNYTWSPYIAGYQVPPGFGVAFRILVAGWCLSAIVLSNSYNQSIKSFLMTPKYKSVVRSLDDLTASSEYAFVVKKYSSIWANMIEANKGPFAKIGNILRKNPENSLDTLDDITNLVINQKKVLGQKNRCSAPISTKPSSKNEKLTFDYLSGAFLLLGVGLIMSIVAFLIELFTHHYCCCRQRNNKRPLPGIEALTDEYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GGS1</accession>
    <name>E9GGS1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_317716</name>
        <name evidence="2" type="ORF">DAPPUDRAFT_327689</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732615">
        <property type="protein sequence ID" value="EFX70954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732544">
        <property type="protein sequence ID" value="EFX81072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70954">
        <property type="protein sequence ID" value="EFX70954"/>
        <property type="gene ID" value="DAPPUDRAFT_327689"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81072">
        <property type="protein sequence ID" value="EFX81072"/>
        <property type="gene ID" value="DAPPUDRAFT_317716"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_317716"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_327689"/>
    <dbReference type="HOGENOM" id="CLU_2963105_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX81072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="59" mass="6436" checksum="D20C19AD4C982CE1" modified="2011-04-05" version="1">MFDSLKETLQALNINQENTSGKEVNEGSVIEPSADMLPATDKTGSQINDILSRGIEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJA2</accession>
    <name>E9GJA2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATPase protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit c</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DAPPUDRAFT_304028</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80520"/>
    <dbReference type="EnsemblMetazoa" id="EFX80520">
        <property type="protein sequence ID" value="EFX80520"/>
        <property type="gene ID" value="DAPPUDRAFT_304028"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304028"/>
    <dbReference type="eggNOG" id="KOG3025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116822_1_0_1"/>
    <dbReference type="InParanoid" id="E9GJA2"/>
    <dbReference type="OMA" id="CSRFIAP"/>
    <dbReference type="OrthoDB" id="1564365at2759"/>
    <dbReference type="PhylomeDB" id="E9GJA2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000276">
        <property type="term" value="C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0138">CF(0)</keyword>
    <keyword evidence="8 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="16">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFX80520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="130" mass="13454" checksum="9C60F7298DC2A8B4" modified="2011-04-05" version="1">MYCARIVAPVARAALAPRSQMYLRPVSSALMAKPSEQSLVSAAPVRAIQTSAVSRDIDSAAKFIGAGAATVGVAGSGAGIGSIFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMMAFLLLFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJC2</accession>
    <name>E9GJC2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_243662</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80423">
        <property type="protein sequence ID" value="EFX80423"/>
        <property type="gene ID" value="DAPPUDRAFT_243662"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_243662"/>
    <dbReference type="HOGENOM" id="CLU_638207_0_0_1"/>
    <dbReference type="InParanoid" id="E9GJC2"/>
    <dbReference type="OrthoDB" id="1890647at2759"/>
    <dbReference type="PhylomeDB" id="E9GJC2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="421" mass="48805" checksum="40F9783AE9D6F858" modified="2011-04-05" version="1">MTIDNSRYKGDVLEIHFWLCVDRTHVWYEWCVNLPIPSNVILQKERPVLFFLLEGHGDHYLKRVMQPIPSNVNLQKERTFSFTFEGHGDHYERKGDRNQSREYLRHGNNCSALVVTNCIPHRVINSQSWVTITTTASCYSWVCIVDGVDHVCTDVSWSPAYYTTKRSNTTPKRPSTSFSAPDFTSEAPEYYTSESPEYYTSESPEYYTSESPEYYTSESPEYYTSESPEYYTSGAPEYYLTTPVKRSNTTSKCPSTSFSAPAFTTEAPEYYTTNYEVQSHYTALSYTTTAEVVNGCPLYYVGPKYFTDVLVYYTTTYATPSYYTETPKYYTDKAEYYTTTYSALVYFTEEPKFYSSPTYYETEAPVYYTTTQAPDYYTTINAAPKYNTEVPKYYTTKAPKYYLLHRSATLPQSPSSWFLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJZ1</accession>
    <name>E9GJZ1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BCL9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_304210</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732552">
        <property type="protein sequence ID" value="EFX79337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79337">
        <property type="protein sequence ID" value="EFX79337"/>
        <property type="gene ID" value="DAPPUDRAFT_319628"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_319628"/>
    <dbReference type="HOGENOM" id="CLU_086767_0_0_1"/>
    <dbReference type="OrthoDB" id="1793754at2759"/>
    <dbReference type="PhylomeDB" id="E9GMB6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX79337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="243" mass="27580" checksum="1AA9D36B13404926" modified="2011-04-05" version="1">MWYLNKNSIPTLFLGQTVDLKKSGKLQSDVECQLKQYEYAVSEFQTSKTSLSVVEIEATRLILTKDECGIPQNLTSRKRELQFNGNTQSWSYECVRLPENELLNSSPSSLIPFIEGDEEGSTPCVSLECTTAPSSDSIVAPFVSRCSSMTEIPLRKSTRQKTRPQRYRGTDNDLNMRYARMMKTRSRSTKLRKPLINAVRSVNVEPVVECESLESYHVDDVDGFLIFSFVTSEDLVKFCADQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9GMT4</accession>
    <name>E9GMT4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SURF6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_304910</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SURF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732553">
        <property type="protein sequence ID" value="EFX79234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79234"/>
    <dbReference type="EnsemblMetazoa" id="EFX79234">
        <property type="protein sequence ID" value="EFX79234"/>
        <property type="gene ID" value="DAPPUDRAFT_304910"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304910"/>
    <dbReference type="eggNOG" id="KOG2885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047883_1_0_1"/>
    <dbReference type="InParanoid" id="E9GMT4"/>
    <dbReference type="OrthoDB" id="1249614at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="PTHR14369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURF6" evidence="4">
        <location>
            <begin position="150"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX79234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="364" mass="40880" checksum="B09C95AA12DC592F" modified="2011-04-05" version="1">MSKSFESGKIDKRKSKSGKNSSGPVMAPAILVNGKTENKNSKLSTKQNMKKMDPKSPEPEEKRGPIDIAALKLQLSSEDLFISSLLTNIPTQGVSTVQDVEGDEMSVDNSSTKQIDVGNRACNPEELKERLAAKLSQFTGKKMDFSDKKMKTKLKRKLDKIEKKKLKRKNNKMRSKIAKLAQATKAATASSNFPSTETVKTEVPEPTVTSRPPKPIFNSEGRMVFSKFDFGELTTPSPILKKTTLDPKAAMIKIKKTKEKVKFLEAKGDIEKARSIEEQQAWEGALLRAEGVKVKDNVELLAKSIKKKDKIKLQSKKKWGERVEAQEKKKEDVQKKRNANIKKKKNEKKEHKLNKLAKKGKFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9GN86</accession>
    <name>E9GN86_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_104756</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732554">
        <property type="protein sequence ID" value="EFX78990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78990"/>
    <dbReference type="EnsemblMetazoa" id="EFX78990">
        <property type="protein sequence ID" value="EFX78990"/>
        <property type="gene ID" value="DAPPUDRAFT_104756"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_104756"/>
    <dbReference type="eggNOG" id="ENOG502S31R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138031_2_0_1"/>
    <dbReference type="InParanoid" id="E9GN86"/>
    <dbReference type="OMA" id="CSPRDSI"/>
    <dbReference type="OrthoDB" id="1468993at2759"/>
    <dbReference type="PhylomeDB" id="E9GN86"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33559">
        <property type="entry name" value="PTHR33559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX78990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="117" mass="13165" checksum="64AACA526279B539" modified="2011-04-05" version="1">MSPIGIHQFSGKVLDKNVCFQALKLTDQLLLWIGMESDPSFKDFAVAMSTPYEKSPTTVKMLGDPSSLTSSTLASRLSKRCKKPVFVSFNISETNQELFTKIEERLLEEIMISPELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9GNB2</accession>
    <name>E9GNB2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_319936</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX79001">
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        <property type="gene ID" value="DAPPUDRAFT_319936"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
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        <location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
    <sequence length="547" mass="62447" checksum="4046886426772130" modified="2011-04-05" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX77565">
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        <property type="gene ID" value="DAPPUDRAFT_213399"/>
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    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_213399"/>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Wang M."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732562">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305794"/>
    <dbReference type="HOGENOM" id="CLU_809547_0_0_1"/>
    <dbReference type="InParanoid" id="E9GSK4"/>
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    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237400" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX77444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="343" mass="39161" checksum="EC910DF72CD820FE" modified="2011-04-05" version="1">MQFWQCPLLLMVSLIAAINTQQTPSQRLEPNQVAGLVELHQQLEQPREHQQQQQHHQQQPEQPAQADNKDYAPSPAVLLQLTPSDWKNTQDKRNNWNRMQGMWGKRSQQQSDESALSEMTPPRMVKRAWSDLSQQGWGKRSWTQLHGVWGKRRWDQLHGAWGKRTPDQLEDDSKAEQPENSQEDEDQQSSSEVEREEANDSDDTVENSKRSGWNKMQGVWGKRSSSSSKTNSGPAIEGMGNNDLLLLISGTGDQLYQQREDDQAKANVEDAGNEESVDKRGWNQLQGVWGKRALSAMAAGYKRNWNNLRGAWGKREIPAAIAKGMEWSRKRESGWNNLKGLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9GSX2</accession>
    <name>E9GSX2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_106153</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732562">
        <property type="protein sequence ID" value="EFX77507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77507">
        <property type="protein sequence ID" value="EFX77507"/>
        <property type="gene ID" value="DAPPUDRAFT_106153"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_106153"/>
    <dbReference type="HOGENOM" id="CLU_582990_0_0_1"/>
    <dbReference type="OrthoDB" id="668449at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="357"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="469" mass="53474" checksum="F987B8600D9707C2" modified="2011-04-05" version="1">MASSHLHPDENSSDKFRLAESIYLPAQLLTGLCHCNEHGESPLMIAHTVEHSDFKWDVLSFLSLHGSSVYKELPKLYEIAFYEISQEFPADIFVDTFVEFVEDTDWMEIVVSMRSKSTSFDREEKIEALEFVGATLIIESFGFQLSAYDHHIQTSSLGLQCWKEAMDLRFTGKLLFVLCVYVNLCCQTPHVYVTSSASDKVFGSMQEPTSVAELTAFFEDYQRHCVGGEIDDSRLRFENTLKIQALLVTRRICSAANIFKQSFYRERLINRVAYSSEITNLGELLYHLYYVLTYSTEELTKLEWQHLVKNILYYSRSLFAERTDTVLHVAVRQLLVITGELRKIIKLGADSNAIDQNGRTPLHLLAARCNGHPEYFAYVIETMVDAGTHLDIAADDGKTVVRILGDIVEEWKAAQISVVPYYESLTNTVFPLSCYCARVIGQQGIRYDEDRLPLHLQEFVSRHSAAQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9GT44</accession>
    <name>E9GT44_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_247913</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732563">
        <property type="protein sequence ID" value="EFX77336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77336"/>
    <dbReference type="EnsemblMetazoa" id="EFX77336">
        <property type="protein sequence ID" value="EFX77336"/>
        <property type="gene ID" value="DAPPUDRAFT_247913"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_247913"/>
    <dbReference type="eggNOG" id="KOG0077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1012875_0_0_1"/>
    <dbReference type="OrthoDB" id="1168548at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="PTHR45684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX77336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="275" mass="31135" checksum="0A3387C80C38D872" modified="2011-04-05" version="1">MAAIRYRRVTAELVAAAAAASNLATSHEAEATYIEEHLPSPTLDPYSPQTDGCGWGREGQLHLVLWQQLPQNKTEFENWLNSQESSSQFLITWELELKAQLEEFKIHHIENNTPSIPEVYHDITASNVVDYPLPLEAPERGERTLLFLCGRKSRLVVRIICFHIHNVCLGLVCWSPWDVRINLVDAFDAQCFAESKNELFSLLADEQLGHCPILVLGNKIDRPGAASEEKLRVYFELHNTTGKGKTPRSQLSSRPLELFVCSVLKRQGYGEVFCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTM8</accession>
    <name>E9GTM8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_248090</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Thomas W.K."/>
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        </source>
    </evidence>
    <sequence length="453" mass="50967" checksum="08DFC16408EE430B" modified="2011-04-05" version="1">MSEPNSDSAPGNGKQQTPDKRKLTPMKDSSPSTSLYSENVSPAVNRKFTPTISQNCIRGTTVQPDSVVPQWQNCRSTRTGFMTHAIVRNGQQQDKRKNTPMKDSKPSTSSSEILSPVAKRKFKPTIPPDVRVRGTVQPGREVPRFAVPQWPNRGRSSPQSERRLGAQQAFQPRPKLIQFSQPPSSAPANNLVMLKNFSVKMEGSLYPRGLADIGKKKRASTSKSEIQESSEFDPFIVHWMQLIRQANRKFKPTIPPDMRFSPPPNSAPANNLVMLKNFSVESVNILTPNIPPRRVKTAEKSPRLEVQPDRGVPQRPNHGRGQSERRLGAKEMKGSLYGQGLADSGKKRRASTSKPEIQESSDPFKPALDAVDQYEHVDRLVLKRVSPIKNEDEVFVEQNMSQKLKFHQKEGVKFIYCFLQPRSLLGWKKEMQLSQTVEFLKGETVARVTPEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0P9</accession>
    <name>E9H0P9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_307005</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732581">
        <property type="protein sequence ID" value="EFX74712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74712">
        <property type="protein sequence ID" value="EFX74712"/>
        <property type="gene ID" value="DAPPUDRAFT_307005"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307005"/>
    <dbReference type="HOGENOM" id="CLU_673125_0_0_1"/>
    <dbReference type="InParanoid" id="E9H0P9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX74712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="262" mass="27813" checksum="9D65745120957052" modified="2011-04-05" version="1">MTTTIAPMVYTSSIAPPVAYGVTQAPYAAPAGPVYPSAPESVRLTPMMVMPDSLLVEEDIGESGLTKLLKKAMIALPLAIVLPIAIPLIFVIKYLISGGAYAGNIPFFGAATETPILQQTTPFFTTGMPTTTVPPYNGPQGFYTGPGSGGYGGGPQIPQNDQNWSQRKRREADASSSGLPSMSLAQVERLTKVVFAAMRSQECIQRLLCEVGSMSKSFSDTAHSVAVAVESFVPESIKASYDVFAKAENCEQYVCGSLKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9H1B7</accession>
    <name>E9H1B7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_251957</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732583">
        <property type="protein sequence ID" value="EFX74448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74448">
        <property type="protein sequence ID" value="EFX74448"/>
        <property type="gene ID" value="DAPPUDRAFT_251957"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_251957"/>
    <dbReference type="HOGENOM" id="CLU_2833778_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="66" mass="7394" checksum="E539860D2B070C97" modified="2011-04-05" version="1">MTCRPFVAPIEPAPWDEPDPTTRPASFDYPTDCRWVNASNKATSDDSNLAMNGREPLVQDHNSVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9H220</accession>
    <name>E9H220_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_307414</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDV3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732585">
        <property type="protein sequence ID" value="EFX74211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74211"/>
    <dbReference type="EnsemblMetazoa" id="EFX74211">
        <property type="protein sequence ID" value="EFX74211"/>
        <property type="gene ID" value="DAPPUDRAFT_307414"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307414"/>
    <dbReference type="eggNOG" id="ENOG502S35X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089760_0_0_1"/>
    <dbReference type="InParanoid" id="E9H220"/>
    <dbReference type="OMA" id="SSKMYIS"/>
    <dbReference type="OrthoDB" id="1568537at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026806">
        <property type="entry name" value="CDV3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16284">
        <property type="entry name" value="PTHR16284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15359">
        <property type="entry name" value="CDV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX74211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="271" mass="29653" checksum="AD492EDD12F06524" modified="2011-04-05" version="1">MADLDDFFAKKDKKKSKVKKFTASDLMTSSKFGEDVAAPPTGVPKKQPAAERPKKEEVTVQETVDSEGVSVKSKPTVEVEEEEWGEFEQEKERDYSGLKIQKLQIQDSEDDYGDESGETELNEEGEIIKKEPAGPWNKINAQPTPTAVKVKEAAVEIPTPNTSGGVYIPPTRRLQSAGGSSSSSSAASKSRTGKKEKGAPDLSNQDYFPTLSAAVAIEQNNYKLKKFEQTERGFTEAKPSRSHSNRNAVVPGHEGPHLHLGNKFNALSNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2H2</accession>
    <name>E9H2H2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_324698</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
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                <person name="Gilbert D."/>
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                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Pritham E.J."/>
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                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732594">
        <property type="protein sequence ID" value="EFX72921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72921">
        <property type="protein sequence ID" value="EFX72921"/>
        <property type="gene ID" value="DAPPUDRAFT_253739"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_253739"/>
    <dbReference type="HOGENOM" id="CLU_678372_0_0_1"/>
    <dbReference type="InParanoid" id="E9H5S7"/>
    <dbReference type="OrthoDB" id="1716958at2759"/>
    <dbReference type="PhylomeDB" id="E9H5S7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX72921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="406" mass="47432" checksum="7E564866B0531AE2" modified="2011-04-05" version="1">MIIGKYSRLSFRILVPFMPCTSHRVPHYDIFECQEETCWVVTLLVPPEGTHLRTMSTTRQSVRLGFTLLVITTLLLLLGTIMDEPILESQTFGNPSIDPADDGYRNDEDEYLNRRYFRLRTDVVSYDTRETDSEEQTASGSGSGGVRTPSHIREFRKADAVRCLDALSVKRNRRPMHIAFIGDSTVRQHFVSFIRWIPDYDRKISRNSTMYAEYYFHEDRNISSPLMDNLLVSFYWRRLIQEDLIADFKRWASTDDDNQVPDFILLGVTAHHIAENRNLTIEMYENLLENELMPLINKSLNAHPRQEIIWLQQSPTIQTFQSGSVYPELIAKYNKEIRRIFKNTRVVMWDAINVVVEEYVRSCALAKLERRDKEWYSKCNDFIHPGFRALSIGTQLIINHLCEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6G3</accession>
    <name>E9H6G3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FR47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_110500</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732597">
        <property type="protein sequence ID" value="EFX72651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72651">
        <property type="protein sequence ID" value="EFX72651"/>
        <property type="gene ID" value="DAPPUDRAFT_110500"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_110500"/>
    <dbReference type="eggNOG" id="ENOG502QVR1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080250_0_0_1"/>
    <dbReference type="InParanoid" id="E9H6G3"/>
    <dbReference type="OMA" id="AYEAINI"/>
    <dbReference type="OrthoDB" id="1221333at2759"/>
    <dbReference type="PhylomeDB" id="E9H6G3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FR47" evidence="1">
        <location>
            <begin position="215"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX72651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="302" mass="34670" checksum="F5CDD9A647A9BCBC" modified="2011-04-05" version="1">MEQQSQAKNDDGFLTLATRKCLFRLLSFLDSRLPEYSAIHSFVCAALLTANPSYHVYFRRASSASGDEENYSLIIGLGVECFVQPNQQTKKCWTVTAWTDDDEKLASAYEAINIIDWNTDAVIMHYKFHAPHPAIDNLVKNKHGEGKDNKICYPSDQYFMPVKDALNLQISEIDGVYVKSLERCHAQIVYDYWPYRESTTVENITKEIELLPSAGVFLKGNDQLVSWMMCHLPNGMSRLHTLEEHRRRGYAALVTQYLSKRVAQCGFVPFANIVIENTASYKFFESMKFKHLRPIHVQYSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9H5</accession>
    <name>E9H9H5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VLIG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_327021</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732608">
        <property type="protein sequence ID" value="EFX71618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71618">
        <property type="protein sequence ID" value="EFX71618"/>
        <property type="gene ID" value="DAPPUDRAFT_327021"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_327021"/>
    <dbReference type="eggNOG" id="ENOG502QVVR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004407_0_0_1"/>
    <dbReference type="InParanoid" id="E9H9H5"/>
    <dbReference type="OMA" id="DCENEEN"/>
    <dbReference type="OrthoDB" id="31942at2759"/>
    <dbReference type="PhylomeDB" id="E9H9H5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030383">
        <property type="entry name" value="G_VLIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51717">
        <property type="entry name" value="G_VLIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VLIG-type G" evidence="5">
        <location>
            <begin position="671"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX71618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1639" mass="186871" checksum="87318758108F5383" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9HBT2</accession>
    <name>E9HBT2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="6">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_60895</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="GL732617">
        <property type="protein sequence ID" value="EFX70816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70816"/>
    <dbReference type="EnsemblMetazoa" id="EFX70816">
        <property type="protein sequence ID" value="EFX70816"/>
        <property type="gene ID" value="DAPPUDRAFT_60895"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_60895"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_3_0_1"/>
    <dbReference type="InParanoid" id="E9HBT2"/>
    <dbReference type="OMA" id="RTCHFKD"/>
    <dbReference type="OrthoDB" id="405736at2759"/>
    <dbReference type="PhylomeDB" id="E9HBT2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX70816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="450" mass="52001" checksum="F0FAA62EA9376AF2" modified="2011-04-05" version="1">MDHRATARIAIIGAGPSGLSQMRAFALLESSGQKIPEIVCFEKQNDWGGMWNYTWRTGFDEYGEPVHGSMYRHLWSNAPKECHEFADYSFDHHFSKSIPSFIPREAFRDYILGRAEESNMRRCIQFNTVVSYVEFDREKEIFHVRKKNLTTGKSSIEDFDYVIVAVGHFSMPNVPYVEGIETFPSQVIHSHDFRDARQFAEQSILVIGGSLSAEDIALQTFKFGAKSITISYRTKPIGCKWPSKIEEKPLLTRMEGRSAHFPDGSERNFDSIILCTGYKHHFPFLNDDLRLVTTNCFYPSQLYKGIFFQEQPRLIYLGMQNLYFSLSLFDAQTWYVRDVILGRIPFPNKLQRAEDMLAWKTREEKIEDKLDALDFQTAYLKELTSATDYPLDDLRLSGTAATFKNFLDDKESNIINYRDKQYASSITGTKAVMHPTPWMEVNNYSSVDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HD13</accession>
    <name>E9HD13_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_328135</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732622">
        <property type="protein sequence ID" value="EFX70374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70374">
        <property type="protein sequence ID" value="EFX70374"/>
        <property type="gene ID" value="DAPPUDRAFT_328135"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_328135"/>
    <dbReference type="HOGENOM" id="CLU_3016267_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="56" mass="6195" checksum="3B57AE981787284C" modified="2011-04-05" version="1">MTRSNPTSSCFCAPDSRQRCAVKEIGREYPAAEEAVQRSITWHPVTEDVIIKANGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDE8</accession>
    <name>E9HDE8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_129909</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732623">
        <property type="protein sequence ID" value="EFX70260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70260"/>
    <dbReference type="EnsemblMetazoa" id="EFX70260">
        <property type="protein sequence ID" value="EFX70260"/>
        <property type="gene ID" value="DAPPUDRAFT_129909"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_129909"/>
    <dbReference type="eggNOG" id="KOG2740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026996_6_2_1"/>
    <dbReference type="InParanoid" id="E9HDE8"/>
    <dbReference type="OMA" id="WDIGRID"/>
    <dbReference type="OrthoDB" id="928391at2759"/>
    <dbReference type="PhylomeDB" id="E9HDE8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="SSF49447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SSF64356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="180"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX70260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="425" mass="48206" checksum="FE7044923DCE958E" modified="2011-04-05" version="1">MIHSLFVINHSGDVFMEKHWRSIIPRTVMDYFFEAQRQVVKDNKGHEDVPCVIATPHHYLISIYRNGLYFVAVCMSEVPPLFVIEFLHTVVDILEKYFTECNESNIKEHYVVVYELLDEVLDNGYPLATEPNILQELIKPPNIIGNLINTVTGKSNVSSVLPSGQLSNVPWRRADVKYTNNEAYFDIIEEVDAIIDKTGSTVFAEIAGKIECCVRLSGTPDLTLSFINPRLMDDVSFHPCVRLKRWENERILSFVPPDGSFCLMTYHVGCQSAVAIPIYIRHNFFLPKENSQSQTGKIEITVGPRQTMGRVVENLQLSIPMPKFILNCTVTLNQGRATFDPVTKILLWEVGKIDPTKLPNMRGQIHIQSGAVILQSTPSVNVQFTLTQIAISGLKVHRLDMFGENYKPFKGVKYLTKAGNFQIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9HEZ1</accession>
    <name>E9HEZ1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AlaDh_PNT_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_328858</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732632">
        <property type="protein sequence ID" value="EFX69700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69700">
        <property type="protein sequence ID" value="EFX69700"/>
        <property type="gene ID" value="DAPPUDRAFT_328858"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_328858"/>
    <dbReference type="HOGENOM" id="CLU_003376_2_3_1"/>
    <dbReference type="InParanoid" id="E9HEZ1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008746">
        <property type="term" value="F:NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX69700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="118" mass="12616" checksum="67C9C4D5DCD58228" modified="2011-04-05" version="1">MVSTLGFRPAVREQVESLDAESMIVEAQQSHEDKGRFLQPFSTIDVVMRTALIPGKHALQSLSAKHTYLLKSGSVVIDLAAHAGGNCALSRLAETIVTPQGVTIVEEGNAPRHLPGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HH16</accession>
    <name>E9HH16_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_301222</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732644">
        <property type="protein sequence ID" value="EFX68981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68981">
        <property type="protein sequence ID" value="EFX68981"/>
        <property type="gene ID" value="DAPPUDRAFT_301222"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301222"/>
    <dbReference type="HOGENOM" id="CLU_3070771_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="53" mass="5944" checksum="A7ADB07130F88E57" modified="2011-04-05" version="1">MLGCSVGLVLAHSFWLAGCHILSGYCFFFFHCSYVFVFARLMLEKSRASHVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9HH74</accession>
    <name>E9HH74_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_62821</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732646">
        <property type="protein sequence ID" value="EFX68891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68891"/>
    <dbReference type="EnsemblMetazoa" id="EFX68891">
        <property type="protein sequence ID" value="EFX68891"/>
        <property type="gene ID" value="DAPPUDRAFT_62821"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_62821"/>
    <dbReference type="eggNOG" id="KOG3628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1044146_0_0_1"/>
    <dbReference type="InParanoid" id="E9HH74"/>
    <dbReference type="OMA" id="ERISCYI"/>
    <dbReference type="OrthoDB" id="1500698at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="267" mass="29107" checksum="11F34C4D6CDE27F0" modified="2011-04-05" version="1" fragment="single">SWKVSAKIQQAPQHAEAAQASPLLEFYEDDGIEQEVAANPKDPNAPQPEGGHITPAIGDQLRSLEAAIQRYGSSSYKAAAATVLDPNGKMFTTLTYGTFSHFFIFLFPGKLQSRYYKIAYALLNKLSKHGGVGVVRSGTDELMGSSSVKPGDRVALVYTNSDAIAFICAFYCCLHAGVVPVPIEVPLTRRNTGSQQLGFLLVSCGVQEALTSDICLKGLPKTASSGEIIAFKRCLKLHWCVTDNLINPPKDWQPRPKLRTIRQPTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HHA0</accession>
    <name>E9HHA0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_329660</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732647">
        <property type="protein sequence ID" value="EFX68826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68826">
        <property type="protein sequence ID" value="EFX68826"/>
        <property type="gene ID" value="DAPPUDRAFT_329660"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_329660"/>
    <dbReference type="HOGENOM" id="CLU_1157427_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX68826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="240" mass="26468" checksum="3E3D7334608C59CA" modified="2011-04-05" version="1">MFQTEEADSAKLSNLCSEKVSIEQEMKDTCLQLEKLQNTFEEALLQIIQIKSQISKLQEHHHHFDKPLMAHDKILVESEVASWLGDNVLRPLASVASQNLPLPKYDHDKLIEETSHFNDGALDSGPFNSQHRGFSDSSNEDSFMDQNCIKMAAQKITPVDLSSVKRPFTSAFSANVEESFKGRTGRVGNPIPALPPVKSKQPRPVSSKAVTATKVRKHQALPTGSTISPAPLTFANASYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9HHA9</accession>
    <name>E9HHA9_DAPPU</name>
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        <recommendedName>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX68880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68880"/>
    <dbReference type="EnsemblMetazoa" id="EFX68880">
        <property type="protein sequence ID" value="EFX68880"/>
        <property type="gene ID" value="DAPPUDRAFT_259486"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_259486"/>
    <dbReference type="eggNOG" id="KOG4430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1679720_0_0_1"/>
    <dbReference type="InParanoid" id="E9HHA9"/>
    <dbReference type="OrthoDB" id="1527304at2759"/>
    <dbReference type="PhylomeDB" id="E9HHA9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX68880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="162" mass="18626" checksum="01E936B1FFBB09AA" modified="2011-04-05" version="1">MANNKEFRSPCQNYDDGTCAICLSSHINKSTPNCGHVFCFRCLIDWCQIKFECPTCKQPFQNFRHTIQIRPTGDQIYTPDPPAAPVENPRVTDLNFTVINEGHRDLQSWVIRSANRMIVIPMPTSSHDRLNDPGFRLRFFAFLNRQFDINVIDMVSVATDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9HHW1</accession>
    <name>E9HHW1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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    <organism evidence="2">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68618"/>
    <dbReference type="EnsemblMetazoa" id="EFX68618">
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        <property type="gene ID" value="DAPPUDRAFT_114337"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_114337"/>
    <dbReference type="eggNOG" id="KOG1366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX68618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="304" mass="34391" checksum="D5248B431DF48C31" modified="2011-04-05" version="1">MQQVHQHQFGVEHYYIPFFVVVPSAPAYVLDSDETYTVEVTSSVHTQFVANGNLTVHVYAASTPGQSTNHEFTYDVNLGDVKSAIRSRSLDGWLRYFMGEARDGFIETRVIHAQLKFKFSGAKTAVFKPGMPFEGHVYVMYDDDQALTSDKLAGANTITLRPVVTSTNGQMKTLSEIKVPAKGEYLNHHQQEDGNKYSKEYDNWMEHQIEDVKFNQFRATGVYNFRFSVPKDAKSMRISATYKDGDGDKATAELQAVPFYSAKEMYAHVETSTEYGQLGENVVIHLRSNFEFQVYSYVVSSSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9HIU3</accession>
    <name>E9HIU3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_114642</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732657">
        <property type="protein sequence ID" value="EFX68351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68351">
        <property type="protein sequence ID" value="EFX68351"/>
        <property type="gene ID" value="DAPPUDRAFT_114642"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_114642"/>
    <dbReference type="HOGENOM" id="CLU_714263_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HIU3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033052">
        <property type="entry name" value="Cmr1/WDR76"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="PTHR14773:SF0"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="387" mass="44536" checksum="7301BF762298FF8B" modified="2011-04-05" version="1">MEIFVEFRDDEDGENFLAELKKRPTDKFEASRYDHLIKPLPQIRDECVQVHPDSRPIQTVETLLNHQSRTHPLEGFICILKLLCLGHGRGNSSVVDECLRDEEEPRRIQFSGNMEDFIDVKAGDHIEEKNMPLGSPEQNNRRVIVTRSKTNNLAASKQLPCFSYELNSSKRSGKPRRNAAVAKKRSHAEVDDEEVLKSPPAKKKNRGISEYELEVQKNIEERKKMFEMLKFGDAKQGFLDVLPNQRKRKVDEVKEDIDEYYNKLNLNLDSSLICVYVINRNDVPVKRGRPKSGESRPKRAKVEKSNESLLEMCNQPCKMKLRSRRNRDKVIPVTESSTKDDLKSDEMFNNEFDSNATGATMTLKNTYADQSSVDESSLMNLQILSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJ50</accession>
    <name>E9HJ50_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Actin-related protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_301521</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the chromatin remodeling Ino80 complex. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the actin family. ARP8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732660">
        <property type="protein sequence ID" value="EFX68180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68180"/>
    <dbReference type="EnsemblMetazoa" id="EFX68180">
        <property type="protein sequence ID" value="EFX68180"/>
        <property type="gene ID" value="DAPPUDRAFT_301521"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301521"/>
    <dbReference type="eggNOG" id="KOG0797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006974_1_0_1"/>
    <dbReference type="InParanoid" id="E9HJ50"/>
    <dbReference type="OMA" id="CFIQESL"/>
    <dbReference type="OrthoDB" id="1258783at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027668">
        <property type="entry name" value="Arp8/plant_Arp9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="PTHR11937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937:SF13">
        <property type="entry name" value="PTHR11937:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX68180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="559" mass="61894" checksum="F0E19734F3A5873D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJC0</accession>
    <name>E9HJC0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_260508</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732661">
        <property type="protein sequence ID" value="EFX68144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68144">
        <property type="protein sequence ID" value="EFX68144"/>
        <property type="gene ID" value="DAPPUDRAFT_260508"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_260508"/>
    <dbReference type="HOGENOM" id="CLU_2087208_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="117" mass="12487" checksum="5EFE8665B1A227EB" modified="2011-04-05" version="1">MSEFEPIPEEIPRQSRSAQKDGGSSDRKSKSSDKHAVKEKKSRSSKNKEGRSSSKGDSPPSGQGGHGHGRLGSNGSSKSGSKHKSEPLISLTATAEMDMGLPETSNNSHDVVQHQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLG3</accession>
    <name>E9HLG3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_261687</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732678">
        <property type="protein sequence ID" value="EFX67436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67436">
        <property type="protein sequence ID" value="EFX67436"/>
        <property type="gene ID" value="DAPPUDRAFT_261687"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_261687"/>
    <dbReference type="HOGENOM" id="CLU_1961788_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="128" mass="14699" checksum="AF16D82BE4033040" modified="2011-04-05" version="1">MSVTKQNQGKVKFLKKLTLTEQYRLNNPDFVAATGEEDYGEKKLEKGRNDKLNSSQMLSHPDDKSQETNVKDFENKHVFAFRCHGHLLEVFGPHLQGQVCVDADQTCQAKPFFILIECFGSKDELEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9HM76</accession>
    <name>E9HM76_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetyl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetyl-CoA deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_331345</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="3"/>
    <dbReference type="EMBL" id="GL732685">
        <property type="protein sequence ID" value="EFX67096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67096"/>
    <dbReference type="EnsemblMetazoa" id="EFX67096">
        <property type="protein sequence ID" value="EFX67096"/>
        <property type="gene ID" value="DAPPUDRAFT_331345"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_331345"/>
    <dbReference type="eggNOG" id="KOG2828">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030703_1_0_1"/>
    <dbReference type="InParanoid" id="E9HM76"/>
    <dbReference type="OMA" id="EKMGIWR"/>
    <dbReference type="OrthoDB" id="1016647at2759"/>
    <dbReference type="PhylomeDB" id="E9HM76"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="6">
        <location>
            <begin position="299"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX67096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="429" mass="46512" checksum="7922CD0FFC275832" modified="2011-04-05" version="1">MYFSGLFKKFNRGIIRHYYSYAAEPFHPLPRTPVTLSAEEAIKVVKSGDTVFVHSAAATPTKLLAALANHGKESRLEKVTVCHIHIEGPMEYLKPEYSGIFRDNSFFIGSNAREAVNSGRADFVPIFLSEIPLLFHRKIIQLDVALINVSPPDQHGFCSFGPSVDVTRSAVKNAKYIIGQVNPKIPRTFGDGTIHVSHLDCIVNVDEELPMRYPAKSSPIEIAIGRLIADNLVENGATLQMGIGNIPDAVLSSLKSHTDLGIHSEMFSDGVVDLVEAGCITNSQKKILPGKIVGSFCLGSRRLYDFLDNNPFIVMGDVQWVNSSSLIAQNPKVTAINSCIEIDLTGQVVSDSIGTRMYSGVGGQVDFLRGAGLCPDGGKPILALPSSTKKGESAEIDASDQVDGCSEVPYLKGPAITHYKCHDPNLKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNG0</accession>
    <name>E9HNG0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_331794</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732695">
        <property type="protein sequence ID" value="EFX66749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66749"/>
    <dbReference type="EnsemblMetazoa" id="EFX66749">
        <property type="protein sequence ID" value="EFX66749"/>
        <property type="gene ID" value="DAPPUDRAFT_331794"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_331794"/>
    <dbReference type="eggNOG" id="KOG1033">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2374880_0_0_1"/>
    <dbReference type="InParanoid" id="E9HNG0"/>
    <dbReference type="OrthoDB" id="64059at2759"/>
    <dbReference type="PhylomeDB" id="E9HNG0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX66749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="95" mass="10909" checksum="F5624E59B356FC30" modified="2011-04-05" version="1">MSTIDETDEPSLTFSELNQQDDDSLFYESRFLEDFQPVSLLGRGAFGRVFEARKLIDQKHYAVKRIKLPSNKEARAKVMREVTVRGEIGNVVDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNL6</accession>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732696">
        <property type="protein sequence ID" value="EFX66690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66690">
        <property type="protein sequence ID" value="EFX66690"/>
        <property type="gene ID" value="DAPPUDRAFT_331842"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_331842"/>
    <dbReference type="HOGENOM" id="CLU_1344478_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX66690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="204" mass="23749" checksum="20739486410576F0" modified="2011-04-05" version="1">MPFGSYSQSFVTFIEKTGNRILKPFTNEDDSFSRWLAYVEQYFSALSETVTTWMGEQWKWPTAGSSKVLAEISTVFRKIAEEYDFRQKLSEELLVGLMPEIGVPLRTLLKNSWNDVYQVIRSLVLRGFVTVEAAAWNVMNEVLDYFYKHREAIFGSTYFQKLSLLLDDLKQFYLDMQSTDWPSRVRNYVIRAGQFLQTKIPGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNS8</accession>
    <name>E9HNS8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_262845</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX66606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_262845"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_262845"/>
    <dbReference type="HOGENOM" id="CLU_2075491_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
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    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54928"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX66606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="118" mass="12930" checksum="5E12E9D7B5A85D8F" modified="2011-04-05" version="1">MAAPLTSTCVTNLTTLSTSMESELTQQNRNVSNTLTENSVVQFYSVSSDVTDAHLADFFSQCGPVNHIERLTSKEGKKTVFVELAADMVAYKASKKSVVKGIWMTSMSQDTVEKKITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HQI5</accession>
    <name>E9HQI5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732720">
        <property type="protein sequence ID" value="EFX66004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66004">
        <property type="protein sequence ID" value="EFX66004"/>
        <property type="gene ID" value="DAPPUDRAFT_116789"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_116789"/>
    <dbReference type="HOGENOM" id="CLU_1490492_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX66004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="181" mass="20364" checksum="E53580694D8A2D02" modified="2011-04-05" version="1">MGNPRYDPFRRHYKKDTRFLLDLYTLTYDSGESLCTVDCRVGGSHGPNSKSQAFVSKNFKVFQKSAIRKSTLSGSECIEKSGDFCAHVERVNKELLYVRLGNHFLFLFHALVSINTLDQVDGTRAYISTLLARAGCLSGFLPSRMAQVEGEEVNEAHFNENIDIYDDPSFTHQGVVLLLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9HRP0</accession>
    <name>E9HRP0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_333044</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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        </lineage>
    </organism>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_333121"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EFX65522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="56" mass="6633" checksum="7E7F83DBF4C3EED0" modified="2011-04-05" version="1">MEQKKFRIPEDMFPTSMVSQFEKAELFLESAFNKTKLAEECRGIISKDEMENDEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HS28</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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            <authorList>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX65460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65460">
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        <property type="gene ID" value="DAPPUDRAFT_117261"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_117261"/>
    <dbReference type="HOGENOM" id="CLU_1760626_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="EFX65460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="148" mass="16653" checksum="DD66C79A6ABA8DC5" modified="2011-04-05" version="1">MAAKVAKMAHRHIVAKGSNVEAHTPNQPMWEMSLERNNQDVTINDLFLCSLKDVLEMPNSTENKRLKAVGWAISTMSASLSLHPALTCAQYLRGLDLVKSKRTMSVQIGTGDLQQTGNQRLFHFIRSRNSENVREAHSSGNYWRESSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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    <organism evidence="3">
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732778">
        <property type="protein sequence ID" value="EFX64918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64918">
        <property type="protein sequence ID" value="EFX64918"/>
        <property type="gene ID" value="DAPPUDRAFT_117724"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_117724"/>
    <dbReference type="eggNOG" id="ENOG502T8YR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060623_2_0_1"/>
    <dbReference type="OrthoDB" id="279711at2759"/>
    <dbReference type="PhylomeDB" id="E9HTL2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX64918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="387" mass="43723" checksum="920AFA45069B0DEC" modified="2011-04-05" version="1">MARNKKRDARYSKSRAVKEGGSRKRKRLAGDQEPVIDFDTVPEAQDREEEAVAVEEPVEEPVEEPVEEPDEEPVEEPDEEPGQELVASQRTELDQDPEIEDEPSASEDDEQKAGTEEEEPVVEPLTPKVVTVQLERLDLSPATLQRLKRVQKAKKRKEREDSSKSGSSPPKRTRSQTRRPISAGSSSETADPDGEVTRHYTGKKMPFLEFKRNVTMGLLSHALNENKNKAGRAGRMMPTIHPSAEPGAKRRKSRLSVRDDIRFTGVGLHLPIFGEARGRCEWCQITTKTKLESRPFSKCKQCNVFLCLGKKRNCFVEFHDENYLFEEEAPLAEVEAVYSASEESDGQASDHEPTNKECSSSSADSDELEDTNRREGFIIDEYDDFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9HWT2</accession>
    <name>E9HWT2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_334976</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX63802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX63802"/>
        <property type="gene ID" value="DAPPUDRAFT_334976"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_334976"/>
    <dbReference type="HOGENOM" id="CLU_002755_2_6_1"/>
    <dbReference type="InParanoid" id="E9HWT2"/>
    <dbReference type="OMA" id="MAFVGQM"/>
    <dbReference type="OrthoDB" id="828574at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="380" mass="41119" checksum="F56B6E9CA5ABCE59" modified="2011-04-05" version="1" fragment="single">MVVQAFWPGATAQQMAEQVTDKIEKTLQEVPLGDKILSSTKPGESLTVFQLKDDSAAKDVPEVWYQVRKRLGDMRGTLPQGVYGPFFNDEFGDVYGSIFALSADGFTPEELREYAERVRSQLLRVPDVTKVETFGAQPEKVFIEVSQKRLANLGLDFGQVINQLGAQNAVEGGGVLNAGAGNLQIRIGGQFNSVQALKDFAIRAINPMTGQASTLRLSDIAEVRRGYADPPSVMVRHQGKDVIALGVSMGKGGDIVAMGKALQKTAAAIRKTLPAGIELVQVQDQPQAVTRSVNEFVQVLLEAVVIVLAVSFIALGLHTRPLRVDIWPGLVVAITIPLVLAITFVTMFYWSVXLHKISLGSLIIALGLLVDDAIIAVEMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9HXS9</accession>
    <name>E9HXS9_DAPPU</name>
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        <recommendedName>
            <fullName evidence="1">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733069">
        <property type="protein sequence ID" value="EFX63451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX63451"/>
    <dbReference type="EnsemblMetazoa" id="EFX63451">
        <property type="protein sequence ID" value="EFX63451"/>
        <property type="gene ID" value="DAPPUDRAFT_17699"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_17699"/>
    <dbReference type="eggNOG" id="KOG0947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096089_0_0_1"/>
    <dbReference type="InParanoid" id="E9HXS9"/>
    <dbReference type="PhylomeDB" id="E9HXS9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="149" mass="16607" checksum="BF3192068FA13D32" modified="2011-04-05" version="1" fragment="single">AIIHLEKGEDVFIAAHTSAGKTVVAEYAIALSQKHMTRAIYTSPIKALSNQKFRDFKTTLPDVGLCDVKINAKATCLIMTTEILRSMLYNGSDIIRNLDWVIFDEVHYINDSERGVVWDEVLILLPSHVNIVMLSATVPNTSEFATWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HXV5</accession>
    <name>E9HXV5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_335484</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733079">
        <property type="protein sequence ID" value="EFX63428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63428">
        <property type="protein sequence ID" value="EFX63428"/>
        <property type="gene ID" value="DAPPUDRAFT_335484"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_335484"/>
    <dbReference type="HOGENOM" id="CLU_2415538_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019670">
        <property type="entry name" value="DUF2523"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10734">
        <property type="entry name" value="DUF2523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="92" mass="9868" checksum="AFB7C893F7651C9E" modified="2011-04-05" version="1">MPAVLAAVGVWIISSVIAKVLVALGIGLFTYYGLFGLVEELIDQLRFLLGDMPPAVFQIISLFGFPEGLSILCSAFLTRAAIQSTKVFFGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZ94</accession>
    <name>E9HZ94_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M41 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_67538</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733296">
        <property type="protein sequence ID" value="EFX62936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX62936"/>
    <dbReference type="MEROPS" id="M41.A12"/>
    <dbReference type="EnsemblMetazoa" id="EFX62936">
        <property type="protein sequence ID" value="EFX62936"/>
        <property type="gene ID" value="DAPPUDRAFT_67538"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_67538"/>
    <dbReference type="eggNOG" id="KOG0731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_13_0_1"/>
    <dbReference type="InParanoid" id="E9HZ94"/>
    <dbReference type="OMA" id="QIVANHE"/>
    <dbReference type="OrthoDB" id="1569115at2759"/>
    <dbReference type="PhylomeDB" id="E9HZ94"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M41" evidence="1">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX62936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="202" mass="22691" checksum="19F0D49339E0D1EE" modified="2011-04-05" version="1" fragment="single">NTDALLKVTIVPRTSQALGFAQYTPTDKRLFSTEKLFGRMCMALGGRVAESITFRVITGAQNDLHKVTKIAYSQVRTYGMNESMGPILFPDEDRNSREFGGRPYSKRLAITMDDETRNIIASAYKRTESILLQHRHMLEKMAEELLLKETLNLNFDVKALVGSPPHGQKQLIEPLQFEAEINEQAGIAPGRSQQQSPPLPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9I1W7</accession>
    <name>E9I1W7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_120635</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL733901">
        <property type="protein sequence ID" value="EFX62011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX62011"/>
    <dbReference type="EnsemblMetazoa" id="EFX62011">
        <property type="protein sequence ID" value="EFX62011"/>
        <property type="gene ID" value="DAPPUDRAFT_120635"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_120635"/>
    <dbReference type="eggNOG" id="KOG2514">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_480291_0_0_1"/>
    <dbReference type="InParanoid" id="E9I1W7"/>
    <dbReference type="OMA" id="CLMEFIN"/>
    <dbReference type="OrthoDB" id="1263362at2759"/>
    <dbReference type="PhylomeDB" id="E9I1W7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902476">
        <property type="term" value="P:chloride transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="PTHR12308"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Anoct_dimer" evidence="8">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX62011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="568" mass="65781" checksum="70628D1B9C44395E" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9I360</accession>
    <name>E9I360_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_272740</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Tang H."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
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    </reference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX61296"/>
        <property type="gene ID" value="DAPPUDRAFT_69956"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_69956"/>
    <dbReference type="HOGENOM" id="CLU_2967707_0_0_1"/>
    <dbReference type="InParanoid" id="E9I3Y4"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX61296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="59" mass="6568" checksum="790A2379A2A4ED43" modified="2011-04-05" version="1" fragment="single">DFADYITDQNVLGRLKQHGILKMFPVQEETFRLIEAGKDVLASDRTGSGKTLGYTLPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9I421</accession>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_015861_0_0_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Wolf Y.I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="OrthoDB" id="1313800at2759"/>
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    <proteinExistence type="predicted"/>
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    <feature type="non-terminal residue" evidence="1">
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        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX60249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX60249"/>
        <property type="gene ID" value="DAPPUDRAFT_344443"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_344443"/>
    <dbReference type="HOGENOM" id="CLU_2135952_0_0_1"/>
    <dbReference type="OrthoDB" id="1146281at2759"/>
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    </dbReference>
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            <dbReference type="EMBL" id="EFX60249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="113" mass="13129" checksum="B4C633C348A3284C" modified="2011-04-05" version="1">MQIAKLSQLPREWNPGVEIKFTDLVTLVLQDFKDYDQLKSECGGIQTLLRNYIFVVQNKCVRFRAPKELSVEEWRNQQKHTKATKISRLDTIGRLSLGNLTVSLPHWQPSLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9I706</accession>
    <name>E9I706_DAPPU</name>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL736847">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_344647"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_344647"/>
    <dbReference type="HOGENOM" id="CLU_1251766_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="221" mass="24876" checksum="C83276F6C73EA3C5" modified="2011-04-05" version="1">MEAFSERGLNFVTELKSKRKVRNGSGYNVPYKDLSEHFRKPHGEVYAKPLASKRGKGRPCLRFTETKVVQLKSYKSPIRVVALYNKRSSRRAFGYFASTDRTMPGATVWKFCRARWAIEVMFRDLKQNLSFGTLPCGGENASDLAVAMPFAIITSLRLRPEIWQVEAGLTIGSSISIVKDRALSRSIDLLGFECSVILRNRVRARRDAARSGRKPVDQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9I772</accession>
    <name>E9I772_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL737002">
        <property type="protein sequence ID" value="EFX60158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60158">
        <property type="protein sequence ID" value="EFX60158"/>
        <property type="gene ID" value="DAPPUDRAFT_345059"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_345059"/>
    <dbReference type="HOGENOM" id="CLU_971694_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="287" mass="31853" checksum="815C4637CF8389EE" modified="2011-04-05" version="1" fragment="single">MGRRGRSWGMGIFLDDGSKPFDTDASIFDGVTCDINIQKSQTLGFSVGYDKISETGGSILSTGARSSNYGPTNHGDDLDQFFLTIEYNDQRANVGRDFSKQIGIYFSNVIGGTETKTDVKFGDLYVNFIMQDLVFQNEVLFRLGRSADPNWSRLGSARTFNDTEDQVNNELQGIALAGSLEYFVSRGGAYVGPKDYNQGNATSHSLFVGYAYAPGDPDGYHPEYPSDDAPSARDKKVKAIAFHKNFKPALLLFNGRKRNDNLRIDGVFDPYRVMNATVFNTGYRYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9I7X2</accession>
    <name>E9I7X2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL737568">
        <property type="protein sequence ID" value="EFX59908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX59908">
        <property type="protein sequence ID" value="EFX59908"/>
        <property type="gene ID" value="DAPPUDRAFT_346475"/>
    </dbReference>
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                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90087"/>
    <dbReference type="EnsemblMetazoa" id="EFX90087">
        <property type="protein sequence ID" value="EFX90087"/>
        <property type="gene ID" value="DAPPUDRAFT_205349"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_205349"/>
    <dbReference type="eggNOG" id="KOG4788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090110_0_0_1"/>
    <dbReference type="InParanoid" id="E9FR29"/>
    <dbReference type="OMA" id="WFNTVAM"/>
    <dbReference type="OrthoDB" id="1520058at2759"/>
    <dbReference type="PhylomeDB" id="E9FR29"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="4">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX90087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="186" mass="20737" checksum="2710257961DA5AF4" modified="2011-04-05" version="1">MAETGFPGTYSTTTVTQTATTVTTNIRFDPSYIRTIPGMLKIAIMVLNILGFICVMVSEVNWHSRANWFNFCAMGGFWITGILLAFYLFHVIEKLYFVPWIMVVSTTEMGYCGLWCFFMLTASAACAAQGSLFEAWAAASFFGFISMIVYGVDAFFKFKGWRAGEIAQGERVRSVQKSETVGTPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRL8</accession>
    <name>E9FRL8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_39440</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90458"/>
    <dbReference type="EnsemblMetazoa" id="EFX90458">
        <property type="protein sequence ID" value="EFX90458"/>
        <property type="gene ID" value="DAPPUDRAFT_39440"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_39440"/>
    <dbReference type="eggNOG" id="ENOG502S3RD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163592_1_0_1"/>
    <dbReference type="InParanoid" id="E9FRL8"/>
    <dbReference type="OMA" id="RTMTFGV"/>
    <dbReference type="OrthoDB" id="1550606at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031305">
        <property type="term" value="C:integral component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial cytochrome c oxidase assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX90458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="97" mass="11664" checksum="4AF9F97DD6B04A59" modified="2011-04-05" version="1">MLHKLQRFFQKKSVKYSIPFLVLVVGGSFGLKQFTENRYDVFYMNFLDKEEAEKWGILKKDKSEVTLETEFEKVKQVSLIDWENKRGPRPWEQVTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSD0</accession>
    <name>E9FSD0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_303089</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89856"/>
    <dbReference type="EnsemblMetazoa" id="EFX89856">
        <property type="protein sequence ID" value="EFX89856"/>
        <property type="gene ID" value="DAPPUDRAFT_303089"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303089"/>
    <dbReference type="eggNOG" id="KOG1583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033007_1_0_1"/>
    <dbReference type="InParanoid" id="E9FSD0"/>
    <dbReference type="OMA" id="NYAFDFN"/>
    <dbReference type="OrthoDB" id="1209974at2759"/>
    <dbReference type="PhylomeDB" id="E9FSD0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030176">
        <property type="term" value="C:integral component of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030173">
        <property type="term" value="C:integral component of Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="UAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="PTHR10778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX89856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="335" mass="37292" checksum="A3B1FAA8DC036B25" modified="2011-04-05" version="1">MKSLIAGLLVFVGCCSNVFFLELLIKEDPGSGNLITFAQFLVIAVEGFITTMRFGTKKTQVPFTEYLKMVLMFFVVSVTNNYALSFNIALPLHMIFRAGSLLANMVLGILILKKRYTAMKYLSVFMISVGICVCTIASAKELSHSDSENQITSFGDFVWWIVGISLLTFALFMSARMGIMQEVMYSKFGKHPREALFFTHALPLPGFLLLFTDISKHIGVANMSAPLDSTVLSVIPLLNVLPRMWIYLLGNVLTQSVCINAVFVLTTECSSLAVTLIVTLRKFVSLLFSIWYFQNPFTLLHWFGTVLVFGGTLVFGFGIPGLMRQSKSKPKSKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9FST5</accession>
    <name>E9FST5_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_303127</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89764"/>
    <dbReference type="EnsemblMetazoa" id="EFX89764">
        <property type="protein sequence ID" value="EFX89764"/>
        <property type="gene ID" value="DAPPUDRAFT_303127"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303127"/>
    <dbReference type="eggNOG" id="KOG1917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004450_0_0_1"/>
    <dbReference type="InParanoid" id="E9FST5"/>
    <dbReference type="OMA" id="VGMVMYN"/>
    <dbReference type="OrthoDB" id="138196at2759"/>
    <dbReference type="PhylomeDB" id="E9FST5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019137">
        <property type="entry name" value="Nck-associated_protein-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12093">
        <property type="entry name" value="PTHR12093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09735">
        <property type="entry name" value="Nckap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX89764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1120" mass="127792" checksum="86028239395E1ECB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9FT17</accession>
    <name>E9FT17_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_233047</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89723">
        <property type="protein sequence ID" value="EFX89723"/>
        <property type="gene ID" value="DAPPUDRAFT_233047"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_233047"/>
    <dbReference type="HOGENOM" id="CLU_2225835_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="106" mass="12035" checksum="94B6CF6802ED57FE" modified="2011-04-05" version="1">MEIWIGVWSRINLNVRLHFNIHWPPPPGDTQTVSRVAVAWLEQSPEKDLPIEFYFDFADKIYSHPAPTQTGPCGWTTRKHKTTTTTTVRGIPVPRPFARNNGPGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9FVI5</accession>
    <name>E9FVI5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Purinergic receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_206200</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the P2X receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX89098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89098"/>
    <dbReference type="EnsemblMetazoa" id="EFX89098">
        <property type="protein sequence ID" value="EFX89098"/>
        <property type="gene ID" value="DAPPUDRAFT_206200"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_206200"/>
    <dbReference type="eggNOG" id="ENOG502QSUI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034469_2_0_1"/>
    <dbReference type="InParanoid" id="E9FVI5"/>
    <dbReference type="OMA" id="VFSWCPL"/>
    <dbReference type="OrthoDB" id="1128763at2759"/>
    <dbReference type="PhylomeDB" id="E9FVI5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005639">
        <property type="term" value="C:integral component of nuclear inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004931">
        <property type="term" value="F:extracellularly ATP-gated cation channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001614">
        <property type="term" value="F:purinergic nucleotide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033198">
        <property type="term" value="P:response to ATP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003045">
        <property type="entry name" value="P2X2_purnocptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027309">
        <property type="entry name" value="P2X_extracellular_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001429">
        <property type="entry name" value="P2X_purnocptor"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005713">
        <property type="entry name" value="P2X_purinoceptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01309">
        <property type="entry name" value="P2X2RECEPTOR"/>
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        </location>
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        </location>
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        </location>
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        </source>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <location>
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            <end position="40"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <accession>E9FWS8</accession>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX87947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87947">
        <property type="protein sequence ID" value="EFX87947"/>
        <property type="gene ID" value="DAPPUDRAFT_234512"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_234512"/>
    <dbReference type="HOGENOM" id="CLU_1688533_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX87947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="156" mass="17795" checksum="B6BA00028835608B" modified="2011-04-05" version="1">MTVSFMATRLTTYGRNLPTIQYNNQSNAPYSTLAVVVVACDSQMTKDLLVLLGDPSRAAFAARIPTPSSKCQNHRLLLENQNCLWMYFTNTWRMRTKKQTNPSLARRRLAGWLAEYPLSGERLPPPTSNKTKKRNKAPSKTPTQYERFGNKFFDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9FX33</accession>
    <name>E9FX33_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_42083</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88331"/>
    <dbReference type="EnsemblMetazoa" id="EFX88331">
        <property type="protein sequence ID" value="EFX88331"/>
        <property type="gene ID" value="DAPPUDRAFT_42083"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_42083"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009579_11_1_1"/>
    <dbReference type="InParanoid" id="E9FX33"/>
    <dbReference type="OMA" id="GIGDREM"/>
    <dbReference type="OrthoDB" id="1095345at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004935">
        <property type="term" value="F:adrenergic receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004989">
        <property type="term" value="F:octopamine receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002233">
        <property type="entry name" value="ADR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01103">
        <property type="entry name" value="ADRENERGICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F1_2" evidence="9">
        <location>
            <begin position="68"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX88331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="492" mass="54481" checksum="EB3C8220B5777AC5" modified="2011-04-05" version="1">MAGLHLLDSVASGVTSDGEIANNDSWPTVTAAAVGNCSNPLEEVDWSQPGLIISLVILGVVNVLVLFGNCLVVLAVFLDSKLRTVTNLFIVSLAMADLSVGLAVLPFSASLEVLDMWIFGEIWCSIWLAVDVWMCTASILNLCAISLDRYLAVTRPVSYPSIMTPFRAKILLAVVWLLSFVICFPPLVGWNDRKINRHPSQQHCDDWSCELTNDPGYVVYSALGSFFIPMLVMLFFYWRIYRAAVETTKAINQGFRTTKCVENKERLTLRIHRGRSGQKPGTNGRASKAGNNKRSALEIFQTGGNHGKKNNRSKYNNGGHRCLSPRMSGGVDDGVDPLGSANNHNNAKPLKMNRRSNIKAQVKRFKMETKAAKTLGIIVGGFIVCWMPFFTMYVVRAFCPQCIPSVLFSVLFWLGYCNSAINPCIYALFSRDFRYAFQKIVCQCLCTRRSHAQHLSIIKMMVPQGMIAGLGSAAFNTDDSDPYANDHSDQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXI3</accession>
    <name>E9FXI3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_305522</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88262">
        <property type="protein sequence ID" value="EFX88262"/>
        <property type="gene ID" value="DAPPUDRAFT_305522"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305522"/>
    <dbReference type="HOGENOM" id="CLU_1391514_0_0_1"/>
    <dbReference type="InParanoid" id="E9FXI3"/>
    <dbReference type="OrthoDB" id="1813139at2759"/>
    <dbReference type="PhylomeDB" id="E9FXI3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240423" evidence="3">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX88262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="211" mass="23201" checksum="8BC3D8E539FA7438" modified="2011-04-05" version="1">MISIVILACLATMAMSAPTETKTVINVDGPDGHHVQTGEPGKAVSGYFTSRNSDGVEEKTIYEADERGFRATGAHLPVAPGVFPVQRYSAFPSVYPVAPVLPSYGYRYAPENYYPYYYPSFVSGKYGSAKDYLSSIYDGGYRTGEDFSELSMTREEMAEAEEQLEQITPEELAVLTERGPLTPFFLPMILANKKNIIMMMIANKILTAMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXS3</accession>
    <name>E9FXS3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein DpuGr10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DpuGr10</name>
        <name evidence="5" type="ORF">DAPPUDRAFT_346840</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88237">
        <property type="protein sequence ID" value="EFX88237"/>
        <property type="gene ID" value="DAPPUDRAFT_346840"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_346840"/>
    <dbReference type="HOGENOM" id="CLU_058520_0_0_1"/>
    <dbReference type="InParanoid" id="E9FXS3"/>
    <dbReference type="OrthoDB" id="901124at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="PTHR21143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX88237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="421" mass="47937" checksum="A7B23D7ABC1ADD5B" modified="2011-04-05" version="1">MCALGHLSTDIINQSSQQVAALLPTVERNMLRKRVARQVSCSSDEETMMSFKWCCRPVLIVTNIFGIPLKMKEDEPSYSAWMVYIFGWILYCTNVAIGLIIIILCQDAGNVSSLSPDSEEFNNSTTASRWNEGISTYNTISSMIATHTVLLAVTAVRWEDLVRVLDRMERTNQFNLKEFSVFRAIFHVGFVFAVIGCLATGLLSISTYFTIDLQLWQMLIFAVQRWLILYILLAVLLFTCFGWMAATMLQMVGKEMELIQENGQLHENCDGPVDVLISKCSRHYFVTIDFIHQFNGCFGCLLLVLIAPAFIRIINASFQLMINLKDGHWTMDMIVQFMILLVHCVLFTLTFNLTKKLRKLYFDDFSLQNQVNVLIMEISNSVPKITAAGFFDVDLQLIPTLVGTTLTYLIILFQFQTSEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYX4</accession>
    <name>E9FYX4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Tyrosine aminotransferase</fullName>
            <shortName evidence="11">TAT</shortName>
            <ecNumber evidence="6 11">2.6.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DAPPUDRAFT_306563</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2-oxoglutarate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15093"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="2.6.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.5" evidence="6 11"/>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87697"/>
    <dbReference type="EnsemblMetazoa" id="EFX87697">
        <property type="protein sequence ID" value="EFX87697"/>
        <property type="gene ID" value="DAPPUDRAFT_306563"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306563"/>
    <dbReference type="eggNOG" id="KOG0259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_2_1"/>
    <dbReference type="InParanoid" id="E9FYX4"/>
    <dbReference type="OMA" id="WRMGWII"/>
    <dbReference type="OrthoDB" id="734452at2759"/>
    <dbReference type="PhylomeDB" id="E9FYX4"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004838">
        <property type="term" value="F:L-tyrosine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005958">
        <property type="entry name" value="TyrNic_aminoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005957">
        <property type="entry name" value="Tyrosine_aminoTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000517">
        <property type="entry name" value="Tyr_transaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01264">
        <property type="entry name" value="tyr_amTase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01265">
        <property type="entry name" value="tyr_nico_aTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="9 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="13">
        <location>
            <begin position="38"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000517-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFX87697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="439" mass="48664" checksum="57B4F0AD92BDE81E" modified="2011-04-05" version="1">MKSRRSWSVTASDLARNTFNPIRTVVESMKLTPNPEKPMIALSIGDPTIFGNLCPSEEIVEAVVESVRSMKYNGYAPSTGYEESRKVVASYVSVPGAAVEAKDIILCSGCSCALDLCISVLANPGQNILVPRPGFPLYRTLAEGLGIRTKFYDLKPENGWEVDLEQLEAQIDDQTAAIVLNNPSNPCGSVYSREHLSAILQIAARNFVPIIADEIYDYFVFPGHEFHPVASLTNEVPILTCGGLTKRYLIPGWRMGWIVVHDRNEALSQEVRKGLQSLSQRIIGSSTVLQGALSRILTQTPPEFFQSTIGQVYDNAQLAHQLLSGLPGMKPIMPSGAMYMMVGVDMANFPEFENDLQFVERMVTEQSVFCLPGRCFDYPNYFRIVLTVPELQLREACHRIGQFCTSHFVAPINLGKEEAMSNSHIHHELHNGIVTIIEP</sequence>
</entry>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3126490_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX86666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="50" mass="5663" checksum="1820906D43A98F81" modified="2011-04-05" version="1">MIAKSRLRVAQQTSIQHPVVLAGLLFISYAALLEWSKQLPDLNTSKIRQK</sequence>
</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX85667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85667">
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        <property type="gene ID" value="DAPPUDRAFT_98614"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2006149_0_0_1"/>
    <dbReference type="OrthoDB" id="1357584at2759"/>
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    <dbReference type="Proteomes" id="UP000000305">
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        <source>
            <dbReference type="EMBL" id="EFX85667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="124" mass="13707" checksum="3F139993B70A377D" modified="2011-04-05" version="1">MNAKELQCERVPTVANISTRCTNTNVVNFVLGSMELAQVAVTGLLRCLDISLEEYLWGIVTHTRVNLQTGRPVCPDRMSFSLEGHEKHYVKLACDGVEVGSIPSNVILQKERPVCMSIEGHGDH</sequence>
</entry>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1549178_0_0_1"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EFX84788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="173" mass="18805" checksum="CEDB4A1E378CEC97" modified="2011-04-05" version="1">MLRKIWNSPTPVCQIDVKNETNDASSFFGTLSDCHDEESTYLLDIAVMVVHCGVRLFSAERTLNVKNHNRILNIAVQVSGVNRNAYYTTVETKASDVQASDIQATGLNGRHSDQCQGTFRPMLMTQATGLNVAGLNVTGLNVRDPTKLSASLVAGGANARLHLLSHNFFDTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7H2</accession>
    <name>E9G7H2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="2">
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        <name type="common">Water flea</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84642">
        <property type="protein sequence ID" value="EFX84642"/>
        <property type="gene ID" value="DAPPUDRAFT_238817"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238817"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX84642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="55" mass="6567" checksum="F22E43F2BA034F71" modified="2011-04-05" version="1">MEQLGPISVQRFEEESGIKIDFQTLQRRISYCSKREWFEVAILIFAIDERHHATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9A4</accession>
    <name>E9G9A4_DAPPU</name>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name evidence="3" type="ORF">DAPPUDRAFT_100090</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX84103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX84103"/>
        <property type="gene ID" value="DAPPUDRAFT_100090"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_100090"/>
    <dbReference type="HOGENOM" id="CLU_1697294_0_0_1"/>
    <dbReference type="OrthoDB" id="1809679at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012858838" evidence="2">
        <location>
            <begin position="16"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX84103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="155" mass="17145" checksum="67C4645E34E2F041" modified="2011-04-05" version="1">MNPVVVLLLVQLVAAQPVALSNPFAGWNTKPSSSKVAVLDTQPLSRTRSLPQTSQSTNGNHAGPVNTKNGGTFDKVGKIMTTTTTTEPSTQQATVDIETLPGFWLKDPSRIEETTGSSYEVDYRTERYRLDDLLLLNKRRKNGYVGHHHEDEKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Daphnia pulex</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX83368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_301882"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301882"/>
    <dbReference type="HOGENOM" id="CLU_1442448_0_0_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="EFX83368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="188" mass="21701" checksum="37B2E2D427EBCF60" modified="2011-04-05" version="1">MEFQIIKNGQICGGKNEMRDEVFSSGQNIFHFPFACSFFDSMPSPFFSFPISLKETLLLLLLAVDRLLLGTQSNLFRLISLFQTARAPQSTVGGAQLLFKKGETRWAITSETVSSHVPFPSFFLLLTKKKKSSLARPLYYYYRRDACDINSRDVIAQQSKPTRRVPEYRNIRDIRAKFLLTKLLHHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDJ4</accession>
    <name>E9GDJ4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_302591</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82466">
        <property type="protein sequence ID" value="EFX82466"/>
        <property type="gene ID" value="DAPPUDRAFT_302591"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302591"/>
    <dbReference type="HOGENOM" id="CLU_765628_0_0_1"/>
    <dbReference type="OrthoDB" id="1741436at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX82466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="362" mass="40991" checksum="C6121CF7F09CE88C" modified="2011-04-05" version="1">MDYIVLGTMLVVLLVILTVTLNKYKLSSNHRRKYKKLKSNLYTLTKKVEEQHKVIGRLDSCLAQQNEKITRHDIEKMKDFGSDFAQGVKITSLKEAVQHIFGRSEKNVEDQHVIIECSKIRDVLRPSDGANNSDYVTGIQRDLLIWYLEGVRGYRLKSPSELEDKLRRFPWVGEDGKLSLVNVRKCIRFVHKDLKQTLAFLAQTIDWDDLNSFISPRPKKGKAKGHGLYFLMHHLYASHCRATSATAHKPQSLFSFPPPGEIEIDAQGRIETGPGTIKIKMGEIKISKEKIPEAKKQLKRSLVFFAGLHKLIAVNDDVSPCASPICYDLIGYIFISGGTNVTKTEVLPLPPLGKISYLIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEE4</accession>
    <name>E9GEE4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_241495</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82328">
        <property type="protein sequence ID" value="EFX82328"/>
        <property type="gene ID" value="DAPPUDRAFT_241495"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241495"/>
    <dbReference type="HOGENOM" id="CLU_2690316_0_0_1"/>
    <dbReference type="OrthoDB" id="830428at2759"/>
    <dbReference type="PhylomeDB" id="E9GEE4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX82328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="74" mass="8207" checksum="BA395B8E15F87EBD" modified="2011-04-05" version="1">MFNQWTTEKVKAESVNVLPKAYVEAAILEDDEVALTLNDGQKAGDVAFFCDSKLGRRRMAHHHHAVVSGLNINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEM1</accession>
    <name>E9GEM1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="4 6">2.4.1.135</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_49588</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>3-O-(beta-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:24168"/>
            <dbReference type="Rhea" id="RHEA-COMP:12571"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132090"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="EC" id="2.4.1.135"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glycosyltransferase 43 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.135" evidence="4 6"/>
    <dbReference type="EMBL" id="GL732541">
        <property type="protein sequence ID" value="EFX82059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX82059"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_49588"/>
    <dbReference type="eggNOG" id="KOG1476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045177_3_0_1"/>
    <dbReference type="InParanoid" id="E9GEM1"/>
    <dbReference type="OMA" id="HVYLATT"/>
    <dbReference type="OrthoDB" id="901158at2759"/>
    <dbReference type="PhylomeDB" id="E9GEM1"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015018">
        <property type="term" value="F:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00218">
        <property type="entry name" value="GlcAT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005027">
        <property type="entry name" value="Glyco_trans_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896">
        <property type="entry name" value="PTHR10896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03360">
        <property type="entry name" value="Glyco_transf_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX82059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="248" mass="28052" checksum="242AD45A5F3E8108" modified="2011-04-05" version="1" fragment="single">PVIYLVTPTYRRPEQIPDLTRLAQTLLNVPAVHWIVVEDSSTLSPAIASLLKRYGIPHTHLKAQMPEKYKKSKLKPRGVANRNAALDWVRSNCKSGVVYFADDDNTYDIRLFEEMRFTKKVSMWPVGLVTKVGLSSPVVNDKGLVVDFFDGWMANRKFPVDMAGFAVSVQLVLEKSDVYMPYVPGHEEDGFLKKLDITPADIEPKADRCTQIFVWHTQTKSNSPANRTTAAGKRYKGTNIDILQEWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEP7</accession>
    <name>E9GEP7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_302773</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732541">
        <property type="protein sequence ID" value="EFX82042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82042">
        <property type="protein sequence ID" value="EFX82042"/>
        <property type="gene ID" value="DAPPUDRAFT_302773"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302773"/>
    <dbReference type="HOGENOM" id="CLU_2981161_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX82042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="58" mass="6582" checksum="32A1FA5DF9DF7FBB" modified="2011-04-05" version="1">MQYVCSITIGWNVWTVIAGFAHCRIVLNVKSVIAAHGWITFDTLSLTWISSVYSMYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9GFN5</accession>
    <name>E9GFN5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_317331</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX81665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX81665"/>
        <property type="gene ID" value="DAPPUDRAFT_317331"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_317331"/>
    <dbReference type="HOGENOM" id="CLU_1112279_0_0_1"/>
    <dbReference type="InParanoid" id="E9GFN5"/>
    <dbReference type="OMA" id="QIVYIPA"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240952" evidence="2">
        <location>
            <begin position="26"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX81665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="250" mass="22703" checksum="1FC3D0F9729B73D0" modified="2011-04-05" version="1">MAKVNMNTLKCFLLFGLVLVHGTDATKGKGRGGGGYGATPPQIVYIPAPQPVYIPAPQPIHHAPPPPRPAPVPSYGGGGGYRAPGGSGGAPVHVHVHSAPVHQSAPSYGGGAGYGGASGGGHSSGGYGGASGGGHSSGGYGGASGGGHSSGGYGGASGGGHSSGGYGGASGGGHSSGGYGGASGGGHSSGGYGGASGGGHSSGGYGGASGGGHSSGGYGGAPEAGYASAPSFQPPPVSSYGPPPPQGGGY</sequence>
</entry>
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    <accession>E9GG99</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX81533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81533">
        <property type="protein sequence ID" value="EFX81533"/>
        <property type="gene ID" value="DAPPUDRAFT_242278"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_242278"/>
    <dbReference type="HOGENOM" id="CLU_1742408_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="150" mass="17026" checksum="CF53A2D80AD33A37" modified="2011-04-05" version="1">MDIDVVKHFLKFLYTGCLEISATIKQLRELAKMYEMETLMEICQLANCSPDATSKLDASKIYFLDKPSAFPFRVNLRVVNHFLSFRRTGDFDLDNWTHSPGGFGDASANIEQMTALAKMYDVGPFNKICQLDRSVPLDLDEITTFLLTAL</sequence>
</entry>
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    <accession>E9GGU4</accession>
    <name>E9GGU4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732544">
        <property type="protein sequence ID" value="EFX81300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81300">
        <property type="protein sequence ID" value="EFX81300"/>
        <property type="gene ID" value="DAPPUDRAFT_242510"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_242510"/>
    <dbReference type="HOGENOM" id="CLU_1490497_0_0_1"/>
    <dbReference type="InParanoid" id="E9GGU4"/>
    <dbReference type="OrthoDB" id="222689at2759"/>
    <dbReference type="PhylomeDB" id="E9GGU4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="181" mass="20310" checksum="94488BAB49997296" modified="2011-04-05" version="1">MYCQKLTSPPFPQVAASLPANTLRDVRAFEITGTDFAGPLYYKNATPKRKSKSAPSVEQVIPEPPPEEENPDAAEPPTEEAPEEEDDVDQSDPAQQVNKKQPKSYVCIFTCVVTRAIHLELTKDVTARSFLLAFRRFSARRGSVSVMYSDNAQTFRCVSRYLKNIRSDPSVHDLLAMRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIA3</accession>
    <name>E9GIA3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small monomeric GTPase</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_318262</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="EMBL" id="GL732546">
        <property type="protein sequence ID" value="EFX80641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80641"/>
    <dbReference type="EnsemblMetazoa" id="EFX80641">
        <property type="protein sequence ID" value="EFX80641"/>
        <property type="gene ID" value="DAPPUDRAFT_318262"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_318262"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="InParanoid" id="E9GIA3"/>
    <dbReference type="OMA" id="IEDCFRT"/>
    <dbReference type="OrthoDB" id="1353024at2759"/>
    <dbReference type="PhylomeDB" id="E9GIA3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032486">
        <property type="term" value="P:Rap protein signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04176">
        <property type="entry name" value="Rap2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041840">
        <property type="entry name" value="Rap2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="PTHR24070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX80641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="194" mass="21954" checksum="17DA1B3AEFCE72C7" modified="2011-04-05" version="1">MNARTTRSAKNQKMREFKVVVLGSGGVGKSALTVQFVTGCFMEKYDPTIEDFYRKEIEVDGSPSVLEILDTAGTEQFASMRDLYIRNGQGFVIVYSITNHQTFQDIKTMREQITRVKGTDRVPLLLVGNKVDLEHQREVATMEGLALAQAWNCPFIEASARNKMNVNEVFAEIVREMNCNPAKEKRPYCCCNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIL0</accession>
    <name>E9GIL0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_303873</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732546">
        <property type="protein sequence ID" value="EFX80733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80733"/>
    <dbReference type="EnsemblMetazoa" id="EFX80733">
        <property type="protein sequence ID" value="EFX80733"/>
        <property type="gene ID" value="DAPPUDRAFT_303873"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303873"/>
    <dbReference type="eggNOG" id="KOG1027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_7_1_1"/>
    <dbReference type="InParanoid" id="E9GIL0"/>
    <dbReference type="OMA" id="HFNISCE"/>
    <dbReference type="OrthoDB" id="672565at33208"/>
    <dbReference type="PhylomeDB" id="E9GIL0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="PTHR13954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX80733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="305" mass="34480" checksum="B929B0F823A7EE4E" modified="2011-04-05" version="1">MDKTKIVSDSLSYDDNEILGKGTAGFVFRGSFGLDKNPVAVKRVQLASLRKDEDFQKREEDALASLDHPNVVKLFHAEDDLTFRYYVLELCAASLDQCFLPDRDLRKYKGALPSDQEVLLQMAKGLQYIHSMNLVHRDIKPENMMISITQPVHIKLADFGLCKPVNQRGTFSISGIKGTQYWMAPEILALEDQPYNKNDVEGANKGRGTMRSDIFALGLVYFTFLTNGLHLFGSKNLIISNVMRGKPNPANQSRLDQNHFAREIISNMTKSKPEDRIPLTEVIDMFRPPVHQSSPAFRIEDSESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJH8</accession>
    <name>E9GJH8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_318667</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Basu M.K."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_51651"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_004416_3_1_1"/>
    <dbReference type="PhylomeDB" id="E9GK63"/>
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    <proteinExistence type="predicted"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="78" mass="8816" checksum="4D61D432D885614D" modified="2011-04-05" version="1">MEGAKPFKIGFYYGPSKPDDPNDYLRHFHIEITNLIENGCQYKESNLKIEIAGLCCDAPALSFIKLVKSCGAYYCCMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9GL72</accession>
    <name>E9GL72_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_104074</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SID1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732550">
        <property type="protein sequence ID" value="EFX79805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79805">
        <property type="protein sequence ID" value="EFX79805"/>
        <property type="gene ID" value="DAPPUDRAFT_104074"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_104074"/>
    <dbReference type="eggNOG" id="ENOG502QUXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059625_0_0_1"/>
    <dbReference type="InParanoid" id="E9GL72"/>
    <dbReference type="OMA" id="RECGTIS"/>
    <dbReference type="OrthoDB" id="139174at2759"/>
    <dbReference type="PhylomeDB" id="E9GL72"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051033">
        <property type="term" value="F:RNA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050658">
        <property type="term" value="P:RNA transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025958">
        <property type="entry name" value="SID1_TM_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12185">
        <property type="entry name" value="PTHR12185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13965">
        <property type="entry name" value="SID-1_RNA_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX79805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="430" mass="50103" checksum="A0DFA755D41ED8B8" modified="2011-04-05" version="1">MSDASSDLNVIRTKKFLVVADLSHKGSGSHVKNSWLYKRHLWIASFLIIIVSLFYALPVIQLVTIYQNMMNDTGDQDLCYFNFLCAHPRWNFTDFNHIYSNLGYILLGILFYVSTSHRKFLRRKLSKENRNRLEENYGIPQHYGLFYAMGTALVVEGILSACYHICPTRANFQFDTTFMYVICILCTLKIYQSRHPDINAEAQEAFKVLAAVAVICVFSLFIEDMLVFQICVFFIHLLACLAISARVYYMGTWKMNFGVFKRIYCVLRNDFKAGLSNWCRPMYVDRMTLLVIGMLTNMCWAIYGLVYRPPDFASYMLGILVTNLFLYFTFYIFMKVWHGEKILCHAIFHMVCAFIIGIPAMYFFINNAATWSKTAAESRVFNRECQVLSFYDNHDIWHFLSAGSLFFFFMTLLTLDDDLAYTPRDKIAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GM46</accession>
    <name>E9GM46_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_319558</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732552">
        <property type="protein sequence ID" value="EFX79301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79301">
        <property type="protein sequence ID" value="EFX79301"/>
        <property type="gene ID" value="DAPPUDRAFT_319558"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_319558"/>
    <dbReference type="HOGENOM" id="CLU_1039220_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX79301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="268" mass="30662" checksum="52DDF7F4AEF9477C" modified="2011-04-05" version="1">MFEMLQLNSAKQALVDVMVEGKPVKTSKRNLEIDSFPEGARKLLNKRKSTQFGVKKHWYELSIMMFYKFSEETKKVQPHGKPDVIGSCIFCGKEITGQIVLIRNWKNHLQNCHQDIPEWKEYIKKTLEIKEQRRRNSSGLVPSSIMSMQKQSRVQHTLGSHTLSPQPLLRMMPTTHCLKEVRDMTSSPSLQESFKQRKTSPLLSLALKEESVAFSRPDSTISECCMIEETDLPNIKSDSSSIHRTIQTRGQSKRLGALQVSKTGHLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9GM56</accession>
    <name>E9GM56_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit s, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase-coupling factor B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Distal membrane arm assembly complex 2-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Mitochondrial ATP synthase regulatory component factor B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DAPPUDRAFT_244919</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer. Associates with ATP synthase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP synthase subunit s family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732552">
        <property type="protein sequence ID" value="EFX79304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
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    <reference evidence="1 2" key="1">
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                <person name="Thomas W.K."/>
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                <person name="Thomas W.K."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732567">
        <property type="protein sequence ID" value="EFX76701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76701"/>
    <dbReference type="EnsemblMetazoa" id="EFX76701">
        <property type="protein sequence ID" value="EFX76701"/>
        <property type="gene ID" value="DAPPUDRAFT_248678"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_248678"/>
    <dbReference type="eggNOG" id="KOG1951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1327574_0_0_1"/>
    <dbReference type="InParanoid" id="E9GUZ9"/>
    <dbReference type="OrthoDB" id="463678at2759"/>
    <dbReference type="PhylomeDB" id="E9GUZ9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="PTHR12858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AARP2CN" evidence="2">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX76701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="207" mass="23798" checksum="03DE3F9BA53EA7A6" modified="2011-04-05" version="1">MAILNFSTSVREQNCFTSGQLHGTYPKNEIKNLGRFISVRKFRPLLWRLTLPYVLVDRLEYMTPPSRLDENPKCNRDIFLYGFVRGVHLRNQCPVHIPGCGDFRLKYKRSLVEKKKLIYAPMSGVGGIIYDKDSIYIELGGSHSHSKQEDPTNPKSEMISSLMKLQRTLDAQMCESRGEGPTLTQAHDEDEELLDDDGDVSYKREIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9GX54</accession>
    <name>E9GX54_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_107459</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732572">
        <property type="protein sequence ID" value="EFX75922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75922">
        <property type="protein sequence ID" value="EFX75922"/>
        <property type="gene ID" value="DAPPUDRAFT_107459"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_107459"/>
    <dbReference type="HOGENOM" id="CLU_547758_0_0_1"/>
    <dbReference type="InParanoid" id="E9GX54"/>
    <dbReference type="OrthoDB" id="325426at33208"/>
    <dbReference type="PhylomeDB" id="E9GX54"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040564">
        <property type="entry name" value="CxC3-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18804">
        <property type="entry name" value="CxC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC3" evidence="2">
        <location>
            <begin position="129"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX75922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="498" mass="57196" checksum="133DFBB4BCCA737F" modified="2011-04-05" version="1">MDHHVHHISTQTQSASYAGIVTANIEEYERIQSIISQMTEEVIMSVDNSHIDDQPHPLASSRTWQERQQSNKETWEKKEILLSQIIKCDFNIHMTEPFHRRYVVTSNETMKSLLPSEFFDSNWRPELKEIAVPCFVPSLCMNCGSSQMILKPGSNHIAVVNQHGRFDLRSASFYCGGCNLSFEAGLDDYIYSGLWPGLPCVGSYLFDEELLFLYYQTQHLSPGTSEKKFVKSLEEISSRAGRIGTINRPLFSMAYREWEFCTHRIEVDIKKMKKTSCPACGSNPLTGSCDGCMKLRRLQSAGEARKGKNTRERVNPKKCVADPKIVDTWMLWRRYQEEIIQTKLEILNYLNSLKASRISLEKQVLVDLEAADNTPFPDNERIRDFYRGKALIANTEVMRLSAKFSDAFHIFKLDSNFGLHATYFTEDLDFDVGLLEPDEGEDSDSESDYDSADELTDEEEDELTVDEDDEVESCEEDEHGSCEESDSFDDPYQFHEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYX7</accession>
    <name>E9GYX7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Beta-glucuronidase</fullName>
            <ecNumber evidence="3 7">3.2.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_306840</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 7">Plays an important role in the degradation of dermatan and keratan sulfates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:17633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:83411"/>
            <dbReference type="EC" id="3.2.1.31"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Inhibited by L-aspartic acid.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.31" evidence="3 7"/>
    <dbReference type="EMBL" id="GL732576">
        <property type="protein sequence ID" value="EFX75232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75232"/>
    <dbReference type="EnsemblMetazoa" id="EFX75232">
        <property type="protein sequence ID" value="EFX75232"/>
        <property type="gene ID" value="DAPPUDRAFT_306840"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306840"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006501_6_1_1"/>
    <dbReference type="InParanoid" id="E9GYX7"/>
    <dbReference type="OMA" id="WGILNEC"/>
    <dbReference type="OrthoDB" id="653343at2759"/>
    <dbReference type="PhylomeDB" id="E9GYX7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019391">
        <property type="term" value="P:glucuronoside catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
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        </location>
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            <begin position="193"/>
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        </location>
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    </evidence>
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        <source>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="143" mass="16213" checksum="97C0CE1C9D98AD28" modified="2011-04-05" version="1">MLRRINQRDIKKGCQPDGLFEIGTSSIPKRNGLAELDVSFASREIIEAKNVCASAVYQKLILRGYMTCGCEPQFHLAENAVEWERKASLGGYQYGTSKSTILQNQPARHKKKDANLIAFLKLAQALFRRGMVHHFSYYMEQAT</sequence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Choi J.H."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732590">
        <property type="protein sequence ID" value="EFX73498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX73498"/>
        <property type="gene ID" value="DAPPUDRAFT_253070"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_072898_1_0_1"/>
    <dbReference type="PhylomeDB" id="E9H441"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX73498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="152" mass="17921" checksum="0E9A367F338E84D8" modified="2011-04-05" version="1">MLEGYYVQLKTVAIKISKEAENSKTRTKMRRILTETKKKALETIELLNSKDEDLEIYYENFNKGVFPWEAAINENDTQFPTLSYADKYHVVDCWMLLQRANEEVILTKNEMINYVRFLTEKQLEFETSEEETENSTTELYSSSEEQETLSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5H6</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">DAPPUDRAFT_325765</name>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732594">
        <property type="protein sequence ID" value="EFX72960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72960">
        <property type="protein sequence ID" value="EFX72960"/>
        <property type="gene ID" value="DAPPUDRAFT_325765"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_325765"/>
    <dbReference type="HOGENOM" id="CLU_2266418_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX72960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="103" mass="11589" checksum="04467C51A0826EA8" modified="2011-04-05" version="1">MDSGASKSDDGQTQTVIAGWKNMDKYTHNTISAQPQPMTKISSNDGISCRFLPFMLSHQGNSIFKVISLMTQSLINPRVFASVQYAEQHQRICDWLFVFLKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5J5</accession>
    <name>E9H5J5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_325779</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732594">
        <property type="protein sequence ID" value="EFX72971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72971">
        <property type="protein sequence ID" value="EFX72971"/>
        <property type="gene ID" value="DAPPUDRAFT_325779"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_325779"/>
    <dbReference type="HOGENOM" id="CLU_718174_0_0_1"/>
    <dbReference type="InParanoid" id="E9H5J5"/>
    <dbReference type="OrthoDB" id="1605767at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033182">
        <property type="entry name" value="MIC26/MIC27_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14564">
        <property type="entry name" value="PTHR14564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237785" description="MICOS complex subunit" evidence="8">
        <location>
            <begin position="20"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX72971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="385" mass="41053" checksum="B06C8F0208797939" modified="2011-04-05" version="1">MNSFMMLSSAAFGLPVVHAKVAANSADSVDSKNCAAKVKVSSIPLYPEPVSWEYSAKPASQLEELVKKTRIEVTNTKAEYQPVLDKITHVVETGIAHTNQALFQVRNDTTTRVGIMALGGMVAGLVAARRRGLYNKMTAVLIGVGGTGVLCYPDQAKVLAGDAGKLAVKNARIAYHFIVGARPPIQNENGKPFERVMGMTSDIGKWGFNLFQKKNPTNVESEVITPEPAPESQQEESKPLEKSDSTDEAPAPGPAEVKENAPPSEIIKETSIDSTTESNGEVVVSAVEVEVSPAAPESPQIHEENIESAPSAPSTTTSCSDTVPSEDALIPEAETTAPIEQEIPQVEEPKNGKLETAPTPAATTVYEGDLGQGTLEDKELYTTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9H980</accession>
    <name>E9H980_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_326935</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732607">
        <property type="protein sequence ID" value="EFX71749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71749"/>
    <dbReference type="EnsemblMetazoa" id="EFX71749">
        <property type="protein sequence ID" value="EFX71749"/>
        <property type="gene ID" value="DAPPUDRAFT_326935"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326935"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2322734_0_0_1"/>
    <dbReference type="InParanoid" id="E9H980"/>
    <dbReference type="PhylomeDB" id="E9H980"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="PTHR13954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="99" mass="11434" checksum="5D501DB16CE55020" modified="2011-04-05" version="1">MVSKFFQKEAKEHILMEHENVLKLWDVRYSNDNSFLQLVLELCAGTLKDHSVGKYVGPMPENTMFFYQLTNGSHYIHSNGLVHRDLKPENLLISVTTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9U4</accession>
    <name>E9H9U4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein DpuGr22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DpuGr22</name>
        <name evidence="5" type="ORF">DAPPUDRAFT_255662</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732609">
        <property type="protein sequence ID" value="EFX71549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71549">
        <property type="protein sequence ID" value="EFX71549"/>
        <property type="gene ID" value="DAPPUDRAFT_255662"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_255662"/>
    <dbReference type="HOGENOM" id="CLU_058520_0_0_1"/>
    <dbReference type="InParanoid" id="E9H9U4"/>
    <dbReference type="OrthoDB" id="731934at2759"/>
    <dbReference type="PhylomeDB" id="E9H9U4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="PTHR21143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX71549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="388" mass="43557" checksum="B35DD741013D5245" modified="2011-04-05" version="1">MLLSIETSLWPLMVGLRIFGFHMGPSQKSGSSRYSVGLLLTGSLTVLSTVALHCTSFVYGVLRLKANGLGPNGTNLTTANLLNIGIEHLNYTWVLIAIHTTFFFVSLTSSWTELWDSLLVLEKNLKFNSTFYAKCRKSFLIGFAFLLMDCLSHLLVSMRSIYWDMGVMSPLAIVLANISRTTIISVFLLFCVMARVITLVFQGLNEQIARIDEAEQFSPFYLTGRIWNGRLEKWRRNHALACELVEMVNKCFGVVMLVTVVNVFVSFITTTFEIVRSMQEDATIPVLFVFIFVKKSILLSIIIYEPYRLQAEAGRTAVSLRKLQPSTADLLSQIKLNTVVIEVTHASPKITAMEFFDVNRRLLPTLIGSTLTYVAILCQASSTHSTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9V9</accession>
    <name>E9H9V9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DAPPUDRAFT_327119</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732609">
        <property type="protein sequence ID" value="EFX71542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71542"/>
    <dbReference type="EnsemblMetazoa" id="EFX71542">
        <property type="protein sequence ID" value="EFX71542"/>
        <property type="gene ID" value="DAPPUDRAFT_327119"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_327119"/>
    <dbReference type="eggNOG" id="KOG1052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007257_1_1_1"/>
    <dbReference type="InParanoid" id="E9H9V9"/>
    <dbReference type="OMA" id="FNYTFKL"/>
    <dbReference type="OrthoDB" id="188544at2759"/>
    <dbReference type="PhylomeDB" id="E9H9V9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008066">
        <property type="term" value="F:glutamate receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004970">
        <property type="term" value="F:ionotropic glutamate receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904315">
        <property type="term" value="F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Dong Q."/>
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                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="507" mass="57098" checksum="0BFC9FD65E7C5B6E" modified="2011-04-05" version="1">MTFPHHQLYPLRVTAVEYKALRECGILLRLPTSRGKRGGRVRLRSSGGAEIKTHLGLVNACSLTKRSELITDLILTTRVDVLAITESWLTIDHGDTDLKAMCLIGYSAIHSPRVINKSGKRRGGGLAVLFRESIKYQRLSELPKLLSFEHLDVQFSIRSQHIQLIVIYRPPDSSFPTFLDEFALLLEGMSSTRRKLIILGDFNLHIDSRCNVTGQRFLALIESFGMVQRVSGATHKRGHTLDLIITRLSDDMVSKIVVGYLISDCNVVSCKLNIQRPLLPTKKVRFRQLKSIDLDSFKADLLTLPLITNPADSLDELVQGSPHAVIKLRLSIVWSFFADDVDPVAINASTRLVPTVTSIVNGLFSTLRGGGIHVLIDLVDFRFLDYPKRLSHYFVDYFFVYEFLGFFVCDFLYIPLHVTSHELQARGSAKFPILSPCKSQSEEKTRLQLRHLAFDIAFSLEWLGSHMAKFKPRFFSSLALARARLENLATPLAFMAVDTSLQALSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HBH1</accession>
    <name>E9HBH1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_256492</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732616">
        <property type="protein sequence ID" value="EFX70841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70841">
        <property type="protein sequence ID" value="EFX70841"/>
        <property type="gene ID" value="DAPPUDRAFT_256492"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_256492"/>
    <dbReference type="HOGENOM" id="CLU_2833783_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="66" mass="7521" checksum="AB7422060682FB11" modified="2011-04-05" version="1">MIIYQKEKQAIDNKRKGAALWEITAMPKRGDMPQAVWNEGGGSPRDQKRSRTTTLFPKCSMLGIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9HBX3</accession>
    <name>E9HBX3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">inx</name>
        <name evidence="9" type="ORF">DAPPUDRAFT_60881</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell junction</location>
            <location evidence="7">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6 7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL732617">
        <property type="protein sequence ID" value="EFX70792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70792">
        <property type="protein sequence ID" value="EFX70792"/>
        <property type="gene ID" value="DAPPUDRAFT_60881"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_60881"/>
    <dbReference type="eggNOG" id="ENOG502RZVE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035763_0_1_1"/>
    <dbReference type="InParanoid" id="E9HBX3"/>
    <dbReference type="OMA" id="WHSGINL"/>
    <dbReference type="OrthoDB" id="738314at2759"/>
    <dbReference type="PhylomeDB" id="E9HBX3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="PTHR11893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 6 7" id="KW-0303">Gap junction</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241027" description="Innexin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6 7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6 7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6 7">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX70792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="435" mass="50751" checksum="6636B176FE4D1896" modified="2011-04-05" version="1">MQHRRCTIVFLLLLSLPLFTKQFAGEPIECFTPTYFTEAQSRYVNSYCWTVSTFYMDQNQPQPSQQPQPPTSNGDSLEAKRTIYENDYGNGRVKVSYYQWAPMILLAKAITFYVPFAIWKSLARRRGISLRQLMKRITRLSQISPSHPDRSNLLHEILEQIQFLVRGSNRSKQQSGTVNNKPQRTVSPIKLTMQQSQLFITFLFIKILYLLNDLLQFYLLVTFLGDDYLTHGWEIIRHLWTKRQWWSSPRFPLQTLCSVRAAQQGSLRLYQCHCVLPINLFNEKICSIWWFYIVALLPLTITSLLIWCYRNCLASVRVEFVEHYLYPNIDMSSDEEDDSLRLNCRSFTIDYLGCDGVFVLRLIEINHGSTTLRTIVQELYKRSGYLQNVTNNPESRPSTPIPTIAVAIPQVTNQNIYSFMDNYSLLTSIDTELFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCQ9</accession>
    <name>E9HCQ9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_112670</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732621">
        <property type="protein sequence ID" value="EFX70473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
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        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCR9</accession>
    <name>E9HCR9_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="1226"/>
        </location>
    </feature>
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        <location>
            <begin position="810"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX70468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1514" mass="164953" checksum="45A677ECE613A60F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDC1</accession>
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        <recommendedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_61492</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX70274">
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        <property type="gene ID" value="DAPPUDRAFT_61492"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_61492"/>
    <dbReference type="eggNOG" id="KOG0569">
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    <dbReference type="InParanoid" id="E9HDC1"/>
    <dbReference type="OMA" id="KVQWRFF"/>
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    <dbReference type="PhylomeDB" id="E9HDC1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0015749">
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        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00083">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="380"/>
            <end position="399"/>
        </location>
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            <begin position="411"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
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        <location>
            <begin position="87"/>
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        </location>
    </feature>
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        <location>
            <begin position="16"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX70274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="544" mass="60233" checksum="5BE352A774EDE58B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX70178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_257479"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_257479"/>
    <dbReference type="HOGENOM" id="CLU_2087198_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="117" mass="12796" checksum="0AD710C9DD278D2C" modified="2011-04-05" version="1">MIRCAVNQQRRSDAGRRNGDHCLPLSLQYGDESVVQERLPRSSRAIQEILMRNCIFSIVDGSHDLIEGSPLTFTLVVLDLTHSLGYLQRELSRPRGCPFGGPTPAGSSRGGDILGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9HE01</accession>
    <name>E9HE01_DAPPU</name>
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        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="3">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">EIF6</name>
        <name evidence="4" type="ORF">DAPPUDRAFT_300595</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
        <text evidence="3">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-6 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX70012">
        <property type="protein sequence ID" value="EFX70012"/>
        <property type="gene ID" value="DAPPUDRAFT_300595"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300595"/>
    <dbReference type="eggNOG" id="KOG3185">
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    </dbReference>
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    <dbReference type="InParanoid" id="E9HE01"/>
    <dbReference type="OMA" id="GEDTTGP"/>
    <dbReference type="OrthoDB" id="1157302at2759"/>
    <dbReference type="PhylomeDB" id="E9HE01"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
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    </dbReference>
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        <property type="term" value="P:maturation of 5.8S rRNA"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:maturation of LSU-rRNA"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="PTHR10784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX70012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="246" mass="26635" checksum="AC40266454EFFB83" modified="2011-04-05" version="1">MAVRVQFENNNEVGVFAKLTNAYCLVAIGGSENFYSVFESELSDTIPVIHTSVAGCRIIGRLTVANRHGLLLPNSTTDQELQHIRNSLPDSVKIQRVEERLSALGNVIACNDYVALVHPDLDKETEEVLADTLNVEVFRHTIAGSVLTGSYCAFSNQGGIVHPKTTVADQDELSSLLQVPLVAGTVNRGSDVIGAGLVVNDWSAFCGFDTTATEISVIENVFRLNEANQPSVITTDMRESLIETLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HE77</accession>
    <name>E9HE77_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_257788</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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</entry>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Basu M.K."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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            <begin position="1990"/>
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        </location>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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</entry>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="679" mass="76855" checksum="4C1F87BA3B85DCFD" modified="2011-04-05" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DAPPUDRAFT_116173"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG3544">
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Collagen"/>
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    </evidence>
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</entry>
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        </submittedName>
    </protein>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamada T."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX65478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="358" mass="39359" checksum="5010195CA32B715D" modified="2011-04-05" version="1">MVFPLFCAVLKATAYADDVSLIGTTPEQLQFILYAMLMAAKLVLRFNVRYNAAYMKTYRKLFNARKVEACSNQNIKCIVNGNLSIVTVNNHKISSDVPDGVVFTSSDDVRYKNRPSEGYIVNFQGNQPQISYFNGRSDQGSPSAAPVVLDGLVVTHGVNGGPSVEDTPLVLGELAIKYRDVRPKEPTTYATQRHSDISSSNLPQCKKDKAKFTSSTYSSASADHTDSISSNLPQCKKDKTKFTSSTFSSASTDHVQNSRLLSGSFTSPASSSSHSYDSPSYNSDPLLNGLRPLLLDKESTSQEFKSPSTGNAVTKLMESPHRKTDFSQRLPLGWRETIDPKDWQWIGQHLFASKGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9HSA2</accession>
    <name>E9HSA2_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="388" mass="45623" checksum="89B4E17527D34370" modified="2011-04-05" version="1">MQLSAAALYKTLPLDARVDWPKRLTVDVIVLVDWFGESLPGSAIFALKEILTKWDPSSTYKGVIKLLSKGYDDWLSRFPMQTTNPHATAFVKETPVEDFSPDDIEYPDFDEAMRPPTIEMSTPSQPLINRTTKPAIEIKKIEEIPIDQPVTYPVPLPRSTIPKMPSIEKETDKIITEPSPVNRVGPVPKVDRNLKINAMVKYLQDEETLVEKHLAMTVNQLEKEKEWDKIRSEREASANNEITNQLQEREKQMLEMFNKMENDNKQQELEIARLRKQVETIRTAMENKTKPDAEENQIQARINEKEVKQAVMNREVERLRELRKDKEKAREKEKEEREKDDELKRNMQRLKDDQARKNEELKKKREEENKREEEKRRLETSRGKFLKM</sequence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DAPPUDRAFT_33436"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <position position="1"/>
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    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX64439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="211" mass="24602" checksum="045D68252EB3CAA1" modified="2011-04-05" version="1" fragment="single">ERNWQRFSFILDQYQEQPHLIDSHLDGLLTKIINIIREEGLDYEVKHVAFCCLYFILKVRGFKVVARHLPHETADLEPLLHYWENQDPGVQLKWETHNGLLLWLSIVVKIPFHLQRFDTSTSEPIMERILNVCKKYLAGTTKALDMAFYVSAIYLTRPDVKDSYLPGFINWAHEVLTKDSAQFKEGVLSTLAGVFKHGQREQMMEHAHAVL</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="1">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
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    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733187">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX63168"/>
    <dbReference type="EnsemblMetazoa" id="EFX63168">
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        <property type="gene ID" value="DAPPUDRAFT_335857"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="project" value="InterPro"/>
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            <end position="195"/>
        </location>
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            <position position="195"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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    <name>E9HYW6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Focal_AT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733234">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX63065">
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        <property type="gene ID" value="DAPPUDRAFT_67424"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_67424"/>
    <dbReference type="eggNOG" id="KOG4257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133026_0_0_1"/>
    <dbReference type="InParanoid" id="E9HYW6"/>
    <dbReference type="OMA" id="VIEMSYR"/>
    <dbReference type="OrthoDB" id="1920461at2759"/>
    <dbReference type="PhylomeDB" id="E9HYW6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036137">
        <property type="entry name" value="Focal_adhe_kin_target_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005189">
        <property type="entry name" value="Focal_adhesion_kin_target_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03623">
        <property type="entry name" value="Focal_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68993">
        <property type="entry name" value="SSF68993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Focal_AT" evidence="1">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="149" mass="16793" checksum="5F39E1A926EDE989" modified="2011-04-05" version="1">MEPIPTARLDRTHDKVCDVTTSVVAVMLLFQGVQQAKIENYVDLVKKVGLELRTLLTSVDQLVPHFPPSTHREVEMADKVLSKDMAELVSALKLAERYSNTTLDNEYRKGMLSAAHILAMNAKNLLDVLDHVRIQHPHVKVYFSSSNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZJ7</accession>
    <name>E9HZJ7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_269633</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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                <person name="Basu M.K."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        </source>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="205" mass="24125" checksum="5F590A563EB2F122" modified="2011-04-05" version="1">MPSLLRKMEQEMGEKPSKIYRKVNETVPCDNAKMQLRKFGFRSNVEVSEYLDDIRQLFSQLDNKKYNDLLLEFCTSWNKEFANYFRKFIHKDVQRIGLWVIKKHGLTSATKNRAESINALLKRFVDWKESPVDTMILALEGISASFYSEILRGRYVRGNYHLHQDFTSLYDLEKDCPFLPEVRHEEEIFKSLKDAVGKATEIVIS</sequence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2J4</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="2">
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Andrews J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_121030"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_121030"/>
    <dbReference type="HOGENOM" id="CLU_1422825_0_0_1"/>
    <dbReference type="OrthoDB" id="1727271at2759"/>
    <dbReference type="PhylomeDB" id="E9I2M2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61705">
        <property type="protein sequence ID" value="EFX61705"/>
        <property type="gene ID" value="DAPPUDRAFT_272134"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_272134"/>
    <dbReference type="HOGENOM" id="CLU_2322717_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9I2S5"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="99" mass="10805" checksum="4950314597240F2F" modified="2011-04-05" version="1">MDSETDQENTGHTSSVITDDAIHPVTVLSNQVDSEVDSQIVEENTGRANTIRHVIVLSNQVDSQIDEENTGRVSSVISCCRLDAIHPVTVLSDQMPFVL</sequence>
</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_272884"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_272884"/>
    <dbReference type="HOGENOM" id="CLU_495465_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="EFX61530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="103" mass="11319" checksum="502849284D1BDC98" modified="2011-04-05" version="1">MSEESVTVAATLPTAPVRSHSTECVNDLSMDNAPMETDDLHVDRLASVHLIHRLCMTVVRRHHPSFLAVKDRISVSCHAVIQASFSFLCLRGISNPNPQVNEG</sequence>
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            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61495.1"/>
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    </dbReference>
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        <property type="protein sequence ID" value="EFX61495"/>
        <property type="gene ID" value="DAPPUDRAFT_273096"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1507071_0_0_1"/>
    <dbReference type="InParanoid" id="E9I3D6"/>
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    <dbReference type="PhylomeDB" id="E9I3D6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:DNA replication, removal of RNA primer"/>
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    </dbReference>
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        <property type="term" value="P:RNA phosphodiester bond hydrolysis, endonucleolytic"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="179" mass="20057" checksum="8950D6CA5B22F3AB" modified="2011-04-05" version="1" fragment="single">MDAKRSTPVEMLYSETGTESLSWRTKLLTRKYLVNLSHKPNNPMHKPLVTLATTTTQWKPRSTPGLIKEFVFVKSLGISLFSQQLRLPSTYKYPPPSRPPDCKTSWFPLNKEQAMACRHRTTSLFNTLDSSAPATSIRAYTDGSKSSSPETTTCAIFIPALNKEHAWTLTKGSSIFTAE</sequence>
</entry>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734741">
        <property type="protein sequence ID" value="EFX61340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX61340">
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        <property type="gene ID" value="DAPPUDRAFT_37139"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:LUBAC complex"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
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            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18091"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX61340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="131" mass="14770" checksum="CE6DEF7A8CE9AB4A" modified="2011-04-05" version="1" fragment="single">EFCSGCDRQFLMGSRCGVGPFCDKLGLHAHHPRNCLFYLRDKEPRDLQKLLTEHGVPFMTEPHDSTEGPKQCVVQLQRETSEGLVDDVCSNEVKEGQAGLCRLHYVEYLAALITKNDVDPLDIFSSDELET</sequence>
</entry>
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    <accession>E9I403</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Yamagata H."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EFX61277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="51" mass="5801" checksum="32C01F3F177399A7" modified="2011-04-05" version="1">MLLRTLAKFSVKKTNFFWTEVNPCVKEAEYAVRGVVPTLANNMQTNIKKGI</sequence>
</entry>
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    <accession>E9I6K2</accession>
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        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
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    </gene>
    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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    </evidence>
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    </evidence>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Robertson H.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    <reference evidence="2 3" key="1">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
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                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="186" mass="21442" checksum="C2EF35BC8B057569" modified="2011-04-05" version="1">MSAIVSCTSHLVKKHFGASKEFMLNRMLPFHRLDPLTVRYKLLVSIIAQKLILLNQQTREFIAPSRSCVVCVDHLHHARDNQDQHRLDQEEEKNGEAKNDDTHSNPQQRKPAEGKAHPSPATTTFKRKGTPIPRNFNLQKERAVRLSFTFEGHGDHYIKRAMQWCRGWVRTGRVSSFPSSYNSRNA</sequence>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <begin position="285"/>
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        </location>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX89381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="971" mass="107990" checksum="E79541BAC4804204" modified="2011-04-05" version="1"> </sequence>
</entry>
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    <accession>E9FTN7</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX89396.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX89396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="238" mass="26236" checksum="8FC212CB5F4226A0" modified="2011-04-05" version="1">MARTNTGRCWTFLLTSAPEVQLMVASSTPAGTPVFRFHAVRSPTDRDDDLSVFFFLASAESAASSSGAGGSSAKRSLFVLDSLTGILAVAADVNLQDRVTRNKEPDVSSMSPTDQQLCNAIRNDMCDLGITIYYSRTDMKPKPPSESFVDFPKKPFGPAAQYERPDSLKEIELQIPSCTDWCFGPNRSGSATVSTMLRVFENRPKGTDLIDLSYRSANFKQFCPDLRMSYSLHQFKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">DAPPUDRAFT_304726</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
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            <end position="48"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX88656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="153" mass="17911" checksum="9E131385C8BAD4BD" modified="2011-04-05" version="1">MAMMTCFFFIDLHVNCCRPRWWKNVPRLFARISSTFPLMLFVFISFTLHDLTFFFNTKIIIMRTSLDAHNNANPSKRHRVTVVSRPAVVCNKSRKSSVISITPKLRVFLTNNEICFLFPSSRDGFSDNRNHPLCFFSFSPIILLVSRRITTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9FX70</accession>
    <name>E9FX70_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_42520</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX88319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88319"/>
    <dbReference type="EnsemblMetazoa" id="EFX88319">
        <property type="protein sequence ID" value="EFX88319"/>
        <property type="gene ID" value="DAPPUDRAFT_42520"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_42520"/>
    <dbReference type="eggNOG" id="KOG1617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_0_2_1"/>
    <dbReference type="InParanoid" id="E9FX70"/>
    <dbReference type="OMA" id="KRFNMAS"/>
    <dbReference type="OrthoDB" id="1169813at2759"/>
    <dbReference type="PhylomeDB" id="E9FX70"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX88319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="218" mass="24077" checksum="5523AD7F7577688C" modified="2011-04-05" version="1">MSFKNFCTQNVPEKKDQTENILTVPNVLTVGRMVMCPFLGYLVIQNDYSMAFNLFVVAGITDLLDGWIARTFPSQASLAGSFLDPLADKLLLGTLFISLTYSGLIPLPLTLLIVARDALLVAAGFYIRYISLEQPRTLSRYFDPSLATAQLAPTNISKFNTAIQLLLVASSLAVPAFNLDESVLPFLWYVTGTTTVLSGLSYVFAKNTYRIITRSRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9FX86</accession>
    <name>E9FX86_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="2">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_305670</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88311"/>
    <dbReference type="EnsemblMetazoa" id="EFX88311">
        <property type="protein sequence ID" value="EFX88311"/>
        <property type="gene ID" value="DAPPUDRAFT_305670"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305670"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_3_2_1"/>
    <dbReference type="InParanoid" id="E9FX86"/>
    <dbReference type="OMA" id="LIKMYLY"/>
    <dbReference type="OrthoDB" id="693882at2759"/>
    <dbReference type="PhylomeDB" id="E9FX86"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="SSF48225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX88311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="651" mass="73702" checksum="A3A144A2CEFDC206" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9FX89</accession>
    <name>E9FX89_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_234710</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88309">
        <property type="protein sequence ID" value="EFX88309"/>
        <property type="gene ID" value="DAPPUDRAFT_234710"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_234710"/>
    <dbReference type="HOGENOM" id="CLU_2760384_0_0_1"/>
    <dbReference type="OrthoDB" id="1885897at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="70" mass="7957" checksum="4B2009E78A9301B3" modified="2011-04-05" version="1">MNKTQFYVILGVVVGLLLLLLLVFTILAITYARRRNNVPLLPLTQAPSENSYGSQERRVRGLLRTPLRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXN8</accession>
    <name>E9FXN8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_11231</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX88127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88127"/>
    <dbReference type="EnsemblMetazoa" id="EFX88127">
        <property type="protein sequence ID" value="EFX88127"/>
        <property type="gene ID" value="DAPPUDRAFT_11231"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_11231"/>
    <dbReference type="eggNOG" id="KOG3617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001853_0_0_1"/>
    <dbReference type="InParanoid" id="E9FXN8"/>
    <dbReference type="OMA" id="CESHDFA"/>
    <dbReference type="OrthoDB" id="41516at2759"/>
    <dbReference type="PhylomeDB" id="E9FXN8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF48452"/>
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    </dbReference>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX88127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="616" mass="69824" checksum="D506D1EA830F6B3D" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYN6</accession>
    <name>E9FYN6_DAPPU</name>
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        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_207386</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87737"/>
    <dbReference type="EnsemblMetazoa" id="EFX87737">
        <property type="protein sequence ID" value="EFX87737"/>
        <property type="gene ID" value="DAPPUDRAFT_207386"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_207386"/>
    <dbReference type="eggNOG" id="KOG0186">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018202_3_1_1"/>
    <dbReference type="InParanoid" id="E9FYN6"/>
    <dbReference type="OMA" id="YLNEASC"/>
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    <dbReference type="PhylomeDB" id="E9FYN6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
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        <property type="entry name" value="Proline_oxidase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="498"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
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            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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    <accession>E9FZE9</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="2">
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX87041"/>
        <property type="gene ID" value="DAPPUDRAFT_235922"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3108517_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX87041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="51" mass="5851" checksum="AC69915F326B74BE" modified="2011-04-05" version="1">MCNPGSMLRPRAPTVDSRCRQIGLVRMTSFKRFQSAITERTNPPRQGPLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZN4</accession>
    <name>E9FZN4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_236003</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87088">
        <property type="protein sequence ID" value="EFX87088"/>
        <property type="gene ID" value="DAPPUDRAFT_236003"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_236003"/>
    <dbReference type="HOGENOM" id="CLU_2624528_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9FZN4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX87088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="78" mass="9022" checksum="2A5E3A3BC667F630" modified="2011-04-05" version="1">MELNPPPWNTVDIVVHSQGVIDVLLDKHDFSMSFIDGKEKITVDQMPLFSPIPYDVKKRLMLIKVQLTWLYSTQGIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9G001</accession>
    <name>E9G001_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_307160</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87139"/>
    <dbReference type="EnsemblMetazoa" id="EFX87139">
        <property type="protein sequence ID" value="EFX87139"/>
        <property type="gene ID" value="DAPPUDRAFT_307160"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307160"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_13_1_1"/>
    <dbReference type="InParanoid" id="E9G001"/>
    <dbReference type="OMA" id="TESDHAC"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="PhylomeDB" id="E9G001"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX87139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="245" mass="27101" checksum="B72DA293DBC85BA6" modified="2011-04-05" version="1">MVASKESRENVYPFMVALVTYNADLTESDHACGASLITSTKLLTAAHCITKLKTNIYQPNNYYAHLGMHFRNSTYTDAKAIRKIVGYKIHENYDPSTKANDMAILTLESPVEFTETISPVCLPQKCMNVKFVGRSVMAMGWGDTKENGNHSDFLRSASFDVISKAKCSRHYDDLADHMFCTYKEGQDTCQGDSGGPLVTDQGPSDNCKFVQVGVVSYGDGCAKKGVPGVYMKVTSFVPWIQRNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9G0V0</accession>
    <name>E9G0V0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_44029</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenomatous polyposis coli (APC) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX86971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86971"/>
    <dbReference type="EnsemblMetazoa" id="EFX86971">
        <property type="protein sequence ID" value="EFX86971"/>
        <property type="gene ID" value="DAPPUDRAFT_44029"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_44029"/>
    <dbReference type="eggNOG" id="KOG2122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089527_0_0_1"/>
    <dbReference type="InParanoid" id="E9G0V0"/>
    <dbReference type="OMA" id="HIATRDD"/>
    <dbReference type="OrthoDB" id="20299at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045295">
        <property type="term" value="F:gamma-catenin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016043">
        <property type="term" value="P:cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026818">
        <property type="entry name" value="Apc_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12607">
        <property type="entry name" value="PTHR12607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX86971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="214" mass="23438" checksum="92360DAE6A506EFF" modified="2011-04-05" version="1" fragment="single">MSHLGALQGLSELLHLDQLAHGSLCDDAQCTTLRRYASMTLTNLTFGHGPNKTLLCSTRPLLAVLSHQLASPNDDLRQVTASVLRNLSWRADSASKDALQQTNVVQSLITMSMETHRESTLKSMLSALWNLSSHSSCNKATICATPGSLEFLVRTLTYKSESKTLSIVESGGGIVRNISSHIATRDDYRATLRRHGCFQILLHHLRSPSLTVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9G182</accession>
    <name>E9G182_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reelin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_312997</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86626">
        <property type="protein sequence ID" value="EFX86626"/>
        <property type="gene ID" value="DAPPUDRAFT_312997"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312997"/>
    <dbReference type="HOGENOM" id="CLU_2135988_0_0_1"/>
    <dbReference type="OrthoDB" id="1223313at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reelin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX86626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="113" mass="12445" checksum="BD67793C5EF6867F" modified="2011-04-05" version="1">MAFDDYGEAIGTFSVDEYAGYSMSCPYGRNNAVTHIMNDDKSFVQLNWMAPPYFTGPVHFRATFVKDVANYWVKVNSSVVNVVPFVMPSSGVNFASTSPLMALPLLALIVGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3K6</accession>
    <name>E9G3K6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_313599</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85791"/>
    <dbReference type="EnsemblMetazoa" id="EFX85791">
        <property type="protein sequence ID" value="EFX85791"/>
        <property type="gene ID" value="DAPPUDRAFT_313599"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_313599"/>
    <dbReference type="eggNOG" id="KOG3607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_763462_0_0_1"/>
    <dbReference type="InParanoid" id="E9G3K6"/>
    <dbReference type="OrthoDB" id="1507734at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX85791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="363" mass="37054" checksum="9631DAF88C582520" modified="2011-04-05" version="1">MDGISSASHSHVNSPNSTPAHHGISNHIMQASASEDETLQSGEDEGTAFLDGMPQSNNLSGSGMNKQPEKGILKKSGGGVYGSVGGGGGISSSQQQLGGGGGGGGGGHGGPSLTLPLGRMNSGSSMMMNKEKWSEESQSDNQEVMSVLLSPDGGSSRISDRLAASSLSDVERTLKSLNGYHEDILQALRSAAASQRSASTASLSDELRKSFAESYADYFPPPDYLSMRSLNNHDKHGGVGGRGGVMGPGSSVSSTSERLPGLASPLPGGGSLGVGAHGGGDSGDEGDLVPPCGPIRIRNLEDLIRQLERHSARHTSPNGSEDIRMSETEADRHYRLMEAAAGGGVPGLGASDSQAGSVLFNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3M2</accession>
    <name>E9G3M2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_237320</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85960">
        <property type="protein sequence ID" value="EFX85960"/>
        <property type="gene ID" value="DAPPUDRAFT_237320"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_237320"/>
    <dbReference type="HOGENOM" id="CLU_2348804_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX85960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="97" mass="10430" checksum="4E4B1FAE9399CF93" modified="2011-04-05" version="1">MADFVADNSHHKPAQPSEPVELMDELSEDVLPPRSDIEGTLASEPSSKTLEMSEDSQVQGNDSKSSSGMVGESKSQELASVVENAGKTTEKEGNCYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3Z0</accession>
    <name>E9G3Z0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldo_ket_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Pritham E.J."/>
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                <person name="Shapiro H."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="217" mass="24357" checksum="7DFD7907D60011F7" modified="2011-04-05" version="1" fragment="single">MDDEFPDPDEEYEMRYAEEFELMNELVFPLDFEENSAPVLPKGNDKKVKKSLNFHDGNGSRSNSSLSGHAAPDIGSRSNSSMSGHAAPLSDEAGRKRMQDEVFGSLSDDEELCGKGSNPSKKSRNDDILFDGPVTHATPEYYEEPRAFRAPRPKRYVFRLVPAEPHQCVTTHTGQKLFIRLKTEESLKQTDIDLNSKSVGNLLKVSVATLKLQMYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9G899</accession>
    <name>E9G899_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_209641</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX83941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83941"/>
    <dbReference type="EnsemblMetazoa" id="EFX83941">
        <property type="protein sequence ID" value="EFX83941"/>
        <property type="gene ID" value="DAPPUDRAFT_209641"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_209641"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_22_0_1"/>
    <dbReference type="InParanoid" id="E9G899"/>
    <dbReference type="OMA" id="HEHRALT"/>
    <dbReference type="OrthoDB" id="702827at2759"/>
    <dbReference type="PhylomeDB" id="E9G899"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX83941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="458" mass="51177" checksum="E57AEF0CB16D3F7B" modified="2011-04-05" version="1">MSKKDPFFKTMQKLAKTYGPVTGFYLGPTQPFISVVGAQAVREALQNNDLSGRPSGAILLSRTFGERLGLTFVEGDVWQEQRRFTLRHLRDLGFGKTSIEDQMMGEITDLISEINATAKSNRDHVVDFKSIFSVSVINILWAIVGGKRFQRDDPKFKKLLDNIDQFLQSGDVLQANLPVPAILVRLFPSLPGRLGINTQLFVPIQKFIEETIDEHISTRLKGDAARDYIDVYLDEMERQLKTNESTTFSKKQLISSIQDLFGAGFHTSSSSIGFAVLYMIHYPTIQQKMRDELDDICGDSLPSLAHRLQLPYTEAVLMEVMRIATIAPAGVPHCAMKETQLQGFTIPKGSILAINLDSASNDATAWKDPENFRPERHLDKNGKVIKNENLIPFGLGRRVCLGEPLARNTMFLFVASLVKTFAFKSVPKEPLPTLEPNAAILLSPKPFFATAIPRVYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9G994</accession>
    <name>E9G994_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_301394</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84125">
        <property type="protein sequence ID" value="EFX84125"/>
        <property type="gene ID" value="DAPPUDRAFT_301394"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301394"/>
    <dbReference type="eggNOG" id="ENOG502S4KI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075165_4_0_1"/>
    <dbReference type="InParanoid" id="E9G994"/>
    <dbReference type="OrthoDB" id="1583175at2759"/>
    <dbReference type="PhylomeDB" id="E9G994"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012181009" evidence="3">
        <location>
            <begin position="16"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX84125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="183" mass="20066" checksum="FB3EAC9E3FE792B5" modified="2011-04-05" version="1">MKFLILAALFAVAAADSYRSAEYAPKYEAPAYKSTYEAKYETPQPYDFSWAVNDYYNDYSHSESSDGKVTTGSYRVVLPDGRTQIVTYKADSYGYVADVKYTGEAKYPEYVANNYKATTYSAPAYKPTAPTYSAPAYTAPTYTAPAKNGPTYTVTAPTYSAPAPAPSYTATPVYKAPAVQPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9R6</accession>
    <name>E9G9R6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_239647</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83837">
        <property type="protein sequence ID" value="EFX83837"/>
        <property type="gene ID" value="DAPPUDRAFT_239647"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_239647"/>
    <dbReference type="HOGENOM" id="CLU_2173508_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX83837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="110" mass="11533" checksum="7C87427454EC5A5F" modified="2011-04-05" version="1">MVFCTKQLEVIVDYSLHPLITIMDPRMDLEQGLKMRVLLLQNGATNQPANVDVYPVANAADVDVNLANLVDVPVVKPQARAAVRVAVTAANRAAGAGANVDGDPAANAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GB36</accession>
    <name>E9GB36_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_301880</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83437">
        <property type="protein sequence ID" value="EFX83437"/>
        <property type="gene ID" value="DAPPUDRAFT_301880"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301880"/>
    <dbReference type="HOGENOM" id="CLU_842672_0_0_1"/>
    <dbReference type="OrthoDB" id="1880095at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240786" evidence="2">
        <location>
            <begin position="24"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX83437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="330" mass="36184" checksum="86B8A9D1806FD8E4" modified="2011-04-05" version="1">MSLSSRIWISALFLVGTIWWVNGAAVPSSSGNFQPPPQRDVPDSQRNASAPVPADFKTFKPMEPTRPNSPNLPPPPQPFGINSNMQMPPQTPPQGFFMTPPPGFRPGMVMMPQPTMLPPVMNAPNQQQGQTQQPKLTNSTTMQFAPPLSSNATRLNNNTRRETEQSPSTPAATTTSTTTTRKPFQELPLGADKQESDGSKLKQTSSSAAPQSLPVNPFNPMMQPLNPAMQPLNPMMQPFPMMNQPPLFIDPMGRLMMLVPFNPQLLPRDPNQQQALPQGPPIPIQVPPFNPQMQFQFGQPQLRPVMADLNKQTPPPRMGDASSKNATSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBU2</accession>
    <name>E9GBU2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_100970</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732538">
        <property type="protein sequence ID" value="EFX83021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83021">
        <property type="protein sequence ID" value="EFX83021"/>
        <property type="gene ID" value="DAPPUDRAFT_100970"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_100970"/>
    <dbReference type="HOGENOM" id="CLU_121118_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GBU2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="218" mass="24892" checksum="A56A5781BB3DB477" modified="2011-04-05" version="1">MADLCFLFQCLSLSDSEKRKRTCEYEDEDIRHRRPQRIRLVKTSSELNVVGLRNVGEKIRLERSNKLPKMDEGVSPLLKGNGMEVDEDVEEIGRNLPRDKSNNRQRRIATNPEPNQHLSVRNTNRFKTLPTGKIGKGHQTRQPDRGNRLKSLLVVNLSDRGRIVELTGIGSKPNVTAGEGGDLRSLLDLKRKEKVEGVQQDLRSVLDSRRKITPVRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9GCT1</accession>
    <name>E9GCT1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polo kinase</fullName>
            <ecNumber evidence="3">2.7.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_302355</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Basu M.K."/>
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                <person name="Gerlach D."/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81574">
        <property type="protein sequence ID" value="EFX81574"/>
        <property type="gene ID" value="DAPPUDRAFT_102311"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_102311"/>
    <dbReference type="HOGENOM" id="CLU_1361660_0_0_1"/>
    <dbReference type="OrthoDB" id="1888185at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX81574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="201" mass="23047" checksum="E5D6E253D3BB0C08" modified="2011-04-05" version="1">MLGFFPPYTRLLPFTLPNFYLQITRTLKERNCANVLEDLTKKGNEFQIAGPAYEKEVEPYFFDFVDEPSDAVDGRTKRVAVVENVVPLAFSIDDVLGNDDFHETMDDGVENDDNHSIHSSIHISSESDVNFLEEVDVDSEMFLDFDFQFCEAPDFDEDLVDDVDDWDVHSDIDRNFNAIDRQNFFKKTPLSLGLDILLGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9GG54</accession>
    <name>E9GG54_DAPPU</name>
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        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL732543">
        <property type="protein sequence ID" value="EFX81554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81554"/>
    <dbReference type="EnsemblMetazoa" id="EFX81554">
        <property type="protein sequence ID" value="EFX81554"/>
        <property type="gene ID" value="DAPPUDRAFT_317504"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_317504"/>
    <dbReference type="eggNOG" id="KOG0161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1355875_0_0_1"/>
    <dbReference type="InParanoid" id="E9GG54"/>
    <dbReference type="OrthoDB" id="1174178at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="171"/>
        </location>
    </feature>
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        <location>
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            <end position="42"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX81554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="202" mass="22235" checksum="BF23280738D63C97" modified="2011-04-05" version="1">MLRFEKSTSRLQSELDVLIIDLEKANSTAREMQKRSKQLELINIEFKSKLDKIELTVLYDASQRDIIDGSLLDIAECKKIACCENNPPRLTLKSVCCMFGLAWGQARCATQSSSSAPSATPVDGKTCTDINECDLNPGICKGGGLCVNTDGSFKCTCHPVLTLYETATRCIDQRQELCYLNYHHGICTKKLDTFLGALPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GG74</accession>
    <name>E9GG74_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="4">
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        <name type="common">Water flea</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732543">
        <property type="protein sequence ID" value="EFX81542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81542">
        <property type="protein sequence ID" value="EFX81542"/>
        <property type="gene ID" value="DAPPUDRAFT_102352"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_102352"/>
    <dbReference type="HOGENOM" id="CLU_608685_0_0_1"/>
    <dbReference type="OrthoDB" id="1719718at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5003240974" evidence="2">
        <location>
            <begin position="30"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX81542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="450" mass="49705" checksum="81CCFC0D0EC158E0" modified="2011-04-05" version="1">MSSSSSNQTPAVVLICIGLALLLLSGASSFHLNDQNVSSEVIVAGEDGDVESCSSGDWAVQIPDLNFQIPGLLLKTGGNANRKPASLALVEDSKALQTWLLQITQQVASALKLSNTSATQLQLLVANVENQFQEVNRALNSSELIVELIAPPLTNITESTKAIAQLFYLMTSQFEELFNLTRAVKNSAVKIRDRLERAHLGVIKRKASRINSRRKLKLAIQSLRRTIADLTRRLQRDRVELKTTTQEWQALKSGINFTQDGEWANVKARLERAKWRWNCSRQALNKTQEKLHKWSQLDEELAVAIEESRQESAEIHDEMVLLLNGTRNSSSSSVAQLERNRNLTTDFAHYYSDAGGFFLGIGSRISNILAGIVLSQRIGAGEALATLRSHLKKVKCDLDRNGRFIILTDAGKSPKKDVNDNKRTNIVGFLLGAAAATKENCDGDFPSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9GHR1</accession>
    <name>E9GHR1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_224383</name>
    </gene>
    <organism evidence="6">
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        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
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                <person name="Rechtsteiner A."/>
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                <person name="Salamov A."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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    <sequence length="723" mass="81488" checksum="C671610C98BA1EE8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJM6</accession>
    <name>E9GJM6_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_103606</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732548">
        <property type="protein sequence ID" value="EFX80289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80289">
        <property type="protein sequence ID" value="EFX80289"/>
        <property type="gene ID" value="DAPPUDRAFT_103606"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_103606"/>
    <dbReference type="HOGENOM" id="CLU_2186562_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX80289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="109" mass="12579" checksum="599D42BD2B27C7CA" modified="2011-04-05" version="1">MTNKRKEKVFVRREVGSDLASQDKLFEGTPVDLDTDANIILMILSHKPVLFRVSEEVADSLNDLDGDYDQDDWNDWDLYLEDLDEGLSFIARQQLFRKRIATRTSIGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJN7</accession>
    <name>E9GJN7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="6">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_304174</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="GL732548">
        <property type="protein sequence ID" value="EFX80145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80145"/>
    <dbReference type="EnsemblMetazoa" id="EFX80145">
        <property type="protein sequence ID" value="EFX80145"/>
        <property type="gene ID" value="DAPPUDRAFT_304174"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304174"/>
    <dbReference type="eggNOG" id="KOG2335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_4_2_1"/>
    <dbReference type="InParanoid" id="E9GJN7"/>
    <dbReference type="OMA" id="LIYPYVD"/>
    <dbReference type="OrthoDB" id="1345916at2759"/>
    <dbReference type="PhylomeDB" id="E9GJN7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="8">
        <location>
            <begin position="15"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX80145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="303" mass="34098" checksum="C78E146C378C13EE" modified="2011-04-05" version="1">MVLELFENKKLVKICAPMVRYSKLPFRLLVRKYGCDLAFTPMIISDSFIQAPKARDIEFTTCDADQPLIVQFAAHNSTDFATAAELVASTCNGVDLNCGCPQKWAMQQGYGACLINKPELLRDVVLQTRNRIPSNDFTVSIKIRIHPEIRKTVELCQQVEAAGLSFLTVHGRTKDQRSDPVNLEGVKLIKESVRVPVIANGDICSLQDAEHVQQITNVNGVMSARGILENPAMFAGFSETPIECIKDWMKLSLETGISFTHFHHHLIYMCEKNMSRVDRRYFNALSSTTAVIDYMENYLSLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKE0</accession>
    <name>E9GKE0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_103813</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL732549">
        <property type="protein sequence ID" value="EFX80082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80082">
        <property type="protein sequence ID" value="EFX80082"/>
        <property type="gene ID" value="DAPPUDRAFT_103813"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_103813"/>
    <dbReference type="eggNOG" id="KOG4585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1715101_0_0_1"/>
    <dbReference type="InParanoid" id="E9GKE0"/>
    <dbReference type="OMA" id="IAHDHIN"/>
    <dbReference type="OrthoDB" id="698280at2759"/>
    <dbReference type="PhylomeDB" id="E9GKE0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="67"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX80082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="153" mass="16890" checksum="AA354CF095BEBD1D" modified="2011-04-05" version="1">MTKAKRRTTPFNQVLIALQFYGTGTFQTVVGNVLKYSQATVCRSIHDVSRAFFMIAHDHINFPPNLLQGVCDANGHFLSVNETKPGSVHDSTMFKTSALGLQCVQGEFGTGFLFGDSGYVCTPYLVTPFNINSNDEENFLKNKTPRSYSPSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GM89</accession>
    <name>E9GM89_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_319602</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732552">
        <property type="protein sequence ID" value="EFX79322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79322">
        <property type="protein sequence ID" value="EFX79322"/>
        <property type="gene ID" value="DAPPUDRAFT_319602"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_319602"/>
    <dbReference type="HOGENOM" id="CLU_2796555_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX79322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="68" mass="7767" checksum="CA7B8458649F87F1" modified="2011-04-05" version="1">MNLNVSSTILSFAHFKVNPKSVYASGNQDRMSWIAKLSFDQSNGWNGVDQMIRSNESCRAAKHLRRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GNR9</accession>
    <name>E9GNR9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_320073</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732555">
        <property type="protein sequence ID" value="EFX78807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78807">
        <property type="protein sequence ID" value="EFX78807"/>
        <property type="gene ID" value="DAPPUDRAFT_320073"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_320073"/>
    <dbReference type="HOGENOM" id="CLU_1898334_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GNR9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX78807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="134" mass="15215" checksum="8920B98E7C2DF07B" modified="2011-04-05" version="1">MKAGIRTCSCVKQPHTDSDSSSYRICLIGNMERKGCDLRSEEQKARVKKYINDSRRKGMKSFGLFASGANNSGDGCKQKSSELVAQSRNKRKRDESFYLWPDIHDQPADSFHFEPDFNQTVPNSCKVLLKVFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GP23</accession>
    <name>E9GP23_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_245780</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732556">
        <property type="protein sequence ID" value="EFX78569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78569">
        <property type="protein sequence ID" value="EFX78569"/>
        <property type="gene ID" value="DAPPUDRAFT_245780"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_245780"/>
    <dbReference type="HOGENOM" id="CLU_144559_0_0_1"/>
    <dbReference type="InParanoid" id="E9GP23"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="PhylomeDB" id="E9GP23"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX78569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="127" mass="14746" checksum="EEE6E2FF1BC84BB6" modified="2011-04-05" version="1">MHSDLISDHFAVHTLVKVHKLVRLQKKVTEIRRLKSIDREAFVSDLLASSIFTDPENDIASLLAQYNTDVRAVLDKHAPLITKRLTVRPDNPCDCEEIRTCRRSLRRWERKYCARVLPSTENALLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPV1</accession>
    <name>E9GPV1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_53387</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732557">
        <property type="protein sequence ID" value="EFX78521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78521"/>
    <dbReference type="EnsemblMetazoa" id="EFX78521">
        <property type="protein sequence ID" value="EFX78521"/>
        <property type="gene ID" value="DAPPUDRAFT_53387"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_53387"/>
    <dbReference type="eggNOG" id="KOG3707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010656_0_0_1"/>
    <dbReference type="InParanoid" id="E9GPV1"/>
    <dbReference type="OMA" id="PEHGPAN"/>
    <dbReference type="OrthoDB" id="164905at2759"/>
    <dbReference type="PhylomeDB" id="E9GPV1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="313"/>
        </location>
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        <location>
            <begin position="368"/>
            <end position="789"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX78521.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="796" mass="90080" checksum="B5ECD9EDBA010BD7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9GSG8</accession>
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        <submittedName>
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        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX77579.1"/>
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        <property type="gene ID" value="DAPPUDRAFT_106003"/>
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            <begin position="1"/>
            <end position="31"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX77579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="396" mass="46030" checksum="692BA28A65494349" modified="2011-04-05" version="1">MGSKKKAEEEVTSESGEHCNPHKKKRIDVAKPNMANSKVKPRADVRRSGNFLLSKLKRFVGFPVLFPETLLYHIIDVLVVKYPNNWIMLKTGKTKNPDCLIPPEDIEPEMFIEVLELFGAAFVFQGKPNFRKLGWICWYEATVLRDKYRITKISLPQSQWETLLFGNVKVHKDARNDQIKIKDYTIKSKADKLEEISQLILILIKLLVSMPKSEAEREKLKYHLKSYTINFENKTLKKKQSTLLLRASEDYRGFEDDFDFIMLLLETGGDPNAVDQNGRSPLHVLASREIFFHPFWSFDYQAHAARFTTIVQTFFDGEFHKDQTDLRGNAALDCIKYFPQQYPNDKLRKLMDRYLQGVLPLSCIAAKVVRKHNLPWEHLPVALQSMVLKHSSFQYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="576"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="805" mass="92815" checksum="45E7C0184CDD4729" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTJ3</accession>
    <name>E9GTJ3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kelch-like protein diablo</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_305899</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PhylomeDB" id="E9GTJ3"/>
    <dbReference type="UniPathway" id="UPA00143"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0003779">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BACK"/>
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    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
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    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030603">
        <property type="entry name" value="KLHL18_BTB/POZ"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="37"/>
            <end position="104"/>
        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013699"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX77204.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="569" mass="62929" checksum="8CB394C4DED41AC9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="299"/>
            <end position="648"/>
        </location>
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        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="720" mass="81258" checksum="D0A88E946FE291BD" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9GU97</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_225916</name>
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    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Lysosome membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
            <orientation evidence="8">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GLMP family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_225916"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QSBM">
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    <dbReference type="OMA" id="TLHYLWD"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029382">
        <property type="entry name" value="NCU-G1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31981">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NCU-G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237453" evidence="10">
        <location>
            <begin position="23"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="413" mass="46538" checksum="07B709829DFF17F3" modified="2011-04-05" version="1">MTNLVLVFAAFNLLPLFVLVSSADYNTFLDVEQKNYDRNVTTTINPKCPTNECVNFTLVHVQQEGIADVLHHIWTMENVPTFFYARTELNTEMLIDWEKMLSGNYSQAISFNKEPQYFAAVLIFKFFMYNDLNDTGVIPETDNFDIVSYSTKKMSWELKSSNCSGNISASVAFRLRSYDGVELDSSSNIEITLTAYGTRGRSPILPHLAFTENSTQVDFVFDHVETKESFTNARLAMELAAVVSEPDSRFTLNVSQSLDDEYTPGVFKLMEIHSALNQHWIQWRPVCYTSTQRDIGDSTGLYQTDIRNVSDDNILDNTLLEWLSLDLDTRFLLMKGFNVSFGVEGDGFYRASNYTAWTLVTGHGRPVGDQFSLMVILVMAIGLGLPAIVLILGGAAIALRNHRNSKDDLLLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GXQ4</accession>
    <name>E9GXQ4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_323029</name>
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    <organism evidence="2">
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        <name type="common">Water flea</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX75774.1"/>
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        <property type="protein sequence ID" value="EFX75774"/>
        <property type="gene ID" value="DAPPUDRAFT_323029"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1929699_0_0_1"/>
    <dbReference type="OrthoDB" id="19805at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:centrosome-templated microtubule nucleation"/>
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    </dbReference>
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        <property type="term" value="P:mitotic spindle assembly"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Spd-2/CEP192"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="131" mass="14573" checksum="961D82067E35A7F0" modified="2011-04-05" version="1">MKLFKYGGSSHIRRLVDSTAEPLVPKPKGSVWNCQLVLKNQGNLAGYVSIQPLQENGKVLGPYHCMVMPQCCSVGVGDIKNIKIFIYPSEDGEVDVTFFKLRLVWGDEPLRARWIRCIADGAPVTPNTKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZ85</accession>
    <name>E9GZ85_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_108126</name>
        <name evidence="1" type="ORF">DAPPUDRAFT_119143</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX63518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX75200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX63518"/>
        <property type="gene ID" value="DAPPUDRAFT_119143"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75200">
        <property type="protein sequence ID" value="EFX75200"/>
        <property type="gene ID" value="DAPPUDRAFT_108126"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1090944_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="255" mass="27796" checksum="45CD0762A8FEB6EC" modified="2011-04-05" version="1">MDQSLTDAYPLKTYFVAEFRKTVSSFFATVWNATSCKYETAILAKDVLVALVAIADGDPTYGLRPPAAAFLHAAVNGNCCLIVASTGAHPLSAADWRLNDINHANAAPPRRHTVNLNKVPTHSQSAAKGNRFSYFNGCLNERGSKTFRSHRNGHNPRTVGCGQVIENCFAIKCGGCGKWGHGKYVGLKRSLAPQLDAHSWQWNCNTCLPIVKADIFMKDGNLQSAVDAVLATNNATRCKEIIQMYRRDAGGNTQH</sequence>
</entry>
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    <accession>E9GZY9</accession>
    <name>E9GZY9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_56564</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX74904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_004416_2_3_1"/>
    <dbReference type="InParanoid" id="E9GZY9"/>
    <dbReference type="OrthoDB" id="1897241at2759"/>
    <dbReference type="PhylomeDB" id="E9GZY9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX74904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="79" mass="9276" checksum="5E4EBF2D0C586879" modified="2011-04-05" version="1" fragment="single">GHTSFHGCERCNVVGRTKMKRRVFKSLNARLRTDASFRAERDKPHHKERTPLLNLGIDMVKCFPLDYMHLVCLGTFKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0B6</accession>
    <name>E9H0B6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ferritin</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FER3C</name>
        <name evidence="5" type="ORF">DAPPUDRAFT_188714</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="GL732580">
        <property type="protein sequence ID" value="EFX74776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74776"/>
    <dbReference type="EnsemblMetazoa" id="EFX74776">
        <property type="protein sequence ID" value="EFX74776"/>
        <property type="gene ID" value="DAPPUDRAFT_188714"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_188714"/>
    <dbReference type="eggNOG" id="KOG2332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065681_4_0_1"/>
    <dbReference type="InParanoid" id="E9H0B6"/>
    <dbReference type="OMA" id="ANNRATM"/>
    <dbReference type="OrthoDB" id="1249457at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006880">
        <property type="term" value="P:intracellular sequestering of iron ion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2 3" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="4">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX74776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="170" mass="19567" checksum="9FFE1BD178B70444" modified="2011-04-05" version="1">MVGKGRHNFHEESEASINKQINIELNAHYQYLALAAYYDRDDVALKGFAKFYKESADEENEHAQMLMKYQNIRGGRVVLTSINRPAQQEWTSPLVAMEFALNLEKQVNQSLLDLHKVAGIHSDPHLSNYLEEHFLEEQVQSINKLAKHHTNLLRVGDGLGIFMYDKELQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2S3</accession>
    <name>E9H2S3_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_109355</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732587">
        <property type="protein sequence ID" value="EFX73960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73960">
        <property type="protein sequence ID" value="EFX73960"/>
        <property type="gene ID" value="DAPPUDRAFT_109355"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_109355"/>
    <dbReference type="HOGENOM" id="CLU_654287_0_0_1"/>
    <dbReference type="InParanoid" id="E9H2S3"/>
    <dbReference type="OrthoDB" id="1358833at2759"/>
    <dbReference type="PhylomeDB" id="E9H2S3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX73960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="420" mass="47130" checksum="08C15ADCC3707129" modified="2011-04-05" version="1">MSLLESDQGMLLNVRDIPGLRVHGTISCICGDTKRIHELFGFSGKDIDGECLMSLSEKQIDALKLSIGHAAKLQKLVNSFNIENVNAQPPNPSGSQKPGDMNRNDLQDASVPLVEKNQNKLIVTSGQEKVPFEIFSILKDSAEGRKIINSYSERNEASLGLDERRLLVRICVSHMVMLTGKEDLYPSVALKEELAKAIVEAFPCLAIPVDWLKTHIPSLGINNETIKQHTESTYRYRQSQITAGNWTTSQIIAEYPRFRDYPLLVFYDFLTAYTKAESFEENFLGKFAPLIMSAAEKGNIAIPDTDDECLKLLILLLKLVPNLQRVKAMSKDVIIERVICFIKANDDILEVNKEHKPYLILSPFICCVGSIQHPASFSVVSEREVIHAGQTSIEAFKTLYASFHIFRIPYPSLFSTFSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9H4M2</accession>
    <name>E9H4M2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_325407</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX73167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX73167"/>
        <property type="gene ID" value="DAPPUDRAFT_325407"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_325407"/>
    <dbReference type="HOGENOM" id="CLU_1919177_0_0_1"/>
    <dbReference type="OrthoDB" id="266752at2759"/>
    <dbReference type="PhylomeDB" id="E9H4M2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX73167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="132" mass="15090" checksum="62B3A4D3D51E306A" modified="2011-04-05" version="1">MTTHAAPSCYTEAHKCYTEAPAGYSTKTVECYTEAAKYFSAPIYASTTETAKYYAVPPYNTEAALSCYLEQKYYTDAPVYYTTTYATPSFNTAAPNNSPDYVITYLRYSDLYSEFLKYFYGCVERLLKYKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9H4X9</accession>
    <name>E9H4X9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Protein N-terminal glutamine amidohydrolase</fullName>
            <ecNumber evidence="5 8">3.5.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein NH2-terminal glutamine deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_129384</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 8">Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.</text>
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        <reaction evidence="1 8">
            <text>H2O + N-terminal L-glutaminyl-[protein] = N-terminal L-glutamyl-[protein] + NH4(+)</text>
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        </reaction>
    </comment>
    <comment type="subunit">
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        <text evidence="3 8">Belongs to the NTAQ1 family.</text>
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        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
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        <source>
            <dbReference type="RuleBase" id="RU367082"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09764"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX73220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="190" mass="22155" checksum="E1BE34F075780659" modified="2011-04-05" version="1">MSISINSEDCVYTSCYCEENVWHVCKYVKENHPGLLDKCVAVFISNEKQTIPLWSQKQSTDEKGLVIWDYHVIFIYLAKENYFDVYDLDTTLPFPCSFEEYKTKALGLDHDLQTKFQRYFRVIPAEQYLATFSSDRSHMIKDGKWLKPPPNYPPILTATSANNLNDFISMSSREVPGQILNYRDFVSKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5M6</accession>
    <name>E9H5M6_DAPPU</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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            <end position="19"/>
        </location>
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        <location>
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            <end position="441"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
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    <sequence length="749" mass="77833" checksum="B7E66FFBD3B25921" modified="2011-04-05" version="1"> </sequence>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pitluck S."/>
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                <person name="Tsuchiya D."/>
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        </citation>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="84" mass="9916" checksum="BBDCA79E47352C35" modified="2011-04-05" version="1">MKESQEISDFHSSICFPLLREFLKRPNGANKFSSSWQTCRLNGPVSMSTLLMKVNLLWPDLRCRGVVFMDLCWWWYHSTMPSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6M7</accession>
    <name>E9H6M7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Wang M."/>
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                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Andrews J."/>
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                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732598">
        <property type="protein sequence ID" value="EFX72609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72609">
        <property type="protein sequence ID" value="EFX72609"/>
        <property type="gene ID" value="DAPPUDRAFT_326071"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326071"/>
    <dbReference type="HOGENOM" id="CLU_2335755_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX72609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="98" mass="10729" checksum="49CDD44E2E899573" modified="2011-04-05" version="1">MSTTIPEDQQAPAKAGECDESFFEVTAPQQEKSLDDYDCRSSFPAEILPSLGCQFLTTPSSATDFKATSAFVSKCNKQNLYRSLCVFILNDAMNTTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9H788</accession>
    <name>E9H788_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Palmitoyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_308301</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="2"/>
    <dbReference type="EMBL" id="GL732600">
        <property type="protein sequence ID" value="EFX72337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72337"/>
    <dbReference type="EnsemblMetazoa" id="EFX72337">
        <property type="protein sequence ID" value="EFX72337"/>
        <property type="gene ID" value="DAPPUDRAFT_308301"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_308301"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027721_5_1_1"/>
    <dbReference type="InParanoid" id="E9H788"/>
    <dbReference type="OMA" id="RMHIAWL"/>
    <dbReference type="OrthoDB" id="863846at2759"/>
    <dbReference type="PhylomeDB" id="E9H788"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018230">
        <property type="term" value="P:peptidyl-L-cysteine S-palmitoylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="3">
        <location>
            <begin position="95"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX72337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="290" mass="33698" checksum="F5F4019D917DB3C3" modified="2011-04-05" version="1">MLPFRDRVIPKIVSELVALGFVLFIIPAIYIFELAVVLPAVYDGKKEFDTFWLYFHSACGTFVMFNVVGNLIGVILVDTSAKHIIVDTSKADASNGWHLCSVCETISPPRSWHCSQCNTCILKREHHCGFTGCCVGYNNFRFFYLFLANLFFATIYATYFNHYYIWSQVIAFEWSHIIRIVMPLTILFFGIDTSMTQLYFFYYSITMIGCCFSGVLLYQQSYLAFFNQTSWERNKGTNEHDCGVMHNIRDALGHRWYLIWLCPFLQSPLPHEGIQWMTRKQISLEGEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9H871</accession>
    <name>E9H871_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helitron_like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_326588</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732603">
        <property type="protein sequence ID" value="EFX72080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72080">
        <property type="protein sequence ID" value="EFX72080"/>
        <property type="gene ID" value="DAPPUDRAFT_326588"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326588"/>
    <dbReference type="HOGENOM" id="CLU_1305999_0_0_1"/>
    <dbReference type="InParanoid" id="E9H871"/>
    <dbReference type="OrthoDB" id="999269at2759"/>
    <dbReference type="PhylomeDB" id="E9H871"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron_like_N" evidence="1">
        <location>
            <begin position="18"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX72080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="211" mass="24324" checksum="7585440FBBD81B7B" modified="2011-04-05" version="1">MNQFTGSMARESQFYFFLSNQRRRHEQPSLSLSRVKNTPKAFEKFENFVNNKDFHQATERAVKNPLGKDAQHILKSTAPYIQMSGKHVAFSPMERNDAMTSLCAITQRYGTPSVFLTVSPDDTHHPLTLRIAFPSTSNVKFPAKPEKFIEALINEDEEYDQVSISQLAIHKLVTDSPHASATVFKLIMEIYSVNYSKYHYRRQQKNYAIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9B5</accession>
    <name>E9H9B5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_308759</name>
        <name evidence="4" type="ORF">DAPPUDRAFT_338194</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734145">
        <property type="protein sequence ID" value="EFX61770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
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    </evidence>
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</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Andrews J."/>
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                <person name="Lucas S.M."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <location>
            <begin position="222"/>
            <end position="242"/>
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        <location>
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        </location>
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            <end position="116"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX70852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="244" mass="28267" checksum="18E89855CF99DF9F" modified="2011-04-05" version="1">MDAERNDEAKLSVRSNYSPFASTARQSSSPGHSQFRQLLPSNSSARNDAERNDAERNDAAKLSGLSNYSPFASTSRQSSSPGHLQFRQLLPSNSSVRFDAKRNNVARKDAERNDYETTENNSFFTNSNSRKFTVQQQQVKPLEPHREHNTQQEALNYSNLKERVNILERELVEEKRLRWEREDNFRRNPLVLRNQHMELVRGENPNVNDFLKRSKDQSETSIILPIVMAIYVATVMVTHLLFLW</sequence>
</entry>
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    <accession>E9HBT3</accession>
    <name>E9HBT3_DAPPU</name>
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        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732617">
        <property type="protein sequence ID" value="EFX70772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70772">
        <property type="protein sequence ID" value="EFX70772"/>
        <property type="gene ID" value="DAPPUDRAFT_8361"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_8361"/>
    <dbReference type="eggNOG" id="ENOG502RYRA">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <reference evidence="2 3" key="1">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
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                <person name="Frohlich T."/>
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        <location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Basu M.K."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="121"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX69452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="381" mass="42892" checksum="0980DF5EE78CF017" modified="2011-04-05" version="1">MVHQAEPARMEIIPSIASSLSRQQEESKIVVEDQGSTVAIDSNTVDQRSKPIERSIQDAEKKKIAELFTQEEFAKLLKVDQPMVYQLNTKERSVGENLRYFDIPGTDTASSSQNSQNRKVIILMGSTGSGKSTLINGMINYILGVQWKDPFRFKCVREDSSVVRDEAHSQTDSVTAYTLHHREGMAIPYSITLIDTPVYGDTRGIERDKKITGCIHRFLTQQQGFKIDQIHAIGFVAASADSRLTPTQRYVLDSVLSIFGKDVKENIRLLVTFADNATPPVVEACRAAHFPMTSPSGGVMYNKFNSSVLYASNEKNGTDDLSIDEIFWKMGQRNYKSFFTMLENINGRDLKSTRLVIENRQLLEKSLPDIEVELEICFDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9HG29</accession>
    <name>E9HG29_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Cytidine deaminase</fullName>
            <ecNumber evidence="5 9">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_202914</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3 9">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="5 9"/>
    <dbReference type="EMBL" id="GL732638">
        <property type="protein sequence ID" value="EFX69330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69330"/>
    <dbReference type="EnsemblMetazoa" id="EFX69330">
        <property type="protein sequence ID" value="EFX69330"/>
        <property type="gene ID" value="DAPPUDRAFT_202914"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_202914"/>
    <dbReference type="eggNOG" id="KOG0833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_1_2_1"/>
    <dbReference type="InParanoid" id="E9HG29"/>
    <dbReference type="OMA" id="CGACRQS"/>
    <dbReference type="OrthoDB" id="1400471at2759"/>
    <dbReference type="PhylomeDB" id="E9HG29"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047844">
        <property type="term" value="F:deoxycytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009972">
        <property type="term" value="P:cytidine deamination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="15"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX69330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="148" mass="16105" checksum="B395AE0F988D8C94" modified="2011-04-05" version="1">MGDCDEEVDFDLLDPAIQKIINKAKAVREKAYCPYSKFAVGAALLCDDGAIIDGCNVENVSYGLTICAERSAICKAMSEGQKVFNSIAICAEMKDKFVGPCGACRQVLAEFNVNLDVYLCKPNNEILKTSMAKLLPLSFTPNWVSFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGJ5</accession>
    <name>E9HGJ5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (cytosine(34)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.203</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_329423</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.203" evidence="2"/>
    <dbReference type="EMBL" id="GL732642">
        <property type="protein sequence ID" value="EFX69093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69093"/>
    <dbReference type="EnsemblMetazoa" id="EFX69093">
        <property type="protein sequence ID" value="EFX69093"/>
        <property type="gene ID" value="DAPPUDRAFT_329423"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_329423"/>
    <dbReference type="eggNOG" id="KOG2198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_4_3_1"/>
    <dbReference type="InParanoid" id="E9HGJ5"/>
    <dbReference type="OMA" id="QLFTEYV"/>
    <dbReference type="OrthoDB" id="911098at2759"/>
    <dbReference type="PhylomeDB" id="E9HGJ5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="PTHR22808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX68489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX68489"/>
        <property type="gene ID" value="DAPPUDRAFT_260052"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="127" mass="14545" checksum="9665EADBE03C8E3F" modified="2011-04-05" version="1">MDGSLKPSTFKFRHVIDTDTDVMAESATTAANRWRQSSPIRSPWDVKQRLSLTKWVTLAEAALNSQERRIAEAITIKDRERTGNRLWLSAIVESVTSFYSPARNPFFRFSRSTPQHTNNDDNIGSRM</sequence>
</entry>
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        <name type="scientific">Daphnia pulex</name>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX68044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX68044">
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        <property type="gene ID" value="DAPPUDRAFT_330465"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330465"/>
    <dbReference type="eggNOG" id="KOG3652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="PhylomeDB" id="E9HJM7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
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        <property type="project" value="GO_Central"/>
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    </dbReference>
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        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="1442"/>
        </location>
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        <location>
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            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX68044.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1464" mass="162445" checksum="203363BB9CFEE221" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HL34</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
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                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_115354"/>
    <dbReference type="HOGENOM" id="CLU_897920_0_0_1"/>
    <dbReference type="OMA" id="NAFAFTE"/>
    <dbReference type="PhylomeDB" id="E9HL34"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="310" mass="35743" checksum="A21B1764A8B85558" modified="2011-04-05" version="1">MDTKKPEYCRNKKKDDPILADNQFFVKEEPHMSWEGYVCKAWLKRKTIDGFFFGGFDTVFSSEIQQLSENDCWRMKQTKRCGENEMVGDENQFPFTSTPNGEGVRMQKVSFTTENCMVQKISLKKDCATCPTTSPFGILKEKPRETFVYHKDSVIVWIQPKRDLEKECKIKIKRKSTGTITKIDDNTYKLVDAPGQLDYIYTAETQNICDFTLHKLKNVDGAYLQPPRIIPMAPGSPPPPDYYGRHLPPSYDSLYGLPTTRRLPDFLQEHQQVQRELMELTEKLLETQARLPYTSKTVSASSGVSTEILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HL52</accession>
    <name>E9HL52_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_330977</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732675">
        <property type="protein sequence ID" value="EFX67548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67548">
        <property type="protein sequence ID" value="EFX67548"/>
        <property type="gene ID" value="DAPPUDRAFT_330977"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330977"/>
    <dbReference type="HOGENOM" id="CLU_2529708_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="84" mass="9410" checksum="CF460FFF2EEB6405" modified="2011-04-05" version="1">MIQAFLFSKVTQIVPVPRYYRGTFTATVIATALFEKNYRSTATALLFQSTAFNTDLNINVRPANNLILCVVENGLPPKKVMKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLJ8</accession>
    <name>E9HLJ8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_34 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_331123</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732679">
        <property type="protein sequence ID" value="EFX67403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67403"/>
    <dbReference type="EnsemblMetazoa" id="EFX67403">
        <property type="protein sequence ID" value="EFX67403"/>
        <property type="gene ID" value="DAPPUDRAFT_331123"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_331123"/>
    <dbReference type="eggNOG" id="KOG1513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_728179_0_0_1"/>
    <dbReference type="InParanoid" id="E9HLJ8"/>
    <dbReference type="OrthoDB" id="141580at2759"/>
    <dbReference type="PhylomeDB" id="E9HLJ8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048583">
        <property type="term" value="P:regulation of response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026741">
        <property type="entry name" value="SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039187">
        <property type="entry name" value="SNO_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706">
        <property type="entry name" value="PTHR12706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13872">
        <property type="entry name" value="AAA_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_34" evidence="1">
        <location>
            <begin position="11"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="380" mass="44020" checksum="0A6E6AC476E7DAC6" modified="2011-04-05" version="1">MNKQEIARRIMMKRHTQRLPGGSRAGFLLGDGTRVGKGRIAAAIIFENFLRGRKNSIWLSVSNEHKYDAKWDLRDIGTDQIAFHHLYTSKRSLVSAGDVFGSVKEGVVFSTFFNLTEFSYFRKKYQSSLYEWFDWCGQDFNGVIIVDECHQTKKQFYNNVRTGTNIECAVLKLQARLQNARIVYMCATGISEPINMGYMTRLGLWGQGTAFHAFEDMGCMELVGMEKQGGMYLALQLSFEDVVFDIFEVDVDQNLVKIYDQSVALWEEFLKSSHRSFTEAENRQTIDRDAHRTFWLHFWAAHSDFFKYLCISAKIRDAALMAQQAGKDGKSWSSYFNLEAQNVLLEYRVDFAEVSRNLRKYGMWKKPMECLSSARMMRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLV2</accession>
    <name>E9HLV2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_64017</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732682">
        <property type="protein sequence ID" value="EFX67278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67278"/>
    <dbReference type="EnsemblMetazoa" id="EFX67278">
        <property type="protein sequence ID" value="EFX67278"/>
        <property type="gene ID" value="DAPPUDRAFT_64017"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_64017"/>
    <dbReference type="eggNOG" id="KOG1588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1027653_0_0_1"/>
    <dbReference type="InParanoid" id="E9HLV2"/>
    <dbReference type="OMA" id="RPVDETH"/>
    <dbReference type="OrthoDB" id="1565749at2759"/>
    <dbReference type="PhylomeDB" id="E9HLV2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031119">
        <property type="entry name" value="GLD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032377">
        <property type="entry name" value="STAR_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="PTHR11208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF125">
        <property type="entry name" value="PTHR11208:SF125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16544">
        <property type="entry name" value="STAR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="1">
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="142" mass="16212" checksum="8108EB66BB9BF30A" modified="2011-04-05" version="1">MKGKTTRETRECGNRGAGRLSNGVFLFGANHPLHDPHQQRLRSKTKIPILVGKPPHLRDEEEAAKKAQEAIDVMRAESAMGEESMMVNSRKLKYYEETKNILHGIFRDDQEKSTQLDLTTARNVICQETYVNSVDFENILQQ</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
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    <feature type="chain" id="PRO_5003238455" evidence="1">
        <location>
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            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="59" mass="7137" checksum="8285CE45902C9732" modified="2011-04-05" version="1">MCDTFSTRRTLMLPRPWIILLLANHIVQAYDLQMSPKLENDEQEFRKRHHVETLKNETQ</sequence>
</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_115995"/>
    <dbReference type="eggNOG" id="ENOG502SUNW">
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    <dbReference type="InParanoid" id="E9HN78"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="PhylomeDB" id="E9HN78"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="315" mass="34804" checksum="93EC49D2A7FEDB96" modified="2011-04-05" version="1">MPICYKHSLLLALNPPSSASPGFPLISSCRCQPHAYCSTDPLPGRRAFRTLPFHRVMVHLAAATPLLNARSIQNKDVLLADICDDVRPDFFAITETWLTPEHGDSVLMKSCPDGYTALHRPRTSTRAVYRILVIHLSSIFLSLRPRPIPLIIMYRPASKSSSAFLDEFAKLLDAVVLSDASFLIVGDLNYHVDGLSDPSVRNFVHLIESLWASAVFQLSNPHAWSHIDLVIARAADNLIDDVSTGSFFSEEASVFCSIPYCLPPCPTKRLTFSSYKSFSLDSFLSDLSALPLIVEPSTSLNLLVEQYNGGLRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPF7</accession>
    <name>E9HPF7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="6 8">Nucleus</location>
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        <property type="protein sequence ID" value="EFX66374"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
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    </dbReference>
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        <property type="entry name" value="LIM"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 7" id="KW-0440">LIM domain</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="59"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="220"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
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            <end position="281"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="228"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <end position="183"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
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            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
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    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX66374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="349" mass="38316" checksum="239B7A694FBAA482" modified="2011-04-05" version="1" fragment="single">CAGCDRAILDKFLLTVLDRTWHAECVRCADCRNILAERCFSRDGKLYCRTDFFRRYGTKCGGCGQGLSPTDLVRKARDKVYHLRCFTCALCRRQLSTGEELYLLDDARFLCKEDFIRGKAAPANITSLSSPICGRADEDGLTMPSPNRPLTPMTQGLIIAPPPSSDGIVIKTQRPSTPSNTIDDKDGNDSEGSVDGDGEGESRSDNPSESKSPDEGGAGSKRRGPRTTIKAKQLEILKNAFSQTPKPTRHIREQLAKETGLPMRVIQVWFQNKRSKERRLKQLTSMGLRPYFGASRKLRGFPVSPGMDDGSGVVGGFNPYFDPKYAADFAYGGAPGGPHPHFGLHSHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPJ9</accession>
    <name>E9HPJ9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_332291</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732708">
        <property type="protein sequence ID" value="EFX66277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX66277"/>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_332291"/>
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    <dbReference type="PhylomeDB" id="E9HPJ9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX66277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="144" mass="16169" checksum="5364B705C6BA6C4B" modified="2011-04-05" version="1">MKLDNKYADITITSQSDERNLDGSSQWSYAQSDYTTREESQVQKKMQGVKYDSYGKATYEDVMGNTNKGSSYWVSPEGEKFTLTWAADEEGFKPKGDHLPVAPVHVYELPVAPVHEYVLPVAPVHEYELPVAPALPYKRTGAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>E9HQF5</accession>
    <name>E9HQF5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_204203</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="GL732719">
        <property type="protein sequence ID" value="EFX66029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66029"/>
    <dbReference type="MEROPS" id="M12.011"/>
    <dbReference type="EnsemblMetazoa" id="EFX66029">
        <property type="protein sequence ID" value="EFX66029"/>
        <property type="gene ID" value="DAPPUDRAFT_204203"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_204203"/>
    <dbReference type="eggNOG" id="KOG3714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005140_0_0_1"/>
    <dbReference type="InParanoid" id="E9HQF5"/>
    <dbReference type="OMA" id="RTVQTIN"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="term" value="P:dorsal/ventral pattern formation"/>
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        <property type="term" value="P:protein processing"/>
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        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="ZnMc_BMP1_TLD"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="5"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BMP_1/tolloid-like"/>
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        <property type="entry name" value="CUB_dom"/>
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        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
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        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
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        <property type="entry name" value="EGF_Ca-bd_CS"/>
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    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
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    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ZnMP_TLD/BMP1"/>
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        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001199">
        <property type="entry name" value="BMP_1/tolloid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASTACIN"/>
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    </dbReference>
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        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="SSF49854"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="12">
        <location>
            <begin position="29"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="10">
        <location>
            <begin position="232"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="10">
        <location>
            <begin position="349"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="461"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="10">
        <location>
            <begin position="504"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="10">
        <location>
            <begin position="662"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="10">
        <location>
            <begin position="775"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 8">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="94"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001199-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001199-2"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX66029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="909" mass="102496" checksum="12256AC592881154" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9HQL6</accession>
    <name>E9HQL6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_65101</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732722">
        <property type="protein sequence ID" value="EFX65948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX65948"/>
    <dbReference type="EnsemblMetazoa" id="EFX65948">
        <property type="protein sequence ID" value="EFX65948"/>
        <property type="gene ID" value="DAPPUDRAFT_65101"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_65101"/>
    <dbReference type="eggNOG" id="KOG0019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_0_3_1"/>
    <dbReference type="InParanoid" id="E9HQL6"/>
    <dbReference type="OMA" id="MPRSETK"/>
    <dbReference type="OrthoDB" id="924636at2759"/>
    <dbReference type="PhylomeDB" id="E9HQL6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX65948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="135" mass="14891" checksum="8C4869906FC23F79" modified="2011-04-05" version="1" fragment="single">LISNFSDALDKIRYESLTDSSKLDSSKDLEIKIVPTRMTVLSWIRHGIDMIKADLVNNLGTIAKSGTKAYMEALSAGADISMICQFGVGSYSAYLVADKVTVHSKHNDDEQYVWESSAGCSFTIKPDHGEHMSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9HRE2</accession>
    <name>E9HRE2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_117059</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732734">
        <property type="protein sequence ID" value="EFX65688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65688">
        <property type="protein sequence ID" value="EFX65688"/>
        <property type="gene ID" value="DAPPUDRAFT_117059"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_117059"/>
    <dbReference type="HOGENOM" id="CLU_057581_1_0_1"/>
    <dbReference type="PhylomeDB" id="E9HRE2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="257" mass="28522" checksum="E2F349C5775C959E" modified="2011-04-05" version="1">MARGRKSKAATASQNDNTVASRLRSRTVPANVKNISRVPQPETIERDATRKQIQMTCSCIDKLIKERGSRRACLGLLNKLDDMLATVERLNLLVVDPSDADEFSKQAQIQIDLFTLIESKKEDVEAYVTLRADDESSVGSCMQSIKGVPLATRPSAPDNEKSKKLLAEAQKRAAEAQQEAAQLQKRLEEVNKKADLANKEASKQSDAAMRRGSAPTIISNPFHGWGDGGIDDWHRRSTHEPTKEDGEEEAPDDWIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9HTS3</accession>
    <name>E9HTS3_DAPPU</name>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_65881</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732783">
        <property type="protein sequence ID" value="EFX64863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX64863"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_65881"/>
    <dbReference type="eggNOG" id="KOG2391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017548_1_1_1"/>
    <dbReference type="InParanoid" id="E9HTS3"/>
    <dbReference type="OMA" id="YMNFPQP"/>
    <dbReference type="OrthoDB" id="1435538at2759"/>
    <dbReference type="PhylomeDB" id="E9HTS3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="SSF140111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="9">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="8">
        <location>
            <begin position="324"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="241"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX64863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="390" mass="43275" checksum="3E9E236EF3FF77D2" modified="2011-04-05" version="1" fragment="single">LQYYKNPEKAKRDVQNLLQHYRGLQPKVETFVFNDGASKQLLCLGGTIPVHYKGSDYNIPVALWLLETHPVNAPMVFVRPTSDMRLRISKHVDHNGKVYMPYLHVWSANESDLVALVQVMIIIFGEQPPVYSVAGQPPSNPAAAYPGSLAGYPPYPTSATAYPPATPYPQYPPVNGPASTSYPSYSGGYPPYPPAPGTITSSAAYPPYPTPAGVPNAQSTGTISEDHIRASLLSAVEDKVRRRLSEIFAQAQAEIETLKKTENELRMGQSKLEDLGRRLDQEQNEVERSIASLKERNSELEDSLGKLKSQDKNFDVDEAVVTTAPIYKQLLNAYAEEAATEDAIYYLGEGLRRGVTELDVFLKNVRSLSRKQFMLRALMERCRQQAGLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HUK5</accession>
    <name>E9HUK5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732812">
        <property type="protein sequence ID" value="EFX64579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64579">
        <property type="protein sequence ID" value="EFX64579"/>
        <property type="gene ID" value="DAPPUDRAFT_118061"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_118061"/>
    <dbReference type="eggNOG" id="ENOG502RTCC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1195906_0_0_1"/>
    <dbReference type="InParanoid" id="E9HUK5"/>
    <dbReference type="PhylomeDB" id="E9HUK5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX64579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="232" mass="26599" checksum="8CA87125FE28C06B" modified="2011-04-05" version="1">MKTKMCIVRPSSPWFSGEISAARRRCRKLERVWRRRRLTIDKDILLHHIRQLRKLMNDTKASFFKSKIDEMGNDRRGLFQLLDRCLSRDKVSKLPVHADPATLADRFGRYFDEKIVNIRANLDAKNAPSADSSSSAPNSFLSVFELVLPAEICEIVDKCPANTQKKGLKRYEFTNAVQKAGRSLFEARDFGSRTTQKSLTITLGVPHATDTLVTAENDRQVQYLGRISNRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9HVG8</accession>
    <name>E9HVG8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_118339</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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        </citation>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
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        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021174"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX61270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="179" mass="18983" checksum="06095E7D5B85806D" modified="2011-04-05" version="1" fragment="single">GTYSGQYLFCGRKATVATGNVLPVNQISEGTTICNIESSVGDKGSYSRCSGTYATIVGHSDDGTKTRIRLPSGSRKTIPGLCRATVGIIAGGGRNEKPIMKAGVLFHKFKRQRKRFPKVAGVRMNPVDHPHGGGNHKHLGKPGTVSRYASAGQKVGLIAARRTGLIRGTKTVKNAPEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61183">
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        <property type="gene ID" value="DAPPUDRAFT_122456"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_122456"/>
    <dbReference type="HOGENOM" id="CLU_1847156_0_0_1"/>
    <dbReference type="OrthoDB" id="1855623at2759"/>
    <dbReference type="PhylomeDB" id="E9I497"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="139" mass="16162" checksum="8D46297FD36F402C" modified="2011-04-05" version="1">MAFKWKRQVRGLVFKFGEKLDDTFCDSYAVVLWRNTEPTPYNCIDIDHILNPDMLTNQDIYGLVPVSVYEQKGYSDTEVIRTFYGRVLATGSDKDILRSLAEAEWCRLRQLGVSRKELPTGDEFEGHVCTFLQNLPKYR</sequence>
</entry>
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    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_340541"/>
    <dbReference type="eggNOG" id="ENOG502RWEX">
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    </dbReference>
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    <dbReference type="InParanoid" id="E9I4C3"/>
    <dbReference type="OrthoDB" id="279711at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="156" mass="17760" checksum="08E5A68DBCCDF0CB" modified="2011-04-05" version="1">MKEIPLSAEPGAKRRKDRLSVPDEIRFSQVGIHHPIFVENRGRCEWCQATTERRPNGFTKESRPFSQCSMCKIFLCLSKKRNCFLEFHDDRILNPTKAAAETVLAVDPEEEIAVQTVETDPLGIYPSSDSSDDSDFDVLDNDVNDGVLLDEDEWLK</sequence>
</entry>
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    <name>E9I503_DAPPU</name>
    <protein>
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    </protein>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL735309">
        <property type="protein sequence ID" value="EFX60927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60927">
        <property type="protein sequence ID" value="EFX60927"/>
        <property type="gene ID" value="DAPPUDRAFT_122717"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_122717"/>
    <dbReference type="HOGENOM" id="CLU_121603_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="145" mass="16610" checksum="C51046302C8D1F3A" modified="2011-04-05" version="1" fragment="single">MRLARYPKVWQQEQGADECCMTMFHREFWIAFATTLVWLIKSDKLCCCFFYLNHIEHESSSLTLQVDCLRRVIQSGLSSRGKAFTSIEAERVGVSREVAVCRLTCSWTKISVTSPWAHRQQMVRSSAEHSSVNLGEVHKKANGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9I6I9</accession>
    <name>E9I6I9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_344050</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX89369.1"/>
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    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX89369">
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        <property type="gene ID" value="DAPPUDRAFT_32537"/>
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    <dbReference type="eggNOG" id="KOG1331">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="term" value="C:nucleus"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="entry name" value="Trm9"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="35"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX89369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="135" mass="15574" checksum="E41DD93597D38C1F" modified="2011-04-05" version="1" fragment="single">VYDQLSHHFSEERYRPWPRVRQFLEQLEPGSLVCDAGCGNGKYLQVNPSIFKVGSDRCAASVDVARRKDHEVLICDALNLPYRDESFDAALSIAVIHHLATRDRRVRALRELARILRVGGRILITVWAKEQRHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9FTJ5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_94951</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Eukaryota</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_94951"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2040402_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236363" evidence="1">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="121" mass="13706" checksum="C678ED819A3843B2" modified="2011-04-05" version="1">MGRLALLMLCLSICLSYYASVSANQERDSRFWFRPSGKNDRCNRYNQLCPKLVFQQQVVPQVVQQQVVPEVVQQQVVPQVVQQQAVPEVVTQVPQVVQQQDATGAVPQQVVNVPVTQEDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9FU98</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX88690"/>
        <property type="gene ID" value="DAPPUDRAFT_310995"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2924907_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX88690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="63" mass="7204" checksum="370B7660C8D4C6AF" modified="2011-04-05" version="1">MLKMMKLEASRFGNHAFHQILIPEAEKPLTCTTFFKGPFTMWNFTLAICSLSSNCADLCCERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9FWP8</accession>
    <name>E9FWP8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_6759</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88394"/>
    <dbReference type="EnsemblMetazoa" id="EFX88394">
        <property type="protein sequence ID" value="EFX88394"/>
        <property type="gene ID" value="DAPPUDRAFT_6759"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_6759"/>
    <dbReference type="eggNOG" id="KOG4229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2216409_0_0_1"/>
    <dbReference type="InParanoid" id="E9FWP8"/>
    <dbReference type="OMA" id="HIFAYAD"/>
    <dbReference type="OrthoDB" id="1610755at2759"/>
    <dbReference type="PhylomeDB" id="E9FWP8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035487">
        <property type="entry name" value="MYO15A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF21">
        <property type="entry name" value="PTHR22692:SF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 5" id="KW-0518">Myosin</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="6">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX88394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="107" mass="12053" checksum="88D7EBE218B2D8D7" modified="2011-04-05" version="1" fragment="single">QGEMVWFDPCNLGYLLPGVVTEYHRSAQVVTIQSAANLTNKPQTFTLTNLSSLRRREDLGKGGVEDMISISDLNEASLLWNLKVRYDGQHIYSYTGNILVSVNPYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXA4</accession>
    <name>E9FXA4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KH_dom_type_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_7657</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88303"/>
    <dbReference type="EnsemblMetazoa" id="EFX88303">
        <property type="protein sequence ID" value="EFX88303"/>
        <property type="gene ID" value="DAPPUDRAFT_7657"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_7657"/>
    <dbReference type="eggNOG" id="KOG1588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065679_3_0_1"/>
    <dbReference type="InParanoid" id="E9FXA4"/>
    <dbReference type="OMA" id="MIFANSN"/>
    <dbReference type="OrthoDB" id="1012406at2759"/>
    <dbReference type="PhylomeDB" id="E9FXA4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="PTHR11208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH_dom_type_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="88" mass="10161" checksum="0F62AA978664DBCD" modified="2011-04-05" version="1" fragment="single">FNFVGKLLGPKGNSLKRLQEETLTKMAILGRGSMRDKHKEEEYRHSHEPRYRHLNDDLHVEITAYAAPAEAHARIALALTEIRRFLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXW9</accession>
    <name>E9FXW9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_230342</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UBALD family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88175"/>
    <dbReference type="EnsemblMetazoa" id="EFX88175">
        <property type="protein sequence ID" value="EFX88175"/>
        <property type="gene ID" value="DAPPUDRAFT_230342"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230342"/>
    <dbReference type="eggNOG" id="ENOG502S43S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108623_1_0_1"/>
    <dbReference type="InParanoid" id="E9FXW9"/>
    <dbReference type="OMA" id="WIQGEPP"/>
    <dbReference type="OrthoDB" id="1581701at2759"/>
    <dbReference type="PhylomeDB" id="E9FXW9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039310">
        <property type="entry name" value="UBALD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31993">
        <property type="entry name" value="PTHR31993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="141" mass="15302" checksum="0E98B6ADB54DFCB5" modified="2011-04-05" version="1">MDSLREQVMINQFVLAAGCAREQARQLLQAAHWQFETALSIFFQEVSVANCGGGGHAHHLHYNQLCTPANTPATPPNFPDALAAFAKLSASDKYGTSPGIYSTSPNPTAAYLTSQHMHGYGAQQMPLQPQQHQQQAGHRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9FY74</accession>
    <name>E9FY74_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_235084</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
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    <sequence length="1067" mass="118971" checksum="EEFFFC1D0B300DDB" modified="2011-04-05" version="1"> </sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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        </location>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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    <protein>
        <submittedName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
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        </cofactor>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX84950">
        <property type="protein sequence ID" value="EFX84950"/>
        <property type="gene ID" value="DAPPUDRAFT_314561"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_314561"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="182" mass="20257" checksum="33B52ACE15B630AF" modified="2011-04-05" version="1">MFSLDDEDTSQSEITSFEVSEMSRNQYSINCESDEKISKNKSEIYRRLEINKNVFTTDPNDTSATAASTSRFDNLILNGSVSVPTSSFMISDQYINDEVETVKIVNSPVCQEEMGDELLVEFETIDLAAASSVIATENRCDNWPSAVDQRKRRCVLAVVIASVAGVTIVIVIIVLLTFNLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6N3</accession>
    <name>E9G6N3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_314297</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX85163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85163"/>
    <dbReference type="EnsemblMetazoa" id="EFX85163">
        <property type="protein sequence ID" value="EFX85163"/>
        <property type="gene ID" value="DAPPUDRAFT_314297"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_314297"/>
    <dbReference type="eggNOG" id="KOG1966">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_323456_0_0_1"/>
    <dbReference type="InParanoid" id="E9G6N3"/>
    <dbReference type="OrthoDB" id="389547at2759"/>
    <dbReference type="PhylomeDB" id="E9G6N3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071805">
        <property type="term" value="P:potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0915">Sodium</keyword>
    <keyword evidence="6 7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240922" description="Sodium/hydrogen exchanger" evidence="10">
        <location>
            <begin position="19"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="11">
        <location>
            <begin position="101"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX85163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="894" mass="98523" checksum="4B18668DEB926463" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9G807</accession>
    <name>E9G807_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC2_membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_314580</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84770"/>
    <dbReference type="EnsemblMetazoa" id="EFX84770">
        <property type="protein sequence ID" value="EFX84770"/>
        <property type="gene ID" value="DAPPUDRAFT_314580"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_314580"/>
    <dbReference type="eggNOG" id="KOG0059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014367_0_0_1"/>
    <dbReference type="InParanoid" id="E9G807"/>
    <dbReference type="OMA" id="FIGAICK"/>
    <dbReference type="OrthoDB" id="433226at2759"/>
    <dbReference type="PhylomeDB" id="E9G807"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="242"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX84770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="457" mass="50637" checksum="B9873E1462B30101" modified="2011-04-05" version="1">MTNDAEGSVASLQSHQLGNATNISASDSGVLVSNATKIYGAGSKRCAVLKGLNMSVKNGTMIVLFIYLLPPFLSTVFNATLGHDPTGLKLAIVNDELDPSQGRICSSNTTDCTYSMLSCRYLHYIKDKIIQVPYDNVSEALEAGRNGQVWGVIHFGHNFTEEFEIRQDAGDSATLENIIRSRITVNMDLSNQIIYSSIEKWILEAFEDFYKDFMRSCGHEPEAGFIPLEFLDPIYGQNNTPFTEFMAPALIISLVYFMGVSLTAGVFITEKQQGLLDRNLVAGVQMTEVLMSHLVNHFTAMIGQTALVYLVVLLIFSITCQGNFGLAVFITFLQSFVGMSFSLLIATVCEDEIGALLLSQGSFLPLTVISGFGWPIEGMSFYLRYIAYSSPMTYAVESLRSVFNRGWGIEQTDVYVGILISIAWIFALLSLCELVHLSTAFNNLDREEIKEEDYYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8D2</accession>
    <name>E9G8D2_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_99811</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84294">
        <property type="protein sequence ID" value="EFX84294"/>
        <property type="gene ID" value="DAPPUDRAFT_99811"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_99811"/>
    <dbReference type="HOGENOM" id="CLU_1519381_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX84294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="177" mass="20388" checksum="BC9658D6C6191DED" modified="2011-04-05" version="1">MYLHFCCPQIDAAMRRPQLPTQFKVASRSYKDTNDLVPEWHWVGREVCRHRVVHDIQQSQHSRINLKLSKMIILQRKKLPALISLKYSGYLKMPMMREINELPPPSQNFQLRIGIRPAALPKMSASFTPDLTKEAALTSSRATVTSASLCSHSQKKVLRDNLFSTMGLKRSRNQSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8R4</accession>
    <name>E9G8R4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_27414</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84224"/>
    <dbReference type="EnsemblMetazoa" id="EFX84224">
        <property type="protein sequence ID" value="EFX84224"/>
        <property type="gene ID" value="DAPPUDRAFT_27414"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_27414"/>
    <dbReference type="eggNOG" id="KOG1346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2729506_0_0_1"/>
    <dbReference type="OrthoDB" id="830428at2759"/>
    <dbReference type="PhylomeDB" id="E9G8R4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX84224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="81" mass="8691" checksum="386AF2ED9138B704" modified="2011-04-05" version="1" fragment="single">TDHVVSVVGWNANTDLAVASGLEIDSNFGGYGVNTELEARSTVWLVGDAAFLCDIKLVRRRMEHSYHAVVSGRLAGENNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8S4</accession>
    <name>E9G8S4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84217">
        <property type="protein sequence ID" value="EFX84217"/>
        <property type="gene ID" value="DAPPUDRAFT_99924"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_99924"/>
    <dbReference type="HOGENOM" id="CLU_097676_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9G8S4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240715" evidence="1">
        <location>
            <begin position="22"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="211" mass="22450" checksum="F25B76E129766E6E" modified="2011-04-05" version="1">MAFPTSLFLVATVCCLTIVNAAGETLRPLPSDANNRQQFNQQMFMVAPPHLGYNQYHPYGGQAMMQPSAGGFYPYYPFAAGWRYPSVDQGGFTKLELSDRAARDPIIIGPAAAECASGTIEADGIGPCVKTSGAKRGSISIKLPIADQTAVVAIVRSSTSRITLRCSEMNAVAAFTQTGKIADKSVVRTETGVMQLVVTSTGDNGVMKCTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E9GA53</accession>
    <name>E9GA53_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_301653</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX83766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="6669.EFX83766"/>
    <dbReference type="EnsemblMetazoa" id="EFX83766">
        <property type="protein sequence ID" value="EFX83766"/>
        <property type="gene ID" value="DAPPUDRAFT_301653"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301653"/>
    <dbReference type="eggNOG" id="KOG1080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020840_0_2_1"/>
    <dbReference type="InParanoid" id="E9GA53"/>
    <dbReference type="OMA" id="RERRYIS"/>
    <dbReference type="OrthoDB" id="1234689at2759"/>
    <dbReference type="PhylomeDB" id="E9GA53"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone methyltransferase activity (H3-K4 specific)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051568">
        <property type="term" value="P:histone H3-K4 methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="164"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="6">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX83766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="303" mass="34300" checksum="9E3E8F6550E90A71" modified="2011-04-05" version="1">MAYFYEFLAKGIDAEDISYFHKSYETLLSQDALQTQGYWLNDTHWVDYDPTELDPSPSKRKRKEEPRPHKSGSARTEGYYKLDSKEKAKHKSHFARCVTEDSRLAESNVSSVRAAGLGPTDTGINKGQALSREARSNQRRLLTAFGLENDSDLLKFNQLKFRGAKLKFGKSSIHDWGLFAVESIAADEMVIEYVGQVVRPVLADLRETQYEAVGIGSSYLFRVDLEYIIDATKCGNLARFINHSCNPNCYARVITIESQKKIVIYSKQPIGVGEEITYDYKFPIEEDKIICLCGSSQCRGTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9GA73</accession>
    <name>E9GA73_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_301660</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83692"/>
    <dbReference type="EnsemblMetazoa" id="EFX83692">
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        <property type="gene ID" value="DAPPUDRAFT_301660"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301660"/>
    <dbReference type="eggNOG" id="KOG1262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="WFWIHAK"/>
    <dbReference type="OrthoDB" id="733611at2759"/>
    <dbReference type="PhylomeDB" id="E9GA73"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="PTHR10801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="51"/>
            <end position="231"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="505" mass="58467" checksum="D514AD1929427073" modified="2011-04-05" version="1">MSRKTENGHGGQESQTSKIPADKSWLAYILINYRWVFVCFFLLPLSLVYDIYHLARSWIIFKLNSAPKKHDERVKFVQKQVREWNQQGRNTPMCTARPGWQTISFRQPKYKKTLFNVKVNLMDVLEIDTERKTVRVEPLVSMGQLSATLNPLGWTIPILPEMDDLTVGGLIMGTGIETSSHKHGLFQHICVSFELVVADGSVVKCSKSYGTLGFLTAVEIEIVPSLQFVRLEYKSVSSLDEACRVFEEETLKEENNQFVEGLMFSLNRGVIMTANMVNSAEPGKLNVISMPWFFKHVESFWGLEETQVEYIPTRDYFHRHSRSIFWEIQDIIPFGNHPVFRYLFGWMVPPKVSLLKLTQGDTVKELYENNHFIQDMLVPMSNLKDALLCFEKEVKIYPVWLCPFKLPKAPGMLRSPSGKQELYVDIGTYGVPKVSNFHPVETTRRVESFVRSVKGFQMLYADSYMTEEEFHSMFDHTLYNQMRKKYDCDKAFPRVYGKVSRAARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAG0</accession>
    <name>E9GAG0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_301979</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
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    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
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        <property type="gene ID" value="DAPPUDRAFT_52079"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
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        <property type="term" value="P:trehalose metabolism in response to stress"/>
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    </dbReference>
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        <property type="entry name" value="Glyco_trans_20"/>
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        <property type="entry name" value="Trehalose_PPase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX79930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="819" mass="91806" checksum="2A162CC953E0E608" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKR7</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_304278</name>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732550">
        <property type="protein sequence ID" value="EFX79727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="12"/>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX79727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="91" mass="9574" checksum="4F5A7BB8E490857E" modified="2011-04-05" version="1">MLLDLDNVKGKCLAFGVVIFIVLVIVIITGLTSPSGSGKWPSPSNSSDMDAVHNGTNEEPFMLGAIGQYGSNRNTIGVDKTGHIKTKWGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GL23</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_319222"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5003237539" evidence="1">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX79867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="102" mass="10779" checksum="8BC373984B9634A5" modified="2011-04-05" version="1">MKFVVVLASLSLALTAAVEVNVKPKTESNVEVSDQDLAEVNGTDVVISVDIVILAWTSVCRGDATGTRSQHRSCRKLLTRRQSSSVAATTVNILAIGVVVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9GLJ5</accession>
    <name>E9GLJ5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DC_STAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_319375</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Diplostraca</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732551">
        <property type="protein sequence ID" value="EFX79681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79681">
        <property type="protein sequence ID" value="EFX79681"/>
        <property type="gene ID" value="DAPPUDRAFT_319375"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_319375"/>
    <dbReference type="HOGENOM" id="CLU_059080_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GLJ5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012858">
        <property type="entry name" value="DC_STAMP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07782">
        <property type="entry name" value="DC_STAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DC_STAMP" evidence="6">
        <location>
            <begin position="83"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX79681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="295" mass="34768" checksum="28F7C189D2F5C11C" modified="2011-04-05" version="1">MSSLEVHSRFFTVEQKLRVWMKKSLYTSFTRVMFDYIYIMYNYPSRFAESVRLIIKVMFCFWFEQSAKYLHHLLMNIQFVVPNYGSARFVFNVQGNGIFAVLMRAVLGGFSLESKYCKIADTSACNTAFIPVDWRTWVMLFLLAFFYFLIGLYQSKSDYIMCRICDFLIPKRGEERTEVTLEEINEERRKRSVVVEKLAEEEIKHPCFDRGQNDAIISFYQPRRWYHRFMPTLILSLIAHWKLGVDSILCQICGQDIITGRFRCKTLLFCEECQCQLTCCPCGSDACQDGIIFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9GMP6</accession>
    <name>E9GMP6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_304938</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732553">
        <property type="protein sequence ID" value="EFX79133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79133"/>
    <dbReference type="EnsemblMetazoa" id="EFX79133">
        <property type="protein sequence ID" value="EFX79133"/>
        <property type="gene ID" value="DAPPUDRAFT_304938"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304938"/>
    <dbReference type="eggNOG" id="KOG1259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029070_0_0_1"/>
    <dbReference type="InParanoid" id="E9GMP6"/>
    <dbReference type="OMA" id="DNEKPNQ"/>
    <dbReference type="OrthoDB" id="1130874at2759"/>
    <dbReference type="PhylomeDB" id="E9GMP6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="SSF64268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX79133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="459" mass="51775" checksum="B71B292EAAF60587" modified="2011-04-05" version="1">MALYVFSKSRDVSQQKVDVCIPFAEKEEECTVYVIKVSVGEIWWLVKQRYKNFDLLHQQLVLNHGLRKDLLPAKKIIGNKDPEFIERRRSDLEIYLKKIVQFLEKALPLEVCSFFEFEEYEVYSLVRKLAAELYVNGETKILSGKTISMNPLQLHAVTQKIQLPRSPVEQLNKEQDFAHVLDFLANIESLEIVGNRDFYRNSNLILNNLPFDLSAFKSLKHLCFNGANVSSLICARSLRTSLETLSAHSCGLKSMLEVLVCDSVHKNLEIKVDSPYAWRELVSLDLSENNMTEVSPAAVCLVPKLRRLCLNCNALESVTNLSSLSALEELNLSNNRIRQLPDLHTKLGNVKSLLLAQNRLTNLDGLGKLYGLVTLDVRSNKIADLETIRPVAALPCLEELTLTGNPVTTVLDFRTKVLTMFGNRASEVSLDNEKAMQKELDTVAVLLALSNSAKKLSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GMQ5</accession>
    <name>E9GMQ5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_319754</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732553">
        <property type="protein sequence ID" value="EFX79252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79252">
        <property type="protein sequence ID" value="EFX79252"/>
        <property type="gene ID" value="DAPPUDRAFT_319754"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_319754"/>
    <dbReference type="HOGENOM" id="CLU_641348_0_0_1"/>
    <dbReference type="OMA" id="ATPRHET"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX79252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="428" mass="49145" checksum="FD0A63619CFDA091" modified="2011-04-05" version="1">MAHHRQPKPYDKNETLILFCSPELEEEEEAPAPVAPYSPPALVYAVPEPEQPVVVQQPVVPESPISTIDAVVWDQPEEDQQVLQEFVPVVSQEEEVYVQQPQTPTYVQEEEAPIQEDSLLLSVGQELSQEPEYQEPVRQVEPELVQLPVYQEPVQVPEQTFQVEEQEVPTVEQPVEIQQEQEEEYVEPVQIQQEPVQIQQEVVQIQQEPEQTYQISQEYLPPVQTYKNVEVEPEEASILPEYEPVRIVQQEPEIVQEYVEPVQVVVQEPVVIPEVEQEYVEPVQIAQQPEVEQELVEPVQIPELPTPIQGEEPEQSYQVEQEIEKQEQASSPKYQEPIDQQFNFQQTIENFAKQQTDENLAPVISANKQAGRGRPIRPRPIIFQRTEEDLFQAGFPEVAAPEGDDVPLEEQAAIREAIFELKKESRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9GMX8</accession>
    <name>E9GMX8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS_1_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_319820</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732553">
        <property type="protein sequence ID" value="EFX79171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79171">
        <property type="protein sequence ID" value="EFX79171"/>
        <property type="gene ID" value="DAPPUDRAFT_319820"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_319820"/>
    <dbReference type="HOGENOM" id="CLU_1817727_0_0_1"/>
    <dbReference type="InParanoid" id="E9GMX8"/>
    <dbReference type="OrthoDB" id="628784at2759"/>
    <dbReference type="PhylomeDB" id="E9GMX8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="MFS_1_like" evidence="8">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX79171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="142" mass="15114" checksum="9862E1BEE1E0F09B" modified="2011-04-05" version="1">MTRFFAFRRNPWILIATESLEGFSGFLGIVTGSYYCAAAAPPGMLASLNGIFSAAAFGLGRGIGTSVGSLLISSYGIRSTYLLLSMVAGSVAILYLVVYHLVLKKLEHKRLMLTRSEQGEATAQANGDSSSSLKDDIQVTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GNK8</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX78945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX78945"/>
        <property type="gene ID" value="DAPPUDRAFT_245554"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_245554"/>
    <dbReference type="HOGENOM" id="CLU_1697315_0_0_1"/>
    <dbReference type="InParanoid" id="E9GNK8"/>
    <dbReference type="OrthoDB" id="885842at2759"/>
    <dbReference type="PhylomeDB" id="E9GNK8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX78945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="155" mass="17436" checksum="1B3C1C38693500AD" modified="2011-04-05" version="1">MTLDDLTAKLNKDRFYVKRSTVYTRFQPKLSNSIQGKRHVDTVPIKAENDHHAKHPDELFRTTTIKRLEEVASILGQDKLSSSILTVDQKIIDVATHQFLKHNLDILFVATNAPGSSAYNRVERKMAPLSRELSGSILDHCHFGSHLDSAGKTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQ55</accession>
    <name>E9GQ55_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_246637</name>
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    <organism evidence="3">
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX78215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78215">
        <property type="protein sequence ID" value="EFX78215"/>
        <property type="gene ID" value="DAPPUDRAFT_246637"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_246637"/>
    <dbReference type="HOGENOM" id="CLU_078616_0_0_1"/>
    <dbReference type="OMA" id="SCLPTAC"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237614" evidence="1">
        <location>
            <begin position="25"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX78215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="308" mass="31021" checksum="5F25AE1706B66B81" modified="2011-04-05" version="1">MARTSVLCQLLLVSCCISLVVVNAMPMPSSYDSSESSKERTLENSMEAGGCPTGGCQPVGCPTGGCQPTGCPTGGCQPTGCPTGGCPGNEERNLEIETSQEAEQVEERVSVTSVEEIEIEIEIELESEDPATGCIDASCKNQGAARRPVPCTGPTCTPVAPRVPAPCTGPSCTPVAPRRPVPCTGPTCTPVVPRAPAPCAGPTCTPVAPRAPAPCTGPSCTPVAPTSPAPCTSPSCRPVAPPCPTCSISTEAPVVAKPPRRRTTAPPVAPAEPAAPCPTCKTTTTTTTTTCTTNCAPTTCTTPGCATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9GUZ7</accession>
    <name>E9GUZ7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_106807</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21292972"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="term" value="F:aspartic-type endopeptidase activity"/>
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        <property type="entry name" value="Aspartic_peptidase_AS"/>
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    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="213"/>
            <end position="228"/>
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        <location>
            <begin position="56"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX76577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="376" mass="42736" checksum="5B94898113FE49EF" modified="2011-04-05" version="1">MRRYANRMRKAFHLAYPISGKLDSATSASREQMMMDRFIEGLQPDLQARHKDFPSLEKLIDKAELIALTIEEAETRNEIHAVNAALETTANSEQARVVEALDRLNEKVEKKAATHQEEVELNLELMRKQLAQKQVQFHIPNQSFVTQPGAFKRAAVFCDFHNTEANFWVKEQMVNDRCRTCNKLGHRPHFCPAIRNPRPPHPSGQPVPGDCVVEALVDTGASKSLISDKILVQLKISGIPHSFSRDVSINLFDINDRRLSCIGTIKTNIHVENENTPEFLSQEFVVAQGIMEDCILGLDALYEHKFVIDGFEKQVYRVREPDQFTNRLEPFIMTGGKLTIPPFSACVMESGGMAPNYPLTPHSFSRVVQDYRWVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_249234"/>
    </dbReference>
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    </dbReference>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="129" mass="14766" checksum="3E98F98166A87845" modified="2011-04-05" version="1">MRPGYKADVEFENFCVRFMDEPKIQLPAVGNHPAHPDKYVVQIEVAAQSLQDDYELRVRIFYCPSWPYRGAANPDLAALFRLPKLYQNEPVVVVDRFGGTEAATLCALTTLVQQLSRDQHVDVYIYAKF</sequence>
</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX76186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX76186"/>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_249352"/>
    <dbReference type="HOGENOM" id="CLU_2529739_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GWH5"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX76186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="84" mass="9699" checksum="E0F5878FEC003E8B" modified="2011-04-05" version="1">MRRLADQYATQEKCIVPPRLPCSIYHREVHSTTLCLSTEYFLNGAPLGSAGSSNKSGWMSDQDFVFFMKHFIQHVRLSKENEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GXU1</accession>
    <name>E9GXU1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_107650</name>
    </gene>
    <organism evidence="2">
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        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732581">
        <property type="protein sequence ID" value="EFX74654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74654">
        <property type="protein sequence ID" value="EFX74654"/>
        <property type="gene ID" value="DAPPUDRAFT_108558"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_108558"/>
    <dbReference type="HOGENOM" id="CLU_987857_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="282" mass="31038" checksum="D54952096336D332" modified="2011-04-05" version="1">MGGKVRVQQHPAGGLGDHDVWAFRICLGTIPAPFCRILCDSCRIWPSRPGRPSTAGLDGSQTETAPAAMLFDGRLTRIVHHFYADRCGPLYVSNRRPSLLSCPASYRRDSQPRRPSAAAVDIRHQIPSSHHRRGGDGRSRHVSYPATRRAKSVAPLRFGEDNADAGPLGRPRLGSSPAGGKSSSEMMRSRYFYSFAAIGDDGSSAVQPRRGRLFGRNPAAITRVLAQHQIAQQLQVFMPPTVTQPKQQSAGDYNKTGRYRARSDRRKRPAASSSGRQRQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0Q3</accession>
    <name>E9H0Q3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_307025</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732581">
        <property type="protein sequence ID" value="EFX74709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74709"/>
    <dbReference type="EnsemblMetazoa" id="EFX74709">
        <property type="protein sequence ID" value="EFX74709"/>
        <property type="gene ID" value="DAPPUDRAFT_307025"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307025"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046597_3_1_1"/>
    <dbReference type="InParanoid" id="E9H0Q3"/>
    <dbReference type="OMA" id="NADFYVE"/>
    <dbReference type="OrthoDB" id="1053004at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF52087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="99"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="294" mass="34279" checksum="0D98925204A3C854" modified="2011-04-05" version="1">MEKELITEMRRTSELSEELLIKAKEELGETENIREESLILIKEWIQTQINDYSNLDDLSIRWFLRGCKFDSNKTKVRIETFYSFRSKVTEWYSNRDPLLPELMELLNLGTILPLPGRDDEGRKVIVIRASIHDPYKHKQDDVLKIMNMVVELLCRDDEAISVTGVVCIVDLKGVGMGHAMQMTPSMIRKAVNSWQDVNPIRTKAMHYINTPLNVHVIMNIFKTFMKEKLRRRLHLHRGDVKKVLVSLIPCDILPPEYGGRGLSVESISNEWKERVISNRDWFMNPEKHGPFSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9H1D1</accession>
    <name>E9H1D1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_200025</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732583">
        <property type="protein sequence ID" value="EFX74438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74438"/>
    <dbReference type="EnsemblMetazoa" id="EFX74438">
        <property type="protein sequence ID" value="EFX74438"/>
        <property type="gene ID" value="DAPPUDRAFT_200025"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_200025"/>
    <dbReference type="eggNOG" id="KOG1585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063974_1_0_1"/>
    <dbReference type="InParanoid" id="E9H1D1"/>
    <dbReference type="OMA" id="MHKENGN"/>
    <dbReference type="OrthoDB" id="1540214at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="PTHR13768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX74438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="341" mass="37927" checksum="9E5EB782884933D6" modified="2011-04-05" version="1">MAAAKKSSEGTELVQQAEKHLKTSLLKWKPDYELAADSYNKAATCFKTAKELQKAKDCLYKASDCYKQTKAFFSAAKSLDQAIILLKELQEWKEISNIAHKACQLFQEHGSPDTAALLLDKSAKMIEAHLPEDALVLYRRAMEVVMIEDRPRQASEFATRAGRLLVKLGKYEDAINMLSREMNYHIAGENPAAVGRVLVVVVLLHLVREDVIAAGKAIQEWGGNGQQDELQVAMNLHRAFDSEDAQAAERALADPFIRHMDVEYAKLTRVVPLPKGYSDLENAARPKTNLEDLVDDIPDIDDDDLENEYGGGSRSNNDVEPQAKSTGVKHEEDLEEEGGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9H1Z9</accession>
    <name>E9H1Z9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_252110</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732584">
        <property type="protein sequence ID" value="EFX74257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74257">
        <property type="protein sequence ID" value="EFX74257"/>
        <property type="gene ID" value="DAPPUDRAFT_252110"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_252110"/>
    <dbReference type="HOGENOM" id="CLU_2415536_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX74257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="92" mass="11056" checksum="869621BB5C622CC7" modified="2011-04-05" version="1">MCERPQKSWEWKTTSRSKVAPHSWVAIVKKSGRFNKIPFDNSRWDNSPALKKGYLYWDSINTVKNTLLRYCKIPLVRFWSETPTHDSFPFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9H3M2</accession>
    <name>E9H3M2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiosis-specific nuclear structural protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_325071</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MNS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732589">
        <property type="protein sequence ID" value="EFX73535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73535">
        <property type="protein sequence ID" value="EFX73535"/>
        <property type="gene ID" value="DAPPUDRAFT_325071"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_325071"/>
    <dbReference type="HOGENOM" id="CLU_034848_0_0_1"/>
    <dbReference type="InParanoid" id="E9H3M2"/>
    <dbReference type="OMA" id="YLNKGRA"/>
    <dbReference type="OrthoDB" id="962490at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026504">
        <property type="entry name" value="MNS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19265">
        <property type="entry name" value="PTHR19265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPH" evidence="11">
        <location>
            <begin position="33"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="270"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX73535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="417" mass="51234" checksum="A4DFC480E03E3442" modified="2011-04-05" version="1">MTQKDLEKKFLSRKLSTATAEDLKNEAFRRKIVESSIEIRELESKLKMAYILKERKKQLDEKESIRVMEKVMTLQEREETEKQLKLDHELEIRKLLYEKWKKEKYCQELVKQAEQYRAAKQLELMKERKLDDMYLQEILMAELRRERQEREDRERKKRRLAEELDNCIRLQNQWKAIQKLIEMEEDRLIEECQVQRRRLSHMQQQERKEKADKLAAIRQQLQKALEVEERRRREREELWVEYGCEEREDLETKKAVELEKMTQAQRIKWNEDMTEQLRLLELKKKAMKEEELNERLWMLEQAALEEQAEREAADKRHKDLTQLQKEQAALLEERRQQRKLEFAEKEEERRREEMRQQAEDQAIAEERRRILEQHAPLLIGFMPPGVFRDMAEIRSLPENVQAQFRRHVRIQDDPDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9H4Y8</accession>
    <name>E9H4Y8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_253492</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL732592">
        <property type="protein sequence ID" value="EFX73228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73228">
        <property type="protein sequence ID" value="EFX73228"/>
        <property type="gene ID" value="DAPPUDRAFT_253492"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_253492"/>
    <dbReference type="HOGENOM" id="CLU_2981186_0_0_1"/>
    <dbReference type="InParanoid" id="E9H4Y8"/>
    <dbReference type="PhylomeDB" id="E9H4Y8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="SSF49854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX73228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="58" mass="6387" checksum="9147FF94003CB40A" modified="2011-04-05" version="1">MCTNLTSGGGVVQTPNFPGDYGYNDMSCLVRITAPEYWMIQLNFTTFNLETNSGSVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5I5</accession>
    <name>E9H5I5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_307990</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Andrews J."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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                <person name="Manak J.R."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732595">
        <property type="protein sequence ID" value="EFX72876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72876">
        <property type="protein sequence ID" value="EFX72876"/>
        <property type="gene ID" value="DAPPUDRAFT_110302"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_110302"/>
    <dbReference type="HOGENOM" id="CLU_083426_0_0_1"/>
    <dbReference type="InParanoid" id="E9H5V5"/>
    <dbReference type="OrthoDB" id="1527323at2759"/>
    <dbReference type="PhylomeDB" id="E9H5V5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043227">
        <property type="term" value="C:membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045358">
        <property type="entry name" value="Ty3_capsid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19259">
        <property type="entry name" value="Ty3_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ty3_capsid" evidence="3">
        <location>
            <begin position="45"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX72876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="286" mass="32720" checksum="361F7C7A93322E61" modified="2011-04-05" version="1">MTPTPPTPPTAPIQNPLNQQQGPRTPSPDPNNVPLTKSHLRELYSQDERKSIPVYKGKRGDQLINNWLKDAERVAQSAGWNAKDKIKYFSDRLRGDAADWHSDYIDHAADKEDYDAWEKALISRFLTETEIENLKKQLNELKQMPDQSTQTYVSRLNHLYDIIHGKEIVLDETIAPPEAVVLARSLRKIRGEAKQKILLKGLLPKIVHVVWTRIDVNSSYEDVCEIVYAAETIVNRMEQNVEKSLKATFAGISAHEDEQDVELQRQKNKLSKLEKQLAGLNIEQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6T5</accession>
    <name>E9H6T5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane-bound transcription factor site-2 protease</fullName>
            <ecNumber evidence="3">3.4.24.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endopeptidase S2P</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">EOG090X08FA</name>
        <name evidence="11" type="ORF">DAPPUDRAFT_326128</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TCO</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site 477-DRSRILL-|-CVLTFLCLSFNPLTSLLQWGGA-505. The residues Asn-Pro, 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced.</text>
            <dbReference type="EC" id="3.4.24.85"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.24.85" evidence="3"/>
    <dbReference type="EMBL" id="GL732598">
        <property type="protein sequence ID" value="EFX72568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015330">
        <property type="protein sequence ID" value="SVE84949.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72568"/>
    <dbReference type="EnsemblMetazoa" id="EFX72568">
        <property type="protein sequence ID" value="EFX72568"/>
        <property type="gene ID" value="DAPPUDRAFT_326128"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326128"/>
    <dbReference type="eggNOG" id="KOG2921">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032523_1_0_1"/>
    <dbReference type="OMA" id="CMHYPYD"/>
    <dbReference type="OrthoDB" id="1012405at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051091">
        <property type="term" value="P:positive regulation of DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990440">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PTHR13325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="10">
        <location>
            <begin position="130"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX72568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SVE84949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="484" mass="53650" checksum="83F5EC4B73B9986A" modified="2011-04-05" version="1">MDVTTVFGSVILLHTFFYYLDRYLKGKNSQRYASFLNRFPVQIDFMNVRWTTSMFNKALSSWAMMRLRFLSKWYNIGTVITLLLCIPSLILLGSTALVSFENMMDSKKEEAMLQPVVPGVNLPSYDLPYYLITLLVCTVVHEAGHAIAAVSDQVPLVSVGLILWLIIPAAFVELPTSNVVGLSPWKQLKIYCAGVWHNIVLSAMAFAVLMMLPILLIPLFQSGAGVSVVNLNAYSTDGHHDFQVGDQLTQINDCRVTGVESWRLCLTAVLLESSGFCLDNSYLASSSSSDQLGCCNDSEFSRSHLCFLSSPDLVPKKYHCLRAREVSQLSSAWCSNHKGCSAVNQSCLMPSFHSESVNETDSSRLIIVKRKSADPVLFAGLPNEIYLSVYVSDYVPRIFIGSQFINFIEHLLKYISSFSAGLAVLNVVPCIFMDGHHIVGALSEIVFEGRGSISMKRQTQYALVFLGTSLVVINIAFGVLTLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9H7J7</accession>
    <name>E9H7J7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GBD/FH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_326379</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Thomas W.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="EFX71757.1"/>
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        <property type="protein sequence ID" value="EFX71757"/>
        <property type="gene ID" value="DAPPUDRAFT_111428"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_111428"/>
    <dbReference type="eggNOG" id="KOG3002">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="1811354at2759"/>
    <dbReference type="PhylomeDB" id="E9H951"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="PTHR45877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX71757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="166" mass="19027" checksum="AA5707F6822DD52E" modified="2011-04-05" version="1">MDRGDNRVNIDALLRLFTCPGCGNPANKPPLFQCVKGHVACSQCSVKCRGSCPTCRQRMTTERNFWMEEASTFITFPLQTEGHQAMVKQRNGASFHYVERRAQLVIFVLGASLIELSSRYSEMEDEARNKDKAVAGITTVKWKTFTTRQQQRLLVLLRRFKLQEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9A4</accession>
    <name>E9H9A4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC protein, subfamily ABCG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_347412</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732608">
        <property type="protein sequence ID" value="EFX71588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71588"/>
    <dbReference type="EnsemblMetazoa" id="EFX71588">
        <property type="protein sequence ID" value="EFX71588"/>
        <property type="gene ID" value="DAPPUDRAFT_347412"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_347412"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_57_6_1"/>
    <dbReference type="InParanoid" id="E9H9A4"/>
    <dbReference type="OrthoDB" id="1022017at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="41"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="81"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX71588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="637" mass="71169" checksum="15B615AFA8D4691C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9D9</accession>
    <name>E9H9D9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_28711</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732608">
        <property type="protein sequence ID" value="EFX71671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71671"/>
    <dbReference type="EnsemblMetazoa" id="EFX71671">
        <property type="protein sequence ID" value="EFX71671"/>
        <property type="gene ID" value="DAPPUDRAFT_28711"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_28711"/>
    <dbReference type="HOGENOM" id="CLU_064620_5_2_1"/>
    <dbReference type="InParanoid" id="E9H9D9"/>
    <dbReference type="PhylomeDB" id="E9H9D9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="PTHR45701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="85"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX71671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="85" mass="9754" checksum="986EDC56FEA3DFE3" modified="2011-04-05" version="1" fragment="single">RINSRQLDILHGQMDDVLNVMKENTKRVLDRGHRLHELSERAEALEQQATIFVKSATQVKKKAKFRAAKWTLILAGFVVIFIAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9I4</accession>
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            <fullName evidence="1">DUF4470 domain-containing protein</fullName>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
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        </lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX71645.1"/>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX71645.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="979" mass="112053" checksum="CF37BD5FF84C5F87" modified="2011-04-05" version="1"> </sequence>
</entry>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Robertson H.M."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    <sequence length="172" mass="19331" checksum="8C32E519EC871BEC" modified="2011-04-05" version="1">MKLFVIAAVLAVAAAAPSSYATYEKTYEKDYKYPEITVTSQSDERNLDGSSKWSYAQSDYTTRDETQEQKKFTVTTVDDYGKEYTEEVYGNTNKGSSYWVSPEGEKFTLSWAADEAGFQPKGDHLPVAPVHVYELPVAPVHEYVLPVAPVHEYQLPVAPVHIPFNGKGYKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="HPVIMVL"/>
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    <dbReference type="PhylomeDB" id="E9HAU1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="31"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="284"/>
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        <location>
            <begin position="10"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX71088.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    <sequence length="378" mass="43537" checksum="7DB41C71810C306C" modified="2011-04-05" version="1">MKWWFQGISNATISVDTFLLMGGLLVSFLLLAELDKKKGKFNFGLFYLHRYLRLTPVYAIVLGFIATLIVYMGTGPNWYNIETSAYGCRINWWWHLLYSESNSSMHNSQRYCKCMEQTWYLALDMQLFIVSPLVIYLMWRWKKIGLPLLGFLFIGTIAANFAIFAVFDLMPTVMPTRTMDTIAMGLDADYYYTKPWTRAPPYIVGVWLGWFLYVTKDSQKRTSKIILVIFWTMSSAIILAVIYGLIPYLDETAVPAIDPTISLFYGSLHRTAWAMAVAWIVYACTKGYGGIINRLLSWKGFLPLSRLSYCVYLIHFAYLDVFYASNRKLVYYTFNSQLMTYLGIVVTVFGLAFVVSITVEASFLNIEKLLFASFSPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <name>a divalent metal cation</name>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="210" mass="23479" checksum="AB69777E2BEF1586" modified="2011-04-05" version="1" fragment="single">GERLALKLRFLASGGTLTSLRYSFRVGISTAHSIVRSTSQAIFLALSPSYMKVPSSPVEWESIANEFHNIWNFTHCVGALNGKHIRISFPALCGSQFYNYKNFHSIVLMGLADARYRFIIIDVGASGREGDAAIFSTSTLSAALKSNEMNLPQPCPLPHSVSEFKMPYIIVADEAFPLFRNAMRPYILLYRLSRARRVVENAFGLLVARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
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        </recommendedName>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Kultz D."/>
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                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="101"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="750"/>
            <end position="765"/>
        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
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    <sequence length="1155" mass="126868" checksum="52AFE88B7DC3EAE7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HEF0</accession>
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        <submittedName>
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        </submittedName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Arnold G.J."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_9652"/>
    </dbReference>
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Basu M.K."/>
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                <person name="Dusheyko S."/>
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                <person name="Tsuchiya D."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="EFX66114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="179" mass="20332" checksum="72FFE448292623AE" modified="2011-04-05" version="1">MVLNRPVRDALPAHRHSFAPEWQQKTDVLEKRARRAKEIQIEHYNKTAHSLPPLSIGDHVVIQHPISKCWSTPAVVVEIGPHRDYLLKTPAGRLFRRNHRMLRKRIPVMPGTKSTPTPTPPALIPVKPETTSATKSMPPAPEASPKQAKPRQRGKPKPPTFAVLRRSTRTTKRPDRYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732741">
        <property type="protein sequence ID" value="EFX65539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65539">
        <property type="protein sequence ID" value="EFX65539"/>
        <property type="gene ID" value="DAPPUDRAFT_264553"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_264553"/>
    <dbReference type="HOGENOM" id="CLU_2087220_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX65539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="117" mass="12930" checksum="9865262E2D72F763" modified="2011-04-05" version="1">MTSTEWKVEFKPKTKNLVEPTVLISDPLRSAVREIESSKYEDVIDGRSEWNDYDLPELLSRKDRAMFNRVGLPSTSTVTVIAMETYVVTKAINPVTSVSSQLAGVLICVPPGLVVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9HRW4</accession>
    <name>E9HRW4_DAPPU</name>
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        <submittedName>
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    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732741">
        <property type="protein sequence ID" value="EFX65526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65526">
        <property type="protein sequence ID" value="EFX65526"/>
        <property type="gene ID" value="DAPPUDRAFT_333111"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_333111"/>
    <dbReference type="eggNOG" id="ENOG502QTAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071682_1_0_1"/>
    <dbReference type="InParanoid" id="E9HRW4"/>
    <dbReference type="OMA" id="NERARSC"/>
    <dbReference type="OrthoDB" id="1157817at2759"/>
    <dbReference type="PhylomeDB" id="E9HRW4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="SSF57625"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
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        <location>
            <begin position="97"/>
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        </location>
    </feature>
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        <location>
            <begin position="154"/>
            <end position="210"/>
        </location>
    </feature>
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            <begin position="203"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="241" mass="26224" checksum="DDA5BCE7A93D6DBA" modified="2011-04-05" version="1">MKANIACVLLALAVSSAAAQQLKATQADPCQAKGKMAADVTYCDRYWECIDGAAEQFDCPNGLVFAGRARGLLENCDYPWRGDSCEGKQLANTPVSVGPCDWKYGIFGHESSCIRYWTCWNSTATEQFCIGGLLYNEEKHACDWPEAVEGCQKHPLCKDDANGNVPLGKSCNRYWACQGGYPRLQRCPATLVFDKRSLRCTNPPTEDCEAPPPPPPEDDPNAPAGPAFVEEEEPAAPAPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HTC8</accession>
    <name>E9HTC8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732770">
        <property type="protein sequence ID" value="EFX64994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64994">
        <property type="protein sequence ID" value="EFX64994"/>
        <property type="gene ID" value="DAPPUDRAFT_265386"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_265386"/>
    <dbReference type="HOGENOM" id="CLU_1268035_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HTC8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5003242095" evidence="2">
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            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX64994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="218" mass="24024" checksum="BC947FFB447B87B5" modified="2011-04-05" version="1">MFVSLSSSKMIIRVYLVALFCAVVLGRSAEKDQQNPEDLETNQDTPLISPQSRKTDPKLDVIIAHQPGQPEPHQEIISSFKNFGKDAPEKPELIGEAKSELLQSPPVPVPPNPALSSRSRRFFLPYLSSSYRRPYYRRPYVRGGYYPYYFGGIFGYPYYGAGYGSYGYGDYGGGYYGGYGDYDGGYGDYGGGYGDYGGGFGDYGGGYGDIDIGIDSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HUM7</accession>
    <name>E9HUM7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_266200</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Shaw J.R."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="191" mass="22319" checksum="AACE644B3FF4D4C0" modified="2011-04-05" version="1">MVYYTTTYVTPRCYTETPKYCTGKAEYYTTTFAAPVYYTEKLKYFSAPSNYRTEAPVDYTIYAPGFYSTPYAAPIYTTKAHTTKAPELLLRLLRPSAPKLRIYYIMVKPEMETVYYTEEFKYYSSPNKYQTEAPVYYTTIALECYTTTNNTTPNYYTVAPKCYTSMHNQFAIDMSVVFMVIGHWELIVDLD</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Yamagata H."/>
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                <person name="Koonin E.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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</entry>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Wang M."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX62084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="248" mass="27470" checksum="B0FA3F9E94F45BB9" modified="2011-04-05" version="1">MSSFFQPDQPPWSINHRLTSVAGAFVPLLSSHPKILRVVFWTIRENERPKYCVVASDSKQVRVIKNYSLPTSSSHRLATCAALVKAMNIIQSQSLCFNSFEIFLPGRCAPAFLFPNVRISSAESSVFHKILNLGMSCHLFLFADSLSPGFQLAKVWAALSDVITDSPLKARCLDRAPVASRISDLLYRIWNEEWVSSTKGAATRLFFPTVSSASVLLKLRPSMGVYQLISGHCALNGHQKRVVVITSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2A5</accession>
    <name>E9I2A5_DAPPU</name>
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        <recommendedName>
            <fullName evidence="2">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_271603</name>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734027">
        <property type="protein sequence ID" value="EFX61875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX61875"/>
    <dbReference type="EnsemblMetazoa" id="EFX61875">
        <property type="protein sequence ID" value="EFX61875"/>
        <property type="gene ID" value="DAPPUDRAFT_271603"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_271603"/>
    <dbReference type="eggNOG" id="KOG1856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1679705_0_0_1"/>
    <dbReference type="OrthoDB" id="56990at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX61875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="157" mass="17099" checksum="831BB8FD421BEDD8" modified="2011-04-05" version="1">MSSIPDNFTDWINVRIHLDKDGFGTCSGQAIGVQIRLGNGLTGFLPIKCLSDPEVKTPEERFRPGQTIHCRITRIDVENFSVEATVPVQAPIPLPSAPSTSSRPNSSDGSRSPLPRAHSPISPTPVPAWYQNLVAAQPSIFEGNPVLWETQVILFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9I3X5</accession>
    <name>E9I3X5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_340201</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX61305"/>
        <property type="gene ID" value="DAPPUDRAFT_340201"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_340201"/>
    <dbReference type="HOGENOM" id="CLU_2216410_0_0_1"/>
    <dbReference type="OrthoDB" id="1509316at2759"/>
    <dbReference type="PhylomeDB" id="E9I3X5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="107" mass="12024" checksum="3FA010FB6031D7F9" modified="2011-04-05" version="1" fragment="single">MTKGISTDTSKAISGEFPLEFVDAEFSLKPPKLDGWISRRALLKTDKSIVRSFNAAEESFTKAQLRIMDIAPPLIDLYARLNSLPDSESLKRPVQAALQQWGRAFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9I468</accession>
    <name>E9I468_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_122434</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734923">
        <property type="protein sequence ID" value="EFX61212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61212">
        <property type="protein sequence ID" value="EFX61212"/>
        <property type="gene ID" value="DAPPUDRAFT_122434"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_122434"/>
    <dbReference type="HOGENOM" id="CLU_987855_0_0_1"/>
    <dbReference type="OrthoDB" id="271662at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="282" mass="32492" checksum="28600AD92E852A76" modified="2011-04-05" version="1">MVETLLPCGHLIKVPCSLRNNNNNIGGSVDCVVDGCRRLSTPLATKFDLKAEITKLLTKYLSDESLFKAAESLLRDKSVEDQWRMYQRMYYLCLSAVFKGDLERSYSYSTVNNQPAQVKLQKEWADDLRASHQAVQVKSLEQQATAQVEGCWSVQCLKDALFQWRRLDLLRQCLTMLSVEPQSDTSQTCQHLLKKAQLALQDDGRGSPDKKWTTSQENDVYALLKSVATKMEFDLTRPDVQMIMGHGEHIYRSKQPTKPLHRWECFRADYSYFDLMPFFITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9I4T0</accession>
    <name>E9I4T0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_340824</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
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                <person name="Robertson H.M."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX61001"/>
        <property type="gene ID" value="DAPPUDRAFT_340824"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2514962_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
            <dbReference type="EMBL" id="EFX61001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="85" mass="9828" checksum="1CCC9E4C851496BA" modified="2011-04-05" version="1">MAAVLCVTPIYLKSSYEFQMQPNMDNATSMDEHEQSFWYSEKMRKRQIKLEKQCAIDLQIRNLNRNITAASRNLSPGDSKIVSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9I5T0</accession>
    <name>E9I5T0_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_123435</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL735859">
        <property type="protein sequence ID" value="EFX60650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60650">
        <property type="protein sequence ID" value="EFX60650"/>
        <property type="gene ID" value="DAPPUDRAFT_123435"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_123435"/>
    <dbReference type="HOGENOM" id="CLU_1134562_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX60650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="245" mass="27163" checksum="90F61DD6C3EE984B" modified="2011-04-05" version="1">MKTKSQFSCMYLVPPEIYKRLLDTADAREKVKVQELNAPEVGNEIGAFPSLPNTPDYDANTSQDNNDGDDGDDYGGDDDGDGGDDGGRYDPPSRRPSTSSSSSRQSSHGSTTDTASETERHLQNNMNSQNAVLSNRPQTFLQQFSDSEDDNLFSSNFAKHPELLRHSLDPVNTTQPSTSTSSRPLIDSSQHQTSLENSLGPELERIMNDMIKIRSVALEQQRILQDISKKAKKKKILLVMVNKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9I5T8</accession>
    <name>E9I5T8_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_342204</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX60642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX60642">
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        <property type="gene ID" value="DAPPUDRAFT_342204"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_342204"/>
    <dbReference type="eggNOG" id="KOG3025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9I5T8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000276">
        <property type="term" value="C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPASEC"/>
    </dbReference>
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        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX60642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="60" mass="6142" checksum="2914981E4AD87B7B" modified="2011-04-05" version="1">MVQARKLIGAGSALIALAGVGAGIGIVFGALIQRARRNPQMAKRLMGYALLGFALCESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9I6N7</accession>
    <name>E9I6N7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_343309</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL736596">
        <property type="protein sequence ID" value="EFX60343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60343">
        <property type="protein sequence ID" value="EFX60343"/>
        <property type="gene ID" value="DAPPUDRAFT_343309"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_343309"/>
    <dbReference type="HOGENOM" id="CLU_2270399_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX60343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="103" mass="11646" checksum="905ED3913F52970B" modified="2011-04-05" version="1" fragment="single">MELEDLVDKYRSSTRLTKGLLIIFSGLLPALYLWVNEAESLEFRRNQVETEVAQERAKFEAARQKTAELPALLSKLTSIEEDLKKAKLILPDTIAVDSILGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9I7P5</accession>
    <name>E9I7P5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_280017</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL737403">
        <property type="protein sequence ID" value="EFX59985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX59985">
        <property type="protein sequence ID" value="EFX59985"/>
        <property type="gene ID" value="DAPPUDRAFT_280017"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_280017"/>
    <dbReference type="HOGENOM" id="CLU_856785_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX59985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="325" mass="34033" checksum="8B54E99EA54973FF" modified="2011-04-05" version="1" fragment="single">MVPLPNEDTAKWGIGKXKRPEKDTLEKTLADYNKVATEQDNVQLKHMETVFEQSRKLLNPAFSGGGPRMAGSTKHDGSVKAEIDFAERIRAFILQAFKDNVAKWGEVFDIVGGALRNLASALIQGVAGIADALMGQGGLMAAIGQLAGGVLEGVGGLAQTLVSVVGSALAEVTFGISAIVAKPLNAMISVFTEGGAAALSTFGKFGDTMAPVIELMTYLGDVLYGVQNALGDSFLIAASIMREAVTRIGRSLELLAQKGLFETLATGFATVLEILSKFVAVAAVFFSPSTFNASPIALFLAVVSSVADGLLAVNDMIVALMRDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9FQS7</accession>
    <name>E9FQS7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_299880</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX90321">
        <property type="protein sequence ID" value="EFX90321"/>
        <property type="gene ID" value="DAPPUDRAFT_299880"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299880"/>
    <dbReference type="HOGENOM" id="CLU_816999_0_0_1"/>
    <dbReference type="OrthoDB" id="1709618at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236288" evidence="2">
        <location>
            <begin position="22"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX90321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="340" mass="37449" checksum="BFF6C955588977A5" modified="2011-04-05" version="1">MLRRLLPIILLLHYFQGLGYCSGPSALQDVDPTNPSDAASKADHLSSTDGPEKLNNNDRAQQKGDEKPASMDNRRQRRHIGSIAAFRGLPGPFNKFNPAEWPLSSAGWDWKKVMTPGADFVDYGEGLDEDVIKDKRYPDVIQAAIQRNGVRPNPVLMRNNPIISGKSSNKNFEILPPPHNEARARAVSRLLRLLSEARANSAAGANSISKKFLGALARNNALPASGPKAILPFVQYKGSTAIPLPGKRTLINSGAPRILDNRSEATDTDAHLEFSNQVEEFPMEDVYSDDVMLGMGEDEDQTDDYSELVTSNKRNIASLAAKGGWARPSRTYNRMPHYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRT8</accession>
    <name>E9FRT8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipocln_cytosolic_FA-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_299805</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX89905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89905">
        <property type="protein sequence ID" value="EFX89905"/>
        <property type="gene ID" value="DAPPUDRAFT_299805"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299805"/>
    <dbReference type="eggNOG" id="KOG4824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068449_2_0_1"/>
    <dbReference type="InParanoid" id="E9FRT8"/>
    <dbReference type="OMA" id="ACDVMVM"/>
    <dbReference type="OrthoDB" id="1631943at2759"/>
    <dbReference type="PhylomeDB" id="E9FRT8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031409">
        <property type="term" value="F:pigment binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
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        <property type="entry name" value="SSF50814"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013437379" description="Lipocln_cytosolic_FA-bd_dom domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX89905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="193" mass="21359" checksum="51366EB8F430606F" modified="2011-04-05" version="1">MANNLIQVLLLATCCIAGLNANVLVRSTRGACPTFTTKPDFDYVQYAGVWFEIEKIPVVFEEGMTCIRAIYDEIAPNTVSVVNTAVLNGNTTAIYGSAYQPYPETQPGYLIVQFPGRPDGDYFVLDTDYVTYTAVYDCVSVGAFKLEYAWLMGRTNSLTPEQLATARAAYTQFGIDISTFEATFHDENCVYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSQ5</accession>
    <name>E9FSQ5_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89782">
        <property type="protein sequence ID" value="EFX89782"/>
        <property type="gene ID" value="DAPPUDRAFT_232924"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_232924"/>
    <dbReference type="HOGENOM" id="CLU_1645431_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX89782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="161" mass="18703" checksum="03E8EA2F5C961F8F" modified="2011-04-05" version="1">MVPKYYTTKSPKCYMTTLTYFAAPPAEPRLTKSLEYYTKTYVVRAYYNTKAPVYYTTTFYYTTTYASSNYYTEAPKYCIEKLEPKSRTASKTYGAPVYYTEEPNELWRHAAVGCCIVHGWVNLGCTYVSCVWWISSDSSDRTVEYVAALLHNVNIRNTTYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89585"/>
    <dbReference type="EnsemblMetazoa" id="EFX89585">
        <property type="protein sequence ID" value="EFX89585"/>
        <property type="gene ID" value="DAPPUDRAFT_40148"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_40148"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9FTT8"/>
    <dbReference type="OMA" id="HEALISC"/>
    <dbReference type="OrthoDB" id="619766at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone methyltransferase activity (H3-K4 specific)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX89585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="139" mass="15123" checksum="DD71C802B581E01B" modified="2011-04-05" version="1">MQSTTLFCSECLGTSEKNSQGEHEALISCSECGSSVHPSCLKRAGTSTLKEEDDWLCSECKSCNICGERAEIDPLLICNVCEQGFHAHCVDPPVEKRPKTWSCSNCAARRKSKQGTKSSDVSLKKGRKRVDSSSSEEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9FW22</accession>
    <name>E9FW22_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_233897</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88998">
        <property type="protein sequence ID" value="EFX88998"/>
        <property type="gene ID" value="DAPPUDRAFT_233897"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_233897"/>
    <dbReference type="HOGENOM" id="CLU_1086884_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX88998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="256" mass="28465" checksum="80B3F5218108F648" modified="2011-04-05" version="1">MKCFVHSVIGLPPQTICKLICASDIFAVDLSDEISALKRGDDEVTGEIAESFSRLPLIHSLAALNAHTCIINYGLRFPWLLILEYQEKKYDVYYERSSMYLCHPNFDDPYATAQWIALVHIDHKKERGLFVTATTQFRVLYQYSRMPTTNKIKYESGNGGAEALGDGGIHSIDDASSLRISIMESIVMDERAPFELITISERRIGYLENGSDPLPVSLPYLPPSRPAQEFWLKDVGSLLPLPSAAAAAPVAALRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9FWQ0</accession>
    <name>E9FWQ0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_234478</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX87931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87931">
        <property type="protein sequence ID" value="EFX87931"/>
        <property type="gene ID" value="DAPPUDRAFT_234478"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_234478"/>
    <dbReference type="eggNOG" id="ENOG502QRD5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069223_1_0_1"/>
    <dbReference type="InParanoid" id="E9FWQ0"/>
    <dbReference type="OrthoDB" id="1540267at2759"/>
    <dbReference type="PhylomeDB" id="E9FWQ0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="PTHR32026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13383">
        <property type="entry name" value="Methyltransf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltranfer_dom" evidence="2">
        <location>
            <begin position="118"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX87931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="328" mass="37761" checksum="B300E2F89832DEA2" modified="2011-04-05" version="1">MARECQGSKEVMQFIRWLARIATSLATMKTTLVIAMSAISTIGIVTILSLGFPTAIPVYQCLQTTSYFPSSSPLLVDWSLVDVNTMDSKQIMDYFQWSNASSCRLAQYFGGVTFLFGIDGQKAVCMDPEIMPLAGKCLVYSFGINNDWSFEEMIERYGCQVYAFDPSLNLTDHDRNGTNIHYFKLGLSYRQEHFQDGWQVQTLSSIYDKLRSEKRHASDRIIDYLKIDIEEDEWTALVDILDSGMLGKVRQLAIEIHLPLEGNISSYRRLVNLLRSMEEQHGMVRFDSKINAYSEGRLKPLLGMMGYASHEIAWHNRQLRRRERYYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9FWY1</accession>
    <name>E9FWY1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_311453</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase VIII family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88356"/>
    <dbReference type="EnsemblMetazoa" id="EFX88356">
        <property type="protein sequence ID" value="EFX88356"/>
        <property type="gene ID" value="DAPPUDRAFT_311453"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_311453"/>
    <dbReference type="HOGENOM" id="CLU_2760383_0_0_1"/>
    <dbReference type="InParanoid" id="E9FWY1"/>
    <dbReference type="OrthoDB" id="1632471at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005751">
        <property type="term" value="C:mitochondrial respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003205">
        <property type="entry name" value="Cyt_c_oxidase_su8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02285">
        <property type="entry name" value="COX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX88356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="70" mass="7306" checksum="CAD9772667BB5FC2" modified="2011-04-05" version="1">MLARRTLALTKSLVGSNGFQLRTSTISGPARVKVSSGEMAVLGLVITLGVSFFPAWVLVNIPAYRGGAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXT8</accession>
    <name>E9FXT8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_305718</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 5">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
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    </comment>
    <comment type="pathway">
        <text evidence="3 5">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="4 5">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="481" mass="55780" checksum="1924F2A83EAB6B77" modified="2011-04-05" version="1">MEPDSDEQQRMELLTTLENFRWLGSKTPCFPVNGNKVRVLSDPEDFYKTLIEKTSQASQRVTFASLYLGTGNHENELVKTIESTLKKNSGSSLKVRILLDATRGSRGAQINSRTMLLPLVQSYSQQCSVHFYHTPALRGLLKKILPERWNEIIGLQHMKIYIFDDSLLISGANLSHDYFTNRQDRYIIMEDCKDLVDFFDQLVETVCQFSFHLSENNCLNLNSAFPHHPFESNRLEFTEEAKRRINNLFEKQIKANVSSSIFQWPNPSAYDTWIFPFIQMGQLNIYMDNILTREILENVPANAELCLATGYFNLTQDYMDSLLEASQPNVHILMAHPLANGFLGAKGFAGGIPSGYTLLAYQFYRRVVDRALEARIRLWEYQRQNWTFHAKGLWISFNRGDPRPSFTLVGSPNFGYRSVYRDLEAQLAVVTINPTLRDQLHRERKNLFQQADLVNGTTFNHPDRKIPLWVRFVIKVFRRFF</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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        </citation>
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    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="1 2" key="1">
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                <person name="Carmel L."/>
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                <person name="Wang M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="71" mass="8139" checksum="8F53E7048BD17D5B" modified="2011-04-05" version="1">MNRRVVWPRRQDPDLIPPKVESGRCDIIQDAVVMEFKDQQSMPWNQVPTTSSSSPSPIMCLHIVVTKQCVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9G2Q0</accession>
    <name>E9G2Q0_DAPPU</name>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Choi J.H."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Tu H."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_788145_0_0_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX86087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="352" mass="40043" checksum="DC21558C79C9340E" modified="2011-04-05" version="1">MQSSDSIPAKNSWAEGRACLLDYTEHLSYVHLWPDGFANAMGKSDAWENKTTIFFGWPILVVPKTEDDDGGWAVMRKAEATSEFIMTGLELLGNGYRNHQPAPPSVNCRKKSQVPPTTSTQKRGQQIGIARDLHHHQHTDLGMVSCKTRTRQAEDKQFDPLPVVCDWFRHCRRRRPPAVTSPPHTAPTLSDEASQHYVYTYIQFWEDENPPAPSPFRYEQIHLLFRSGPFSLPVVSEDLLTPGNAQFPPSCYCSSIYVCLMRRIESLKEEDKKRESALHYSGSNERNREYNLIGCTMALWGPRRKTSPGTEFDCTHWRLRSDPMMNGVKISIDNGQLLRATDDDGFLLGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3J5</accession>
    <name>E9G3J5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_237294</name>
        <name evidence="3" type="ORF">DAPPUDRAFT_307729</name>
        <name evidence="5" type="ORF">DAPPUDRAFT_313586</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733130">
        <property type="protein sequence ID" value="EFX63272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63272">
        <property type="protein sequence ID" value="EFX63272"/>
        <property type="gene ID" value="DAPPUDRAFT_307729"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85787">
        <property type="protein sequence ID" value="EFX85787"/>
        <property type="gene ID" value="DAPPUDRAFT_237294"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85974">
        <property type="protein sequence ID" value="EFX85974"/>
        <property type="gene ID" value="DAPPUDRAFT_313586"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_237294"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307729"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_313586"/>
    <dbReference type="eggNOG" id="ENOG502RZ0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092569_0_0_1"/>
    <dbReference type="OrthoDB" id="407147at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008592">
        <property type="term" value="P:regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="SSF57501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010831017" description="Spaetzle domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="2">
        <location>
            <begin position="132"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX63272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX85787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX85974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="233" mass="26090" checksum="D81A0A5D710BE8D6" modified="2011-04-05" version="1">MKIVVLCISAILLVGVFADPEAAAEPQQYPKPAYPAAYGQKYNNYCNPRKAPTCAKTGTETFCLKDTEYPEKEVKYAIDYDPLVLKKYADVADQSADNLVDGLTSLAEAHFDYSNYKGKFFEKGHWSGDEGYICPSDVVYARPLRAVNVDGEWRVIVQENAWPGYTQTQRVETCLFPGASCRTLAPCYGSKCLQKYVYQRMLSFDPCDPQKGIFVDIYKLPSACSCHIPGKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3V4</accession>
    <name>E9G3V4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_45422</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85922"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_45422"/>
    <dbReference type="eggNOG" id="KOG2621">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_3_0_1"/>
    <dbReference type="InParanoid" id="E9G3V4"/>
    <dbReference type="OMA" id="MVISPNE"/>
    <dbReference type="OrthoDB" id="1062075at2759"/>
    <dbReference type="PhylomeDB" id="E9G3V4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240602" description="PHB domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="25"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX85922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="263" mass="29142" checksum="168C2EBD60784341" modified="2011-04-05" version="1" fragment="single">GICAFILTLFSFLLILATFPLSLCFSVKVVQEYERAVIFRLGRLLKGGARGPGIFFIVPCIDTYRKVDLRTVSFDVPPQEILSRDSVTVAVDAVVYYRVQNPTIAVSNVENFSHSTRLLAATTLRNVLGTKNLAEILSERETISHTMQSSLDEATDPWGVKVERVEIKDVRLPVQLQRAMAAEAEAAREARAKVIAAEGEQKASRALRDAAEVIAESPAALQLRYLQTLNTISAEKNSTIIFPLPIDILKHFIKPGKVDKYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9G4T3</accession>
    <name>E9G4T3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyisobutyryl-CoA hydrolase, mitochondrial</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_46163</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85502"/>
    <dbReference type="EnsemblMetazoa" id="EFX85502">
        <property type="protein sequence ID" value="EFX85502"/>
        <property type="gene ID" value="DAPPUDRAFT_46163"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_46163"/>
    <dbReference type="eggNOG" id="KOG1684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_22_1_1"/>
    <dbReference type="InParanoid" id="E9G4T3"/>
    <dbReference type="OMA" id="GKPYIAF"/>
    <dbReference type="OrthoDB" id="1369862at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:valine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="PTHR43176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ECH_2" evidence="9">
        <location>
            <begin position="58"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX85502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="379" mass="42164" checksum="25C34672F4FADFD3" modified="2011-04-05" version="1">MLGHAGKLCFFRSVAKVSFDGRCNITPKRMSTMMRHFSANPSSNQDEVILETEGNKCLITLNRPKALNALNLNMIRKITPALKQWENEEKVLIIIHGTGGKAFCAGGDVRSIIETRNQPTSTLSCDFFREEYQLNYLISTLQTPYIALIDGITMGGGVGLSVHGYYRVSSDKTLFAMPETAIGFVPEVGGTYFLPRLTGKLGLFLALTGYRLKGADVYHAGISTHAVNSQENSEIEGCLAKFTKAATFLEKPFSLEPHMPLINDCFSAASVEEIVAQLKASNDPFAQETLTTIRKMSPFALKITKRALDEGSEQTLAECLQMEYRLSQRFVADHDFPEGVRALLIDKDQKPQWKPSSLEECTPEKIQSYFEPVKDELQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9G4W5</accession>
    <name>E9G4W5_DAPPU</name>
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        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_237975</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85370">
        <property type="protein sequence ID" value="EFX85370"/>
        <property type="gene ID" value="DAPPUDRAFT_237975"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_237975"/>
    <dbReference type="eggNOG" id="ENOG502QVEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007156_0_0_1"/>
    <dbReference type="InParanoid" id="E9G4W5"/>
    <dbReference type="OrthoDB" id="550249at2759"/>
    <dbReference type="PhylomeDB" id="E9G4W5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="801"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX85370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="842" mass="96954" checksum="48C33A4B37CD02EA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9G5G2</accession>
    <name>E9G5G2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_313849</name>
    </gene>
    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
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                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85199">
        <property type="protein sequence ID" value="EFX85199"/>
        <property type="gene ID" value="DAPPUDRAFT_313849"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_313849"/>
    <dbReference type="eggNOG" id="ENOG502T2KN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129481_0_0_1"/>
    <dbReference type="InParanoid" id="E9G5G2"/>
    <dbReference type="OrthoDB" id="1524391at2759"/>
    <dbReference type="PhylomeDB" id="E9G5G2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031720">
        <property type="entry name" value="DUF4728"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15860">
        <property type="entry name" value="DUF4728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX85199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="178" mass="19971" checksum="9A265BD5667A6EBA" modified="2011-04-05" version="1">MKIHEFDECCCGCSLRTGTKIIGFISMLIEIGVFVLAIIKMKFNFNIDNEIEEMLTNDSIDPIISLGVGMAAAACVVIAAWKDRRPMLLVPWLVLEGSTLPVMIGNSIYFGTLLTIRMGTSTGMAFLAVSLLATAICFYFWLVVFNYYFEMKTSNDMIPDEKSPLMDYEYVDKNLIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9G619</accession>
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        <recommendedName>
            <fullName evidence="2">Macro domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX85072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85072"/>
    <dbReference type="EnsemblMetazoa" id="EFX85072">
        <property type="protein sequence ID" value="EFX85072"/>
        <property type="gene ID" value="DAPPUDRAFT_230572"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230572"/>
    <dbReference type="eggNOG" id="KOG2633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_3_0_1"/>
    <dbReference type="InParanoid" id="E9G619"/>
    <dbReference type="OMA" id="DSAERDW"/>
    <dbReference type="OrthoDB" id="937161at2759"/>
    <dbReference type="PhylomeDB" id="E9G619"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140293">
        <property type="term" value="F:ADP-ribosylglutamate hydrolase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
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    </dbReference>
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        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0042278">
        <property type="term" value="P:purine nucleoside metabolic process"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
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        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="75"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX85072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="257" mass="28279" checksum="95C12D2164ADBFF5" modified="2011-04-05" version="1">MYFIQTIGKYLIPKEYFNKSISIMAKEFKNWQEAKAKYLEESTGTQNQQCVSVKEIPTWEETSKEIHTSTSDGNNTDSKPNLSINSKVSLWKGDITQLEVGAIVNAANSRLAGGGGVDGAIHKAAGPYLLEECQSIKGGCQTGDAKLTGGYKLPAKYVIQTVGPMNRDSSLLSECYSNSLKLANDKKLKTIVFPCISTGVFGYPNRDAAVVALSTTKKFLESDESTLERVIFCVFLEEDLKVYKELLPKHFPVKAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6Z9</accession>
    <name>E9G6Z9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_314642</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84372"/>
    <dbReference type="EnsemblMetazoa" id="EFX84372">
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        <property type="gene ID" value="DAPPUDRAFT_314642"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_314642"/>
    <dbReference type="eggNOG" id="KOG3909">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1397634_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:tRNA-guanine transglycosylation"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="86"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="195" mass="21515" checksum="4A54CC753F14F15C" modified="2011-04-05" version="1">MKFAVYLVAESSARLGSLTEFARIPEAVFETPLLLLHTRGASVPHLSYDLLQMVSTGHYMLQMPLVTLVDHTKNVKAFGKGIAEFAGIDIFDATFPWLVAERGGALVFPNSLSKENVPVTETLPSVKAPAVVATDQKVAKFADDNSSDEAVDRVYEINLKDKIYFSDTRPLLEGCSCYSCRKYSRSSRSPFDRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7T1</accession>
    <name>E9G7T1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_99703</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
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                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84604">
        <property type="protein sequence ID" value="EFX84604"/>
        <property type="gene ID" value="DAPPUDRAFT_99703"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_99703"/>
    <dbReference type="HOGENOM" id="CLU_1504945_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX84604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="179" mass="19737" checksum="6EA3EB448DDD716A" modified="2011-04-05" version="1">MEDSELNDTNALVGAVGGAENELQNSESSEGSSSDFYVYVRMYMMSSCNKRTHHVICMCELRREKVLVFCQSPTSIDVIEEFLLAEHTKNETNWTSSAITDVRSFTSIATYNHFAFGTPTAILIMSVLNFCVGAVGGAENELQNSESSEGSSSDDFGSQGHQSLNTDILRELMSEFLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7U2</accession>
    <name>E9G7U2_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_238930</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84600">
        <property type="protein sequence ID" value="EFX84600"/>
        <property type="gene ID" value="DAPPUDRAFT_238930"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238930"/>
    <dbReference type="HOGENOM" id="CLU_1483432_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="182" mass="20957" checksum="3A214590C1F8209B" modified="2011-04-05" version="1">MTPHTPASAIQLENKKRNQRRKRKQKLEEKKQKLEEKRKQEKKNREKAREEDNRSEEDDDEFKVDIHWVNVEHIKIEVCYHQTALSSFNQPSDPTQDGVTGKKNSTIWKVFQQVSVDPGGGKFCYAASPSLFADSSPDENMSDSKKARYKDYTSLPDHFELSKTPSSLSYKGGPQQGTKSCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9G893</accession>
    <name>E9G893_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_99779</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX83936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83936">
        <property type="protein sequence ID" value="EFX83936"/>
        <property type="gene ID" value="DAPPUDRAFT_99779"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_99779"/>
    <dbReference type="eggNOG" id="ENOG502RYCJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042524_0_0_1"/>
    <dbReference type="InParanoid" id="E9G893"/>
    <dbReference type="OMA" id="KGCFDWW"/>
    <dbReference type="OrthoDB" id="757665at2759"/>
    <dbReference type="PhylomeDB" id="E9G893"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236741" evidence="2">
        <location>
            <begin position="18"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX83936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="337" mass="36208" checksum="7857310D50C46E68" modified="2011-04-05" version="1">MTILLVAALLLPAAILATPPSLAAGSLGNYNIISGSITTSGISSGAVMATQFHVVHSSSVNGVGIFAGVPYGCALGLIAESLNCMLYPNLIVMANLYGRVATYDLYNNIDTVDGLVNDKVFIFHGTEDSVVNPGSADNVETFYNKYNSLVYKKNDIAAQHCMPTDNYGGACDQLNSDSYINNCGYNGAFEMSNYLYGGGLRRPSGNEAVLSNLLEFDQAEFFQISNPATSSMDDIGYVYVPTRCANGVACKLHVAFHGCQQGRVAIGNVYAVHAGYLEVAELNDIIILFPQAISKAISNPQGCWDWWGYTNILYDTNNGNQIIAVKRMVDKMTGFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9G968</accession>
    <name>E9G968_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfotransfer_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_301363</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84145">
        <property type="protein sequence ID" value="EFX84145"/>
        <property type="gene ID" value="DAPPUDRAFT_301363"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301363"/>
    <dbReference type="eggNOG" id="KOG1584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027239_1_1_1"/>
    <dbReference type="InParanoid" id="E9G968"/>
    <dbReference type="OMA" id="NICTCTW"/>
    <dbReference type="OrthoDB" id="780670at2759"/>
    <dbReference type="PhylomeDB" id="E9G968"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051923">
        <property type="term" value="P:sulfation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransfer_1" evidence="1">
        <location>
            <begin position="69"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="378" mass="44805" checksum="DB78CA186CDDD088" modified="2011-04-05" version="1">MPSNESSGRHPLNVKFVPIPETLPEDGQFRQDFPSYTDGLVEASPGGYITTTQVFAENAENIFNLKPRPDDVFVLTFPKSGTTWTQDLVWLLMNNCDFERSKIPLVIRSPFLEMNYYVPKALQEKYERDAIISKMRLPAFLVDLMYRFNIMDIVRPAVMKIMNLVVGEAVRDLNQLERMKSPRVFKTHLPLYLLHPELLETSKVVYVARNPKDVIVSYFHFHKLMNQHKFTGDLESFADYFMKDRLYSSPYFPHLLDAWTKRHHPNLLFIFYEDLKRDLRGEIQKIGRFLGRYPNEYQLNKMVEHLRIDKFATNKSVNFEHYRWLNFMSPDGRFIRNGKTGDWKNHFSPELNARIEEWMKENLKDTDLNFITELEQQD</sequence>
</entry>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="337"/>
        </location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="459" mass="49371" checksum="DF192F4399CAA81E" modified="2011-04-05" version="1">MSSESKENPTIAINAHGADASDLFDPWCDPKNPRIVQFQDISAAAFKIKSGIMMTPCTRSHLSSMTETQIFFKKDFLQYTGSFKERGARYTLLMLPEVNQKQGVCTASAGNHALALSYHGQELGIPVTVVMPIVAPIMKVQSCRQFGANIIIHGRDIGESREFAMRLAKEKTLTYINGYDHPHIIAGQGTMGLEIVEQVKNIDAVVVPVGGGGLIAGVALAVKSLYPHIQVIGVESERCASFSSALKIGQPIYTKAESTLADGLAVPRVGINSLATAAPLVDKCVVVKEEYIAMAILRLVEIEKAVVEGAGACGLAAILAGLLPELKGKRVVIPLCGGNIDTTVLGRCLERGLAVDGRLVKFSVTVSDRPGGIAELCRLMANLGVSIKDILHERAWLKSDIFSVEVRVMCETRDVEHAVELERVLKEHYNNVHFGKMADALGGSGLAAEEIMDSRSPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9GCL7</accession>
    <name>E9GCL7_DAPPU</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Daphnia pulex</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX82844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_101181"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="696"/>
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        </location>
    </feature>
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        <location>
            <begin position="757"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX82844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="933" mass="101017" checksum="B23B95F5A01E3488" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDK9</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2">
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        <name type="common">Water flea</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX82100"/>
        <property type="gene ID" value="DAPPUDRAFT_241168"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241168"/>
    <dbReference type="HOGENOM" id="CLU_2429276_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX82100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="91" mass="10150" checksum="8AA5F3FDCFCDEB51" modified="2011-04-05" version="1">MEPGSNLELPSKNDVGMTSLNPTIMMPPYLMPPPHMLPPPTIMRPLCTIPPPHMMKHPPPLYVGRYGLPPTFQGNGLVGMPMLHSRNNYHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9GE00</accession>
    <name>E9GE00_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_316783</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82181">
        <property type="protein sequence ID" value="EFX82181"/>
        <property type="gene ID" value="DAPPUDRAFT_316783"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_316783"/>
    <dbReference type="HOGENOM" id="CLU_095093_0_0_1"/>
    <dbReference type="InParanoid" id="E9GE00"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="PhylomeDB" id="E9GE00"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX82181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="193" mass="21935" checksum="A67EA420F409002F" modified="2011-04-05" version="1">MRGPRNYYLELKMNGHDVRLKLDSGCDKPMISKAVWTQMKEPKLLIIKGIARTSATGVVPVKGVFLARMSFAGINFRCPVLVSDNDNTRNLIGRRAFPFLMDFNWNKFIRDGTVSMVSSDLTMTDDDKKQEMMANTVKWLTLPFYVNVLINGKDYEMKLDTGSTCSMGPSEMGRIGETQTDYGQTHESHEYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9GE89</accession>
    <name>E9GE89_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PBPe domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_241433</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82353">
        <property type="protein sequence ID" value="EFX82353"/>
        <property type="gene ID" value="DAPPUDRAFT_241433"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241433"/>
    <dbReference type="HOGENOM" id="CLU_007257_4_1_1"/>
    <dbReference type="InParanoid" id="E9GE89"/>
    <dbReference type="OrthoDB" id="218754at33208"/>
    <dbReference type="PhylomeDB" id="E9GE89"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236938" description="PBPe domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="4">
        <location>
            <begin position="105"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX82353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="278" mass="31763" checksum="1A9E765357E62390" modified="2011-04-05" version="1">MSFLPFLTFFTWFIISFHSSSPTPNPLSGQHLRVIWAKMIGHGYLTKNNDLSQQSELLVHDTIATFQYNSVVDFTLPWVYDHFAFLIPVPDETVNINAVVKPFQWPVWLGLGVSIACVIAVLNLIQRYLEYRSGFEMNFKTSNKTQPENLANGNQLRFKKWQTEKQYLYVFGNLLSQGGLFPSKRLPYRLVAGVWTLAAFFFVQSYTSTLFTYVVTPINHPLINSIYDANVYLKDVIRNDFKKTGTCNLQLAKEGFIAVMSSLVLPKNSPYTQTISQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GF40</accession>
    <name>E9GF40_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_241795</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732541">
        <property type="protein sequence ID" value="EFX81966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81966">
        <property type="protein sequence ID" value="EFX81966"/>
        <property type="gene ID" value="DAPPUDRAFT_241795"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241795"/>
    <dbReference type="HOGENOM" id="CLU_2944025_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX81966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="60" mass="6741" checksum="176DBC5A663451AA" modified="2011-04-05" version="1">MVWLQPAVEWCCEPHGEVWASSFCSPLCTWTCCCQMNCPITCPHRPVPSIHHIGLTNLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9GG52</accession>
    <name>E9GG52_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_242223</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732543">
        <property type="protein sequence ID" value="EFX81339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81339">
        <property type="protein sequence ID" value="EFX81339"/>
        <property type="gene ID" value="DAPPUDRAFT_242223"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_242223"/>
    <dbReference type="eggNOG" id="ENOG502SX9R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1355876_0_0_1"/>
    <dbReference type="OrthoDB" id="1928998at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241190" evidence="2">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX81339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="181" mass="18492" checksum="4D8C3D9FDB3613A3" modified="2011-04-05" version="1">MNTFKTVIICAMLGVSASCSSSYQPAGSQGSQTAETASDFHGGVTGGGGQSSSYVNQPVVPNSPSGFGAEQQRPAESAGPLFGAEKARPVIAAAAAAAATAKTTQYICSCITINPVATVTPHQVPTGDSFVQAAAQQQTFASQQEQQQQQQQQQSSVGPASSQSVPVQQQQQSAGDNRGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9GLW8</accession>
    <name>E9GLW8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_52273</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732551">
        <property type="protein sequence ID" value="EFX79587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79587"/>
    <dbReference type="EnsemblMetazoa" id="EFX79587">
        <property type="protein sequence ID" value="EFX79587"/>
        <property type="gene ID" value="DAPPUDRAFT_52273"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_52273"/>
    <dbReference type="eggNOG" id="KOG0669">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="E9GLW8"/>
    <dbReference type="OMA" id="YLAPPCQ"/>
    <dbReference type="OrthoDB" id="925637at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX79587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="386" mass="43967" checksum="651C2E4A3A809C39" modified="2011-04-05" version="1">MSTITSKDREKLLEELKFPFCDDVNKYEILAKIGQGTFGEVFKARHKENKKIVAIKKVLVINEKEGFPVTALRENHILKLLNLGSKGDPQCPNVVNLIEVCRTKVTQPNNCKPTLFLVLDFCEHDLAGLLSNANVRFSLGEIKEVMQQLFEGISFIHRKKILHRDMKPANILITKSGVLKLADFGLARVFSLHENNQSNRYTNPVVTLWYRPPELLLGERNYGPRVDMWGAGCIMAEMWTRNPIMQGNTEQHQVTLICQLCGSFDPAIWPDVGKLELYNKMKLPKGQKRKLKERLNPCVKDPYACDLLDKLLTLDPSKRADADAARNHTFFRSDPLPCNLSTMLSQHHHNMFAFLTPPRQAGRPHPALPQPKPHLSPDSSFPDRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9GMI9</accession>
    <name>E9GMI9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC protein, subfamily ABCH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_104532</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732552">
        <property type="protein sequence ID" value="EFX79372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79372"/>
    <dbReference type="EnsemblMetazoa" id="EFX79372">
        <property type="protein sequence ID" value="EFX79372"/>
        <property type="gene ID" value="DAPPUDRAFT_104532"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_104532"/>
    <dbReference type="eggNOG" id="KOG0059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014367_1_0_1"/>
    <dbReference type="InParanoid" id="E9GMI9"/>
    <dbReference type="OMA" id="SIVWINI"/>
    <dbReference type="OrthoDB" id="1127273at2759"/>
    <dbReference type="PhylomeDB" id="E9GMI9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="648"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX79372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="738" mass="81924" checksum="E811F6C7AC42873E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9GMZ2</accession>
    <name>E9GMZ2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_319836</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732553">
        <property type="protein sequence ID" value="EFX79179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79179"/>
    <dbReference type="EnsemblMetazoa" id="EFX79179">
        <property type="protein sequence ID" value="EFX79179"/>
        <property type="gene ID" value="DAPPUDRAFT_319836"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_319836"/>
    <dbReference type="eggNOG" id="KOG1052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1257200_0_0_1"/>
    <dbReference type="InParanoid" id="E9GMZ2"/>
    <dbReference type="OrthoDB" id="1711184at2759"/>
    <dbReference type="PhylomeDB" id="E9GMZ2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX79179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="220" mass="25208" checksum="1ADC9BABF052DC9B" modified="2011-04-05" version="1">MVVFIYVYTGVLTALLAVPNYVPIINTLDELATSSTIKPVTIKSTAVDDIMLNAKNGTYKLIGDTFRKFPNETLVANTLVGVQRAVEGKYGFLEPRMSLLSLMENDRKEQNSCRVTLAKQTFYPRAFAYLLPKKSPFKDAFDRQILLLQQYGFIIHFQTKIVLQSNRCLLLKKKVRSRPPIFTLNHVSSSFVILVFGFAVSFLCFVFENMWNFIDYLYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9GNH2</accession>
    <name>E9GNH2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_53050</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732555">
        <property type="protein sequence ID" value="EFX78958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78958">
        <property type="protein sequence ID" value="EFX78958"/>
        <property type="gene ID" value="DAPPUDRAFT_53050"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_53050"/>
    <dbReference type="HOGENOM" id="CLU_090083_1_1_1"/>
    <dbReference type="InParanoid" id="E9GNH2"/>
    <dbReference type="OrthoDB" id="1305843at2759"/>
    <dbReference type="PhylomeDB" id="E9GNH2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010216">
        <property type="term" value="P:maintenance of DNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="PTHR14140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="3">
        <location>
            <begin position="1"/>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX77880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="65" mass="6799" checksum="B0696B9CF774D716" modified="2011-04-05" version="1">MLCASAPGKDTCQGDSRDSGGSIIVTGVLVGTTSWGSGCADSRKSNSKMNEDNERVSDCDTYYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E9GSC3</accession>
    <name>E9GSC3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF_DOMAIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_213340</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732561">
        <property type="protein sequence ID" value="EFX77684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77684"/>
    <dbReference type="EnsemblMetazoa" id="EFX77684">
        <property type="protein sequence ID" value="EFX77684"/>
        <property type="gene ID" value="DAPPUDRAFT_213340"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_213340"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465601_0_0_1"/>
    <dbReference type="InParanoid" id="E9GSC3"/>
    <dbReference type="OrthoDB" id="1154048at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027725">
        <property type="entry name" value="HSF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="PTHR10015"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF_DOMAIN" evidence="6">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX77684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="586" mass="65262" checksum="B0D039D265FE9DB8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9GSQ8</accession>
    <name>E9GSQ8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein LOPB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOPB2</name>
        <name evidence="19" type="ORF">DAPPUDRAFT_305771</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732562">
        <property type="protein sequence ID" value="EFX77470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77470"/>
    <dbReference type="EnsemblMetazoa" id="EFX77470">
        <property type="protein sequence ID" value="EFX77470"/>
        <property type="gene ID" value="DAPPUDRAFT_305771"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305771"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009579_3_0_1"/>
    <dbReference type="InParanoid" id="E9GSQ8"/>
    <dbReference type="OMA" id="CINETIK"/>
    <dbReference type="OrthoDB" id="732872at2759"/>
    <dbReference type="PhylomeDB" id="E9GSQ8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008020">
        <property type="term" value="F:G protein-coupled photoreceptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071482">
        <property type="term" value="P:cellular response to light stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000856">
        <property type="entry name" value="Opsin_RH3/RH4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00577">
        <property type="entry name" value="OPSINRH3RH4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F1_2" evidence="18">
        <location>
            <begin position="73"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFX77470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="386" mass="43262" checksum="FDFF4A6B41D37FAD" modified="2011-04-05" version="1">MNQSTELTATAMAQHGGYNPWVLPDSFTILSFAPEDIRGFLHPHWHTQKSPHPMLYYFFGLYYLVMGSIAICGNIIVLRIFSNNQNLRTPANMLVMNLAMSDLLLMVTLIPECVYNFFLGGPWQFGELGCQIHSFCGALMGYNQIMTLTLISWDRYNVIVKGFNGTPLTFSRAIILIIFSWVWALGWSIAPLVGWGLYAMDGMLGTCSFDAVTTTMNNKSYLMAAFFSNYVLTVSSIIICYYFIVQAVFHHEDELRQQAKKMNVTSLRSNADQQAVSAEIRIAKIAILNVTLWLISWTPFAVICLLGTWGDTSKITPLVSELPIILSKTSCAYNPVIYALSHPKYREALKELYPWICIVPNTKKSNQNGGDNQSVSSAKTQASEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GT76</accession>
    <name>E9GT76_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_321622</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732563">
        <property type="protein sequence ID" value="EFX77320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77320">
        <property type="protein sequence ID" value="EFX77320"/>
        <property type="gene ID" value="DAPPUDRAFT_321622"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_321622"/>
    <dbReference type="HOGENOM" id="CLU_1760635_0_0_1"/>
    <dbReference type="InParanoid" id="E9GT76"/>
    <dbReference type="PhylomeDB" id="E9GT76"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX77320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="148" mass="17174" checksum="0B6EC4A1C5443351" modified="2011-04-05" version="1">MDKFMAKSYLASLNKSGFGSLGPTDENWKGIFNRFDKVEKGKGLAPNKPIPEYLVDKNALLFESSKFEGNFYSLLKKSYNPDVWLFLPGIEIMYCSYLRSFFPEEYKENKDGVKCYYFECHKSFFVMPHVLRAAEPPNPFDCIKQEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTM0</accession>
    <name>E9GTM0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_106354</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732564">
        <property type="protein sequence ID" value="EFX77103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77103">
        <property type="protein sequence ID" value="EFX77103"/>
        <property type="gene ID" value="DAPPUDRAFT_106354"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_106354"/>
    <dbReference type="eggNOG" id="ENOG502TF5C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_624480_0_0_1"/>
    <dbReference type="OrthoDB" id="1799511at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237427" evidence="1">
        <location>
            <begin position="23"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="439" mass="46809" checksum="662B8FCAFA88AF79" modified="2011-04-05" version="1">MSPLVSSRLMVILAVCVVGLWCHPMPEKDNNTNDGALNPLLKKMNDLGQLNDFADSDYHDTVTDFLRLSTTSPTVATSTKKSVVTTPSTLSPSTTIKTTIAQTTTDKSPSSSGVTKAFEVATAKFFPSVAPTIVMTTGKPTTAAPPVAEALAPKLETLAPVVATPLPFVEKLQKTNKPAPLNEIEPLTKPTFVAQTTAMPPISNVSQKKLIPDLATLTQQSPAIPTARPAVSGSIKQQAVPAVQRQPVAVLNQPQQQQMAVSGAASIQQQPTNLVQTAASSTATAPRQQQPNFAPMAVPISTQQQQQPVMQNPARMQPPMMPTMLNAAQSATQQQMMMQNPAVMQQMMMRNPVFQQQQFQQMLQNRPQFSTRVSTSTAKPGVQKTAAPAVMTLISNPLFGSNGRPVFFLGGNGTPTKMFPISSLPQLLSPPVANTASPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTT5</accession>
    <name>E9GTT5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_54608</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732564">
        <property type="protein sequence ID" value="EFX77129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77129"/>
    <dbReference type="MEROPS" id="S01.A53"/>
    <dbReference type="EnsemblMetazoa" id="EFX77129">
        <property type="protein sequence ID" value="EFX77129"/>
        <property type="gene ID" value="DAPPUDRAFT_54608"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_54608"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_0_0_1"/>
    <dbReference type="InParanoid" id="E9GTT5"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="PhylomeDB" id="E9GTT5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX77129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="239" mass="27001" checksum="6685F9B98D40F748" modified="2011-04-05" version="1" fragment="single">NDWPWMVALLASHQNNRLFCGGVLINEWFVLTAAHCLNDKRTEEVTVRLGEFHFRWPSLSRRDHEVERIDIHEKFNPKTFDYDIAVIKLSEKADMRDKAGNSGNIWPICLPPPGVQLESKNAFVAGWGKTSHGGFPSEVLLDANLPIWRRNECEQVFHIRSDPIDYRYQFCAGPKDGEEDACDGDSGGPLMYKMESGRWAVVGIVSWGIDGKCAVAGQPGVYTRVSAFSDWIYHKISST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTV5</accession>
    <name>E9GTV5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_321773</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732564">
        <property type="protein sequence ID" value="EFX77141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77141">
        <property type="protein sequence ID" value="EFX77141"/>
        <property type="gene ID" value="DAPPUDRAFT_321773"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_321773"/>
    <dbReference type="HOGENOM" id="CLU_1950953_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="129" mass="14488" checksum="E2C8481D30C25422" modified="2011-04-05" version="1">MNEASDTIRKKKLVVGVRQQQRLRKFAAVQMLEEMIDPNTIIDTQPVIAIPELVDDPVQQHTPDINSIGENAFNFVDGARPDASEPYSFADTTEEDNFSSDADSYQAFDDDDGEEACELLSDMQSLREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9GU08</accession>
    <name>E9GU08_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CDC48_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_321819</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732565">
        <property type="protein sequence ID" value="EFX76952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76952"/>
    <dbReference type="EnsemblMetazoa" id="EFX76952">
        <property type="protein sequence ID" value="EFX76952"/>
        <property type="gene ID" value="DAPPUDRAFT_321819"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_321819"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1322103_0_0_1"/>
    <dbReference type="InParanoid" id="E9GU08"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="1">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="208" mass="23221" checksum="488D5E98ED6AEA0D" modified="2011-04-05" version="1">MDGYYFESGKLPMSIANKQFDPVWLTVENDLNEDGVVYLSKEAIDSLELSSGDSVLIKGKQSKETVSIPHADDAIIDFNEIRMDSSIRDYLRVSLGDKVLMSPVKYNKFGKIIHALNSDAMIAKSDVSDVDGLVKELPNLELGGPSGDTSDVDKNVDEKKLVLFNSVVVPVPDTVSKCIVDEVQSQREKEERLMKPNFEEIMRFCEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9GVF0</accession>
    <name>E9GVF0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKS_ER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_306158</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732568">
        <property type="protein sequence ID" value="EFX76404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76404"/>
    <dbReference type="EnsemblMetazoa" id="EFX76404">
        <property type="protein sequence ID" value="EFX76404"/>
        <property type="gene ID" value="DAPPUDRAFT_306158"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306158"/>
    <dbReference type="eggNOG" id="KOG0025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_17_1_1"/>
    <dbReference type="InParanoid" id="E9GVF0"/>
    <dbReference type="OMA" id="HQLCRAW"/>
    <dbReference type="OrthoDB" id="1269870at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019166">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="2"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="300" mass="33455" checksum="2347A00CCE50D388" modified="2011-04-05" version="1">MVQSPINPADINTIQGVYGVKPNLPFTLGNEGFGSIEEVGSEVKNLKVGDWVIPGMNAWGTWRTHALEEEKNLLKIPNDIDPAMAATLAVNPGTAYRMLKDFEKLNKGDIVLQNAANSAVGQNVIQIARQLGFRTVNILRNREGIDKLKQELQDLGADYVLTDEEFRSSKLFKSGDLAPPKLVLNCVSGKAVIELVKAMADNATLVTYGGMSRQPLVVPTSAFIFKNIRLVGYWMTRWNWKHGIESHERREMLDTLCAMARQGTLRAPKHELVPLDSYKDALARSCDTSRFHEAKLIFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
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            <taxon>Anomopoda</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="220" mass="24850" checksum="C3452BAC68023AF2" modified="2011-04-05" version="1">MAIQRDGLILGGRRNDRYKRKISYIKKIVARPYMTFAWLEPIASLADVQRTTTLTSTSTLKSTVTVTSKFVCAKLVNVTGLCRRRRGLLIDEPVILSFDDQLDEFIDDAFTRVLHPGQFVATRTLGAEVTPLVVLPDGIEEHPDIFHRRPNSNSTETMDVIESSIKMNDSQRRMLGDDDPQSRIYFAQLAAFANSIFDAIRPSTVTLTTTITVTRKTRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
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    <name>E9GVT5_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_249078</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="216" mass="23408" checksum="2D84BF55B4346E0C" modified="2011-04-05" version="1">MMLALAHQRQSLMQHKYNWILVQIIKLLPLYIMTRLRILIKAEELISQDKACCIALHRDTFYNTGALDLYYRQAAAALSQRVSPTALQQQQQQQQQPPRGGIYPSSAGTGGPAGALSLSLLPGNNSPGQRSSTSSSLLSNSAAGASANAAANASSNLSRPSSIIDKRPTAPQQQQQRKRLLHQPGGGFRCDVEKLALVLNSSVRSNAPIRDILNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
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    <name>E9GX30_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX76009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_322831"/>
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    <dbReference type="OrthoDB" id="1684169at2759"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="576" mass="64160" checksum="9211661A0FD3413F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
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    <name>E9GX49_DAPPU</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX75925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75925">
        <property type="protein sequence ID" value="EFX75925"/>
        <property type="gene ID" value="DAPPUDRAFT_107455"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_107455"/>
    <dbReference type="HOGENOM" id="CLU_1410152_0_0_1"/>
    <dbReference type="InParanoid" id="E9GX49"/>
    <dbReference type="PhylomeDB" id="E9GX49"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="193" mass="22023" checksum="5BE05CED6219D6B1" modified="2011-04-05" version="1">MTDQQLFAVQFSSSSFSFWKNCIFVDDHKFGLNAAGDLISVPMRYSRQRSVLVTGCVSCDYPREIHCVEKTRSVDQYLGVLEKVAAVGRTIVHMRSPIRSSARVKTWIASRDMSSILWPTKSTDIMPMTSIWRSFINEFNMASPGIGNFNELWGEIQSSWLTFVENEYFVLSATVGYLWLDLSDIAEEYNASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9GXZ1</accession>
    <name>E9GXZ1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_199244</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732574">
        <property type="protein sequence ID" value="EFX75648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75648">
        <property type="protein sequence ID" value="EFX75648"/>
        <property type="gene ID" value="DAPPUDRAFT_199244"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_199244"/>
    <dbReference type="eggNOG" id="ENOG502S4BB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077993_0_0_1"/>
    <dbReference type="InParanoid" id="E9GXZ1"/>
    <dbReference type="OMA" id="RCAGCVH"/>
    <dbReference type="OrthoDB" id="775873at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="MHCK_EF2_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX75648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="244" mass="27978" checksum="D7C3FBBD3388374B" modified="2011-04-05" version="1">MANFARENNATEAEINLDYVFATGAFKYVYKGRYTKGRRAGQECVCKIFKSGSVFEESYFRVELDVVAKALEVVNSFNKDKVINESIWLNKPTIWTFMPGSEREGEKHLIEPLIFNFEKFNSNTGWTPRKSSPWIDVMQALSHYSYHSSNRSLLFCDLQGGVYKDGFIITDPVIMSTAQEYGPTDLGPAGISTFFARHKCNEYCNSGWIIPHDRRQYFHVQKGTTMVLPTRQSRTPLTYKKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYC1</accession>
    <name>E9GYC1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_250330</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732574">
        <property type="protein sequence ID" value="EFX75575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75575">
        <property type="protein sequence ID" value="EFX75575"/>
        <property type="gene ID" value="DAPPUDRAFT_250330"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_250330"/>
    <dbReference type="HOGENOM" id="CLU_977482_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="2">
        <location>
            <begin position="78"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX75575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="285" mass="31960" checksum="F43F786CD84907A0" modified="2011-04-05" version="1">MKSREIAVIIVEGYVHDNDDQNNTLYGYLATFMIKRKLSVEPDGSTITTVSKFPEGDHHLHIPKAYPELDDSSDSEPDDDNDDFRELLMKCVGGEKDTVSFLNTFSSAKRRKIHNICDQLTIVQKSTVEGDLRRLVVTRVPLTPHGVICVIPSVFPTVRVVRDLTSLMPATPTMTEGWIGQMPRSKRVRKSVNYAESDLSSLTEPNSQVYDTSRRRSRRARDQLPFSPASPSVVEIAPERASSRSSMPPLEPIFPPTLPSAEEESSRASSPYNFCFQHELEASYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYV9</accession>
    <name>E9GYV9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_323447</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732576">
        <property type="protein sequence ID" value="EFX75224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75224"/>
    <dbReference type="EnsemblMetazoa" id="EFX75224">
        <property type="protein sequence ID" value="EFX75224"/>
        <property type="gene ID" value="DAPPUDRAFT_323447"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_323447"/>
    <dbReference type="eggNOG" id="KOG4293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1139008_0_0_1"/>
    <dbReference type="InParanoid" id="E9GYV9"/>
    <dbReference type="OrthoDB" id="1064366at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
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        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOMON" evidence="2">
        <location>
            <begin position="168"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX75224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="244" mass="27730" checksum="ABA96E2C92DC20B3" modified="2011-04-05" version="1">MKLTEPEPEPEPSLVLSREPETSPEPTPELSPIEIVNESKAKPMEPKPITEVTVPELEMTAPEPNLNHLLSQSQPQSPNQPRDRTQIDVAVGQFYGGRQDLAATLGFERDGQTIILFRHKLNSSDEADHIIGSEPMQVIWVRGQEHGKYVHRPEWKYPVSCDPFEMDCNYYAKWEYLELSDHICFTIMANHTNRWVAIGLSETTSKPQTDVVLGWVNANGRAFVDDMWDVLWDSTLILSDSYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0Q5</accession>
    <name>E9H0Q5_DAPPU</name>
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        <recommendedName>
            <fullName evidence="1">Peptidase_M1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_324110</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732581">
        <property type="protein sequence ID" value="EFX74708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74708"/>
    <dbReference type="EnsemblMetazoa" id="EFX74708">
        <property type="protein sequence ID" value="EFX74708"/>
        <property type="gene ID" value="DAPPUDRAFT_324110"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_324110"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1679729_0_0_1"/>
    <dbReference type="InParanoid" id="E9H0Q5"/>
    <dbReference type="OMA" id="YGNANSK"/>
    <dbReference type="OrthoDB" id="110058at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
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    </dbReference>
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        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="P:peptide catabolic process"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="APN-like"/>
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        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF246">
        <property type="entry name" value="PTHR11533:SF246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="157" mass="17881" checksum="8C6CC488112DEC56" modified="2011-04-05" version="1">MPQVVEVRSPRGELLSNLDAVVVKYQQQIQSDLVFCRVTCYITQLISASFKSEIHEIFDRISYGKGATIIQMLAAFLGEKTFRQGLTNYLKSRQYGNAVQDELWDALTKPRTKQAKVDKVPLPTDVKQIMDTWTLKMGFPVVTVTREYEKNSVSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2K2</accession>
    <name>E9H2K2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_57634</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732586">
        <property type="protein sequence ID" value="EFX74049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74049">
        <property type="protein sequence ID" value="EFX74049"/>
        <property type="gene ID" value="DAPPUDRAFT_57634"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_57634"/>
    <dbReference type="eggNOG" id="ENOG502SUNW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_39_4_1"/>
    <dbReference type="InParanoid" id="E9H2K2"/>
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    <dbReference type="PhylomeDB" id="E9H2K2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
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        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="4"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="353" mass="40146" checksum="E6582058B0FA0E55" modified="2011-04-05" version="1" fragment="single">NGFDVLAITETWLSAERGDDDLRMLCPDGFNVFHSPMMGRTGGGVAVLARDTIDVTTFDSLDSTPKSFEHMVLSLTINAVCVRLIVVYCPPKSKPSVPFQCLMKELATYLEFLSVSSGKVIIVGDFNLHIDNPDDSNVIRFVALLESLSWVQHVKGATHIRGHTLNLVISRSSDKLVSESFISVLISDHFAVVTVVRAHRQAVPMKSISFRSTSAIGLDRFESDIAKIPFVVSPSDFLDDLFNQYNMGTRDVLDQHAPLKHRRFAVRPVNPWFSGEIYQARRQMRKFERVWRRRRLEIDKEILLHHKNQLARLVIDSKLTYFRTKMTECGPNRKALYRLLDRCLLKEKGHSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2K9</accession>
    <name>E9H2K9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_109301</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732586">
        <property type="protein sequence ID" value="EFX73991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73991">
        <property type="protein sequence ID" value="EFX73991"/>
        <property type="gene ID" value="DAPPUDRAFT_109301"/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Basu M.K."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Lucas S.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="113" mass="12998" checksum="CF8A2E502531F17B" modified="2011-04-05" version="1">MWINSWILENRYSYLRFLVTRSTDIYFSQIENKITYPSYNDSPISAHHKGKQLMQGLWQHCLLDFDSAREIVTAFTVVVSKLAVTTIAGTDNQVSDWNGGVPVVKPDKETRML</sequence>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX71426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_111737"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_111737"/>
    <dbReference type="HOGENOM" id="CLU_1241246_0_0_1"/>
    <dbReference type="OrthoDB" id="1771253at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="223" mass="25831" checksum="14D39FBDC322AF0A" modified="2011-04-05" version="1">MEEERTINPYRSAEIPSISDRLEFLFDNPLQIQELTFKENCKPLNEILDLTCSPNLQVNQDIAHSERYQIVNFQRLIFSYHANRLYLRVVDAKARPVVLVLPPENVAAFVNSSRDAYSTLLADWDRAPPVVIELFNSSFTFSHRSRYGILVYDFVFRSWELIGFIAPLGCDKSESGQSPNPIIRLIEYFQPNLKKVNRKRTSTCRKRTSPKNKTNRSTAQISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HAD2</accession>
    <name>E9HAD2_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_255932</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732611">
        <property type="protein sequence ID" value="EFX71287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71287">
        <property type="protein sequence ID" value="EFX71287"/>
        <property type="gene ID" value="DAPPUDRAFT_255932"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_255932"/>
    <dbReference type="HOGENOM" id="CLU_2280229_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="102" mass="11214" checksum="AFAFA755BF92EB04" modified="2011-04-05" version="1">MASAPFSFLLSAPSWPTSGPRRRQQFSREPAGGGGVGATHFQQVGFRVTYGLYTTDGRLARVAPTTAIGGQQLANLFKRGTRNRFLRLFQFRVPAVDFCSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HB45</accession>
    <name>E9HB45_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_327603</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732614">
        <property type="protein sequence ID" value="EFX71021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71021">
        <property type="protein sequence ID" value="EFX71021"/>
        <property type="gene ID" value="DAPPUDRAFT_327603"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_327603"/>
    <dbReference type="HOGENOM" id="CLU_1827233_0_0_1"/>
    <dbReference type="InParanoid" id="E9HB45"/>
    <dbReference type="OrthoDB" id="222689at2759"/>
    <dbReference type="PhylomeDB" id="E9HB45"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX71021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="165" mass="18151" checksum="9DD5AE78FD4C98C8" modified="2011-04-05" version="1">MADTARLNGLRGGNRSAATRLINRINNILADAALSRTQKIHELQSKITALDAKLSAIEGYDAAIFNEIDDEDLQAEMDATDAINQTIRDASENFMFQLKTLQDAEDAANAALALATAPVVTVAATPGPSAKSRHFIYFALKIEKTRKNFEKRIMTYTDLNLRHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9HB48</accession>
    <name>E9HB48_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_60686</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732614">
        <property type="protein sequence ID" value="EFX71031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71031"/>
    <dbReference type="EnsemblMetazoa" id="EFX71031">
        <property type="protein sequence ID" value="EFX71031"/>
        <property type="gene ID" value="DAPPUDRAFT_60686"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_60686"/>
    <dbReference type="eggNOG" id="KOG2456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_3_0_1"/>
    <dbReference type="InParanoid" id="E9HB48"/>
    <dbReference type="OMA" id="AINIDVG"/>
    <dbReference type="OrthoDB" id="646662at2759"/>
    <dbReference type="PhylomeDB" id="E9HB48"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="533"/>
            <end position="554"/>
        </location>
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        </location>
    </feature>
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        <location>
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            <end position="490"/>
        </location>
    </feature>
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        <location>
            <position position="203"/>
        </location>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
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    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <name>E9HEI7_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        </location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="GGT_peptidase"/>
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        <property type="entry name" value="GGT_ssub"/>
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        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="g_glut_trans"/>
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    </dbReference>
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        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX69497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="623" mass="67645" checksum="AE8177F455296FB0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGK0</accession>
    <name>E9HGK0_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DAPPUDRAFT_259105</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732642">
        <property type="protein sequence ID" value="EFX69097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69097">
        <property type="protein sequence ID" value="EFX69097"/>
        <property type="gene ID" value="DAPPUDRAFT_259105"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_259105"/>
    <dbReference type="HOGENOM" id="CLU_2225816_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX69097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="106" mass="12321" checksum="D2DAFAD4FE81D599" modified="2011-04-05" version="1">MISVVSSSSGVVASLLLHKTPATQQQRTLKKKTNATIVNRPPVNIGSPGYLMRATTDQQMLYVLYYTLLYSTPVLYFNQNFFQRNYFLVRVHFIHRDWIVLRLLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9HI69</accession>
    <name>E9HI69_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-binding protein 48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_301410</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RBM48 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732653">
        <property type="protein sequence ID" value="EFX68564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68564"/>
    <dbReference type="EnsemblMetazoa" id="EFX68564">
        <property type="protein sequence ID" value="EFX68564"/>
        <property type="gene ID" value="DAPPUDRAFT_301410"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301410"/>
    <dbReference type="eggNOG" id="ENOG502QSNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9HI69"/>
    <dbReference type="OrthoDB" id="1117000at2759"/>
    <dbReference type="PhylomeDB" id="E9HI69"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12442">
        <property type="entry name" value="RRM_RBM48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039599">
        <property type="entry name" value="RBM48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034264">
        <property type="entry name" value="RBM48_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20957">
        <property type="entry name" value="PTHR20957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="55"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX68564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="226" mass="25891" checksum="C495C9BBD05E57AA" modified="2011-04-05" version="1">MENTFVLSKQIHHERQELCTNRPRYRQGKKLTAVKVYSVVDESQYLLIDKVPAIAVTAELETLCQGFGSIEYLKHLPDYPTEKFCEVFQVKFHTIQSARFAKRKMDDRNFYGGTLHVCYAPELETLNDTRSKLNNRRQEIENKLKAPQNRKHKLLSATSTSAEQVHCPSLVIKEPISDSNAECFTTTEPPNSEESQKVTVAGKQPQPVCEPPKKRIVYHVSSKTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9HIM6</accession>
    <name>E9HIM6_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732656">
        <property type="protein sequence ID" value="EFX68415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68415"/>
    <dbReference type="EnsemblMetazoa" id="EFX68415">
        <property type="protein sequence ID" value="EFX68415"/>
        <property type="gene ID" value="DAPPUDRAFT_114582"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_114582"/>
    <dbReference type="eggNOG" id="KOG4409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2212531_0_0_1"/>
    <dbReference type="InParanoid" id="E9HIM6"/>
    <dbReference type="OrthoDB" id="1555935at2759"/>
    <dbReference type="PhylomeDB" id="E9HIM6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX68415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="107" mass="11597" checksum="FB73C3A84EEC7C40" modified="2011-04-05" version="1">MGSGFQCAKHPMENRLPALEPGIPITFIYGANSWIVREPGLWIVKKRRNGSTVNLHVIGGNGHHVYADKVNKFNKIVLGACMETDNRKSAAATARVGHHSPPNASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKG5</accession>
    <name>E9HKG5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_115164</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732668">
        <property type="protein sequence ID" value="EFX67784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67784">
        <property type="protein sequence ID" value="EFX67784"/>
        <property type="gene ID" value="DAPPUDRAFT_115164"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_115164"/>
    <dbReference type="HOGENOM" id="CLU_065876_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0031054">
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    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="258" mass="27940" checksum="3581B4A12A1D81CD" modified="2011-04-05" version="1">MQEVRGQRLKGITENLNATAKSLLLVPGVLADLFESVGGAIYKNSGFSRKAVLKSYTLFLVHAYATPENGNATTESLLVPGVLADLFEAVADAIYKDSGYSRKAVVKSFTPFLYQAYVIIAMMWMGHISHNANPDGSVDIYGKGTRPGVGMSIRVDKRPGYSVDMGYGVIMDHVKLGPRLGQDVMLPSPGVKNFVVGQEKTGKDTIHCVDLDGMGTPATRDTGYLGGRHWIPRPTLATHKADTGYPDTGYPTLATQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLC6</accession>
    <name>E9HLC6_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_115443</name>
    </gene>
    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732678">
        <property type="protein sequence ID" value="EFX67454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67454">
        <property type="protein sequence ID" value="EFX67454"/>
        <property type="gene ID" value="DAPPUDRAFT_115443"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_115443"/>
    <dbReference type="HOGENOM" id="CLU_827064_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="336" mass="36864" checksum="045AC5E06AE97238" modified="2011-04-05" version="1">MSEEENETIDTIEEEMDIIEVDQELETTADEPLEELTKDPFIAKLASFPENPMDIATRQSASTINHDDASLAILQPKPRNKKKSSSVRNYEDRSIRKKAQNYFNVMEKGQFFTLKYARVEKVVITDQIYPLIHEIIQAEKTQVPKRFGDFVLDSEGRGLDGRRGRGGRGGSEDAAGRASGQSEHAAAHVSVRGRGGRGGLGRASGQSEHAVTSAMVHPTNLGTADIVLFGLPSPLDGIPNTVARMASAESEYRSSRGSIPDVIEEHSLVPTPDMDGLLPSGQTSINGRAKTDSYSAALGEDEENYSLSINNEVSSVEDNESCKCEERRRRRGGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLE5</accession>
    <name>E9HLE5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_261661</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732678">
        <property type="protein sequence ID" value="EFX67423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67423">
        <property type="protein sequence ID" value="EFX67423"/>
        <property type="gene ID" value="DAPPUDRAFT_261661"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_261661"/>
    <dbReference type="HOGENOM" id="CLU_2656962_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="76" mass="8456" checksum="9BF24ED8A1B8C4D0" modified="2011-04-05" version="1">MVKREEFGKFCRIDNTISALCRFGKSNSANPFFFRIDQLPPLPSHPVTLTQRSTSIPGPPALLNGKQLKPATNNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLF5</accession>
    <name>E9HLF5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_261674</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732678">
        <property type="protein sequence ID" value="EFX67431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67431">
        <property type="protein sequence ID" value="EFX67431"/>
        <property type="gene ID" value="DAPPUDRAFT_261674"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_261674"/>
    <dbReference type="HOGENOM" id="CLU_2040388_0_0_1"/>
    <dbReference type="OrthoDB" id="1152704at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006833">
        <property type="term" value="P:water transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="121" mass="13342" checksum="A410F8E72084939E" modified="2011-04-05" version="1">MEQKSLHQDLFRSKNRPDPFAEQKGEIYVIAKEVIGKWRSFVSVTSPGHQGYLGATIVSTGLTDWQALSIELCLTFVITLVYLIAFDDSQVTIMTTLNAEALKNALLEGLSSPINGLSPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLV5</accession>
    <name>E9HLV5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clavesin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Retinaldehyde-binding protein 1-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_64016</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Early endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endosome membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Trans-Golgi network membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732682">
        <property type="protein sequence ID" value="EFX67276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67276"/>
    <dbReference type="EnsemblMetazoa" id="EFX67276">
        <property type="protein sequence ID" value="EFX67276"/>
        <property type="gene ID" value="DAPPUDRAFT_64016"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_64016"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046597_1_0_1"/>
    <dbReference type="InParanoid" id="E9HLV5"/>
    <dbReference type="OMA" id="WYVETAL"/>
    <dbReference type="OrthoDB" id="872816at2759"/>
    <dbReference type="PhylomeDB" id="E9HLV5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028634">
        <property type="entry name" value="Clavesin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF72">
        <property type="entry name" value="PTHR10174:SF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="SSF46938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="SSF52087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="11">
        <location>
            <begin position="57"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX67276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="241" mass="27828" checksum="B835BB1F46E1808E" modified="2011-04-05" version="1">MHIFVGTLQTDDEFLMRFLRARKLCVKDALEVYENYYRFLHRNRELCFGLKIDDAEIKQALEDGLPGVIQRRDSRGRRIMVLFAAQWDPSRYSISAIHKALYLSLNLLLQDCVVRERGLILVIDWSQFSFQQCSKLQPAALREIAEGLEYCYPVRFKSIHCVAQPWYIEAAVSLLKPFLRGTSRGKIFSHGNNLSSLHQILSREILPAELGGEQGPYQSSLWIDNLIRASHDTPDRNQSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9HMC2</accession>
    <name>E9HMC2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_115736</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732685">
        <property type="protein sequence ID" value="EFX67117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67117"/>
    <dbReference type="EnsemblMetazoa" id="EFX67117">
        <property type="protein sequence ID" value="EFX67117"/>
        <property type="gene ID" value="DAPPUDRAFT_115736"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_115736"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_5_2_1"/>
    <dbReference type="InParanoid" id="E9HMC2"/>
    <dbReference type="OMA" id="YDEEMWE"/>
    <dbReference type="OrthoDB" id="110058at2759"/>
    <dbReference type="PhylomeDB" id="E9HMC2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Zdobnov E.M."/>
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                <person name="Thomas W.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
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            <begin position="229"/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2742600_0_0_1"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="71" mass="8270" checksum="9CEA06FC122D7A3A" modified="2011-04-05" version="1">MCKNESHPLYGYFMAKVSATIFECDADDVNRLIEAKKSELKITRISNPSKETVMKAINKYEMAKHCRWKAR</sequence>
</entry>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX65187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX65187">
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        <property type="gene ID" value="DAPPUDRAFT_117487"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9HU35</accession>
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            <fullName evidence="1">Rho-GAP domain-containing protein</fullName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_7686"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_65955"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_65943"/>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="153" mass="17285" checksum="27722B5A835BFF97" modified="2011-04-05" version="1">MYGRRLNTLPYSEETNEEKFDASYGDKPDELKKAVARHQTLLQHFGKRFLASYLPALREYHQATKKNNPTVIKERDVVLVHDDKPRKDWKMAVVEKLIRSQDGQIRAADIRTANGKTNRPISKLYPLQVAEPSDDPAGSSDGPLFGSSSVVAF</sequence>
</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="InParanoid" id="E9HWR2"/>
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    <dbReference type="PhylomeDB" id="E9HWR2"/>
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        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="135" mass="15673" checksum="12A0ECE8D0256E5A" modified="2011-04-05" version="1">MLKKKGLTKKFLPKYIGPFQIVKKVAETTYRVEELPSRRKKKVVRRFNAHVVQLKPFRARSDEWHVSEIDEPTGSENDSENRSEAEVTQLAVVPVMEEIPAQQLLVSEFPNRPPVRTRSGRISRLPTIFEDFDLN</sequence>
</entry>
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    <accession>E9HY25</accession>
    <name>E9HY25_DAPPU</name>
    <protein>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="4">
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
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            <end position="111"/>
        </location>
    </feature>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX62852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="167" mass="19109" checksum="2EB0051C5BE64663" modified="2011-04-05" version="1" fragment="single">MDNIWADFKNSSLKWMFRSIMALSMSQNKQVVTNLKEADAKQLKQPKLEVSKYPHVLGEVEESRVDFENLLCQKILTYLGRKRRKMGIKKSTKGGRPTLNKNKKISDGRARRTTVGDTELDLVSYKANNEKMLDLYANSNGVISQALITLWKETYAGRRKPIEDGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX62800.1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="217" mass="24430" checksum="E01CE2930D325330" modified="2011-04-05" version="1" fragment="single">MSKFVMLNIINELHNEPEKILEPISLHRSVHQHLPQLHGVIAKAKAIAIQSSPMLTKKQTKKSGAASSSAHELSKIKNNFHGESPLADDVSRSENKASKWRDSDIPALIRILHGNIRSKHAIAEEFLLHLEQNRAGENKNGPLKEQILAKIAEISSWGKCTEAGAMNGRKCRLVQSDVLERYNLHELSAINTWEFVTETKKRRRKADDSRTEEDTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <name>a divalent metal cation</name>
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        </cofactor>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="131" mass="14508" checksum="2668536DE5E5C8DC" modified="2011-04-05" version="1">MADRGFTVHVAVTLRNANLAVPSFLGKQTQLSNVEVEYFRGLARIRIHVERVIGATKQRFTILEGPLHRATLSVSKGEDSAIIDKIVMVCCALYNSCSSVVPVERQNPHPSVGMLFSIHPNSPPRFCQARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
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                <person name="Yamagata H."/>
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                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_120054"/>
    <dbReference type="HOGENOM" id="CLU_1397632_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9I061"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="109"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX62618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="195" mass="22207" checksum="2E6B2FA7E69B17FB" modified="2011-04-05" version="1">MEDDFMNENDPRNLFVHRTTAKRTHTTLLNRARAMLSREASHQEFAAFTPRLNQAHTRLVGIHQRYVQLADLSDAEQHTAELYLQAINNQQLTCLRTIAVAMANRSGRRRSWNVSNHDNASRNRTEPIQPNVPGEVPNAPLNNTAPNQINWEENQQHDPMSLPTPLVENNDNHSIDANYINGQINDREEAVTEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9I0X6</accession>
    <name>E9I0X6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    <gene>
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    </gene>
    <organism evidence="4">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Shiga Y."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <source>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Lopez J."/>
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                <person name="Pritham E.J."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
            <dbReference type="EMBL" id="EFX61800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="96" mass="10837" checksum="D734DA2AB0DB0AA5" modified="2011-04-05" version="1">MTGHMKIQKEAEQRLVLVSDFHEPLTGPLRSGVRTFYEGFLDSPLNREIEERYGPMFSKEPPMIAFRAGRSLGSMLGPIFKKGPTVPTIRSEKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9I4C9</accession>
    <name>E9I4C9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_122492</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734988">
        <property type="protein sequence ID" value="EFX61151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61151">
        <property type="protein sequence ID" value="EFX61151"/>
        <property type="gene ID" value="DAPPUDRAFT_122492"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_122492"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_326599_0_0_1"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX61151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="882" mass="100705" checksum="8AFC8FCD399B2DA4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9I4S5</accession>
    <name>E9I4S5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_122641</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL735172">
        <property type="protein sequence ID" value="EFX61006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61006">
        <property type="protein sequence ID" value="EFX61006"/>
        <property type="gene ID" value="DAPPUDRAFT_122641"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_122641"/>
    <dbReference type="eggNOG" id="ENOG502S18N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112614_2_1_1"/>
    <dbReference type="InParanoid" id="E9I4S5"/>
    <dbReference type="OrthoDB" id="1513158at2759"/>
    <dbReference type="PhylomeDB" id="E9I4S5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX61006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="97" mass="10629" checksum="888BE4FB873E3EAF" modified="2011-04-05" version="1">MIGRADIEGSKSDVAMNAWPPQASYPCEWPKGSIXRAFAVRIRTENRDQAGICPFALREVSVLPEPALGHLRYRLTDVPPQSNSPSGNVLSPDRATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9I624</accession>
    <name>E9I624_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_19892</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL736076">
        <property type="protein sequence ID" value="EFX60556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX60556"/>
    <dbReference type="EnsemblMetazoa" id="EFX60556">
        <property type="protein sequence ID" value="EFX60556"/>
        <property type="gene ID" value="DAPPUDRAFT_19892"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_19892"/>
    <dbReference type="HOGENOM" id="CLU_009579_11_1_1"/>
    <dbReference type="InParanoid" id="E9I624"/>
    <dbReference type="OrthoDB" id="1327781at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F1_2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX60556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="73" mass="8501" checksum="3B6E32A33A46563A" modified="2011-04-05" version="1" fragment="single">TLGIIMSAFTLCWFPFFVLALVRPFMSHQTASLVIPRWLSSLFLWLGYANSFLNPVIYATTNKDFRLPFREIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9I692</accession>
    <name>E9I692_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_343128</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL736279">
        <property type="protein sequence ID" value="EFX60488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60488">
        <property type="protein sequence ID" value="EFX60488"/>
        <property type="gene ID" value="DAPPUDRAFT_343128"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_343128"/>
    <dbReference type="HOGENOM" id="CLU_881596_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX60488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="316" mass="36453" checksum="1D7A3511678A3888" modified="2011-04-05" version="1" fragment="single">MKVKSLSIKDFNQFKDFELDLTYPAGHPKAGLPLDKVCIIGQSGTGKTSLLVFIKMALDFLEKQDNLITLHSPLPLTRLITGQPEKTILTINNTLIKEDRIAISNQPGTRLSNLQRITHNFLQKAIFGYIYYPAYLIDSYKESDKQEILSANESEGFMAVDLSLYDAPKYWNRILEKIQKYQEVEIQKRIELSEILQNPNISLEELNQARQKFGKWFTENFNPLEDLANNFLDDILRKFNLRTRKKLSFNGKEDLGNIKIETLQGIEVPLNAWSTGTKHLIFSILPLYGIKPEKKLLLFDEPERSLYPDIQTEIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9I7M0</accession>
    <name>E9I7M0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_345868</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL737325">
        <property type="protein sequence ID" value="EFX60010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX60010"/>
    <dbReference type="EnsemblMetazoa" id="EFX60010">
        <property type="protein sequence ID" value="EFX60010"/>
        <property type="gene ID" value="DAPPUDRAFT_345868"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_345868"/>
    <dbReference type="eggNOG" id="KOG0941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046307_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9I7M0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56204"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="53"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX60010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="328" mass="38288" checksum="EFACF83C5AEF7BAD" modified="2011-04-05" version="1" fragment="single">MANMPLEEFDRIRTNMTRQEFHPKKFCIKVCRNNIXQSSFKAFKGVLRTERNTTPLLHASNFKVSFLNEEGVDTGGLSREWASLMAIQLQVSELSIFNSYKEGFYFRRDGKNKKYAKFCGAFLGLAISKELTLDCRFSDIFYYILTRDPKNIQLSFKDMKSIDTDLHRGFSNSDSNLLNDLENFYKDGDDKKKLDFFKACKRYLIVSPDEKIGAHLPRDKDGETFKSIVLTDDDLNSLRDELTHEIYYSALKDTIEPFLDGVHMFIPPEELKKISIEDLRKKVEGEFSEINDKAFEKWKAITVWKYLTNSGTEIEKETWENELKTQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRF6</accession>
    <name>E9FRF6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_94481</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90208"/>
    <dbReference type="EnsemblMetazoa" id="EFX90208">
        <property type="protein sequence ID" value="EFX90208"/>
        <property type="gene ID" value="DAPPUDRAFT_94481"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_94481"/>
    <dbReference type="eggNOG" id="KOG1801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_724147_0_0_1"/>
    <dbReference type="InParanoid" id="E9FRF6"/>
    <dbReference type="OrthoDB" id="633768at2759"/>
    <dbReference type="PhylomeDB" id="E9FRF6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
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    <sequence length="298" mass="34095" checksum="7FC3FCE8FE78E50D" modified="2011-04-05" version="1">MDDDVIFQVTSGFEDIAVYCSTYTSALPIILLLGFFTSTSMQRWFSLVTTMAGTTKVIANFVMSIKENQPEGHQIVQQYTRWILLGWALTFRLICKPLKRVFPNLTSLQNAGLLQPHETLLLEREPASNHPLVVIHWNLTLLKLCNRKGIFMDISDYGRNQDLLMGFKKSCGDTIKFASKNIPFALIQAVTITVYSFGLASLMARQLTEKHTPTSFIIKYFPVLNTFQYFLYYLWLKFGRLAAYPFGDDENDIDIKRIFQAHIEDAVRWLSLYSSPGLTDQLVSMSLHSSSNEWMINA</sequence>
</entry>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Arnold G.J."/>
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                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E69497" last="E69497">
            <title>Mitochondrial Capture Misleads about Ecological Speciation in the Daphnia pulex Complex.</title>
            <authorList>
                <person name="Markova S."/>
                <person name="Dufresne F."/>
                <person name="Manca M."/>
                <person name="Kotlik P."/>
            </authorList>
            <dbReference type="PubMed" id="23869244"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DX11_1_2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="3 7"/>
    <dbReference type="EMBL" id="KC536084">
        <property type="protein sequence ID" value="AGR85178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89380"/>
    <dbReference type="EnsemblMetazoa" id="EFX89380">
        <property type="protein sequence ID" value="EFX89380"/>
        <property type="gene ID" value="DAPPUDRAFT_230172"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230172"/>
    <dbReference type="eggNOG" id="KOG1495">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_045401_0_2_1"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="OrthoDB" id="1204514at2759"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="8">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="9">
        <location>
            <begin position="163"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
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        <ligand>
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        <location>
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        </location>
        <ligand>
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        <location>
            <position position="169"/>
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        <ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGR85178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX89380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="332" mass="35735" checksum="FDDC05006F00251C" modified="2011-04-05" version="1">MATSVDKLKTEIQTPVAHSGSKVTIVGVGQVGMACAFSIMTQGIASELTLIDVMEDKLKGELMDMQHGLAFLGNIKMTAGSDYALSAGSKLCIVTAGARQREGESRLNLVQRNADILKGMIPKLVQHSPDTLLLIVSNPVDLMTYVAWKLSGLPKERVIGSGTNLDSSRFRFLLSERFNVAPNSTHGWIIGEHGDSSVPVWSGVNVAGVRLRDLNPAAGTDADTENWGQIHTQVVQSAYEIIRLKGYTSWAIGLSVSILTKAILKNSRNVFAVSTFVQGIHGVEQPVFLSVPCVVGENGITDVIQQTLTEGERNQLQKSAATLNEVQINLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9FVF9</accession>
    <name>E9FVF9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_233683</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX88548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="56" mass="6218" checksum="F2C76410A37B83CD" modified="2011-04-05" version="1">MPVLLVLVLTCHQQQSHHHGLASQLIGEIPLLYISAVLVYTQFCACSRGLNFPPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXP4</accession>
    <name>E9FXP4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_234884</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88129">
        <property type="protein sequence ID" value="EFX88129"/>
        <property type="gene ID" value="DAPPUDRAFT_234884"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_234884"/>
    <dbReference type="HOGENOM" id="CLU_468740_0_0_1"/>
    <dbReference type="InParanoid" id="E9FXP4"/>
    <dbReference type="OrthoDB" id="722789at33208"/>
    <dbReference type="PhylomeDB" id="E9FXP4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="622" mass="70997" checksum="C9275741BDE5A2D5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXS5</accession>
    <name>E9FXS5_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_234919</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX88235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88235">
        <property type="protein sequence ID" value="EFX88235"/>
        <property type="gene ID" value="DAPPUDRAFT_234919"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_234919"/>
    <dbReference type="HOGENOM" id="CLU_1604405_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXU4</accession>
    <name>E9FXU4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88162">
        <property type="protein sequence ID" value="EFX88162"/>
        <property type="gene ID" value="DAPPUDRAFT_311759"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_311759"/>
    <dbReference type="HOGENOM" id="CLU_2348787_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX88162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="97" mass="10664" checksum="D550CA36A26D95E4" modified="2011-04-05" version="1">MFWTPESGGVTIKEKSSCTPINSHLPEDRQKTYVNQTTCAQYESFVTGETTQMLLVAQVLITSCGQWSALTFGDMLLTVRLCCCISPSSACYFHAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYH7</accession>
    <name>E9FYH7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_306512</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal</text>
            <dbReference type="Rhea" id="RHEA:55196"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:74116"/>
            <dbReference type="ChEBI" id="CHEBI:138631"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:55197"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the TPP enzyme family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX87765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87765"/>
    <dbReference type="EnsemblMetazoa" id="EFX87765">
        <property type="protein sequence ID" value="EFX87765"/>
        <property type="gene ID" value="DAPPUDRAFT_306512"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306512"/>
    <dbReference type="eggNOG" id="KOG1185">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="FQEWPQV"/>
    <dbReference type="OrthoDB" id="330201at2759"/>
    <dbReference type="PhylomeDB" id="E9FYH7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
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    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="PTHR43710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="6">
        <location>
            <begin position="190"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="7">
        <location>
            <begin position="385"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX87765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="566" mass="60827" checksum="A098D9F768708B80" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZ42</accession>
    <name>E9FZ42_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_43248</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87665"/>
    <dbReference type="EnsemblMetazoa" id="EFX87665">
        <property type="protein sequence ID" value="EFX87665"/>
        <property type="gene ID" value="DAPPUDRAFT_43248"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_43248"/>
    <dbReference type="eggNOG" id="KOG2706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011340_1_1_1"/>
    <dbReference type="InParanoid" id="E9FZ42"/>
    <dbReference type="OMA" id="EVERCWT"/>
    <dbReference type="OrthoDB" id="881262at2759"/>
    <dbReference type="PhylomeDB" id="E9FZ42"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071617">
        <property type="term" value="F:lysophospholipid acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX87665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="462" mass="53451" checksum="D052B360A379ABC4" modified="2011-04-05" version="1">MLWDDVIYLFLLLATIGLGEVLRRFDNANIKQSISTAIGFTIVFIVSGFHTLHCVLTAAVNALIIRYVSPKFCHGLSFGFSFTYILFFRFTTVFGLPEVPSHTNAIQMLLTLRMVGLALEVHETAKNNRLLKESNAADKKQDSNTDVKEVEFALEYQGVNPCFLDVFHYAYCYIGVLTGPYYKYRTYWDMLHANDTKISFFNHARYRLRYVPVYVFFFILSSYYFPLSYATTEEFFAEHSTYYRIWYMTPLFFNFRMRFYSGFILSEVACIMAGLGAYPEESQPKPGNGPTALQNFKKDRSLTTYNFETVHNIDEYSAETCDVRGSMRAWNMTVQWWLVVNVHRRFPVKPLRTVVTMLISAFWHGVHSGYYLSMLTVPFILVAEDAIKKKLRPIVSPKIFNFGMGFMKIQWFSYMGVAFSLLAMDVTLAYWKSIYFIGHLLVPVFYLACLTIPSAKPVKSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZ59</accession>
    <name>E9FZ59_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_235516</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX87655.1"/>
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    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87655">
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    </dbReference>
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        <location>
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            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX87655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="515" mass="58655" checksum="28D8C70A695B230F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9G0V8</accession>
    <name>E9G0V8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3">
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        <name type="common">Water flea</name>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2111331_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
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        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX87338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="115" mass="12771" checksum="59FD20DE199E2E36" modified="2011-04-05" version="1">MLELQKKIQELEISFQVDRAKQAVPPSGIKRQQVVIDKSISAAISTGARIRLSNVIASTGAVVVNRRRIGKITDNYQEPIGRGEFGQVFKGTWHGRKAAVKEIRSPWRCSTVIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9G174</accession>
    <name>E9G174_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_312986</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86623">
        <property type="protein sequence ID" value="EFX86623"/>
        <property type="gene ID" value="DAPPUDRAFT_312986"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312986"/>
    <dbReference type="HOGENOM" id="CLU_1898340_0_0_1"/>
    <dbReference type="OrthoDB" id="1357584at2759"/>
    <dbReference type="PhylomeDB" id="E9G174"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX86623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="165" mass="18860" checksum="EAFA0B622231F6DC" modified="2011-04-05" version="1">MSIPLEGHGDYYAKVSWSGVEVGPIPSNVNLQKERKISFTFEGHGDHYLECVMWCRGWVRMGRVASLSSRYNSRKDLEGECCLVNHGVVDGWVDHWCTDVSWVWRIPNRNAAALLLNTNVRNNRYYMTKAPGYTTSYNAPSHYTEALKFNSAPSFTTKEPEYQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9G196</accession>
    <name>E9G196_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_313009</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86679"/>
    <dbReference type="EnsemblMetazoa" id="EFX86679">
        <property type="protein sequence ID" value="EFX86679"/>
        <property type="gene ID" value="DAPPUDRAFT_313009"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_313009"/>
    <dbReference type="eggNOG" id="KOG1216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676642_0_0_1"/>
    <dbReference type="InParanoid" id="E9G196"/>
    <dbReference type="OrthoDB" id="1223914at2759"/>
    <dbReference type="PhylomeDB" id="E9G196"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004094">
        <property type="entry name" value="Antistasin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011061">
        <property type="entry name" value="Hirudin/antistatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02822">
        <property type="entry name" value="Antistasin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57262">
        <property type="entry name" value="SSF57262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51252">
        <property type="entry name" value="ANTISTASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="4">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="3">
        <location>
            <begin position="205"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX86679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="407" mass="43786" checksum="F91BEF8E24626277" modified="2011-04-05" version="1">MSLNETWMEDDCTTCICRDGQSKCQASFCRTPCLQPRKVPGECCPVCDDDCHLQCLYGRAVDSSGRELCECRKVPDEDFRDLQVTIQTKVIDRAEGVDGQEADGDFVTAGANEAINCPRVPCKRMCAHGFQTDERGCPICKCQRCKSIQPCHKKCALGLVHDGRGCPTCHCRPGVSSSTSPSQNGGATRQPVMTSSFSVSSSSNGKCLAGGSNLTFYNYGDRWQMDDCTHCVCHPGGPTCTEMACPLPCHNAIFVPGQCCPVCGDGSRTSTIPTGGSSTGQQRNSDESRDGMADGTALLTVVLVCVALVAGLILIVAILAVCVARQCQRLQLHEENMAAAAVKLTAVNRLRPKSTNLDYQYNLYLHRYRETVPGNGWPFDGSSDSQDKDEGGSSQCSNSPLLMVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9G245</accession>
    <name>E9G245_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_308482</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX86182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86182"/>
    <dbReference type="EnsemblMetazoa" id="EFX86182">
        <property type="protein sequence ID" value="EFX86182"/>
        <property type="gene ID" value="DAPPUDRAFT_308482"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_308482"/>
    <dbReference type="eggNOG" id="KOG2844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_11_4_1"/>
    <dbReference type="InParanoid" id="E9G245"/>
    <dbReference type="OMA" id="PMKHAYI"/>
    <dbReference type="OrthoDB" id="813396at2759"/>
    <dbReference type="PhylomeDB" id="E9G245"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX85560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="117" mass="13389" checksum="44DA4B109E4C89F9" modified="2011-04-05" version="1">MELHPGVITGMTKFLASATPVVNLRWIYLLDPNCYPDLLLITSSRRHHQNDEILGIPHSSRWMDGLPSRPQYPFCQNTVVLFELFSLLHHNTQGGRDVPGVVRFGRFLSLNNTYDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9G4V2</accession>
    <name>E9G4V2_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_222617</name>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85364">
        <property type="protein sequence ID" value="EFX85364"/>
        <property type="gene ID" value="DAPPUDRAFT_222617"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_222617"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_2_1_1"/>
    <dbReference type="InParanoid" id="E9G4V2"/>
    <dbReference type="OMA" id="CLAKQTQ"/>
    <dbReference type="OrthoDB" id="1031056at2759"/>
    <dbReference type="PhylomeDB" id="E9G4V2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
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        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="10"/>
            <end position="180"/>
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    </feature>
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        <location>
            <begin position="199"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX85364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="325" mass="37241" checksum="9CAE8C52A871F86B" modified="2011-04-05" version="1">MDLNQFNEKQKAVLKQFREALNDCQLPDSEDVYLIRWLIARDFDLAKAEKMLRNSIEWRRKFKIDALREELKEPEVLSKYFPAGFVGRDKSFNPSMESAIKLIQVYEANYPEYLHRVFVINAPTIFAIGFSMIKPFLNERTRNKIQIFNHDIKQWKAALLTEIDAEELPACYGGKKTDPDGNPNCATLASPVNMGGVVPKSYYFSGKSDTTNKTPLTVANGSKEHVEFQVKRAGDVLKWDFHTEEGDIAFALYKKQDGELIPIVHFDRVDCDMSTEEGELQCDDTGVYVVEFDNNFSYLRSKKIWYSIKVESATARVNGTDLDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9G5E1</accession>
    <name>E9G5E1_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_237625</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX85649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85649">
        <property type="protein sequence ID" value="EFX85649"/>
        <property type="gene ID" value="DAPPUDRAFT_237625"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_237625"/>
    <dbReference type="HOGENOM" id="CLU_1373481_0_0_1"/>
    <dbReference type="InParanoid" id="E9G5E1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX85649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="216" mass="24861" checksum="53AA50291E280531" modified="2011-04-05" version="1">METATSPPNYITTYATTSYYTEAHKYYSDPSYYTDAPAYYITEPHKYYTSKAPEYYTTTYAAPAYAAPAYYTEAPKHYTTRESEYYATTYAPSAYYTETPKYYFAPAYYTEALNTTLHPATYPQLRRPTAAPSYYVDPNYYEVPDYYTKSTLPPFTTLKLLFTATPRHPSITLAAATYCTKAAKYSTTPSYYTIKATECYITTFASPVYNREALKY</sequence>
</entry>
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    <accession>E9G5P0</accession>
    <name>E9G5P0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    <gene>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732532">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX85596"/>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_313917"/>
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    <dbReference type="Proteomes" id="UP000000305">
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236691" evidence="2">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX85596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="109" mass="12439" checksum="AF69B33FC7D600D8" modified="2011-04-05" version="1">MKFLPIFVLVAVCFAVVVEAKPLLANGIERAERAVTDKPKTEKPKTEKTEKPKTEKTEKPKTEKPKTEKTEKPKTEKPKTEKTEKPKTEKPKTEKTEKPKTEKPKTVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9G669</accession>
    <name>E9G669_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Zdobnov E.M."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83658"/>
    <dbReference type="EnsemblMetazoa" id="EFX83658">
        <property type="protein sequence ID" value="EFX83658"/>
        <property type="gene ID" value="DAPPUDRAFT_47739"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_47739"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013173_19_0_1"/>
    <dbReference type="InParanoid" id="E9GA03"/>
    <dbReference type="OMA" id="SFWSDND"/>
    <dbReference type="OrthoDB" id="1344250at2759"/>
    <dbReference type="PhylomeDB" id="E9GA03"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051019">
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    </dbReference>
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        <property type="term" value="P:peptidyl-threonine dephosphorylation"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX83658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="304" mass="34030" checksum="EDCB4E61679121B0" modified="2011-04-05" version="1" fragment="single">MEDVFSVAYQHTKEGQDLEYAYFGIFDGHGGKHAAIFAKEHLMDNIVSNPYFWSENDEDVLKAIKEGFLTTHQAMFKVLETWPKTMSGLPSTSGTTASIAFIRRGKIFTGHVGDSGIVLGYQDPDSNVWLARPLTQDHKPESAMEIGRIQEAGGKVVWKAGVPRVVWNRPKIGHQGPVLRSTHIDEIPFLAVARSLGDLWSFNSASNQFVVSPEPDVNTMTIDVSRHRCLILGTDGLWNMIPPQRAVEVVQHIDRQNKTQPNPDQQPLPWTNPSKRLVNTALDYWMMNKLRADNCTAVTALLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBI9</accession>
    <name>E9GBI9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_223527</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732538">
        <property type="protein sequence ID" value="EFX83144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83144"/>
    <dbReference type="EnsemblMetazoa" id="EFX83144">
        <property type="protein sequence ID" value="EFX83144"/>
        <property type="gene ID" value="DAPPUDRAFT_223527"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_223527"/>
    <dbReference type="eggNOG" id="KOG4430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_950791_0_0_1"/>
    <dbReference type="InParanoid" id="E9GBI9"/>
    <dbReference type="OrthoDB" id="1091784at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX83144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="293" mass="32868" checksum="7170DADDBFB92E7D" modified="2011-04-05" version="1">MAEGISGQLYQFPPESYVDPCTICLGEREDRSLPNNCFHEFCFSCLLQWSEVKPVCPLCVQPFSSIIHNIKSDHEYDEQRIEMADPALDFEYSMNYDEIVFSPDLSLYNGRSIFDQLYISEQPTSTSQVNVSHAPTRVFMVVGEELGMITRSGASSWPAVTESSSEDNLHTTFTQQPVTSEQSLENLDRFPSSLQSDLVASHDSGSSLPPRPSRIGRVSLAIDEGERIVGRGLHCKISNRRCLPDPRPSAPTVGRRRTEEEVGNLELEEEEGGNFESDEEEGVHFQLEIDPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDH9</accession>
    <name>E9GDH9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_101475</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX82473"/>
    <dbReference type="EnsemblMetazoa" id="EFX82473">
        <property type="protein sequence ID" value="EFX82473"/>
        <property type="gene ID" value="DAPPUDRAFT_101475"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_101475"/>
    <dbReference type="eggNOG" id="KOG3516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029491_0_0_1"/>
    <dbReference type="InParanoid" id="E9GDH9"/>
    <dbReference type="PhylomeDB" id="E9GDH9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="C1Q"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241108" description="C1q domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="3">
        <location>
            <begin position="351"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX82473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="496" mass="54500" checksum="01D8F309E86C77A4" modified="2011-04-05" version="1">MSRFSRIHLSFVLFFCSTCLTAGFSVEEQLHQLRENYVELKHNLELKVVQLEAKVVQLEEKVQHQESILIALQSQQPINSKSVSAISQPSGKIYVLRTCRETRAADPSLGSGMYWIDPDGQGVGDDPIYVFCNMATGSTKISHNTESKTDVGNCADPGCYSKAINYNATMRQIMALVDLSTECHQSIKYDCISAPLEINGIVYSWWNDRNGNPQYFWSGSNSSVHVCQCGLDRNCVESPAVPCNCDSGLPTLLADSGVITVKNLLPITRLNFGRTILEGSSGQYTLGRLECSGQMAVTGMPKSCEDLWWIGHTLSGLYSVMGTAMVENVYCDFTKLPSDAGFQKWMGFADVQSVPTYFLVTKDNGFSSMNISIPYTTEKLNIGGAMDLSSGKFTAPRTGTYFFSFTGLISFPTSSSTVLELGVGIYLNGVEIGRSWDDEANTVIGQEVPVVVQSTVNLQARDQVWMQITAITGGVTMHSVRSFTGWLLQENLSQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDX7</accession>
    <name>E9GDX7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_241304</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82164">
        <property type="protein sequence ID" value="EFX82164"/>
        <property type="gene ID" value="DAPPUDRAFT_241304"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241304"/>
    <dbReference type="HOGENOM" id="CLU_866724_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GDX7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240245" evidence="2">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX82164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="321" mass="35429" checksum="6632CDFFB49BA52B" modified="2011-04-05" version="1">MKSILISIVILMMWIDPSVCIWGKAKSSSNNNKAVMSSGEIPAEHRSGKSSDDMFVMLDDQAAEYEGSIEGGETLISNGTTEEEERLFNKFPLHVFLKKKHPFVTLSTMTKTSTVTAVITSSTVGLCAQLVNVTGPCRLRKGLWVDEPIVLSFDDEMDSIDDTLLSPSQTSKMETTAVPEPIAQISDEIAGRNDESQILDNNRRISVRSGSVIHSSKNDEESRDNSEQVNEGRFGFFGLKNKLKKKVKLVTVVTTTAVTVTSTSTYYKTVSTKSFFIQVCTPSPFPFNVCDGRKKRQVEIESPSWPSIKSQIKIIVATITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEI3</accession>
    <name>E9GEI3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_316969</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82308">
        <property type="protein sequence ID" value="EFX82308"/>
        <property type="gene ID" value="DAPPUDRAFT_316969"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_316969"/>
    <dbReference type="HOGENOM" id="CLU_3089328_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX82308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="52" mass="5796" checksum="67C89205BE98DDB6" modified="2011-04-05" version="1">MAVNEDELRAGPFGIVTHTREGLEFGMFNVVLHRASNRLNPAMEVADPDRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEP8</accession>
    <name>E9GEP8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_317026</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732541">
        <property type="protein sequence ID" value="EFX81873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81873"/>
    <dbReference type="EnsemblMetazoa" id="EFX81873">
        <property type="protein sequence ID" value="EFX81873"/>
        <property type="gene ID" value="DAPPUDRAFT_317026"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_317026"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_8_1_1"/>
    <dbReference type="InParanoid" id="E9GEP8"/>
    <dbReference type="OMA" id="LEERNCC"/>
    <dbReference type="OrthoDB" id="454773at2759"/>
    <dbReference type="PhylomeDB" id="E9GEP8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
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        <location>
            <begin position="23"/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
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</entry>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wolf Y.I."/>
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                <person name="Shaw J.R."/>
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                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="352" mass="39303" checksum="4517AA54B7B35FF3" modified="2011-04-05" version="1">MSKPRWTRIPPCAAHKKLEKMFEYSKIANDANASSVWHLDSEFQKFKLDVFRTAFNEIRNKHGCELRKEDGSSSSADHGSDTCSNIVPSKRFKLEFESDAIADEESLDSHLEFQNHPILMEVYLDHVTQNKKLIIVAYLPGGATEGDFNLLGAGLGSNIARITYKWPEACYNIDRLFRKSIASGALPDCHPKIVALKRGLQRNRASMSKAPVGVISLNLPISVLTSESSIDVKGGLDKENGTSQGSKKYHTTLSSGRALVAAPVWVLSYINRIFGGTDPSHCHYPLYAGGAVSLRALEVQARPPLLPEATRSHVPRNQRSWHRRVAYTSRLQGWEECKESKIIEEVCLPRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GHX5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">DAPPUDRAFT_318117</name>
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    <organism evidence="3">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX80912"/>
        <property type="gene ID" value="DAPPUDRAFT_318117"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_318117"/>
    <dbReference type="HOGENOM" id="CLU_2123532_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237479" evidence="1">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="93" mass="10897" checksum="5ED547A266E1F71A" modified="2011-04-05" version="1">MNVIFVITSVVAVVAGQVPYQKPTDYVPYQLLNDYKPSYPAPNYKLTSPKSYKPAAYHEYKQTYNEPTYKPEPSYKPYDYPPKYTPYSYSVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJZ9</accession>
    <name>E9GJZ9_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_103726</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732548">
        <property type="protein sequence ID" value="EFX80209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80209">
        <property type="protein sequence ID" value="EFX80209"/>
        <property type="gene ID" value="DAPPUDRAFT_103726"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_103726"/>
    <dbReference type="HOGENOM" id="CLU_052726_1_0_1"/>
    <dbReference type="InParanoid" id="E9GJZ9"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="PhylomeDB" id="E9GJZ9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="278" mass="30223" checksum="3836559795700F33" modified="2011-04-05" version="1">MFADGKSLWEVLSAIRSTPISGILQSPSVLLQGWNFRGNLPFLPSELTPRLVPASAVTSELCRRQAKAVFDTPRRTDARSSVLHVGQRVRTLVGKKWRPGVIQAVCKEPHSYFIRLSDGRLFRRTRWAVNIDRGVANAVDTGPWTSVGTNDTNPITSSGQQPIAPSSVTVRRPFQPQNSRAVEVPPACPTPARAAVLRVNTPAPPTPVSSHVSLQGAQQYSSGRRSSSWQDEGPSRAVPVRLFPSVQPAATEEQPGSSDPVQNVVVFVRTVWHNAVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKK3</accession>
    <name>E9GKK3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_103861</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732549">
        <property type="protein sequence ID" value="EFX80049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80049">
        <property type="protein sequence ID" value="EFX80049"/>
        <property type="gene ID" value="DAPPUDRAFT_103861"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_103861"/>
    <dbReference type="HOGENOM" id="CLU_635031_0_0_1"/>
    <dbReference type="InParanoid" id="E9GKK3"/>
    <dbReference type="OrthoDB" id="1777782at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="432" mass="48215" checksum="B21E0B278ACD11E1" modified="2011-04-05" version="1">MASSVVNNGTQHWYPNILGERASVKRKTPQPDWILYQCKIRGTSDSYEASRAKENLAGVQPDINSASESQTQHNMGKGHRNRRPRKQFAVDESHDSSSDASTVGMYGPTQFDTHLIPPELYENAVRTARQVANNVPMLLKALESHQSTSLFNVNSPSSTAGSSSVVRRETGERDQVFVAQPTNTEGFEKIVKKLVWETLKQNKTLTNLMDKLVRMIRSLGGASVSNCLQQALKSVFSIKVMAQANWEGKTKKESIQKHGLQHSIISTAGFAHNVYFSAANNIDCSAANTVDCSAANTIDCSAANTVDYSAANTTRITQGSSLLIYLFQWLAFDEYHLRQYLRTVLDKIKPPMDVHFQINWMFVFGRQLDVRFRTSNGRRSTERISGRSRIIRITSSSDVQIFISKGRATINGSKSLETRCRSVLKSDYFAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9GL75</accession>
    <name>E9GL75_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">c-SKI_SMAD_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_26062</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKI family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732550">
        <property type="protein sequence ID" value="EFX79843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79843"/>
    <dbReference type="EnsemblMetazoa" id="EFX79843">
        <property type="protein sequence ID" value="EFX79843"/>
        <property type="gene ID" value="DAPPUDRAFT_26062"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_26062"/>
    <dbReference type="eggNOG" id="ENOG502QTF6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030459_0_2_1"/>
    <dbReference type="InParanoid" id="E9GL75"/>
    <dbReference type="OMA" id="DLHHECS"/>
    <dbReference type="OrthoDB" id="1031382at2759"/>
    <dbReference type="PhylomeDB" id="E9GL75"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014890">
        <property type="entry name" value="c-SKI_SMAD4-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003380">
        <property type="entry name" value="SKI/SNO/DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037000">
        <property type="entry name" value="Ski_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023216">
        <property type="entry name" value="Tscrpt_reg_SKI_SnoN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005">
        <property type="entry name" value="PTHR10005"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="157"/>
            <end position="252"/>
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            <begin position="1"/>
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            <begin position="1"/>
            <end position="17"/>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SMART" id="SM01046"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="255" mass="28380" checksum="FF0F6DD7ACA56049" modified="2011-04-05" version="1" fragment="single">LLLPSSPQQQQPATVQPAPLLPSFPILSAADRGWSHAERNETQLEGQPIACFTVGGEPRLCLPQILNSVLRQFYVMQIHAVCDELQINCSRCTAEQLDSLKAAPAILPRSAASCGLITKTDAQRLCSALLRRGLNEARGDNTTRCSSKNNSSSNAWFRVYHQCFGKCEGLCKPELYTSPDAMCIECADCSLTLSPADFISHAHRSVENRTCHWGFDSTNWRAYLLLARRQQQPQPSNEVLLHQLDEFKNRFGFSS</sequence>
</entry>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX79262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_52627"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG1922">
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    <dbReference type="PhylomeDB" id="E9GMN6"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="256" mass="29397" checksum="0FE8DE0CE8DADBD3" modified="2011-04-05" version="1">MFDFLEKFEEWDPELSIQLLKIPSLPNYSGFRKLIENAKSSWMEDFLERDGLAVLFDRLEKLSTGFSITNALFQSEVTYAIRAVVNSKIGLEYLLAHRQFTRQLFNAMATKNTLVKKLVLELFSAVCVYSTLGHEATLDAIDYFKMSRTDVHRCSILISEINASDTIEYKAAILGFANSLILGTAKIWTRHAIRSEMIGLGLLEVIENMKMTDNPELAIQIQVFELHRIKDEDSLDATEEKSLFDLFSLYFIKVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GN27</accession>
    <name>E9GN27_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3">
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        <name type="common">Water flea</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX78962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_319870"/>
    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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            <end position="147"/>
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    </feature>
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            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="192" mass="21103" checksum="60988F5B95271CC0" modified="2011-04-05" version="1">MEETNSLAVSWSDTSSTPTTNAGRKQQATTSSPKICVQRDAHVDRSFHEGQSSIVSERSCSYDSQESSHFLADQESDSRCYSPSRKPSFGSIGSDSCTDNNMDSRTSIKPTRSSHHNSLSRSSSSRSTFLSVPTRVPNHLWLSSTSDHQTDHNKEQHGQSSANSQQGSTSSLMASHFSLSKYDVIEPFELCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9GN74</accession>
    <name>E9GN74_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_225274</name>
        <name evidence="3" type="ORF">DAPPUDRAFT_305033</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX79083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX79084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX79083"/>
        <property type="gene ID" value="DAPPUDRAFT_225274"/>
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    <dbReference type="EnsemblMetazoa" id="EFX79084">
        <property type="protein sequence ID" value="EFX79084"/>
        <property type="gene ID" value="DAPPUDRAFT_305033"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="AB_hydrolase"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010831035" evidence="1">
        <location>
            <begin position="29"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX79083.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX79084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="480" mass="53840" checksum="12B416DFB002D6F7" modified="2011-04-05" version="1">MESKLVVKAIAVVIVACFYSTGHRCVEGQVERSYIRSNLTLRIVVRYPESELINRSLSTDLYIIGNGLGLAWGDLKLLERPGPVDTWSIDLKFSGFLDGYACSECIHNNTLPVNGRLEYRILTSNRTDMVGPNHGTAVHISKLEANFPIREHFSYPYFFSRQGSVRATSVKSLISTVIDNRIWGYYLPPSYSENSYKTYKTFLVPDLSAVYMELYRFSFDDIFAEKAIAEEAVLIGSNDYSLSNVSDGRVAFLTPTPGIQYYCYNGDWSDNCAGCIPANVSGREYMEYFRDGCGYPVEVGGLGDDYVNYMVNEVLPAIQLLTNDRLRIFRDDLGIGGCSLGGLLACHAIWTRPNTFGMGWCKSSSFWWPTEINVDNGFYFLNHTIKETNLGSRPPQRIYMDVGELEEDPYYAQVSAALSVADTMMANSPQFRMDETLWFTLASGQAHSSYNCMSRTWNSLSLLSPPAGAARSPNFPIQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9GNG0</accession>
    <name>E9GNG0_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_104822</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732554">
        <property type="protein sequence ID" value="EFX79024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79024">
        <property type="protein sequence ID" value="EFX79024"/>
        <property type="gene ID" value="DAPPUDRAFT_104822"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_104822"/>
    <dbReference type="HOGENOM" id="CLU_1373474_0_0_1"/>
    <dbReference type="OrthoDB" id="1424042at2759"/>
    <dbReference type="PhylomeDB" id="E9GNG0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX79024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="199" mass="21767" checksum="5937E37CAE2F27AF" modified="2011-04-05" version="1">MEEEEGRQSLPLNIDMVVGQVVHGSDGDNRSSPLDELLETVEVMIGAGNNNAGDEFATPVSILNGPFQAALLSLLVLMSIGANACVINNIRHNCIKLRSTHFILIQHLCMADLIGASLILPAPLVTSFRGRWEGGPNLCHLSSVVNVSLWLQHVFMFLMLKVHIQQQTAKSISRKPSTCMRYIDYTAIDTSSRSILVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9GSA1</accession>
    <name>E9GSA1_DAPPU</name>
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        <recommendedName>
            <fullName evidence="1">BAG family molecular chaperone regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_321206</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732561">
        <property type="protein sequence ID" value="EFX77677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77677"/>
    <dbReference type="EnsemblMetazoa" id="EFX77677">
        <property type="protein sequence ID" value="EFX77677"/>
        <property type="gene ID" value="DAPPUDRAFT_321206"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_321206"/>
    <dbReference type="eggNOG" id="ENOG502TB75">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055378_1_0_1"/>
    <dbReference type="InParanoid" id="E9GSA1"/>
    <dbReference type="OMA" id="AGFKMLM"/>
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    <dbReference type="PhylomeDB" id="E9GSA1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:chaperone binding"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017093">
        <property type="entry name" value="BAG-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039773">
        <property type="entry name" value="BAG_chaperone_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329">
        <property type="entry name" value="PTHR12329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329:SF16">
        <property type="entry name" value="PTHR12329:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="SSF63491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="4">
        <location>
            <begin position="107"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX77677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="197" mass="22332" checksum="AAE03578AA2852CB" modified="2011-04-05" version="1">MSNGNVLIVLGKNGSKKFELQVTFQTTVGELCAEIEKETDIPVNCQRIIYNGRALNNHAEDMQKDLHNLGLKSPAKVLVLGKKPDEEDENYKLMKKWEISCDSVTNQVSSIEKDILEMERGFAPKELFDNLPKVEKKINCLAEELMKILISLDALSFKEDQKVARAKRKCIIDKIHSLHKKCDEMVASVKQLQSTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9GSL8</accession>
    <name>E9GSL8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_54228</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
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                <person name="Casola C."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX77202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77202">
        <property type="protein sequence ID" value="EFX77202"/>
        <property type="gene ID" value="DAPPUDRAFT_106329"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_106329"/>
    <dbReference type="HOGENOM" id="CLU_1662576_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="159" mass="18010" checksum="60F66267BC33C2DA" modified="2011-04-05" version="1">MKAALLVIVKCLLRKAIPLLRGIKEQRRDVYRGATALDASKRRVIIWTGSSSGERRRDRDRDGKSPSAQSLFDRFQRRRTSVYSIHFSAVCMYRLPLRIADIQDSSRAGRERVGSVRPQRRRANVSSSLGNAANSGVSCSLGRFAHQHDRTVARENRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GU70</accession>
    <name>E9GU70_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_248334</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732565">
        <property type="protein sequence ID" value="EFX77023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77023">
        <property type="protein sequence ID" value="EFX77023"/>
        <property type="gene ID" value="DAPPUDRAFT_248334"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_248334"/>
    <dbReference type="HOGENOM" id="CLU_3016314_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX77023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="56" mass="6429" checksum="2DA25966829B4F65" modified="2011-04-05" version="1">MIQIIDVKHIDDTNYKQGSKLQILSLGAVDKTYNSMCELKQCIHYPMKQIAMTSHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GUK1</accession>
    <name>E9GUK1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_248392</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732566">
        <property type="protein sequence ID" value="EFX76737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76737">
        <property type="protein sequence ID" value="EFX76737"/>
        <property type="gene ID" value="DAPPUDRAFT_248392"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_248392"/>
    <dbReference type="HOGENOM" id="CLU_2308829_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="100" mass="10942" checksum="52DA474D1867C0FE" modified="2011-04-05" version="1">MQSDTPEVNPDVPSTVPLTNPTNDVVQTPQPPTKEPPKPAPTARIPSPSPPCYYPPNTSKTFVKQEPDDGVPVVKQEPDDGVPAERRTWLIGSRHHVETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9GW87</accession>
    <name>E9GW87_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_214082</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="GL732569">
        <property type="protein sequence ID" value="EFX76305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76305"/>
    <dbReference type="EnsemblMetazoa" id="EFX76305">
        <property type="protein sequence ID" value="EFX76305"/>
        <property type="gene ID" value="DAPPUDRAFT_214082"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_214082"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048483_0_1_1"/>
    <dbReference type="InParanoid" id="E9GW87"/>
    <dbReference type="OMA" id="VPITCIF"/>
    <dbReference type="OrthoDB" id="1094172at2759"/>
    <dbReference type="PhylomeDB" id="E9GW87"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030176">
        <property type="term" value="C:integral component of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102756">
        <property type="term" value="F:very-long-chain 3-ketoacyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
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        <property type="entry name" value="PTHR11157"/>
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        <source>
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        </source>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
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</entry>
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        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
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        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <begin position="12"/>
            <end position="32"/>
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            <end position="258"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX75984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="258" mass="29310" checksum="1715086AB79DB236" modified="2011-04-05" version="1">MSASRQWRYRMFLGLMIVYMATACIVACALLWTTVTQYKVENISDTTENQFLVPICGIKKDLYSDPHMNCDLLDHLSYEKFVANGWTKIVYSAKLNNQPIAIKTVNLKGKDITDCAKTKSILLCHNRAAEKLVKEINLLKELKHETIIQMKHYCAKTSEDNLCMKYAVIATELGDPLTNLKLLQMTWDQRRKIIQDLANLVNYAQHSPVGVLGLADLRRPQFVLINGNMKLTDLDDIIVGEPRCVTNADCSSTVFYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYI5</accession>
    <name>E9GYI5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_306755</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Diplostraca</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX75476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75476"/>
    <dbReference type="EnsemblMetazoa" id="EFX75476">
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        <property type="gene ID" value="DAPPUDRAFT_306755"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306755"/>
    <dbReference type="eggNOG" id="KOG1729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064864_1_0_1"/>
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    <dbReference type="OrthoDB" id="1237900at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008333">
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037871">
        <property type="entry name" value="PH_Phafin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="35"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX75476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="261" mass="28835" checksum="171D5CA1852C926E" modified="2011-04-05" version="1">MVDKLVNSEANARRIAMVEGCFGSSGHPLGIPGRVLVGEGVLTKMCRKKPKARQFFLFNDTLVYGNIVISKKKYNKQHIIPLEEIKLQSLEDDGPYRNGWLICTASKSFAVYAATATEKAEWIAHINKCVEDLLRKSGKKPLGEHAAVWVPDAEANVCMHCNKSQFNVLNRRHHCRKCGAVVCGPCSNKKFLLPVQSAKPLRVCLTCHDVLTKTKNNGGPNVSLNGDLSMDSSGEDDDDDDEDPENLSSSNEAKFYGEIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9H150</accession>
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            <fullName evidence="4">Uncharacterized protein</fullName>
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        <name evidence="4" type="ORF">DAPPUDRAFT_108774</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX74572.1"/>
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    <dbReference type="PhylomeDB" id="E9H150"/>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="629" mass="71541" checksum="BB43D9D2188A4753" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9H276</accession>
    <name>E9H276_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
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                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX74119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="932" mass="104241" checksum="5C8FBEA106771A3D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2G3</accession>
    <name>E9H2G3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_109260</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732586">
        <property type="protein sequence ID" value="EFX74075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74075">
        <property type="protein sequence ID" value="EFX74075"/>
        <property type="gene ID" value="DAPPUDRAFT_109260"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_109260"/>
    <dbReference type="HOGENOM" id="CLU_052726_0_0_1"/>
    <dbReference type="InParanoid" id="E9H2G3"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="PhylomeDB" id="E9H2G3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="428" mass="44749" checksum="59C19B13A6A637B3" modified="2011-04-05" version="1">MFTDGRTLWEALAAIRSTPISSELPSPAVLLQGRHLRGSLPFLQDRLVPQFIPAKFVHGQLQRRQATACFNHGGRPDVRGSALIIGQRARAFINGLCEPDSYVVRLADGRAFRRTRRDINLDNSPSAGLAVGQQSGGASVIPSAVRGYRPAPANHLLPALSWSPPGLPARAVNVPVAQPLPAALGQPSLMPQPPPVVVNPAPGPATPARPRAAPVSTDKRAIVQLPAAQSTLTASSQLAVAPHRPGSTRSVALTSSRLNCAVEAVCSEPDSYVVWLADGRAFRRTRRDINLDNSPSARLAVGQQSGGASVIPSAVRGYRPAPANHLLPALSWSPPGLPARAVNVPVAQPLPAALGQPSLMPQPPPVVVNPAPGPATPARPRAAPVSTDKRATVQLPAAQPPLTASSQLAVAPRRPGSTRSGRPYLKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2T8</accession>
    <name>E9H2T8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="3">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_200348</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="3"/>
    <dbReference type="EMBL" id="GL732587">
        <property type="protein sequence ID" value="EFX73952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX73952"/>
    <dbReference type="EnsemblMetazoa" id="EFX73952">
        <property type="protein sequence ID" value="EFX73952"/>
        <property type="gene ID" value="DAPPUDRAFT_200348"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_200348"/>
    <dbReference type="eggNOG" id="KOG2840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_1_2_1"/>
    <dbReference type="InParanoid" id="E9H2T8"/>
    <dbReference type="OMA" id="MNLDQKQ"/>
    <dbReference type="OrthoDB" id="860739at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="PTHR11807:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="4">
        <location>
            <begin position="53"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="zn-ribbon_14" evidence="5">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX73952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="341" mass="37833" checksum="6D0C9B9DF841B053" modified="2011-04-05" version="1">MVVFCSTGCGSTAVLKRPKTDDALCKNCFFWAFETEVHHTITSTKMFQPGQLVAIGASGGKDSTVLAYVLKHLNEKYNYGLKLVLLSIDEGITGYRDDSLESVKRNQEEYNIPLTVLSYKDLYGWTMDDIVKQVGRKNNCTFCGVFRRQALDRGAVLLKCDIIATGHNADDVAETILMNLLRGDIARLQRCTFHITGSDGSLPRVKPFKYAYEKEIVLYAYFKKLDYFATECVYAPDAYRGHARALVKDLEALRSTSIIDIIHAGEQLAIKDGVKLPKQGLCSSCGYVSSNIICKACVLLEGLNRGRPKLAIGKSNKALAELLAERLQNAASIKTTIQDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2X7</accession>
    <name>E9H2X7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_324855</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 6">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732592">
        <property type="protein sequence ID" value="EFX73236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX73236"/>
    <dbReference type="EnsemblMetazoa" id="EFX73236">
        <property type="protein sequence ID" value="EFX73236"/>
        <property type="gene ID" value="DAPPUDRAFT_307936"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307936"/>
    <dbReference type="eggNOG" id="KOG3403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109098_0_1_1"/>
    <dbReference type="InParanoid" id="E9H4Z9"/>
    <dbReference type="OMA" id="REGDSIC"/>
    <dbReference type="OrthoDB" id="1426335at2759"/>
    <dbReference type="PhylomeDB" id="E9H4Z9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="PTHR21668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="8">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX73236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="147" mass="16609" checksum="4B3E633FEDB4C792" modified="2011-04-05" version="1">MPKNKGKGGKNRRRGKNENEAEKRELIFKEDGQEYAQVTKMLGNGRLEALCFDGTKRLCHIRGKLRKKVWINQGDIILVGLRDYQDAKADVILKYNADEARNLKTYGEIPETVKVTDTVNFVDDGLDDDIEFGDDSGSGEDDDINDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6X0</accession>
    <name>E9H6X0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aurora kinase</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_308251</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="GL732599">
        <property type="protein sequence ID" value="EFX72472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72472"/>
    <dbReference type="EnsemblMetazoa" id="EFX72472">
        <property type="protein sequence ID" value="EFX72472"/>
        <property type="gene ID" value="DAPPUDRAFT_308251"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_308251"/>
    <dbReference type="eggNOG" id="KOG0580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="E9H6X0"/>
    <dbReference type="OMA" id="EKEGMEH"/>
    <dbReference type="OrthoDB" id="954262at2759"/>
    <dbReference type="PhylomeDB" id="E9H6X0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031616">
        <property type="term" value="C:spindle pole centrosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035174">
        <property type="term" value="F:histone serine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="PTHR24350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX72472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="304" mass="35528" checksum="0AFBA9F388811E19" modified="2011-04-05" version="1">METKQPLKENSTNQPTVKLENSEWSLDNFEIGRPLGKGKFGNVYLAREINTKYIVALKVLFKSQLQKCQMEHQLRREIEIQSHLRHPNVLRMYGYFYDETRIYLILEFAGNGEMYKYLKRQPNGRFSEPQTANYMAQLADALMYCHARKVIHRDIKPENLLLGIRGEIKIADFGWSVHAPSSRRTTMCGTLDYLAPEMVEGRSHDERVDLWTLGILCYEFLVGSPPFEEEKQDLTYRRICKVDLKFPAHLSTGAKDLITKLLKSRAEDRIPLRKLLEHSWILQHLSDEVRSRLPTFQIMQPNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HA54</accession>
    <name>E9HA54_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_111797</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX70744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70744">
        <property type="protein sequence ID" value="EFX70744"/>
        <property type="gene ID" value="DAPPUDRAFT_327866"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_327866"/>
    <dbReference type="HOGENOM" id="CLU_2443091_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="90" mass="10292" checksum="EACFEADA03022F0B" modified="2011-04-05" version="1">MAIPSDTDWEEDVEALKPVKTQLRSLFIPTDFESLKFLAFHSTTPDEIMRPLSGNSRAQQEIGITNTTIQQYLQMTFYTTQTALSSILYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HC22</accession>
    <name>E9HC22_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Post-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_309316</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732618">
        <property type="protein sequence ID" value="EFX70691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70691">
        <property type="protein sequence ID" value="EFX70691"/>
        <property type="gene ID" value="DAPPUDRAFT_309316"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309316"/>
    <dbReference type="HOGENOM" id="CLU_600300_0_0_1"/>
    <dbReference type="OrthoDB" id="9204at6657"/>
    <dbReference type="PhylomeDB" id="E9HC22"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Post-SET" evidence="1">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="456" mass="52627" checksum="7929BC4B3FCAAD72" modified="2011-04-05" version="1">MSLAIFASPKLVRILDPNSNPIDVWVDEFSFCLAQYLCEQEAQNESNQQVNEICPSEYYSSADYIPDANEENLECQCFPDVIQHEPLQNCLFELEEDTPAMSPVNYNPNTVYVLQSPHMALFQQDTAMCVHANLSLSNSYCMNSLPFHPQTTHLYEPQHWTVPQIPETSYEIYPESLTFNQPAESYDPHPYFPDTPFLPVGIHEEDDFQGFPLNAENDSMPENFMMYTAENGSFFIENKLSEISAFAYNNLTNWGFSHPMGHVLKNKRGLFGCFTLHSGKACYVKFTPYSIKFSSNQRGVAYVIDEAGVRTCWESFKSFEELISERDHKWENFDRHQVIMQRPCGCGASSCSHHMSSKELWNSKSEENICIERNGLRFYSETSELKSLNIDLETYQLSSTLKHVGEQDGHIYVKSCQYRFIQSVFFNAFLIPLGDSLRLHFLQYFARQFMNPHSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDX3</accession>
    <name>E9HDX3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phtf-FEM1B_bdg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_8633</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732626">
        <property type="protein sequence ID" value="EFX70058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70058"/>
    <dbReference type="EnsemblMetazoa" id="EFX70058">
        <property type="protein sequence ID" value="EFX70058"/>
        <property type="gene ID" value="DAPPUDRAFT_8633"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_8633"/>
    <dbReference type="eggNOG" id="ENOG502QQGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2242602_0_0_1"/>
    <dbReference type="InParanoid" id="E9HDX3"/>
    <dbReference type="OMA" id="DKQLWEQ"/>
    <dbReference type="OrthoDB" id="1615632at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039775">
        <property type="entry name" value="PHTF1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021980">
        <property type="entry name" value="PHTF1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12680">
        <property type="entry name" value="PTHR12680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12129">
        <property type="entry name" value="Phtf-FEM1B_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Phtf-FEM1B_bdg" evidence="6">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX70058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="98" mass="11498" checksum="587A44718AAB7797" modified="2011-04-05" version="1" fragment="single">ALCWYQHKIGAYDKQIWEETVEQRILHGLSHVPKKSGKLKLDYIDLDVVRGSSFPKAKPKHGLVYLSQLCVLRLLFLPFHRHWWIQQTSCGVFQLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HH31</accession>
    <name>E9HH31_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_228845</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732645">
        <property type="protein sequence ID" value="EFX68953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68953">
        <property type="protein sequence ID" value="EFX68953"/>
        <property type="gene ID" value="DAPPUDRAFT_228845"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_228845"/>
    <dbReference type="HOGENOM" id="CLU_2135955_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Tsuchiya D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Crease T.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330463"/>
    <dbReference type="HOGENOM" id="CLU_1103725_0_0_1"/>
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    <proteinExistence type="predicted"/>
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            <begin position="51"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="252" mass="28194" checksum="C742DD4045849ED4" modified="2011-04-05" version="1">MFKKGLISPDALPHKTFELDREFMEFSLPVFRGVFNELKCKYGLGLEANQSGASGVSGSSAYVSGSTTKRSRPSDPENVSEEEDMDANVVSKNQPVLMSVYKDPDTEEEKLCVLVTMPGGVSHVKFEVVGTGPGSNVAKVTYDWPPISNYIRSIKLFGVNKWVDQTAATRVMLYEVDHEVDHMVGKEVDRKSEDLEVQLPDHAKQLLHKEEEEDCTNDAREDLSRAEQHLDLNTDNECKLIIVKENQVATEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
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            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DAPPUDRAFT_63456"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="755"/>
            <end position="812"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX67983.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="945" mass="106534" checksum="9C4C0324B77C61FE" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKF0</accession>
    <name>E9HKF0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="6">
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            <taxon>Branchiopoda</taxon>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BicC family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_330715"/>
    </dbReference>
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9HKF0"/>
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    <dbReference type="OrthoDB" id="201055at2759"/>
    <dbReference type="PhylomeDB" id="E9HKF0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
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        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SAM"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="721"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="654"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX67775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="806" mass="89114" checksum="26BEB7EEDCB6C13A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLC8</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_261641</name>
    </gene>
    <organism evidence="2">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732678">
        <property type="protein sequence ID" value="EFX67452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67452">
        <property type="protein sequence ID" value="EFX67452"/>
        <property type="gene ID" value="DAPPUDRAFT_261641"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_261641"/>
    <dbReference type="HOGENOM" id="CLU_2851921_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="65" mass="7037" checksum="94C82E849F2C979E" modified="2011-04-05" version="1">MDSCSQYYFNTAVPCRLGEAARLDGTDQVGRCKTSVGAENKNSALWGSCCLQSWAGPLEQPATEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLH8</accession>
    <name>E9HLH8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAM_Exu domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_261701</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732679">
        <property type="protein sequence ID" value="EFX67412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67412"/>
    <dbReference type="EnsemblMetazoa" id="EFX67412">
        <property type="protein sequence ID" value="EFX67412"/>
        <property type="gene ID" value="DAPPUDRAFT_261701"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_261701"/>
    <dbReference type="eggNOG" id="ENOG502QVAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056447_0_0_1"/>
    <dbReference type="InParanoid" id="E9HLH8"/>
    <dbReference type="OMA" id="DEICHIA"/>
    <dbReference type="OrthoDB" id="744143at2759"/>
    <dbReference type="PhylomeDB" id="E9HLH8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045450">
        <property type="term" value="P:bicoid mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037998">
        <property type="entry name" value="Exu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040941">
        <property type="entry name" value="SAM_Exu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12384">
        <property type="entry name" value="PTHR12384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18609">
        <property type="entry name" value="SAM_Exu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM_Exu" evidence="2">
        <location>
            <begin position="313"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX67412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="449" mass="51431" checksum="D49BF8F465283218" modified="2011-04-05" version="1">MRLNKFVPSAMTRREDYTYKNKNTEMTNNSEEQQTSSSTEETIVEVVIQPPTPEAKVEFDASPAVITTQPAQPMPEHDDSIAVVMWEATVTGRRLIDEMINLGSFYVAQEEKAEGHDFNEYVMPYGKLPLNVIRNYNLRIVDTGRYRMLKEIRNNRMLKSKSEVAACNDFASWLIKLQKDNFPDKKIVLVFFEPRHSKILQLFQALERFRLLDDVNKILLGCVNGWDLLRQQVHDLKDEHRMVLKALADHHLGVDTPLESAVQRAQALHKILRKVHGGRINTGVLKENLISCDHLLEQVKKIKEELTKEAQWRPVFADMFRQGIKPRRRAGFLRHMLVESGITYVGLTETFKDKKDDGVVEVIKENIKGKNEADVEEVIKLLNQHLAQPDKPVRRGSGRRAPRTRSLCTATDLEKQQPASKIEPEENNNDPVKVIMDVIPSTPAVLSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9HM20</accession>
    <name>E9HM20_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_229224</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732684">
        <property type="protein sequence ID" value="EFX67156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67156">
        <property type="protein sequence ID" value="EFX67156"/>
        <property type="gene ID" value="DAPPUDRAFT_229224"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_229224"/>
    <dbReference type="HOGENOM" id="CLU_736223_0_0_1"/>
    <dbReference type="InParanoid" id="E9HM20"/>
    <dbReference type="OrthoDB" id="1276848at2759"/>
    <dbReference type="PhylomeDB" id="E9HM20"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030719">
        <property type="term" value="P:P granule organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="69"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="376" mass="42658" checksum="3AE2E779BB335ADE" modified="2011-04-05" version="1">MEFKNIKRKLAKAPKYSTLTGKEPAVCRPVRLQHTDEDVFGAYVLSIRTGNEVSFCRLTPNPVIDELWCETMDEMKNFYRENEAQLKPVETLEKDRLYAVKTNELWARALFSEFDETGDANFEMVDGGYFKTVSPSAVYPLECRFGIFPCQATRCVLYGLEYLTFVLNKVAIDTVLEHLVGKSLIASIVKRKPQLTVVFFEPPVINLNELILIQVAKSVRMIPLTDNEPNVPEDPLIEDPCIADRTKASVMDGLIFIAGLKCSQRPPASEVTVDGLYLGYNAKEGWSRMRLDSSIVRRRKVQVRMIDYENTVDTVWEKGLWDLNEISPELASIPVHQSVVLPLSCLCARVISLNKIDVQSTPATVQSFAHRHLYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9HM95</accession>
    <name>E9HM95_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminopeptidase</fullName>
            <ecNumber evidence="7">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_203795</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="7"/>
    <dbReference type="EMBL" id="GL732685">
        <property type="protein sequence ID" value="EFX67144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67144"/>
    <dbReference type="MEROPS" id="M01.018"/>
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        <property type="gene ID" value="DAPPUDRAFT_203795"/>
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        <property type="term" value="P:proteolysis"/>
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    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
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    </dbReference>
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        <property type="entry name" value="ERAP1-like_C_dom"/>
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        <property type="entry name" value="Peptidase_M1"/>
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    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
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        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
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        <property type="entry name" value="PTHR11533:SF246"/>
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    <dbReference type="Pfam" id="PF11838">
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    <dbReference type="Pfam" id="PF01433">
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    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
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    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
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    </dbReference>
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    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
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    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="18"/>
            <end position="210"/>
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        <location>
            <begin position="245"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF17900"/>
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        <source>
            <dbReference type="EMBL" id="EFX67144.1"/>
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    </evidence>
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        <source>
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    <sequence length="953" mass="107550" checksum="28D910CF41D7DCE2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9HN52</accession>
    <name>E9HN52_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_302417</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <reaction evidence="3">
            <text>(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH</text>
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            <dbReference type="Rhea" id="RHEA:31188"/>
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    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH</text>
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            <dbReference type="ChEBI" id="CHEBI:62613"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:31160"/>
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    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:31163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:62613"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:31165"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX66818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66818"/>
    <dbReference type="EnsemblMetazoa" id="EFX66818">
        <property type="protein sequence ID" value="EFX66818"/>
        <property type="gene ID" value="DAPPUDRAFT_302417"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302417"/>
    <dbReference type="eggNOG" id="KOG1683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_16_1_1"/>
    <dbReference type="InParanoid" id="E9HN52"/>
    <dbReference type="OMA" id="PFRYMDT"/>
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    <dbReference type="PhylomeDB" id="E9HN52"/>
    <dbReference type="UniPathway" id="UPA00659"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016507">
        <property type="term" value="C:mitochondrial fatty acid beta-oxidation multienzyme complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016509">
        <property type="term" value="F:long-chain-3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012803">
        <property type="entry name" value="Fa_ox_alpha_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="fa_ox_alpha_mit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="363"/>
            <end position="540"/>
        </location>
    </feature>
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        <location>
            <begin position="543"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00000469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001391"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX66818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="763" mass="82759" checksum="F3914C859E26649E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HN82</accession>
    <name>E9HN82_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_262570</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Laforsch C."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
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        <source>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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    <reference evidence="1 2" key="1">
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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                <person name="Detter J.C."/>
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    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="98" mass="10749" checksum="80B9C37894CFE4E5" modified="2011-04-05" version="1">MALWGVDSKTEYCPVYFTLLASKLHVLQQGTFHRTRELYINLGNWACAAALVRACRGKTKGDLSTCPAWLDLLDHQPVVAGIATFPYGFPTAVPRAPA</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Wang M."/>
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                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732747">
        <property type="protein sequence ID" value="EFX65372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX65372"/>
        <property type="gene ID" value="DAPPUDRAFT_117315"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG3510">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="E9HSA4"/>
    <dbReference type="OMA" id="ANKWYSN"/>
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    <dbReference type="PhylomeDB" id="E9HSA4"/>
    <dbReference type="Proteomes" id="UP000000305">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Manak J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
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    <accession>E9I1J5</accession>
    <name>E9I1J5_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Daphnia pulex</name>
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        </lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX62135.1"/>
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    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX62135">
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        <property type="gene ID" value="DAPPUDRAFT_120485"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S4C7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
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        <property type="entry name" value="PTHR30244"/>
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    </dbReference>
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        <property type="entry name" value="DegT_DnrJ_EryC1"/>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="210" mass="21458" checksum="51A8DA932D836130" modified="2011-04-05" version="1">MAALLFYLKPGEEVIMPSYTFVSTANAFVLRGAVPVFIDIRPDTLNMDETLIEEVSNTNTLGNIFTTGGNIGIETTAPTQALSVNGGAAPIKFLAQATKRMRITSSGNVGIGTTAPTYSLQILQDNTGAYPGDNTTGQLVISGIGTSSPCYTLDVSGAGRFTGGLTIATGGNVSIGTSSPCYTLDVSGAGRFTGGLTIATSTPGAWASNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
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    <name>E9I2F7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX61823"/>
        <property type="gene ID" value="DAPPUDRAFT_338022"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_338022"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="E9I2F7"/>
    <dbReference type="OrthoDB" id="1548094at2759"/>
    <dbReference type="PhylomeDB" id="E9I2F7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Collagen"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    </feature>
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            <begin position="103"/>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="296" mass="31972" checksum="4004E100AD9122AF" modified="2011-04-05" version="1" fragment="single">MTENRQPKVEVNIKPDSPSNQVVPKDSVETKPETELRRSQRSSQIAGRLQQLSTRSFELKHKVLKLKEKPKNDRREAKITKLEKEIAGIDKEFIDIYERNKTEIPAFDKSLSSTQEDYSSEQTDTEEEMPNTPTPSPGPPGQQGPPGQQGPPGQPGQDGQPGQDGQPGQQGAPGQVGQQGPPGNQGPPGNQGPPGPQGPPGPQGPIGQVGAGGIDPGDFRTFSAAMTTGMLNLAAVNYRKDIPEFSGDLDDNTTFESWLKKANRVGVEAGWTEDQKLKFFQSKLRRAAAAFNNSLG</sequence>
</entry>
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                <person name="Arnold G.J."/>
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                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="non-terminal residue" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="96" mass="10528" checksum="FCB42397600E5290" modified="2011-04-05" version="1" fragment="single">AFYCEKIRVFQAGFSPNTLAWNNGIGLRLTNAKAFAKDVFINQERKLGDQRRSDTVVVLTINYTDSGSAGIYVQSAPYEKSKSLGSGGSMVRKSET</sequence>
</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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        <source>
            <dbReference type="EMBL" id="EFX61720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="155" mass="17566" checksum="F85BA8C9F6B6BED6" modified="2011-04-05" version="1" fragment="single">MASKIGGKVKHEWGLTVTDEEKRPPKVDASAYAIDTTWMVPLEFQAPNKTNFLFKAGNKDYTLDGSSKNSSSSELSLKKKYARIYNLASHFFLMSIIDWSVSYRPETKTLFDIETALRFFHDGREATKLRIGNMARSLVEAWNKKYAGKSSIAND</sequence>
</entry>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        </location>
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            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX61464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="257" mass="26925" checksum="9C1D33D9B1F3C27B" modified="2011-04-05" version="1" fragment="single">MDLGSQMEASEQATQSELSRLQVHARALSSAAPASSVDQPGASSPKAQAPALQPEGWRSAAQLAAWLGHPWASELDRADATAHQRGISLTRFQVDLGAWGTRAGQPLAWRLQAAVPDDATALQWVQALGPQAELQRRDALPQPVPSERGTLSWRVDVSSVVDDVAIVTGRGGRSAPVGAAAPLVAPAGLAWPDRCLAAVGLRLVHAVGAAPSPRGPGPGRIRCAAAATRADRTGHTWQRDLDRGRSLERAFAGLDQP</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="1">Phospholip_A2_4 domain-containing protein</fullName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX61077"/>
        <property type="gene ID" value="DAPPUDRAFT_122566"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_122566"/>
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        <property type="project" value="InterPro"/>
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            <end position="203"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX61077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="349" mass="40671" checksum="C08CF1B4238CE589" modified="2011-04-05" version="1">MTRVVELTKLFFSQLFASLEIWGLPAYGQELPDLIPKNAPYFTYTEGKFKPSSIRLKEAMIAFFGQNTEFYLDWNKSNQAIYKTYDRPYYPSDVNWFWTFTKRKYGDALKTSPIGTDFSEWVKKLHEKQIRDRRAPIPERFKDPGYSLPGYNFCGPKNSMDYVPTTMLDAICQYHDLIYGYRPNSLERDDDKEFNIMLDNWSKANAGDGWSGPTFYEKQHVIPFIKGIFSAKDAVGSESPWTKEIIPSILKNYVTNFKKALTDPNGGSDFNQLARAKDSPLISIDNMYDHAFIETNDKRNPTRNRQYAALNDALDDLEDVKKWWNRQLLITRGSRSDPKSNQDYTRKEK</sequence>
</entry>
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    <name>E9I5M2_DAPPU</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="EMBL" id="GL735730">
        <property type="protein sequence ID" value="EFX60708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1708709_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="154" mass="16552" checksum="62046C13D3878E43" modified="2011-04-05" version="1" fragment="single">MVLPNVLKAADPPIPFRTITQAPENIVVVFPGAVYLVVDTGLICSEEAFFGMKDTRCDEFQFRYATMTKCRCNIRPTALCALYNMTENSFPNSLSLRSANLPRQLVAGKTARTVTAIADSTANLSGTSVPTRIVRFVPGDTRTTAGNAGAASSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRL4</accession>
    <name>E9FRL4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_189793</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX89867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89867"/>
    <dbReference type="EnsemblMetazoa" id="EFX89867">
        <property type="protein sequence ID" value="EFX89867"/>
        <property type="gene ID" value="DAPPUDRAFT_189793"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_189793"/>
    <dbReference type="eggNOG" id="KOG0755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_3_1"/>
    <dbReference type="InParanoid" id="E9FRL4"/>
    <dbReference type="OMA" id="VMSRMYN"/>
    <dbReference type="OrthoDB" id="1013743at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="Mitochondrial_sb/sol_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="Mt_carrier_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="SSF103506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="99"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="202"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX89867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="299" mass="32482" checksum="DA4B3D9B46D4A396" modified="2011-04-05" version="1">MEYAFGGLAACGACLFTNPLDVVKTRMQLQGELLSRGAYSVLYKNSLHAFYVVAKNDGIKGLQKGLVPALWYQMIMNGTRLGLYHFMENQGWTHSHGSVSSVFSIAAGAVSGASGAFSASPFYLIKTQLQSQSSQTIAVGCQHNHTGFLSAMQKLYYSGGITGLWRGVTASMMRTGVGSAAQLSTFTKSRETINNLNILPHNSWKSTLAAAMLSGVAVAVAMSPFDVISTRLYNQTLDRYGKGVYYSGPFECLIKVFKAEGFFGLYKGCLANYLRVGPHSVLTLTIWTFLRETKFEGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9FT81</accession>
    <name>E9FT81_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_233110</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89695">
        <property type="protein sequence ID" value="EFX89695"/>
        <property type="gene ID" value="DAPPUDRAFT_233110"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_233110"/>
    <dbReference type="HOGENOM" id="CLU_058897_0_0_1"/>
    <dbReference type="InParanoid" id="E9FT81"/>
    <dbReference type="OrthoDB" id="266752at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="343" mass="39180" checksum="7FD3725AA426D328" modified="2011-04-05" version="1">MSSLATCIGVYTVRYKLLVSTIAQKLILLNQQTREFIAPSRSCVVCVDRLHHARDNQDQQRLDQEEEKNGEAKNDDTHSNPQQRKPAEGKAHPSPATTTFKGKGTPIPRNFNLQKERAVRLSFTFEGHGDHYIKRVMQWCRATYATTSYCTEVFKYYTTKAPDLNSTTYAAPSHYTDGLKYYCAPSYYTTEATEDDYACCPILRGSYTQAPNCYTEVPADCCTEAAKYYSAPIYTTVTEAAKYCAVPAYCTEAALSYYVEQKYYADAPVHYTTTYATPQPPIYYTEAPKYYITKAPEFCTSMYATPAYYTEAPHYYNTEALKYYTTTCASPRYYTYVPKYYCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUY9</accession>
    <name>E9FUY9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_304801</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88804"/>
    <dbReference type="EnsemblMetazoa" id="EFX88804">
        <property type="protein sequence ID" value="EFX88804"/>
        <property type="gene ID" value="DAPPUDRAFT_304801"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304801"/>
    <dbReference type="eggNOG" id="KOG0467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_3_1_1"/>
    <dbReference type="InParanoid" id="E9FUY9"/>
    <dbReference type="OMA" id="MLGKMYA"/>
    <dbReference type="OrthoDB" id="140796at2759"/>
    <dbReference type="PhylomeDB" id="E9FUY9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="17"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX88804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1027" mass="114143" checksum="42BB4809A6A9C3C0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9FW11</accession>
    <name>E9FW11_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">P53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_304717</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the p53 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX89004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89004"/>
    <dbReference type="EnsemblMetazoa" id="EFX89004">
        <property type="protein sequence ID" value="EFX89004"/>
        <property type="gene ID" value="DAPPUDRAFT_304717"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304717"/>
    <dbReference type="eggNOG" id="ENOG502QQ48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_807152_0_0_1"/>
    <dbReference type="InParanoid" id="E9FW11"/>
    <dbReference type="OMA" id="VVSTRIC"/>
    <dbReference type="OrthoDB" id="257530at2759"/>
    <dbReference type="PhylomeDB" id="E9FW11"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08367">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011615">
        <property type="entry name" value="p53_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002117">
        <property type="entry name" value="p53_tumour_suppressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447">
        <property type="entry name" value="PTHR11447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00870">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00386">
        <property type="entry name" value="P53SUPPRESSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="SSF49417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="P53" evidence="9">
        <location>
            <begin position="48"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX89004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="344" mass="38894" checksum="CFEB7B26F2417ABB" modified="2011-04-05" version="1">MDGQPPGYYDFQQQQLMDTTTYPINNCPVVPINTSPTFDISNGVPAMELWPGHLKFTVEFSKAQDKTKATPWIYSTKLKKLFVSMDKACPISFRMDNLSQEFHRYCIRGQMVYSKADHFQDPVERCPAHKGTGPPLPYTPHVLRCEDNDSRYVDHSDMRHSVVVPLKPPAPGTQSVSLCYKFMCLSSCQGGLNRRPTKLIFTLESLTNGEVVGRYACDVRICSCPGRDIRAEEARFDKNHSHDPTATETDSSNLIPIELPSMAQLKGKIKKRKAIPPPQVAQTDSTEDDDGIYNLNVNIKGLKNYNFIKDIISRFQHDYDGFPPGNNDQANHTDTGKRFKKEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E9FW81</accession>
    <name>E9FW81_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_299507</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88680"/>
    <dbReference type="EnsemblMetazoa" id="EFX88680">
        <property type="protein sequence ID" value="EFX88680"/>
        <property type="gene ID" value="DAPPUDRAFT_299507"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299507"/>
    <dbReference type="eggNOG" id="KOG0794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034754_1_1_1"/>
    <dbReference type="InParanoid" id="E9FW81"/>
    <dbReference type="OMA" id="SHHQQWL"/>
    <dbReference type="OrthoDB" id="1079428at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-like_sf"/>
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    <dbReference type="Pfam" id="PF16899">
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="46"/>
            <end position="144"/>
        </location>
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    <feature type="domain" description="CYCLIN" evidence="6">
        <location>
            <begin position="157"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019492"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX88680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="265" mass="30796" checksum="88002F7795A4C056" modified="2011-04-05" version="1">MAGNFWQSSHCQQWLLDPSDLVRERQGDFAIVTEEDYQKLFIFFSNFIQVLGEHLKLKQQVIATATVYFKRFYARNSLKCIDPLLLAPTCILLASKVEEFGVISNNRLITTCQSVVKSKFNYAYPQEFPYRAQHILECEFYLLENMDCCLVVYQPYRPLVQFVQDIGQEDLLGLSWKIVNDSLRTDISLLYPPYQIALAAMQMACVVLQKDGKNWFAEIAVDTDKIQEITRQILALYDLYKTYDEKKEIQGLLAKMPKPKTQPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZ11</accession>
    <name>E9FZ11_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">DAPPUDRAFT_306448</name>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87677">
        <property type="protein sequence ID" value="EFX87677"/>
        <property type="gene ID" value="DAPPUDRAFT_306448"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306448"/>
    <dbReference type="HOGENOM" id="CLU_1476611_0_0_1"/>
    <dbReference type="OrthoDB" id="1780839at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240705" evidence="1">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX87677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="183" mass="20711" checksum="C32F0C78437AE12E" modified="2011-04-05" version="1">MESALLVWSILVILLATPRLGYAVQVDEFTNDEVETVAITYGIIPGLNEVKKLFNEARREKREVAPEQDLSRFQTTNLNCKNSVEQLTTKFRQKIANVPKPVGSNDQATLATLANIERAIRNASQELEEECAWKDSINKPVEATRTQFLTTEVNDMGSEGIVIYQIGIQKLEFEDPYNRPNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZ83</accession>
    <name>E9FZ83_DAPPU</name>
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        <recommendedName>
            <fullName evidence="3">TIMELESS domain-containing protein</fullName>
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    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_312499</name>
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    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87310">
        <property type="protein sequence ID" value="EFX87310"/>
        <property type="gene ID" value="DAPPUDRAFT_312499"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312499"/>
    <dbReference type="HOGENOM" id="CLU_2335751_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:DNA replication checkpoint signaling"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009649">
        <property type="term" value="P:entrainment of circadian clock"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Timeless"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX87310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="98" mass="11029" checksum="894F4CE853E540D9" modified="2011-04-05" version="1">MDHWIKLSGEVPCLSLIPLGSFPNKYCMDPECLNNLKEINAKLSCEEPNTRPLIAYAIGFFNVLNEDLIHILHSSKDQPTICPSIFPTTITYSNVYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZM8</accession>
    <name>E9FZM8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein DpuGr44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DpuGr44</name>
        <name evidence="6" type="ORF">DAPPUDRAFT_312608</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87084">
        <property type="protein sequence ID" value="EFX87084"/>
        <property type="gene ID" value="DAPPUDRAFT_312608"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312608"/>
    <dbReference type="HOGENOM" id="CLU_654286_0_0_1"/>
    <dbReference type="InParanoid" id="E9FZM8"/>
    <dbReference type="PhylomeDB" id="E9FZM8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033041">
        <property type="term" value="F:sweet taste receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009318">
        <property type="entry name" value="Gustatory_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421">
        <property type="entry name" value="PTHR21421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX87084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="352" mass="40511" checksum="C43257CDF7A53C32" modified="2011-04-05" version="1">MIFQLSRTVVAVQSMTTVHSVIPFLLWLSAIPLAVVTQIWYIARRRDLLAFFKDWDLFEKYLDVRYSHQELVYPMVRKPRILVYTSKLVTLLVLVVGLSMIIFNFPDAPYLLTNFQALRDVIPIPILGFIHLVNVILVLGLTTLCETVPALVFFHFQCQVHVLQREFDNVFKLFNSQCNYHKLSGRLDFDPGLFFAAQLRQLFEFYETVRLFVGRANSLFGVLLFLNHGMRLIVICVMLYSVLYLLQSTPVTAGIYLINFCIHLCELVTSTLLTAQLYRASDRLRTHLAVLLTRYWDSIPNEERKLLVHFNGRIQTDPLAATPLGLYNVTPSFLLTVASLAVTYVIILLQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9G164</accession>
    <name>E9G164_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_97747</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86616">
        <property type="protein sequence ID" value="EFX86616"/>
        <property type="gene ID" value="DAPPUDRAFT_97747"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_97747"/>
    <dbReference type="HOGENOM" id="CLU_1416479_0_0_1"/>
    <dbReference type="OMA" id="YIADEGG"/>
    <dbReference type="OrthoDB" id="1591828at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX86616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="192" mass="18951" checksum="DBF46342A9DFEC12" modified="2011-04-05" version="1">MEKNDQKDIKGGRCFLAVGFAAVVQAGLPEAGGFRYAVNDFNGNEQSHQQNRGPGNAVNGQYKVLLPDGRLQTVTYIADEGGYRAKVDYTPAAPGEATTAGKGLPLPATSRFSSVIGNGYGGGGVAGGFGASAFGAAPYGAGAIAAGALGAAGSYGSGFGFGDAIWLRNTGSYGGGFGGGNNYGVGVSGGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1C9</accession>
    <name>E9G1C9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DAPPUDRAFT_222043</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.2" evidence="3"/>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86656"/>
    <dbReference type="EnsemblMetazoa" id="EFX86656">
        <property type="protein sequence ID" value="EFX86656"/>
        <property type="gene ID" value="DAPPUDRAFT_222043"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_222043"/>
    <dbReference type="eggNOG" id="KOG0368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_5_2_1"/>
    <dbReference type="InParanoid" id="E9G1C9"/>
    <dbReference type="OMA" id="LIQCAMP"/>
    <dbReference type="OrthoDB" id="156081at2759"/>
    <dbReference type="PhylomeDB" id="E9G1C9"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX84449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84449"/>
    <dbReference type="EnsemblMetazoa" id="EFX84449">
        <property type="protein sequence ID" value="EFX84449"/>
        <property type="gene ID" value="DAPPUDRAFT_46900"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_46900"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_002678_2_1_1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240083" evidence="2">
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            <begin position="26"/>
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        </location>
    </feature>
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            <begin position="203"/>
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        </location>
    </feature>
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            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
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    </feature>
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            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX84449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="337" mass="37872" checksum="DD8783732DA56D5A" modified="2011-04-05" version="1" fragment="single">MWIYLFIQRLTFFYVVYLVPPPVESLPALTPLGPPPPLPSPISPSKSYGTRASSIRSVQSTYGPDACGICGARGLSDGLSRYLHAHLHHQRHACLVCGSMHAKVAALVKHLQAFCVEPLDKTYSCDLCNVNELSVKEMVQHLRGAHGFRMYPCLECGQQFKTYGYFISHLVSTGKESIYGCRLCGIVGMVSLYMLQSHLRTHSLCDICHTCFESQTALRKHMFNHQQDSPYACTVCQVSYKNYESLEMHLLWKHGTESKPCPTCQEKTWLCTYHFCPGAPASLAEVVDNPCVCTVCRLEFSKASMLKVHTRLHTGERPHKCHSCKKSFISKKLLAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7D7</accession>
    <name>E9G7D7_DAPPU</name>
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        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_314766</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="71"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="152"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="384"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX84450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="693" mass="78848" checksum="FEF8B83E62ACCAA4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7Q6</accession>
    <name>E9G7Q6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_238896</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84521">
        <property type="protein sequence ID" value="EFX84521"/>
        <property type="gene ID" value="DAPPUDRAFT_238896"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238896"/>
    <dbReference type="HOGENOM" id="CLU_2443050_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX84521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="90" mass="9936" checksum="58FBBBCE469B0E6B" modified="2011-04-05" version="1">MLKKDNIFAITLRFFIPRFSPVIWNDALTFACFHTATIVDEKNGGVNPYNETEAYARAGHYGATVVSPGFNSSYVRQATSCTSEPPETAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9G887</accession>
    <name>E9G887_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_194533</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84316"/>
    <dbReference type="EnsemblMetazoa" id="EFX84316">
        <property type="protein sequence ID" value="EFX84316"/>
        <property type="gene ID" value="DAPPUDRAFT_194533"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_194533"/>
    <dbReference type="eggNOG" id="KOG0522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026137_2_0_1"/>
    <dbReference type="InParanoid" id="E9G887"/>
    <dbReference type="OMA" id="IDEYECK"/>
    <dbReference type="OrthoDB" id="425969at2759"/>
    <dbReference type="PhylomeDB" id="E9G887"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="PTHR12447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="GPCR_chapero_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX84316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="457" mass="51101" checksum="CC6FEADC1754D3E4" modified="2011-04-05" version="1">MLAVTLENLDCAILLLENGANVNVENKEGWTVVQEAVSTGNHQIISAVLQKRDLQRHTTRMLGVPALLQKLKEAPDFYMEMKWEFTSWVPLVSRMCPSDTYKVYKQGSNVRIDTTLLGFDQSSWQRGSKSYLFKSEGVDKAVLLEMDHEAKEVFVEELRTLQEDTVTRHLMTPSNAAVMARVTSPIVHTYVDTEKISFERNKSGLWGWRSDKTEVVNGRDCKVFSASNVELVTKTRTEHLSPEDKSKVAGSGFLLNSLLAVGQHLEESTSLPDGTNPDKVTMEEYFDSSVDLGKRDIGRPKEMTTKVQKFKATLWLAEEFPLSLVDQIMPIVDLMAISSTHFAKLRDFIQMQLPAGFPTKIEIPLFHVMNACITFGNTFGLDEAINGVSIIQEADRLSCVVDDSCFVTPGDYTLYGVGGASVNSPSRRQFSMDEEDELLQYAIQQSLLDVGSEGDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8M9</accession>
    <name>E9G8M9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_315078</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX83997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83997">
        <property type="protein sequence ID" value="EFX83997"/>
        <property type="gene ID" value="DAPPUDRAFT_315078"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315078"/>
    <dbReference type="HOGENOM" id="CLU_875111_0_0_1"/>
    <dbReference type="InParanoid" id="E9G8M9"/>
    <dbReference type="OrthoDB" id="1194521at2759"/>
    <dbReference type="PhylomeDB" id="E9G8M9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237251" evidence="4">
        <location>
            <begin position="21"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX83997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="318" mass="36296" checksum="4AFED4E408D249F0" modified="2011-04-05" version="1">MKVFVLLALAFTGLADSAAANQVWYDKDRFTDPYHNAPGYKKPENEYQGGQHHSEPYDEHGTYNYNYNVKDAHSSIDYGKQETSNGKGAVSGSYHVMLPDGRKQKVTYHADENGYVADIQYEGEAKNDETPYSAGSYPTIYAKKDGKNDETPQHNYPVNHYPSTTTEKYHDTYSTTPTKDHQMYHHQTHYVKPNIPHVKYPDIYSTPYNTGHETHHTPYAKDNTHSATPYNKGQYHHQVPYVKEHDASSIKYNPNPHSKSPHHYSTSYPKASENYQTSYVKSHSNHPVPYSKGSYNHGTVKTAKYPDTHPTTYSNGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAF2</accession>
    <name>E9GAF2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">5'-nucleotidase</fullName>
            <ecNumber evidence="3 7">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_194977</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the pyrimidine 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3 7"/>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83230"/>
    <dbReference type="EnsemblMetazoa" id="EFX83230">
        <property type="protein sequence ID" value="EFX83230"/>
        <property type="gene ID" value="DAPPUDRAFT_194977"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_194977"/>
    <dbReference type="eggNOG" id="KOG3128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048584_0_2_1"/>
    <dbReference type="InParanoid" id="E9GAF2"/>
    <dbReference type="OMA" id="DNADIMM"/>
    <dbReference type="OrthoDB" id="1171042at2759"/>
    <dbReference type="PhylomeDB" id="E9GAF2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006434">
        <property type="entry name" value="Pyrimidine_nucleotidase_eu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05822">
        <property type="entry name" value="UMPH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01128">
        <property type="entry name" value="C1.4:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01544">
        <property type="entry name" value="HAD-SF-IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX83230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="297" mass="33859" checksum="CFA29DCC859C91A2" modified="2011-04-05" version="1">MDNLISLIPNLKLSHVHVKDWQNVGDKINKLIAGTHDKLQVIADFDFTLTKFHVDGVRKLSCHGVVENYSKLPDHYKLKSKEMFNKYYPIEIDQHLSVEEKIPLMIEWYDGAHELLEHSNLYKHDFALMVKENPIEFRDGTLQFMKDLNAANIPILVFSAGVGDVIDEALLANNLTQDNVKVISNYMTYNTEGKLVAFTDKLIHMYNKNETSIPHSSTYFQDLSHRHNVILLGDSLGDLQMSKGVEPPSTVLTIGFLNDKIEERLEKYKGEFDIVLVDDQSMDIPDAILKSVLANES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAH6</accession>
    <name>E9GAH6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_100474</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83525"/>
    <dbReference type="EnsemblMetazoa" id="EFX83525">
        <property type="protein sequence ID" value="EFX83525"/>
        <property type="gene ID" value="DAPPUDRAFT_100474"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_100474"/>
    <dbReference type="eggNOG" id="KOG1052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402949_0_0_1"/>
    <dbReference type="InParanoid" id="E9GAH6"/>
    <dbReference type="OrthoDB" id="188544at2759"/>
    <dbReference type="PhylomeDB" id="E9GAH6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004970">
        <property type="term" value="F:ionotropic glutamate receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Lig_chan-Glu_bd" evidence="5">
        <location>
            <begin position="51"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Lig_chan-Glu_bd" evidence="5">
        <location>
            <begin position="342"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX83525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="683" mass="77260" checksum="A230CDC5D78FAA0E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAM1</accession>
    <name>E9GAM1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_315729</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="411" mass="44859" checksum="84E6B723B04B33BF" modified="2011-04-05" version="1">MDFRSSQLSRGHLNQQLHNRSFDTGQHHQNKRAAAYAYSSSEESLNLSFAQQPPDHQQQQDEETVETLCEIPLIHHSTSTPSLVAHPSFGQMVANNHWLNIGSSSSTPRPVTSGKRRSVQPYSCTSTDDPPGLPHQYQLLLQQTAAIKTTLSGLEADFGASRRDMGWLQENLTTVQSATGSVSDKVVKMQSQVANMERQINGAVKEAQQLQQRANDALKSASDAERDFRRLENDCQSLLNQLLRQQQSSNSLADPLCLSPMTPHPPGLMMMSFQQQQQHGADTSGHHFSSQRSSSQLPPLAPVPQLNIPPTFDFAALLTKSMPIGSSAVAAAEPRMKSSFRSEGVNKNGTKSISFGPITTYATSPTTDPDDVIPAATSTLLRKTISHSSGPSFVLPVSDFNQNSPHSMMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9GGM4</accession>
    <name>E9GGM4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable RNA-binding protein 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">RNA-binding motif protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_224305</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732543">
        <property type="protein sequence ID" value="EFX81417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81417">
        <property type="protein sequence ID" value="EFX81417"/>
        <property type="gene ID" value="DAPPUDRAFT_224305"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_224305"/>
    <dbReference type="eggNOG" id="ENOG502S20K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066926_3_1_1"/>
    <dbReference type="InParanoid" id="E9GGM4"/>
    <dbReference type="OMA" id="YTHPNND"/>
    <dbReference type="OrthoDB" id="1566886at2759"/>
    <dbReference type="PhylomeDB" id="E9GGM4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12355">
        <property type="entry name" value="RRM_RBM18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039157">
        <property type="entry name" value="RBM18_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX81417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="203" mass="22819" checksum="B33D97D5869CADA8" modified="2011-04-05" version="1">MNSTAEMDKDDPMLDLYTHPNNDSRIWVGNLDSRVTEFELVKLFQNAGTIDKLEYLFHKIGPQAGQPRGYAFLTFSKREEAIRARKEFDGKSLLGRTLLVKPARSVQKDDLTGPKTTQFSIPALSGAKDNKNKLNLEQQIKAIESKLKTMENSSATLPDLPPNFVSPLSRIAARPAAQPYPSRSNRSRGSRGRGRGGYRDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9GI29</accession>
    <name>E9GI29_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_243106</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="GL732545">
        <property type="protein sequence ID" value="EFX80940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80940"/>
    <dbReference type="EnsemblMetazoa" id="EFX80940">
        <property type="protein sequence ID" value="EFX80940"/>
        <property type="gene ID" value="DAPPUDRAFT_243106"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_243106"/>
    <dbReference type="eggNOG" id="KOG1849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_970640_0_0_1"/>
    <dbReference type="InParanoid" id="E9GI29"/>
    <dbReference type="OrthoDB" id="1212152at2759"/>
    <dbReference type="PhylomeDB" id="E9GI29"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000280">
        <property type="term" value="P:nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="PTHR12792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="5">
        <location>
            <begin position="90"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX80940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="287" mass="31979" checksum="2D1455D77DCD482B" modified="2011-04-05" version="1">MQEVLSLFKTVQPDLEKFKTAKRNPVILVLDKVIQKLPWESMAMLSTTPVSRIPSLHFLNSLTWKHSFDRPNPSPTTELKLRSNGIEVNPKLAYYIINPGQDLPGVQLRLQPILEKIWGKQCGLSGAVPVEQEIKQSLMERDIFLYCGHGSGSKYFPMDNLVKMDCRAAPILMGCSSGQLTVSGRIADPTGAPIYYLLAGSPGMVGMLWEVTDVDCDRFTIRLLDLLLGARKRKVLEKLNHTPPNERSVKTDLPSPPEQLEPEMLRAVAQSRPVTKNFLTGAAAVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIG2</accession>
    <name>E9GIG2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_303924</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_303924"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EGF-like_dom"/>
    </dbReference>
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        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
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    </dbReference>
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        <property type="entry name" value="EGF_1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LDLRB"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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    <feature type="chain" id="PRO_5003241244" description="EGF-like domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="2">
        <location>
            <begin position="166"/>
            <end position="210"/>
        </location>
    </feature>
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            <begin position="336"/>
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        </location>
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            <begin position="340"/>
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        </location>
    </feature>
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            <begin position="362"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX80773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="495" mass="56317" checksum="671DDE4CD124C774" modified="2011-04-05" version="1">MKFGGLFIFVALKLAAVVSVKQDDLIIAVGNKLEFLKDGSTYQTLALDSYNASKFSALAYDATTQKLFFSDIRHRHGHIFSVSLDSESRRNVEDIVEKKSNETVESLTYDPVDNVLLWTDGLNKSIRRIQIDHDRVHSEEKAGVEVVHFLEYDAKPRGLVSDPCTRMLYWTNIHNSRPTIERSFLNGSRREIVVETDLLLPNSLDLDVVEQRLYWAESLPNGYFHIERSFVNGTGRQEIYRGTGQFVVNLAVGVDYVYWSDYDHKKLWFLRKDGSSKRPLSLGTFRDPVMSVVLFRRQSIDCCLVSSSETCQPTKEVLVKSQPEVILESTSSKHDDVDICTGFCYHNGDCTILLNSVLRCSCPVGFSGDRCELLDGQSDAWSYDNPEVEEMDRENETMTLDQMSSSFETIAKTCIPITCFVLIAIFAIVKLRLFTTIFESLRRDKDDNAAVVQNLENCYKMCERPFPQLQAVNAPVPDNSWKQSGDRATLIENEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJS1</accession>
    <name>E9GJS1_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_243900</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732548">
        <property type="protein sequence ID" value="EFX80159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80159">
        <property type="protein sequence ID" value="EFX80159"/>
        <property type="gene ID" value="DAPPUDRAFT_243900"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_243900"/>
    <dbReference type="HOGENOM" id="CLU_2981167_0_0_1"/>
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    <dbReference type="PhylomeDB" id="E9GJS1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="58" mass="5969" checksum="EBFA15BDEEB3DB33" modified="2011-04-05" version="1">MANVSPGPGVNCRNNRMETPLIVAAQNSAIRAITSLTALGADVDAQDANGNTAMHYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJU1</accession>
    <name>E9GJU1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_318843</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732548">
        <property type="protein sequence ID" value="EFX80172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80172">
        <property type="protein sequence ID" value="EFX80172"/>
        <property type="gene ID" value="DAPPUDRAFT_318843"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_318843"/>
    <dbReference type="HOGENOM" id="CLU_1919159_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX80172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="132" mass="15198" checksum="D239FBC802A8C54F" modified="2011-04-05" version="1">MRICNLHFEENCFTKETNKLLKDAVPTIFKFTAKPKDVPRHSQEYLHRIGILADVEIIGFNNNVWITIVIFAWSNSSLKQVSAEYLPYFLEPVSGTLEMLEQLLERVCFHLDPLSDWPLSQDVECIAVASLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GK94</accession>
    <name>E9GK94_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_244124</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732549">
        <property type="protein sequence ID" value="EFX80098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80098">
        <property type="protein sequence ID" value="EFX80098"/>
        <property type="gene ID" value="DAPPUDRAFT_244124"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_244124"/>
    <dbReference type="HOGENOM" id="CLU_2963110_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX80098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="59" mass="6708" checksum="F2FFB128893F938C" modified="2011-04-05" version="1">MSGSHRRSRIGFRRGGVAKVGPYWRMTYNYFVVACWHASKRHLTLRAGAPAETSIKRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9GLC9</accession>
    <name>E9GLC9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein-lysine N-methyltransferase DAPPUDRAFT_52203</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_52203</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="GL732551">
        <property type="protein sequence ID" value="EFX79490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79490"/>
    <dbReference type="EnsemblMetazoa" id="EFX79490">
        <property type="protein sequence ID" value="EFX79490"/>
        <property type="gene ID" value="DAPPUDRAFT_52203"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_52203"/>
    <dbReference type="eggNOG" id="KOG3350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074410_2_1_1"/>
    <dbReference type="InParanoid" id="E9GLC9"/>
    <dbReference type="OMA" id="HKCNFRP"/>
    <dbReference type="OrthoDB" id="1272987at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018022">
        <property type="term" value="P:peptidyl-lysine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="PTHR13200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX79490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="230" mass="26670" checksum="C064394E3328C45E" modified="2011-04-05" version="1">MIFNEEKDDDDEDEPELSLSTLAALNEFLSEKKEREERLRSIAESAEKDNKILDEVVLEEDWQLSQFWYDDHTSAVLAREALRLAGSEGRIACISCPTLYKELRKWKPESVKAHLFEYDTRFSVYGDDFTFYDYHSPLEVPRELSSSFEVVVADPPFLSEECLTKTALTMRYLSKGPLILCTGSIMEDLAGRLLQLKMCAFQPKHRNNLANYFRCYANYDFDSTLITHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTT8</accession>
    <name>E9GTT8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_305928</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732564">
        <property type="protein sequence ID" value="EFX77131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77131"/>
    <dbReference type="MEROPS" id="S01.413"/>
    <dbReference type="EnsemblMetazoa" id="EFX77131">
        <property type="protein sequence ID" value="EFX77131"/>
        <property type="gene ID" value="DAPPUDRAFT_305928"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305928"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_0_3_1"/>
    <dbReference type="InParanoid" id="E9GTT8"/>
    <dbReference type="OMA" id="SNILMEV"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="PhylomeDB" id="E9GTT8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="108"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX77131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="340" mass="37578" checksum="A154A93465814180" modified="2011-04-05" version="1">MIIILHSSPIIVIHIQPDFAYETCSTPLSQSGRCRFVQHCARQEIIATLNAFVSYACPIGSDYMGVCCPDNTQPTVDIVLHLKVSQIDFMDLIDTLGCGELMKQTTRIVGGVPADKGEWPWMAALLRDKTDQYCGGVLITDQHILTASHCVDNFKPEELTVRLGEYDFSQVSEARRDFGAEAIYMHESYDRRTYKNDIALIKLKTKATFNSDIWPICLPPSNVVLEGQSAFVTGWGTTSYSGQASDVLLEVILPIWALADCQKAYTQPISEQQLCAGYKAGGKDSCQGDSGGPLMYQMSTGRWAVVGVVSWGIRCAEKDKPGVYTRVTSYSDWIKAKVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9GVN7</accession>
    <name>E9GVN7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_322353</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX76445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76445">
        <property type="protein sequence ID" value="EFX76445"/>
        <property type="gene ID" value="DAPPUDRAFT_322353"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_322353"/>
    <dbReference type="HOGENOM" id="CLU_049894_14_0_1"/>
    <dbReference type="InParanoid" id="E9GVN7"/>
    <dbReference type="OrthoDB" id="1509611at2759"/>
    <dbReference type="PhylomeDB" id="E9GVN7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237491" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="67"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX76445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="192" mass="21415" checksum="3BE348BCA15E166E" modified="2011-04-05" version="1">MQAFSFPGIFVCIVGVLLFKGQVSEQLAVIQQESGSDMIPADQTTLIEDKTEVACQGSIGTNKCIKTNGVCYCFVPQQLPWLKAYEFCNSYRKNLISIQSSTDQQVVTQFLMPLILNDPVAKNIGVWTSGASVPGLKTYFWVSKLSLFFYSNWFYGEPRPTSLSECVRIAPVPEGPWASTPCEQWLPFVCQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9GVV9</accession>
    <name>E9GVV9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_226067</name>
        <name evidence="5" type="ORF">DAPPUDRAFT_337234</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733739">
        <property type="protein sequence ID" value="EFX62227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732569">
        <property type="protein sequence ID" value="EFX76248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX62227"/>
    <dbReference type="EnsemblMetazoa" id="EFX62227">
        <property type="protein sequence ID" value="EFX62227"/>
        <property type="gene ID" value="DAPPUDRAFT_337234"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76248">
        <property type="protein sequence ID" value="EFX76248"/>
        <property type="gene ID" value="DAPPUDRAFT_226067"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_226067"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_337234"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_7_0_1"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010831021" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="50"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX62227.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="301" mass="32676" checksum="28B043F36F254B6B" modified="2011-04-05" version="1">MFGSCWIYTAVFVYALLAVLKTGAVTKDVTIFGDDSISRNQTTKVNFTRIVGGAWAKRGAYPYQVAIYVKKEFTCGGTLLEGGLHVLTAAHCINPLGREAGLITLYFRTTVLNPLDAIHIERKAAKFVTHPSYNSTSFENDLGVITLSKPVFEIRPVKLERVDPFNQTHIGKEATVIGWGRTRQVLHPAMSSGAASNHLRHVNVTILDTKDCSVLYYHDYELSDGKRLCASTLFGKSICQGDSGGPLLINGLQVGINSAAAGCADPRFPALFIRVSAYVDWIKTVVGKSVPVLPVTLITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E9GVY3</accession>
    <name>E9GVY3_DAPPU</name>
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        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DAPPUDRAFT_55220</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX76255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76255"/>
    <dbReference type="EnsemblMetazoa" id="EFX76255">
        <property type="protein sequence ID" value="EFX76255"/>
        <property type="gene ID" value="DAPPUDRAFT_55220"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_55220"/>
    <dbReference type="eggNOG" id="KOG1052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007257_1_1_1"/>
    <dbReference type="InParanoid" id="E9GVY3"/>
    <dbReference type="OMA" id="IMVAIFE"/>
    <dbReference type="OrthoDB" id="188544at2759"/>
    <dbReference type="PhylomeDB" id="E9GVY3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004970">
        <property type="term" value="F:ionotropic glutamate receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="805"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="18">
        <location>
            <begin position="414"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Lig_chan-Glu_bd" evidence="19">
        <location>
            <begin position="424"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFX76255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="912" mass="104392" checksum="3635CEDF791FF8C7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYQ3</accession>
    <name>E9GYQ3_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_107964</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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            <begin position="1"/>
            <end position="47"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="116" mass="12927" checksum="A28B3D56C12BD0E8" modified="2011-04-05" version="1">MSFRRQHRQAGTAGETSSRWAWPPMGGEGGTVGAAKGPRGGSLSALDLLDRSADEPDVGWPQTEAELATFYQSSIMDQQQRHLEPLREDLADWLNKILDTRRRDLKVLEGSRSLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYT9</accession>
    <name>E9GYT9_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3">
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        <name type="common">Water flea</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732576">
        <property type="protein sequence ID" value="EFX75353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="105" mass="12255" checksum="A162BEF208DEAD90" modified="2011-04-05" version="1">MLESARIQRPASSKKTAIKTHNHLPELDQQRHVALVNNCAVEACISRDPPREIFDRIRRGYPGLLVTYNDATQRRIQRAKRSMETRIPKTIDEAYELLMQHPEYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZK3</accession>
    <name>E9GZK3_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_306911</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732593">
        <property type="protein sequence ID" value="EFX73127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73127">
        <property type="protein sequence ID" value="EFX73127"/>
        <property type="gene ID" value="DAPPUDRAFT_325589"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_325589"/>
    <dbReference type="eggNOG" id="KOG1362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1422834_0_0_1"/>
    <dbReference type="InParanoid" id="E9H573"/>
    <dbReference type="OrthoDB" id="329225at2759"/>
    <dbReference type="PhylomeDB" id="E9H573"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="PTHR12385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX73127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="191" mass="21514" checksum="6C0F3E0C66126E94" modified="2011-04-05" version="1">MGWVRNAGASRTRPQTRSPPILNRCLAIHASSTEATNWFLTSTGLAKFLNQFAIDFQLCWKEVDYLCLIALGLSLVLTVLFRFLAGAMIWLLLVALVLGSFGGTGYLWWAWYGMRGTSGETSMLAYAITLSIISVLILLIVVAMRKRVELVAALFREATTPLFLSIIIEFISNHFGSKPHKFRYVIDYLQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6L9</accession>
    <name>E9H6L9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_326063</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732598">
        <property type="protein sequence ID" value="EFX72611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72611"/>
    <dbReference type="EnsemblMetazoa" id="EFX72611">
        <property type="protein sequence ID" value="EFX72611"/>
        <property type="gene ID" value="DAPPUDRAFT_326063"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326063"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="InParanoid" id="E9H6L9"/>
    <dbReference type="OMA" id="WQGITWV"/>
    <dbReference type="OrthoDB" id="430696at2759"/>
    <dbReference type="PhylomeDB" id="E9H6L9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="10">
        <location>
            <begin position="23"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX72611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="478" mass="52063" checksum="37099C29E2D46624" modified="2011-04-05" version="1">MESAITDNEIDFSKANKRPQILAALAAAFSAFVMGTTFGWSSPVQPQLQQNSTLNTVVDQNSTWYIDLDDDQMSWVGSLINIGASVGAICGGYLMDRFGRVFVLMAVSIPFFTGWLFIVLAVDPLMLYVGRLLGGLAAGICCAVAPCYIGEISIPDIRGTVGYFFSTNIGLGILFTQILGLGLDWRFISGVCAITPLVLFALLYFVPESPYFLVKNNKMDKAAKSLQWLRGNLFNVEAELAQIKSRVIEDKTQQLNLRDFLRPWAYKPILIGIAVMVFQQFSGLNAALFYSVEILQVAGSNLDALVSAVVVIITLLIGNFLGAVVVGRLGRRPLFMISEAIACLSMCVLGSYFYILTNDPEAAKPLAWLPLTSLIVFISGIGMGLGPLPWIISSEVLPAKIRGQGSSIAALANFGLSFIVTKTFIDIQRAVTPAGAFWFYGGFCLLGILFALFLLPETKDKTSEQIEAFFVTPNHNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6Q7</accession>
    <name>E9H6Q7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_227431</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">Protein modification; protein glycosylation.</text>
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        <subcellularLocation>
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    </dbReference>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EFX71752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="103" mass="11883" checksum="0BFEAFF6C68799BF" modified="2011-04-05" version="1">MSCHLCISVTAFSKEHTEIYIDSINKMILQPKTTSTHRCLYTAFEIFRGAPSITIDKIIKLGEGSLGTVYRRKRKGIPVAVKEIKLQNMDTKFFQREEKENMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9C0</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
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                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732608">
        <property type="protein sequence ID" value="EFX71682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71682">
        <property type="protein sequence ID" value="EFX71682"/>
        <property type="gene ID" value="DAPPUDRAFT_111484"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_111484"/>
    <dbReference type="HOGENOM" id="CLU_1620717_0_0_1"/>
    <dbReference type="OrthoDB" id="1904979at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="164" mass="17309" checksum="17AECA5C74D44D95" modified="2011-04-05" version="1">MTTSLCNKPPVPRPRQCWQQQQPKTTSTPSPSGNSKSGIQLSDDDVYRFLGKQFCLPRSPASAPASSRTEANKPAINHPVSNVTAAATAAAAAKAPPKPPRSINVMSASSAASYSKAPKPLPRTMFLAVKTPPIRPSRPPVSYGSLRNQTSPAESNGIKSFGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9H0</accession>
    <name>E9H9H0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_18317</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732608">
        <property type="protein sequence ID" value="EFX71653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71653">
        <property type="protein sequence ID" value="EFX71653"/>
        <property type="gene ID" value="DAPPUDRAFT_18317"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_18317"/>
    <dbReference type="HOGENOM" id="CLU_075165_6_1_1"/>
    <dbReference type="InParanoid" id="E9H9H0"/>
    <dbReference type="PhylomeDB" id="E9H9H0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="68" mass="7829" checksum="E93511538FFED904" modified="2011-04-05" version="1" fragment="single">MPYSFAWAVKDDYTYNDYAHQETADDKGYVSGSYRTLLPDGRTQTVTYKVDDYSGYVADVKYDGEAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9HB51</accession>
    <name>E9HB51_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_112181</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732614">
        <property type="protein sequence ID" value="EFX71023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71023"/>
    <dbReference type="EnsemblMetazoa" id="EFX71023">
        <property type="protein sequence ID" value="EFX71023"/>
        <property type="gene ID" value="DAPPUDRAFT_112181"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_112181"/>
    <dbReference type="eggNOG" id="KOG0019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_722126_0_0_1"/>
    <dbReference type="InParanoid" id="E9HB51"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241009" evidence="4">
        <location>
            <begin position="31"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX71023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="383" mass="43607" checksum="A1B49EC84C08297B" modified="2011-04-05" version="1">MGTNTLTHNLWVALILKWLIILLAPDGVRLQHLQLLRSDASLHDDGAEKEEKKDENEEKPKVEDVDEEADKEAGKKKKKTIKEKYSADEELNKTKPVWTRNPDDVSQKEYGEFYKSLANDWEDHLAVKHSLMKASSSSVLSSSSHAVLLSICLRTANRRTTSSSKQDLEGNFISLYYHNIFFFVSDLLASSIFIDPENDTASLLAQYNTDVRAVLDKHAPLITKRLTIRTCRRSLRRWERKYRARGLTIDRECLTNAREALKKLIFEKKSSFITQKITESAGKRSLFKLVDSFLLKKPALRLPDHDSLPSLVERFSVYFDTKISTIRSVLDSTDSFPSHDESVNLKCDFSLFRPITISETVALIMSCPAKSSPLDPLPTSLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HB98</accession>
    <name>E9HB98_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_327625</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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    </evidence>
    <sequence length="73" mass="8308" checksum="D779848613C31248" modified="2011-04-05" version="1">MNISVCFLEKRARSFFMESCGPGTEILVPMLTFVHDGRGTSINVLLHPYLRDARSSSFTASKHNWFYFALASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDP8</accession>
    <name>E9HDP8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_257503</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732625">
        <property type="protein sequence ID" value="EFX70064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70064">
        <property type="protein sequence ID" value="EFX70064"/>
        <property type="gene ID" value="DAPPUDRAFT_257503"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_257503"/>
    <dbReference type="HOGENOM" id="CLU_041599_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10523">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEN" evidence="3">
        <location>
            <begin position="391"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="298"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX70064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="506" mass="57593" checksum="FD8E05CB878A0F95" modified="2011-04-05" version="1">MAPEAPTSHHNQQQDRQQPHFKNPSSGGERRMKFGEKGKRREKETTNVCTCLKWSSVQEIVKARTVHIVQVMSEDDENVYGQLVIDEKHSQESQESSEEELPDLEESSEEGPPAIEDETSLPNNEVTEEEPSSEEGPPAIGNETSLPNNEVRINSTMLVSIASASDSDISGDKLKCSAKQSPVTQQEYSEEDPLKIHISAGKPEEPDPEGSLSDKEEMMVIRDSKADSRGNVRRRKRITSSADDDELATDNMEVSTTHSDNAKSPREELEVIQITRKKKKKIVSFREKITLSKDAKKLQLVLEENSRLKEKVINLKMENREMKKQLKNVVKKKKVVRKTTPAVLETVEELEEKLEEMKKNKIGFYAKKGSFPIKESLKRSIKAKYPDEEQAIYKLLDELYSFEYMEIHKKTEKDATKGTSLKIAMDPNELKEIRDTMMNLYPTMKCGKGKLSTIVEKNITNKMNKTLKNPDTIKWLQDYNNLVKDLEKAIDAQGILEPNITISLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGJ4</accession>
    <name>E9HGJ4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="10">1.14.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_217996</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:20361"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:58373"/>
            <dbReference type="ChEBI" id="CHEBI:84492"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="10"/>
    <dbReference type="EMBL" id="GL732642">
        <property type="protein sequence ID" value="EFX69092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69092"/>
    <dbReference type="EnsemblMetazoa" id="EFX69092">
        <property type="protein sequence ID" value="EFX69092"/>
        <property type="gene ID" value="DAPPUDRAFT_217996"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_217996"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_8_0_1"/>
    <dbReference type="InParanoid" id="E9HGJ4"/>
    <dbReference type="OMA" id="SDVACII"/>
    <dbReference type="OrthoDB" id="655400at2759"/>
    <dbReference type="PhylomeDB" id="E9HGJ4"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008681">
        <property type="term" value="F:2-octaprenyl-6-methoxyphenol hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0274">FAD</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="11">
        <location>
            <begin position="30"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="11">
        <location>
            <begin position="339"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX69092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="459" mass="50845" checksum="EF529575D8221E0A" modified="2011-04-05" version="1">MKGFSFLSKYSNTIHNWRLNYSTASRSSHYDIIISGGGMVGFAMACRLGRSDCLANKRILLLESSNKKQLKLDSYNLRVSALNPGSKSLLESLGAWQHIEKTRFGSVKKMQVWDACSDAAVTFGKADLSEDIAWIVENDLVQDSLMKELDKIEQVEVQYKTKVTNYRLPKNADELVQVTLEDGSCLTTDLIIGADGFNSGLRQTIKTQYISYDYNQMAVVATLRISEGDENVTAWQRFLPTGPIALLPLNNEFSSLVWSTDKITAKSLLDLPPDVFTDRINQALWNNDDRNPMVQNVSERIFQMLKVCRVNSLEGSASDIRQLPPSVVEIKGRQAAFPLGLGHAVDYISNKAVLIGDAAHRVHPLAGQGVNLGFGDVIALNDAICEAVNNGADHGSSLYLKQYQSNRQMRNLPVMASVHGLHLLYGTTWTPLVMLRSIGLNVFDSLSSVKSFFTQRASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGS3</accession>
    <name>E9HGS3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_301173</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732643">
        <property type="protein sequence ID" value="EFX69067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69067">
        <property type="protein sequence ID" value="EFX69067"/>
        <property type="gene ID" value="DAPPUDRAFT_301173"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301173"/>
    <dbReference type="eggNOG" id="ENOG502RTCN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075165_4_1_1"/>
    <dbReference type="InParanoid" id="E9HGS3"/>
    <dbReference type="OMA" id="YKPAYSK"/>
    <dbReference type="OrthoDB" id="1194521at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003238380" evidence="4">
        <location>
            <begin position="18"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX69067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="144" mass="16259" checksum="DB2CC43FF8C6AE40" modified="2011-04-05" version="1">MKVIIALAVLAVVAVTAQYPSYPSYPAPAYPKPSYPKPSYDYAPIPYNFAYAVKDDYTYNDFGHQETSDGYAKTGSYYVLLPDGRMQTVNYKADENGYVADVSYKGEAQYPEYKPAYSKPAYPSYKPAYPEPAYPKPAYKPRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKB0</accession>
    <name>E9HKB0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_63671</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732667">
        <property type="protein sequence ID" value="EFX67866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67866"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_63671"/>
    <dbReference type="eggNOG" id="KOG4248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170758_0_0_1"/>
    <dbReference type="InParanoid" id="E9HKB0"/>
    <dbReference type="OrthoDB" id="1233552at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="118" mass="12931" checksum="32AE15A237B348D9" modified="2011-04-05" version="1" fragment="single">VPVIARDIQRQNRAPPNVPLSDAYLAGIPNKRRKLAEGNRPNTNPQLLLQETMERALRSANVSSAAVGEVTNVATANVEVGSALLPEIRRLGNARLDTDADFDAERFPNAERYFHGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKK6</accession>
    <name>E9HKK6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_261129</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732669">
        <property type="protein sequence ID" value="EFX67742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67742">
        <property type="protein sequence ID" value="EFX67742"/>
        <property type="gene ID" value="DAPPUDRAFT_261129"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_261129"/>
    <dbReference type="HOGENOM" id="CLU_1278771_0_0_1"/>
    <dbReference type="InParanoid" id="E9HKK6"/>
    <dbReference type="PhylomeDB" id="E9HKK6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="216" mass="24253" checksum="D5F9425076BD9267" modified="2011-04-05" version="1">MKYDESLLKNAVIAKDEQVNSHIKQIDEDIVPERQKNPCGGNVFKAAKDSSTNKKDLDETGLIMACCRHLIILQAILWVGHWIDGVGATVGEEQEQVNASMSLYGNRTKHMTPGTEAFSMELKDLLETFKLSETDLPGIKDRLKKKAASSARKNDDGPGPPCYLNDLEAQYSEMQILKKRREKTAKFSVHDGEILLPRYDIESSEDETSEDSSDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKN0</accession>
    <name>E9HKN0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_330784</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX67708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX67708">
        <property type="protein sequence ID" value="EFX67708"/>
        <property type="gene ID" value="DAPPUDRAFT_330784"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330784"/>
    <dbReference type="eggNOG" id="KOG2039">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_750643_0_0_1"/>
    <dbReference type="InParanoid" id="E9HKN0"/>
    <dbReference type="OrthoDB" id="117171at2759"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0030719">
        <property type="term" value="P:P granule organization"/>
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        <property type="term" value="P:piRNA metabolic process"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="164"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX67708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="369" mass="41975" checksum="FFBCC13361386B8B" modified="2011-04-05" version="1">MFLKVNVENEICKAIMIEPYGKHHGVRLLDSNNQLLANSLLGAEAQLHLRQALVRRRQIKSTSNGQCHRKNIIERASPEKDSANQELQEVYDAPGRSWPLTTHQQQLGHPEQSDVPRNQQIEVVHVNDPSSFYLQLFEYCTILTQLGTNNNTVYLDESRPTILDPQVGLACVVQYEEDNVWYRGQILKYCDPLGATVLFVDYGNTQLVPVKKIKSIEQNFRKQPPLAYQCTLDGVDASRDWTEKEKKKFEGRTMAKLLSATFTIRDSRGKYPVRLVEETKEANIAINEEFGAPNFTNIPTHSSRYTSRSVPYKPISVVVSWFPVVSVITDTFQFHLSPIDDVKAIGFRNSMVTVAKANWESGYRLLVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9HMA0</accession>
    <name>E9HMA0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DAPPUDRAFT_302216</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 14">Endoplasmic reticulum membrane</location>
            <topology evidence="3 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="GL732685">
        <property type="protein sequence ID" value="EFX67140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67140"/>
    <dbReference type="EnsemblMetazoa" id="EFX67140">
        <property type="protein sequence ID" value="EFX67140"/>
        <property type="gene ID" value="DAPPUDRAFT_302216"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302216"/>
    <dbReference type="eggNOG" id="KOG2124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007676_0_0_1"/>
    <dbReference type="InParanoid" id="E9HMA0"/>
    <dbReference type="OMA" id="TISHFCI"/>
    <dbReference type="OrthoDB" id="270107at2759"/>
    <dbReference type="PhylomeDB" id="E9HMA0"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PTHR12250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="8 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241880" description="GPI ethanolamine phosphate transferase 1" evidence="15">
        <location>
            <begin position="31"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="462"/>
            <end position="483"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="525"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="578"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="629"/>
            <end position="648"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="699"/>
            <end position="722"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="742"/>
            <end position="761"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="814"/>
            <end position="834"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="16">
        <location>
            <begin position="220"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="PigN" evidence="17">
        <location>
            <begin position="416"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFX67140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="889" mass="101515" checksum="82CF343D1970CAC2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HMH9</accession>
    <name>E9HMH9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_331440</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
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        <source>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <location evidence="2">Nucleus</location>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="146" mass="15973" checksum="CD84B6B2032E1EFD" modified="2011-04-05" version="1" fragment="single">RMACCADGIQRPTVAGIHAGPEGAYSISLSGGYEDDIDLGECFTYTGEGGRALKGTASDPKNLRTAPQSKDQTLTRGNLALSLNITTRKPVRVIRGSNLKNEFAPEYGYRYDGLYTVEKYWQCVGKSGFKVYKFALRRCPDQAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
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    <dbReference type="InParanoid" id="E9HPB4"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
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        <property type="entry name" value="Pro_4_hyd_alph"/>
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        </location>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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    </evidence>
    <sequence length="227" mass="26159" checksum="088301E6759E89B7" modified="2011-04-05" version="1">MEWLIDICQCVVRDLDKYGICVVDNFMGKERAESIHRSVVSMYHSGVFVEGETVGLKSNVRSDKITWVDGSENNCVHIAFLIAAVDTIIMNFMRFKKGAQLGSQLNIGGRTKAMISCYPGNGSHYVKHVDNPNQDGRCITTTYYVNKDWDAKETGGLLRIFPQTWSNKVVDIEPILDRMVFFWSDRRNPHEVQPSFRTRYAITIWYFDAKEREEAKLRNNQPLIKSH</sequence>
</entry>
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    <accession>E9HPV7</accession>
    <name>E9HPV7_DAPPU</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX66225.1"/>
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        <property type="gene ID" value="DAPPUDRAFT_332402"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_892145_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="312" mass="35339" checksum="97038ED7776DD8C9" modified="2011-04-05" version="1">MTCYVTAIHQLDAEKGKVNDMEAAEPVALPCVTTEDMFQEPTTETLLHIPPEKEMASESESQLRVEFEPNDMEVDELIGAPGEMTEEMLQENSEQTARETEMEGYLDPATYTDVIARVKLPSSSWMWQEDKVNKTLVCFSHSFSPDRKIVIKTISVVSMNKVELFLNGKQIFPRNVKTNFNVIEDLSNIIGAVEEGSSETTDIVDQPIDDSPTPDGFVDVEVEIKISDMLEVEVLHYADSSVPSLKFNQNLKHFERDPSIALLTMAVNSGQSQFAKWFKVGYHLNLIENVKLNYPQYLLEKPVFGDFRDCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9HQE9</accession>
    <name>E9HQE9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_302940</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="GL732719">
        <property type="protein sequence ID" value="EFX66024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66024"/>
    <dbReference type="EnsemblMetazoa" id="EFX66024">
        <property type="protein sequence ID" value="EFX66024"/>
        <property type="gene ID" value="DAPPUDRAFT_302940"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302940"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029404_3_0_1"/>
    <dbReference type="InParanoid" id="E9HQE9"/>
    <dbReference type="OMA" id="THNSPFA"/>
    <dbReference type="OrthoDB" id="826926at2759"/>
    <dbReference type="PhylomeDB" id="E9HQE9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PTHR12320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="54"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX66024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="316" mass="33913" checksum="5210CC5A6593C71A" modified="2011-04-05" version="1">MHSVYGRLLSRSIISGLYNCSSSNNSSGSSRTSVGNSSNETVSIKSKPKLVSAVAGFPKSFRSGKVHKGQIGDDAWLMKNIDSADILAVADGVGGWRDYGVDPSDFSLSLMRSIERITTVSSPCNFRNPVDLLSAAFRELLHSKRPITGSSTACILILEHESNNLFTVNIGDSGFLVVRKGRVVHKSEEQQHYFNTPFQLALPPPGHHGSALSDSPQSASQSQFAVQDGDVILLATDGVFDNVPTPILVAELSKLGGVKDQLCVQQTANSIALMARNLSFDGRYMSPFSQRARDYGIRAIGGKPDDITVLLATVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HSS4</accession>
    <name>E9HSS4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_333424</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732756">
        <property type="protein sequence ID" value="EFX65214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65214">
        <property type="protein sequence ID" value="EFX65214"/>
        <property type="gene ID" value="DAPPUDRAFT_333424"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_333424"/>
    <dbReference type="HOGENOM" id="CLU_1817719_0_0_1"/>
    <dbReference type="OrthoDB" id="365537at33208"/>
    <dbReference type="PhylomeDB" id="E9HSS4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX65214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="142" mass="16970" checksum="E12756F939B01D16" modified="2011-04-05" version="1">MSSSLLRFWMSFPLRIILPSVFRRNTQPFAVMKRPPYLQEPLHHIKSLLSSSILVQERPMVHRNNYRHWIQEVSSTGKIEILRPNLDWKKIWVETAVLQTNIRETLFLFNQRLLPTRTRCHRLDGWIKIANSAKRIQKPMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9HWA2</accession>
    <name>E9HWA2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotrans_gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_118647</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732908">
        <property type="protein sequence ID" value="EFX63978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63978">
        <property type="protein sequence ID" value="EFX63978"/>
        <property type="gene ID" value="DAPPUDRAFT_118647"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_118647"/>
    <dbReference type="HOGENOM" id="CLU_1207407_0_0_1"/>
    <dbReference type="InParanoid" id="E9HWA2"/>
    <dbReference type="OMA" id="FCERAGD"/>
    <dbReference type="PhylomeDB" id="E9HWA2"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="94"/>
            <end position="177"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="230"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX63978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="230" mass="26547" checksum="D4B87C784B2690D3" modified="2011-04-05" version="1" fragment="single">MADQDQADHGEFVLPHHGPGNNVHPPNFEQNVPQNVLGAPNVPPLIHVGNFRERDPPIFRGLPHEDVVEWIHQFQRVSAFNQWGPVQQQQLRHIEFSLEGVAATWLSGLQPRPQTYDGMIAALQEAFRHHNYAMELESRLRARKQKPDEPVMSYCYDMIYLCSRVDPGMTEERKLQFIFQNMEPALMQRVFPQMDQLTTNELFRRLQAHCQASLMAERSIPVNNIIPAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9HXS5</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_335437"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_736227_0_0_1"/>
    <dbReference type="OrthoDB" id="1498286at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX63456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="376" mass="41046" checksum="81AABB70521CD4AF" modified="2011-04-05" version="1">MSLLCFTGFSCGILSDELAITNPNYPNVDENAGNCDFRLLVNSHHVFQIRVEFRESRMFFLEKKIVYISIVDRLRVNYGRLKSPALENNLGGTQLIGRHQLSHVDFKINTKAVGFPFRSIGTIKTTGCVKSIDNSCTLALVYLVTKEILGSIKPNPLAFLPIGAGVGKKACDYLWISSRKKGVYPVIHTINCGSTFSERRGDFRHRIIMARMPSTSVKMMIFFHTGAPRHFNASDHGPGFRIDFEQIAPIELLSIYLTGHHVILEQYPYHWARQRHCPLRNWGRASGDKAMKAATRSTVVMGAGAGGFLVGGPVGAVTGGTAAGSGWDLVVAAATDGNEVNGIAKIIDDPTNVDSYFDAGTSLVRDAGVLAGLSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
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    <name>E9HY68_DAPPU</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX63310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX63310"/>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_268684"/>
    <dbReference type="HOGENOM" id="CLU_1403782_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="53"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="194" mass="21647" checksum="A8C254C3753F70BE" modified="2011-04-05" version="1">MENLMELEINPELEVETNEVPKYSYFCQKCGFLHHPWSMYYALCKNANKTSAVPEDDVSLKLDEEKQEEEDEESNDDDVSSESSPSSAEKQQVKRKNSLQRLEEAKRFKKMEKRGLPTVDSDDDLGDMTDSFSSGCSTYDSDDSDDWTGVSQHALRQDVEHQTTVSFLGASGISNEIAILQPGSSSDAGLEGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HYD1</accession>
    <name>E9HYD1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733139">
        <property type="protein sequence ID" value="EFX63250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63250">
        <property type="protein sequence ID" value="EFX63250"/>
        <property type="gene ID" value="DAPPUDRAFT_119383"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_119383"/>
    <dbReference type="HOGENOM" id="CLU_824559_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="337" mass="37542" checksum="CB504CE4FD4146F1" modified="2011-04-05" version="1">MRSVSLQARSSSGKRALMNQSSSSHPEIFMSDNKADSPPPSSSSTSANTSGSPSHSLKDNEANLQPSLLSTPSTYVQSCGSLSRRSSSPSHSSSLPSLSFNWLSNKPESHGFFLSLLDSFAVKWNFTESRTLSFPYGNFSQKLNRDISNIADIIPNGDKETSLSVLTVFRGFLAYITLLHDSYAESRQHDEIEFYGRLLIHFQKELPAHMPPVVGKYFYSTICRTYICTTCNESSDNFFEDSLWIICIGKTTHSWACCFQNYCKEQVIQRSCTSCSGESAIERITIHHLPPFPSSTDISLGYPGDGLTDELDVQCYVPWTSSDNPNVATYDIKMRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HYH1</accession>
    <name>E9HYH1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_119420</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
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                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
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                <person name="Tu H."/>
                <person name="Vos H."/>
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</entry>
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    <reference evidence="1 2" key="1">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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        </citation>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="49" mass="5519" checksum="89DA4EE491BA25A3" modified="2011-04-05" version="1">MNSAHRDVSHIAKYDGANFSLWKLGLFVLFEQMDLIDITTGALILPEQV</sequence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
    </feature>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_269697"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG2206">
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
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</entry>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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            <authorList>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Ye Y."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62117">
        <property type="protein sequence ID" value="EFX62117"/>
        <property type="gene ID" value="DAPPUDRAFT_337408"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_337408"/>
    <dbReference type="HOGENOM" id="CLU_052726_1_0_1"/>
    <dbReference type="InParanoid" id="E9I1L3"/>
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    <dbReference type="PhylomeDB" id="E9I1L3"/>
    <dbReference type="Proteomes" id="UP000000305">
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    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="187" mass="20369" checksum="B15A8936A7337940" modified="2011-04-05" version="1" fragment="single">MFADGKSLWESLAAIRSTPVSPTLPAPSVLLQGRNLRGNLPFLLAELQPKYVSSSVVRRELSTRQSQAAFVQAASPNTRASSLRIGQPVRALIGRRWLHGKVHSVCPEPQSYVVRLDDGRYFRRTRWAINVDRGTQSQPRSRDSTAMFSYRVPTIVQSAQSATGCETSGPASGVAGSPVIKAPTPVR</sequence>
</entry>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_120512"/>
    </dbReference>
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            <begin position="1"/>
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        </location>
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    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="187" mass="20903" checksum="98F220D45C15C1A1" modified="2011-04-05" version="1">MGPKRKEVDKIPDQNEERKMWRNRQNAESKKRVALKRKVDQYGECVAGDSITKGAGIGTTLNMEHGLFALIRDLFEDIILGSNDAETSSPKSPAALAFNSQRNRYAEEKLDVIEREAKEYNRKHAAKVAEEVATMISRGMCDVQASDVQASDIQATGLNGRHSGQCQGTFRPVKKIMLNVLYETETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9I268</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="7">MFS_1_like domain-containing protein</fullName>
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    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_302678</name>
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    <organism evidence="9">
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        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL733994">
        <property type="protein sequence ID" value="EFX61912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="TCDB" id="2.A.1.65.5">
        <property type="family name" value="the major facilitator superfamily (mfs)"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61912">
        <property type="protein sequence ID" value="EFX61912"/>
        <property type="gene ID" value="DAPPUDRAFT_302678"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302678"/>
    <dbReference type="eggNOG" id="KOG3762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013133_3_1_1"/>
    <dbReference type="InParanoid" id="E9I268"/>
    <dbReference type="OMA" id="GHINIIV"/>
    <dbReference type="OrthoDB" id="584059at2759"/>
    <dbReference type="PhylomeDB" id="E9I268"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="MFS_1_like" evidence="7">
        <location>
            <begin position="44"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX61912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="554" mass="61463" checksum="FBBA28C92EEE9B16" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2K9</accession>
    <name>E9I2K9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglut_core2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_338193</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734145">
        <property type="protein sequence ID" value="EFX61771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX61771"/>
    <dbReference type="EnsemblMetazoa" id="EFX61771">
        <property type="protein sequence ID" value="EFX61771"/>
        <property type="gene ID" value="DAPPUDRAFT_338193"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_338193"/>
    <dbReference type="eggNOG" id="ENOG502QS7Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_693670_0_0_1"/>
    <dbReference type="InParanoid" id="E9I2K9"/>
    <dbReference type="OMA" id="RICEVVQ"/>
    <dbReference type="OrthoDB" id="251112at2759"/>
    <dbReference type="PhylomeDB" id="E9I2K9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003238497" description="Transglut_core2 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Transglut_core2" evidence="2">
        <location>
            <begin position="119"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX61771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="398" mass="45810" checksum="FBC132396175BD32" modified="2011-04-05" version="1" fragment="single">MKLFVIAAVLAVAAAAPSSYATYEKTYEKDYKYPEITVTSQSDERNLDGSSKWRRENKTTLHYARDVLVKVRMSILDKKWRDFMAQPESQKSLFEGVALISQWSTMESGKGQTCLKDLERSIDEITDRVKQVLELDVGKVSRASTVELKKNNLKILDSINQVMFNELGFKNLLNFYTSDYNHYCNFQMAFETKEGCPAVLCAIYLEVARKMGIACEAVYCDHGDRRFIEDESSRSDRLMNRPKLLLRWKDSSGSEDDSIYIDVFRGGSLNQSSLYPSLREQPAASVDSVLFNMLHVLTHFLWERYEEHGLERMRDDLSFYVRLKCSMWPQDPNIITCYAEHCIGLGIQLDDAIQLLQNYIQSPEYNPFMGYLFSRSPSKMLEECISKLNEQKAEIAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9I3H5</accession>
    <name>E9I3H5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PI3K/PI4K catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_69496</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL734559">
        <property type="protein sequence ID" value="EFX61455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX61455"/>
    <dbReference type="EnsemblMetazoa" id="EFX61455">
        <property type="protein sequence ID" value="EFX61455"/>
        <property type="gene ID" value="DAPPUDRAFT_69496"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_69496"/>
    <dbReference type="eggNOG" id="KOG0904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002446_1_0_1"/>
    <dbReference type="InParanoid" id="E9I3H5"/>
    <dbReference type="OMA" id="CEAYNIV"/>
    <dbReference type="OrthoDB" id="204282at2759"/>
    <dbReference type="PhylomeDB" id="E9I3H5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052742">
        <property type="term" value="F:phosphatidylinositol kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014065">
        <property type="term" value="P:phosphatidylinositol 3-kinase signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036092">
        <property type="term" value="P:phosphatidylinositol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PTHR10048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="238" mass="27206" checksum="7B02EF8CC08CA916" modified="2011-04-05" version="1" fragment="single">GLDLRMMPYACLSTGKDVGMIEVVRQAKTVYGIQRQGGKLAAIQVDSTQLHKWIKEKNKGPKYEQAIETFTHSCAGYCVATFILGIGDRNPDNIMVNEDGSIFHIDFGHFLGHFKKKFGINRERVPFVLTEDFLYVISKGVENPRKSKAFQLFQELCGRAYLALRRHANLLITLFIMMLPTGIPELQSVDDIGYLRKTLAVEKTEEKALEYFQNQLFEAYGGAWTTKLDWFFHSVKHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61167.1"/>
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        </source>
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        </source>
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        </source>
    </evidence>
    <sequence length="1165" mass="131866" checksum="0144F9BE34DABDBD" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2869871_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9I669"/>
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    </dbReference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX60511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="64" mass="6720" checksum="C1AA4CEC74C67A8F" modified="2011-04-05" version="1">MTPGTKSGGGAEKDKHSAENDKNSAENDEIEVPKKSAETGGNLVQNGNDFTYIGVKSLSCNYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
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        </lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX60323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="153" mass="17414" checksum="BA3B89803D62430E" modified="2011-04-05" version="1">MGLNWLEQSRDPSSEKKKQRQCKRDRTESKLKSCEVAGGKELSYDGNETTTNAEPDNFPFCVFVPFPKAPRRYQSFCVEATKEISRFLFASFAFPSISIQPPASTLFLSPVYSPDSRRLAILWYRPGGLTRSKTRLKNLDRALQSLLVVMSXI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9I7P0</accession>
    <name>E9I7P0_DAPPU</name>
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    </protein>
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    <organism evidence="2">
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        <lineage>
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            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX59990"/>
        <property type="gene ID" value="DAPPUDRAFT_346021"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_190172_0_0_1"/>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="EFX59990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="64" mass="6935" checksum="FDFD3DDBC6E62553" modified="2011-04-05" version="1" fragment="single">DGSEQPMESLSLIDAVIPDVVASRQQQTEQTETTSGWEEETGVEIPASKSTVLRGHESEVFICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9I7T1</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DAPPUDRAFT_346214</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX59949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX59949">
        <property type="protein sequence ID" value="EFX59949"/>
        <property type="gene ID" value="DAPPUDRAFT_346214"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_346214"/>
    <dbReference type="eggNOG" id="ENOG502STNB">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_2661548_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003242110" evidence="1">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX59949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="76" mass="7623" checksum="B67E2B9D7FFA709B" modified="2011-04-05" version="1" fragment="single">MLIAALLLTAAIAGLAAAIAWGGPKDIPPLASINNPFKDVDYSNVPPAQRYTARDGTSLAWHGYTPAGGTGGTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9FR98</accession>
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        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_190268</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX41 subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90231"/>
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        <property type="protein sequence ID" value="EFX90231"/>
        <property type="gene ID" value="DAPPUDRAFT_190268"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_190268"/>
    <dbReference type="eggNOG" id="KOG0341">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_16_5_1"/>
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    <dbReference type="OMA" id="DMLDKKM"/>
    <dbReference type="OrthoDB" id="447398at2759"/>
    <dbReference type="PhylomeDB" id="E9FR98"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044113">
        <property type="entry name" value="DEADc_DDX41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="12">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="213"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="421"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX90231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="623" mass="69579" checksum="0DB2BAF300085284" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRG7</accession>
    <name>E9FRG7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_300174</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90201"/>
    <dbReference type="EnsemblMetazoa" id="EFX90201">
        <property type="protein sequence ID" value="EFX90201"/>
        <property type="gene ID" value="DAPPUDRAFT_300174"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300174"/>
    <dbReference type="eggNOG" id="KOG0889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000129_1_1_1"/>
    <dbReference type="InParanoid" id="E9FRG7"/>
    <dbReference type="OMA" id="NPIFAMD"/>
    <dbReference type="OrthoDB" id="7189at2759"/>
    <dbReference type="PhylomeDB" id="E9FRG7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016573">
        <property type="term" value="P:histone acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033317">
        <property type="entry name" value="TRA1/TRRAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="PTHR11139:SF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="9">
        <location>
            <begin position="2675"/>
            <end position="3247"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="3512"/>
            <end position="3723"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="10">
        <location>
            <begin position="3809"/>
            <end position="3841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="473"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2009"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX90201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="3841" mass="433187" checksum="14FDEC38764109D1" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRL1</accession>
    <name>E9FRL1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_189791</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="MEROPS" id="M12.A51"/>
    <dbReference type="EnsemblMetazoa" id="EFX89864">
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        <property type="gene ID" value="DAPPUDRAFT_189791"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_189791"/>
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    <dbReference type="InParanoid" id="E9FRL1"/>
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    <dbReference type="OrthoDB" id="343125at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0031012">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04272">
        <property type="entry name" value="ZnMc_salivary_gland_MPs"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.390.10">
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        <property type="entry name" value="ADAMTS_CR_2"/>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034030">
        <property type="entry name" value="ZnMc_salivary_gland_MPs"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAM_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="144"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX89864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="699" mass="76593" checksum="29C6D3F2B4E6E97D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9FTI5</accession>
    <name>E9FTI5_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_233207</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX89631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX89631"/>
        <property type="gene ID" value="DAPPUDRAFT_233207"/>
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    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_233207"/>
    <dbReference type="HOGENOM" id="CLU_2529713_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="84" mass="9729" checksum="E23AF6F2B381DC48" modified="2011-04-05" version="1">MSTAPVPSSSSSTAALPDNQAINKEGGRRRSNNTAININRRHNHHHHHRRQHPANPLTENPQQQQQQHHHHHHHNHHPLSRRRG</sequence>
</entry>
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        <name evidence="22" type="ORF">DAPPUDRAFT_44153</name>
        <name evidence="5" type="ORF">DAPPUDRAFT_67712</name>
    </gene>
    <organism evidence="29">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
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                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
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    <comment type="similarity">
        <text evidence="1 2">Belongs to the histone H3 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX86911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX87270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_235620"/>
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        <property type="gene ID" value="DAPPUDRAFT_235802"/>
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        <property type="gene ID" value="DAPPUDRAFT_43467"/>
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        <property type="gene ID" value="DAPPUDRAFT_43863"/>
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        <property type="protein sequence ID" value="EFX87388"/>
        <property type="gene ID" value="DAPPUDRAFT_43482"/>
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        <property type="protein sequence ID" value="EFX87398"/>
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        <property type="gene ID" value="DAPPUDRAFT_43602"/>
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        <property type="gene ID" value="DAPPUDRAFT_235586"/>
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        <property type="gene ID" value="DAPPUDRAFT_304645"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="PTHR11426"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HISTONE_H3_1"/>
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    </dbReference>
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        <property type="entry name" value="HISTONE_H3_2"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
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    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone" evidence="4">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX62753.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87270.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87367.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EFX87398.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87419.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87430.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87440.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX88870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="136" mass="15388" checksum="6FD8508EA50A0EEC" modified="2011-04-05" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9FW16</accession>
    <name>E9FW16_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Daphnia pulex</name>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88644.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="77" mass="8875" checksum="BD921943584590FB" modified="2011-04-05" version="1">MFRLIPLVMQIHSPNARKNLQPTDFDREFSPESSVEVDETIGKSRTQSTVLLAVVGFREKGPQFWAFILERPPPDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9FWJ4</accession>
    <name>E9FWJ4_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
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                <person name="Andrews J."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX88422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX88422"/>
        <property type="gene ID" value="DAPPUDRAFT_305444"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2796560_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX88422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="68" mass="7362" checksum="580C6786FFEC0B06" modified="2011-04-05" version="1">MHSLRFPIECVRMEPAALTVGSVSQGWIKIRSQGFASYGTTAPGHLARRGSHGIHSQLAFGPSKELWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXA6</accession>
    <name>E9FXA6_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">DAPPUDRAFT_234740</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Shaw J.R."/>
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                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_235035"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_97372"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="157" mass="17765" checksum="AD2817F1924DA071" modified="2011-04-05" version="1">MRESELVSETHRSHALEWRSDDTCLLCLIEIIRADSSSRLKIHRRFALATLNHRLNPDVTRPSFQQQDNSSCSSKNLAKLLQKNRNVSSQVLNTLLDSLTSVDVVDLAIEAVYRLYHHVLRDETVLDNVLTHCVQKSCVQCSSDYDATCLVLWLGGG</sequence>
</entry>
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    <name>E9G008_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_192739</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cai M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MN983136">
        <property type="protein sequence ID" value="QTX16301.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="SMR" id="E9G008"/>
    <dbReference type="STRING" id="6669.EFX87143"/>
    <dbReference type="EnsemblMetazoa" id="EFX87143">
        <property type="protein sequence ID" value="EFX87143"/>
        <property type="gene ID" value="DAPPUDRAFT_192739"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_192739"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="OMA" id="QCVIDDI"/>
    <dbReference type="OrthoDB" id="1259506at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="PTHR24070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX87143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QTX16301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="203" mass="23270" checksum="348C9312D01D73E4" modified="2011-04-05" version="1">MSKPGDRSSVAQTYKIVVVGGGGVGKSAITIQFIQSYFVTDYDPTIEDSYTKQCVIDDVVAKLDILDTAGQEEFSAMREQYMRSGEGFLLVYSVADRSSFDELPRLHRQILRVKDRDEFPMLMVANKADLQHQRMVSSDEGHSLARQLKVPYLECSAKLRMNVDLAFHELVRLIRRFQALERPLTSSKDQRQARKRRKMCMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G086</accession>
    <name>E9G086_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_235575</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX86858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86858">
        <property type="protein sequence ID" value="EFX86858"/>
        <property type="gene ID" value="DAPPUDRAFT_235575"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_235575"/>
    <dbReference type="HOGENOM" id="CLU_2724795_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX86858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="72" mass="8115" checksum="5635E274E5AC8CEA" modified="2011-04-05" version="1">MLYAVGIQLFAPSADAESFSACIRANVSNVDNTWLEFLDRMIGYEMCQQAIKQNCALMSAPPLIDLQRRAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9G0C6</accession>
    <name>E9G0C6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_43728</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87428"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_43728"/>
    <dbReference type="eggNOG" id="KOG3804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037998_1_1_1"/>
    <dbReference type="InParanoid" id="E9G0C6"/>
    <dbReference type="OMA" id="SLWLHWA"/>
    <dbReference type="OrthoDB" id="827924at2759"/>
    <dbReference type="PhylomeDB" id="E9G0C6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001709">
        <property type="term" value="P:cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033077">
        <property type="entry name" value="Pokkuri"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR11849"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF201">
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    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ETS_DOMAIN_3"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
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    </dbReference>
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    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
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        <location>
            <begin position="161"/>
            <end position="242"/>
        </location>
    </feature>
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        <location>
            <begin position="71"/>
            <end position="155"/>
        </location>
    </feature>
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            <begin position="73"/>
            <end position="107"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX87428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="242" mass="26903" checksum="6A4080C0B12D2AD7" modified="2011-04-05" version="1" fragment="single">DPRTWAREDVVTFLRWCEREFDLPGLDLDKFQMNGKALCLLNKSDIAERAPGSGDVVHNALQLLLPAAANNAHHHHHSNQAGSNSGSQSDSEENDSVQDNSPARSPAPSTPIHLVPPPMSPLATTFSSAASSKNMDKDPLATTPDRNGGGGDGLDSGSNGRLLWDFLQQLLNDPSQRYSHYIAWKNRETGVFKITDPAGLARLWGIQKNHPSMNYDKMSRALRYYYRVNILRKVQGERHCYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9G2C3</accession>
    <name>E9G2C3_DAPPU</name>
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    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX86223.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2796580_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX86223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="68" mass="7216" checksum="8C87B38DA0470336" modified="2011-04-05" version="1">MSQGTYKRHGSVTGGRCATALESASSFGFSAGDAPADGAEQIDEEDDDDDDDDDESKSEGRREQGQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3C2</accession>
    <name>E9G3C2_DAPPU</name>
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        <submittedName>
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    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_313511</name>
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    <organism evidence="3">
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        <name type="common">Water flea</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1705092at2759"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX85746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="455" mass="49973" checksum="8FD96684C86699A2" modified="2011-04-05" version="1">MNNDSTCNQPSSLTVDSLSYKELQVLAMSLSLPGKMKQGVLVEAIKARQSQNEQAVAMILEANRQRRILRREQQLRSQQQQLLKLKDESKRAPKFLSRSKMKRSASEMDPAAYIFNAETFKRSKLAAALSQQSRGPASFSFSSLTTGPTSLTIRKEHQYQASAAVMGGCSTWDQQQPIVSDSLFVGLPSMHNMMHQKALPDLSKELSILPLLSDCSNSGGSGVNSSINEDLCCSVGSVSANSTSSWQSGGSSDNLHPLPQSSFESCDSGWMGADDSYDLNTWKNLQNIRLNNNGLENTSLPTNSSSNYFDPATPAPDMFMNNDDLYSPDDFISSPVTGSNYNTDFELPLESSSGYQDVNIKQNPSTSTWCEPFIQQSAQQFPQSSMQNVCSTITSESHATSTNDCCYDFDCYQLGGPFFRIQRPGNPTSVFVPSGRSLTLSTFCNMLPRVASYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3E1</accession>
    <name>E9G3E1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_237230</name>
    </gene>
    <organism evidence="5">
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        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85757"/>
    <dbReference type="EnsemblMetazoa" id="EFX85757">
        <property type="protein sequence ID" value="EFX85757"/>
        <property type="gene ID" value="DAPPUDRAFT_237230"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_237230"/>
    <dbReference type="eggNOG" id="KOG1363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028119_0_0_1"/>
    <dbReference type="InParanoid" id="E9G3E1"/>
    <dbReference type="OMA" id="RNQQWKG"/>
    <dbReference type="OrthoDB" id="845154at2759"/>
    <dbReference type="PhylomeDB" id="E9G3E1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030433">
        <property type="term" value="P:ubiquitin-dependent ERAD pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd14413">
        <property type="entry name" value="UBA_FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01771">
        <property type="entry name" value="UBX_UBXN3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033043">
        <property type="entry name" value="FAF1-like_UBX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044541">
        <property type="entry name" value="FAF1_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="586"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="498"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX85757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="666" mass="75120" checksum="F2EC6434775586EC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3I6</accession>
    <name>E9G3I6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PBPe domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_98390</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85981"/>
    <dbReference type="EnsemblMetazoa" id="EFX85981">
        <property type="protein sequence ID" value="EFX85981"/>
        <property type="gene ID" value="DAPPUDRAFT_98390"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_98390"/>
    <dbReference type="eggNOG" id="KOG1052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007257_4_0_1"/>
    <dbReference type="InParanoid" id="E9G3I6"/>
    <dbReference type="OrthoDB" id="188544at2759"/>
    <dbReference type="PhylomeDB" id="E9G3I6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236626" description="PBPe domain-containing protein" evidence="3">
        <location>
            <begin position="36"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="4">
        <location>
            <begin position="169"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX85981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="366" mass="40792" checksum="96DE2297E33705E4" modified="2011-04-05" version="1">MHILRRCQNLVALTRSKLLILLQVLALLLIKSVDSTTETDLRGLHFNIIAFQSPPFDAVIRGPNGTLNVSGANVVVHNWLAQRLKFTIAYLPLNNTLIDKLGTHEGAFYTLMNDKNVDGLLVAFYLTMDRVERFDYTSSSWSEGFSFVAPRPGEESRLFAFIGPFQPMVWMSVFISVFFVIATMTVFTWLYSRRRRPVNTVDTTGNTELKNVLSVQRSILPFIGSHMIYVINTMTNQGGREFSSHTSFRVLAGAWVLCAMVLVNSYTGIVTSSLTTPKLKPPMNTLEELAASNEVKIVIRSDTSTGVQILQATSGIFKVLGDQVRSEPDRIFTDPFKLAAKLGTGHFAFPFNFGDVGDRHSSFCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3P2</accession>
    <name>E9G3P2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_309001</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85948"/>
    <dbReference type="EnsemblMetazoa" id="EFX85948">
        <property type="protein sequence ID" value="EFX85948"/>
        <property type="gene ID" value="DAPPUDRAFT_309001"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309001"/>
    <dbReference type="eggNOG" id="KOG2361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029724_0_2_1"/>
    <dbReference type="InParanoid" id="E9G3P2"/>
    <dbReference type="OMA" id="PAKWWNL"/>
    <dbReference type="OrthoDB" id="987359at2759"/>
    <dbReference type="PhylomeDB" id="E9G3P2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytosine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="PTHR22809"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX85948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="315" mass="36572" checksum="BB4531E7E40D0D07" modified="2011-04-05" version="1">MEESSDNSESKRPQFGTRHLSDPQNVFQHNAWDNVVWGDEQMKEAEAKLKLNSSSFMTEEAALKYEKEASQFWDTFYSTHENKFFKDRHWLFTELPELCNEQPTENVSETEVNTTGFPCQSAGFRIMEVGCGTGSTVFPLLEANTLKKSFVYCCDFSPKAVELVKSNPEYDPTKCHAFVCDLSEDNITFPFPENSLDIILVIFVLSAISPEKFSSTIKQLSRQLKPGGRIFFRDYGRYDMAELRFKPGKCISEHFFVRGDGTRVYFFSQDELRKLFEESGLVEEQNVIDRRLLVNRGKQLTMYRVWIQCKYRKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3U1</accession>
    <name>E9G3U1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_309007</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_309007"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309007"/>
    <dbReference type="HOGENOM" id="CLU_2690354_0_0_1"/>
    <dbReference type="OrthoDB" id="1451261at2759"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX85929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="74" mass="9013" checksum="4719C271F1E42B74" modified="2011-04-05" version="1">MIKLAYGVEHDFRNFRYWYRMIEDNPHPQTVSYFHLSLSSISQLHSLLPYELQNAKCRCLEDIKFFLLLYILSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3Z4</accession>
    <name>E9G3Z4_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_98530</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_98530"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_98530"/>
    <dbReference type="HOGENOM" id="CLU_1908814_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX85900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="133" mass="14629" checksum="505E00D737E5AC2E" modified="2011-04-05" version="1">MWWGSVENEGGRRGRSRHVDTTFGAALCSGSLRRLNGCPFVSLVSDSITHGRCKVSINIDASHALTLHLAGHRLIKVTKNINPSDEIVGGDRSTPAPAKLVYLVVMTLGYVGWLWPQTCNKEKVTWCKQTAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9G5V4</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX84831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_671330_0_0_1"/>
    <dbReference type="InParanoid" id="E9G5V4"/>
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    <dbReference type="PhylomeDB" id="E9G5V4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EFX84831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="471" mass="53467" checksum="8EF7B41E868B6ADB" modified="2011-04-05" version="1">MFVECTTVSTAVQKATQLPNLETQRVQHCRRAGQFACPSRLKVLGNITPNPSNVNLKKERPVCISFTFEGHVNYGVVLLLGVESLTVGSTTCTDVSWSLNCGVVLLLVAVLKYYTTEASEYYTTIYAAARCITKEPEYYITHPQQRLICMSFTLEGRGDHYENLSMRWFNSGAVLLFGVVSLKVGSTTGLLMSSGHGGDKATAVKEYYTTPPPYYATKDTTTEATKFYVAQAYNTAAAPSYYVELKNYTKAAVDYITTYATPSYYDEASNYYTEEAIFYYTEEPKFYSAPSYYQTEAPVCYTKATEYYTTTKRKLWVYRCLLAEYYTTKAAEYYTTKAAEYYTTKAAEYYTTKAAEYYTTKAAEYYTTKAAEYYTTKAAEYYTTKAAEYYTTKAAEYYTTKAAEYYTTTKAAANSYYTTKATENYTTSYAATTYYTEAPKFYSVLSYHTIKEAEHYTINASATYYMEISKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
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    <name>E9G8U1_DAPPU</name>
    <protein>
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            <fullName evidence="9">Uncharacterized protein</fullName>
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    <organism evidence="10">
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84034"/>
    <dbReference type="MEROPS" id="C19.972"/>
    <dbReference type="EnsemblMetazoa" id="EFX84034">
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        <property type="gene ID" value="DAPPUDRAFT_187802"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9G8U1"/>
    <dbReference type="OMA" id="HVYINLE"/>
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    <dbReference type="PhylomeDB" id="E9G8U1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="PTHR21646:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="52"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="155"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX84034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="495" mass="56893" checksum="D2D82980A16871B8" modified="2011-04-05" version="1">MGTEKSDIKRKHEDFDDEDEPVVKTREPIAKSRLCPYLDTINRTVLDFDFEKLCSVSLTRINVYACLVCGKYFQGRGPSTHAYLHSVGEGHHVFLNLHTLRFYCLPDNYEIIDSSLDDIKYVLNPTFKKANIAVLDVIDKVSRSCDGTLYRPGVFGLNNIKANDYCNVVLQALSHVVPLRDYFLREENYIGIKRPPGDNNVILVQRFGELIRKLWNPRNFKAHVSPHEMLQAVVLCSKKKFQITSQGDPVEFLSWFLNALHLALNGTKKPTSSIIYKSFLGAMKIHSQRIPPIDATDTEKDALMLTAEYVETFVDSPFLFLAADLPPPPLFKDEFRENIIPQVSLFALLSQFNGVQQKEYKTYKENFLKRFELTKLPRYIILNIKRFTKNTFFIEKNPTIINFPIRGVDFGDILGADVRAKHGCTTYDLLANIVHDGEPTKGTYRVHILHKATGKWFEMQDLHVTEILPQMITLTEAYIQIWEQSTERSDVEMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9G936</accession>
    <name>E9G936_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SIFamide receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_23370</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84166"/>
    <dbReference type="EnsemblMetazoa" id="EFX84166">
        <property type="protein sequence ID" value="EFX84166"/>
        <property type="gene ID" value="DAPPUDRAFT_23370"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_23370"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009579_6_0_1"/>
    <dbReference type="InParanoid" id="E9G936"/>
    <dbReference type="OMA" id="ITSAYTH"/>
    <dbReference type="OrthoDB" id="1308959at2759"/>
    <dbReference type="PhylomeDB" id="E9G936"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F1_2" evidence="8">
        <location>
            <begin position="25"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX84166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="299" mass="33649" checksum="CB9783EBDC843A1F" modified="2011-04-05" version="1" fragment="single">YRYNVWVSGALCTAYGLVFCAGLIGNLLVAVVVLRGSRTMRRCVTNLFLVNLAFADLLVVLACLPFTLVAHLIYPWVMGSIICKLVPYLQGVSVSASVYTLVAVAVERYWSISSPWKKRLSSKCCRVIIGLIWIGSAIITLPWLVVFRQDYVSETLVCTEIWPDPLMGDTYYAVAHLTLCYVLPLVIIAACYALICRQIWCRQIPGSGEQGPPNHHHRAKIRALRMLGVVVAAFALSWFPLYATFTRLKFAKSMSEPEAEFWEMIMPVAQWLSSANSCVNPLLYHFLDPRFRSGFKQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAM6</accession>
    <name>E9GAM6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_230683</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83509"/>
    <dbReference type="PRIDE" id="E9GAM6"/>
    <dbReference type="EnsemblMetazoa" id="EFX83509">
        <property type="protein sequence ID" value="EFX83509"/>
        <property type="gene ID" value="DAPPUDRAFT_230683"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230683"/>
    <dbReference type="eggNOG" id="KOG3090">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <location>
            <begin position="40"/>
            <end position="201"/>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="304" mass="33660" checksum="DF4AFED37E350071" modified="2011-04-05" version="1">MAQSKLNDLAGRFSNGPKGLGTGLKLLALAGAAAYGVSQSMYTVEGGHRAIIFSRLGGVKNDTYPEGLHLRLPWFQYPIIYDIRSRPRKISSPTGSKDLQMVNITLRVLSRPDAALLPDVYRNLGLDYDEKVLPSICNEVLKSVVAKFNASQLITQRQQVSLLVRRELTERARDFNIILDDVSITELSFSKEYAAAVESKQIAQQDAQRAAFFVEKAYQERQQKIVQAEGEAEAGKMMGVAIGINPGYLKLRKIRAAQNIARTIAASQNRVYLNADSLMINVSDVSFDERIATVGNLKKPEVKK</sequence>
</entry>
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    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX83502.1"/>
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    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_240028"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX83502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="59" mass="6570" checksum="41B08A9C703269C8" modified="2011-04-05" version="1">MPTSHYTTTYASVGYYTINAPVNYITTYVAPSYYTDALNYRHPSVAASNLQHFDLVGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBB9</accession>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732538">
        <property type="protein sequence ID" value="EFX83186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_302057"/>
    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="176" mass="19882" checksum="350B9645E5782CE1" modified="2011-04-05" version="1">MATNTCPKSEELIPTASKNMEIAAGKRNLTDNCLYCGERLDPTKLVFQVNLLTLTVSCQSCDKKNYFGKIRQIPMPLPSPPVIKRLAGYQLRERKQPEYQNPFFDSSSSNKESSEEESEESPLTTTTENQECVSSSNRLTPEEISELMCLEAQANRLKREKLLNRKNPESNTSNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBK3</accession>
    <name>E9GBK3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_302123</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732538">
        <property type="protein sequence ID" value="EFX82967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82967">
        <property type="protein sequence ID" value="EFX82967"/>
        <property type="gene ID" value="DAPPUDRAFT_302123"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302123"/>
    <dbReference type="eggNOG" id="ENOG502S58G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051234_1_0_1"/>
    <dbReference type="InParanoid" id="E9GBK3"/>
    <dbReference type="OMA" id="APRFTHE"/>
    <dbReference type="OrthoDB" id="1451134at2759"/>
    <dbReference type="PhylomeDB" id="E9GBK3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="35"/>
            <end position="110"/>
        </location>
    </feature>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82151">
        <property type="protein sequence ID" value="EFX82151"/>
        <property type="gene ID" value="DAPPUDRAFT_49070"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_49070"/>
    <dbReference type="eggNOG" id="KOG1584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027239_1_1_1"/>
    <dbReference type="InParanoid" id="E9GDV9"/>
    <dbReference type="OMA" id="RGMENAN"/>
    <dbReference type="OrthoDB" id="780670at2759"/>
    <dbReference type="PhylomeDB" id="E9GDV9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051923">
        <property type="term" value="P:sulfation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransfer_1" evidence="1">
        <location>
            <begin position="69"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX82151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="341" mass="39915" checksum="67471841DE118770" modified="2011-04-05" version="1">MSRFDDEKFKQLQLKVKFNVIPKTRLKKFGKLFDGYPTGLVKSEPGGFVMPPTYGENAEKIYRMKPRTEDVWLLTFPKCGTTWTSELLWLLENDCNFETAAKIPLHSRAPFLEYIRSLMPYLSAMSGPMKNYLMTVDKVEKLPSPRVIRPHLPFYLLPPELLDTSKVVYVARNPKDVIVSYYFHHKLIKVHGYTGTLDEFAEFFINDEVVYAPFFPHIMDAWSKRHHPNMHFMFYEDMKKDLRGEIEKVATFLGKSYSDEQLGKLTEHLKFENFQKNESVNNESGKKFGAMNEDGRFIRNGKTGDWKNHFSPELNSRIDEWIEKNLAGTDLKFVTELEHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEH4</accession>
    <name>E9GEH4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_241527</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82312">
        <property type="protein sequence ID" value="EFX82312"/>
        <property type="gene ID" value="DAPPUDRAFT_241527"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241527"/>
    <dbReference type="HOGENOM" id="CLU_1058681_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240921" evidence="2">
        <location>
            <begin position="21"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX82312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="263" mass="30100" checksum="039FF0D284BC34D8" modified="2011-04-05" version="1">MSPTTMLTVVFNWIISWFLGEDYQNLVKPKPTGPTNPGQKPNLPPPPIPVTPATGLFEGDCGDPYYSYPKHVPIQLNNQPPSQRYARNEQFHRQLLAPPQRPDMFYVEMQNRFRQMEEQQKIDQREIYELRINAVKMQAELDEIRSNLNLIFLPQPAPMGWTAPHPKKDGSAFDSPPTTTTSVKPESYYSNAALASSKTQNDLSPRMVDLIDVNNWGPIMPRPNSNERNNVHPPFVFQMAPPKAPPTIQKSTGQIRNQYRRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEU2</accession>
    <name>E9GEU2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_302792</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732541">
        <property type="protein sequence ID" value="EFX81896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81896"/>
    <dbReference type="MEROPS" id="M16.973"/>
    <dbReference type="EnsemblMetazoa" id="EFX81896">
        <property type="protein sequence ID" value="EFX81896"/>
        <property type="gene ID" value="DAPPUDRAFT_302792"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302792"/>
    <dbReference type="eggNOG" id="KOG0960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_4_0_1"/>
    <dbReference type="InParanoid" id="E9GEU2"/>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="OrthoDB" id="638125at2759"/>
    <dbReference type="PhylomeDB" id="E9GEU2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="57"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="209"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX81896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="478" mass="52677" checksum="B3079BE64F7180E7" modified="2011-04-05" version="1">MASKILRVSPMLLKLANGSSLVKNSTRLRATSAALNYEQTLVNVPPTRLTVLDNGLRVASEDSGAPTATVGIWIDAGSRNETEANNGVAHFLEHMAFKGTGKRSQTDLELEIENMGAHLNAYTSREQTVFYAKCLSEDVGKSIEILSDIIQNSKLGEPEIERERGVILREMQEVETNLQEVVFDHLHSTAYQGTPLGRTILGPTQNIKSLSRADLVTYIKNNYGASRMVLAAAGGIKHEDLVELAQKSLGSLSNSFDAKITAPTKCRFTGSEIRVRDDDMPFAHIAIAVEGCGWTDADNFPLMVANTIIGSWDRSQGGGANLASNLASYSAQSNLCHSFQSFNTCYKDTGLWGIYFVCEPMKCEAMLYNIQSEWMRLCTAPTPTEVERAKNLLKTSMLLQLDGTTPVCEDVGRQMLCYGRRLPLHELEARIDSVTPADVRDACNKYIYDRCPAVAAVGPVEALPDYNRIRSSMYWLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9GF48</accession>
    <name>E9GF48_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_49705</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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    <dbReference type="Pfam" id="PF00629">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX80667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="344" mass="37887" checksum="577FC63010C9DBA4" modified="2011-04-05" version="1">MLKLIFFLFSVRLLQLLIGGSSAASCPPCPQSDPAVAKERLNNDFEINGVFPWVDESQIGVRWQIENKTSPWELGNVAPQPLTGRNYLRVHRGQSFSSFGVAILRSQTFRLPACQNDFSFSFWIRSKWPQFTNLELYMSNNGNERLLISLYNYSSITNGIWRSQSVLLECESASNVSLVFYAYCGTEKEDAVAIDDLRFSSKQLTVTSPFWTTTSKSPTTKSAGKLLTEPTTEPQNTYTTDTMTDPPTDPPTDPTINPTTNSTTQTTPSTTTTDPPTDPPTNPTTDPTTDPPTDPPTEPTTQTTPSMTTPTTTTNPTTNPTTQTTPSTTTSIEPCSCPTVEPCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIR7</accession>
    <name>E9GIR7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_303814</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732546">
        <property type="protein sequence ID" value="EFX80843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80843"/>
    <dbReference type="EnsemblMetazoa" id="EFX80843">
        <property type="protein sequence ID" value="EFX80843"/>
        <property type="gene ID" value="DAPPUDRAFT_303814"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303814"/>
    <dbReference type="eggNOG" id="ENOG502QRZ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_853268_0_0_1"/>
    <dbReference type="InParanoid" id="E9GIR7"/>
    <dbReference type="OrthoDB" id="1301963at2759"/>
    <dbReference type="PhylomeDB" id="E9GIR7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043441">
        <property type="entry name" value="Tjap1/BEGAIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28664">
        <property type="entry name" value="PTHR28664"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX80843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="326" mass="37404" checksum="4FD0C7960A5C161B" modified="2011-04-05" version="1">MEETETVIDIIDISRELYDLKNKYERLKEGHRKLLIVNQNLEEKLLQNINKYETEKFSMVHTISSLNHQLEELQRINKKLATENERFKLDISVAIQLLHCKPSSFSECKLENLPQEFQDKAKFHMQQEFLPRYKPEKKGKVIRVPISAFPSTTVIYSIPDDNDDDGEDINTNTTVPVETMAKVLNERQLELYNQSMNGSSLQLNCNNGLHSSHSMSFMDNGLQYVDHGTQTYPNFIGEREKTRNTCIFCQGEPSTNRPESIESQPNLPLGDPKVFVYTESEISPVTVRSTSNSFKKNSANTHRRKVLANSSSVSPSYSRSSMETDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9GLE8</accession>
    <name>E9GLE8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein adenylyltransferase Fic</fullName>
            <ecNumber evidence="6">2.7.7.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">De-AMPylase Fic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DAPPUDRAFT_212397</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O = AMP + H(+) + L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:55932"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54292"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:13846"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fic family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.n1" evidence="6"/>
    <dbReference type="EMBL" id="GL732551">
        <property type="protein sequence ID" value="EFX79501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79501"/>
    <dbReference type="EnsemblMetazoa" id="EFX79501">
        <property type="protein sequence ID" value="EFX79501"/>
        <property type="gene ID" value="DAPPUDRAFT_212397"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_212397"/>
    <dbReference type="eggNOG" id="KOG3824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040460_0_1_1"/>
    <dbReference type="InParanoid" id="E9GLE8"/>
    <dbReference type="OMA" id="CTEMTLD"/>
    <dbReference type="OrthoDB" id="1057856at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fido" evidence="16">
        <location>
            <begin position="171"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="253"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="285"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for autoinhibition of adenylyltransferase activity" evidence="14">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="15">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFX79501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="352" mass="40201" checksum="D7059542AAB1A40C" modified="2011-04-05" version="1">MHKSGKHSKALKLFSHALALNPEHPDILNHYGEFLEETERNLLDADYHYSRALTFSPNHMRALENHQRTSPIVDELDNNLLKRIDQKRDDLLNTPDSSSGLRRIKKEAYFQYIYHTLGIEGNTMSLAQTRTIVETRMAVGGKSIMEHNEVLGLDAALKYINSTLVHRIGAITFEDILEIHRRVLGFVDLFEGGRLRSTQVFVGNHIPPGPSEVQLLMKDFVRWLNSAESLSQHPIRFAALAHYKLVYIHPFSDGNGRTSRLLMNLILMQSGYPPVIIRKQDRAKYYDYLQQANEGDVRPFIRFIAHCAEQTLDVYLWATTEHRTSIAELAQEGQEDDGKTIIVDQHNCCVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9GMM0</accession>
    <name>E9GMM0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_104556</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732553">
        <property type="protein sequence ID" value="EFX79267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79267"/>
    <dbReference type="EnsemblMetazoa" id="EFX79267">
        <property type="protein sequence ID" value="EFX79267"/>
        <property type="gene ID" value="DAPPUDRAFT_104556"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_104556"/>
    <dbReference type="eggNOG" id="KOG0355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1679712_0_0_1"/>
    <dbReference type="InParanoid" id="E9GMM0"/>
    <dbReference type="PhylomeDB" id="E9GMM0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX79267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="157" mass="18241" checksum="93C3FB2272DC8519" modified="2011-04-05" version="1">MNAFSKEKLPLYPAFIRSLMNFNATDIKIKDNSMDTIRVDIDLKSNIIKIFYNGEGIPVVEHEEAKMYVPSLIFCSLHPSFNICDEEEIITGYRNRFDAKIANIFSTFFVLEIASKEQGKRFKQEWRTNMTKDNIPEIRSYSGSSFTEITFSSISFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E9GMU1</accession>
    <name>E9GMU1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_52799</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="EMBL" id="GL732553">
        <property type="protein sequence ID" value="EFX79152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79152"/>
    <dbReference type="EnsemblMetazoa" id="EFX79152">
        <property type="protein sequence ID" value="EFX79152"/>
        <property type="gene ID" value="DAPPUDRAFT_52799"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_52799"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_0_1_1"/>
    <dbReference type="InParanoid" id="E9GMU1"/>
    <dbReference type="OMA" id="CATTHKV"/>
    <dbReference type="OrthoDB" id="372408at2759"/>
    <dbReference type="PhylomeDB" id="E9GMU1"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070552">
        <property type="term" value="C:BRISC complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070905">
        <property type="term" value="F:serine binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002082">
        <property type="term" value="P:regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="10">
        <location>
            <begin position="10"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
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</entry>
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    <accession>E9GN44</accession>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <location>
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        <source>
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        <source>
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</entry>
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                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
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                <person name="Detter J.C."/>
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                <person name="Gerlach D."/>
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                <person name="Krijgsveld J."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
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    </dbReference>
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    </evidence>
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    <sequence length="1288" mass="144995" checksum="FC683F77B4EA0487" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Basu M.K."/>
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    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="EMBL" id="GL732559">
        <property type="protein sequence ID" value="EFX78026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78026"/>
    <dbReference type="EnsemblMetazoa" id="EFX78026">
        <property type="protein sequence ID" value="EFX78026"/>
        <property type="gene ID" value="DAPPUDRAFT_320881"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_320881"/>
    <dbReference type="eggNOG" id="KOG3714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017286_4_0_1"/>
    <dbReference type="InParanoid" id="E9GRB1"/>
    <dbReference type="OMA" id="MNEYHEN"/>
    <dbReference type="OrthoDB" id="681837at2759"/>
    <dbReference type="PhylomeDB" id="E9GRB1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX78026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="202" mass="23327" checksum="72262782334BC4A7" modified="2011-04-05" version="1">MAIPNKNKGRPLSEDELQIVSSFYESDEYSRMQLASDQRKVIAFGMNEYHENTCIKFVPRTSEKNYIRIYKKGSGCSNVSLDDGCVSRIRPGIVLHELMHAAGFFHEHTRPDRDTFVRINFENILEKHVFNFNTNDASKVTTLGLPYDYDSVMHYSRYAFAVDRTRPTITPVPNENVEIGNRRKFSCLDLLKLNALYCSEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9GRS9</accession>
    <name>E9GRS9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tubulin-specific chaperone D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_247122</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCD family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732560">
        <property type="protein sequence ID" value="EFX77828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77828"/>
    <dbReference type="EnsemblMetazoa" id="EFX77828">
        <property type="protein sequence ID" value="EFX77828"/>
        <property type="gene ID" value="DAPPUDRAFT_247122"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_247122"/>
    <dbReference type="eggNOG" id="KOG1943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055019_0_0_1"/>
    <dbReference type="InParanoid" id="E9GRS9"/>
    <dbReference type="OrthoDB" id="79003at2759"/>
    <dbReference type="PhylomeDB" id="E9GRS9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034333">
        <property type="term" value="P:adherens junction assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="Tubulin_specific_chaperoneD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="PTHR12658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFCD_C" evidence="3">
        <location>
            <begin position="330"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX77828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="415" mass="46339" checksum="22F6BD43B0B98B77" modified="2011-04-05" version="1">MPISNSGDLFVAQYEEYRPHLIQHLVDRKVIHWDTVIRQLTSQALHQMTFLDPESMKLILSTQILPRCTNPELYLRHRSILASGKVISALCQVAKDHQRRLPEELGDAAMESITQTCIYILEERFWRSFGGDPMRIAVCHFIQDLSSGGFPLLDAVVDRWLKALRECLASADSNVQQSAISAVTALIGDYFRHQPVEKLTALLNHFLPEVTSNNQQARVGNALALGSMPRFLLTVSLPKVIQQLCTCALITDKTLQWAESRKNALTALSLVCTTVGIAPSSPVKMTDGLIFIYFEISGVDQVTLAGIFRTFIDGFEDYTVDSRGDIGAIVRESAMYSIQVLTNTSQPDLLEADLIRSLEELRSIIPPPPLDISTEKECFDLWMKVIRLDTYRKAVITGLVSSIGSLTESLFTPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GSW8</accession>
    <name>E9GSW8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_106149</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732562">
        <property type="protein sequence ID" value="EFX77504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77504">
        <property type="protein sequence ID" value="EFX77504"/>
        <property type="gene ID" value="DAPPUDRAFT_106149"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_106149"/>
    <dbReference type="eggNOG" id="ENOG502SR5B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088037_0_0_1"/>
    <dbReference type="InParanoid" id="E9GSW8"/>
    <dbReference type="OMA" id="WEARRIG"/>
    <dbReference type="OrthoDB" id="1535664at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX77504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="282" mass="32834" checksum="A56AF2167C9F8DDD" modified="2011-04-05" version="1">MASAETFWRLGHNITKHDVDGSIALGYRKFRSFFGTSPSVCAAAYDNLSHVRPIKSCPEHLLWTLLHLKHYATKHISSALVGVSEKKFRKWCHIFIRLLAKMPVIEWENRFHRALRGSNILVSIDGVDFRIMEPSPFNPKWYSHKFHGPGLRYELAICIRTGDIVWAYGGLPCGEWSDLRLARDVFIFGLREGEKAIADRGYKDPNFFDFPNGNNDGKKKQVLARHETLNRRLKQFDCLQQRFRHDLYLHPLYFHSVVNLTQMMIDHGETLYSVDFKISIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTX9</accession>
    <name>E9GTX9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">60S ribosomal protein L27a</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1 5">Belongs to the universal ribosomal protein uL15 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX76935">
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG1742">
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    </dbReference>
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    <dbReference type="OrthoDB" id="1445443at2759"/>
    <dbReference type="PhylomeDB" id="E9GTX9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
    <sequence length="148" mass="16876" checksum="2A05C71D43FEEEE7" modified="2011-04-05" version="1">MSTNRKKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGMHHHRINFDKYHPGYFGKVGMRNFHLRKNQHHMPAINLDKLWTLVSEQTKEKYKDHPEKKVPIIDCVRAGYYKVLGKGILPKQPMIVKAKFFSRIAETKIKSVGGACILTA</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Basu M.K."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="82" mass="8949" checksum="713A9C0AE6B552B5" modified="2011-04-05" version="1">MKVTNTSINKECEEEIDDNVKETEETIGYGRDEDGGKILENAAFTHDNVEANPGGPPVLANSLLNFFVTVTRTKIFSTLVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GV11</accession>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <location>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
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        <recommendedName>
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    <organism evidence="14">
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        <lineage>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="GL732568">
        <property type="protein sequence ID" value="EFX76416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76416"/>
    <dbReference type="EnsemblMetazoa" id="EFX76416">
        <property type="protein sequence ID" value="EFX76416"/>
        <property type="gene ID" value="DAPPUDRAFT_322293"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_322293"/>
    <dbReference type="eggNOG" id="KOG3916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044391_1_4_1"/>
    <dbReference type="InParanoid" id="E9GVH4"/>
    <dbReference type="OMA" id="TEGGHYK"/>
    <dbReference type="OrthoDB" id="1201618at2759"/>
    <dbReference type="PhylomeDB" id="E9GVH4"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033207">
        <property type="term" value="F:beta-1,4-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070085">
        <property type="term" value="P:glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="PTHR19300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glyco_transf_7N" evidence="12">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_transf_7C" evidence="11">
        <location>
            <begin position="142"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX76416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="306" mass="35152" checksum="36DEB51B37C32E0E" modified="2011-04-05" version="1">MCPPVSPLLNGWTDVSNYTRNKASSYSGRSPLQLGGSYQPVECLTNRKLAVVVPYRNRNSQLDIFLRYLHPFLQRQQLDYTIFVVEQTGKLTNPFNRGMLMNIGFTEALRLRSFDCFIFHDVDLLPEDDRNSYACPEVGEPRHLSVAINIFGYRPIGPNHFGGVSSLTTVDFVAVNGFSNRFWGWGGEDDDLFDRLRSKNLTVRRHRPLRQTRYTMLPHDTAKPNPDRKRILQGNRINVSKAIMADGLISLKYRILDLQFESLSTHIFVEIERPPWPPDIVRSRSPELPNSIPRNNIVLNFAASFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9GVK8</accession>
    <name>E9GVK8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_322322</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732568">
        <property type="protein sequence ID" value="EFX76429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76429">
        <property type="protein sequence ID" value="EFX76429"/>
        <property type="gene ID" value="DAPPUDRAFT_322322"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_322322"/>
    <dbReference type="HOGENOM" id="CLU_3089350_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GVK8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX76429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="52" mass="5663" checksum="063F1BC49D43BDE2" modified="2011-04-05" version="1">MVAGRLLPKYLSEWTTEKLNAASVNVLPKANVEGASLEDNKVPLILNNGRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9GW43</accession>
    <name>E9GW43_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 242</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_226107</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM242 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732569">
        <property type="protein sequence ID" value="EFX76330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76330"/>
    <dbReference type="EnsemblMetazoa" id="EFX76330">
        <property type="protein sequence ID" value="EFX76330"/>
        <property type="gene ID" value="DAPPUDRAFT_226107"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_226107"/>
    <dbReference type="eggNOG" id="ENOG502S2GB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115460_1_0_1"/>
    <dbReference type="InParanoid" id="E9GW43"/>
    <dbReference type="OMA" id="GSHRTEM"/>
    <dbReference type="OrthoDB" id="1365284at2759"/>
    <dbReference type="PhylomeDB" id="E9GW43"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009792">
        <property type="entry name" value="TMEM242"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13141">
        <property type="entry name" value="PTHR13141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07096">
        <property type="entry name" value="DUF1358"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX76330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="192" mass="20963" checksum="60D89DD1D4F1B999" modified="2011-04-05" version="1">MLNKDETKNDQMINSVAVSAGAASKEKDERSFKFKAAAFLAGVTGVSILFGFGTTLAAAKKKDPHFFDQGLTGRIEKQTTEPISNQTTAAVRRRVPVSISSVEPGASLAIRALGWGTLYAVTGCSVLFYGIWKLMAVNDLKEFRLKVGTWLPTVPRNNSQGRTEFSGLNDLLQYIIDVDKEKKEASNINDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9GX92</accession>
    <name>E9GX92_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_107488</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732572">
        <property type="protein sequence ID" value="EFX75899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75899"/>
    <dbReference type="EnsemblMetazoa" id="EFX75899">
        <property type="protein sequence ID" value="EFX75899"/>
        <property type="gene ID" value="DAPPUDRAFT_107488"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_107488"/>
    <dbReference type="eggNOG" id="KOG1865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_581742_0_0_1"/>
    <dbReference type="InParanoid" id="E9GX92"/>
    <dbReference type="OrthoDB" id="561804at2759"/>
    <dbReference type="PhylomeDB" id="E9GX92"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="175"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="470" mass="53436" checksum="B975474A59240339" modified="2011-04-05" version="1">MPDFSRNSSLDDKLSLENLCLLHKDKHTEGLFEDILIPCNNRGCRFYSSNHCDSSKKKGKENKLTTHTSVRKRIRLFPAEDEQDKDNKVCVETNSTSTIPVKSFYNKQTKSLSRSPSPSHPTFFFQNLNGSPIPSLVSVDELTGSDSQTSHERPWTRSRPYIFSDPTITYPPYDIGLRNIDNTCYVNATLQALFALPGFTDDLVTAFEGTENLPHFASLLANMITARKKGLPIEVDKINEDLVKNLWMLHPSYSVREQQDASEFLIRLIEHLKLALPAGPINPVESHFECEMIEVVHCTACGKKKKRAQKHTSICLPMPKDSRNLEQCLEDYMAEEERDLACSSCKATTSKISSKFRTLPSKLIMSVNRFSKEAKLAKHIVPPQVLDIRPFLENLESQLPSEYTLAAQIVHIGHSKNSGHYVSHVYCEDGVWRCYDDMSVLTVSIEDEIESVDGEPAYVYFYVHQCRFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9GXD7</accession>
    <name>E9GXD7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_55591</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus</location>
            <location evidence="1 11">Golgi stack membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="GL732572">
        <property type="protein sequence ID" value="EFX75876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75876"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_55591"/>
    <dbReference type="eggNOG" id="KOG2619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032075_3_0_1"/>
    <dbReference type="InParanoid" id="E9GXD7"/>
    <dbReference type="OMA" id="ESAWTAK"/>
    <dbReference type="OrthoDB" id="551308at2759"/>
    <dbReference type="PhylomeDB" id="E9GXD7"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036065">
        <property type="term" value="P:fucosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="PTHR11929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glyco_tran_10_N" evidence="12">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX75876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="315" mass="37472" checksum="F8BA00B4D8763503" modified="2011-04-05" version="1" fragment="single">CPVWQCETSDNRTNVQEYDAVVIHLRTWNKKDLPKLRSPHQRYVFFSMESSAWRAYSVVKSMENLFNWTMTYRWDSDIVYPYGYINPIGNVPLHPSESQMKYFLSHPKVKVNYAQGKTKMATWFVSNCKTVHSSRNKLIELLQRHNIQVDVYGKCGNMTCPKKQDKSFESSDECREMAAQRYKFYFALENSLCRDYVTEKFFENIRRPILPIVFGLHGDHEKLAPPHSFINAANFKNMKALANHMNLLDMNDTLYNEYFWWKPYFQVRDSQKDRNQAMCHLCARLHDEKLPRKIYSNLTDWWEKKSTCIYSPTIS</sequence>
</entry>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_108116"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_108116"/>
    <dbReference type="HOGENOM" id="CLU_1549207_0_0_1"/>
    <dbReference type="InParanoid" id="E9GZ77"/>
    <dbReference type="OrthoDB" id="1114912at2759"/>
    <dbReference type="PhylomeDB" id="E9GZ77"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="173" mass="20071" checksum="26F1138644BB0825" modified="2011-04-05" version="1">MVEEKMVEPRDRDLACQTEAYAEAGHYGATVVYPGFKSSYGTFTYRYDGKSTSQKVRTTNDVEGWHTHLANHAGLRISSRGLNLYILLEVLNEEAVQVDLYTKMLEQGQSLRRQRKTYRELNEKLFKFLDDYNKQHLTSKELLEKCANIYTHFNAIKYAKTANDARVTEIETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
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    <gene>
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    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX74634">
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        <property type="gene ID" value="DAPPUDRAFT_199801"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG4179">
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    <dbReference type="OMA" id="KRTGCFA"/>
    <dbReference type="OrthoDB" id="931915at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050211">
        <property type="term" value="F:procollagen galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
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    </dbReference>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="25"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="623" mass="71813" checksum="362309B054CFB947" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9H1L7</accession>
    <name>E9H1L7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="4">
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX74482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74482">
        <property type="protein sequence ID" value="EFX74482"/>
        <property type="gene ID" value="DAPPUDRAFT_307285"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307285"/>
    <dbReference type="HOGENOM" id="CLU_875119_0_0_1"/>
    <dbReference type="OrthoDB" id="1804065at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237918" evidence="2">
        <location>
            <begin position="19"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX74482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="318" mass="35049" checksum="29CD165AFB265FC6" modified="2011-04-05" version="1">MRLIALSLLAVAVTYVAASTKGQPSKVFDFLNYYGTELESLRQMMTMSLILPARETVTQTTTVVSTVSQSYFIPTRQTVMESTTSTSTITCTKSVAQRCSSVRQRPSSTTRPARPARPTRPTRPVPATNTSTVETVGEEEAVHDSSASTGKKRPEEPEEPELVPSIQEIVGNEEVNDILVEAANDEDEQFPAIAPSAIQRVQSTNMPKPREGRVANPEADPQLLVVYAGNQPQDIESGFLSGSYDPVIAPFSRRYQKPYMAANKRYGDGGQQRQFLQQFFTITRRSTIFEIDIFTVTPTCSEPGRIPQCPSGKKSEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9H210</accession>
    <name>E9H210_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_215182</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="GL732584">
        <property type="protein sequence ID" value="EFX74263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74263"/>
    <dbReference type="EnsemblMetazoa" id="EFX74263">
        <property type="protein sequence ID" value="EFX74263"/>
        <property type="gene ID" value="DAPPUDRAFT_215182"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_215182"/>
    <dbReference type="eggNOG" id="KOG3051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_5_1_1"/>
    <dbReference type="InParanoid" id="E9H210"/>
    <dbReference type="OMA" id="MLYPTDT"/>
    <dbReference type="OrthoDB" id="1027994at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="5">
        <location>
            <begin position="14"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX74263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="226" mass="24135" checksum="44FDCCB4DD0A09EE" modified="2011-04-05" version="1">MINPVILLGPKNSAAILKNAVELLKSGSVIALPTDTLYGIACLSQSPEALKKLYQIKSRDKNKPVAICVSQVSEIAKWGHVTVDERLLHDLLPGPVTLVFERSPALNPELNPGTKLVGIRIPDSWFIRQLSNSCAEPLALTSANISGSQSTLSVEEFLGIWEHLGAVFNGGPIPDGSTARLGSTVVDLSSPGTYRIIRPGCAQTITVEKLEKYGLVEASEPASENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6J5</accession>
    <name>E9H6J5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_326040</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732597">
        <property type="protein sequence ID" value="EFX72673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72673">
        <property type="protein sequence ID" value="EFX72673"/>
        <property type="gene ID" value="DAPPUDRAFT_326040"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326040"/>
    <dbReference type="HOGENOM" id="CLU_1462767_0_0_1"/>
    <dbReference type="OrthoDB" id="1902023at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241742" evidence="2">
        <location>
            <begin position="18"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX72673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="185" mass="19226" checksum="BF02ED123E20A5A7" modified="2011-04-05" version="1">MFKFIVLISLVAGYSTAESVELSVENPTSLSVEDEQNPAEILPEVCSCDGPAPPDLIAAPSGSKIRITLPAGPVSTTTTTSRPVSTTPPPCCRVPGPRGPPGRNGAPGRPGPPGKNGAPGPPGPPGRNDAQPGGIAIPHCPDGYLYNTKTGLCVPSNPIPSNPNGYMNFYKSWSLNKPFKNFYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9H7D8</accession>
    <name>E9H7D8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_110862</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732600">
        <property type="protein sequence ID" value="EFX72358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72358">
        <property type="protein sequence ID" value="EFX72358"/>
        <property type="gene ID" value="DAPPUDRAFT_110862"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_110862"/>
    <dbReference type="HOGENOM" id="CLU_1706054_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX72358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="154" mass="17201" checksum="757A6D44D8E389FC" modified="2011-04-05" version="1">MKTFVCPIERVAARRLLICFVLVHVLTMIECLPLSGTAAVPSALPSSSPLGEDLLRLFNVSNEDVEASRQKQLAIRHSNSVNHHNFPANSRQQQHHHQQHSSSHAAHPEVAVPASAYDAQISIIHQRNRVDYISPLCGWQCLMGLYCGLQLHER</sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>Daphnia</taxon>
        </lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX72309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX72309">
        <property type="protein sequence ID" value="EFX72309"/>
        <property type="gene ID" value="DAPPUDRAFT_201152"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_201152"/>
    <dbReference type="eggNOG" id="KOG1915">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="733" mass="87003" checksum="43212DDCDC601807" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9H8V0</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="164" mass="17838" checksum="A9BBF17E4345C405" modified="2011-04-05" version="1">MELCEHLRPVVRMRVNCSDFILPMETDRMTESSPERSSLSSQGASSSSSSESETVRVNCSDFILPMETDRMTESSPERSSLSSQGASSSSSSESETVRVNCSDFILPMETDRMTESSPERSSLSSQGASSSSSSESETVRCYSASSLSANLQAPSFTFSKYQLQ</sequence>
</entry>
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            <fullName evidence="1">AAA_34 domain-containing protein</fullName>
        </recommendedName>
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    <organism evidence="3">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_326841"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG1513">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048583">
        <property type="term" value="P:regulation of response to stimulus"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026741">
        <property type="entry name" value="SNO"/>
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    <dbReference type="InterPro" id="IPR039187">
        <property type="entry name" value="SNO_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706">
        <property type="entry name" value="PTHR12706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13872">
        <property type="entry name" value="AAA_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="79" mass="8689" checksum="C4CF81DD344226A1" modified="2011-04-05" version="1">MNIQPIEPTKTGLAVLELQNKLPNARIVYVTATGASEPRHLGYMFRLGLWCQGTPFYDFASFIGTIEKNGVGGMELLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9X2</accession>
    <name>E9H9X2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_327131</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732609">
        <property type="protein sequence ID" value="EFX71536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71536"/>
    <dbReference type="EnsemblMetazoa" id="EFX71536">
        <property type="protein sequence ID" value="EFX71536"/>
        <property type="gene ID" value="DAPPUDRAFT_327131"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_327131"/>
    <dbReference type="eggNOG" id="KOG0638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034004_3_1_1"/>
    <dbReference type="InParanoid" id="E9H9X2"/>
    <dbReference type="OMA" id="DPFPVKG"/>
    <dbReference type="OrthoDB" id="1087836at2759"/>
    <dbReference type="PhylomeDB" id="E9H9X2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="8">
        <location>
            <begin position="31"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="8">
        <location>
            <begin position="195"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX71536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="396" mass="44890" checksum="A16A28CE42B8EB86" modified="2011-04-05" version="1">MTVTHLSKEPIRKQTTYTDKGPKPPAGKFLHFDHLTFWVGNAKQAASYYCTRMGFTPAGYQGLETGSRKVAAHLVAQNKIRFVFKSAYEPNDDSEMGPHLVRHGDGVKDIAFSVEDLDAIVQAAKDRGAKVVRDIWQEEDEFGFVRFATVQTYGDTTHTFVERGNYTGFFLPGYNKIPVSEDPLLSTLPTINLNFIDHVVGNQPDLQMESAAEWYTQNLMFHRFWSVDDSQIHTQYSALRSIVVTNYEETIKMPINEPANGLRKSQIQEYTDYYGGAGVQHIALNTSDIITAIRNLRKRGTQFLTVPAAYYDQLRVKLAESPVKIKEDLSVLQELNILVDYDDNGYLLQLFTKPMQDRPTLFLEVIQRNNHQGFGAGNFKALFEAIELDQDARGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9HC90</accession>
    <name>E9HC90_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proliferating cell nuclear antigen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_309373</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732619">
        <property type="protein sequence ID" value="EFX70582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70582"/>
    <dbReference type="EnsemblMetazoa" id="EFX70582">
        <property type="protein sequence ID" value="EFX70582"/>
        <property type="gene ID" value="DAPPUDRAFT_309373"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309373"/>
    <dbReference type="eggNOG" id="KOG1636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_3_0_1"/>
    <dbReference type="InParanoid" id="E9HC90"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="OrthoDB" id="1012066at2759"/>
    <dbReference type="PhylomeDB" id="E9HC90"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PCNA_C" evidence="6">
        <location>
            <begin position="127"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX70582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="261" mass="29052" checksum="2CE383E7074BB431" modified="2011-04-05" version="1">MFEARLLQGSLLKKVMEALKDLLNEAAWDCSDAGIQLQAMDNSHVSLVSLNLRAEGFDKYRCDRNLSMGMNLGSMSKILKCASNEDIITIKAQDNADTVTFVFESPEQDKVSDYEMKLMNLDQEHLGIPETDYACTIRLPSSEFARICRDLSQFGESMVISCTKEGVRFSATGDIGTGNIKLAQSAKVDKEEEAVVIEMQEPVSLTFACRYLNSFTKATSLSKSVQLSMSPEVPLVVEYKIEDIGHVRYYLAPKIEDEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9HD79</accession>
    <name>E9HD79_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="8">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_328199</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="8"/>
    <dbReference type="EMBL" id="GL732622">
        <property type="protein sequence ID" value="EFX70331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70331"/>
    <dbReference type="EnsemblMetazoa" id="EFX70331">
        <property type="protein sequence ID" value="EFX70331"/>
        <property type="gene ID" value="DAPPUDRAFT_328199"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_328199"/>
    <dbReference type="eggNOG" id="KOG0260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000487_3_0_1"/>
    <dbReference type="InParanoid" id="E9HD79"/>
    <dbReference type="OMA" id="RAYYEMP"/>
    <dbReference type="OrthoDB" id="591636at2759"/>
    <dbReference type="PhylomeDB" id="E9HD79"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLA_N" evidence="9">
        <location>
            <begin position="228"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX70331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1457" mass="164254" checksum="21EB95EC700A147B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDB0</accession>
    <name>E9HDB0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_300534</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732623">
        <property type="protein sequence ID" value="EFX70223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70223"/>
    <dbReference type="EnsemblMetazoa" id="EFX70223">
        <property type="protein sequence ID" value="EFX70223"/>
        <property type="gene ID" value="DAPPUDRAFT_300534"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300534"/>
    <dbReference type="eggNOG" id="KOG4234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058463_4_1_1"/>
    <dbReference type="InParanoid" id="E9HDB0"/>
    <dbReference type="OrthoDB" id="1418232at2759"/>
    <dbReference type="PhylomeDB" id="E9HDB0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX70223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="99" mass="11465" checksum="E2F58471442591E3" modified="2011-04-05" version="1">MLYNNRAAAEAKQGKNESALKDCTKALELNPTYFKALMRRAKLYEELDQLDKALADYKELHELEPTNGEVNCALMNLPKRIEEQTEKLKQEMFGKMKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HE27</accession>
    <name>E9HE27_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_113102</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX70028.1"/>
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    </dbReference>
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        <property type="protein sequence ID" value="EFX70028"/>
        <property type="gene ID" value="DAPPUDRAFT_113102"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="283" mass="30949" checksum="900C907E91267B7B" modified="2011-04-05" version="1">MATLGLASQANSARTGMFSPSSLSPGYTHLCYTTARSAGIPRFAILSANHKNVVDLDSGALPVSTSDNMTNLFAMHRALVPTARELQSHEHVEIISPSTKLLSFLILGKLVSSLQLNCLDSMVPIRHNTSFYVAQDLSSSYRFRLTRVICESSDIRHPVIELRQPKEVAGAVASMLIKSLHEREWASGLNDTTTRSFFPTVHSASMLLSAQLNCQLSQILSGHSALNTHQYRFKFRPSPAYSCATLGSASLQHVVNARYPGLPHSKTSLRTGSFGQQWCDTSL</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX68603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68603"/>
    <dbReference type="EnsemblMetazoa" id="EFX68603">
        <property type="protein sequence ID" value="EFX68603"/>
        <property type="gene ID" value="DAPPUDRAFT_62978"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_62978"/>
    <dbReference type="eggNOG" id="KOG4199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039447_1_0_1"/>
    <dbReference type="InParanoid" id="E9HI51"/>
    <dbReference type="OMA" id="QRNGAWA"/>
    <dbReference type="OrthoDB" id="605325at2759"/>
    <dbReference type="PhylomeDB" id="E9HI51"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
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    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
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        <property type="entry name" value="ARMC6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        <location>
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            <end position="407"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="453" mass="50013" checksum="6A013F66B60090E0" modified="2011-04-05" version="1">MVKVITQETFDAVVKENVEEFGLELEEARKDAIQQFTAQGVDLTNIVTDGPGEGGQTHTIVVTLTNLSRQLASEVLKSLEELEKECNIDLAHRIMAEKNGAFPLIVQSLKHYQKNSALRDQCLKTMASLIQGYPDIVTHDGIELLCTVLEEDSSLSTVTLVLNVFCHSCRMHENNRESFMANFKLAARIRKLLESPPTRNQAELIRAVVSDDDVRVEFGRAHDYACMIAEQENGLELLTSLLTEFQTEKTVISELLPTLSRLAVRNEFCQKIVELGGLEFVMDVLAKYYEDKELVESSFFLIKSLAGNDDVKREVSKGNAVPLIAAALGRHKCVASVAEMGCAAIAALCLRTPDNAAAFVANGVGQLVVDILKTHKLKVGVERQASMAIRNIVARRKDLTTVFIEAGVEDLLQTAMKRTQRAPTVEIKAALRDLGCQVQLHEEWTGKGASMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HIS2</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="3">
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68325">
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    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="139"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="181" mass="20408" checksum="926B4FD13AD7CCA5" modified="2011-04-05" version="1" fragment="single">MDNKAFEDVSKNSKLKFRKPESIDHLIQSIKNEENCVVKEKVNNIPIDVISDTQVGKMKNETDASSSYRTGYQGQMEILPTLHELHNPAAESQQQQQEMRVTTAREFVDGSRFKVSTYVPTGIEMENITQGSAQIGNDNSITGLTNRKGSVATVSSHDRNRKMSRDVIPSIEHYRTQPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
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    <organism evidence="2">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732659">
        <property type="protein sequence ID" value="EFX68232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68232">
        <property type="protein sequence ID" value="EFX68232"/>
        <property type="gene ID" value="DAPPUDRAFT_260354"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_260354"/>
    <dbReference type="HOGENOM" id="CLU_1580083_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HJ06"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX68232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="169" mass="19651" checksum="18418C5C6D3EB8EC" modified="2011-04-05" version="1">MDGVAGGKQLFIENETDYPANLERTHLIADEYLDRIIVKLEAFGWISVRDHICDIIGTRNEHREQPVAALASNAAKKKQVVVVDLPNTEIVRKFDEKFHPQLLYAFLTKYVKTSFILKSRDENGTQHAVLTVYGEDEEYHFFHQQKEEAEKSILTNYINRLCVNEHMTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJM3</accession>
    <name>E9HJM3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_114894</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732663">
        <property type="protein sequence ID" value="EFX68063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68063">
        <property type="protein sequence ID" value="EFX68063"/>
        <property type="gene ID" value="DAPPUDRAFT_114894"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_114894"/>
    <dbReference type="HOGENOM" id="CLU_1367461_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="200" mass="22715" checksum="F3F4CBDD0186C1DA" modified="2011-04-05" version="1">MKKGSGYQTEAESWLPGAADFLGEEQEQVFATQGPRANTSKHMSRARSVAEYYDLIDTWMLMQRYEEAIELNKKEMTMFLLSYNTTANALCDEIKRRENVAQATEVHRLQQIIQKARELFLQVQERFTFDGEENFEKAEQGEVEDYFDPGHPAAIEEDLTTDNEDSEEDDGGSDEYNGGAGEDDDCCDWLNGEDCNSTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKB2</accession>
    <name>E9HKB2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcriptional adapter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Transcriptional adapter 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_260990</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TADA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732667">
        <property type="protein sequence ID" value="EFX67854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67854"/>
    <dbReference type="EnsemblMetazoa" id="EFX67854">
        <property type="protein sequence ID" value="EFX67854"/>
        <property type="gene ID" value="DAPPUDRAFT_260990"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_260990"/>
    <dbReference type="eggNOG" id="ENOG502QRMT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071612_0_0_1"/>
    <dbReference type="InParanoid" id="E9HKB2"/>
    <dbReference type="OMA" id="NVHFHND"/>
    <dbReference type="OrthoDB" id="1528613at2759"/>
    <dbReference type="PhylomeDB" id="E9HKB2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="PTHR21277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX67854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="333" mass="37961" checksum="F20B8612ED4C9064" modified="2011-04-05" version="1">MNALDVNEARKRLVDVLGDSSKNYFAHLKSWFCMRTSKEEFDRQARLYLKVDQVHLHNEFLLAIVTKCQSLCQPSTYVYQGVKQKPIVVTEVNKIRPHTIPLQKRNSVEIKPITVTRQVYPKNKPLTVNFDNRFQPVNPVSLLPFSVPCTVEKPQLRYCSQDLTLPDAGLVHGRMLVAAWDAGLDHGCEDKAIKLILAATKQFLRELIIAIITNRKGYRLRENKVIYSVGQPTINPWLHNSWSIQDSTSNSYLTEISQAAEPPHVPAIPQTSQKAERDSAFYLACTTEQVTALQPISVLDVFQTLQVKKGVIPWHTVHAVNMERISQRLYHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLZ6</accession>
    <name>E9HLZ6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_331276</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732683">
        <property type="protein sequence ID" value="EFX67224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67224"/>
    <dbReference type="EnsemblMetazoa" id="EFX67224">
        <property type="protein sequence ID" value="EFX67224"/>
        <property type="gene ID" value="DAPPUDRAFT_331276"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_331276"/>
    <dbReference type="eggNOG" id="KOG0200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_49_4_1"/>
    <dbReference type="InParanoid" id="E9HLZ6"/>
    <dbReference type="OMA" id="YLAMVCA"/>
    <dbReference type="OrthoDB" id="236292at2759"/>
    <dbReference type="PhylomeDB" id="E9HLZ6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
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                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Wolf Y.I."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Andrews J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
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    </reference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Shapiro H."/>
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                <person name="Smith Z."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Yamada T."/>
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                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <source>
            <dbReference type="EMBL" id="EFX65685.1"/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Basu M.K."/>
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                <person name="Casola C."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
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        <text evidence="3">Monomer.</text>
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        <subcellularLocation>
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        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ribosomal large subunit binding"/>
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        <property type="entry name" value="Beta-grasp_dom_sf"/>
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        <property type="entry name" value="G_OBG"/>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Detter J.C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Koonin E.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX64426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="52" mass="5549" checksum="E44A82CAB9A4D024" modified="2011-04-05" version="1">MAMSKAIRLIVNDLPGSCPFSTISLPSKPFIISFAFSKAKCLAFSSPIPLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1548094at2759"/>
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        </location>
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        <location>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX64363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="717" mass="81141" checksum="7134C45984B7C515" modified="2011-04-05" version="1"> </sequence>
</entry>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="222" mass="25734" checksum="9D9288253F5220B2" modified="2011-04-05" version="1">MVCSNYGAGIVLTSTLYKELYSYVRLHPEVVHPNADVCIDAITFHHVKKEEQYRELHMRIGVAIPCFVKHISHCLRLLDALEHQTRRPDEVVVSCSSTTDFTVVSYSYPIRFLITDKKQNASTNHDEMHPQRLELIGKSMGNTDILLRSFFQDREHSQPYSVIDPLDYTIMHNVLRQAPSGCIMLDGIQRIHHGQVSVTKEVYQQVQFPEEPEYEVREYCIE</sequence>
</entry>
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    <name>E9HW45_DAPPU</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3">
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732890">
        <property type="protein sequence ID" value="EFX64037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX64037"/>
        <property type="gene ID" value="DAPPUDRAFT_334656"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_334656"/>
    <dbReference type="HOGENOM" id="CLU_1391528_0_0_1"/>
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        </location>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX64037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="196" mass="23269" checksum="E3C9F0BCBB02EC81" modified="2011-04-05" version="1">MTQVLMSLPPSLKLNFGVAWDSTPAQEKTLRNLTTRLVKMEKNIKQSEEENSYNALMSMKETEKKVGAMGEQALPVRDNKRKRENEEKRKYWECGDESHVRARCRIFKRRLEKEREEDDRDSKRRRYERSPQNRGNHRHHDRNYDSRAAGARDTTTKIRETKTETAENIATQQCLQRMKTKIDQEDGMQIRGRRSI</sequence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9HWP4</accession>
    <name>E9HWP4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb_DNA-bind_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_334930</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX63836.1"/>
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        <property type="gene ID" value="DAPPUDRAFT_334930"/>
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    <dbReference type="eggNOG" id="ENOG502T2J3">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="255634at2759"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Myb_DNA-bind_4"/>
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        <property type="entry name" value="Myb_DNA-bind_4"/>
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            <begin position="15"/>
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        </location>
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        <location>
            <begin position="89"/>
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        </location>
    </feature>
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        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX63836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="207" mass="23738" checksum="840A955585577752" modified="2011-04-05" version="1">MDLLEENLETLCDTKTGKKIILNTIANGLEEAGFANHGSEKGQTCKNKWENLRKEYRTFLSKCQTGSGASATKKKRKFFNEIEKNIGSNNHSYKPPFVSDSLEKTKPSEVSKPNDEITCNNENGEKQDVNQALREKLEKSKKEDKDVSDSPISDTEIYNDSLDEKNSGYSHLNLSVSSFSPQIRLYFTGQYLHLDRWFWLKNIRCLR</sequence>
</entry>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DAPPUDRAFT_119345"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG2968">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005783">
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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            <end position="320"/>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="327" mass="36533" checksum="1277671BD44A6B94" modified="2011-04-05" version="1">MELANEYKLSAWLGQQEDQHKIVLYQCDQSLTPWTQRCIPQADCIMIVALATMEPSFGTIEKQLETIAVRTQKELIILLKEGGDKPRNTVHWLNARSWCSFHHHIQCPPRIFSRKHASRLADGATKPAQLVDRNIHSDFSRLARLLTGESVGLVLGGGGARGAAHVSMIQAIQEAGIPIDMVGGVSIGAFTGALWCIEKDIHEFTRKFSSWSHKMTQLWRQLVDLTYPETSMFSGAGFNTMIRETFGEDSIIEDLWLLYFTITTDITSSCMRLHSYGSVWRFVRASMSLSGYMPPLCVPKDGNLLLDGGYVNNLPGSTCARSTFAFI</sequence>
</entry>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Tsuchiya D."/>
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                <person name="Yamada T."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX62841.1"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="79"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX62841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="177" mass="20218" checksum="CC1F0B46AD6231FE" modified="2011-04-05" version="1">MNEIAIDAPQKVPTIQLTRTGTMNEIAIDAPQKVPTIQLTRTGTMNEIAIDAPQKHQKEETKSRRGTMMSWIAFVAIQRRKDETNNRRGQPCRGDPASNRRNEKSTMTSELDSLCGNPAAKRRNEKYTMNDDELDNFAKVIQQQTDETKGRRLSIISRTALPKQSSNKRTKRRVEDY</sequence>
</entry>
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    <accession>E9I025</accession>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Tang H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61838.1"/>
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        <property type="protein sequence ID" value="EFX61838"/>
        <property type="gene ID" value="DAPPUDRAFT_271678"/>
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            <begin position="1"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61632.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_052726_1_0_1"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX61632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="268" mass="28839" checksum="A451BB0E3A3DF76E" modified="2011-04-05" version="1">MFADGKFLWEALSAIRSTPVSSVLPSPSVLLQGRNFRGNLPFLPSELTPRLVPASTVTSELCRRQAKAVFDTPRRTDARSSVLHVGQRVRTLVGKKWRPGAVQSVCKEPRSYFVRLSDGHVFRRTRWAVNIDKGVANAVDTGLWASVGTNDTTPVPSSGQQPIAPASVTVRHPFQPRNSRAVEVPPACPSPAHAAVPRVNTPAPPTSVSSHISQQEAHQYSGGRRSSSWQDEGPSRAVPVRIFPSARPATTEEQPSGSGPVPTSSCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9I3K0</accession>
    <name>E9I3K0_DAPPU</name>
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        <recommendedName>
            <fullName evidence="4">NADH:ubiquinone reductase (H(+)-translocating)</fullName>
            <ecNumber evidence="4">7.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH dehydrogenase subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_273522</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="4"/>
    <dbReference type="EMBL" id="GL734606">
        <property type="protein sequence ID" value="EFX61428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX61428"/>
    <dbReference type="EnsemblMetazoa" id="EFX61428">
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        <property type="gene ID" value="DAPPUDRAFT_273522"/>
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    <dbReference type="GO" id="GO:0005747">
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:ATP synthesis coupled electron transport"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:electron transport coupled proton transport"/>
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        <property type="entry name" value="ND/Mrp_mem"/>
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        <location>
            <begin position="12"/>
            <end position="34"/>
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        <location>
            <begin position="46"/>
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        <location>
            <begin position="12"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00000766"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Shiga Y."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61051.1"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX61051.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="380" mass="43149" checksum="E2BBC600AD8CEC52" modified="2011-04-05" version="1">MLEKVCLFNEATYTCKLDCLRTCPVLIQLTKLINGHLYCRILLRRSARVDFIGAKIPVFIDLQISFDYYLIYKQLTTRKFFVPVTSDNLVFTNDIVASRSQLTKGSTGRPALHLNLAQITHSRRCYRPPGSSAQSTQNNNKVDRAQVLTSFSGRCPLVKHQQPSSQVIDKSFNDVARNNKSPFKPASPDSLSKRLRKCKTRRERQNVMLADQIEREERNRLEQATIDAAAKAAHDVAIANEVAEFFGDNWIDDCAKLASVRPKTPKKPRKERAVIKTPEPEKPKFNYAARLGMRPDKYLVHSLGKGKIQISAVKMPALITATKIEDKYVLNDKFILYKKLQAMNLRDPETVEKIRQACSSPQKADKSKEDKKAEPENPSN</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="105" mass="11681" checksum="083B6D58568582B6" modified="2011-04-05" version="1">MMVLTNAQYFDSLEVETRDNPTAYLREKRQIAVVPQFVTTNLVQPNILDPASGCFWSGTAPFCIPACGKSYQEMLTDKRGDGKRCWTGYKKRCCPLPAGVSKVLG</sequence>
</entry>
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    <accession>E9I708</accession>
    <name>E9I708_DAPPU</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX60222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX60222"/>
        <property type="gene ID" value="DAPPUDRAFT_278669"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_278669"/>
    <dbReference type="HOGENOM" id="CLU_1519375_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="177" mass="20009" checksum="0BCE30383602BB6D" modified="2011-04-05" version="1">MLPGRREEGKCNSTPPCTLGLCETKVRSVADEDLTIKDFLQLSPELKLPFAVHDSTLQKKEKDSTAINQKNYPVTKQLKLFVLGKSTDAQKGNYVFIKSVAGNRKAVHLYYFNEKSNFTGSAKLLDNGPAAKPGRYVRIDSRYNISFIKEQRTPTGEYWTDETIYYMDAQASRTVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9FQV0</accession>
    <name>E9FQV0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_299891</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90053"/>
    <dbReference type="EnsemblMetazoa" id="EFX90053">
        <property type="protein sequence ID" value="EFX90053"/>
        <property type="gene ID" value="DAPPUDRAFT_299891"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299891"/>
    <dbReference type="eggNOG" id="KOG0885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567747_0_0_1"/>
    <dbReference type="InParanoid" id="E9FQV0"/>
    <dbReference type="OMA" id="MSNSEFW"/>
    <dbReference type="OrthoDB" id="405105at2759"/>
    <dbReference type="PhylomeDB" id="E9FQV0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032008">
        <property type="entry name" value="DUF4792"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032010">
        <property type="entry name" value="DUF4793"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16040">
        <property type="entry name" value="DUF4792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16041">
        <property type="entry name" value="DUF4793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4792" evidence="2">
        <location>
            <begin position="129"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4793" evidence="3">
        <location>
            <begin position="445"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX90053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="557" mass="62898" checksum="05A82EB4467838A4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9FR70</accession>
    <name>E9FR70_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_91808</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP1 inhibitor family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90247"/>
    <dbReference type="EnsemblMetazoa" id="EFX90247">
        <property type="protein sequence ID" value="EFX90247"/>
        <property type="gene ID" value="DAPPUDRAFT_91808"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_91808"/>
    <dbReference type="eggNOG" id="KOG0824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123002_1_0_1"/>
    <dbReference type="InParanoid" id="E9FR70"/>
    <dbReference type="OMA" id="CGVETMN"/>
    <dbReference type="OrthoDB" id="1492626at2759"/>
    <dbReference type="PhylomeDB" id="E9FR70"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042325">
        <property type="term" value="P:regulation of phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008025">
        <property type="entry name" value="CPI-17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036658">
        <property type="entry name" value="CPI-17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16188">
        <property type="entry name" value="PTHR16188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05361">
        <property type="entry name" value="PP1_inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81790">
        <property type="entry name" value="SSF81790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX90247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="139" mass="15796" checksum="C79AE59DF9AECCCA" modified="2011-04-05" version="1">MDNPLSTRVIAAASQSSPNNSDKNSPNRASLHVGFSEEKGEVKEKRERFLTAKYGAHQMALIRKRLAVEMWIYEQLNELHGCTDDSESHDVDLDLDDLLDMEDDDERRSYLQKLLSNAKSTPEAVDTFVSELLNRTKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSK5</accession>
    <name>E9FSK5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_205604</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP30 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89220"/>
    <dbReference type="EnsemblMetazoa" id="EFX89220">
        <property type="protein sequence ID" value="EFX89220"/>
        <property type="gene ID" value="DAPPUDRAFT_205604"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_205604"/>
    <dbReference type="eggNOG" id="ENOG502QWFH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097961_1_0_1"/>
    <dbReference type="InParanoid" id="E9FSK5"/>
    <dbReference type="OMA" id="DEYRICC"/>
    <dbReference type="OrthoDB" id="1520155at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024145">
        <property type="entry name" value="His_deAcase_SAP30/SAP30L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025717">
        <property type="entry name" value="SAP30_zn-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286">
        <property type="entry name" value="PTHR13286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13866">
        <property type="entry name" value="zf-SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="zf-SAP30" evidence="11">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="SAP30_Sin3_bdg" evidence="12">
        <location>
            <begin position="124"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX89220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="185" mass="21838" checksum="95F4498B65565CF3" modified="2011-04-05" version="1" fragment="single">MNGFSTGSGEEDSRDSKRSHDQHCCLIEFDQMIDDGERCPRMAGNASYSKRIQKTVQQRKLRLHMDSSARHIYICDYHKSLIQSVRVRQRKRKDSEDDSNETDRDTLSLQERERDAPEVDLFQLQINTLRRYKRHYKVPTRPGLNKAQLAETLMRHFRTIPVVEKEALHSFLYTVKSNKNKLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUT4</accession>
    <name>E9FUT4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_304783</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88866"/>
    <dbReference type="EnsemblMetazoa" id="EFX88866">
        <property type="protein sequence ID" value="EFX88866"/>
        <property type="gene ID" value="DAPPUDRAFT_304783"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304783"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_11_1"/>
    <dbReference type="InParanoid" id="E9FUT4"/>
    <dbReference type="OMA" id="QWAVWAA"/>
    <dbReference type="OrthoDB" id="533939at2759"/>
    <dbReference type="PhylomeDB" id="E9FUT4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="463"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX88866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="559" mass="62287" checksum="0B7D4F86BF7DF5F4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9FVE6</accession>
    <name>E9FVE6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_310751</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX89118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89118">
        <property type="protein sequence ID" value="EFX89118"/>
        <property type="gene ID" value="DAPPUDRAFT_310751"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_310751"/>
    <dbReference type="HOGENOM" id="CLU_934664_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="298" mass="33910" checksum="7B2BA24194B59ED4" modified="2011-04-05" version="1">MERTTAGQVHVIDPAIADAMNVTLMDPSMVVNSFYDPRQSKTARRFFQKQKLLQQMQNNQLHRHHPHHHHRHSRHSSGHSINNAHSYRSHSSHSPITEEALLNASTSTKAKVSNVNIHVEMGAYDWHELQSRLSDNSWGKSGKQMLPQRKSENGNSRTEVAFADESGINAREELLESQPATNVRSNAKTDKGKRKRHVIYHQRIPKKSKLEDQPVGMAEMGTQVEDDVIREAQEASARRTPSVEKPVYVFVDKEYRERAISHLGSHDEAMKTLPTAKTKKVLDESMDEGAYQKRETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9FVW1</accession>
    <name>E9FVW1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EOG090X0A3R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">EOG090X0A3R</name>
        <name evidence="2" type="ORF">DAPPUDRAFT_304699</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TCO</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX89033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015395">
        <property type="protein sequence ID" value="SVE85014.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89033"/>
    <dbReference type="EnsemblMetazoa" id="EFX89033">
        <property type="protein sequence ID" value="EFX89033"/>
        <property type="gene ID" value="DAPPUDRAFT_304699"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304699"/>
    <dbReference type="eggNOG" id="KOG1637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071313_0_0_1"/>
    <dbReference type="OMA" id="HLKAHHT"/>
    <dbReference type="OrthoDB" id="1202682at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="1">
        <location>
            <begin position="55"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SVE85014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="326" mass="36973" checksum="10DD3DDA335FCFEC" modified="2011-04-05" version="1">MAVTRFQFLSTFSRQFSSISNAHIVQPKLRIEEIRGKRISIFDKEYKRQQSLIPRLEKIEVAYEGFDNETTTLVMNKGVSTPYNCAQHISEHLMKNSVVAEVNGEIWDLHRPIPSDCTLKLLSMKPENQHQASLVNKTFWRSCSYLLGAVVEGSFQDDISVTLHSFPPANVRSGSFVYDVQLSLDDWVPSLNDFRQIAATFQKFVRQNHTFQRLDIDSSVALKMFEDNAFKADQIPHIATKSSSGNTVTVYRCGDHIDISRGPMIASTSLVGRCSIAAVHRLDSRIYRFQGVALPSEIYINHFAFGILETRARKLNPARTPELKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9FX07</accession>
    <name>E9FX07_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Complexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CPLX</name>
        <name evidence="5" type="ORF">DAPPUDRAFT_442634</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complexin/synaphin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX87986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87986"/>
    <dbReference type="EnsemblMetazoa" id="EFX87986">
        <property type="protein sequence ID" value="EFX87986"/>
        <property type="gene ID" value="DAPPUDRAFT_442634"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_442634"/>
    <dbReference type="eggNOG" id="ENOG502S3I2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132159_0_1_1"/>
    <dbReference type="InParanoid" id="E9FX07"/>
    <dbReference type="OMA" id="AKMILGN"/>
    <dbReference type="OrthoDB" id="1626132at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008849">
        <property type="entry name" value="Synaphin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705">
        <property type="entry name" value="PTHR16705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05835">
        <property type="entry name" value="Synaphin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX87986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="142" mass="16506" checksum="AEB370BE74978C2E" modified="2011-04-05" version="1">MAAFVAKQMLGSKMNAVKGLGGNDSEDGDTKDKDDEAERERLEAIKEAEDRRKEKHRKMEVERENMRQDIRDKYNIKKKEEAPEAETLKEPDNPLMRKKKTPEELAKEAEEADQDELTKLKNTLETQVNEWKSQIESKCVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYP9</accession>
    <name>E9FYP9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_312053</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87567"/>
    <dbReference type="EnsemblMetazoa" id="EFX87567">
        <property type="protein sequence ID" value="EFX87567"/>
        <property type="gene ID" value="DAPPUDRAFT_312053"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312053"/>
    <dbReference type="eggNOG" id="KOG0375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_6_0_1"/>
    <dbReference type="InParanoid" id="E9FYP9"/>
    <dbReference type="OMA" id="MESFCCL"/>
    <dbReference type="OrthoDB" id="463522at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005955">
        <property type="term" value="C:calcineurin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
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                <person name="Thomas W.K."/>
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                <person name="Manak J.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="66" mass="7409" checksum="0255657198FB1AB4" modified="2011-04-05" version="1">MSPWYGGNQTATPPPSYSTYATTSSCTDVFKYYTTKAPDLNSTTHAAPSHYTDAPKYYYVLSYYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZD9</accession>
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    </organism>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Dusheyko S."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_235915"/>
    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="63" mass="7251" checksum="FD607C7FE3B3A6BB" modified="2011-04-05" version="1">MCDDDRSYYSPKPSKTFTGITEYGGKMFERSRVFILDGCIRTIYAQLAARTNEQSPVFQLHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1X9</accession>
    <name>E9G1X9_DAPPU</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Tsuchiya D."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX86730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_858588_0_0_1"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="324" mass="36538" checksum="459E6E9E57B7D157" modified="2011-04-05" version="1">MANTENQRKLFAGIVTILRGNHSQLEKVLWFLSKTTGREQIYIELLESAYVSNKEAFQELVERLGEDVDELNRNPPYKRVMDEMWLNHSLPSDGTNFVRGQRLDFQVTLEKRKRFEMLAICLGISILLRLDVLTPESLQKMFPLFNITSPLTNLLNIKELLSISQKLSGDRYEVTASFFYFGCDIFRNWKRHGNSEISGVRCVKNIVDSFTELAPGVAGGFGGELFGSTITPGIGTLVGGVGGGMASTFVCGALFDRLTQWIFNLPKDELLEKAFRDLDLPCNVSNNEINIKFVRLAHQNPPNPPNSDWMKLKGSINTIKKVKV</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="PTHR10218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX86353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="356" mass="40581" checksum="E29A82E7E7C48E5F" modified="2011-04-05" version="1">MGCAVSSTTDKEAVERSKKIDKDLRADGERAAREVKLLLLGAGESGKSTIVKQMKIIHETGYSKEECEQYRPVVYSNTIQSLMAIIRAMGQLRINFADSSRAVDDARLFFTLASAADEGMLTYDLAQVMKRLWMDGGVQHCFSRSREYQLNDSAAYYLNALDRISAPNYVPTQQDVLRTRVKTTGIIETHFSFKGLRFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESMKLFDSICNNKWFVETSIILFLNKKDLFEEKITKSSLTICFPEYPGSNTYEEGAAYIQMKFESLNKRRDQKEIYTHFTCATDTSNIQFVFDAVTDVVIKNNLKDCGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E9G297</accession>
    <name>E9G297_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_92223</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732530">
        <property type="protein sequence ID" value="EFX86206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86206"/>
    <dbReference type="EnsemblMetazoa" id="EFX86206">
        <property type="protein sequence ID" value="EFX86206"/>
        <property type="gene ID" value="DAPPUDRAFT_92223"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_92223"/>
    <dbReference type="eggNOG" id="KOG1690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_2_2_1"/>
    <dbReference type="InParanoid" id="E9G297"/>
    <dbReference type="OMA" id="STAIKWS"/>
    <dbReference type="OrthoDB" id="1294924at2759"/>
    <dbReference type="PhylomeDB" id="E9G297"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="PTHR22811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240797" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="29"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX86206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="215" mass="24985" checksum="C1394961CDFFDFC4" modified="2011-04-05" version="1">MQFLGVSVIFVLYLSCVSGLYFHIAETERKCFIEEIPDETMVIGNYKVQLYDPRTGGFMPSSPGIGMHVEVKDPDDKVVLSRVYSSEGRFTFTSHTPGEHIICLYSNSTKWFSGTQLRVHLDIHVGEQTMDYAGIAQKEKLTELQLRVRQLLAQVDQINKEQNYQRIREERFRQTSESTNQRVLWWSLTQTAILLVMGAWQMRHLKKFFEAKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9G2L7</accession>
    <name>E9G2L7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_237039</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732530">
        <property type="protein sequence ID" value="EFX86294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86294">
        <property type="protein sequence ID" value="EFX86294"/>
        <property type="gene ID" value="DAPPUDRAFT_237039"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_237039"/>
    <dbReference type="HOGENOM" id="CLU_1373481_0_0_1"/>
    <dbReference type="InParanoid" id="E9G2L7"/>
    <dbReference type="OrthoDB" id="266752at2759"/>
    <dbReference type="PhylomeDB" id="E9G2L7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX86294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="234" mass="27364" checksum="D6E5FD0F71BE0142" modified="2011-04-05" version="1">MTMHSALSYYTEAPKYYSVLSYLLHRLHYSVPSCFSKAPADYFTKTVECYIEAVKYYSAPIYTTKTEAAKYYAVPTHYTEAALSCYVEQKYYTDAPVHYTTTYVKPHPPSQLWRRAPIRCCIVDGWIERWFSDVFWYGGYQTATPPPYYTTTTTTYAAISFCTDLFKYYTIKAPDTTTYAVPSHYTDTLKYYSAPSYYTTKAMEYYMTRHAAPSYYTEAPKHYSVLGYLLHRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9G308</accession>
    <name>E9G308_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_236752</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX86413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86413">
        <property type="protein sequence ID" value="EFX86413"/>
        <property type="gene ID" value="DAPPUDRAFT_236752"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_236752"/>
    <dbReference type="HOGENOM" id="CLU_2815003_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9G308"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX86413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="79" mass="9264" checksum="65049837CE85B6F5" modified="2011-04-05" version="1">MFNVLKDLSLNINNYTKSTQQSLNELVYYVLIDLFIPTNWPSKLKSYYPYKFLMDLVTKPEAERLGNHAVDHVQIPEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9G461</accession>
    <name>E9G461_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_313404</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX86067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86067"/>
    <dbReference type="EnsemblMetazoa" id="EFX86067">
        <property type="protein sequence ID" value="EFX86067"/>
        <property type="gene ID" value="DAPPUDRAFT_313404"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_313404"/>
    <dbReference type="eggNOG" id="KOG1366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001634_5_3_1"/>
    <dbReference type="InParanoid" id="E9G461"/>
    <dbReference type="OMA" id="KATIYIH"/>
    <dbReference type="OrthoDB" id="354230at2759"/>
    <dbReference type="PhylomeDB" id="E9G461"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="SSF49410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237140" evidence="5">
        <location>
            <begin position="35"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="domain" description="A2M_N_2" evidence="6">
        <location>
            <begin position="457"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="A2M" evidence="7">
        <location>
            <begin position="664"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="A2M_recep" evidence="8">
        <location>
            <begin position="1277"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1397"/>
            <end position="1417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX86067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1439" mass="159709" checksum="EC460C0390F90253" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9G4B0</accession>
    <name>E9G4B0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_222529</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85584">
        <property type="protein sequence ID" value="EFX85584"/>
        <property type="gene ID" value="DAPPUDRAFT_222529"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_222529"/>
    <dbReference type="HOGENOM" id="CLU_1867126_0_0_1"/>
    <dbReference type="OrthoDB" id="1836235at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236642" evidence="2">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX85584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="148" mass="15456" checksum="6CE4FE7C3E1A7AF1" modified="2011-04-05" version="1">MYRLNTLVILLVSVYAVSARPAESSTTAATTESVDVRQGWNQGQQNANAYPNRQQIGTGYSNPIDTGSYPAGSNSRPSYGYDNAFPDQVNFSAADPHRGVASIFNMNIPLQGGFVGNPIQNQVTGFAPTGYQATGGVSASASAVSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6T4</accession>
    <name>E9G6T4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EOG090X0AQP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EOG090X0AQP</name>
        <name evidence="7" type="ORF">DAPPUDRAFT_194044</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TCO</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX84801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015424">
        <property type="protein sequence ID" value="SVE85043.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84801"/>
    <dbReference type="EnsemblMetazoa" id="EFX84801">
        <property type="protein sequence ID" value="EFX84801"/>
        <property type="gene ID" value="DAPPUDRAFT_194044"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_194044"/>
    <dbReference type="eggNOG" id="KOG0809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038177_3_0_1"/>
    <dbReference type="OMA" id="QTMIIDQ"/>
    <dbReference type="OrthoDB" id="1182451at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028673">
        <property type="entry name" value="STX16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="PTHR19957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="PTHR19957:SF83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="SSF47661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="217"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX84801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SVE85043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="311" mass="35820" checksum="C12A924AD47F94B5" modified="2011-04-05" version="1">MATRSITEIFILMRNNAIQSRNFYSEQSISDTDSLVRHEVDVHGKSHATHVRIPPEWTDSLEEAQYTLTKIQTRLKELSSLQNKHLLKPTFDDSMNEEQQIDAFTQDITKMFTTCHNCIKRIQYNSTSPSLGQAEANLAKNVVTSLVITLQNLSNTFRSDQNAYLNKIKSREERSQQFFGGTSSKDWNYDDWTNTSSQTETPRVMSQQQLMLQEENSSFVEQREKEIQNVVRSIYELNSIFKEISHMVADQGTVLDRIDYNIEHTQAKVHDGLVHLQKADNYQKKNRKMVCIVGLVSTIILLIIILIAVKS</sequence>
</entry>
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    <accession>E9G7S9</accession>
    <name>E9G7S9_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DAPPUDRAFT_238921</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84533">
        <property type="protein sequence ID" value="EFX84533"/>
        <property type="gene ID" value="DAPPUDRAFT_238921"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238921"/>
    <dbReference type="HOGENOM" id="CLU_2887980_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="63" mass="7260" checksum="6A35126B9547F80B" modified="2011-04-05" version="1">MYACDLCQLVRLIKPDFIYPPRTGSNGQNARNPQKDQKPALITPHRTLLEAKREKLKIVYLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7Y8</accession>
    <name>E9G7Y8_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_314926</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84563">
        <property type="protein sequence ID" value="EFX84563"/>
        <property type="gene ID" value="DAPPUDRAFT_314926"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_314926"/>
    <dbReference type="HOGENOM" id="CLU_2111295_0_0_1"/>
    <dbReference type="OrthoDB" id="944088at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="115" mass="13266" checksum="10CC9C1999A38888" modified="2011-04-05" version="1">MQEHIDSIDFEEKKRHNQEMRTTAVKSFFRKTPTKGLGSPKSKDKRATLPESHLAIIELDQFLQTLPQNAAHHAYSFLRMQAKKLDVFDKKLKTHSGFMDLIEMDGQKAPQDKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8Y2</accession>
    <name>E9G8Y2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Tang H."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
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    </feature>
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        </location>
        <ligand>
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        </ligand>
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        </location>
    </feature>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Basu M.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83421">
        <property type="protein sequence ID" value="EFX83421"/>
        <property type="gene ID" value="DAPPUDRAFT_315888"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315888"/>
    <dbReference type="HOGENOM" id="CLU_922163_0_0_1"/>
    <dbReference type="OMA" id="GRQYTPN"/>
    <dbReference type="OrthoDB" id="1927971at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241049" evidence="1">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="302" mass="30275" checksum="1A072ED1B075FDD5" modified="2011-04-05" version="1">MKTHVLLTCLFVILGTSLAENDEEASRKSRHVVPVVMMDDGEVLMDENIDTRTAMMSDDIAIPTVLATRNTEILLDVPTDQKPEEQRFQYGGGSYGRPLGGGYYGRPYGGGYYGGRPGGGYYGRPFGGGFGRQYTPNFGGYSQFGGWSNAGGVSNGQGNGNSGGGTVNYGSGGYGTGYSSGFGRQYTPNFGGYSQFGGLSNAGGVSNGQGNGNSGGGTVNYGGGGYGTGYGSGLIGSGIGGYSSGIGSGYGSGIGSGYGSGIGSGYGSGIGSGYASGIGSGYTTGAGFANGYGIRPNYNFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDG3</accession>
    <name>E9GDG3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_101467</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82078">
        <property type="protein sequence ID" value="EFX82078"/>
        <property type="gene ID" value="DAPPUDRAFT_101467"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_101467"/>
    <dbReference type="HOGENOM" id="CLU_960619_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX82078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="290" mass="31801" checksum="D9A635B12CA3835E" modified="2011-04-05" version="1">MMTSTSSTLRLGLYEVKKLSSDSPSTNNHIGIRERQQGAVTSARSLEVIFNSTAAAEWSLDYKVFLSYSSFKIKNSARLMGFSAGNRPADGHSRDPKMLSSSRSWTGEDRRCHYKIRPWPTGRRLERIAAVPAVPAAAAATTTTTGAASRSPHARTFANGYQMDPGPRRIAAATSRSSLQDRTLAHGSKTGGSPPPPPPEPLQDRRTLGPSPMDIRWDPGPRRIAAATTRSSPLQQRTSKIFKCILVSTSYKLIIIRMFSSFVISSAVAWFVHQWSDSGWFLTTTIGKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GES5</accession>
    <name>E9GES5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_101866</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732541">
        <property type="protein sequence ID" value="EFX82029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82029">
        <property type="protein sequence ID" value="EFX82029"/>
        <property type="gene ID" value="DAPPUDRAFT_101866"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_101866"/>
    <dbReference type="HOGENOM" id="CLU_1397645_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX82029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="195" mass="21987" checksum="9EA2140DF1ED5F1B" modified="2011-04-05" version="1">MSTAREICIKGKRKGDRSQSSEHLRPVNNYPKYYSKAPKYYNTKAPDYYTTIYAAPTCDTEAPAYYLTKAVEHSGSQVRWKSVHLFFEQDEFYCKICNPFKIAAALQSYVDNTSLNLTLLVGKPNFMMAVPSPTTSALLPQVEAEDVYVLPKANVEGVRLEDNKVALTLDDGQKIPNLVVIESMLSFKHDQTSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GF66</accession>
    <name>E9GF66_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_241827</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732541">
        <property type="protein sequence ID" value="EFX81952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81952">
        <property type="protein sequence ID" value="EFX81952"/>
        <property type="gene ID" value="DAPPUDRAFT_241827"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241827"/>
    <dbReference type="HOGENOM" id="CLU_069462_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GF66"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX81952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="344" mass="38539" checksum="7BCBEEFC92E479D4" modified="2011-04-05" version="1">MCDTNPMTEDGDTLKFLQEPDGKGQWMTTQTFVAKNCVTQAIKLAKECHDCPVTSPFGIIANSSNEEFANHNDLTIVWRRPDTTQEPECAYKTIHSSQGNLTRGFSQSKLEDYSAQLELIFNNNKTILCTNDTVLTVMGVPDTYVQLVNPKVRGKRSTNDVPTGIIRLANHTKYCLTYPKLDIYINVNIISCATEDNIETSDESLSTIERGQNFQFLESSLIILTGDTYCIHSWSDNEIAAKSCNGDRNEAAYDTDTWMITDYPGRHDLTPIQIILTDQNLCLSASANETAPGRKMIRNENLLESKAPKESTTTHQGEEIPRLFGITPQFHGTVLSKTKEEYCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9GFR1</accession>
    <name>E9GFR1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Argonaute 3 protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_442510</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the argonaute family.</text>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
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        <location>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="944" mass="105308" checksum="6ABB5874C586D98D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX81520">
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        <property type="gene ID" value="DAPPUDRAFT_50301"/>
    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX81508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX81508"/>
        <property type="gene ID" value="DAPPUDRAFT_317601"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_317601"/>
    <dbReference type="eggNOG" id="ENOG502SQFQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076977_0_0_1"/>
    <dbReference type="OMA" id="RNCIREQ"/>
    <dbReference type="OrthoDB" id="1527387at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX81508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="247" mass="26176" checksum="281C0265384B1D3A" modified="2011-04-05" version="1">MISEIKEFLATNVAAFASSIPPRKQTSGGGGVCGFLTGSVNPGNRNVKGTFWAEQSDAGGCQMPQGDYAVTDAIALGQSQALENLKWRQGLCGQVLRIDCGNGPIDAVVASTCNLNSDSCGVDMIGKTWRRATSNKSPGIVDCSVSLTNRNPLNGNDAICYYRPNSETNNNYYAILGVVNTGGRISSSAVAAGVTGRRNNDGWFEFNGSGSPKFQKNAEVVFRYEDGSSSSFQIGNCRNGGQVQIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9GGY5</accession>
    <name>E9GGY5_DAPPU</name>
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        <recommendedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_102627</name>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732544">
        <property type="protein sequence ID" value="EFX81282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81282"/>
    <dbReference type="EnsemblMetazoa" id="EFX81282">
        <property type="protein sequence ID" value="EFX81282"/>
        <property type="gene ID" value="DAPPUDRAFT_102627"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_102627"/>
    <dbReference type="eggNOG" id="KOG0745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014218_8_0_1"/>
    <dbReference type="InParanoid" id="E9GGY5"/>
    <dbReference type="OMA" id="IESKVAM"/>
    <dbReference type="OrthoDB" id="222603at2759"/>
    <dbReference type="PhylomeDB" id="E9GGY5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="96"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX81282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="375" mass="41685" checksum="8C15F1058F2315C8" modified="2011-04-05" version="1">MWKPLHQPSTRFLKCEKCRHFCKDVDHKKSVKESQEAAAEVKPGQFKKAPPPPKKIYEYLNHHLQWTITTNGFSIICLVFQRWEMKNKNSHELRLDKSNILMLGPTGSGKTLLAQTIAQCLDVPFAICDCTTLTQAGYVGENIESVIAKLLQDANYNVDKAQQGIVFLDEVDKIGAVPGIHQLRDVGGEGVQQGMLKMLEGTIVNVPERNAPRKLRGETIQVDTTNILFVASGAYTGLDRIVSRRKNEKVIILGFGASSSGNSAGRRAATQAGMAEVSSEVDDDESERDAFLRAVEARNLIDFGMIPEFVGRFPVIVPFHSLSQDTLFQMLFGMDKVELTFSPEALRTISKAIEKKTGARGLRAIMETLLLDEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GGZ6</accession>
    <name>E9GGZ6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_242571</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX81114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2963106_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="59" mass="6583" checksum="2E25472A47B83275" modified="2011-04-05" version="1">MAFLEGITIKEARERFNAISSSATRRGHHCPPTPQENPASHANNSQEIISLQEQVKILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GHA4</accession>
    <name>E9GHA4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="2">
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        <name type="common">Water flea</name>
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            <taxon>Branchiopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732544">
        <property type="protein sequence ID" value="EFX81162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81162">
        <property type="protein sequence ID" value="EFX81162"/>
        <property type="gene ID" value="DAPPUDRAFT_317899"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_317899"/>
    <dbReference type="HOGENOM" id="CLU_855950_0_0_1"/>
    <dbReference type="OrthoDB" id="1652730at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX81162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="325" mass="37358" checksum="AF40012042657E73" modified="2011-04-05" version="1">MGRTNVYKQSFEREVLTLLADYDSSGNLEVEILHLQSLNELSLNHQMVHELLIQAASFITDTREKSQVKLLMAFVLENLVTMENVFSQLINLNSGNFAMKVENLEKRLQKCENCVDKPAINLLKRDKRMKVAVEALVAVFEEEADHHAERNANASFLLYFKFHQSTNKNIRYCQWTLKYSIAIQGRSSTIYRFIRERDLLTVPSQNTIQVQERENTKEESVLKLMRWPANICYLGYNQDSNSWGGRFRRVIIDDHPLNKVFEDEELDDEVKEEKVCQGLDVDGGKISEKAAVRHDDHHVPVGGPPVLANSLINFVVKGLTTRFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9GHT1</accession>
    <name>E9GHT1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_22271</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732545">
        <property type="protein sequence ID" value="EFX80893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80893"/>
    <dbReference type="EnsemblMetazoa" id="EFX80893">
        <property type="protein sequence ID" value="EFX80893"/>
        <property type="gene ID" value="DAPPUDRAFT_22271"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_22271"/>
    <dbReference type="eggNOG" id="KOG3761">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_10_0_1"/>
    <dbReference type="InParanoid" id="E9GHT1"/>
    <dbReference type="OMA" id="TGQWIDS"/>
    <dbReference type="OrthoDB" id="799628at2759"/>
    <dbReference type="PhylomeDB" id="E9GHT1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015871">
        <property type="term" value="P:choline transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX80893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="506" mass="54618" checksum="E571A458BCB18F90" modified="2011-04-05" version="1" fragment="single">MAINVGGLVSIIVFYLVILAVGIWAGWRHGKKNQKEATGTESVMLAGRNMGVFVGIMTMTATWVDGGYIMGSAEVVFTSGVAWCQAPFGYAVALFLGGLFFAGPMRSAGYHTMLDPFQEKYGAKIGGILYLPALCGEILWSSAILASLGSTLSVILGLDNTIAVLSSASVAMLYTLFGGLYSVAYTDVVQLFCVAFGLILCVPFAWNNPAVDMENLSPAVWGGTIKTHDIGIYTENYLLLIMGGIPWQVYFQRVLAFRTPKQAQTMSYVAGLGSIILAAPPILLGVVATATDWNVATNGTMNITVAEDGKIILPLVLQYLTPAWVSFIGLGAVSAAAMSSADSSMLSSSSMFARNIYHAIFFPWASERHVVRVIWVAIVVVAALASLVALTVNSIYGLFVLSADLVYVLLFPQLLLVIHWKKYCNSYGSITSMITGFVFRILGGEPLLGLPVVLEYPFYDAELGQLFPFRTLCMIIALLSHVLVSLLAHWIFRNTHLSAKWDVLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIZ1</accession>
    <name>E9GIZ1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_224649</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CPSF6/7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80351"/>
    <dbReference type="EnsemblMetazoa" id="EFX80351">
        <property type="protein sequence ID" value="EFX80351"/>
        <property type="gene ID" value="DAPPUDRAFT_224649"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_224649"/>
    <dbReference type="eggNOG" id="KOG4849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025289_1_0_1"/>
    <dbReference type="InParanoid" id="E9GIZ1"/>
    <dbReference type="OMA" id="QNSHASK"/>
    <dbReference type="OrthoDB" id="1016696at2759"/>
    <dbReference type="PhylomeDB" id="E9GIZ1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110104">
        <property type="term" value="P:mRNA alternative polyadenylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098789">
        <property type="term" value="P:pre-mRNA cleavage required for polyadenylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034771">
        <property type="entry name" value="CPSF6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="PTHR23204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204:SF7">
        <property type="entry name" value="PTHR23204:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="90"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX80351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="421" mass="44389" checksum="0D3FDE451BB765D8" modified="2011-04-05" version="1" fragment="single">MADVPDIDLYADDLGDDFHGDGDEQIGDGVDLYDDVLTSSTSIKQELNGKEKISTLSSHITSSSLHGSSSLIGTPLQLHGSNSSSQSKRIQLYVGNLTWWTTDADVENAISAIGVQDLVEVRFHENRANGQSKGFCVITVGSEISARQCMDKLPKKDLHGQTPIVTFTSKQALNQFEAQSKSRPSRQSSPPRSTGSAPSGVPSLTVGLLGPPPMNGPPPRMMMGPSASSSGPPPLTSLSLPPPPSVRGPPTPGGIPVPPPTHHLLPHPVMSPTVVPRGPPPGMGMRGPPPGMDMNPHRIPPPGNGRPEWANIVQQPAPHVNPAFFPPPVAAPPPGFPPPIGPPPPFITDNRPPHTNEPPNVSEAEFEEVMGRNRTVSSSAIARAVADASTGDYASAIETLVTAISLIKQSKVAHDERCKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKB6</accession>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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            <position position="1"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="151" mass="16685" checksum="B36BA4BE27E2C16A" modified="2011-04-05" version="1" fragment="single">LLEHCHTKSSKALFAGLCAKLANGTKAGDPLCCYIFGEVGRKVIKLLITHNKIYHIKLVVLFLQDLLGEPNGLPITCVGAVWKSFCLMEGGFLEGVNTQPRPIKSLHSLERFTLLQLQLSLAVGATYIGAKFAKIEFLRDYNSKVFFSKTV</sequence>
</entry>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="133" mass="14401" checksum="067C2D821B26FF49" modified="2011-04-05" version="1">MTRCMGALFTISMAGDLNWNGLPREGVANRDSESQKLIHLAGNQRFPKASKFEMEKDSKDFLRHALTRVKQAVARAEKEEAAMAANAAGVEAGARHPLDHSYGNVENPLRSGCSEDTSSVTRARERSAGDPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKU8</accession>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="4">
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732550">
        <property type="protein sequence ID" value="EFX79906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79906"/>
    <dbReference type="EnsemblMetazoa" id="EFX79906">
        <property type="protein sequence ID" value="EFX79906"/>
        <property type="gene ID" value="DAPPUDRAFT_319151"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_319151"/>
    <dbReference type="eggNOG" id="KOG2205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_496328_0_0_1"/>
    <dbReference type="OrthoDB" id="1532732at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044255">
        <property type="term" value="P:cellular lipid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
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        </location>
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    <feature type="chain" id="PRO_5003237534" evidence="2">
        <location>
            <begin position="20"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX79906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="549" mass="60284" checksum="A0C250BBC87B3944" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9GMF3</accession>
    <name>E9GMF3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="6">
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        <name type="common">Water flea</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX79358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79358"/>
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        <property type="protein sequence ID" value="EFX79358"/>
        <property type="gene ID" value="DAPPUDRAFT_319662"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_319662"/>
    <dbReference type="eggNOG" id="KOG2362">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="WIRIGNE"/>
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    <dbReference type="PhylomeDB" id="E9GMF3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:molybdenum ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:pyridoxal phosphate binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="MoCF_Sase_C"/>
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        <property type="entry name" value="MOSC_N"/>
    </dbReference>
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        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="4">
        <location>
            <begin position="178"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX79358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="336" mass="37470" checksum="79954D30A8D9101D" modified="2011-04-05" version="1">MDQIKVVLAVGIGAAFLGAVVYKLYWKSKEEKNFRQLVKGWKACSVVSQLHIFPLKSGLGIPVEEAHAQKIGLVNGELQDRSFMAYNENNNFLFGRIHPTMVLIKISVSGNKVEFTAPNCESITFPIPSQSETEKLVKVRIFGEEVAAFDCGDQVAQWLSQYIFQKDSGARLAHLSYPKVSPRVLKSKPGQNWLKPTDAGLFSNATPFHLLSVESANDLNSRVDGVEISTLNFRPTITVSGCQRPYEEDDWRFVRIGEAVFRYVKGTERCILPTIDPATGIKDPNQEPLRTLRKYRLAEDPVLRKAMGESPLMGISLALEQAGRIRIGDVVYVGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPC8</accession>
    <name>E9GPC8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_245954</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat EBI family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732556">
        <property type="protein sequence ID" value="EFX78703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78703"/>
    <dbReference type="EnsemblMetazoa" id="EFX78703">
        <property type="protein sequence ID" value="EFX78703"/>
        <property type="gene ID" value="DAPPUDRAFT_245954"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_245954"/>
    <dbReference type="eggNOG" id="KOG0273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101984_1_0_1"/>
    <dbReference type="InParanoid" id="E9GPC8"/>
    <dbReference type="OMA" id="DSANCQM"/>
    <dbReference type="OrthoDB" id="1463197at2759"/>
    <dbReference type="PhylomeDB" id="E9GPC8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016575">
        <property type="term" value="P:histone deacetylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="PTHR22846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="118"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="160"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX78703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="221" mass="24500" checksum="DDE1E235AD32713C" modified="2011-04-05" version="1">MDCKITPCDGTLLVTGSYYGYARIWTTDGRLASTLGQHKGPTVALKWNKNGNYILSAGFDKTAIIWDASTSQCTQQFAFHSAPALDVDWQSNVSFASCSTDQYIHVCKLGSDKPTKSFQGHTNEVNAIKWDPQGNLLASCSDDMTLKMWSMKQETCVHDSQAHNKEIYNIKWSPTGLGTKNPNMNLILASASCDSTVRLWDVERGLCIHTLTEYSEVRTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPE9</accession>
    <name>E9GPE9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732556">
        <property type="protein sequence ID" value="EFX78628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78628">
        <property type="protein sequence ID" value="EFX78628"/>
        <property type="gene ID" value="DAPPUDRAFT_245982"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_245982"/>
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    <dbReference type="PhylomeDB" id="E9GPE9"/>
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        </source>
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    </evidence>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="112" mass="12718" checksum="25CAD17B1BD21FB0" modified="2011-04-05" version="1">MVRTINIFDNNRPVQAAVELKNRPGVWLKAKKLSLTPGQAEVKVDLPLPMTCCNLKIEFAAFYENLHASLEMLQCPRCSASVPDHPKVCSNCRENVYQCHKCRSINYDLKDP</sequence>
</entry>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Tsuchiya D."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="66" mass="7851" checksum="EC794EC44600D257" modified="2011-04-05" version="1">MKLRRIDLRACHMQSEHSTTELQPLDMRDYQYVSDTFFLPLDYLHYLGVAEDCTPVFSHAKRALYL</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732566">
        <property type="protein sequence ID" value="EFX76896.1"/>
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    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_248491"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_248491"/>
    <dbReference type="HOGENOM" id="CLU_1066582_0_0_1"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="132"/>
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        </location>
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        <location>
            <begin position="215"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="261" mass="28229" checksum="F593CECF7D643A84" modified="2011-04-05" version="1">MATSESITGMPDLGGQVPGIPDDTGLGGSHHSSRESVRVPLTPEERLIAIERTRIERDTLAAVLEEQCDELANYVINRGSSHQTDDTSGSGSSSSYFGNNYLQYHHVQHPSVQHHHHPGYYPAASSSFHHEQNLSAADGGGGYQGASISSPSPSPNGNSNKNGSYARFGHHPSAYHHYHGSVAVPLAHYANSLNHPHQGGPAHHLTAGRFSVHHSPFAHHHRPPPPPGTRRAGGCPSRRHPVRPRSLLLWRRSTPPKINSN</sequence>
</entry>
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    <accession>E9GW88</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="8">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="10">
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        <lineage>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family. Furin subfamily.</text>
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        <property type="protein sequence ID" value="EFX76306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76306"/>
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        <property type="protein sequence ID" value="EFX76306"/>
        <property type="gene ID" value="DAPPUDRAFT_306271"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306271"/>
    <dbReference type="eggNOG" id="KOG3525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002976_4_0_1"/>
    <dbReference type="InParanoid" id="E9GW88"/>
    <dbReference type="OMA" id="MANITGK"/>
    <dbReference type="OrthoDB" id="473018at2759"/>
    <dbReference type="PhylomeDB" id="E9GW88"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030173">
        <property type="term" value="C:integral component of Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="SSF57184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="P/Homo B" evidence="8">
        <location>
            <begin position="324"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="653"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX76306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="681" mass="74127" checksum="19F1267F5E324821" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GWE3</accession>
    <name>E9GWE3_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_249314</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732570">
        <property type="protein sequence ID" value="EFX76202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76202">
        <property type="protein sequence ID" value="EFX76202"/>
        <property type="gene ID" value="DAPPUDRAFT_249314"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_249314"/>
    <dbReference type="HOGENOM" id="CLU_2560610_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="82" mass="9474" checksum="9F64D3A051A7AAB3" modified="2011-04-05" version="1">MSNLDLLFVSGPRPRSRKKNPDCDFRSKFEPIPSQWNSVTGRSRILGETFAPTGTDFREKKIHLFFRALKKALVKTPLVRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9H062</accession>
    <name>E9H062_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_306939</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732579">
        <property type="protein sequence ID" value="EFX74936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74936">
        <property type="protein sequence ID" value="EFX74936"/>
        <property type="gene ID" value="DAPPUDRAFT_306939"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306939"/>
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    <dbReference type="OrthoDB" id="1894630at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="185" mass="20694" checksum="C0E73594CD6DBC5C" modified="2011-04-05" version="1">MFLDIHGGCSPPPPPCISVAAVGSKPFFVIFARIVVVSFFRPSSSIFNRHFLFIFLCLNTGEGDSVFICFPSFGTSSIYIYIQIPHQTRHKSIKNYIIVWVRVVAVERTPVIGIIIQSVFFSAFCTIYNRFSSRSAGGFLTLPSHFPAIMLCTPIDCTSSVLVTQQQNTRKKKKITINFTPSRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9H104</accession>
    <name>E9H104_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_251731</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732582">
        <property type="protein sequence ID" value="EFX74547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74547">
        <property type="protein sequence ID" value="EFX74547"/>
        <property type="gene ID" value="DAPPUDRAFT_251731"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_251731"/>
    <dbReference type="HOGENOM" id="CLU_593495_0_0_1"/>
    <dbReference type="InParanoid" id="E9H104"/>
    <dbReference type="OrthoDB" id="1852819at2759"/>
    <dbReference type="PhylomeDB" id="E9H104"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX74547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="461" mass="52770" checksum="C9B2E5CEEC7AD529" modified="2011-04-05" version="1">MDLTRLMGGHPITSNRLPFEEKIFFFDRRSKEYLNHQGSKLLHHNVCCSSSYTTKALEYYTEAPTETTQLRMLPKPTTSRLQLITSPKLSNSTLERPSTTEISQVSFSDTQHGNPEVSNKLRFRQWNGQRVKVLNENLFQSLSGVLKDAHEHVALFRNIDGGNIGRVLRSPKYLSQWTTEKAGDVTFFCDIKLGRCCMEHDHHAVGSGRLAGENNTGKETWMKNCSALLPSAFFIVLSVRNRAHNYYTTKAPEYYTEADAAPSYNIKRATPKLPSTKTSKSPEYYTYVAPACCTEAPKYYLPPTYYTTKAAEYYTEPPKYYTNKAPEYYTTTCASLSLYTEAPKYYSALSYTTTTEADKYYAAPTYYTAAAPSYYASVYYTTTYATPSYYTEAPMYYTTKAPEYYNTTYAAPPNYTEASKYYSIPSYYTTPYASPTYYRDAPKYYNYVQICRSYDLNSVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9H1M7</accession>
    <name>E9H1M7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FGGY_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_307292</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732583">
        <property type="protein sequence ID" value="EFX74473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74473"/>
    <dbReference type="EnsemblMetazoa" id="EFX74473">
        <property type="protein sequence ID" value="EFX74473"/>
        <property type="gene ID" value="DAPPUDRAFT_307292"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307292"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021676_1_1_1"/>
    <dbReference type="InParanoid" id="E9H1M7"/>
    <dbReference type="OMA" id="SCSRETQ"/>
    <dbReference type="OrthoDB" id="1027013at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050277">
        <property type="term" value="F:sedoheptulokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07777">
        <property type="entry name" value="FGGY_SHK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042027">
        <property type="entry name" value="SHK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="465" mass="50535" checksum="39FEF4CD823B38F1" modified="2011-04-05" version="1">MATAANLVLGLDLGTTSVKVSVVDIHSRKVVAKQSKDTQAGEGAEQDVSKIISAVHNCIGRIPRDLLKNVTKIGVCGQMHGVVLWNKETAWTTSSSDRFELGKGPLSSLYTWQDSRCSLEFLSDVPKPDSHLRIASGYGCATLLWKLRNEPEELSLYSCAGTIQDFLVSMLCDLDCPVMSIQNAASWGYFNTQDKTWNLDILKTVDFPIHLLPKVMDSGSVAGTLSKTWCGIPRGTQVLTALGDMQCSVLSTLANEIACTAVLNISTSAQLSFRMPADFTLPDTQSSIEYFPYFDNRYLAVAASLNGGNVMASFVRMLQSWMQDLGFGVPQSLIWDKMLTLVKQSNSTEQAMTIIPTLFGERHLSRLPAAEVSNINSGNISLGNVAKALFEGLITNLHNMMSTTLLEQYGVTQLVGTGSALSRNQPLQQQVAVQYKNIPFKTVQEGDASYGAALAALNTPRTPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9H1R1</accession>
    <name>E9H1R1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_307326</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732584">
        <property type="protein sequence ID" value="EFX74217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74217">
        <property type="protein sequence ID" value="EFX74217"/>
        <property type="gene ID" value="DAPPUDRAFT_307326"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307326"/>
    <dbReference type="HOGENOM" id="CLU_2308837_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="100" mass="11308" checksum="7ECFD948227B3721" modified="2011-04-05" version="1">MEAFTGMVGDPIVHVSDTRDPSRIQRAKTNKETKEKRKGNVCNAQLAGAQAERMESRERERGRTKNRSHYICYFVALCSYILPAGRASQLLRNCYVLGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9H239</accession>
    <name>E9H239_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="2">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_57431</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="GL732585">
        <property type="protein sequence ID" value="EFX74204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74204"/>
    <dbReference type="EnsemblMetazoa" id="EFX74204">
        <property type="protein sequence ID" value="EFX74204"/>
        <property type="gene ID" value="DAPPUDRAFT_57431"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_57431"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_3_2_1"/>
    <dbReference type="InParanoid" id="E9H239"/>
    <dbReference type="OMA" id="DLAWQMF"/>
    <dbReference type="OrthoDB" id="693882at2759"/>
    <dbReference type="PhylomeDB" id="E9H239"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="SSF48225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX74204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="474" mass="54233" checksum="EA0DCFBFAD0607E5" modified="2011-04-05" version="1">MLFISLDSQMMKHAWDGYVKYAWGYHELRPISRHGHSSSLFGDFSNTGVTIVDSLDTLYIMGLMDEFQRARDWIEHNLDFKKLTWGEVSVFEINIRFVGGLLSCFALTGDRMFREKALLIAERLLPAFDTPTGIPLGIVNMENGVSRNPSWASEGSSILSELGTLSLEFNYLSDVTGKDVFRQKIQKLTGTIKRLDRHADGGLYPNFINPWTGDWGDRHVSMGAFGDSFYEYLLKSWLLSGRQDDEARLMYIDAVEAAMSKLIQVSREGFTYFADSNSGRLEHKMQHLACFSGGMLGLGGFYLGEPFKRRHMAMGKAITRTCRESYNRSTSQLGPETFRFNEQLEAEGLEPEAAYLLRPEVVESYFIMWRLTHDPIYREWGWDVVLALERHCRVEGAGYSGLKNVNEEKPVKDDVQQSFFLAETLKYLYLLFSDDDVLPLDQWVFNTEAHPLPVSLPIKDISTPNPKFVFRDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2L1</accession>
    <name>E9H2L1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_252394</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732586">
        <property type="protein sequence ID" value="EFX73993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX73993"/>
    <dbReference type="EnsemblMetazoa" id="EFX73993">
        <property type="protein sequence ID" value="EFX73993"/>
        <property type="gene ID" value="DAPPUDRAFT_252394"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_252394"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2029029_0_0_1"/>
    <dbReference type="InParanoid" id="E9H2L1"/>
    <dbReference type="OrthoDB" id="999269at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX73993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="122" mass="13485" checksum="329F1F0B07C9408D" modified="2011-04-05" version="1">MSSDKKFAYCCNKGKDILPDRKECPKFLKSILTNSYPQAANFTKKIGNYNSANDFATMGANISLPPGWGPHCFRIHGMVDHRTSSFGQNSQNPGNSDLYFMDSAQAKTFNCTTRQMQAASDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2U0</accession>
    <name>E9H2U0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_324827</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732587">
        <property type="protein sequence ID" value="EFX73840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX73840"/>
    <dbReference type="EnsemblMetazoa" id="EFX73840">
        <property type="protein sequence ID" value="EFX73840"/>
        <property type="gene ID" value="DAPPUDRAFT_324827"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_324827"/>
    <dbReference type="eggNOG" id="KOG4012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_680203_0_0_1"/>
    <dbReference type="InParanoid" id="E9H2U0"/>
    <dbReference type="OrthoDB" id="1565299at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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                <person name="Arnold G.J."/>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="247" mass="27663" checksum="095119605CABA9E2" modified="2011-04-05" version="1">MMVAIIMTTLRSSIPSKEPYFDAVGTQSELNGDEFPYGLSRNKVTSIYPAVLPLVNQHRYMPENNQRILINLASYTKHFKVKTITFVSVTSLTTIQTQKCIPEIEFAYGSTSVTCGRKRRAIVRSLDDKSEGIQSAIHPSDVQPMEPTDLSTLELRTRENRQIVSSKEEDALDEEQWSSVTPQSNHFRQKRFFVHFVATTTSISSTLFSTTTTKTVYLLGTIANRQLVCLPDGYAVCSSSYSSPTPS</sequence>
</entry>
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                <person name="Thomas W.K."/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="HOGENOM" id="CLU_521007_0_0_1"/>
    <dbReference type="OrthoDB" id="1868815at2759"/>
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            <end position="45"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="150"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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</entry>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <sequence length="351" mass="38024" checksum="43060A6296CC1CBF" modified="2011-04-05" version="1">MKTSVAAILLLACAVSGRWVQQPTTSDVARQFQSQDGFGQAKFGYSHPGQSAETHRDAKGNQVGSYAYISPEGREIRVNYIADENGYRVDNDHTQETAEVAAARSAHLAAHAAALAAARAATPDQEQWDAPQPIKSKPVVTVPQQQSWSAPQQTTWEAPQRSWAAAEPVQVNHGLPQPVEDTPEVKAAKAEFYASYREAAARAPQEENVIAPQQTNWDAPQQKSWTAPQQNTWSAPQQSNWVAPQSVQPSTSDTARQYQSQDGFGQAKFGYSHPGQSAETHRDAQGNQVGSYAYINPEGKEIRVNYIADKNGFRVDNDHTQETAEVAAARSSHMAAHAAALAAAKAASPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9M5</accession>
    <name>E9H9M5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein DpuGr13</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="6">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
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        <location>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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    <sequence length="373" mass="42768" checksum="12252984E369F02E" modified="2011-04-05" version="1">MSFQWSLQPMIKWMHFIGVYLESPGKDNSSRFRLFVTAYGFILFFVNVYSNGMMAAKFLQGFENISHQTTSSVLWNAVVSQTNYILMTIGCQLSLISGAVSTWPGLIHILREMEKERYFVSKDFHHFRRIYLSGLGFLIAVILAILGIAVTIIMSTQNQTKVDTLFQICFTFLLIFVFSGGALFSCFGWMVASMLTILAERVVEQSNSNCSGCDWEKTFVRWRHLYLKISRLVDKMNECYGFLLLFLITSSFVVTINSSFIIMRDVNDEGIDYNCFIHSFFLIIQFSHFAVLAYVPHRIRESAIYLSKQLRELKIGNEARQNKVNFFILDVLNSLPQITALGLFDVNLRLAPTIVGTTLTYLVILCQLHYSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9N4</accession>
    <name>E9H9N4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_111718</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732609">
        <property type="protein sequence ID" value="EFX71516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71516"/>
    <dbReference type="EnsemblMetazoa" id="EFX71516">
        <property type="protein sequence ID" value="EFX71516"/>
        <property type="gene ID" value="DAPPUDRAFT_111718"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_111718"/>
    <dbReference type="eggNOG" id="KOG3399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043857_3_2_1"/>
    <dbReference type="InParanoid" id="E9H9N4"/>
    <dbReference type="OMA" id="GQHGKAF"/>
    <dbReference type="OrthoDB" id="1431042at2759"/>
    <dbReference type="PhylomeDB" id="E9H9N4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PTHR13848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="15"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX71516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="116" mass="13163" checksum="E89BEFF341176433" modified="2011-04-05" version="1">MVKTFQAYLPECCHRTYSCVHCRAHLANHDELISKSFQGSQGRAYLFNSVVNVGCGPAEERVLLTGLHAVADIYCESCKTTLGWKYEHAFESSQKYKEGKFIIELAHMIKDNGWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9Y0</accession>
    <name>E9H9Y0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_255690</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732609">
        <property type="protein sequence ID" value="EFX71481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71481">
        <property type="protein sequence ID" value="EFX71481"/>
        <property type="gene ID" value="DAPPUDRAFT_255690"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_255690"/>
    <dbReference type="HOGENOM" id="CLU_790527_0_0_1"/>
    <dbReference type="InParanoid" id="E9H9Y0"/>
    <dbReference type="OrthoDB" id="1824648at2759"/>
    <dbReference type="PhylomeDB" id="E9H9Y0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="312" mass="34717" checksum="1875E4C8D5F0B3D6" modified="2011-04-05" version="1">MEDLFIHRRNSNVNLDKTHPRQRQPAEGRGQFACPSLSKVTEIITQNCQCCGVEVGPIPSNVNLLEERPLCHSTEVNYGDVLLSGVGSLMAGAITGVPMSPADDNEPQQRKNTTPRRLLLTKQNNVNTYLLYEVLQLSIGHAAVRCCIVMAKATTGVPISSGYGGCQTATPPPYYKTKSTYATSTYYNEAPKYYTTKLSDPAYYTDALKYYSAPTEYYTTKGAEYYTTKGAEYYTTKGAEYYTTKGAEYYTTKGAEYYTTKGAEYYTTKGAEYYTTKGAEYYTTKGAEYYTTKGAVYDTTAAANSYYVEPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9HA61</accession>
    <name>E9HA61_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PIP49_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_327242</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIPK family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732610">
        <property type="protein sequence ID" value="EFX71406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71406"/>
    <dbReference type="EnsemblMetazoa" id="EFX71406">
        <property type="protein sequence ID" value="EFX71406"/>
        <property type="gene ID" value="DAPPUDRAFT_327242"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_327242"/>
    <dbReference type="eggNOG" id="ENOG502QUEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052524_0_0_1"/>
    <dbReference type="InParanoid" id="E9HA61"/>
    <dbReference type="OMA" id="TKICRRA"/>
    <dbReference type="OrthoDB" id="1199714at2759"/>
    <dbReference type="PhylomeDB" id="E9HA61"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020519">
        <property type="entry name" value="DIPK2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022049">
        <property type="entry name" value="FAM69_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32073">
        <property type="entry name" value="PTHR32073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12260">
        <property type="entry name" value="PIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PIP49_C" evidence="5">
        <location>
            <begin position="215"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX71406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="435" mass="49193" checksum="CC3ABA9704218D3D" modified="2011-04-05" version="1">MTPLLVWIVTLGVFSTALLRSAIPIYLNVADEKFLELKKCPACYGVMLCPAFLMGDIVPETWSRFKAAQLLNTKNVYFATFKDKHVVMKKLGHDPQLEQLDHHILQQSVGLLNNPIQQVSVSAAVRPYTQQNVWLDCVKDLEGNGSTLVHRLRVFDPSSQDIISNDLQRSVGSFRGSDMLMCPSQRKLNYIENEFVKNNFGLYRLTCLYNLMTLLLLNSEPLIFQTFPAKEGWPFPIYYGACGRVVVEEYVGPNLAQWLPQASWKERINAALQLLIIADKFTNGAADFRLYLTDLSLFNTAVGSDGTLKIVDGENIVMVDLEKIRKDRPENFDVPYASDNAGCEHLPFDPHCMSYSEQDMCNRLHNDHNFFAVCRELFSPLDSFGLANGLPEKILKRFPLIPVYQTDCYSSTIPGVRKSAAKNLISIYKEILADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E9HBA6</accession>
    <name>E9HBA6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_327633</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the exportin family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX70984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70984"/>
    <dbReference type="EnsemblMetazoa" id="EFX70984">
        <property type="protein sequence ID" value="EFX70984"/>
        <property type="gene ID" value="DAPPUDRAFT_327633"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_327633"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011906_0_0_1"/>
    <dbReference type="InParanoid" id="E9HBA6"/>
    <dbReference type="OMA" id="TSETICK"/>
    <dbReference type="OrthoDB" id="132850at2759"/>
    <dbReference type="PhylomeDB" id="E9HBA6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
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    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="PTHR11223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="41"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX70984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1075" mass="122891" checksum="B2A991636098594E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HBI9</accession>
    <name>E9HBI9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_112279</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_112279"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_112279"/>
    <dbReference type="HOGENOM" id="CLU_2006199_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="124" mass="14297" checksum="9859B38656FA18CA" modified="2011-04-05" version="1">MASLDSQFIWSLELDNQLMELIEQFPCLYNRNDESFKLPRKRNDAIAEKGRILKCDIPKETENTKRTAVEEDHPSKKIIITTENTVWSSYGISLGQTLSNLNHKAACSLRHSIETIIFTELKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9HC24</accession>
    <name>E9HC24_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ENGC_GTPASE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_17433</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732618">
        <property type="protein sequence ID" value="EFX70734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70734">
        <property type="protein sequence ID" value="EFX70734"/>
        <property type="gene ID" value="DAPPUDRAFT_17433"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_17433"/>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732625">
        <property type="protein sequence ID" value="EFX70078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70078">
        <property type="protein sequence ID" value="EFX70078"/>
        <property type="gene ID" value="DAPPUDRAFT_257540"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_257540"/>
    <dbReference type="HOGENOM" id="CLU_2851939_0_0_1"/>
    <dbReference type="InParanoid" id="E9HDT0"/>
    <dbReference type="OrthoDB" id="1548094at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="65" mass="6933" checksum="6E374DDB71E4C53A" modified="2011-04-05" version="1">MVCSNRSLSHVVKFDGSNLPLWKLGLDVALEEHDVQSATDGTCLMPPELITSLSGPAPPTLTQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>E9HFD3</accession>
    <name>E9HFD3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_300912</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX69553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69553"/>
    <dbReference type="EnsemblMetazoa" id="EFX69553">
        <property type="protein sequence ID" value="EFX69553"/>
        <property type="gene ID" value="DAPPUDRAFT_300912"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300912"/>
    <dbReference type="eggNOG" id="KOG0904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9HFD3"/>
    <dbReference type="OMA" id="EHANWTV"/>
    <dbReference type="OrthoDB" id="204282at2759"/>
    <dbReference type="PhylomeDB" id="E9HFD3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052742">
        <property type="term" value="F:phosphatidylinositol kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014065">
        <property type="term" value="P:phosphatidylinositol 3-kinase signaling"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0036092">
        <property type="term" value="P:phosphatidylinositol-3-phosphate biosynthetic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
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        <property type="entry name" value="PI3/4_kinase_CS"/>
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        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003113">
        <property type="entry name" value="PI3K_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
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        <property type="entry name" value="PI3K_Ras-bd_dom"/>
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    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PTHR10048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02192">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00794">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PI3K_ABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51546">
        <property type="entry name" value="PI3K_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K-ABD" evidence="8">
        <location>
            <begin position="14"/>
            <end position="103"/>
        </location>
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    <feature type="domain" description="PI3K-RBD" evidence="10">
        <location>
            <begin position="185"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="11">
        <location>
            <begin position="324"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="678"/>
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    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="7">
        <location>
            <begin position="780"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-loop" evidence="5">
        <location>
            <begin position="786"/>
            <end position="792"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00269"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00879"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50290"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51544"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
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    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX69553.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1048" mass="119769" checksum="FF592F11D074DCBA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HG03</accession>
    <name>E9HG03_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_113758</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732638">
        <property type="protein sequence ID" value="EFX69343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69343">
        <property type="protein sequence ID" value="EFX69343"/>
        <property type="gene ID" value="DAPPUDRAFT_113758"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_113758"/>
    <dbReference type="HOGENOM" id="CLU_1519376_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HG03"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX69343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="177" mass="19828" checksum="F0E9ECF612389C91" modified="2011-04-05" version="1">MDEDYQAEAINLDELHEEYPSVNKDVSKIKMQIENSLTLIELEGSANEVDGAEVIYSKMDGDQARAVPEGRNEDGLQMKKGSEAIYPKMDGDQARAVPEEGNEDVYLKVKFSWDENAKSKRKKSFLLIKNSKRPKKEDKAQNIDGEAELCDVFSDFCNNDDSRGSLIVGQPDKSCAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9HG16</accession>
    <name>E9HG16_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cilia- and flagella-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Coiled-coil domain-containing protein 104</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_113771</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFAP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732638">
        <property type="protein sequence ID" value="EFX69338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69338"/>
    <dbReference type="EnsemblMetazoa" id="EFX69338">
        <property type="protein sequence ID" value="EFX69338"/>
        <property type="gene ID" value="DAPPUDRAFT_113771"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_113771"/>
    <dbReference type="eggNOG" id="KOG4511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050059_0_0_1"/>
    <dbReference type="InParanoid" id="E9HG16"/>
    <dbReference type="OMA" id="LVDFMLG"/>
    <dbReference type="OrthoDB" id="1373952at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023379">
        <property type="entry name" value="BART_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042541">
        <property type="entry name" value="BART_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038888">
        <property type="entry name" value="CFAP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21532">
        <property type="entry name" value="PTHR21532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11527">
        <property type="entry name" value="ARL2_Bind_BART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARL2_Bind_BART" evidence="9">
        <location>
            <begin position="51"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX69338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="389" mass="44000" checksum="27D86F5491D1C11C" modified="2011-04-05" version="1">MDRALGQELNSPVFRRRVSIVDAICQFQNRPKLPPSAMEQAKSETDNENNADWILDSLVAYLRGPIWNTPILNFIEQKSVGDGEQYESEYLGIHKDFRNLVDVMLGAYMDDLSLQPEHLESALSQIQPSVRSAALQQLLEPVQSAGDYDRFKVLMRSKNEQLHNEAVEMLRQKRNHPADGPAIENRSSVDEFSEEDINEAIRQSLAEHVAERNAQVQEKREVDRALAASVAGLLKTNLSVEDEESVTTLPEASEPPPANQVESPAKGLFILKELLVFKKFKSLLDLDLVAMRIPDPAEVEQRRVQLRAQRDKILSQKRKERELQLEQQERTDRVAGESSKPGMSRPRSGRAARAALAGEASPEVDERTIQYRRLLLQKIKEEVEGVPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9HHD2</accession>
    <name>E9HHD2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_114202</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL732647">
        <property type="protein sequence ID" value="EFX68839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68839">
        <property type="protein sequence ID" value="EFX68839"/>
        <property type="gene ID" value="DAPPUDRAFT_114202"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_114202"/>
    <dbReference type="HOGENOM" id="CLU_141217_0_0_1"/>
    <dbReference type="InParanoid" id="E9HHD2"/>
    <dbReference type="PhylomeDB" id="E9HHD2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241148" description="Kinesin motor domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="PTHR13954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="263" mass="30392" checksum="343A61A165736C0D" modified="2011-04-05" version="1">MKWVYFGLSKQVNPRGSHSISGMRGTQNWHSPEILKIFIFEEEENGGKTTSPDIRPRGTVKSDVFSAGLVFGYYLLGGHHPFGSAINVPPNIFKNEPVNLPKIKEHPMHAIIMEMLNDNPDERISSADVVLRIKFFTIQNRVKEYKKKMRQEINAFFKNSKVTDWKESEKNKKFEEMFKRYLDEAKKEFPTTDVMFQYGMKLTVHLMKKVQDQWEKENSVPAKLESNKEILRKNFMKVSNGVAQTGLFASNMADIGRTNYSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJI7</accession>
    <name>E9HJI7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_330421</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-K/MCM22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732662">
        <property type="protein sequence ID" value="EFX68125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68125">
        <property type="protein sequence ID" value="EFX68125"/>
        <property type="gene ID" value="DAPPUDRAFT_330421"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330421"/>
    <dbReference type="HOGENOM" id="CLU_1662556_0_0_1"/>
    <dbReference type="InParanoid" id="E9HJI7"/>
    <dbReference type="OrthoDB" id="1369102at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020993">
        <property type="entry name" value="Centromere_CenpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401">
        <property type="entry name" value="PTHR14401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11802">
        <property type="entry name" value="CENP-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX68125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="159" mass="18312" checksum="B691E70CE39026E2" modified="2011-04-05" version="1">MAAYKAVAENEHGTTGLQSDAHPLCHCDIVIYNPMVYLKEKRSLGNKEEELEEERLSELKEKLENAKRQRGEMKNNLKKTIQKYFPESEIPGFTGVYSLLKNLTKRLLDGERDAYVEVQNTWPYYLATLEANGIIEYHPTDRSKVRVVDFSDGRLGQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9HMT3</accession>
    <name>E9HMT3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_Tnp_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_331560</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732690">
        <property type="protein sequence ID" value="EFX66950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66950">
        <property type="protein sequence ID" value="EFX66950"/>
        <property type="gene ID" value="DAPPUDRAFT_331560"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_331560"/>
    <dbReference type="HOGENOM" id="CLU_1604386_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HMT3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Tnp_4" evidence="2">
        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX66950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="166" mass="19526" checksum="784C6AFC5F6DAF5A" modified="2011-04-05" version="1">MKKLKTEHKRAAAIRFLRKQTKPWSTSQDLDVEMEWEEERHPGFRALLEGIRARNERQEEEGDPEPGNQQPLVEEPQHVRVVREAGEQYALARGEVFQKVHVKLRLNLCLQDLADRLKIANSTASKYVHTWVSGMHQIFVHRPTNFRERVSTFSSYKNHNTIKFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9HMZ1</accession>
    <name>E9HMZ1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_115919</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Basu M.K."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kultz D."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="224" mass="26010" checksum="5441D5A355F9949F" modified="2011-04-05" version="1">MKKKRKKKKRKKEEEESEKEESGKEDEEEDKEVENNDEISNKNNGKITDLNKKRQSDVAGQEPETFIDGNTLEEQERPNQNRFKQKAIKPAEIGTQPVLNVQKGEKEKHVTAIQETNRRIFYWIQNGEEEEKEEREEDSPYVFFCENCEEDLDNWSRQPTGAATEKKNGEKEEPEPKRSRQDEDNGGDAEEPEPKRQRIANFDNSGVEKSKPSTSGTIPPNVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
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        <name type="common">Water flea</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
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                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="119" mass="13095" checksum="DC0F9C9EF3AC3C22" modified="2011-04-05" version="1">MVNNKKCGENAMQAGATTLSFTASPVGEGKWYATREYHALNCLVEEITLRQDTTEGPIESPFGMLNATQTDHQITYNHNTIVWGDLTMTDSGTTSLLHGQAYLELTHWDGTYQPQSPSG</sequence>
</entry>
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    <accession>E9HU55</accession>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 7 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000000305">
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    <dbReference type="GO" id="GO:0032039">
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        <property type="evidence" value="ECO:0000318"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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    <accession>E9HV76</accession>
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            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="20" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="201" mass="23369" checksum="F5D4D61FC48F3F3D" modified="2011-04-05" version="1">MGSESPDVWPRTAEISFGSTEVTRHEFYECFEHESIESDCIFDAVCRLPGRAFCVFRIGFKTVKDHIKFLDKFSAKESVVISGKEVRIRVRDRSVNLVRVRIQHFKFDDDLSLLNKRLREYGVISRIFWDTYQDRSLPRWNGIKTGVVNVDMEIHKSIPSYITFGSYKEPIMVSYVGQMQTCRMCDSPTHVLANCPKQPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9HXV7</accession>
    <name>E9HXV7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bifunctional lysine-specific demethylase and histidyl-hydroxylase</fullName>
            <ecNumber evidence="5">1.14.11.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_268482</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROX family. NO66 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="5"/>
    <dbReference type="EMBL" id="GL733079">
        <property type="protein sequence ID" value="EFX63430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX63430"/>
    <dbReference type="EnsemblMetazoa" id="EFX63430">
        <property type="protein sequence ID" value="EFX63430"/>
        <property type="gene ID" value="DAPPUDRAFT_268482"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_268482"/>
    <dbReference type="eggNOG" id="ENOG502S0FU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1360194_0_0_1"/>
    <dbReference type="InParanoid" id="E9HXV7"/>
    <dbReference type="OrthoDB" id="1272760at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3-di/monomethyl-lysine-36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039994">
        <property type="entry name" value="JmjC_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096">
        <property type="entry name" value="PTHR13096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="Cupin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX63430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="226" mass="25219" checksum="A6C7A5F5CA92282C" modified="2011-04-05" version="1">MLQHADLKILAEFVKTEEWVLEPGDMLYLPPLLAHCGTAEDDCMTYSVGFRAPSAAEVLTHFTDFLGQFLPDEERYSDADAQPTSDPTQIQRDALDRLKALLTEHMSDERLLMTWFGQFMTEPKYPELIAGIEIDEEGFLGSLENGAILIRNPSARMAWSEVGDDLVLFASGQSRLLSASLRELLKLVCAADALHIENLSAWLADDEGRNLLVELVKQGSLEFADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZS3</accession>
    <name>E9HZS3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_119886</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733400">
        <property type="protein sequence ID" value="EFX62757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62757">
        <property type="protein sequence ID" value="EFX62757"/>
        <property type="gene ID" value="DAPPUDRAFT_119886"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_119886"/>
    <dbReference type="HOGENOM" id="CLU_1190899_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HZS3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX62757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="233" mass="25468" checksum="F31E136CC1143CBB" modified="2011-04-05" version="1">MSLSRKPTMIGLHCFHNNCSSALFALFPVSLNHGRVISLVESIKVFHYLFFSEILMEERRERDETMSGENRRVAAISWSSTGFASTRKDLPPPKPSRVPATYVGIGESAGKSVPSASSEQSLSGPMTYLVAPNSEVLAQLMCDIKTRGDAGHYTSPAPAFNRFTVEFCYTSSSNSNPASPQHKCKTKGRKNQPVYANIMMADATPPSEAAVVATNSAPYKIVRMSACRVEHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2M7</accession>
    <name>E9I2M7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_271965</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734165">
        <property type="protein sequence ID" value="EFX61753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61753">
        <property type="protein sequence ID" value="EFX61753"/>
        <property type="gene ID" value="DAPPUDRAFT_271965"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_271965"/>
    <dbReference type="HOGENOM" id="CLU_1972703_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX61753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="127" mass="14703" checksum="144F16DA8EB3EA32" modified="2011-04-05" version="1">MANPGHYDQMRDAPTERNNQFFNRSMPSGNQRITTSPIFKMLSVHLMFISRQIPLKSIFKWSKVQVPGRAIVPQCNNQVLISQLLDDKFLGARQPPRRRLEKGRPKSGASHTRFDHGHVESYWKTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9I743</accession>
    <name>E9I743_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_344855</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL736924">
        <property type="protein sequence ID" value="EFX60187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60187">
        <property type="protein sequence ID" value="EFX60187"/>
        <property type="gene ID" value="DAPPUDRAFT_344855"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_344855"/>
    <dbReference type="HOGENOM" id="CLU_2051934_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX60187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="120" mass="14035" checksum="B49AC2900FB40D46" modified="2011-04-05" version="1">MSRQIRAGPLSTSAASAKTHSSKLFLPKIRHFLSKSNSNDKEEKKYIEIEIKEEEDQIALNTEIEEEHKYDIETKRINYRLNSKKRTKNIIESLMKQSHAIPKKQESLSTSFRFNNVLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9I7I3</accession>
    <name>E9I7I3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_125694</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL737243">
        <property type="protein sequence ID" value="EFX60047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60047">
        <property type="protein sequence ID" value="EFX60047"/>
        <property type="gene ID" value="DAPPUDRAFT_125694"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_125694"/>
    <dbReference type="HOGENOM" id="CLU_1580081_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX60047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="169" mass="18714" checksum="E40383AE4E5F406C" modified="2011-04-05" version="1">MWKKQMLANKNKTNDPPKPADNVPSLSHRPPPTPTLPRGLKIISPPWAKQGQDASNNNPNKTNTTVPASQNPPANQPAWMKGNSNVQETSPGWANKNAGSSPQANWANKGGVGQTAPPNPPWMKSGETSVPQNSNLQRAQKIADMEKEKKEMEEKQRLLEEEERERKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9FQP6</accession>
    <name>E9FQP6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_39988</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX90025">
        <property type="protein sequence ID" value="EFX90025"/>
        <property type="gene ID" value="DAPPUDRAFT_39988"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_39988"/>
    <dbReference type="eggNOG" id="KOG3624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006187_1_1_1"/>
    <dbReference type="InParanoid" id="E9FQP6"/>
    <dbReference type="OMA" id="WCANTRT"/>
    <dbReference type="OrthoDB" id="282463at2759"/>
    <dbReference type="PhylomeDB" id="E9FQP6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M13" evidence="1">
        <location>
            <begin position="3"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX90025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="193" mass="21992" checksum="35742F013B09D76F" modified="2011-04-05" version="1">MSFIHLSIPRYMTYGNLGVVIGHEIVHGFDVNGRRYDRHGNMTQWWSESLMREFSQRADCFIQQYAAFTIDHIDKPIDGNRTLGENVCDSGGLAHAWTAYKSNSKSGGEEIRSPEYRLPGVNYTDDQLFFITYGQIWCEVLNGDGYEKYTKEAHSPGKYRANGVLQNSPTFSQVFNCPLDSPMNPANKCQLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9FQV3</accession>
    <name>E9FQV3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_300107</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Rechtsteiner A."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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</entry>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="HOGENOM" id="CLU_128937_0_0_1"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TCO</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="SVE85193.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX89576">
        <property type="protein sequence ID" value="EFX89576"/>
        <property type="gene ID" value="DAPPUDRAFT_303041"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303041"/>
    <dbReference type="eggNOG" id="KOG4514">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="1567231at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="P:lysosome localization"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019314">
        <property type="entry name" value="BORCS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13440">
        <property type="entry name" value="PTHR13440"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BORCS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
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        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SVE85193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="284" mass="31005" checksum="852FA3C83770DD77" modified="2011-04-05" version="1">MSDSENESNSESLQHDLMSVSDQEDDGSRDGDDMLSAEIDISEVHEQAPSREDDSIPTDSTSNEDLAQLPGEEGPSDKVEGKLPLRDLAGLDEAALELGMSGSYSEIRSPSRFKIEPVPEEEVKPSIQNLAIEGTVLKEGDMIHFIAKNLETKIRLSSPDISESSQLLAAQSELAKQHQSVATPESTFLAQLERDARCIAASVDGLTEHLVSSLHTISAVTAQSLTVYKDSVCKTCDAMDGNIKSMYQLMAKCEELSKAMTPIYKLSEQVKEIKKLLDIMENLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9FWG4</accession>
    <name>E9FWG4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_311292</name>
    </gene>
    <organism evidence="4">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Koonin E.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Andrews J."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="580" mass="65665" checksum="3D5B403A16510834" modified="2011-04-05" version="1"> </sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87710">
        <property type="protein sequence ID" value="EFX87710"/>
        <property type="gene ID" value="DAPPUDRAFT_312102"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312102"/>
    <dbReference type="HOGENOM" id="CLU_1887836_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX87710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="135" mass="15416" checksum="EAF19373F0A32CE7" modified="2011-04-05" version="1">MTVQKQTSLAFRLSRFEFLTLWLNKSYVTRKISPVIFETPSDRRCFLPCRNSQSEWFQVDPRVSDGNTFQTNGTLSEDENKTHLIHKAASAPLVRAKGKPRQIFRATMGGAQPGFDVRTPGNLAKKIENNMNFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZ55</accession>
    <name>E9FZ55_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_306464</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87652"/>
    <dbReference type="EnsemblMetazoa" id="EFX87652">
        <property type="protein sequence ID" value="EFX87652"/>
        <property type="gene ID" value="DAPPUDRAFT_306464"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306464"/>
    <dbReference type="eggNOG" id="KOG3865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033484_1_1_1"/>
    <dbReference type="InParanoid" id="E9FZ55"/>
    <dbReference type="OMA" id="MGLNFQK"/>
    <dbReference type="OrthoDB" id="783081at2759"/>
    <dbReference type="PhylomeDB" id="E9FZ55"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017864">
        <property type="entry name" value="Arrestin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="PTHR11792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00295">
        <property type="entry name" value="ARRESTINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin_C" evidence="3">
        <location>
            <begin position="191"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX87652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="388" mass="43005" checksum="F47E431C482CEF13" modified="2011-04-05" version="1">MVYALKVFKKTSPNSKVTVYLGKRDYIDNITKIESVDGVALIDPEYLKGRKLFGQIVCSFRYGREEDEVMGLEFQKDLLMASGEIRASQKSDLTKMQERLIKKLGSNAFPFIFELPKNAPPSVTLQPGSEASGKPCGVEYFLRIFVGESMDDRAHKRSSISMGIRVIQFAPSQGQQGRQPCTVVRRDFVLSPGDLEMEINLDKQLYHHGDPIAVNVVIQNRSNKTVKKLRAQVLQCIDVCLFEHGSYKTPVVTLDTSEGCPIPPGGTLHRTYTLTPRLGAAVADRHGVALGGRLRDEDTELASTTLMANPDDRDGFGIVVTYLIKVRLFLGALAGELVGELPIIMMHPKPNPKKLPRMDSVAFETFGSNSVDDAGQDLDRMKLDDVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9G114</accession>
    <name>E9G114_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_312931</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86716">
        <property type="protein sequence ID" value="EFX86716"/>
        <property type="gene ID" value="DAPPUDRAFT_312931"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312931"/>
    <dbReference type="HOGENOM" id="CLU_529204_0_0_1"/>
    <dbReference type="InParanoid" id="E9G114"/>
    <dbReference type="OrthoDB" id="1292766at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031620">
        <property type="entry name" value="DCAF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14815">
        <property type="entry name" value="PTHR14815"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15802">
        <property type="entry name" value="DCAF17"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX86716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="515" mass="58479" checksum="6BAAEFC5FB02C651" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1H0</accession>
    <name>E9G1H0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_97485</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
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                <person name="Thomas W.K."/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="TGT" evidence="1">
        <location>
            <begin position="168"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX84377.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX84383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="335" mass="37068" checksum="7E92DE6332EDEF21" modified="2011-04-05" version="1">MKFAVYLVAESSARLGSLTEFARIPEAVFETPLLLLHTRGASVPHLSYDLLQMVSTGHYMLQMPLVTLVDHTKNVKAFGKGIAEFAGLKIVDIGYHEKNSISPWTRGGRKLIDPQTYNISCIEALKPDMFQAIVDGDTTQSSSAKRVRKSVDVTVKFAGICADLKEKSDGSLSENLPRAFHGPITPIVLLKLVSKGIDILDGTFPWLVAERGSALVFPNSLSKENAPVTETLPSVKAPAVVATDQKVTKLADDNSNKEAVDRVYEINLKDKIYFSDTRPLLEGCSCYSCRKYSRNYVHHLTATGELQGPILIMMHNFHHYINSFKSIQQAIKDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9G783</accession>
    <name>E9G783_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX84421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_238722"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238722"/>
    <dbReference type="HOGENOM" id="CLU_2017480_0_0_1"/>
    <dbReference type="OrthoDB" id="1256412at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="123" mass="13449" checksum="B4BA8CC5945938B8" modified="2011-04-05" version="1">MSRHCFTALHSLTEGIGLQSGQEITESRFVAELQQQLVTSVESGVKSHKQGSIPSFNSNSVQVNLGNSGHLNQDLISPPTPYSGYAKTLTLSQNALKHSTQTHMPREAESNKRSKNVVPQYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7I8</accession>
    <name>E9G7I8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_301092</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84634"/>
    <dbReference type="EnsemblMetazoa" id="EFX84634">
        <property type="protein sequence ID" value="EFX84634"/>
        <property type="gene ID" value="DAPPUDRAFT_301092"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301092"/>
    <dbReference type="eggNOG" id="ENOG502RYSE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="SRICLEP"/>
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    <dbReference type="PhylomeDB" id="E9G7I8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
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        <property type="entry name" value="PTHR15887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="208" mass="22800" checksum="255A495206E6250B" modified="2011-04-05" version="1">MLLIQKIVNPLGNSSRYLRWNSVCLAVGTSTRKLHLSRPNESVFGEDAKNALRNFGDIKHTPIPALTYGIGGLIPFTAIPVYMLSSGVYIPEMAFTSMAYSAVILSFIGGVRWGSAVSNPEIMNPNWKNFTSSIAPSIVGWMSLLVSNPIGTLLSISGFSLCLLQDMTSSQFPSWYKSLRILLSTVAICALLTTFMCQFLLPLEPKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAS0</accession>
    <name>E9GAS0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="2">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_48121</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + N(6)-D-ribulosyl-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fructosamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="2"/>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83493"/>
    <dbReference type="EnsemblMetazoa" id="EFX83493">
        <property type="protein sequence ID" value="EFX83493"/>
        <property type="gene ID" value="DAPPUDRAFT_48121"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_48121"/>
    <dbReference type="eggNOG" id="KOG3021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036517_0_1_1"/>
    <dbReference type="InParanoid" id="E9GAS0"/>
    <dbReference type="OMA" id="GSFYSAY"/>
    <dbReference type="OrthoDB" id="943202at2759"/>
    <dbReference type="PhylomeDB" id="E9GAS0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="PTHR12149"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX83493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="301" mass="34770" checksum="992FE7F5C69F8BD6" modified="2011-04-05" version="1">MAEYREIIASELKLKKIDPWKRIGGGCSSNNWAFKTDIGEIFAKICSDENGKDILLGEFKSLEMLQMTNAVRVPKPIKVVSSYNTTILITEYIQFRGLKVFQGELGHQLAILHLKNLELLKINSDQAVRQFGFYVNVCCGLLPVENQWNGNWTDFYCKQRLKPQIKNVAQKSGNKEVERLWSLLEPKIVQLFDGVTVFPSLLHGDLWSGNVGETNDAPVIYDPASFYGHHEFDLAITRMFGGFSKEFYEKYHQLIPREKGFEERKPLYELFHYLNHWNHFGGGYEEQSLGIMRKLIKLIHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9GC94</accession>
    <name>E9GC94_DAPPU</name>
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        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_316237</name>
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    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX82900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82900">
        <property type="protein sequence ID" value="EFX82900"/>
        <property type="gene ID" value="DAPPUDRAFT_316237"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QVEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007156_0_0_1"/>
    <dbReference type="InParanoid" id="E9GC94"/>
    <dbReference type="OrthoDB" id="1369029at2759"/>
    <dbReference type="PhylomeDB" id="E9GC94"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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    </dbReference>
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        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
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    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="1175"/>
            <end position="1213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX82900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1216" mass="138805" checksum="2C675343C7906C3D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GE36</accession>
    <name>E9GE36_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2148333_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GE36"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX82201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="112" mass="12271" checksum="CFAF91CF3CC4860E" modified="2011-04-05" version="1">MPSAVIKKGTDAGYHLQKDRCGILEVLLTDNQLRARSFFMESCGPGTEILVPMLTFVHDGRGTSINVLPHPFLRDACSSSFTGSKHNLLYYTGDLASFWTTSVIASVPLLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GH30</accession>
    <name>E9GH30_DAPPU</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732544">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81262">
        <property type="protein sequence ID" value="EFX81262"/>
        <property type="gene ID" value="DAPPUDRAFT_242616"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_242616"/>
    <dbReference type="HOGENOM" id="CLU_156088_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GH30"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX81262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="135" mass="14989" checksum="832ACF5AD7D4EB1E" modified="2011-04-05" version="1">MSNATLGVLNRHLRLEVRHVFGLLKAIMARMKGDDIFGGRIPEGWTTMMPEHLAQLSSQKLRADTQPGDGVLETLLQMVNIVSTSQPVPVDLSPDNSLLYTIRQIEGPEWDGIPAELKMEHLGHVLLIAESLDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GH47</accession>
    <name>E9GH47_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_102673</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732544">
        <property type="protein sequence ID" value="EFX81254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81254">
        <property type="protein sequence ID" value="EFX81254"/>
        <property type="gene ID" value="DAPPUDRAFT_102673"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_102673"/>
    <dbReference type="HOGENOM" id="CLU_1580099_0_0_1"/>
    <dbReference type="OrthoDB" id="1358897at2759"/>
    <dbReference type="PhylomeDB" id="E9GH47"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX81254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="169" mass="19424" checksum="B47E43DBBBFD825C" modified="2011-04-05" version="1">MVHAFKHIWNLGGRYTYKILYDNMPVVFPSPTRIKINLEKYNPSCVPGVIFLETLLDIIKENNYPNKVLISEDEIAIISKTEYHPWYNSILGESLLLRDTVLPDPDPPSGWEILIPHQDLSGDLFLVDKMNLSAAERILKPEVRQLLDEVLKGDSDGTSFYLEMMYLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9GHX7</accession>
    <name>E9GHX7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_318119</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732545">
        <property type="protein sequence ID" value="EFX80972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80972">
        <property type="protein sequence ID" value="EFX80972"/>
        <property type="gene ID" value="DAPPUDRAFT_318119"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_318119"/>
    <dbReference type="eggNOG" id="ENOG502S4KI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075165_4_0_1"/>
    <dbReference type="InParanoid" id="E9GHX7"/>
    <dbReference type="OrthoDB" id="1583175at2759"/>
    <dbReference type="PhylomeDB" id="E9GHX7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012903825" evidence="3">
        <location>
            <begin position="16"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX80972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="225" mass="25435" checksum="82C1888F49A744BE" modified="2011-04-05" version="1">MKVFIIAALMVVVSGQSYKPSSYPVAPYKPEYPAPGYRPSYPAPAYKPSYPEYKPEYKPSYSPPAYPAYPAQQNYDYPPMPYKFEWAVKDDYTYNDYAHEETSDDKGYVTGSYRTLLPDGRTQIVNYKADDYTGYVADVKYEGEAKYPEYKPSSYKPSYAPAYPSPAYPSPSYPSPAYPSPAYNKPAYPKPSYPSPSSYPAPAYKPAYPPAKYPAYPAPKYPAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9GI59</accession>
    <name>E9GI59_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DAPPUDRAFT_50984</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732546">
        <property type="protein sequence ID" value="EFX80619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80619"/>
    <dbReference type="EnsemblMetazoa" id="EFX80619">
        <property type="protein sequence ID" value="EFX80619"/>
        <property type="gene ID" value="DAPPUDRAFT_50984"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_50984"/>
    <dbReference type="eggNOG" id="KOG1306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012872_1_0_1"/>
    <dbReference type="InParanoid" id="E9GI59"/>
    <dbReference type="OMA" id="VSAETEM"/>
    <dbReference type="OrthoDB" id="490546at2759"/>
    <dbReference type="PhylomeDB" id="E9GI59"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015491">
        <property type="term" value="F:cation:cation antiporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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        </citation>
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        </source>
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        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Daphnia pulex</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Tsuchiya D."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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    </feature>
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        <source>
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            <dbReference type="EMBL" id="EFX78437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="656" mass="73959" checksum="00BC23B5EEE903C1" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQ13</accession>
    <name>E9GQ13_DAPPU</name>
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        <submittedName>
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    </protein>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732557">
        <property type="protein sequence ID" value="EFX78495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78495">
        <property type="protein sequence ID" value="EFX78495"/>
        <property type="gene ID" value="DAPPUDRAFT_246297"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_246297"/>
    <dbReference type="HOGENOM" id="CLU_1671106_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX78495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="158" mass="17368" checksum="006CBEAB61906210" modified="2011-04-05" version="1">MAKRSQENRAEATKSAGEDDKLLHPRRKGFAGIDHWRPRTHPTSRFQAMDYTRSGGGYGPKPGLHGQNTIRPNFSAKSPYAPQKNGGNAGNDSTSRKRTSSSSGTNSTNPYHRKSSADHNTAGEENGRAARPVSWSRARPRTRPDSTHTPVNPHQRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQ33</accession>
    <name>E9GQ33_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_105505</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732558">
        <property type="protein sequence ID" value="EFX78243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX78243">
        <property type="protein sequence ID" value="EFX78243"/>
        <property type="gene ID" value="DAPPUDRAFT_105505"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_105505"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_7_6_1"/>
    <dbReference type="InParanoid" id="E9GQ33"/>
    <dbReference type="OrthoDB" id="1522379at2759"/>
    <dbReference type="PhylomeDB" id="E9GQ33"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241192" description="Peptidase S1 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="260"/>
        </location>
    </feature>
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            <begin position="67"/>
            <end position="260"/>
        </location>
    </feature>
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            <end position="145"/>
        </location>
    </feature>
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            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX78243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="260" mass="29149" checksum="1A293E116E6D115F" modified="2011-04-05" version="1">MAKPFQSRPAVVFLIAALQFYFDPANSAGSRMHKNKRFVPTLDEITLNGWQAPEQLEESNSSQQTRMVDGDATRKNQFPYMVALMRLRSTRPQVWDIAYCGGSLISSTHILTSANCVLRYRRRQKKDKDQRRPIDEKHPPNQNPREIRYVQSGSIKDQYEGELAIVKGWGDTGVNGTSPGVLHHAVKKIISNSKCRESNIPSTVFDHTLCAYRRGKHFCGKGDAGGPLVIESDNANSQQPEGHNQTCHWIQVAIASWGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQ78</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="3">
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        <lineage>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732558">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX78394">
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        <property type="gene ID" value="DAPPUDRAFT_105310"/>
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    <dbReference type="GO" id="GO:0004252">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Peptidase_S1A"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRYPSIN_DOM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="109"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX78394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="360" mass="38597" checksum="3D11D5538F49E060" modified="2011-04-05" version="1">MSSDRKVADVGYAPSYHGKTLYGQIASPGFVPLPSFNPHPGMAYRQQQQDPNGWSYSFGYPNLIPPADVSPIRQVVAPPTTTTTPAPAIQCGKGPTTLPASRSFISERILGSGVTAAKANAWPFMVALRKYTDNPILLAAGINYDDFCSGTLISDSKVLLAATCLEKMSLYEMSGVTVAAGLTFNSDTNIADAQMTRRISKVVLHGQYNAFTYANDIAILTLDSPLVISRTVGPVCLEPANAALDQYADQDAVILGWATTSAKIPFGSLKQGTVSVSFNSECKADEIFGKYVTNANICIITSSVQKYFCDEDVGGPVVVLSSPGIWTQIGINSFIKKGCDIAGLQTRVSAFRAWIDQYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQN9</accession>
    <name>E9GQN9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">(S)-3-amino-2-methylpropionate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.19</ecNumber>
            <ecNumber evidence="3">2.6.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-AIBAT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_213117</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="4"/>
    <dbReference type="EC" id="2.6.1.22" evidence="3"/>
    <dbReference type="EMBL" id="GL732558">
        <property type="protein sequence ID" value="EFX78146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78146"/>
    <dbReference type="EnsemblMetazoa" id="EFX78146">
        <property type="protein sequence ID" value="EFX78146"/>
        <property type="gene ID" value="DAPPUDRAFT_213117"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_213117"/>
    <dbReference type="eggNOG" id="KOG1405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_12_0_1"/>
    <dbReference type="InParanoid" id="E9GQN9"/>
    <dbReference type="OMA" id="ATGKFWG"/>
    <dbReference type="OrthoDB" id="566705at2759"/>
    <dbReference type="PhylomeDB" id="E9GQN9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047298">
        <property type="term" value="F:(S)-3-amino-2-methylpropionate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003867">
        <property type="term" value="F:4-aminobutyrate transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042135">
        <property type="term" value="P:neurotransmitter catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="7 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX78146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="484" mass="54376" checksum="2BB7B8C42FEEF512" modified="2011-04-05" version="1">MFRSLLANNARYLSSAFVAGEPAGPEVKTAIPGPRSLAMLAEMKTIQISDAVQLFADYSKSIGNYLYDVDGNILLDVYTQISSVPLGYNHPELLDVLQDKENIRTFINRPALGVFPGENYPQRVYNSLLRVAPKGHTEVTTMACGSCSNENAYKAIFVWYRRKQRGDAPYTPEEETSCVMNQSPGVSDLTLLSFKGAFHGRTFGTLITTHTKPVHKLDIPTMDWPIGTFPRYKYPLEDFVRENEEEDRRCLAEVEELFERYNKRGKNVAGVVIEPIQSEGGDHHASPAFFQQLQRIAKKNGAALLIDEVQTGGGTTGEFWCHDHFNLEHPVDIVTYSKKMLVGGYFSLPEFRPREGYRIFNTWMGEPSKVVLLEKVIDVIKRDKLIENVKVTGDILLNGLKAFGKRYPNLVKNVRGRGTFCAFDCDSMAKRDQLVEQLKVEGVQTGGAGPVAVRLRPSLVFQPHHAAIFLDRLEKALHKMDNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQV0</accession>
    <name>E9GQV0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ecdysone-induced protein-like protein 63E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_299555</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732558">
        <property type="protein sequence ID" value="EFX78176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78176"/>
    <dbReference type="EnsemblMetazoa" id="EFX78176">
        <property type="protein sequence ID" value="EFX78176"/>
        <property type="gene ID" value="DAPPUDRAFT_299555"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299555"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="InParanoid" id="E9GQV0"/>
    <dbReference type="OMA" id="PTILTMP"/>
    <dbReference type="OrthoDB" id="1010560at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000083">
        <property type="term" value="P:regulation of transcription involved in G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="32"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX78176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="364" mass="41185" checksum="845F86B75B57861B" modified="2011-04-05" version="1" fragment="single">SAINLKPSESIRRSKRYSAFGGTSPFGKIENYLRLEQLGEGSYATVYRGFSNLTQQVVALKEIRLQEEEGAPFTAIREASLLRDLRHANVVTLHDIVHTKTSLTFVFEYVHSDLAQYLERHPGGLQAHNVRLFLFQLLRGLSYVHRRKILHRDLKPQNLLISEVGELKLADFGLARAQSVPSHTFSSEVVTLWYRPPEVLLGSTQYSSPLDLWGVGCIFVELLTGSPAFPGVKDAADQLERIFKILGTPTEATWPGVSRLPLYKPQRLNFYRTQRLGHAFPRLYDISQAENLASKLLQLQPSTRLTGETAVRHKFFQELPSQLFNLSDDVSIFTVPGVGLYPEERKFPPVVLRAAQELKNKAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GT05</accession>
    <name>E9GT05_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_106236</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732563">
        <property type="protein sequence ID" value="EFX77356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77356">
        <property type="protein sequence ID" value="EFX77356"/>
        <property type="gene ID" value="DAPPUDRAFT_106236"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_106236"/>
    <dbReference type="HOGENOM" id="CLU_1344489_0_0_1"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="PhylomeDB" id="E9GT05"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="204" mass="22851" checksum="E71B0EA2F01BB464" modified="2011-04-05" version="1">MGPEDEANRRPHRKKPCGSETQIPPVIIKLTDGKFTFMTMHIAERMRIQNEFIGAIGEPRESTVLMGGDLAVVAHNKNQQADLMALKNIIGRPVLCSLPNSASAYRTGHEQGDKDPNGRHGGCEREAQPHRRKIRRRLKATIGKRQIPDQQEEPRYRLLGADEKLCQPNGCLATSVYATTPHQVVECYFNTLSHSKQTTNTNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9GU11</accession>
    <name>E9GU11_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_106532</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732565">
        <property type="protein sequence ID" value="EFX77052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77052"/>
    <dbReference type="EnsemblMetazoa" id="EFX77052">
        <property type="protein sequence ID" value="EFX77052"/>
        <property type="gene ID" value="DAPPUDRAFT_106532"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_106532"/>
    <dbReference type="eggNOG" id="KOG1474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_597527_0_0_1"/>
    <dbReference type="InParanoid" id="E9GU11"/>
    <dbReference type="OrthoDB" id="1162133at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040214">
        <property type="entry name" value="KIAA2026"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31095">
        <property type="entry name" value="PTHR31095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="SSF47370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="206"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX77052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="458" mass="52076" checksum="D26111D4B378C11D" modified="2011-04-05" version="1">MDQGPVGAVEECFSVGAEEMVAHSEEVVTSNEIITNPPPVPTTTQQLPQAQAQPSTVYNIPTVIASPGPIMQVVTLQTVQQPSAAQVGLTNALRNIRLIAIQPKLPLNGTNGRAQPISLQPSPKPQVKIQPQLSSDPNKKVTVNSFYSKKPSQPVILAPKQPQHVVKPSPSFYKEQQREREMKEFAHLSEELQRGLRIFLDLTISLHHNTTWPFMEQVDPVKDGAPDYHQVIKKPMWLKLIKEKFRKNQYSSISDFVSDMRLILENCYRYNGPNHPITKKALRLEQSLEQKLALLPSDLRSKCALAEADSERKARPGSSDAYFSVLLHRVRHEREQREQLLKEKRAEEQRLKREEKERQRCLWAERMMNPEVKAQMKTMWEIPQIGHFLHLARGALHIGEIAQYELEHMFLMPEASALLATLMTSLLSSPNQRVKLAESPPTPYAVWSAKVENNFNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9GU42</accession>
    <name>E9GU42_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_225892</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX77041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77041"/>
    <dbReference type="EnsemblMetazoa" id="EFX77041">
        <property type="protein sequence ID" value="EFX77041"/>
        <property type="gene ID" value="DAPPUDRAFT_225892"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_225892"/>
    <dbReference type="eggNOG" id="KOG2328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010510_1_0_1"/>
    <dbReference type="InParanoid" id="E9GU42"/>
    <dbReference type="OMA" id="KPKAKMG"/>
    <dbReference type="OrthoDB" id="702078at2759"/>
    <dbReference type="PhylomeDB" id="E9GU42"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="PTHR13108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX77041.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
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    <sequence length="721" mass="80381" checksum="D4A876F282A89B80" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GUH8</accession>
    <name>E9GUH8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_248606</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX76835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_248606"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_248606"/>
    <dbReference type="HOGENOM" id="CLU_2560607_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX76835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="82" mass="9334" checksum="A11A86B7E125DEA6" modified="2011-04-05" version="1">MQPVLIQLIKTTKITVGCRTKTSRRLKEAVARLPEDKRKAIEEEDRALADNARIAHESSLSAREVPKRKAIIHKEVLLDYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9GWR8</accession>
    <name>E9GWR8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcriptional factor Homothorax protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HTH</name>
        <name evidence="6" type="ORF">DAPPUDRAFT_347503</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="3">Nucleus</location>
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        <text evidence="1">Belongs to the TALE/MEIS homeobox family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX75948"/>
        <property type="gene ID" value="DAPPUDRAFT_347503"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG0773">
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0009880">
        <property type="term" value="P:embryonic pattern specification"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Homeobox_dom"/>
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    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="Homeobox_KN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032453">
        <property type="entry name" value="PKNOX/Meis_N"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="349"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="3">
        <location>
            <begin position="351"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="229"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="479" mass="51066" checksum="456C84701AFDEBC6" modified="2011-04-05" version="1">MEMYGDPHAAHRSALASSHSHHSVSVSPASAAAAAAAAHLNSHGAAAAAAAAAAMHHSAAAAAAAAAQQHSQSPYHSLGNHAQQVGANHMTSSAASSSVPDVHKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNEDIAVFSKQIRQEKPYYIADPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGTSKPDLGDTNNNSGAHHARASTADTSHTDGSSTPDVRPPSSSLSYSGPGNDDTRSPGSVGGTPGPLSAAPPLSQQSVDNVSEAGKQWNQWTRREERTRCYSGDASNASIGSGDGTGEDDDDSNSKKNQKKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVALYPAGPSGAYSPDGGGMGYMMDGGAAAAAAMMHRPPADPMAFHSEYHYPPQYYGHHL</sequence>
</entry>
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        <name evidence="2" type="ORF">DAPPUDRAFT_322708</name>
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        <name type="scientific">Daphnia pulex</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX75952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75952">
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        <property type="gene ID" value="DAPPUDRAFT_322708"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2888023_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="63" mass="7115" checksum="0C9EA776A4D4819D" modified="2011-04-05" version="1">MAINIGYSCKVLADDMVEIFIANGHKSEDVKLRPEKSKESLSNDNEDSNTVYTTHWSTPCKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Daphnia pulex</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732572">
        <property type="protein sequence ID" value="EFX75842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX75842"/>
        <property type="gene ID" value="DAPPUDRAFT_107503"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="583605at2759"/>
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    <dbReference type="Proteomes" id="UP000000305">
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    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
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    <dbReference type="Pfam" id="PF03732">
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        <property type="match status" value="1"/>
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            <begin position="342"/>
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            <begin position="1"/>
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            <begin position="268"/>
            <end position="288"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="540" mass="61272" checksum="90DBEB22D2CDF914" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="16" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX75806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX75806"/>
        <property type="gene ID" value="DAPPUDRAFT_249899"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_249899"/>
    <dbReference type="HOGENOM" id="CLU_1257207_0_0_1"/>
    <dbReference type="OrthoDB" id="1357584at2759"/>
    <dbReference type="PhylomeDB" id="E9GXH5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="187" mass="21134" checksum="9C93A9EC67A655E9" modified="2011-04-05" version="1">MTQMSIDPSPCNVKIQKERPVCMSLTLEGHGDHYVKRAMQWCRDPSPSNVKMQKERPVCMSFIIEGHGDHYSTLRCAAVGCCIVDGSLTTGVLMSPGYGGYQATAAKEHYTTSPPHYKTMLTYLLHRGPQYTTEASEYYTKTYAAPSYWEEKERHTHPQKLHPAKGKGSPPFLHIRSKLWRRAAVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GXN9</accession>
    <name>E9GXN9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_249987</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
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                <person name="Dusheyko S."/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Souvorov A."/>
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                <person name="Vos H."/>
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                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <name evidence="2" type="ORF">DAPPUDRAFT_109227</name>
    </gene>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX74169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012542346" evidence="1">
        <location>
            <begin position="16"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="141" mass="16802" checksum="30A3086705461559" modified="2011-04-05" version="1">MKVLIIAALIVAVVADQAPYYQSSYSPYPEYKPEYKPEYKPEYKPEYKPEYKPEYKPEYKPEYKPEYPTQRPYYAEPAYKPTYPEYKPAYTEHKPAYHEPTYAHPAPAYKPAYKPAYPEYKPTYSSPPQYLSYAPTYPVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2T7</accession>
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            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX73953">
        <property type="protein sequence ID" value="EFX73953"/>
        <property type="gene ID" value="DAPPUDRAFT_200344"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_200344"/>
    <dbReference type="eggNOG" id="KOG4600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="NILAIQC"/>
    <dbReference type="OrthoDB" id="1177118at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
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        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="142" mass="16012" checksum="6943530D4C4E86B9" modified="2011-04-05" version="1">MSLLTQILTNLQPCKTLNSTVRWASKKAGGSSRNPKGHAPGKRRGIKTQDGSKVTQSSILLRQLHIRCHPGLNVGMGKDGSLYALQPGRVLITCEKFEPNFDKYWTNKAYGSRKENMNNVYKKYFHVIPEPLEPKFKLVDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5X2</accession>
    <name>E9H5X2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX72862"/>
        <property type="gene ID" value="DAPPUDRAFT_253906"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_253906"/>
    <dbReference type="HOGENOM" id="CLU_2252754_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
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    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX72862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="104" mass="12025" checksum="0A0DD5F2504F1E9D" modified="2011-04-05" version="1">MSLDYGHLPEFGYRDNSADEEGSENEGLQGDEDSDYKDEKEDNEGEQGDEEGEGPQQESNSNQLKRNARKLSYFDNKRKKKMKLETNLMRVGFQVQHSRPFETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9H7A7</accession>
    <name>E9H7A7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_254546</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Koonin E.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX70280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70280">
        <property type="protein sequence ID" value="EFX70280"/>
        <property type="gene ID" value="DAPPUDRAFT_328221"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_328221"/>
    <dbReference type="HOGENOM" id="CLU_1671088_0_0_1"/>
    <dbReference type="InParanoid" id="E9HDB1"/>
    <dbReference type="OrthoDB" id="1314521at2759"/>
    <dbReference type="PhylomeDB" id="E9HDB1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
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        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb_DNA-bind_4" evidence="1">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="158" mass="18282" checksum="483218AD4DDD09D0" modified="2011-04-05" version="1">MEIFNDDFEKSTAPKKQLWKKVEKELKKAGFSSRSDVDCSVKWKNLKRHFFKLCRENTDSDKEENDWPYMESMTRVLKDNPTVTLENVTEVLDYSVKKKGKCNVAKQSKGKKEDFKGRMLDIEEKRAQSLAIIAESQRGKNEAINKIAMAIASLADRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDC9</accession>
    <name>E9HDC9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DAPPUDRAFT_328232</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="GL732623">
        <property type="protein sequence ID" value="EFX70267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70267"/>
    <dbReference type="EnsemblMetazoa" id="EFX70267">
        <property type="protein sequence ID" value="EFX70267"/>
        <property type="gene ID" value="DAPPUDRAFT_328232"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_328232"/>
    <dbReference type="eggNOG" id="KOG0432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_1_1"/>
    <dbReference type="InParanoid" id="E9HDC9"/>
    <dbReference type="OMA" id="HNIKSHF"/>
    <dbReference type="OrthoDB" id="229591at2759"/>
    <dbReference type="PhylomeDB" id="E9HDC9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="42"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="13">
        <location>
            <begin position="706"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="920"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFX70267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="989" mass="113257" checksum="896856AE739338FE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDD7</accession>
    <name>E9HDD7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_112897</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732623">
        <property type="protein sequence ID" value="EFX70233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70233">
        <property type="protein sequence ID" value="EFX70233"/>
        <property type="gene ID" value="DAPPUDRAFT_112897"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_112897"/>
    <dbReference type="HOGENOM" id="CLU_000680_39_4_1"/>
    <dbReference type="InParanoid" id="E9HDD7"/>
    <dbReference type="OMA" id="PTHIAGH"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="PhylomeDB" id="E9HDD7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="162"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="377" mass="42821" checksum="BBBBC5AAB052AA15" modified="2011-04-05" version="1">MAPFNQLFFSLRELNPSRLSAETLQVVRNYGIASVWSSRRGCRSGRRTKRKRATKKYLYCGLANARLLNSCQDALQHHLTISDLDLLLITETWLNEHNGDDILRDICPEGYVAIHRPRHGRRGGGVALIHRCTLRVNPLSINVEVASFEHLSVSIKINSVCINMVTVYRPPSTKPELFLEEFAGCLELLVAIPGRLLVVGDFNIHVDNLVSCKFISLIESFDLLQHVLDPTHIAGHTLDLVLTRREEHLLADCFVADQLSDHSAVHWILKANRPLRPRKSVTLRRLKTVDRGLLLSDLLDLPFVAAPAYETYTVRPDNPWMTEEILTARRNVRRIARRKRSTGLMIDKELLVTALSDLRQLISAAKVTFLNTKQHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HEJ3</accession>
    <name>E9HEJ3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_113270</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732629">
        <property type="protein sequence ID" value="EFX69868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69868">
        <property type="protein sequence ID" value="EFX69868"/>
        <property type="gene ID" value="DAPPUDRAFT_113270"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_113270"/>
    <dbReference type="HOGENOM" id="CLU_1653865_0_0_1"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX69868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="160" mass="17558" checksum="8C3283FA2D285D18" modified="2011-04-05" version="1">MTFAPLVMANGEQATLMGAATISVNHKMGTATGESVVFRMDGIDLILGNDFLKQYGKVQIDYREPTASINFGDQALAAITPQRTDHTKRGQRGYSSASFIGGELLFRTIKKTFRNQRCVGGTRVTGSQSNFRPVGHVVHWSTSVWIPVWTLESADTTEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9HF04</accession>
    <name>E9HF04_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_258230</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732632">
        <property type="protein sequence ID" value="EFX69693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69693">
        <property type="protein sequence ID" value="EFX69693"/>
        <property type="gene ID" value="DAPPUDRAFT_258230"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_258230"/>
    <dbReference type="HOGENOM" id="CLU_1534090_0_0_1"/>
    <dbReference type="OrthoDB" id="131264at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="PTHR15154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX69693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="175" mass="19947" checksum="74E40285C5473D81" modified="2011-04-05" version="1">MQLLDQIALAHPTVSLEIALYALFHRMYGMYPCNFLPLLLRHYSLRDNLHIFSHTVKPMVETVRIHPLLVTASKDIEIGTAKPSPPIPFFYISSPFHFEYGFERKRLFGRPLPMAYEHLQDQYASLLPFSFSLLLSSLEGCRQMGESLGLDSSKALDEMNSLNMAGCTKTPLRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HF83</accession>
    <name>E9HF83_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_328954</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732634">
        <property type="protein sequence ID" value="EFX69567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69567">
        <property type="protein sequence ID" value="EFX69567"/>
        <property type="gene ID" value="DAPPUDRAFT_328954"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_328954"/>
    <dbReference type="HOGENOM" id="CLU_593490_0_0_1"/>
    <dbReference type="OrthoDB" id="1823493at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX69567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="461" mass="51312" checksum="37BFA18AC1809FD8" modified="2011-04-05" version="1">MQEERRSALLAQHSAVVEIPKGAEWQGNHLMQGGAAVQFQQHPDSAAAADADAVLLPSVNKQPAELWGNQAGAQRSPSLESQGLTQPIQRPVEFQHPHQPFEQSSQQLSKPSKFTQQQQLIQNELPGNNFVEPLPFSSQQSLNKQQQQQQQPAGRFRKLNTQPGQETFKTSSAAQHRPDIGGQQFVAEPRPFVKVNAMPVESQRLTSDTFFQQLLPRVEPIPSHSNPSFRLIEAGQQIIDPRRLVEPPPQRGAFEPQQQQQQRFVRVNQPVTDPIKKEEPKQFASSQSNRQPQTLPQANQPLVQLQQQSARPLAGQQPIIADNHLRINQQRGPVLQTGPLQQRPVEPQRSAEPRKLDPRPLVKSNLLGESPQFIEPAKSSLGNLFEFDSSTDTQLAREQLAELIRLLAQSASQQQTDPNREATPNPSAPARSRQGESSNIVPFIAFSEPLPLEPASSNSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGQ3</accession>
    <name>E9HGQ3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_301190</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
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    </evidence>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX67256"/>
        <property type="gene ID" value="DAPPUDRAFT_218737"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
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    </dbReference>
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        <property type="term" value="P:protein O-linked glycosylation"/>
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    </dbReference>
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        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_trans_2-like"/>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
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        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 11" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
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        </location>
    </feature>
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        <location>
            <begin position="516"/>
            <end position="625"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX67256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="639" mass="72297" checksum="B011DDB58B3AFDF0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9HMX6</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_331611</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EFX66890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="184" mass="21119" checksum="E7F2548E8A85A637" modified="2011-04-05" version="1">MKAIVKAKSTIVFCDSHIESTEDVEENYIQELARIVWLPTGEYAYNCDRCFLTCNNSFVVGEEKDSTSSAHDVFEGKTLSGFCSICPEKCSLKMHFNQQFRWVKPEMKNNSSKSRPSAENKMRWSDMKSISSDQITMLQNHLKENGTTMLKHFQAAWGCLQHLNKNALHGTSFFTKRVFDILNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNL1</accession>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_14918</name>
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    <organism evidence="2">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Casola C."/>
                <person name="Choi J.H."/>
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                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Tang H."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66695"/>
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        <property type="gene ID" value="DAPPUDRAFT_14918"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_14918"/>
    <dbReference type="eggNOG" id="KOG2408">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:peroxidase activity"/>
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        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
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        <property type="entry name" value="Pxt"/>
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        <property type="entry name" value="An_peroxidase"/>
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    </dbReference>
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        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEROXIDASE_3"/>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX66695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="217" mass="23975" checksum="AA0BD3ED2ACF16EB" modified="2011-04-05" version="1" fragment="single">LYQEAKRILAAQMQHITFNEWLPIIIGRAKMQELGLLPLQQGSSQDYDKNLNPSVLNEFAAAAFRFGHTLIQGKHHGGDQGARNPVTPTLFQNAKIYTPGNLDKFLTGLASQPSQNAENFFTQEVTNHLFEEQGKGFGLDLVSLNLQRGRDHGIPGYNAYRTQCGLPPASQFKDLLNFISTAIVDKFAKLYETVGDIDLFIEAMSERLAPGALVGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNM8</accession>
    <name>E9HNM8_DAPPU</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732697">
        <property type="protein sequence ID" value="EFX66655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66655">
        <property type="protein sequence ID" value="EFX66655"/>
        <property type="gene ID" value="DAPPUDRAFT_331858"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_331858"/>
    <dbReference type="HOGENOM" id="CLU_2401862_0_0_1"/>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX66655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="93" mass="9942" checksum="73A360CEFF0FA966" modified="2011-04-05" version="1">MAITTAPLNTTSLSSSVSSQNPTTLNVIANPAIFSPDIRPTILSSAIPPSTQQKLKEKVVKTPLKGIVIKTPEGMFLQMSDGKDCYLSILKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9HP32</accession>
    <name>E9HP32_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732702">
        <property type="protein sequence ID" value="EFX66489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66489"/>
    <dbReference type="EnsemblMetazoa" id="EFX66489">
        <property type="protein sequence ID" value="EFX66489"/>
        <property type="gene ID" value="DAPPUDRAFT_64610"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG3535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="RALAYVY"/>
    <dbReference type="OrthoDB" id="65812at2759"/>
    <dbReference type="PhylomeDB" id="E9HP32"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF47">
        <property type="entry name" value="PTHR11232:SF47"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="1">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX66489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="157" mass="17603" checksum="E89B6533CBAB98BE" modified="2011-04-05" version="1" fragment="single">RFSGDGVTFRAKLIGVLEVNAPRGDRLCQEALGELKMAIKAAGEHKQRIIICIALDGLRLRDERTGDCLYHHAVHKISFIAQDMADPRAFGYIFGSPDQGHRFFGIKTDKHANLVVVAMRDLFQVVYDLKKKDVEKNKQYSFDGSGNKTVSNKNPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HQ78</accession>
    <name>E9HQ78_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_263676</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732716">
        <property type="protein sequence ID" value="EFX66106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66106">
        <property type="protein sequence ID" value="EFX66106"/>
        <property type="gene ID" value="DAPPUDRAFT_263676"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_263676"/>
    <dbReference type="HOGENOM" id="CLU_2544879_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX66106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="83" mass="9678" checksum="0BB0552D72652359" modified="2011-04-05" version="1">MKSVSHASEEYTFLSLSIVFLYALAKLTTVEITFKVYSDLWEEPIFGETSAIREQQTCYEELQVFMKKVVPEYFEKCCDPSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HR33</accession>
    <name>E9HR33_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_332837</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX65108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX65108"/>
        <property type="gene ID" value="DAPPUDRAFT_265211"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_265211"/>
    <dbReference type="HOGENOM" id="CLU_2148338_0_0_1"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="PhylomeDB" id="E9HT23"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="112" mass="12581" checksum="7139E6DEAC171412" modified="2011-04-05" version="1">MGVGTGAGHNGDDDASTSQTTFTSRLSKTLLNAPDTTIMDNVTKPIVKVLGELFSREDKKSIPTFKGKSMDKLITEWLKAAEHVARNNDWDDDQKIRFFSDRLKGEALEWHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HT50</accession>
    <name>E9HT50_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_265254</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732764">
        <property type="protein sequence ID" value="EFX65081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65081">
        <property type="protein sequence ID" value="EFX65081"/>
        <property type="gene ID" value="DAPPUDRAFT_265254"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_265254"/>
    <dbReference type="HOGENOM" id="CLU_2485587_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HT50"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX65081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="87" mass="9925" checksum="FA3A88B6339535F9" modified="2011-04-05" version="1">MLCRLLFVIRNVIAKTIVLEKEAIRDLAANVKDIDDDVSAVGLPNKQLYWVLVDEHFFESKAEIPTKPKLVGLIHLTKKAFKSQNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HTN7</accession>
    <name>E9HTN7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_265588</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732781">
        <property type="protein sequence ID" value="EFX64880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64880">
        <property type="protein sequence ID" value="EFX64880"/>
        <property type="gene ID" value="DAPPUDRAFT_265588"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_265588"/>
    <dbReference type="HOGENOM" id="CLU_840087_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HTN7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX64880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="331" mass="36582" checksum="0D2C01C406C3DA15" modified="2011-04-05" version="1">MDYSNLEYSATHEQATLPNLSFNNAVVEPSIGDIAIKIDPPIPIVVNHPAEINVCNVPVKLSSKERIAAAIDGRDVQWFVLDITALDRCLIGIHDDMKKLLSLINAQSDHQFKESDIMVANGIFLGSLEKRQTNLILIMENTSKKYPGKVHVCVTLPYRTTSASMIPNPQAVSFNYASALPSSSTSNSSNGNLSSTEPQSGFTASRQTGTVTKSKTPISVLRLYSVSNDVTFTMLADFVSQCGPLLHMQTEKSGINQTKTTFVELVVKPAVAKAFVDKWRGKCRLNNTNFAMYTSHFPYINNKTDKAKITIFCFKFSDLRDQQSLIYAQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E9HWA5</accession>
    <name>E9HWA5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3 6">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_118650</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3 6"/>
    <dbReference type="EMBL" id="GL732908">
        <property type="protein sequence ID" value="EFX63976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX63976"/>
    <dbReference type="EnsemblMetazoa" id="EFX63976">
        <property type="protein sequence ID" value="EFX63976"/>
        <property type="gene ID" value="DAPPUDRAFT_118650"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_118650"/>
    <dbReference type="eggNOG" id="KOG0741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008037_2_0_1"/>
    <dbReference type="InParanoid" id="E9HWA5"/>
    <dbReference type="OMA" id="FEHIDEM"/>
    <dbReference type="OrthoDB" id="197562at2759"/>
    <dbReference type="PhylomeDB" id="E9HWA5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <source>
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                <person name="Thomas W.K."/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
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        <property type="project" value="UniProtKB-KW"/>
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    </evidence>
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</entry>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX59948.1"/>
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        <property type="gene ID" value="DAPPUDRAFT_346233"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="76" mass="8461" checksum="89F12D9E3E794076" modified="2011-04-05" version="1">MLNFADCLLIVVGAIHQASVEDTVPHGEGVTKLMIYHFDQEINIQLTLILHSLLSFAAIAMLNDLFERNYACSVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX90420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX90420">
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        <property type="gene ID" value="DAPPUDRAFT_39484"/>
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    <dbReference type="eggNOG" id="ENOG502QUFU">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="PhylomeDB" id="E9FRU6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR46231"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="35"/>
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        </location>
    </feature>
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            <begin position="115"/>
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        </location>
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        <source>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="2 3" key="1">
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Pritham E.J."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="291" mass="32897" checksum="3664FDEAE1BC6779" modified="2011-04-05" version="1">MAFLICQIGCTNRIPKVAKDRRNQIGSKLFLRQEKQFFLYSIRSYSVQSGKGQHRRSHKLVIVDIHGPKDGNLYTTLKHLSIGNVHKDWPSGSISSQEWHREVAQPPRENTYHPAALSSSIKTSDILSDGRSDEILEEEFYDSSELFDEEEVELESTTFQHTTVAKPKSKDDISVPDREDEDETMEIQSAFTSGISNLPHRIEESGTGDKDKEQVNVKAPAATNQNTPTWKQLYPQLLAPVTPPCKRVIVAKEHPSFKPKVIDNHRVSNVLKADSVYARIQPSLRHRNGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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                <person name="Choi J.H."/>
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                <person name="Dusheyko S."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <source>
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        <source>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
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                <person name="Jogdeo S."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Membrane</location>
            <topology evidence="1 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX87992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87992"/>
    <dbReference type="EnsemblMetazoa" id="EFX87992">
        <property type="protein sequence ID" value="EFX87992"/>
        <property type="gene ID" value="DAPPUDRAFT_305492"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305492"/>
    <dbReference type="eggNOG" id="KOG3882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055524_3_0_1"/>
    <dbReference type="InParanoid" id="E9FX18"/>
    <dbReference type="OMA" id="VHKQGCY"/>
    <dbReference type="OrthoDB" id="1145558at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="PTHR19282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="113"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX87992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="239" mass="26121" checksum="1CBBDC40E446B6B7" modified="2011-04-05" version="1">MPGRFQSGWTLAFMKILLVFFDFALWVFGCAVLAAGIWMKFEVHKFLDVNPSNPVASHVAIFFMSVGVAIALVGLMSCYCTLSGNPILLYLYSAFLGVVLVIQISIGIAAFAYQDAIKESFKNGLKNSMKSYKNVEANRDAVDTMQTALKCCGVESYEDWQDYGLPVPNSCCKAQTCNTKNPSSINEVGCYTTVVTFISSSGKLIGIICLAVAGFHILGLVLTCMLASCINKWKYETII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXD8</accession>
    <name>E9FXD8_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_311607</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88285">
        <property type="protein sequence ID" value="EFX88285"/>
        <property type="gene ID" value="DAPPUDRAFT_311607"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_311607"/>
    <dbReference type="HOGENOM" id="CLU_1857288_0_0_1"/>
    <dbReference type="InParanoid" id="E9FXD8"/>
    <dbReference type="OrthoDB" id="264519at33208"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="138" mass="15774" checksum="521C7F1D9897B269" modified="2011-04-05" version="1">MSILIKDCVGNVCDRFATLTKKDGKIDAKMTFCAFSMDVIPRCAFGVKIDSLGKKVMYPDFVSFCVEGLSVTKEMTFFFDLLANILQERSQSEEKFIDFIELADESISDFMKEVDGKTVPLWSREEIDEIVKFMEFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYD6</accession>
    <name>E9FYD6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_306381</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX87789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87789"/>
    <dbReference type="EnsemblMetazoa" id="EFX87789">
        <property type="protein sequence ID" value="EFX87789"/>
        <property type="gene ID" value="DAPPUDRAFT_306381"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306381"/>
    <dbReference type="eggNOG" id="KOG0263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005884_3_0_1"/>
    <dbReference type="InParanoid" id="E9FYD6"/>
    <dbReference type="OMA" id="GSINEMC"/>
    <dbReference type="OrthoDB" id="620721at2759"/>
    <dbReference type="PhylomeDB" id="E9FYD6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037783">
        <property type="entry name" value="Taf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="PTHR19879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="249"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="333"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="375"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX87789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="455" mass="49727" checksum="C7ADBC5539587B72" modified="2011-04-05" version="1">MNVSGNMIGARGFYTRNQSNFLKVPELRKMAEKFCSENNSHFILELSSESFEVLHSYIGSNDHPLLQQLLNTTLEVNIIKSKIDTSNANQANPKTIVDSSNMEEVHGLLAAISRLKEVPPTAPLLKLYSIDTGQRKMSAASASPCENYLSCGFQDSSVAIWDVKKLRSPSKSDLTRLDLSEACAISIYHPATSAPLPTESDSSVSVCLGHSGPVYATQFTPTNSHVLSCSDDTTLRLWEISSMENVFVYRGHTYPVWDVNISQNGQFFASASQDRTAKIWMFDRTYPLRILAGHTADVDCVTFHPNGLYLATGSADSCVRMWNVAEGKTVRILVGHCGTVLSIAFSPCGTLLASAGEDHRVIVWDVAAGRILHDYTGHQYVVHGLVWISEHVLCSYSADGNIRVWNVAHPSTSSVTPASQLQQQELASYQVASPAKIVHLGRGSRDSLVCIAASD</sequence>
</entry>
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    <accession>E9FZE5</accession>
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        </submittedName>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX87038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX87038"/>
        <property type="gene ID" value="DAPPUDRAFT_235918"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX87038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="61" mass="6865" checksum="E74B0AEE8008EE87" modified="2011-04-05" version="1">MVIPKPLLYWTRSAPGGESKTTTQWDGNESQLEVAKKKFPKPPQLEASIIVGKRWPSKKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9G012</accession>
    <name>E9G012_DAPPU</name>
    <protein>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87146">
        <property type="protein sequence ID" value="EFX87146"/>
        <property type="gene ID" value="DAPPUDRAFT_236120"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_236120"/>
    <dbReference type="HOGENOM" id="CLU_2374916_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX87146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="95" mass="10818" checksum="B1858661533E6BB7" modified="2011-04-05" version="1">MPPRENNLTPCRVTHPAENNPLKKPQKVAEILNRSSFDVIGISRNNISETALSPRVYVHIRINLNGINHEKIMEEKKRRVATSADDRYAAPTWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9G0H4</accession>
    <name>E9G0H4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX86903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86903">
        <property type="protein sequence ID" value="EFX86903"/>
        <property type="gene ID" value="DAPPUDRAFT_312329"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312329"/>
    <dbReference type="HOGENOM" id="CLU_2608465_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237016" evidence="1">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX86903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="79" mass="8871" checksum="C48999729D4362D5" modified="2011-04-05" version="1">MVKAFSKALLYYVLPIFCFIVSGLSQSPLRQDSNHAITGSEKFNTALFPSIADQLKKLSHIRNPRQIDSGKLYMDHSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9G0X7</accession>
    <name>E9G0X7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
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    <organism evidence="2">
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        <name type="common">Water flea</name>
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        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87324">
        <property type="protein sequence ID" value="EFX87324"/>
        <property type="gene ID" value="DAPPUDRAFT_97190"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_97190"/>
    <dbReference type="HOGENOM" id="CLU_390920_0_0_1"/>
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        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3G9</accession>
    <name>E9G3G9_DAPPU</name>
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        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_313559</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    <sequence length="2858" mass="315634" checksum="6C9327A74F800DEB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3H7</accession>
    <name>E9G3H7_DAPPU</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Daphnia pulex</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
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        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
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        <property type="entry name" value="Non-specific_endonuclease"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
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    </feature>
    <feature type="domain" description="Endonuclease_NS" evidence="4">
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    </feature>
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    </evidence>
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        </source>
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        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="EnsemblMetazoa" id="EFX86073">
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_313380"/>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Basu M.K."/>
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                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
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                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="51" mass="5959" checksum="A13AFF36D6F13E66" modified="2011-04-05" version="1">MGRTFLTLSRVQQFSVNDDNLLNQEAEYMMLRYLEDEDAVEIRSMEAGKSL</sequence>
</entry>
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    <accession>E9G8X2</accession>
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            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="92" mass="9540" checksum="F1F5DE5BD1CEA222" modified="2011-04-05" version="1">MKSTSLPLVFLVVLLAVSLPGSTADPVGTCPAVDGAIPVYLPDSVSCEVFYECSNGLATGNICPPNPSGVGNLHWNKSINVCDYPENAKCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Krijgsveld J."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX83395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX83395"/>
        <property type="gene ID" value="DAPPUDRAFT_301973"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301973"/>
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    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="163" mass="18872" checksum="17B9C8120FD88CD1" modified="2011-04-05" version="1">MSKQYKRKKKAKEQIVNFPHSTGVVQAVCTRNNGEKVRQSCGGYRSRDIRCFLRTTLPVGKRDVMDLLRHSRLVAFLFVSIISFQIHEANAVPMVSYRVGNQLRLSPVLVPVSSTVMPVDLMKTKHRSYDERLTPTLANQPKAEFRKSKREKTESFFWPLKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9GE97</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="4">GON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="6">
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        <name type="common">Water flea</name>
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        <lineage>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Thomas W.K."/>
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                <person name="Carmel L."/>
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                <person name="Detter J.C."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
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            <dbReference type="Rhea" id="RHEA:43485"/>
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    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:17815"/>
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            <dbReference type="ChEBI" id="CHEBI:203600"/>
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        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33180"/>
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    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
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        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
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    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="12"/>
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    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_317364"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="PTHR10336:SF31"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7 12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
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    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="16">
        <location>
            <begin position="479"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="595"/>
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        </location>
    </feature>
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            <end position="386"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
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            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
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            <begin position="454"/>
            <end position="472"/>
        </location>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9GFW9</accession>
    <name>E9GFW9_DAPPU</name>
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        <recommendedName>
            <fullName evidence="7">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_242115</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
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        <property type="project" value="GO_Central"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="287" mass="32421" checksum="C02C43307A0049FB" modified="2011-04-05" version="1">MDFSNVNFPFPLWIVRPTWECALKIGFFVPVIIISLLGNGLVVYLMATNRFLRTSINIFIWNLAIADLLTILLIPWIILIIDLYQMFILGEVICRTEGFLRVMLMLIDVFSLLAVSFDRFFAIAFPFRPRMGQSAAYIICGVIWILSAAIASPLIAARVYKMKSRTSTCSAIQLKQLAQRQKIIRMLFFILIGFFICYLPFTISIIVRNKIVLGNSINSIPDWLRALLYTSRYVMCVNTAINPIIYGFCNDNFKKAAAKQFPSLKWGVTPVAATISAASNTGRANSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GFX5</accession>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX81735.1"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="96" mass="10516" checksum="42D890A746759F14" modified="2011-04-05" version="1">MKKFAAGDFMIYVVMWYCFLVNVIGIRGVDIIQDGLVAWSLVLEYLVGGVIGEVVIGYICMWDGGFNSVGLGSVEVSIFDPLLYVRGMDVGVLKDV</sequence>
</entry>
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    <accession>E9GFX7</accession>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX81734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="3"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX81734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="81" mass="9608" checksum="B3B1029DFFD0892D" modified="2011-04-05" version="1" fragment="single">KGYQCEVCQRPFARSDMLTRHMRLHTGLKPYTCRICGQVFSRSDHLSTHQRTHTGEKPYRCPQCSYAACRRDMITRHLRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9GGP7</accession>
    <name>E9GGP7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger protein 830</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Coiled-coil domain-containing protein 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DAPPUDRAFT_50175</name>
    </gene>
    <organism evidence="17">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <accession>E9GHY8</accession>
    <name>E9GHY8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
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            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="50" mass="5533" checksum="EA76BE80B6E5C7D0" modified="2011-04-05" version="1">MSDDDDNRLLSVFALHQREGVDEFKPILLRAKTASPSSNVADDPTMTTRA</sequence>
</entry>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein 1</fullName>
        </alternativeName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Diplostraca</taxon>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the NATD1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX80448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX80448">
        <property type="protein sequence ID" value="EFX80448"/>
        <property type="gene ID" value="DAPPUDRAFT_318643"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S2NM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
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        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
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        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyltransf_CG"/>
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    </dbReference>
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        <location>
            <begin position="17"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006233"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="110" mass="12870" checksum="4DFA3EEEA69CAD9A" modified="2011-04-05" version="1">MNCSSHREFVMEELEVHHDHENSKFCIKLDDENEAVLVYEKKQGMIDMYHTEVPMGYTGRGIAGLLAKAAFDHAVEKEMKMKLSCTYLHNYLHNSLKDDTKEKYLKFVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKY5</accession>
    <name>E9GKY5_DAPPU</name>
    <protein>
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            <fullName evidence="3">Nocturnin</fullName>
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    <gene>
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        <lineage>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX79760">
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        <property type="gene ID" value="DAPPUDRAFT_3216"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG0620">
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    <dbReference type="OMA" id="PTGECCS"/>
    <dbReference type="OrthoDB" id="1387401at2759"/>
    <dbReference type="PhylomeDB" id="E9GKY5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="4"/>
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    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023807"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX79760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="288" mass="33006" checksum="EB986334AA2F618C" modified="2011-04-05" version="1" fragment="single">IRLLQWNILSQSLGEHNDNFVRCPLEALDWRTRRYRIVEEIVEYNPDIICLQEVDHYQFLSRALRSQGYEGIYFPKPDSPCIYIKGNNGPDGCAIFYRANDYELIKVETRIVEVWRVQSNQVVILTMLRHKASGREICVATTHLKARQGALLSTLRNEQGKDILDFLQNNVDVADCPIIMAGDFNAEPTEPVYSTIRSDSRFGFDSAYRCDVDGAEEAGQEPPYTTWKVRGEGESCHTIDYVFFSRRQLGVNQVLPFPTGEQIGPDRVPSFQYPSDHFSLVVDFDLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="17" xmlns="http://uniprot.org/uniprot">
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    <name>E9GL51_DAPPU</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX79853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79853">
        <property type="protein sequence ID" value="EFX79853"/>
        <property type="gene ID" value="DAPPUDRAFT_244524"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_244524"/>
    <dbReference type="HOGENOM" id="CLU_1012858_0_0_1"/>
    <dbReference type="InParanoid" id="E9GL51"/>
    <dbReference type="OrthoDB" id="14616at6657"/>
    <dbReference type="PhylomeDB" id="E9GL51"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX79853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="287" mass="32774" checksum="EFCF27FE87237AFC" modified="2011-04-05" version="1">MDEQLQCTVTKCILRRITSTQSVDFDVVMLLFAVSLKAGSITGVTMFPGYGGCQSTTPPPCYTTTTFAPTGYYTEAHNYYTTKASEYYTAANAAPSYIIKLLHHQVTGVLHVCCPSLYTEAPKNYSVPSYYTEAPTYYTTKAAEYYTEPPKYYTNKAPEYYTTTCASSTHYTEAPKYYSAPSYTTRTEAAKYYVVPAIYTADTPSYYVEPEYYTEAPLLHHNLRYPYYTLYRGPYAPEYYNTTYAAPTNYTEASKYYSIPSYYTTKAPEYYTTPHASPTYYRDVSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9GL57</accession>
    <name>E9GL57_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centrosomal protein of 19 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_52097</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CEP19 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732550">
        <property type="protein sequence ID" value="EFX79849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79849"/>
    <dbReference type="EnsemblMetazoa" id="EFX79849">
        <property type="protein sequence ID" value="EFX79849"/>
        <property type="gene ID" value="DAPPUDRAFT_52097"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_52097"/>
    <dbReference type="eggNOG" id="ENOG502RZP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113348_0_0_1"/>
    <dbReference type="InParanoid" id="E9GL57"/>
    <dbReference type="OMA" id="GWDSESA"/>
    <dbReference type="OrthoDB" id="1594443at2759"/>
    <dbReference type="PhylomeDB" id="E9GL57"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034454">
        <property type="term" value="P:microtubule anchoring at centrosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097712">
        <property type="term" value="P:vesicle targeting, trans-Golgi to periciliary membrane compartment"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029412">
        <property type="entry name" value="CEP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31539">
        <property type="entry name" value="PTHR31539"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14933">
        <property type="entry name" value="CEP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX79849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="169" mass="19492" checksum="E327D2221523E308" modified="2011-04-05" version="1">MASPPHQWAGKTSRVIRARKIGLKLDPLSLILLYQDGEVKVRKRFMPIRNLKSQADPWARAEELKLRHMTYLAAVPTVILTKLISIAQQVMIGLDVDEAVRQVTQRFSVDVERDLNVVSEPELKRQKELMELTFISNVIGPSDPRFVYDKQVAFHRPDRVSDWDEDNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPN7</accession>
    <name>E9GPN7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_320370</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732557">
        <property type="protein sequence ID" value="EFX78414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78414">
        <property type="protein sequence ID" value="EFX78414"/>
        <property type="gene ID" value="DAPPUDRAFT_320370"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_320370"/>
    <dbReference type="HOGENOM" id="CLU_1769941_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GPN7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX78414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="147" mass="16830" checksum="A0FCFBA8C954C5F6" modified="2011-04-05" version="1">MEQPHRINGQVHHSLLEICQTNVKKPSTTRTTAPITKPNGHQTTDPSEKSKILLEQFCPTEREDRKDDRTKLYEQTIQDAMQNKESHPLNTPISITELEINLTGLPNKAMGRDRIHNEMLKNLNQNNRTTLLKPLNISLNTGYLPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPV2</accession>
    <name>E9GPV2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotran_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_105238</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732557">
        <property type="protein sequence ID" value="EFX78445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78445"/>
    <dbReference type="EnsemblMetazoa" id="EFX78445">
        <property type="protein sequence ID" value="EFX78445"/>
        <property type="gene ID" value="DAPPUDRAFT_105238"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_105238"/>
    <dbReference type="eggNOG" id="KOG2840">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_1273672_0_0_1"/>
    <dbReference type="InParanoid" id="E9GPV2"/>
    <dbReference type="OMA" id="CIENYIM"/>
    <dbReference type="OrthoDB" id="697150at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Detter J.C."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Robertson H.M."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Manak J.R."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
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        <source>
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        </source>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
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    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
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    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTEN_C2"/>
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    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
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    </dbReference>
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    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
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        <location>
            <begin position="9"/>
            <end position="281"/>
        </location>
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        </location>
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            <begin position="446"/>
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        <source>
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        <source>
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            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1214" mass="132892" checksum="93B3799FCB24115E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9GW55</accession>
    <name>E9GW55_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_249214</name>
        <name evidence="3" type="ORF">DAPPUDRAFT_249218</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <end position="60"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX76325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="381" mass="42810" checksum="A74CBFCFE0681A31" modified="2011-04-05" version="1">MEDLFIHRRNGPIPSNVNLQKERPVCLSFQLEGHGDTYTHPQRRQPAKGKARPIPSDVNLPKERPVNYNVVLLSDVVSLMAGSTTSVSMSLWARIPNRNAAALLHNSNIRNLGALNCTAPPGLQSITPKLVMPRATTLIPEASEYYTTTYAAAPAYYTEAHYYNNTEVTKYYTTTCAALSYYKDASNKLYRRWGCIVDGWVDHSTGESTTKLPECYTKTYAAPKYLTDAPKCYSAPSYYTSKAPTYDDPSHITTPRLPSATLFPVNKSRLRLITPTKRSNTTPKCQITALPRSTQPQPAKYYAAPTYYSEELAMAPCSFWLMVGSTTANYNNAPMCYSVPSYYTEDLTCCTTEVPKYCTTTYVTPEYYTTKAPEYYVELEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GWI1</accession>
    <name>E9GWI1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_322604</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX76107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX76107"/>
        <property type="gene ID" value="DAPPUDRAFT_322604"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_322604"/>
    <dbReference type="HOGENOM" id="CLU_3016316_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="56" mass="6482" checksum="4D49411485B83BC2" modified="2011-04-05" version="1">MAWYANNKYTEEMMKVMRTKGFKRTMMGVVIGSVAGLMVINYNNKRLGHSEATKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Ye Y."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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    </evidence>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Basu M.K."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Manak J.R."/>
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                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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    <sequence length="336" mass="37806" checksum="1885B4B4E5FD425C" modified="2011-04-05" version="1">MTIVSGHLEPEFVDAVQNITVPVGRDVKFSCHVRHLGTSYKVAWIHFERSAILTVYNQVITRNPRVGVSHENHRTWHLHLNDVQEADRGRYLCQINTAQAKTQSAYLNIVVPPTIEDSASSSDVIVREGSDLSLTCQARGSPTPSVKWRREDGRKISTNKSFSSTEVEGSSLELQKISRLDMGVYLCIASNGVPPTVSKRIYVSVDFPPMVWVPQQLVGSPLGATVTIECWLEAHPAALHYWARPDGQVLHDPTKYRIESINGVTAYMTHLKLTIRHLTVRDYGPYRCVAKNPRGETDGTIKIYRELISLTFRSLPLSAHLKLKTDREKEMETDAH</sequence>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
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    </reference>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX73118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="335" mass="37986" checksum="08119BC18082A753" modified="2011-04-05" version="1">MEKNKKRDPRYIKSRAVKNSAKKAAAAAVLKRQQLKEAKEREAGNKVPSIDTDTGHEAQNNVEESVASEEPVEEPGQELEPEREPVLDQGPADEEEPIAEKERETANEEPPVKAKTVVNLKKVTVRLERLAFNPNDDEKQERKNLWSLLEFKRIVTTSLLFYGLNAEKARKEDAPEARLMKEIPLSAEPGAKRRKDRLSVPDEIRFSQVGIHHPIFVENRGRCEWCQATTERRPNGHTKESRPFSQCSMCKIFLCLSKKRNCFLEFHDDRILDPTKAAAETVLAVDPEEEIAVQTVETDPLGIYPSSDSSDDSDFDALNNDVNDGVLLDEDEWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9H7J0</accession>
    <name>E9H7J0_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DAPPUDRAFT_326374</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732601">
        <property type="protein sequence ID" value="EFX72195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72195">
        <property type="protein sequence ID" value="EFX72195"/>
        <property type="gene ID" value="DAPPUDRAFT_326374"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326374"/>
    <dbReference type="HOGENOM" id="CLU_3052470_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX72195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="54" mass="6142" checksum="1E27F47C9603FE1C" modified="2011-04-05" version="1">MVPKPGSNINIDYPKGTLENTRVPLTNEPLTNVISLTSKFLHYSILYQIVRELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9H944</accession>
    <name>E9H944_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_308735</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the akirin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732607">
        <property type="protein sequence ID" value="EFX71723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71723"/>
    <dbReference type="EnsemblMetazoa" id="EFX71723">
        <property type="protein sequence ID" value="EFX71723"/>
        <property type="gene ID" value="DAPPUDRAFT_308735"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_308735"/>
    <dbReference type="eggNOG" id="KOG4330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119227_0_0_1"/>
    <dbReference type="InParanoid" id="E9H944"/>
    <dbReference type="OMA" id="RRCAPIM"/>
    <dbReference type="OrthoDB" id="1420469at2759"/>
    <dbReference type="PhylomeDB" id="E9H944"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045089">
        <property type="term" value="P:positive regulation of innate immune response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024132">
        <property type="entry name" value="Akirin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293">
        <property type="entry name" value="PTHR13293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX71723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="198" mass="22514" checksum="D77F0D123C29A7BD" modified="2011-04-05" version="1">MACVTLKRSLEFDPVHSPGGRTPKRRRCMPICMPPTTPPTKCHEPSPFGDVSSKLTPEQILANVREEVKRFQRRKQLNFSQNQSQHMSSQHQDSLMCESPTSPASPASCPRSPSPLMALASSNNFGQSCSTKEKPLFTFKQVSLICERMLKERETEIREEYDRVLTLKLAEQYDAFVKFTQDQLQKRFEANAAPSYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9H970</accession>
    <name>E9H970_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_326927</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732607">
        <property type="protein sequence ID" value="EFX71743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71743">
        <property type="protein sequence ID" value="EFX71743"/>
        <property type="gene ID" value="DAPPUDRAFT_326927"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326927"/>
    <dbReference type="HOGENOM" id="CLU_1108051_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9H970"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX71743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="251" mass="29324" checksum="62D2FA971F1272D2" modified="2011-04-05" version="1">MDIVIKEEIGVGETGRRIERIAFNVIPYFDVLKNIERRNVARTSHFSAFFSLQYTALFKFLTMGNSKSTPKSDIMSDEELMKIPKFSDTYNKQNLFAFLTKYVSTLFTITFQKEIGQYRAVLTVCGEEEPTDFFKRLRVDAERYSFKPGQNFLEYKRRISTGLKEFGNYHPQVVVREMETIFPDLSCNIYPKTKARSYTCVLHVRPFGVVYEEEERGSRKMEAKIGAYMKMAKRLFRIGYIPPYSPGNVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9D0</accession>
    <name>E9H9D0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_189107</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732614">
        <property type="protein sequence ID" value="EFX70995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70995"/>
    <dbReference type="EnsemblMetazoa" id="EFX70995">
        <property type="protein sequence ID" value="EFX70995"/>
        <property type="gene ID" value="DAPPUDRAFT_60693"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_60693"/>
    <dbReference type="eggNOG" id="KOG2548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064585_0_0_1"/>
    <dbReference type="InParanoid" id="E9HB58"/>
    <dbReference type="OMA" id="WRGLLPF"/>
    <dbReference type="OrthoDB" id="1620115at2759"/>
    <dbReference type="PhylomeDB" id="E9HB58"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040397">
        <property type="entry name" value="SWAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019147">
        <property type="entry name" value="SWAP_N_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161">
        <property type="entry name" value="PTHR13161"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DRY_EERY" evidence="2">
        <location>
            <begin position="24"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX70995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="322" mass="36830" checksum="B135CBD49EDE3C48" modified="2011-04-05" version="1" fragment="single">MVDHRRRAERRREYYEKTKGDPAQFLQVHGRPMKIHVDPAIAAIADSPATMMPWQGQPEILIDRFDVRAHLDVIPCRPQKDDSDTDQDPGEEVWEERQASYERYRILVQNEFIGVSEEKFLHQILLEEQFGPVQKLGEEEKKKMLAPKKAAIGFTYDDSTPSSSAAASTSHNIPVVPPEATEEEESDSDIDLDLSIAVDKLTTEQMHEVNKCALHYGLGRQDFMSLLTRDLDEQESLRIAKEEEQERAMYSGRKARKERRAFREQKLQALLMNRCLSPPSYATRASPTYDGQLRRSKSVSKSRSPSPFEGGIKFITSFGDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HB87</accession>
    <name>E9HB87_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_256362</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732615">
        <property type="protein sequence ID" value="EFX70994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70994">
        <property type="protein sequence ID" value="EFX70994"/>
        <property type="gene ID" value="DAPPUDRAFT_256362"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_256362"/>
    <dbReference type="HOGENOM" id="CLU_940943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="296" mass="32857" checksum="7218AD666E66293F" modified="2011-04-05" version="1">MIEFRHRNHFNHPLAVSYSTPYVSSGYSSYDWGSAAPSTSQHAVDPHPTTSFFGEMNSNFGNNLTNAAECSGDPGSSHPSTMLDLTNSSRQNTLIPMREPNFQANNGQRKTPNFGNNSQQYTDELNAAECSGDPGSSHPSTMLDLTNSSRHTLITMREPNFQANNGQRKTPTIEYYNHASGDMIPFASGSMEKGKSLLSPGSTENLNSQSSIKDIHFKSTSFSSNEENVPSKFPICMDIAKTIYNRVGRKMSLFTSKLMDYLFSASYLMDHRLTDNMMNSDKKVADKEQISQLIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9HBP3</accession>
    <name>E9HBP3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_60800</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallophosphoesterase superfamily. MPPE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732616">
        <property type="protein sequence ID" value="EFX70884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70884"/>
    <dbReference type="EnsemblMetazoa" id="EFX70884">
        <property type="protein sequence ID" value="EFX70884"/>
        <property type="gene ID" value="DAPPUDRAFT_60800"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_60800"/>
    <dbReference type="eggNOG" id="KOG3662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047168_2_0_1"/>
    <dbReference type="InParanoid" id="E9HBP3"/>
    <dbReference type="OMA" id="SRTLHCM"/>
    <dbReference type="OrthoDB" id="1094620at2759"/>
    <dbReference type="PhylomeDB" id="E9HBP3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="PTHR13315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="6">
        <location>
            <begin position="71"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX70884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="370" mass="43095" checksum="96F7DB10285EEC85" modified="2011-04-05" version="1">MGIFNAESPIVKLSQHVENNIPKQKMNRYIFLITFFICLVFFFCEYLIYFIVQFQCDWPALSQNNQSHQLRALILADTHLLGPYRGHWFDKLRREWQMSVSWSAAITLHSPKAVFFLGDIFDEGKWANQNQYEDYVERFTQLFPSNSPHYVLVGNHDVGFHYMMDAIKLNRFYQTFNLSSSDIFRVGGIPFVTVNSMAMEGDGCHICKEAEKRITSIASGLKANEKPVLLQHFPLFRKSDESCQGEDSAPDEEKVVNFRPKFDCLSKTSSNWLLRNLKPRVVFSGHTHHSCVYNHSGVTEFSVPSFSWRNRNNPSYLLVIISTDEYAVYKCFMPKESTVIRIYVIFVIVLMISSIFFGYKRFRARHVKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9HBS6</accession>
    <name>E9HBS6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_112349</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Tang H."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="48"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="221" mass="23541" checksum="48E641B7C6B614AB" modified="2011-04-05" version="1">MVVQRRQAKAAGRGRNVEPVTPSLTGRGRAATDEVSDRLRSELLQASRAELPPSSSSGSSESYISSTSPVSRPATPNEDTGATFVPPDQNAQRLGSPDLPTPNLNGISTDFPQPLMDKVKEKVSKVNAILREQSQSITMLTGAMPAIQEGVANLRTAIQNDVASKLRATEETFGRALAVLRRESNTALATTAAEPREATTVITAQLAQLFKALTQTSESRS</sequence>
</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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    </evidence>
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</entry>
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                <person name="Basu M.K."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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    </evidence>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
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                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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    </evidence>
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        </source>
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</entry>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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                <person name="Thomas W.K."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="SecA_X-link_sf"/>
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        <location>
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    </evidence>
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</entry>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732624">
        <property type="protein sequence ID" value="EFX70209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70209"/>
    <dbReference type="EnsemblMetazoa" id="EFX70209">
        <property type="protein sequence ID" value="EFX70209"/>
        <property type="gene ID" value="DAPPUDRAFT_228440"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_228440"/>
    <dbReference type="eggNOG" id="KOG2780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040063_1_0_1"/>
    <dbReference type="InParanoid" id="E9HDH9"/>
    <dbReference type="OMA" id="WIISNKR"/>
    <dbReference type="OrthoDB" id="768872at2759"/>
    <dbReference type="PhylomeDB" id="E9HDH9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="PTHR22734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="125"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX70209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="336" mass="39828" checksum="122FDC55246E25B8" modified="2011-04-05" version="1">MENAEENEAGEVLVKPKILTASERLAAKKRFRTQRRLSTMKNKVLRNAQWATLKKEKRKIKKEGQKQRKKEAEALGDKAPPKQVPRTIENTREADVTTVDQEDEEVTFDITHDEYEAYFSKTYEPKILITSSDNPHSKTIHFIRELTKIFPKSECQWRKRSSVKKMIESAKEKDYTDVVVINEDRRVPNGMLVSHLPDGPTAYFKISNVKLTKDMKYKNIIKEFTTHRPEVILNNFQTRLGQAVSRMLASLFHYDPQFKGRRAVTFHNQRDYIFFRHHRYEFKSQKRAALRELGPRFTLRLKWLQKGTFDTIEGDYEWIIAGKRHEMETSRRRFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDJ9</accession>
    <name>E9HDJ9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GMP_PDE_delta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_231640</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDE6D/unc-119 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732624">
        <property type="protein sequence ID" value="EFX70156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70156"/>
    <dbReference type="EnsemblMetazoa" id="EFX70156">
        <property type="protein sequence ID" value="EFX70156"/>
        <property type="gene ID" value="DAPPUDRAFT_231640"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_231640"/>
    <dbReference type="eggNOG" id="KOG4037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088825_2_0_1"/>
    <dbReference type="InParanoid" id="E9HDJ9"/>
    <dbReference type="OMA" id="CNSADMG"/>
    <dbReference type="OrthoDB" id="1270912at2759"/>
    <dbReference type="PhylomeDB" id="E9HDJ9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008015">
        <property type="entry name" value="PDED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037036">
        <property type="entry name" value="PDED_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032977">
        <property type="entry name" value="UNC119_homologue_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12951:SF5">
        <property type="entry name" value="PTHR12951:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05351">
        <property type="entry name" value="GMP_PDE_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMP_PDE_delta" evidence="4">
        <location>
            <begin position="71"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX70156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="246" mass="27916" checksum="BF2D514C958D40AD" modified="2011-04-05" version="1">MSTLHGSVGSHTSVGLPTSSDSSDLPSAISTSDKKQEHSEPISDSPIARNITPEDVLKLKQITNSYLCAPDANIYDIDFTRFCIRDLESGTVLFEIAKPLPPELCDNPPETDVNDLDPNAGRFVRYQFTPHFLKLRTVGATVEFVVGEKPVNNFRMIERHFFRDRLLKTFDFEFGFCIPHSKNTVEHIYDFPALSSEAMDEMINHPFETRSDSFYFVENRLIMHNKADYAYNGGTIQNNTHNEDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDY2</accession>
    <name>E9HDY2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_328521</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732626">
        <property type="protein sequence ID" value="EFX70053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70053">
        <property type="protein sequence ID" value="EFX70053"/>
        <property type="gene ID" value="DAPPUDRAFT_328521"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_328521"/>
    <dbReference type="HOGENOM" id="CLU_889224_0_0_1"/>
    <dbReference type="InParanoid" id="E9HDY2"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="PhylomeDB" id="E9HDY2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="151"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="313" mass="35419" checksum="101E78392561224D" modified="2011-04-05" version="1">MQKSLQSSQSAVGQHVLELCKQVKQDEERYNVSPDKLDANDIKKAKAVSVLAFLAELPLATINSLSKTDLISRLSLEYEVSRLSDDLDIQADQIKFLEEKISPNEIVAIFVKDSDLDSLKKELNFWHLANQHISNFPGCVELTTTTCPLCLSYVYLRPSIYNFSTTITPILEAIAAPFTIIDTDANAKFQLWNSMLSDKRGSEFEPMLAYFILNVVNRSKTELDFSPSGTCFVDLTLVGDKVRVHRWLYLATPSISDHPYIFFEIDHVHFAKSQMKPNCWLAPNLSRVNRDLFSRKLFYALSNLPTPRGSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HF89</accession>
    <name>E9HF89_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_113526</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX69603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX69603"/>
        <property type="gene ID" value="DAPPUDRAFT_113526"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_113526"/>
    <dbReference type="HOGENOM" id="CLU_1385437_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX69603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="197" mass="21498" checksum="80A4D22B23BED00B" modified="2011-04-05" version="1">MRVIAGASTFNALFSSRGNGIQTAGLRGSFIDESDDIINRQSSPGAQRLRVGITHEKRRPVVHQQTLHSAGTEDVGCFVASSKKGALKLPPWCRQSAEIASGCLARSQQLFSLKNRLSRHQKPIKSTLTFHKDIEINGKLPPSPNSLSLPAGLPPSSNFIVDPGSARAKFDTLRPQRFVEVEEAAKTIIVLLYKQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HHE3</accession>
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        <submittedName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_114210</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732647">
        <property type="protein sequence ID" value="EFX68860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68860">
        <property type="protein sequence ID" value="EFX68860"/>
        <property type="gene ID" value="DAPPUDRAFT_114210"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_114210"/>
    <dbReference type="HOGENOM" id="CLU_567742_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HHE3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="397" mass="42865" checksum="4E4D5E28096802E2" modified="2011-04-05" version="1">MGRRRRESEVSTSSESSTSSSSTDTSDASSTDSYVTSRRKKGSNRDTSPDRIQKNPSNPKASGSGDAAAASVALTNLIRATLGGAGEEVPAQEADGDAGGIEAPAHAGAAANGVAAADGVAEERPIPAVGQALLRLASFIEAQHAPKSSRKKILKPSIKQSRRMLKRLRRGASNKRVGQLKSKYRLDVEDSMDFKVPSIDFEMHLKLQKLLGQSTGKGVNEVEKTLYKVQQSMLPVFSVLAFLESKALEGDAGKAVRHLAELIGRSYFDVSDLRRRNILEIVGPAIIPLLEDRDIFEVSEGKDLFGSSVMKRLSKSGRFVRELVDLDVGGQRKGKLPVRERLSLTPSCDQQSSYKVQPTNHSQDDNDHPVTTALSEEEDGDIVVEATKSQIAISWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJF2</accession>
    <name>E9HJF2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name type="common">Water flea</name>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732662">
        <property type="protein sequence ID" value="EFX68073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68073">
        <property type="protein sequence ID" value="EFX68073"/>
        <property type="gene ID" value="DAPPUDRAFT_330383"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330383"/>
    <dbReference type="HOGENOM" id="CLU_2471319_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HJF2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX68073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="88" mass="9816" checksum="1B16F14795377C83" modified="2011-04-05" version="1">MAASVPAGRIKQDSDMETIRYLLEDGQDISAMTWGEDETNALHVAAANECNDAGSHRHHSRNWENSEGYLFITQLKDPTLLQSIMLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKL1</accession>
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        <submittedName>
            <fullName evidence="4">EOG090X0CTI</fullName>
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    <gene>
        <name evidence="4" type="primary">EOG090X0CTI</name>
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    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Diplostraca</taxon>
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    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CH-H</strain>
            <strain evidence="5">TCO</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL732669">
        <property type="protein sequence ID" value="EFX67736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR014269">
        <property type="protein sequence ID" value="SVE83888.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015494">
        <property type="protein sequence ID" value="SVE85113.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67736"/>
    <dbReference type="EnsemblMetazoa" id="EFX67736">
        <property type="protein sequence ID" value="EFX67736"/>
        <property type="gene ID" value="DAPPUDRAFT_93654"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_93654"/>
    <dbReference type="eggNOG" id="KOG2659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073203_1_0_1"/>
    <dbReference type="OMA" id="QNGRIQE"/>
    <dbReference type="OrthoDB" id="1365635at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CLTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LisH" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="64"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX67736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SVE83888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SVE85113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="230" mass="26482" checksum="B87B9D7FBA6CC540" modified="2011-04-05" version="1">MTAFTDKPSEIGKQEWLEKLENVHLPRTNMNRLVMNYLVTEGFKEAAEKFALEAGFKAPAELERLDERIKIRDAIQAGKIQEATALVNQLHPDLLDSDRYLFFHLQQQHLIELIRQKNIEEALKFAQEHLAERGEQNPAILGELERTLALLAFDDPEKSPFGDLLHTSHRQRVASELNAAILKAEHRESTTPQLVSLMKLVMWSQDQLDQRKVKYPRLTDLARATLDDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9HM48</accession>
    <name>E9HM48_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="3">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_115659</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Golgi apparatus membrane</location>
            <topology evidence="1 3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="3"/>
    <dbReference type="EMBL" id="GL732684">
        <property type="protein sequence ID" value="EFX67203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67203">
        <property type="protein sequence ID" value="EFX67203"/>
        <property type="gene ID" value="DAPPUDRAFT_115659"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_115659"/>
    <dbReference type="eggNOG" id="KOG4651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106861_0_0_1"/>
    <dbReference type="InParanoid" id="E9HM48"/>
    <dbReference type="OMA" id="STIHRED"/>
    <dbReference type="OrthoDB" id="1330889at2759"/>
    <dbReference type="PhylomeDB" id="E9HM48"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="PTHR12137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX67203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="208" mass="24564" checksum="BE68E53B9E87CE6A" modified="2011-04-05" version="1">MKKGNRQISQVARQQFPSIDYPAAAELMKEAKKWMVVRHPFERILSAYRDKLENSTIHREDGTLHFYEKYGRKIVAKYRGKFPKEQNGGERIEPTFQEFVAYLINTDLTLYADDHWIPYYLFCTPCLIDYDVIIQFETLQEDVQLLLNLLGESSGPLRKHSTTLGRSKTELIKSYYSRLDRETILKLYEKYKIDFELFGYSIDGYLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9HMV4</accession>
    <name>E9HMV4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_331582</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732690">
        <property type="protein sequence ID" value="EFX66942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66942">
        <property type="protein sequence ID" value="EFX66942"/>
        <property type="gene ID" value="DAPPUDRAFT_331582"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_331582"/>
    <dbReference type="HOGENOM" id="CLU_1504955_0_0_1"/>
    <dbReference type="OrthoDB" id="223749at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="5">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX66942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="179" mass="20106" checksum="6A6BB5FC680FE613" modified="2011-04-05" version="1">MASVSSGGSLPDDNFSNDSIDFVLQDVQTENDADDFRSLMDEIGIVEGDHDEPNENLKSKVWQYFTTDRTSRSKATCKLCEKLIDRSGGSTTNMIRHLRNVHKKEPGCASGKKSSGQKRQQRVSTKENLRLDRLFAMLIIYYSNQLMKAAAFGNLTSSDYPCFGRSCKCHACFNDLKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPG6</accession>
    <name>E9HPG6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_116463</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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        <source>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX64151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="153" mass="16864" checksum="0CBEEC9AC9B8E9B3" modified="2011-04-05" version="1">MLVMLDKATSHITVPVPNKRNARNETALHLVCKPSLNVPPSAQDRRLACAHLILQWKGGFSAVSGNIEQADLKALDMHGNIVLHLSAGSGLDRVVELLVSHGAPLFLENSERLTPCDVAMRANFHDITLFLESRMVFAITMKQCTKLMKNKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9HX48</accession>
    <name>E9HX48_DAPPU</name>
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        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732997">
        <property type="protein sequence ID" value="EFX63682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63682">
        <property type="protein sequence ID" value="EFX63682"/>
        <property type="gene ID" value="DAPPUDRAFT_335152"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_335152"/>
    <dbReference type="eggNOG" id="ENOG502RZEF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1166872_0_0_1"/>
    <dbReference type="InParanoid" id="E9HX48"/>
    <dbReference type="OrthoDB" id="1374327at2759"/>
    <dbReference type="PhylomeDB" id="E9HX48"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
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        <property type="entry name" value="Exo_endo_phos"/>
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    </dbReference>
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        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="5"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="238" mass="26291" checksum="0CFC266495571FAC" modified="2011-04-05" version="1">MKIATINIARISSEERLILLLNYCLTQKFDVVGLQEVAFASCPILENHFQLFAAPGPNKAGTAILVAKHLAVHHSVCDRTDGRLISVQFNNVSFVSLYAPSGRVFRDERSAFFRVIVPAFLSSIKRPLILVGDFNAVDGPQDRIRLAGTKPSTPVDHALVALVASLELVDMWKALRPRDLGHTFTHQGGSARIDRIYCSRSIKNSVTNIRLDSTYVTDHSAILAHCSLLSETSKEERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9HX96</accession>
    <name>E9HX96_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_268091</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX63630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63630">
        <property type="protein sequence ID" value="EFX63630"/>
        <property type="gene ID" value="DAPPUDRAFT_268091"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_268091"/>
    <dbReference type="HOGENOM" id="CLU_1195915_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HX96"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="SSF49562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="87"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX63630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="232" mass="26704" checksum="73A3AD24E429E768" modified="2011-04-05" version="1">MTPDEQMEKNQEEEKEGKEEEEKKEEEIEKEKNEGGEEEVKEEEEKEEEKENEGGEGGEEEEEDEEDEDLLTGNKNPIKVVNTPKLVEMKVVRGVNFPKAKDSDQYYLSVLVEEMRGKFCYQNQTKKFKSKTIRDRWNKNFTIQTQHPESSQITIKVKKSSIFGLKKSTVGFVKMAVSDLMHDENGHVSALKMQLNDESNNPVGEAYLELDMKVGDLPEVVPSPAEPSRNHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9HY63</accession>
    <name>E9HY63_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_335634</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733115">
        <property type="protein sequence ID" value="EFX63319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX63319"/>
    <dbReference type="EnsemblMetazoa" id="EFX63319">
        <property type="protein sequence ID" value="EFX63319"/>
        <property type="gene ID" value="DAPPUDRAFT_335634"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_335634"/>
    <dbReference type="eggNOG" id="KOG1396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_418126_0_0_1"/>
    <dbReference type="InParanoid" id="E9HY63"/>
    <dbReference type="OMA" id="IGMETII"/>
    <dbReference type="OrthoDB" id="1550835at2759"/>
    <dbReference type="PhylomeDB" id="E9HY63"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="PTHR12953"/>
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            <end position="499"/>
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            <end position="21"/>
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        </location>
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            <begin position="627"/>
            <end position="656"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF07738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX63319.1"/>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Daphnia pulex</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <text evidence="2">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.</text>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
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</entry>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
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                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Koonin E.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Robertson H.M."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="231" mass="26441" checksum="7A449949494741DF" modified="2011-04-05" version="1">MKSSKERAGEEEKEEEEKEEDQEEEKDQEKEEDQEKEEEEKKEEEEEEEEEEEEEEEEEEEEEENNKMEKQVKCSTKYTPPSKNAKQYPSPNCHEDVDSLLTLQNERNNLSPLSSAPLSPYSTTSSSPNYQHHEEGEIFGPSNSGIPPQTTLKRVADGTAGTAAASLIKYLVFNKDPKLAVEPCVKVRLLSAPFQTQGKTRRTRRGNGRLPGRLPTRKGPSRKKIIEQKFV</sequence>
</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="106" mass="9852" checksum="42EBB52430721873" modified="2011-04-05" version="1" fragment="single">MLISLGSVEGWQSSVAESAAAAAGSSASSAASQAVTAAVSAVAAVSAAAHQSSIGAAASGGGGSPSGATDVILTAENLTQAVIILILDVVIICSNLLIIATLATGS</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
    <sequence length="345" mass="39394" checksum="2730AE2EA86C95CE" modified="2011-04-05" version="1">MAESVVPALTSIAEEDLEKHHDRYVQCNAPNCSQDDFDGERDWIQAVIYDHQAILAKCDDYLVQTNPKPASTVSRASSRHSSVSSRQARIHETERKEREAQLMLRQVEDETRRREEEDAKIREAEDYKRKVESERKQREIRDEIDLQRLSGAIMRQQLNDVTVNDQAAPTRASSVVSGLSRNANTNETLQPTGSDGCLNTKGDPFRQITSSYHARHTYTFHIRATYTLECRRVECHRYNRYNESDVFHTVVYSSTAGNDESAHVNGFKHRYSANVVLPGSYTDRSAEYDIDKRSNSYVGSSSGPYIDCTIVRPTNFRISRRSGLYISGSSVHAGDYSYHPRPDDQ</sequence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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                <person name="Yamada T."/>
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                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734804">
        <property type="protein sequence ID" value="EFX61304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61304">
        <property type="protein sequence ID" value="EFX61304"/>
        <property type="gene ID" value="DAPPUDRAFT_340206"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_340206"/>
    <dbReference type="HOGENOM" id="CLU_1158860_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="240" mass="25687" checksum="5DB72B8E2443D0B5" modified="2011-04-05" version="1" fragment="single">MQRGKSADPLLDAALAVGEFVNPFILNAVPAGNVFALAHSPSGTSLIDQLSERVTSNVERIGVIGAFFDTELALIAELKKRWPMAEIVVGIDPESLQMPGSPPPGVARYVDARHLWTDNKNYLHAKAIYFEADQDSAFVSGSANPSRPAWISQASNGNVEAVLLRIGQSAIDTATDVGICGLFDLDSVGEEVLKNVKTRTAIERASNEVDPVPLLIGIANHESGNLDITLRADLMSFDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9FQZ6</accession>
    <name>E9FQZ6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_94295</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX90279">
        <property type="protein sequence ID" value="EFX90279"/>
        <property type="gene ID" value="DAPPUDRAFT_94295"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_94295"/>
    <dbReference type="HOGENOM" id="CLU_2252684_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX90279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="104" mass="11592" checksum="530059D1A109EE97" modified="2011-04-05" version="1">MKSKKTVNVKSCLKLVDSVTLWHQVLSDAIINFFFFVFSLPRSSVGRDWAGLGWAERCVQVTLGLKYTRDGRMLIGDRASGRTNPVCHTPFTQSIDAAVWPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9FR00</accession>
    <name>E9FR00_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_309857</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX90278">
        <property type="protein sequence ID" value="EFX90278"/>
        <property type="gene ID" value="DAPPUDRAFT_309857"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309857"/>
    <dbReference type="HOGENOM" id="CLU_1074634_0_0_1"/>
    <dbReference type="OrthoDB" id="1714553at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX90278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="259" mass="29876" checksum="1CDC4B61E4A0BCB9" modified="2011-04-05" version="1">MSENAPCACCLDDRSWTCILLANVVFGVIAGCIAALIVTQTSLITHFKPTPYHPPNTTFTVDYLWQGYRYHFYKTMETYEDAKKICEYHNTSLLVFDSNQEEKELDCYLNARNNAEEQQLSIWINETFLFGGPFMYARPASFFSDSREAVVLKANKIIEENGCDVQDNFEENQALWTEDQQNSEAETTYFIEKLYGNHGLRGPKQGSTNGCWNFVRFNLAKEKKNFFICRSNNPTVQGTTTTTSLSNFQRHQFFSEKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9FR55</accession>
    <name>E9FR55_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_299926</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX90105">
        <property type="protein sequence ID" value="EFX90105"/>
        <property type="gene ID" value="DAPPUDRAFT_299926"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299926"/>
    <dbReference type="HOGENOM" id="CLU_1148194_0_0_1"/>
    <dbReference type="InParanoid" id="E9FR55"/>
    <dbReference type="OrthoDB" id="1565344at2759"/>
    <dbReference type="PhylomeDB" id="E9FR55"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16845">
        <property type="entry name" value="SQAPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="SSF54403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018630181" evidence="1">
        <location>
            <begin position="21"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="2">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="2">
        <location>
            <begin position="130"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX90105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="242" mass="25773" checksum="E6E238911BDA7333" modified="2011-04-05" version="1">MAPFLTTTILLVVAMLTADAARLTKRQIGFVGGFSPAKVDDAEVVKMADFATTAVSANMNSGPVKLLKIVKAETQAVSGTNYKLNLELAGANSEVIPCEVVVFHQPKTNTQKMLRSSCTPKRKTTRQVGVITGGFSPLDVENVTVKEMAAFATTAISANTNSGPVTLVKVVKAQSQVVAGLNYKLTLELNGAEGAILCEVTVFDQSWTNTRKLTESKCFPAKNALVKVAEAVHADTQVKTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRJ0</accession>
    <name>E9FRJ0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein ASH2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ASH2</name>
        <name evidence="3" type="ORF">DAPPUDRAFT_232740</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DAPPUDRAFT_232740"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
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    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="bHLH_dom"/>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015660">
        <property type="entry name" value="MASH1/Ascl1a-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935">
        <property type="entry name" value="PTHR13935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
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    </dbReference>
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        <property type="entry name" value="HLH"/>
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    </dbReference>
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        <property type="entry name" value="BHLH"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="70"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX90189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="224" mass="24092" checksum="596DAF5C66183756" modified="2011-04-05" version="1">MVKPTPTRSIGCSLKSFRRRLPQQNLPVRDTSLPPVSSQQSSPYVNNIPSVSSSAGRVGTKNSLGPDPPASVARRNACECNRIKKVNTGFAVLRQHIIPVLCGSVIVNGGSPHYSEPLSSSSSSPPATSSSSKKNQMSKVETLRCAVEYIRNLEKLMVTSGGSEMEQDQLSTKEKPLDCLPYKLDVAVGSPSMQESRENISTLEIAGLWTSANDLMSGFYDSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRJ4</accession>
    <name>E9FRJ4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methionine adenosyltransferase 2 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Methionine adenosyltransferase II beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_299978</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX90174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX90174">
        <property type="protein sequence ID" value="EFX90174"/>
        <property type="gene ID" value="DAPPUDRAFT_299978"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299978"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_0_0_1"/>
    <dbReference type="InParanoid" id="E9FRJ4"/>
    <dbReference type="OMA" id="AGETTWH"/>
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    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
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    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="5">
        <location>
            <begin position="5"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX90174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="269" mass="29546" checksum="C7E1B405832EDF95" modified="2011-04-05" version="1">MSSKRVVITGASGLLGRAVLAAFKNSQWTVLGTSFSRTGEDLVSIDICNHAKTEELIRNFMPNCIVHCAAQRFPDKVDKDLDGTIRLNVEATKNLAVLAAKLGATMIYISTDYVFDGTKPPYSETDTPNPLNTYGKTKLQGEQVTLESSQDHIVLRVPVLYGPVEYIGESAVTVLLQLLFDSESNKLVSDSEIRYPSHVDDIAFICVKLLELKQTNADVKGIFHWGGKESMTKYGMVQDIASVFQLPMSHISPDPNQSQGASRPHNAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSN9</accession>
    <name>E9FSN9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_232909</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89233">
        <property type="protein sequence ID" value="EFX89233"/>
        <property type="gene ID" value="DAPPUDRAFT_232909"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_232909"/>
    <dbReference type="HOGENOM" id="CLU_2608436_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX89233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="79" mass="8714" checksum="DF1FCF7BF0A6C037" modified="2011-04-05" version="1">MGNHMGRPAALLIARIDRRPVSTNAAHFSCPPPSPCIIISMQLLNFQENTLTWTDGNLRASTRVLLSPLEENSSLDEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSS5</accession>
    <name>E9FSS5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BUD13 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_190512</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89771"/>
    <dbReference type="EnsemblMetazoa" id="EFX89771">
        <property type="protein sequence ID" value="EFX89771"/>
        <property type="gene ID" value="DAPPUDRAFT_190512"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_190512"/>
    <dbReference type="eggNOG" id="KOG2654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024195_3_0_1"/>
    <dbReference type="InParanoid" id="E9FSS5"/>
    <dbReference type="OMA" id="VYRQKQT"/>
    <dbReference type="OrthoDB" id="1558074at2759"/>
    <dbReference type="PhylomeDB" id="E9FSS5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX89771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="502" mass="56763" checksum="7FDBE49C06767D1C" modified="2011-04-05" version="1">MSAPMSKLEYLKKYMSSSKKEENKVKKKKLRPLLKAKGGIKIVDEEIDLRKIAAGYEKDEDQIDNQEDAPLVAGVVDNRSIEMITKQDFVESSKWKRLGVDENDKPKSMSKSSDGRDIDSGDSHLPRKDSTALKRPITVKKERHDSDSDPSPPRRRHDSDSDASPPRRKRHDSDSDPSPLRRTRKDSDQSPPRKRHDSDSDASPPRRTRKDSDQSPKRKRHDSDSDQSPLRRRKGSDSNQSPPRKHQNADGDLSPRRRKKNVDSGAQMRIKPDPDGDLSPERPNKSTSRSGGASEKLTKTLDGKMAGLQTGRALREETEALRKREEEAFRKMDKSLTGQNATTAIRAGKLRQIEAKQQVDKEKAEKIAKLQEAYQKWNKGLKQGETHSTQVAEAIHEMSKPLARFADDEDLERLLREQDREGDPMAAYMAKKKVKSGGDGKGKAARPVYRGPAAAPNRFGILPGYRWDGVDRSTGYEKMYFEKQNNAVALQEEAYKWSVSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9FTA7</accession>
    <name>E9FTA7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_205806</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89677"/>
    <dbReference type="EnsemblMetazoa" id="EFX89677">
        <property type="protein sequence ID" value="EFX89677"/>
        <property type="gene ID" value="DAPPUDRAFT_205806"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_205806"/>
    <dbReference type="eggNOG" id="KOG0315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_5_1"/>
    <dbReference type="InParanoid" id="E9FTA7"/>
    <dbReference type="OMA" id="VQRNYKH"/>
    <dbReference type="OrthoDB" id="779909at2759"/>
    <dbReference type="PhylomeDB" id="E9FTA7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="PTHR19842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX89677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="321" mass="35634" checksum="EAE03BB2FF3EFEED" modified="2011-04-05" version="1">MGNNNGDQVILATGGYDHSIKFWQAHSGVCTRTVTHPESQVNALDITPDSQLLAAAGYQHIRMYEINSSNPNPIVNYEGISRNVTAVGFHEDGHWMYTGGEDCSARVWDLRTRNLQCSRIFQVTAPVNCVCLHPNQGELLVGDQSGVIHIWDLRTDHNEQLIPEQDASIQDISIDSSANFMAAINNKGNCYVWSLIPGNKLPDGEEGSTQTQLRPKSRLLAHKRYGLKCKFSPDAKYLATTSADQTAKLWKTSDFSLHSTLQTENQRWVWDIAFSADSQYAITASSDNTARLWSIETSEIAKEYIGHSKALTSLAFQDGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9FVK6</accession>
    <name>E9FVK6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_15798</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
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                <person name="Basu M.K."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="SSF56968"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Vitellogenin" evidence="3">
        <location>
            <begin position="31"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="4">
        <location>
            <begin position="1413"/>
            <end position="1631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX86756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1644" mass="182981" checksum="F04E96C1387E6CB6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9G2U5</accession>
    <name>E9G2U5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbonic anhydrase</fullName>
            <ecNumber evidence="4">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CAA1</name>
        <name evidence="6" type="ORF">DAPPUDRAFT_442498</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="GL732530">
        <property type="protein sequence ID" value="EFX86103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86103"/>
    <dbReference type="EnsemblMetazoa" id="EFX86103">
        <property type="protein sequence ID" value="EFX86103"/>
        <property type="gene ID" value="DAPPUDRAFT_442498"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_442498"/>
    <dbReference type="eggNOG" id="KOG0382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039326_2_1_1"/>
    <dbReference type="InParanoid" id="E9G2U5"/>
    <dbReference type="OMA" id="SADFPNF"/>
    <dbReference type="OrthoDB" id="1377476at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="PTHR18952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="SSF51069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX86103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="270" mass="30633" checksum="0D42D3A37C3EDA60" modified="2011-04-05" version="1">MAHNWGYKSTNGPHTWAEHYAEAAGERQSPIDIQTSDVTLDPKLSSRQLTWNWPKHTVDVTNTGYCWKAHVHGEESSLEGGPLKDKYQLEQYHCHWGVNDNVGSEHLVDGKAYAAEIHFVHWNTKYGSFSEALKHGDGLAVLGVFVEVGKEHGEANNLIKALNNIRFKDETVKFNDHLELDPSKLMPANEPRSYWTYLGSLTTPPCSECVIWIVYKEPIQMSHEQLEAFRAMYCGDKEQCCAANEMAECILTNYRPCLPKGERCVRASYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3F6</accession>
    <name>E9G3F6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_222355</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85765">
        <property type="protein sequence ID" value="EFX85765"/>
        <property type="gene ID" value="DAPPUDRAFT_222355"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_222355"/>
    <dbReference type="HOGENOM" id="CLU_987865_0_0_1"/>
    <dbReference type="OrthoDB" id="1701926at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX85765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="282" mass="31970" checksum="1F0EB30634F71259" modified="2011-04-05" version="1">MDEKPGDWDWEDGISRGFQQMVQIQDKETGECWTVAKETDCMGACGESKAMCSRIKQSVSGWKIPKEYSLLGSTSSFKAEGVQPVFTTVDSDVQMNSSWTCENDDSSDQTAIIATFPSPGKLPAFCRKRRCSVSAAAAKIDSSAKPTKNPVGNSAIERFLEGRERLLFVGRLLFAFLVLLSPGYFFPLLFFIRTYCHFWKHNASVDQEEEVFERTHSGPFSFFHAKAFLKYSCRLCREKIKTEKMFRIHSKIGSSSSFHKNAAFSEPEVQDYSDDCPHNHFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3L1</accession>
    <name>E9G3L1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_45536</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="gene ID" value="DAPPUDRAFT_45536"/>
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    <dbReference type="eggNOG" id="KOG1987">
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    </dbReference>
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        <property type="term" value="P:regulation of proteolysis"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BTB"/>
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    </dbReference>
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        <property type="entry name" value="SSF54695"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="73"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX85970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="147" mass="16898" checksum="B41F6605A63F6239" modified="2011-04-05" version="1">MFQKSFIESQTRQVNIDDIEMEVFRQLLIYLYSGDAPKLASDEVDVKTTQLLFEVADKYAVETLKKECVNVLLKEVDAENVIKLLVWSNFHSITELFDGAMKVLVDNFRAISFQPEWLDFMKNFPDLCLVATQRMSALLPPSTHSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9G5C6</accession>
    <name>E9G5C6_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">MAP kinse-ERK kinase</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_46211</name>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85655"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_46211"/>
    <dbReference type="eggNOG" id="KOG0581">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="E9G5C6"/>
    <dbReference type="OMA" id="IAGWVCK"/>
    <dbReference type="OrthoDB" id="688282at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:MAP kinase kinase activity"/>
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    <dbReference type="GO" id="GO:0000165">
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    </dbReference>
    <dbReference type="GO" id="GO:0006468">
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
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        <location>
            <begin position="185"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX85655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="297" mass="33142" checksum="53037EC3627DF359" modified="2011-04-05" version="1" fragment="single">LIHLEVKPAIKKQIIRELKVLHECNSPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKKAGRIPEQYLGKITIAVLKGLSYLRDKHQIIHRDVKPSNILVNSRGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSIQSDVWSLGLSLVEMAIGMYPIPPPDPQVLANIFGAKFSEDPENMTPSPSSRSPRQSQFPGGVGNGPRPMAIFELLDYIVNEPPPKLPSGVFSVEFKDFVDRCLKKNPAERPALRTLMGHEWVKKWTSENVEIAGWVCKIIDLQPSTPTKHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9G603</accession>
    <name>E9G603_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_238276</name>
    </gene>
    <organism evidence="3">
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX84853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84853">
        <property type="protein sequence ID" value="EFX84853"/>
        <property type="gene ID" value="DAPPUDRAFT_238276"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238276"/>
    <dbReference type="HOGENOM" id="CLU_2335707_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="98" mass="10221" checksum="229A1C25409E11BC" modified="2011-04-05" version="1">MAPVEDVVPVWLGSEGVSHSVLPDVATISRPHAALAVNSMKQTSRNRAPVKSKMAGRSTSRLTLAAATSAKISPEGCGGIDLSHPFYQNPLTVVAGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6M4</accession>
    <name>E9G6M4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Brother of odd with entrails limited-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BOWL2</name>
        <name evidence="4" type="ORF">DAPPUDRAFT_238529</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Manak J.R."/>
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                <person name="Arnold G.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX82324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="72" mass="8147" checksum="0D7F9982704E9D2B" modified="2011-04-05" version="1">MPASYTDPCFVRNSVLWTTGSSDAMNSSHFVSHHFYHQSLLPKAHCIDKDNKTNDEPADRSDFLFGTISQQN</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CH-H</strain>
            <strain evidence="6">PA42</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="SVE84002.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="SVE84609.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX82013">
        <property type="protein sequence ID" value="EFX82013"/>
        <property type="gene ID" value="DAPPUDRAFT_302797"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302797"/>
    <dbReference type="eggNOG" id="KOG1754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S8_sf"/>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SVE84609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="130" mass="14744" checksum="6E0E31984B2F60C5" modified="2011-04-05" version="1">MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVKFLTVMMKHGYIGEFEIVDDHRAGKIVVNLTGRLNKCGVISPRFDVPIRDIEKWSNDLLPSRQFGYVVMTTSAGIMDHEEAKRKHVGGKILGFFF</sequence>
</entry>
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    <accession>E9GI85</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX80634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_50825"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
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        <location>
            <position position="1"/>
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    <feature type="non-terminal residue" evidence="2">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="256" mass="29254" checksum="D2B10A7AB99E8D56" modified="2011-04-05" version="1" fragment="single">EPWQQERPVNLPQIQNLEVMCAKDHMEVQLSFDKPFTGLVFSKGQFGQDNCVYVHPKSSRTNFRFSIIYNGCGTKPDAKGKFYENTVVVQYDEELIEVWDEAKRLRCEWYNDYEKTATKPPMVIADLEVVELNFRGDNVDCWMEIQNGKGPWASPISGIVPLGSTLTMVVAINDLAGEFDMRVKSCEASDGVNRPIQLSDEHGCVLRPKMVSKFLKLRSNDGRSTVMSYAFFHAFKFPDSLQVYIRCKVEICRHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9GI86</accession>
    <name>E9GI86_DAPPU</name>
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            <fullName evidence="2">PARG_cat domain-containing protein</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732546">
        <property type="protein sequence ID" value="EFX80635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80635">
        <property type="protein sequence ID" value="EFX80635"/>
        <property type="gene ID" value="DAPPUDRAFT_243206"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_243206"/>
    <dbReference type="HOGENOM" id="CLU_940930_0_0_1"/>
    <dbReference type="OrthoDB" id="730627at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARG_cat" evidence="2">
        <location>
            <begin position="2"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX80635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="296" mass="32188" checksum="E2A3B163848BECBC" modified="2011-04-05" version="1">MCLIDAEDYSDLPIRQYEEDNVLRELNKAYLGFSQHYPDATAAAGLEQQQPQEQLQQRLPPVGASRDSSPSSRQASTIIGTRFGIGHRDFVHFYLFISFSAGPDYTMSQDWADLTRSTTLVASSGDPSSPRPSLCPSMPSQDLQSHLPGDETDRGRPAAAATHPTLLYGGGRNAPLTLAKATVVKQILTQQQQQQPAKAKDGPPDLSKLPSSVVAAAARKAGSVYASCHSQDDELNSSTEEFRSANTSLDEDEIRPALINRLQQQQRHSAGDSNQDGREDNKSRSQSTESDSSSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJ45</accession>
    <name>E9GJ45_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_318539</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80549"/>
    <dbReference type="EnsemblMetazoa" id="EFX80549">
        <property type="protein sequence ID" value="EFX80549"/>
        <property type="gene ID" value="DAPPUDRAFT_318539"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_318539"/>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057004_0_0_1"/>
    <dbReference type="InParanoid" id="E9GJ45"/>
    <dbReference type="OrthoDB" id="1633689at2759"/>
    <dbReference type="PhylomeDB" id="E9GJ45"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="SSF57625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237107" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="382"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX80549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="439" mass="48032" checksum="516444D46FFD5388" modified="2011-04-05" version="1">MHLKCLSLVIASLLLVMTSAMAVQSEGDRAVCPEDFSPCTCDSSAGGQNVVCDQVSVQEIKSLFSRTTAADLASFKLTTSTSEVSGIPADFLGNTRASSISINCSSTSYELTIDDNAFASSATFTKTVSISGCYFVQQRNFNFLSGFGDMTALNIFNSRNFTSFQGLPSQPNLYYISIVNCRGFDSLVNEGKITLSGLKNLYLYDNELNDRSAATVLSSLASASIESLEELRLYNNRLRRIPALIPSFSKLNQLMMENNNIDLIITRSLSFYNDVSYLHLGNNAIRSIEPSAFGAHRFGTVYLHQNNLTRFESYVFQTMLEGMVQAGYGSVSLYENPIDCDCHLAWLILHKPELLAVVDGGQCSDSIMFTDLNPDAFVDCPVFTCPANIDGNFPNPLSCSSYYVCSNGNDVLVECPGGLVFNPAYQLCDWAYNVPTCNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9GL17</accession>
    <name>E9GL17_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_104014</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the bestrophin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732550">
        <property type="protein sequence ID" value="EFX79869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79869">
        <property type="protein sequence ID" value="EFX79869"/>
        <property type="gene ID" value="DAPPUDRAFT_104014"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_104014"/>
    <dbReference type="eggNOG" id="KOG3547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018069_8_0_1"/>
    <dbReference type="InParanoid" id="E9GL17"/>
    <dbReference type="OrthoDB" id="279144at2759"/>
    <dbReference type="PhylomeDB" id="E9GL17"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin/UPF0187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="PTHR10736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX79869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="430" mass="49118" checksum="67CF6A83DD2E0000" modified="2011-04-05" version="1">MSSNISMQYSTRNERVNAITEIPLNNLNASQQQTSTTAVPIWHNNTTKHPAISSILDTPAQQSRSSVFGESFLTLFQWKGSIYKALWKHFVIYCALYYLLTVVHKVALNGEQKKAFEALAKYCMTNPPSPTNLIIMLSFFTTTAMQRRFSVQINMAGTSRLISVFVMGLKPNLREGPVIVEHYARWVVLSWVLTYRIVCKPLRDLFPRYSRRLNVLMLIRKCNEFYFFKDMTSLQRAGIIQNSAERMILEKMETEGDPTPRPLVVIDWMTLLIKKTHKKGRFAEYKYYLQSVENVLAYKKNCGNTIKFATKNIPYALIQVAVIVVYLYGVFTLMARNFDGVEKSVLLGGIVNYFPGFSSIQFFIFLVWLNFGRTAVNPFGSDDDDIDVKQLLATHIQDSLRLAKLYHQDLSDFLGEIVLPNQNAAASAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9GL32</accession>
    <name>E9GL32_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nuclear nucleic acid-binding protein C1D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_304365</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer and homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the C1D family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732550">
        <property type="protein sequence ID" value="EFX79784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79784"/>
    <dbReference type="EnsemblMetazoa" id="EFX79784">
        <property type="protein sequence ID" value="EFX79784"/>
        <property type="gene ID" value="DAPPUDRAFT_304365"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304365"/>
    <dbReference type="eggNOG" id="KOG4835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064339_4_2_1"/>
    <dbReference type="InParanoid" id="E9GL32"/>
    <dbReference type="OMA" id="KLMSMPR"/>
    <dbReference type="OrthoDB" id="1436833at2759"/>
    <dbReference type="PhylomeDB" id="E9GL32"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="PTHR15341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX79784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="165" mass="18469" checksum="558F60B542A05AA4" modified="2011-04-05" version="1">MEWVKHKDFPEEMTANAQNLDSALSEMEAVVNALTSVPLTEVQSCLKPIERSKYDTASVYAVTSLFWAYMKTRGVDPKTNGLPRELERVKSAIGRSKEIVDRALAPKVDISAAKRFIRGGLWEPKDSEQREGSNQEKSDVSKPPPNKRIRFDDAGSTELTNNAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9GLT8</accession>
    <name>E9GLT8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_304503</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732551">
        <property type="protein sequence ID" value="EFX79563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79563"/>
    <dbReference type="EnsemblMetazoa" id="EFX79563">
        <property type="protein sequence ID" value="EFX79563"/>
        <property type="gene ID" value="DAPPUDRAFT_304503"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304503"/>
    <dbReference type="eggNOG" id="KOG1455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026209_7_1_1"/>
    <dbReference type="InParanoid" id="E9GLT8"/>
    <dbReference type="OMA" id="KPRWPIP"/>
    <dbReference type="OrthoDB" id="919091at2759"/>
    <dbReference type="PhylomeDB" id="E9GLT8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:acylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="39"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX79563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="250" mass="27693" checksum="8C6E2C4C1EB71BA9" modified="2011-04-05" version="1">MVSKKSTNGGGHHTNPVPEQLRIKCGKKLHCRYWEPTVSPRGLVMLIHGLAEHLGCYEELGCRMAAENFLAFGHDHLGHGMSDGHRVHVESIDDYVVDILNHIQLMREEHPQIPIFAVGHSMGGMILLSAALKEPTAFDGVVLMGPLIHIDPNLASPVKLWAARLLSRVTPHLAVSKLTVEHITSDQGEQELIKNDPLVWKGGVKCKWATATHECLVEINKKLTSMKVPFAVLHAEQDKLGAINNFQFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9GLX1</accession>
    <name>E9GLX1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_31061</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732551">
        <property type="protein sequence ID" value="EFX79619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79619"/>
    <dbReference type="EnsemblMetazoa" id="EFX79619">
        <property type="protein sequence ID" value="EFX79619"/>
        <property type="gene ID" value="DAPPUDRAFT_31061"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_31061"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006130_2_1_1"/>
    <dbReference type="InParanoid" id="E9GLX1"/>
    <dbReference type="OMA" id="IAAPLKC"/>
    <dbReference type="OrthoDB" id="559381at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007190">
        <property type="term" value="P:activation of adenylate cyclase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F1_2" evidence="10">
        <location>
            <begin position="171"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX79619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="429" mass="48468" checksum="FA4B6881AD5A3D40" modified="2011-04-05" version="1" fragment="single">MLGGNKLSDLSASTFHGLDRLKWLFLYRNQLGNTTSMKVFHPLTSLRWLFLNENRIQMIRNNTVASLSNLILLDLSYNMLEYVSENLFRSQRNLTQLRLQDIDIPDISEEMFAPSTLLDFAYFKNFRYCSYVAHASKCQPLSDGVSSFSDLISHGVHRAFLWIIGVLTIVGNALVLGGRNLAKTENRILAMFVKNLAAADMCIGIYLLCLGERDISFRGQYNQHAHQWMMSWQCTVIRVLAVSTSEVSLLLLTFMSVERFVSISHPFGERTLNFRAAFISTALIWTVGLALSLIPVLYWSEMGRHHGSNGLCFPLHIHEPSALGWQYSAFLYIGINGSCVLVIVGVYTALFVSIRRTRTATPLAPNEIEIAVRFFFIVFTDCLCWMPTILLKIMALANVYIPADLYAWLVVFILPVNSAINPLLVSLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>E9GM17</accession>
    <name>E9GM17_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DAPPUDRAFT_104369</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="EMBL" id="GL732552">
        <property type="protein sequence ID" value="EFX79285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79285"/>
    <dbReference type="EnsemblMetazoa" id="EFX79285">
        <property type="protein sequence ID" value="EFX79285"/>
        <property type="gene ID" value="DAPPUDRAFT_104369"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_104369"/>
    <dbReference type="eggNOG" id="KOG0196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_141_4_1"/>
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    <dbReference type="OMA" id="IGWTTHP"/>
    <dbReference type="OrthoDB" id="933071at2759"/>
    <dbReference type="PhylomeDB" id="E9GM17"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033674">
        <property type="term" value="P:positive regulation of kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:transmembrane receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027936">
        <property type="entry name" value="Eph_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016257">
        <property type="entry name" value="Tyr_kinase_ephrin_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14575">
        <property type="entry name" value="EphA2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000666">
        <property type="entry name" value="TyrPK_ephrin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SSF47769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="SSF57184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
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            <begin position="495"/>
            <end position="518"/>
        </location>
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        <location>
            <begin position="580"/>
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            <position position="606"/>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E9GN22</accession>
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        <name type="scientific">Daphnia pulex</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GNR3</accession>
    <name>E9GNR3_DAPPU</name>
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        <submittedName>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="76" mass="8590" checksum="19D517C863A8C24F" modified="2011-04-05" version="1">MFDWMDVKVLAGQLKGLDWPRGISDVASSPCTGRQLAMPAIYPSTAGLLMNYQQRSHNFYDQWLHASFSISSDGWH</sequence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="169" mass="19007" checksum="131476F576F6B9F3" modified="2011-04-05" version="1">MFHSEDAPWRDLTGNGRIPLVQHESAGSFSTRRQEIGHRLQFSVRWETRNFVDVRVMTDEILFGLSSGLLWFAWAIKHRQIDYNAPSGVCRCNSQIRISSSGQAVGAIDFTGCLSCPRSFADVYSTARLQSARFIPSYLSIYWSSANVVAIAKIRLELDFDCSSSTGFK</sequence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX77911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX77911"/>
        <property type="gene ID" value="DAPPUDRAFT_320939"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_320939"/>
    <dbReference type="HOGENOM" id="CLU_2090747_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="EFX77911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="123" mass="14139" checksum="CBA2285B5365C287" modified="2011-04-05" version="1">MLKDLQGIKGCVVFMDAMNSTVSERYPLCKEDFHVLVCECASDEWKDLARTVTEGTASFQQMEEIIRISPDPDVLSRKHLHGIVFEGVSVAYREIKTLQELRHFISPFVTALRFFTIRAKEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9GRS5</accession>
    <name>E9GRS5_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_305327</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732560">
        <property type="protein sequence ID" value="EFX77825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77825"/>
    <dbReference type="EnsemblMetazoa" id="EFX77825">
        <property type="protein sequence ID" value="EFX77825"/>
        <property type="gene ID" value="DAPPUDRAFT_305327"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305327"/>
    <dbReference type="eggNOG" id="ENOG502QUBC">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="PhylomeDB" id="E9GRS5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="KICSTOR_ITFG2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EFX77825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="406" mass="45592" checksum="C02D52F86DB4CD9E" modified="2011-04-05" version="1">MRAVSYVERLEFDFPGSVFKNAFLFGDVDNDKCEELVVGNENGDVYIYKGSASKCWRRASDLGMVTAIGVGDIFNAGRNSLVVVNGEGWCYIFDFLTDTCSDGELPMKPTHVQRIPANTKVLLLHDVNSDGMIELVIGLTDRVVRTYQWINTKLVGLNKWEFANQIGTVGINDMANRTPSLLVAHPGGTFIRLKCKPLENCEDHGKEEPRELLSKMSIDYHPLAYSHMRNPNVSTEILGNISQGISHQDENQGALYAVATLDGTLMMVRDEQILWSLQVDHQLFALSKLDITGDGREEVVACSWDGQTYIVNQEKQTVRFQFDQSVSAFTAGYYSLNSQSSSLPAFAYATFHNKIYVYYNVSLPRITLHTSSELLKTKSENLDENLLKYLTNPSKLSEIFAKTLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTE7</accession>
    <name>E9GTE7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX77372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX77372"/>
        <property type="gene ID" value="DAPPUDRAFT_247805"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_247805"/>
    <dbReference type="HOGENOM" id="CLU_649360_0_0_1"/>
    <dbReference type="OrthoDB" id="1437269at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="423" mass="47390" checksum="E1D61150A77AAB83" modified="2011-04-05" version="1">MSTGLGSLNIDMRITASLKDSDVVVVSIHDVSCRCGNFTVTLETMIVWNVPLTRSSFSIGDCMSEFLTDEEIKDRECLCCSHGEAVMKKTVVVWPRVLIVFLQRFSNREKYEAPICYPEMWQPVEREKDSDQDYILRAVVTHLGETMESVCIPTESLLSYCNIMAGLIFSVCLYSQSSQNGKEEEDYMLFVVTGSGHSRRLLDAAECGARQVQQQPPELKSETRWGSNIPTVLSDQCTSVPRHQLACFLSSLLPFRTQNKNSGVKEKETTNRHSVDAKLTGIGDVGLRETFFFDIFLCARVTREKTKMGDYFGRRSEDRGSARCWTWSVDIIVPGTSVGSKGEVKLMINKITMSFNADAAMDFGAFVIRQSAPFVTGGCIFYVSPFVALLLLLMVLKAVASPFDCYNQLPEAFRESAIHDGMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9GU27</accession>
    <name>E9GU27_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_306017</name>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732565">
        <property type="protein sequence ID" value="EFX76964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76964"/>
    <dbReference type="EnsemblMetazoa" id="EFX76964">
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="873" mass="95041" checksum="76370497FDDE5DAA" modified="2011-04-05" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="321" mass="37477" checksum="725796D446CF4F0E" modified="2011-04-05" version="1">MHNYALLLIVELMQVIQKEWEAKNSVYAKFESSKGSMRNYFDLVSKGAAKTKIFSSTMANTLSDVAFSSFEEEMVAKTYRKISNERWIHEARIMHKHMDLYLIDLLEANQIDQVLDYIDDPKTFYTCVLRRLIALKVPNVANDVSNEGEWTRFKRQVKDAVKKAALATLDGTNKELAQTFVDKLRDDGEYEECDNEDKKKFQEDCEKELNEAIENVNSLNDHEGFAKELSPEVVDQFYEEDCSFYFSKEDTVAKKYRDFTKIYPSWKDPRINEESPLREYILATYNNKIAEKCGLKPCPDVPQSYFRVLSTIKEQLKMEID</sequence>
</entry>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="METTL24"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="290" mass="32566" checksum="002A3CEEB44ACC00" modified="2011-04-05" version="1">MAGQKAICIDSKVAPQPGNCLIYSFGIGGEWSFDEQMERYGFQVYAFDPLMGLDQHDHSRASHFYNWGLRNRDEFNIYENWTVRSLSSIYETLSSDRLKRLSPPSKKLLISKTFHRSSSLGQQFLFFPGVTLAFSGKLLIVDDFNIHLEHASDALTLRFLELIDSFGLIQLVRESTHIKDGILDLVLCCSGDSLVLSADDIKLPQHKSVEEIFDVLGSYFQAKILNFRSGLDSIPVGDSEDIPLSLVDEKLSSFRPVSATEITSMFNSRLMVNRLRIAGSLGAWMKHGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0E3</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase RNF170</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RING finger protein 170</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">RING-type E3 ubiquitin transferase RNF170</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DAPPUDRAFT_56655</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="GL732580">
        <property type="protein sequence ID" value="EFX74792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74792"/>
    <dbReference type="EnsemblMetazoa" id="EFX74792">
        <property type="protein sequence ID" value="EFX74792"/>
        <property type="gene ID" value="DAPPUDRAFT_56655"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_56655"/>
    <dbReference type="eggNOG" id="KOG2164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072335_0_0_1"/>
    <dbReference type="InParanoid" id="E9H0E3"/>
    <dbReference type="OMA" id="NGLMIMF"/>
    <dbReference type="OrthoDB" id="1563172at2759"/>
    <dbReference type="PhylomeDB" id="E9H0E3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038896">
        <property type="entry name" value="RNF170"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22894">
        <property type="entry name" value="PTHR22894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014068"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFX74792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="231" mass="26110" checksum="7759EBA0B2AA711A" modified="2011-04-05" version="1" fragment="single">VHPEERENVNLLRESMRGTKIQPRRRYGQQNQCPVCLNDIEYEVETNCGHIFCCRCWLAYRAHGSFLGAVRCPVCRQQVTILFQGFSENELNPASGSDEEPDLATFIREINSYNRRYSGEPRPFWENIRELPVLFRHILSEVFSEGGFLYLYRLRVSLLVIGCVIYLLSPLDIIPEAAFGLLGLVDDLLVLLVVAVFITNVYRTYIANGGNIFGSYNQPPAAAAPADASSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2X0</accession>
    <name>E9H2X0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_252532</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX73940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73940">
        <property type="protein sequence ID" value="EFX73940"/>
        <property type="gene ID" value="DAPPUDRAFT_252532"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_252532"/>
    <dbReference type="HOGENOM" id="CLU_2087242_0_0_1"/>
    <dbReference type="InParanoid" id="E9H2X0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX73940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="117" mass="12380" checksum="291B5D3597E68B0B" modified="2011-04-05" version="1">MANVASLTSKRGGNRGSVTRFIAKISDIIANVAMDRDRKIRELNKKLGDLHDKIKVVEIAEVAADAAAAAAAAAVANPNPSAATNTPTINVTTATDLSHLPKFNLQHPHVERLLGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9H3R7</accession>
    <name>E9H3R7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_109657</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732589">
        <property type="protein sequence ID" value="EFX73564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX73564"/>
    <dbReference type="EnsemblMetazoa" id="EFX73564">
        <property type="protein sequence ID" value="EFX73564"/>
        <property type="gene ID" value="DAPPUDRAFT_109657"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_109657"/>
    <dbReference type="eggNOG" id="KOG1292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1760648_0_0_1"/>
    <dbReference type="OrthoDB" id="387031at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098590">
        <property type="term" value="C:plasma membrane region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015229">
        <property type="term" value="F:L-ascorbic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX73564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="148" mass="15931" checksum="DF8FC2B3C35AC6AF" modified="2011-04-05" version="1">MTFRQDRQPQRTIKSTSSTRPLGSGFPKYPCQWSLPTVSVAAVSGMLAGVLASAIESIGDYNACARLWQMKANPGAINSGSQIFDQMVTVLMGTSMCITAGALGSFLDNTIPDPIGRSKEWEGKELVENKCEDKPNGKTAAIWMSPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9H4Z5</accession>
    <name>E9H4Z5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_325519</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX73270.1"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="21"/>
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        <location>
            <begin position="22"/>
            <end position="230"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX73270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="230" mass="24584" checksum="A2303510AF22A7AC" modified="2011-04-05" version="1">MRRSLYGILLLVCCAISSVCAAPSSAVIGNELSGGLARESRQLIPDEKGTCFALGSGGPCSSTQLLGYDIFKRQLQCVVDPFSPESSPSQQNELVDGAENKELFSQDYISERIGWIEYLISISLSQRRYLMEPIERQDTAGILQLPSSLPDSLLLPCRTGARSDNNFKCANPLVSDSGSGGSLPPMPPLVTCPADSFLTASGSCVDDSRAAKCGPSTRFNEATGQCRSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Daphnia pulex</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502RYGN">
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    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="3 4" key="1">
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                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
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                <person name="Laforsch C."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_953972_0_0_1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5003240930" evidence="2">
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="292" mass="33527" checksum="A83043829D00C1B6" modified="2011-04-05" version="1">MWRIGWKKRLSVLLKSEVVLAALYLDPRYNVMLEEDQLKSAQKNLIKLWRLIEFNKNDPPANTTLLLQPMQTNKNEVGLTNDELQEIMFKKEAELREKTNSKANEATIEKMIQDFVKYKLIARSTDVLKYWEDNRLLQHQLSLRTKEQLQLAESNEEESMDTRETDVPITKETPNEEEACPVSAMEDEIPLITDETLREESNVPTDPLIHNEVTQETKMIIDQDAHDTTPIAAEVPQVGNIDQPRQSTRIRARHIQSAAKQAVLSNDSANQDSTVNPTEPGTYCEEIKWDGG</sequence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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                <person name="Manak J.R."/>
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    <dbReference type="InterPro" id="IPR032498">
        <property type="entry name" value="PI3K_P85_iSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035022">
        <property type="entry name" value="PI3kinase_P85_nSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16454">
        <property type="entry name" value="PI3K_P85_iSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SSF55550"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="283"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX71402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="395" mass="45584" checksum="7F5D20F9CB37CF1E" modified="2011-04-05" version="1">MSEADWYWGNITREEVNDLMKDTPDGTFLVRDASSKAGEYTLTLRKGGSNKLIKICCSRQGRYGFSEPYRFSSVPELIHFYRSVSLAQYNPTLDVKLLYPVSRFQHAEEVEAGNGDVEKMRQRLEDVHHEYLARSRLYDQYHDDYSRCSQEIQFKKQALDAFDEAVAMFEEQLRLQEKFQREAHRHEIHSLKENNELLKSRMNTLKLSRQELQEDLRVQAVLSRNLDREMNALKPELHQLCKTRDLLQMWLLRHGKNPEMPAGIENKAYDGTGDGPAPPVTYWLIPDCTRPDAERLLSNKADGTFLIRRSAAGSAPFALSIAYRRVDKGVGHILIHRSERGFGFTEPYLLFPTLNDLVVYYAGHSLEEHNPQLTTTLAHPLHGPQPLESNPHYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9HAB8</accession>
    <name>E9HAB8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_255908</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732611">
        <property type="protein sequence ID" value="EFX71277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71277"/>
    <dbReference type="EnsemblMetazoa" id="EFX71277">
        <property type="protein sequence ID" value="EFX71277"/>
        <property type="gene ID" value="DAPPUDRAFT_255908"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_255908"/>
    <dbReference type="eggNOG" id="KOG2227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012774_3_1_1"/>
    <dbReference type="InParanoid" id="E9HAB8"/>
    <dbReference type="OMA" id="IVNCAST"/>
    <dbReference type="OrthoDB" id="935804at2759"/>
    <dbReference type="PhylomeDB" id="E9HAB8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="57"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="4">
        <location>
            <begin position="319"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX71277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="416" mass="45992" checksum="4F04FCE09E7471EC" modified="2011-04-05" version="1">MDFDDDLVSPAKSPRKVTNFAKARQALHTSTPSNIFCRDKELAVIENFMRPLIEMSKPGSMYISGRPGTGKTACFSGKFRSIFINCMLLHTPSSIFQQIAQQLDPKWSALAKEALSFLEDKLTESGPMIVLVLDEIDQMSTRDQSVLYALFELPALKNSRLILIGLANALDLTDRALIRLQSRVQFKPVLLNFSPYSKQDIVTILSQRIREVVTEDVGNLIAPSALQYLGGKISSTSGDLRKAIDICRRAVELAETTAKKQLVLAPSNSEPQNSGSIPTNKCVNIPLLCKMMASVESNAFSTANNDDVDETPLQQKLIIVTLLVLVKFGKAKQVTLGKLHESYSKVCSKYGVTKIDFDEFSHTCSLVESRGIVTLKKKSNSRLAPICLRLDEREVESTLKDKTLLSSILAQGTLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HC17</accession>
    <name>E9HC17_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_256768</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732618">
        <property type="protein sequence ID" value="EFX70689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70689">
        <property type="protein sequence ID" value="EFX70689"/>
        <property type="gene ID" value="DAPPUDRAFT_256768"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_256768"/>
    <dbReference type="eggNOG" id="ENOG502SXXC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047623_0_0_1"/>
    <dbReference type="OrthoDB" id="1390724at2759"/>
    <dbReference type="PhylomeDB" id="E9HC17"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="262" mass="27442" checksum="3DFF663612641AE0" modified="2011-04-05" version="1">MACAAVSAQIPVGWNYNPFLYYPFTAQPAPVQETAEVAAARAAHLAAHTSAGGSNNRVVAVQPVPVWGQPAGAVLDTPEVWAAKVEHYRAHSAAAAANGVVSTLAPLPVVSWGVPQPVQDTPEVAAARAVHLAAHAATRGKRSVQQDTPEVMAATLEHYRAYNAAAAANEIMAYLPARYANMPFGMPQQVQETPEVAAARRAHLAAHAHAAARGAKVQVVPVQPLPSAVVLAPPQPVQDTPEVHAAKMVFFRAFHEAAVRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDA7</accession>
    <name>E9HDA7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_112868</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Rho M."/>
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                <person name="Shiga Y."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Tang H."/>
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                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <location>
            <begin position="20"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="145" mass="16166" checksum="9542E2504E7BAB6A" modified="2011-04-05" version="1">MGRLVRSRLKAGINMRRDSYFLVVSCTSLLLYAICLYTFLHLNGYIGAKNLVAAPSPSATGARGHLDPNAADKNSQFFAAPYLKSQAQFDDGKIHEFQLNVGHPVDWEMRVKGNFGIIFEKTPKDNCVDIFHPFGDKHQTSSMVT</sequence>
</entry>
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    <reference evidence="1 2" key="1">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EFX70007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="106" mass="12448" checksum="4938165BC81BAF8A" modified="2011-04-05" version="1">MTQSDVYTEDSRLVMDLYSSTLLDFFFNITKLRKGVSTQIATQIQNFYIQLLKSISTLETGRYLFCAEARKLYFNVLSGFCRFLLRYKNAEIKHSYTGPHHHRSYG</sequence>
</entry>
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    <accession>E9HDZ5</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_257654"/>
    <dbReference type="HOGENOM" id="CLU_2348759_0_0_1"/>
    <dbReference type="OrthoDB" id="1879063at2759"/>
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        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
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            <taxon>Daphnia</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
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                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_113101"/>
    <dbReference type="HOGENOM" id="CLU_1344493_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HE26"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="206" mass="23913" checksum="9E0C050B259A8C3C" modified="2011-04-05" version="1">MNPEMKHKEPPPLKPCGEEVNIPVPDRIEPQRICLDIFRNPWSRDPTGKPSRLQRPERASQLELRPRPAQGRQSSSRAPVVNKPPPFRPSPPAVMKLAEFIPPTGQDRFYHPYSPRPVRLRPRSITPPGHPESEEDDFTPQLEDCTVRSEVGDCDYQPEEEPQVEKEQEAPVRNWRIRNTKTKVVRHVASNELFRPEKAHRIIKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9HEN7</accession>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX69788.1"/>
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    </dbReference>
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    </dbReference>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="150" mass="16305" checksum="387A1F6DDEF99A9F" modified="2011-04-05" version="1">MSPIPMPYADTLEVISAQLSSETGPIDCFSVYCPRGDCPPEDINLLFNRPNPFIIADDFNAHHSLWESNSTENTAGKSIHSTILDHPDAAMLTPLNIGTRIDPASGKESTIDLIFASSQFALNSTTSQEKATSMNKEKLGTEKNSTKCQT</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX69602.1"/>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PhylomeDB" id="E9HFI6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
            <dbReference type="EMBL" id="EFX69498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="108" mass="11469" checksum="72D04A0015FE6E4C" modified="2011-04-05" version="1">MTASKCISLFGTCCGTEPAIDKANEDPRKMKSSALCYTCYNSNISVKCTDDLLKTEDSLGAESCQRLGGVCCDATSNGGSAFNAEEYLYNHGSQTCNYCYSGIPQVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGW5</accession>
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
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        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phospholipase A2 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX69030"/>
        <property type="gene ID" value="DAPPUDRAFT_329536"/>
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        <property type="entry name" value="PLipase_A2_His_AS"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="PA2c" evidence="6">
        <location>
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            <end position="94"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX69030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="124" mass="14742" checksum="F0597C7176792EAC" modified="2011-04-05" version="1">MFKVILYTRASPLRLLYYGNWCGSGGMGPALDNIDQCCMTHDKCYGDVERLPCKGIFQTPYSVHYAWRWVEDRKQAYCRTYENQNSFSNRKIFELAFEIEIQNQCRDRRSGLHEREKKKVLVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9HIT4</accession>
    <name>E9HIT4_DAPPU</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_63218</name>
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    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68331"/>
    <dbReference type="EnsemblMetazoa" id="EFX68331">
        <property type="protein sequence ID" value="EFX68331"/>
        <property type="gene ID" value="DAPPUDRAFT_63218"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_63218"/>
    <dbReference type="eggNOG" id="KOG1281">
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    <dbReference type="InParanoid" id="E9HIT4"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:anion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:citrate transport"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
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        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX68331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="519" mass="56626" checksum="C14A18E5C3732445" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJJ2</accession>
    <name>E9HJJ2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX68121.1"/>
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    <accession>E9HME0</accession>
    <name>E9HME0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_115752</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732686">
        <property type="protein sequence ID" value="EFX67058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67058">
        <property type="protein sequence ID" value="EFX67058"/>
        <property type="gene ID" value="DAPPUDRAFT_115752"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_115752"/>
    <dbReference type="HOGENOM" id="CLU_1541672_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HME0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="174" mass="20208" checksum="7D470252D703535B" modified="2011-04-05" version="1">MVNRQTARKKGKKVMSFKKKNFEMKKKLRNMQKRLMKTAATFDAPEETFTVSVQAIQDRLEELKKNQAGFYAPEGSFPIRESVKLSVKEKCKKPEKGILEFFKELYPDSNFFELYKPTQKESTIGNKLKIAMDPKELKEIREKCLPKILFGSKGTTAWLRKNLVFVMTARDVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNB2</accession>
    <name>E9HNB2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_302434</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732695">
        <property type="protein sequence ID" value="EFX66779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66779"/>
    <dbReference type="EnsemblMetazoa" id="EFX66779">
        <property type="protein sequence ID" value="EFX66779"/>
        <property type="gene ID" value="DAPPUDRAFT_302434"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302434"/>
    <dbReference type="eggNOG" id="KOG3031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049783_1_1_1"/>
    <dbReference type="InParanoid" id="E9HNB2"/>
    <dbReference type="OMA" id="GCKIPRI"/>
    <dbReference type="OrthoDB" id="974865at2759"/>
    <dbReference type="PhylomeDB" id="E9HNB2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="PTHR12728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="7">
        <location>
            <begin position="29"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX66779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="297" mass="34067" checksum="355D5DCDA2383DF5" modified="2011-04-05" version="1">MSVRITKPKTHRGKRMLAKREPKIVELAKQALMLRGSTASVTSLQFVKDLYAIKRMQSTYFGQKHPYNPFEDVKPIEELTQKYDHSLFAFCSDNKKRPNNVILGRMFDHQLLDMIEFGVEQFKSLTAIRNAKVMDGNKPCLIFSGDVWHQNEEYSKCKSLLIDFFRGEVVEQVRLAGFEHALSFTAVDGKIFLRSYKILMTKSGTKTPHIELEEIGPSADLVIRRTKLASADLFKRACRTPSAAKPKKVKNMSKDVFGSKLGRIHMPRQDYRKLQVKRGRALRTEKSPKKASKLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9HP73</accession>
    <name>E9HP73_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transglut_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_116378</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732703">
        <property type="protein sequence ID" value="EFX66460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66460">
        <property type="protein sequence ID" value="EFX66460"/>
        <property type="gene ID" value="DAPPUDRAFT_116378"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_116378"/>
    <dbReference type="HOGENOM" id="CLU_1176467_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018149">
        <property type="term" value="P:peptide cross-linking"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_N" evidence="3">
        <location>
            <begin position="110"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX66460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="236" mass="26380" checksum="0202E7AFF0301540" modified="2011-04-05" version="1">MSSPLNQPGSPGMLRRSNMGQQGSPVMLRRSMSGSSGLNNLSHSGSFVRRNNDRDGMGNNVGVSPGGNNAAYRASLVSHYAEDLDRRRRAERAVEEIRTDGMPSDNLKIESVELFPRDNAREHRTDRYEMVFDNGREIGSPSSMMMSRSMTNMASMSSMSPMLSMDYRSSCAPSTTVLRRGQPFFFAVRMKDRNFDPRRDILRASFTFVGPDECAVTETTSMDVMATRALENEFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPH2</accession>
    <name>E9HPH2_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_263294</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732706">
        <property type="protein sequence ID" value="EFX66363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66363">
        <property type="protein sequence ID" value="EFX66363"/>
        <property type="gene ID" value="DAPPUDRAFT_263294"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_263294"/>
    <dbReference type="HOGENOM" id="CLU_2225832_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX66363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="106" mass="12663" checksum="8D6AF206CA6DE977" modified="2011-04-05" version="1">MSTPKKMKYAPAVAENEALVTAVTIKLRKVLNFRAKLRMYTDYDRQHHFTEDWIQGSKEEIEEEEIVKRFEYSKWLEEAATRKQLVELTGRLANLEEKEKDMLDFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9HQB5</accession>
    <name>E9HQB5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_263723</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732717">
        <property type="protein sequence ID" value="EFX66070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66070">
        <property type="protein sequence ID" value="EFX66070"/>
        <property type="gene ID" value="DAPPUDRAFT_263723"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_263723"/>
    <dbReference type="HOGENOM" id="CLU_724149_0_0_1"/>
    <dbReference type="InParanoid" id="E9HQB5"/>
    <dbReference type="OrthoDB" id="1548094at2759"/>
    <dbReference type="PhylomeDB" id="E9HQB5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="SSF57756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX66070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="382" mass="43781" checksum="73B3F98535D26738" modified="2011-04-05" version="1">MLAEEKEKEEEARVAAVGRDQQADRNSEDPTIKQLLEVGKTQQTGWTATKSWRTTTDADKRTNFGIYLEGPARQWFQCLTPPNDWGDTAAVAATQQQAATPAISGMRSIFIREFLQDSYAGYQESRLRKRKQGINEPAAEYYYEIINLCRLMDLNMSEEAKLHHLYEGLKPTLVEKIWVLQPKTCADFLAAVRRHTEAGELACNKGWAVHMLAEEKEKEEEARVAAVGRDQQADRNNEDPTIKQLLEVVQQLQGEIVSMKKQGRRRERSRADSRTTANQRWTTSPTRKDSRWAPICFYCKDEGHIKRYCQKKKNDDEIQNNTTVAMISTSDEENHQEIPLLQIDVGQLLLEEVTIGKNTPTKKAEAEQPCQSYPQNLPLRWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HRG8</accession>
    <name>E9HRG8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_264380</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732736">
        <property type="protein sequence ID" value="EFX65663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65663">
        <property type="protein sequence ID" value="EFX65663"/>
        <property type="gene ID" value="DAPPUDRAFT_264380"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_264380"/>
    <dbReference type="HOGENOM" id="CLU_2500176_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX65663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="86" mass="9551" checksum="627E5EF876E8A66C" modified="2011-04-05" version="1">MFHHILFMKPNSDSNTQIPIKHHFVDSFSQRVARLLYRTSYCFAVVFLAFSAGAEVATNVSSTSHSPALEEGIDLVSTSATSHTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HRT5</accession>
    <name>E9HRT5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_117185</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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        </source>
    </evidence>
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    </evidence>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Manak J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
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    <organism evidence="3">
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Yamagata H."/>
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                <person name="Crease T.J."/>
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                <person name="Robertson H.M."/>
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                <person name="Zdobnov E.M."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63671">
        <property type="protein sequence ID" value="EFX63671"/>
        <property type="gene ID" value="DAPPUDRAFT_267990"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_267990"/>
    <dbReference type="HOGENOM" id="CLU_970643_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HX62"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="329" mass="37272" checksum="E0BBFB751965C8ED" modified="2011-04-05" version="1">MSKARGPIPSTFTNRNIPLVKLNEISTYSQKIRFIGRVVYVSPLIRNLTGKKTTMLRMVLKDETKEIFGICYAKMANDWAKDLYMDAVYEFQLIQSSSTDFKIVSEYNEQLRINFNFDAKKIRNLNPAINIPDMEYTKLASVWEDGSQQTFLNIIGQLVSCLDPVGPDPEAGYDNIQQDYVIKDATKQVAMTIKGDMLFKKLKFFQSRTSKEPVIIRITRANPISDDEGEFLFVDEQESNVEVLLQSSTLYKTFTGDGDSSQNKKKQKVASSDIKSSLARTRQNKEEQSPSTSREFRCGQLLSTNKCYTASVGPTGKLTSEVVFVLITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9HYH7</accession>
    <name>E9HYH7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_119424</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733164">
        <property type="protein sequence ID" value="EFX63204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX63204"/>
    <dbReference type="EnsemblMetazoa" id="EFX63204">
        <property type="protein sequence ID" value="EFX63204"/>
        <property type="gene ID" value="DAPPUDRAFT_119424"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_119424"/>
    <dbReference type="eggNOG" id="KOG0596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_519020_0_0_1"/>
    <dbReference type="InParanoid" id="E9HYH7"/>
    <dbReference type="OrthoDB" id="172948at2759"/>
    <dbReference type="PhylomeDB" id="E9HYH7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006996">
        <property type="term" value="P:organelle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018105">
        <property type="term" value="P:peptidyl-serine phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027084">
        <property type="entry name" value="Prot_kin_Mps1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="PTHR22974:SF21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012971779" description="Protein kinase domain-containing protein" evidence="6">
        <location>
            <begin position="16"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="185"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX63204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="525" mass="58824" checksum="BA9295A3757DD2A1" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9I077</accession>
    <name>E9I077_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_336720</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL733487">
        <property type="protein sequence ID" value="EFX62605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX62605"/>
    <dbReference type="EnsemblMetazoa" id="EFX62605">
        <property type="protein sequence ID" value="EFX62605"/>
        <property type="gene ID" value="DAPPUDRAFT_336720"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_336720"/>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1311232_0_0_1"/>
    <dbReference type="InParanoid" id="E9I077"/>
    <dbReference type="OMA" id="INVAYTH"/>
    <dbReference type="OrthoDB" id="46968at2759"/>
    <dbReference type="PhylomeDB" id="E9I077"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="SSF57535"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="3">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="3">
        <location>
            <begin position="65"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="3">
        <location>
            <begin position="123"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX62605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="210" mass="22809" checksum="2051121E175510E8" modified="2011-04-05" version="1">MPVCVTRSCGDPPNIDNGFAVVRGTGVGDTISYSCQTGHRLSGVESRTCLSNGRCSGEDPACDPVVCAVPEAPEDGSWTVDGFVPGSTIRFECKLGFTLVGSATVTCLTDKSWSDRTPSCQQITCPPLRDPEHGTVQLTNWISDNQELNNDINQQLAVGYHSTAHYTCNRGYQLFGPGQRTCTDQGTWSDRGPQYRRVWCPEPQAPCKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9I1U6</accession>
    <name>E9I1U6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_337579</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733880">
        <property type="protein sequence ID" value="EFX62035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62035">
        <property type="protein sequence ID" value="EFX62035"/>
        <property type="gene ID" value="DAPPUDRAFT_337579"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_337579"/>
    <dbReference type="HOGENOM" id="CLU_1176465_0_0_1"/>
    <dbReference type="InParanoid" id="E9I1U6"/>
    <dbReference type="OrthoDB" id="1337075at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012361669" description="RING-type domain-containing protein" evidence="5">
        <location>
            <begin position="16"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX62035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="236" mass="26857" checksum="4E919BF7E0B0C9BD" modified="2011-04-05" version="1">MVVWLVAFNCGPTLSLLASRDTETDAKLQNIKRTTYGLLEYSYSMGGTCDELDIQFKQIMSGKSNSNASMNMSCDDEEFVSCQICFMNFDETERVPKYLEKCYHYFCLPCLGTKLTIWQKESSLSCLQVVETQTKASETQVEQLWSTECNSSVSVACQLSKHKTLTTLKHTSEFSHRNATNNILIAQVESLKSSEEFSILMEEDMVKTLKTIDELRVKFSSRTEDVKATESKFFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9I3K7</accession>
    <name>E9I3K7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_273548</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734614">
        <property type="protein sequence ID" value="EFX61423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61423">
        <property type="protein sequence ID" value="EFX61423"/>
        <property type="gene ID" value="DAPPUDRAFT_273548"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_273548"/>
    <dbReference type="HOGENOM" id="CLU_2471340_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX61423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="88" mass="10186" checksum="0EE69826579575C7" modified="2011-04-05" version="1">MWNKAANDRDRFHQQEHRDKWKDNPAAALGHCGAIAFQKFDPQLPQRCSYGTRLPSAESIPKWVDFIREAGKKDIKVYIIGNKCDLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9I3R2</accession>
    <name>E9I3R2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotran_1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_69782</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734698">
        <property type="protein sequence ID" value="EFX61368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX61368"/>
    <dbReference type="EnsemblMetazoa" id="EFX61368">
        <property type="protein sequence ID" value="EFX61368"/>
        <property type="gene ID" value="DAPPUDRAFT_69782"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_69782"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154456_0_0_1"/>
    <dbReference type="InParanoid" id="E9I3R2"/>
    <dbReference type="OrthoDB" id="1643066at2759"/>
    <dbReference type="PhylomeDB" id="E9I3R2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX61368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="127" mass="13564" checksum="4C256F6F6EE761CD" modified="2011-04-05" version="1" fragment="single">MTTTARFVPESKLPEVGTTIFSVMSALAADKKAVNLGQGFPDFSCDPALPTMVTQAMADNYNQYPPMPGMPQLREQIAAKIKSIYGHAYDVNTEITVTAGATQGILTVLLACVHAGDEVIVIEPAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9I3U4</accession>
    <name>E9I3U4_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_340092</name>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL734749">
        <property type="protein sequence ID" value="EFX61336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX61336"/>
    <dbReference type="EnsemblMetazoa" id="EFX61336">
        <property type="protein sequence ID" value="EFX61336"/>
        <property type="gene ID" value="DAPPUDRAFT_340092"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_340092"/>
    <dbReference type="eggNOG" id="KOG4422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:rRNA binding"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="PTCD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276">
        <property type="entry name" value="PTHR16276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX61336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="176" mass="20481" checksum="BD88F0469861CBB6" modified="2011-04-05" version="1" fragment="single">MLPLLHELLXSQKIYALSKESGIKAARLMIEKYPAAFYKDKCEPHVPKFYPNKLFTEQELKYPSEDLIYSLVDWGKFNLAFETYAKCKDQKIPVTESCKMVLLDCFSIYNGDDFQPMESMREKWFHKSIQEDRGDLRNSYIQKSTWKKKGPAEIIFADLKVKPASAYCSLIKGMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9I3Z5</accession>
    <name>E9I3Z5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_122336</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX61284"/>
        <property type="gene ID" value="DAPPUDRAFT_122336"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_122336"/>
    <dbReference type="HOGENOM" id="CLU_052726_1_0_1"/>
    <dbReference type="InParanoid" id="E9I3Z5"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="PhylomeDB" id="E9I3Z5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX61284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="241" mass="25466" checksum="0EB4CD27574A9C3F" modified="2011-04-05" version="1">MFADGKSLWESLAAIRSTPVSPTLPAPRELSTRQSQAAFVQAASPNTRASSLRIGQPVRALIGRRWLHGKVHSVFPEPQSYVVRLDDGHYFRRTRWAINVDRGTQSQPRSRDSTAMFSYRVPTIVQSAQSATGCETSGPASGVAGSPVIEAPTPVRVGVPSSAEPATPSGRQSSNIGRVRTAASHGARQVRLFDAPLSPSVAPPPMSAGPSGDSGAAPAREPFGTTRSGVRFGIAMPSTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9I4T3</accession>
    <name>E9I4T3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX60997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1943393_0_0_1"/>
    <dbReference type="OrthoDB" id="1230328at2759"/>
    <dbReference type="PhylomeDB" id="E9I4T3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX60997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="130" mass="14929" checksum="A843FDAE1AD2FD33" modified="2011-04-05" version="1" fragment="single">KTTKETAHKAFWYLLKEEDPPKYEKALTLLEEIKEVVWQDYAVMRYSIAACSVEYERNGFRHTREWLHCNRKETSQHSVSSSNAITSVKRSANGRMEVGCANVQATLVLLFLAIYCYAYVVGGHDGQSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9I4Y2</accession>
    <name>E9I4Y2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_274945</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
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                <person name="Hatcher P."/>
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                <person name="Skalitzky C."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Wolf Y.I."/>
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                <person name="Bork P."/>
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                <person name="Zdobnov E.M."/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Robertson H.M."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX59927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="100" mass="11367" checksum="F69655A6C1988F1F" modified="2011-04-05" version="1">MLGNFDPIDQKLVTVKWLKILGLFDATRLSETSSTNYRLAVALGVQVLQHLHPVWMSDALAVSERKAHPKNCHFQRVNPFDKETIIEYVGVLFARWVCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9I7V9</accession>
    <name>E9I7V9_DAPPU</name>
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        <recommendedName>
            <fullName evidence="1">Abhydrolase_3 domain-containing protein</fullName>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX59921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_346397"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_346397"/>
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        <property type="project" value="InterPro"/>
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            <begin position="149"/>
            <end position="193"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="296" mass="32496" checksum="BCD9A5A025F285CC" modified="2011-04-05" version="1">MKYDDFKNQVKVTRDVIFGEAVIDYHGIPKKRPLLLDVYEPEAKNRNGTCSPAIITIFGGAFHFGNKEDDSFTAGETFNTSASAYASYWATRGFVTFSVGYRLTSEDPAPGSTPALASHDSIAPDRMHRAREVLGLPPASLHELACGIEAAADDVAMATRFVQDNADRWNVDPTRVALFGWSAGGRSALNAVFAEGVDVKAVVAASAFLHSDDLRANVPFIRQSPSLMVVTAERDLPHIVEQGSIVPDYLRKRLPIVESVSVPEVDHFYPASSVVYQDKKQSTLLEVITQFFERNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
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    <name>E9FQX6_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="common">Water flea</name>
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        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX90291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_299902"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299902"/>
    <dbReference type="eggNOG" id="ENOG502R1K6">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_059624_0_0_1"/>
    <dbReference type="InParanoid" id="E9FQX6"/>
    <dbReference type="OMA" id="IYRYHEQ"/>
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    <dbReference type="PhylomeDB" id="E9FQX6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    </dbReference>
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        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX90291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="405" mass="46969" checksum="D9CB21FFDB75E4C3" modified="2011-04-05" version="1">MMQNITSYLVRASSQSTFTQLRFQGLRSLYTAEALGLDGYATSRSKTAVNFHGTQMKEKFRTRMQEFVGSSSSNLIFTDDLKTMVNLAENTPEDIQLLEQMIEKFHSQSTGLRFGTFVFGPVIMRFLYSINETKALLSLLRNPKTVTLFDQFISYQIAMDLLLENKMYKEVLEVFDIAQKRNIQDNQYPKNCFIIVMAALCRQNTPESYQEMKTLLTKASSFGHIPMRRALTYAASLALKQNDPKFCMELLSECKQQNYVTVRNLKAVALAKLDRFDDCVAVLRAALEYDRPAGVEFRKRNFFKDVIDTIDQEIKGTASKDVQLEYDRVVKTLRDRDMIEDQILDSILDHPIDRVDPRERDNWGSNDRSFVDRGMVKRNFNKDNQYERNARPLYPPRRPGLNEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9FR01</accession>
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        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX90073.1"/>
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    <dbReference type="EnsemblMetazoa" id="EFX90073">
        <property type="protein sequence ID" value="EFX90073"/>
        <property type="gene ID" value="DAPPUDRAFT_309859"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG4257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:focal adhesion"/>
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        <property type="project" value="InterPro"/>
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            <end position="150"/>
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    </feature>
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            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="165" mass="18932" checksum="939DEF98AB2BA2EB" modified="2011-04-05" version="1">MEQERRMLEWKLRQQQRQSEEDSRWLAEEESHLRKRLSVAASSSDRSDTDSMDGANAYQKDRSTPLQGNQLDHQSVVVKNLEPKPTARLDRTHDKVYDATTSVVRAVMLLSQGVQQAKIXNYVDLVKKVGLELRTLLTSVDQLVPHFPPVLIEKVLFLFLLPNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRM7</accession>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX89877.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_957304_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <location>
            <begin position="1"/>
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    </feature>
    <feature type="chain" id="PRO_5003236307" evidence="2">
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        </location>
    </feature>
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            <end position="210"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX89877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="332" mass="36396" checksum="58707C01FE2B6090" modified="2011-04-05" version="1">MAPLSRNGLLYLFLAASMAVTCYAAAAADPAVDSKPALQNFAEPAEKVKSRDSHALKSDVSYTNYLKAPQIQPPTPVALSGSAAGVSFPSIAQPPAQPAVQSAVHPASHSIPVPALYSNPQETTMGYVYYYLPQVAEKYYPKLKDLMPYVKHYGYAASRAWQNMPSMRQMADRTFDITSAIGLVLLAPVMLISSVLFLGFIVILFFFPAVSAFGRRRMGRDLSAVEDLNEVLDFDRFLPLEQSRTLASLAARVDDVLDNYMRAFKSDTCLEKFSCQAGQMTSRLGKLTEPIITLLEPLVPAYMYKKLEAFKNGARSGSADCSEMKCKLPFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9FS35</accession>
    <name>E9FS35_DAPPU</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
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                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DAPPUDRAFT_220028"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_220028"/>
    <dbReference type="HOGENOM" id="CLU_546609_0_0_1"/>
    <dbReference type="OrthoDB" id="1503014at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF4786"/>
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    <dbReference type="Pfam" id="PF16027">
        <property type="entry name" value="DUF4786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX90387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="499" mass="54949" checksum="C51C4A4C1B9AD84E" modified="2011-04-05" version="1">MLFTARSWALSYMQVNSSWLVYMHPFTHSILCRVITPIHGRCIQVAALLQVKRRIKPIEMLVLMIQELTGVNISGELKGKKLHDSLDFGCRLVAGQGRSLEADTSGRCADYQIPLRLLLAVAVVCLATGIESRAQFSNMRVFRTNGMFNKDHWRPMDILKSFKINKEQETDSSRAAEIVSASSIKRVSMASLLQQLNQVSSGKKDVFFPTPIATKQEESSSLSIPVTIIESNHSAITPVVKESTIRRVKLPAGSISYSRNGPASNGPSILLNINPHLQRSTKFPSTEPPTTTEPATTTTTTTEPSTTTEPSTTTTEPSTSTATEPCVTKVYVKAKPIEQQAAKPYGQNKAKTPASVRADNILASSKKLSQMPNSPIYYIKLPASSFVSGRTPHKEDAVPFDFFKQSPIFVATTRRPSNGGSNVVEEITTTEVPSETLLSTTTRSPPRTNSRVINIKGPFVFNGKPGGIYSAPAPYRPPNYLDLLHQLYPKLKRAQFIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUP5</accession>
    <name>E9FUP5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_220992</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88888">
        <property type="protein sequence ID" value="EFX88888"/>
        <property type="gene ID" value="DAPPUDRAFT_220992"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_220992"/>
    <dbReference type="eggNOG" id="ENOG502QWMD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107303_0_0_1"/>
    <dbReference type="InParanoid" id="E9FUP5"/>
    <dbReference type="OrthoDB" id="1174178at2759"/>
    <dbReference type="PhylomeDB" id="E9FUP5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="SSF57625"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236821" evidence="1">
        <location>
            <begin position="22"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="40"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="167"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX88888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="225" mass="24252" checksum="BC2933BEB2DE820F" modified="2011-04-05" version="1">MNSKVLASLVAFCGLMAIVAGASNSKLQIEARDTDLGESDYQCPEGLYVAPHETQCELYYICASGGTPTHLYQCRDDLLFDLEYYGCNFKEMVDCGDLLAPFTCPSPNGKFPVKEGACDSRYYICTDGVSDLQTCPNGGIFDATASSCVATPCATTTTVAVPTAPGPFECPAPNGYFPSPYSCSQYYVCLEDKPYLYTCPAGLYYNPALEACDWPANVNCNLPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9FVM3</accession>
    <name>E9FVM3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_233754</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX89079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89079">
        <property type="protein sequence ID" value="EFX89079"/>
        <property type="gene ID" value="DAPPUDRAFT_233754"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_233754"/>
    <dbReference type="HOGENOM" id="CLU_1715102_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="153" mass="16611" checksum="071BD37C8C715E42" modified="2011-04-05" version="1">MEDISVLKQRLGSLLAITALLGGGHTSAASPDRIQSMGNEEVAVEISGKWETPNDVGGGGVDISYAIRNAERAHISPRGKGEEIKKRTLTLAGSQQQQQQLDDNNGMAFDSPNRQRGVKELVNQNKESKVPSEKELDRRGGEKDTEKQEEGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXY6</accession>
    <name>E9FXY6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_305733</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88211"/>
    <dbReference type="EnsemblMetazoa" id="EFX88211">
        <property type="protein sequence ID" value="EFX88211"/>
        <property type="gene ID" value="DAPPUDRAFT_305733"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305733"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027428_1_1_1"/>
    <dbReference type="InParanoid" id="E9FXY6"/>
    <dbReference type="OMA" id="TFQEPRK"/>
    <dbReference type="OrthoDB" id="849206at2759"/>
    <dbReference type="PhylomeDB" id="E9FXY6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="SSF48065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="174"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX88211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="602" mass="67263" checksum="C6F936FFE3FBCE30" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9G0X0</accession>
    <name>E9G0X0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_97182</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87330"/>
    <dbReference type="EnsemblMetazoa" id="EFX87330">
        <property type="protein sequence ID" value="EFX87330"/>
        <property type="gene ID" value="DAPPUDRAFT_97182"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_97182"/>
    <dbReference type="eggNOG" id="ENOG502QPQ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_6_0_1"/>
    <dbReference type="InParanoid" id="E9G0X0"/>
    <dbReference type="OMA" id="FCEIKRK"/>
    <dbReference type="OrthoDB" id="1425837at2759"/>
    <dbReference type="PhylomeDB" id="E9G0X0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP43_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="107"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="193"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX87330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="266" mass="30149" checksum="B3584978226A75AE" modified="2011-04-05" version="1">MSCSYIQVAEDETEEPIELPTEDDSALLLSTLAAQFPGVSGLKYRAPESRSMRGVRLLEGRFQPPEDGWGNHVYICVFPKENKRKSDDHPENSTAKTKRMEMRLKCSDLIVLGLPWKTSEQDLRVYFENFGELLMAQVKKDAKTGQSKGFGFIRFANYDSQVRVLSQRHLIDGRWCDVKIPNSKAGGTPQVPCKVFVGRCTEDITADDLRDYFCKFGEVTDVFIPKPFRAFSFVTFLDPEVAQSLCGEDHIIKGSRCALEQVRRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1H3</accession>
    <name>E9G1H3_DAPPU</name>
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        <recommendedName>
            <fullName evidence="7">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_44337</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetylcholine + H2O = acetate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="GL732529">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86815"/>
    <dbReference type="ESTHER" id="dapul-ACHE2">
        <property type="family name" value="AChE"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86815">
        <property type="protein sequence ID" value="EFX86815"/>
        <property type="gene ID" value="DAPPUDRAFT_44337"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_44337"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_13_0_1"/>
    <dbReference type="InParanoid" id="E9G1H3"/>
    <dbReference type="OMA" id="NQMVGDY"/>
    <dbReference type="OrthoDB" id="754103at2759"/>
    <dbReference type="PhylomeDB" id="E9G1H3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="COesterase" evidence="9">
        <location>
            <begin position="68"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX86815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="621" mass="70207" checksum="3EAB834F10DA90E6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9G2R6</accession>
    <name>E9G2R6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EOG090X0CWA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EOG090X0CWA</name>
        <name evidence="3" type="ORF">DAPPUDRAFT_222073</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TCO</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL732530">
        <property type="protein sequence ID" value="EFX86465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015496">
        <property type="protein sequence ID" value="SVE85115.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86465"/>
    <dbReference type="EnsemblMetazoa" id="EFX86465">
        <property type="protein sequence ID" value="EFX86465"/>
        <property type="gene ID" value="DAPPUDRAFT_222073"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_222073"/>
    <dbReference type="eggNOG" id="KOG1612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_4_2_1"/>
    <dbReference type="OMA" id="PESVFEM"/>
    <dbReference type="OrthoDB" id="965225at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043928">
        <property type="term" value="P:exonucleolytic catabolism of deadenylated mRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071042">
        <property type="term" value="P:nuclear polyadenylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:nuclear polyadenylation-dependent tRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034427">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="1">
        <location>
            <begin position="32"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="2">
        <location>
            <begin position="197"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX86465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="SVE85115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="290" mass="31507" checksum="2A525A2E92BD28C2" modified="2011-04-05" version="1">MAEILLSEAEKAFIHHGVQDDLRCDGRTRLDYRPIILETGLVSNASGSARLRLANSDILVGVKVELASPLPDKPQEGRLEFFVDCSANATPEFEGRGGEDLANEICRFLQRSYASGDTINLSELSVLTGQQCWVLYVDILILECGGNLYDAVSLAVKSALYATQIPSIKVATMDGDQPELELSDDPYDTKRLNTENIPCVVTLMKIGNHYLVDPTPEEECCSSSGIVVAVSGNKKITAVRKIGSGSLHPDSLVSMLKTGSEVGAVVNTILMKKLLEEETLELSQKVGFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9G471</accession>
    <name>E9G471_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase-like protein A2, group</fullName>
            <ecNumber evidence="4">3.1.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PLA2G12A</name>
        <name evidence="4" type="ORF">DAPPUDRAFT_98240</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="4"/>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX86063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86063"/>
    <dbReference type="EnsemblMetazoa" id="EFX86063">
        <property type="protein sequence ID" value="EFX86063"/>
        <property type="gene ID" value="DAPPUDRAFT_98240"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_98240"/>
    <dbReference type="eggNOG" id="ENOG502QU22">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093969_0_0_1"/>
    <dbReference type="InParanoid" id="E9G471"/>
    <dbReference type="OMA" id="KNGICQY"/>
    <dbReference type="OrthoDB" id="1299904at2759"/>
    <dbReference type="PhylomeDB" id="E9G471"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonic acid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010711">
        <property type="entry name" value="PLA2G12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLipase_A2_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12824">
        <property type="entry name" value="PTHR12824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06951">
        <property type="entry name" value="PLA2G12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="SSF48619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236639" evidence="3">
        <location>
            <begin position="20"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX86063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="196" mass="22253" checksum="77F97EEF6368E3FC" modified="2011-04-05" version="1">MSSLPRVIRILLVFVTISALFVDGQKSYFDEIKDAMHNLKSFLHTGLDGLSKLAKTIQVVEQFVDATIDEDCEPYTCPKGFIRKANPLHIPESNGCGSFGYTWKEEKLPLKELEECCHTHDYCYDDCGADKDLCDLHFKKCLYKVCSNHEEELSLLFMKACKGTAKLMYTGTLALGCQAYREAQNKACQCYARDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G626</accession>
    <name>E9G626_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_238303</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX84865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84865">
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        <property type="gene ID" value="DAPPUDRAFT_238303"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238303"/>
    <dbReference type="HOGENOM" id="CLU_2006151_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="EFX84865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="124" mass="14135" checksum="907D7ABEF771ED59" modified="2011-04-05" version="1">MVPSFRFKVLESLDRGPNHSAEEIVVLLSLGGFGTTTYTSRNNSPIHSHHLGIQQRKPSLLGQIFQCRAKLYRCSPFDIEATAHIRAGYLVRCDGSSTVDYILFMCYYVNEFSVLIRQMQTWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9G683</accession>
    <name>E9G683_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_238370</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX85036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85036">
        <property type="protein sequence ID" value="EFX85036"/>
        <property type="gene ID" value="DAPPUDRAFT_238370"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238370"/>
    <dbReference type="HOGENOM" id="CLU_2374863_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX85036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="95" mass="10302" checksum="57280F47E8422D24" modified="2011-04-05" version="1">MERSAYCIEYLAIHFLHWTDRNRWEEKKGKSRFIVSNAFSGSESSSEDGRKSLDAGVMEMQPVLFGKSVFASDGRAVSTSAAPGGPSTPTNIGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6A6</accession>
    <name>E9G6A6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_194189</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX84900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84900"/>
    <dbReference type="EnsemblMetazoa" id="EFX84900">
        <property type="protein sequence ID" value="EFX84900"/>
        <property type="gene ID" value="DAPPUDRAFT_194189"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_194189"/>
    <dbReference type="eggNOG" id="KOG1514">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012774_5_1_1"/>
    <dbReference type="InParanoid" id="E9G6A6"/>
    <dbReference type="OMA" id="QPIINGE"/>
    <dbReference type="OrthoDB" id="935804at2759"/>
    <dbReference type="PhylomeDB" id="E9G6A6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041083">
        <property type="entry name" value="AAA_lid_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020793">
        <property type="entry name" value="ORC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="PTHR10763:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17872">
        <property type="entry name" value="AAA_lid_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="91"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX84900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="439" mass="49034" checksum="00DBABA8115F2655" modified="2011-04-05" version="1">MIILFLKVVEEKTPKKPKRTGSATPGSTQKKRLRLTPAISSRSCKVADPTSPLGEIRRRLHVAAVPQTLPCREDEFNQIFSYVEGKLSDGIGGCMYISGVPGTGKTATVNEVIRMLRESQTEGDLPDFKLIEVNGMKLTAPQQIYVQIWDQLTGSKVTADKAAKLLHAKFSTNGPRHRPTVLIVDELDLLWTRQQDVLYNIFEWPNRPKAQLTVLAIANTMDLPERLLMNRVSSRMGLTRLTFQPYKVKQLQTIISSRLENLVSFEPEAVEFIARKVSAASGDARRALDISRRAAELAEKGGHTNSSPTKSPSKRGAQSSRSTVMMQHVQTAIEEMFSSPKLLAIQACSLHEQLFLNALVQEFNRTGVEESFFDQVIRQHYTLCDLEGMSRPNVSELLSVCASLCSSRLILSEHGRNDIRQKVRLNIGIDDVTYALKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8G6</accession>
    <name>E9G8G6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EOG090X0BKO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">EOG090X0BKO</name>
        <name evidence="2" type="ORF">DAPPUDRAFT_223051</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TCO</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX83970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015456">
        <property type="protein sequence ID" value="SVE85075.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83970"/>
    <dbReference type="EnsemblMetazoa" id="EFX83970">
        <property type="protein sequence ID" value="EFX83970"/>
        <property type="gene ID" value="DAPPUDRAFT_223051"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_223051"/>
    <dbReference type="eggNOG" id="ENOG502QW4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103794_1_0_1"/>
    <dbReference type="OMA" id="DEFRGHC"/>
    <dbReference type="OrthoDB" id="1596832at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029673">
        <property type="entry name" value="TMEM179"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31872">
        <property type="entry name" value="PTHR31872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SVE85075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="222" mass="24675" checksum="362553A411454198" modified="2011-04-05" version="1">MNVLLVIQITVYILALVLALCISVPVIIHQKDFKGHCLLFSRGTWRETDGQFVITWAPNAYCVFVILSGVISLTACCIQIHRLGHFLYRGLDSSFLSAFVDAVGSAFLCFLSLASAMIITLGFGTWCGDITQRFEECSYAEDENIDQVDNINTSGFYLLLGTAQFGAWASWACWVGLAVCAVLKLCRYHQRENIRVSMAKERRRLLTDGLPPRSSSDEAMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8M1</accession>
    <name>E9G8M1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_47474</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84242"/>
    <dbReference type="EnsemblMetazoa" id="EFX84242">
        <property type="protein sequence ID" value="EFX84242"/>
        <property type="gene ID" value="DAPPUDRAFT_47474"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_47474"/>
    <dbReference type="eggNOG" id="KOG0804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009969_3_0_1"/>
    <dbReference type="InParanoid" id="E9G8M1"/>
    <dbReference type="OMA" id="GIIHLYK"/>
    <dbReference type="OrthoDB" id="659103at2759"/>
    <dbReference type="PhylomeDB" id="E9G8M1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12718">
        <property type="entry name" value="RRM_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034932">
        <property type="entry name" value="BRAP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="214"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="265"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="380"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX84242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="530" mass="59816" checksum="84F779FAD78EDD7F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9G989</accession>
    <name>E9G989_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_315266</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84098"/>
    <dbReference type="EnsemblMetazoa" id="EFX84098">
        <property type="protein sequence ID" value="EFX84098"/>
        <property type="gene ID" value="DAPPUDRAFT_315266"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315266"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_3_1_1"/>
    <dbReference type="InParanoid" id="E9G989"/>
    <dbReference type="OrthoDB" id="1289629at2759"/>
    <dbReference type="PhylomeDB" id="E9G989"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013334064" description="GH18 domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="24"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX84098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="404" mass="44836" checksum="57E05926627D50DE" modified="2011-04-05" version="1">MKIIFLALLLAVADCITETGGTSQRLVCYLNVQATNRTGDGAFSLENIDPYLCTHLIYAFTSDIALNSTSFGPTQIAYDKLLAPRVKNPKLKIMASIKSEDLKWDSSKGIENKVNKTVDYLKKYRLDGLDIYWNMSSGNYPIVNFFTAMRNAFDRHNLIFSLAVFTETNNDVMYFMDFVDTVDFISVLAYDLWRSTQAFWEANHPAPLYSNSSDGRTIDSLILYWLEHDTPAAKLNLGIPLYGSSWTILADGKTEPPASATWGPLNKHVNQIGQTPYYDICSSVKSSGWKVFEEKSNSTGPYAVSPADPSGSRVWVGYDDVHMVTVKSQYVRYVRGLGGATVWDLSQDDCRNVCGKGSYQLTAAISRTLGIPRPKSSSSASDSKQSSLSNVIFLIFTSGLLSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9G993</accession>
    <name>E9G993_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_223182</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84126">
        <property type="protein sequence ID" value="EFX84126"/>
        <property type="gene ID" value="DAPPUDRAFT_223182"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_223182"/>
    <dbReference type="eggNOG" id="ENOG502S4KI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075165_4_0_1"/>
    <dbReference type="InParanoid" id="E9G993"/>
    <dbReference type="OrthoDB" id="1583175at2759"/>
    <dbReference type="PhylomeDB" id="E9G993"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012203851" evidence="3">
        <location>
            <begin position="16"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX84126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="194" mass="21373" checksum="C1A3CB463C80C411" modified="2011-04-05" version="1">MKFFILAALFAVAAADSYRSAEYAPKYEAPAYKSTYEAKYETPQPYDFSWAVNDYYNDYEHSEKSVDGNVVTGSYRVVLPDGRTQIVTYRADSYGYVADVKYTGEAKYPEYVANNYKATTYSAPAYKPTAPTYSAPAYKPTAPTYSAPAYTAPTYTAPAKKGPTYTVTAPTYSAPAPAYTATPVYKAPAVQPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9Z7</accession>
    <name>E9G9Z7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_100286</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83655">
        <property type="protein sequence ID" value="EFX83655"/>
        <property type="gene ID" value="DAPPUDRAFT_100286"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_100286"/>
    <dbReference type="HOGENOM" id="CLU_022778_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9G9Z7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="480" mass="54315" checksum="4BB14BC740073795" modified="2011-04-05" version="1">MSRYRPSPSESFDGQFFDPRVGFFDQPRLERERMRDNELRSRPHHQHPNYQVRDRSPVDFPRFAPRWDDYNRDAPRPEGFGFVAPYDDRFVRDDQPSSSRRGRERMQMRYQFEQDGFYYDTETGYRHDSGGFLCDENGVRLNRAELESYEQSVRFAHPIASVIGPIPPRTEDEPIDIDIEDQEEQDDSRRGVQAVTAPLEGLSLPGSSGAQPLSVPKSISDEILLFMTSGISTDSSKAISKEFCLDYVDVKPPKLDGWISRRVLLKSDKNLIKSINAKEETLIKAQLKIMDIGQPLVDLYTRLSSLPDNETIKRPVQAALQQWGRAYFSITRERRSAVVALAEPSADYLLKEPDAFDTGKEARVFLLTDKFLQVMLNNANQDNTLAQASKAAAAAAAANATRRPATRRVRAEPPSSSSHPPPRYESDVIVRGGRGGRSRRAGHGRGQRSVTWFPGSRRYVTSKSNSLTPCKIFPSPDSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9GA80</accession>
    <name>E9GA80_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX83695">
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        <property type="gene ID" value="DAPPUDRAFT_315602"/>
    </dbReference>
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        <property type="term" value="P:acetylcholine biosynthetic process"/>
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        <property type="project" value="GO_Central"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX83731">
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    </evidence>
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    </evidence>
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</entry>
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    <accession>E9GBH2</accession>
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        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732538">
        <property type="protein sequence ID" value="EFX82957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82957">
        <property type="protein sequence ID" value="EFX82957"/>
        <property type="gene ID" value="DAPPUDRAFT_316029"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_316029"/>
    <dbReference type="eggNOG" id="ENOG502SX7C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1367463_0_0_1"/>
    <dbReference type="OrthoDB" id="1387707at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="94"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX82957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="200" mass="23257" checksum="E7DF85378CCAAD0B" modified="2011-04-05" version="1">MYHFVKPIQVRRNVLHQDKLLLFLDAGVLQKLHPKFRVHFIIGSDYRPLDFGYLAGTTRYMGNRIKGSGYTSLHDLNYESVGYRDDYYTNEAYPQLVGQGQVRVNGQDAELTCQFPPTYDIVSNIVWEKLERNGVDSWALDRQDPRFSIRQQSAVGSRLVIGEYAARDEGVYRCIATRRDNSHFRQTRTVYQDIPFVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9GC42</accession>
    <name>E9GC42_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_315948</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732538">
        <property type="protein sequence ID" value="EFX83206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83206">
        <property type="protein sequence ID" value="EFX83206"/>
        <property type="gene ID" value="DAPPUDRAFT_315948"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315948"/>
    <dbReference type="eggNOG" id="ENOG502QVK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049233_0_0_1"/>
    <dbReference type="InParanoid" id="E9GC42"/>
    <dbReference type="OrthoDB" id="1243610at2759"/>
    <dbReference type="PhylomeDB" id="E9GC42"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="450" mass="51601" checksum="9F20FDFCA299BF6F" modified="2011-04-05" version="1">MITVAANVNLDTVCTEDDTKWSELVAPAPRGIAVLSQLMICTSHVTDFPIAKIDKEKIPLIQHPESFRTTLVQIVNDAYNAFMKAHTNMEKIQLQMAQVPDYVKDCVKIIKSDNKVAIEKFVPRRLEVIKEAADDGQKLSKEVCDAFDLLGQLIQQVLLAIAASQGAKEQEIEKLIKENIEAGNKRRNESIDRQKKYLQQEVEDNQQLKNRGQQYVMEEQKRSRDILERIFYPGEKEKKIKNFERSVEDAEKRLEKAKQDAKKADEEMGKIEKEFTESLKNMHIDVKNDISTDRMIKILTDGTQLLGKLQKNWVGMTMYFQSINSYIEKVMNKQQNIFVGDAQTAQENTFLIDFMADSIKKSLESSIKSNRTAATYVKVSSNYIMEPLRKMHGMLAIEPAKMDQAQKELVESCERASKGITIMFNEDREQTIREMENSLQSLDPCQSIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E9GC71</accession>
    <name>E9GC71_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bulb-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_316218</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732539">
        <property type="protein sequence ID" value="EFX82503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX82503"/>
    <dbReference type="MEROPS" id="M10.031"/>
    <dbReference type="EnsemblMetazoa" id="EFX82503">
        <property type="protein sequence ID" value="EFX82503"/>
        <property type="gene ID" value="DAPPUDRAFT_316218"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_316218"/>
    <dbReference type="eggNOG" id="KOG1565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495466_0_0_1"/>
    <dbReference type="InParanoid" id="E9GC71"/>
    <dbReference type="OrthoDB" id="1075463at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033595">
        <property type="entry name" value="Zmp-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF280">
        <property type="entry name" value="PTHR10201:SF280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="SSF51110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Bulb-type lectin" evidence="8">
        <location>
            <begin position="428"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="327"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX82503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="550" mass="61839" checksum="726A610A77C94CA9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GCA7</accession>
    <name>E9GCA7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_240702</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX82891">
        <property type="protein sequence ID" value="EFX82891"/>
        <property type="gene ID" value="DAPPUDRAFT_240702"/>
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    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_240702"/>
    <dbReference type="HOGENOM" id="CLU_3070782_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="EFX82891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="53" mass="6135" checksum="4800A90D5E122EC1" modified="2011-04-05" version="1">MPVFLINSIPFDWGKLPTKLRSSSSPFFNVLMYTHRDLHNNGKSTYLSLNVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9GCI0</accession>
    <name>E9GCI0_DAPPU</name>
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        <submittedName>
            <fullName evidence="7">Putative zinc finger protein</fullName>
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        <name evidence="7" type="ORF">DAPPUDRAFT_230733</name>
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    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Cladocera</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX82863">
        <property type="protein sequence ID" value="EFX82863"/>
        <property type="gene ID" value="DAPPUDRAFT_230733"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230733"/>
    <dbReference type="eggNOG" id="KOG4118">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176397_0_0_1"/>
    <dbReference type="InParanoid" id="E9GCI0"/>
    <dbReference type="OMA" id="EAKHPKD"/>
    <dbReference type="OrthoDB" id="1620202at2759"/>
    <dbReference type="PhylomeDB" id="E9GCI0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MBS1/2-like"/>
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        <property type="entry name" value="Uncharacterised_SERF_N"/>
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        <property type="entry name" value="ZNF706/At2g23090_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="79"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX82863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="79" mass="8691" checksum="22EC8DDAF2E50271" modified="2011-04-05" version="1">MARGQQKIQSQQKANEKAAKAKKQQGHSASDQKKAAMAALVHVCAVCKSQMPDPKTYKQHFENKHPKNPLPADLQDVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9GCU5</accession>
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        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Dynein-attachment factor required for cilia motility.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
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        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CCDC103/PR46b family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
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    </dbReference>
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        <property type="term" value="P:inner dynein arm assembly"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="CC103"/>
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        <property type="entry name" value="Dynein_attach_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28572">
        <property type="entry name" value="PTHR28572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15867">
        <property type="entry name" value="Dynein_attach_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein_attach_N" evidence="12">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP3_C" evidence="11">
        <location>
            <begin position="105"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX82618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="216" mass="24128" checksum="87FF9F193FEAFCCB" modified="2011-04-05" version="1" fragment="single">VSFAQMEKDLISALESDAHNQLENEAKLRAISQRVSYDEFRDIVRGVHLKPVPSGSLSVNKPQKGRIWNNIALSKKSYETEACEARKGTAATPANNYSLNQLPISAQFLNSWQQSDTKSRLLILYKIGPAGLNNIFTIDMPTALLGEIFEALLCFNPVTDVVAVIKLMEALTKIKRFNLIVHFLNASERATCQQLIHKLLASLVQREQDFAEEGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDK8</accession>
    <name>E9GDK8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_241167</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82099">
        <property type="protein sequence ID" value="EFX82099"/>
        <property type="gene ID" value="DAPPUDRAFT_241167"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241167"/>
    <dbReference type="HOGENOM" id="CLU_919071_0_0_1"/>
    <dbReference type="InParanoid" id="E9GDK8"/>
    <dbReference type="OrthoDB" id="1446732at2759"/>
    <dbReference type="PhylomeDB" id="E9GDK8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX82099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="303" mass="34172" checksum="118D467D8001B2F2" modified="2011-04-05" version="1">MASSDENVSDSDEDMISCHHYFCLSCIKSFSKPKCATCPTCRTSTDLTARKIERLTTNNIALRLVAISEDRARERQEHETVEKEIMDQQLWCSECNMSATNECHKKEHAILSYFDIYNSHSSLLKSVISETNAVCDRALEHHQKIYSTLLEMFAKVRWLESQIILRVESSKASISHLESLKSKEDFKEVPAEEDMVNTVNQMNQLIVQITERSDLAKAAELEACELLKTYGSNSSTFLISLLETEQCLPEGLGLGSNGDGVDKCGELNDLKKKYGLSKDENNMVEDEVVKSQDYTKPVTCSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9GE94</accession>
    <name>E9GE94_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_27434</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX82226"/>
    <dbReference type="EnsemblMetazoa" id="EFX82226">
        <property type="protein sequence ID" value="EFX82226"/>
        <property type="gene ID" value="DAPPUDRAFT_27434"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_27434"/>
    <dbReference type="eggNOG" id="KOG2287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036849_6_0_1"/>
    <dbReference type="InParanoid" id="E9GE94"/>
    <dbReference type="OMA" id="VTIKYIH"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="PhylomeDB" id="E9GE94"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX82226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="198" mass="22413" checksum="A39A03F4BDE8D4C5" modified="2011-04-05" version="1" fragment="single">DRSLLIVVISAPGNFLHRKLIRRTWVTHLNGIQYAFLVGSTDQSAVQQGIRNESSIYEDLIQVDMVDTYMNLTLKSVALLHWASQFCPDAPFIFKCDDDIYINIRNLAEVVQQLPPKIPRVYGTSVSNLKPLRPKELGSSSQPADDSDKWIIDRRLWPWSTYPTYVSGGCYLIDTSAIGPLLAAAQTTPYFPFEDLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEC2</accession>
    <name>E9GEC2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_101723</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82235">
        <property type="protein sequence ID" value="EFX82235"/>
        <property type="gene ID" value="DAPPUDRAFT_101723"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_101723"/>
    <dbReference type="HOGENOM" id="CLU_1054708_0_0_1"/>
    <dbReference type="InParanoid" id="E9GEC2"/>
    <dbReference type="OrthoDB" id="1216224at2759"/>
    <dbReference type="PhylomeDB" id="E9GEC2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX82235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="264" mass="29838" checksum="ABE0F0CFC19E90BB" modified="2011-04-05" version="1">MTTFGDAEDFATCGVCLYEYDEEIRKSKFQPCSLTFCLPVFRRNGRGTGPSSSLEFPLRYFTLSELMSLVEGSTSSDSVDTLKKKMKKSAEIYKQKLYEATAVASEYELRQKTKTMPGLFIILPKSHPQFQPVVRSMTKHGSTYHNCTAEDFDEVGITLVKNSAKGKIIGWSFVFVLEEHEHFQECANHLPKPVWDKEYFGDVIYHEGLIAAVILLSKVSKKIPNEKCNAVKYILANQFSNKKASIKLEYSGVASRSVGYMTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEJ9</accession>
    <name>E9GEJ9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gb3_synth domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_49182</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX82277"/>
    <dbReference type="EnsemblMetazoa" id="EFX82277">
        <property type="protein sequence ID" value="EFX82277"/>
        <property type="gene ID" value="DAPPUDRAFT_49182"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_49182"/>
    <dbReference type="eggNOG" id="KOG1928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049512_1_0_1"/>
    <dbReference type="InParanoid" id="E9GEJ9"/>
    <dbReference type="OrthoDB" id="1082380at2759"/>
    <dbReference type="PhylomeDB" id="E9GEJ9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007652">
        <property type="entry name" value="A1-4-GlycosylTfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04572">
        <property type="entry name" value="Gb3_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gb3_synth" evidence="3">
        <location>
            <begin position="126"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX82277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="271" mass="31245" checksum="2595FB7C887C6043" modified="2011-04-05" version="1">MDDHVAGHQQQQKQKQQIKNKSKNKVLLAKTVQQLKEKYRNNIQFATVSLDEFIAGSLLEKWYHCTDWRKGPYHVSHLSDGLRFLTLNKYGGYYFDLDVLMVRPVTYYSNFVASPDDYNVASNSIHADLNNPVMELALKNFVANYRQVKADIWAHNGPALLLRVLKKWCNTSDVASMNYVRCKGFHVLPRPTFNPVHFSNWDELFVQQQRSTIKETSTTGTPKWLTDQVIGVHTCNKMSNGGLLFKNSTQGYIRLARQHCPRIFSIAPETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GHE0</accession>
    <name>E9GHE0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_242777</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732544">
        <property type="protein sequence ID" value="EFX81177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81177">
        <property type="protein sequence ID" value="EFX81177"/>
        <property type="gene ID" value="DAPPUDRAFT_242777"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_242777"/>
    <dbReference type="HOGENOM" id="CLU_759230_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="365" mass="39015" checksum="42F5DFC5FAEB89BD" modified="2011-04-05" version="1">MDIITECGSVTFEAATEEIRKIKDGLDSPAGSLTSLDDGNLGENTSFAASTPLSNFSPVNKVHSGNRPFPSKPSVAKKHGVHPSPSPRSLNRSRSSNIGGSKMPRTSSDVLSCIVSMSPLSEVAGGSSQVADGKNKTNSLSVRDAMWKLKPTDARLKRPSSYPTRPVVAGIRKTGSSRSVEARSQSTLNLNVASSSKEINHIITPAVASTSKAKHDTETLVVAMVDGASMSTRHAEASTADISADKYVLRQEMLKQTLATNALLKDLIPPKRLITKVPQTYLEQFTTTVENTLSLPLTQIDDVTVLNIALLDMQLSVSLSTVQIDKLRLLTTENIIAKSLLANFCVTESAIRCSGRGVVKIFGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9GHP4</accession>
    <name>E9GHP4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_318039</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="GL732545">
        <property type="protein sequence ID" value="EFX80873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80873"/>
    <dbReference type="EnsemblMetazoa" id="EFX80873">
        <property type="protein sequence ID" value="EFX80873"/>
        <property type="gene ID" value="DAPPUDRAFT_318039"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_318039"/>
    <dbReference type="eggNOG" id="KOG2287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036849_3_0_1"/>
    <dbReference type="InParanoid" id="E9GHP4"/>
    <dbReference type="OMA" id="PIDINAQ"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="PhylomeDB" id="E9GHP4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX80873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="347" mass="39269" checksum="69FA2D0FE0671E62" modified="2011-04-05" version="1">MARNIVANSASEGRELSGYTGYTVQRLGLKPLPVPPLEPNNKESVVNDVLSFHYPIDINAQQQFKCPYWTDQSLNASGSIDTTLLIVVISAAGHSAKRNLIRTTWAGPSLLNVDWIQLIFLVGSTPNEDKILKDRLEKENAQHQDLIQVNVVDSYANLTLKSIALLHWAHGHCPGAKFVLKCDDDTYLNFNVLVNLLGKEQFQQSDRLYGLGIVQDRPQRDPNNKYYISRTVWPWNMYPAFLSGGGYLMGRDTIQPLLSATQTTPFFPLEDVFLTGICARKARITSVSSRRIYERFIPKKLDACFVRATAMWQTQSKIQFLQSHNIVSLIYQRRLPCRTACKYLGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GI94</accession>
    <name>E9GI94_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_243221</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732546">
        <property type="protein sequence ID" value="EFX80811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80811">
        <property type="protein sequence ID" value="EFX80811"/>
        <property type="gene ID" value="DAPPUDRAFT_243221"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_243221"/>
    <dbReference type="HOGENOM" id="CLU_671330_0_0_1"/>
    <dbReference type="InParanoid" id="E9GI94"/>
    <dbReference type="OrthoDB" id="739783at33208"/>
    <dbReference type="PhylomeDB" id="E9GI94"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX80811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="464" mass="52297" checksum="AE37FD4B66B12C91" modified="2011-04-05" version="1">MRPCNTDTNSKYTRISYEVFKPIPSTVNLKKERPVCISFTLDEGHGDHYVKLACGGVEVGPIPQQRHLQKESCYTEVPEYCTKAPGYYTTTYAALSYYTESPQYCSSPSYTTKGSITTPMLRSTAQLQIMERKGERNQSSGHLRHGNSSCSAMAQYYTITYVTPRLCTKAPECYTEGTNFYTTKALEYYTTTYHVNYGGVLLLGVVSLMAGSTTGVPMSSGYGDYQTSTSAAPAYYTEALKCYSIKAPVYYSTAHVALSYYAECPKYFFPSYTTEGSSTTSRLPSTTSPRHRSTKTVDYYTEAIIGYYTEYLTCHTTEAPKYCTTTYVAPAYTTKAAEYYTTKAAEYYTTKGAEYYTTKAAEYYTTKAAEYYTTKAAEYYTTKAAEYYTTKAAEYYTTKGAEYYTTKAAEYYTTKAAEYYTTKAAEYYTTKAAANSYYTTKANEYYTTSYASTTYYIEAPKFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIV5</accession>
    <name>E9GIV5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reelin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_303992</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80588">
        <property type="protein sequence ID" value="EFX80588"/>
        <property type="gene ID" value="DAPPUDRAFT_303992"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303992"/>
    <dbReference type="eggNOG" id="KOG4293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091827_0_1_1"/>
    <dbReference type="InParanoid" id="E9GIV5"/>
    <dbReference type="OMA" id="NSAWGHA"/>
    <dbReference type="OrthoDB" id="1223313at2759"/>
    <dbReference type="PhylomeDB" id="E9GIV5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reelin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="179" mass="18580" checksum="140FE1872E4530DA" modified="2011-04-05" version="1">MLDCQKIFKRICLTTLVLYLLTPNGNKIAVHGSSSGSPVQACADMVPAHHVDAQTSASPFVTKPSVTSAGNDSTITLTLASASPGIAFKGFLIMGFNNANHTEGPIGSFSSISNGQIIDCPGGSPKNAATHSNSDNKTSVTVDWTAPAQFVGTVLFKTTYAENGGIFWVATKSAPVTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJ39</accession>
    <name>E9GJ39_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_318532</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="465"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX80379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="572" mass="65356" checksum="67D80D6220CE0FA9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJR3</accession>
    <name>E9GJR3_DAPPU</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732548">
        <property type="protein sequence ID" value="EFX80155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX80155"/>
        <property type="gene ID" value="DAPPUDRAFT_318817"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1788788_0_0_1"/>
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    <dbReference type="PhylomeDB" id="E9GJR3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX80155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="145" mass="16910" checksum="BAF3EE686EF4B93F" modified="2011-04-05" version="1">MVRNYIRKIDSVEYPPGHIVFTDLQENLLVKYLNRSSDTKHGLTTRDTRKWAHDYARKLQLKCPENFSTNLTAEGKDWLAGFLNKVTLTEGQNFDLPKFSCLTDGENELLLCWKSFNLSQKLRQGFQLDNQVAKEKRQSSLKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
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    <name>E9GN33_DAPPU</name>
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            <fullName evidence="4">Thiopurine S-methyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.</text>
            <dbReference type="EC" id="2.1.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78965"/>
    <dbReference type="EnsemblMetazoa" id="EFX78965">
        <property type="protein sequence ID" value="EFX78965"/>
        <property type="gene ID" value="DAPPUDRAFT_225254"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_225254"/>
    <dbReference type="eggNOG" id="ENOG502QSF5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085515_2_0_1"/>
    <dbReference type="InParanoid" id="E9GN33"/>
    <dbReference type="OMA" id="LWCGDFF"/>
    <dbReference type="OrthoDB" id="1590477at2759"/>
    <dbReference type="PhylomeDB" id="E9GN33"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008119">
        <property type="term" value="F:thiopurine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025835">
        <property type="entry name" value="Thiopurine_S-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023956">
        <property type="entry name" value="Thiopurine_S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX78965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="229" mass="26524" checksum="6978A5BE3E2FE35E" modified="2011-04-05" version="1">MEERVKYWSKRWQAEDAPWHKTEVNEFLKNHFDQVCKIKEGKLRIFVPLCGKTQDLRWLYDLGHEVVGVDGVKKRKEFFKEQGLAYTEGNEGGLPYYVSDDGRLKIYYCDLFALNPEICGKFDGIWDRGSLDALLAEDRDKYAKLLKSVINENFGYLIHTIQYEQSQYPGPPLSVPVEEMKRLCGDISEVETLLNVSTKDDPTSLIPIKFPGNIDQCYENIFLLKPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPY9</accession>
    <name>E9GPY9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_320480</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX78472">
        <property type="protein sequence ID" value="EFX78472"/>
        <property type="gene ID" value="DAPPUDRAFT_320480"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_320480"/>
    <dbReference type="eggNOG" id="KOG0615">
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Pkinase"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX78472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="149" mass="16929" checksum="B518E167AFED3290" modified="2011-04-05" version="1">MTLRFIGEGRVGQRNVIARIPLHLVNAVDVWSPGVIFFYMLSGYHPFSDALSTSENSIAIFYWKKNWDSISAEGFALVQKILKVAPLQRATIEDILEDPWMQDTTVVNKMKLIVFADSNAIDNQPYSLHINENESVEESVPKRQRLSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQ20</accession>
    <name>E9GQ20_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_53261</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat EBI family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX78483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78483"/>
    <dbReference type="EnsemblMetazoa" id="EFX78483">
        <property type="protein sequence ID" value="EFX78483"/>
        <property type="gene ID" value="DAPPUDRAFT_53261"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG0273">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="E9GQ20"/>
    <dbReference type="OrthoDB" id="1463197at2759"/>
    <dbReference type="PhylomeDB" id="E9GQ20"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016575">
        <property type="term" value="P:histone deacetylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
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        </location>
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        <location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="209" mass="23015" checksum="6CA17FC6AAA63ECD" modified="2011-04-05" version="1" fragment="single">QKGFQHSAYTFGIESHISQSNINGALVPTAALLSIIQKGFHFTEAEISVGDDGSEQPMESLSLIDAVMPDVASRQQQMQNNQKPQVVKTEPPNSNVDEPMHSYRKIETGVEIPASKSIVLRGHESEIFICAWNPTTDLLASGSGDSTARIWNMNDNSSSPTQLVLRHCIQKGGTEVPSNKDVNYLLEINCCSFCRNFVYCYLYVSNEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732559">
        <property type="protein sequence ID" value="EFX78031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78031">
        <property type="protein sequence ID" value="EFX78031"/>
        <property type="gene ID" value="DAPPUDRAFT_105619"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_105619"/>
    <dbReference type="HOGENOM" id="CLU_1027658_0_0_1"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="PhylomeDB" id="E9GR98"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX78031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="271" mass="29882" checksum="3137D19D76B47E71" modified="2011-04-05" version="1">MKAPIDFALKDCRFGKIENLKQLEQIAKHCNNLEQLGNFLGIVGDVCHLRCQNNVLFSRNSQQKSLRFTGKVIANIPRTTPDGSAEATVGGMDVLHALGFSEKDLLSSTFDLVMADKSTPLLVVGEKEVTANYEGISAKITITFSPDITGLLLSWYDCVSLGILHEDYPRPWRKQKTGTKINSVTSAARGEEPFVYTGFVPLNPSPDDIQRIGDDIANVFTAVFDQTGELNCMEGPDMIIELTDDAVPFYVNGSRPLPFADRPLVKQLLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9GRB7</accession>
    <name>E9GRB7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_305274</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Hatcher P."/>
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                <person name="Thomas W.K."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="182" mass="20473" checksum="ECA67BBDA3A2C39E" modified="2011-04-05" version="1">MDCIADNLHSEESQGHSASKEYQLIFVSRRSAVCEQRLKDKGVYGTLTSIDELPVDFFPLDSDVISMELDNVFKDLYVDNEISSLHQIAHGLTSLQSLYGIFPNVVGTRTFQPWVLHSVAKLKLFQLSSLDNAIVAFGGVKVSAFARDSGEIFLDSFDDSVIMINPDIPDERELREWLKDNQ</sequence>
</entry>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
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                <person name="Yamagata H."/>
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                <person name="Robertson H.M."/>
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                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Basu M.K."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="EFX75628"/>
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        <location>
            <begin position="1"/>
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            <end position="437"/>
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            <begin position="166"/>
            <end position="196"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX75628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="437" mass="49755" checksum="2C70774811765A71" modified="2011-04-05" version="1">MSLTFDYRPLPWLLLLLLVSEGTSDYRDGFEYPFITTRHPTPVRSYSMAPGWRQFYPENYDFSDYSRHITRTDPASRNSAAEQIPSGPYFAQELKRYYHKPAEEPHKVYQTSWNMIDSEGNEYSTVYNRPAMTGYRPSSSASSSSGILLPTDQYPFVLDAWQQQQQQHHVEQQPIKERPTRKPISKKPVRKKNKGVRPIHPGMFAVPVALTVAVTIDRLLASYKEDTTSQWLKLKTQFLSSPGYQQLVTKIPDKKHQYDIDKVADGLAPQSIASAYPNGVMGTLSLMAGLVWYLVNKSATPVIKMRQNSRGYSDSYSNNEDEESSTQTAINQLADYWLGSLKQTDCQQRAVCELVSQSSWLSSATRWSQSAYRSPMVQKAIESFKEEEELGAQLDDDESKLALLVQAASHGEQGVDCAAFYPHCSLPFHEESRDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9GY84</accession>
    <name>E9GY84_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">DAPPUDRAFT_323218</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX75557.1"/>
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        <property type="gene ID" value="DAPPUDRAFT_323218"/>
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            <begin position="461"/>
            <end position="499"/>
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        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
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            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX75557.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="566" mass="62495" checksum="7B42F1785BD60D87" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYR1</accession>
    <name>E9GYR1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH:ubiquinone oxidoreductase NDUFV2/24 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_231246</name>
    </gene>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_231246"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_231246"/>
    <dbReference type="eggNOG" id="KOG3196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_1_0_1"/>
    <dbReference type="InParanoid" id="E9GYR1"/>
    <dbReference type="OMA" id="VGKFHVQ"/>
    <dbReference type="OrthoDB" id="1396088at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005747">
        <property type="term" value="C:mitochondrial respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX75440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="243" mass="26726" checksum="DCCB51A16D9C8CD3" modified="2011-04-05" version="1">MISSTANKIGRALSSQVRSFTVSSASLSDSLFVHRDTPKNNPDVPFAFTKENVERANAIINIYPDGHKRAAVIPLLDLAQRQAGGWLPISAMHAVADMLSMPKMRVYEVATFYTMFNRNPIGKHFVQVCTTTPCWLNGSEKIMNCLKKKLNLNNGETTPNGEFSLLEVECLGACVNAPMMQINDNFFEDLTEKDTEEIIDDLKAGREPKAGPRNGRFAAEPRDGLTSLTEPPPGPGFKIQPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9H042</accession>
    <name>E9H042_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_108410</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732582">
        <property type="protein sequence ID" value="EFX74563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732582">
        <property type="protein sequence ID" value="EFX74591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74563">
        <property type="protein sequence ID" value="EFX74563"/>
        <property type="gene ID" value="DAPPUDRAFT_307232"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74591">
        <property type="protein sequence ID" value="EFX74591"/>
        <property type="gene ID" value="DAPPUDRAFT_251776"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_251776"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307232"/>
    <dbReference type="HOGENOM" id="CLU_1512149_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX74563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="178" mass="20346" checksum="BC0691305268E7E5" modified="2011-04-05" version="1">MVKRFKLTMSSLLSVGTLGRSLVYGCLLGMADTKASRRRHTTRPQHSQEPVEAHNYYTTKAPEYYTEADAAPSYNIKRTTPKLPSTKTTKSPEYYTYPPTYYTTKAAEYYTEPPKYYTNKAPEYYTTTCASLSLYTEAPKYYSALSYTTTTEAAKYYAAPTYYTAAAPSYYVESEYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9H167</accession>
    <name>E9H167_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_231296</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732583">
        <property type="protein sequence ID" value="EFX74387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74387">
        <property type="protein sequence ID" value="EFX74387"/>
        <property type="gene ID" value="DAPPUDRAFT_231296"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_231296"/>
    <dbReference type="HOGENOM" id="CLU_053928_1_0_1"/>
    <dbReference type="InParanoid" id="E9H167"/>
    <dbReference type="OMA" id="EATWIPI"/>
    <dbReference type="OrthoDB" id="1329223at2759"/>
    <dbReference type="PhylomeDB" id="E9H167"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237643" evidence="4">
        <location>
            <begin position="23"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX74387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="407" mass="43435" checksum="D06839322F60A128" modified="2011-04-05" version="1">MFAMKLLLLNILTATLVGLASSQSLVLVGGGLTDGNAEIWNKVVTLAGGKGVAKIGIFTTASSDPVGAAEYYVDMFVNVYGAASATYIPVTETSNNADDPAVAELARQQTGFFFGGGDQLRILTALRPNGRDTLVLTAVKDMLKAGAVVGGTSAGTACQSSAVMITSGASWDALTYGSFSGGPKPLRSNDLTYDEKGGLGLLDAGWVTDTHFSERGREGRLIRLLQDTRDRDIGTPRGFGVDEDMGLVVTDLYTKPVGTVIGTSGGVFFADVTNTVVVPSQNTFYAGVSAHYLTQDDSIDLTTGKITFASWKSPLRGNEYYTNADVSTDILSANLNRRWATFADQFFDNRRDDSIAHLSFERDPRFEVTFDRLNGAGYGGYFPSDPSTFIVSYENLQVAIHESTTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9H1D7</accession>
    <name>E9H1D7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_251980</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus</location>
            <location evidence="1 11">Golgi stack membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="GL732583">
        <property type="protein sequence ID" value="EFX74434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74434"/>
    <dbReference type="EnsemblMetazoa" id="EFX74434">
        <property type="protein sequence ID" value="EFX74434"/>
        <property type="gene ID" value="DAPPUDRAFT_251980"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_251980"/>
    <dbReference type="eggNOG" id="KOG2619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032075_3_0_1"/>
    <dbReference type="InParanoid" id="E9H1D7"/>
    <dbReference type="OMA" id="ADTRESH"/>
    <dbReference type="OrthoDB" id="551308at2759"/>
    <dbReference type="PhylomeDB" id="E9H1D7"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036065">
        <property type="term" value="P:fucosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="PTHR11929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glyco_tran_10_N" evidence="12">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX74434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="335" mass="39033" checksum="6D56D9874CDEC249" modified="2011-04-05" version="1">MKVFLRSLPNNNSCPFRNCRVTTDRRSNLLGKFDAIIFNMAVLHQLATDKLPPADTRESHQYYIFFSQESPFYHKENVQIKDYIGYFNWTMSYLPESNIPYPYGRIERAAAVDLKSKSYPRKKTKLVAWFVSHCNTTQSRRENYVRELQKHIPIDIFGLCGPLKCNWNSDTGISHPECYDMLEKEYKFYLSFENSLCSHYVTEKFYSILKLDVVPVVMGRANYSGIAPPYSFIDALRYSPKQLADYLLLLDGNQTLYERYLKWKTSYIIRSGYEEMGGQALCSLCAQLNLSDDRKEIMPAADVLSTWNPTTRCLNPRYVKAFHSIDRNNNRSTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9H281</accession>
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        </submittedName>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX74121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74121">
        <property type="protein sequence ID" value="EFX74121"/>
        <property type="gene ID" value="DAPPUDRAFT_324609"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_666089_0_0_1"/>
    <dbReference type="OrthoDB" id="1707680at2759"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="413" mass="47000" checksum="A1E0991822F7B471" modified="2011-04-05" version="1">MRFIIVDNRKFLPRDCRLTTVLGILKETAVLGRKTSWTHFGMAIVGENMFTNVLSLQDMKHLSLPGFNKAFEDAVKIINNNNAGFGSNFIEKKQKLLSNICPALQNTIKQFKELKEKKEKELLITIIAVHWERKVEQEIDEFFHSSRDASNVQIQVLEIGNTNFLKDSVVSEKVRVHSLPIKGLDISMEAICKSWAKRRPCDLKFNFPNNGPVVVAKVEDLFVDLRPSQSDLPQSLTITSVTYPIDLCRSYTYGRCVLLSSDTNTSANSYRWEALCKLAKNKETLLIAKEMNTFATYALIPCDDLRMLMQPIACVELLLPKPKPYATELISEDFEQITKKIRFTDEYGFGPKANIITLLKEEWMKNFTSYQHEPNSKIKGNQPTKKPKNNSAQMTNTKTCSLAHPALGMYSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9H356</accession>
    <name>E9H356_DAPPU</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_252633"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S2H8">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Transposase_37"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="510" mass="57393" checksum="83C9A8D55FD72B8B" modified="2011-04-05" version="1">METGEHLNLPIDIVTTLEEEDSVSSDTTTTSPPHQYRDSQLNGDNDHTETVESFELFNDRETTVEEDTASCETTTAFQSVASPTLQHPETDIIGGIDLMETGEPFKFVIETETTRDTASYNRPTTTSFQLVASPPQQDPETEIITYKTTNLQAVQELFVSLPVPHSNELLSLPPEATETTHSSDVTTANETTDAEIVGAPTVRGKKPKRVYRIKAPTYCECHKEIKGKCAPCQIRELKMLVQEKDKQLKIVRSYQVKATVDVAKLKRKLKETDKKLNTSSKQLARMRQYAVDCVETISKLKDDVATLTKNQLDEKTKHLTHGERVIINTFIMKGKAELKADTGRAYGMKYDAGFLMQCLLLKLKSSSTYNHLRKNNILPLPSPSTIRRRLSSSECKFGFNELALENIKKALANLPESERWGSIMWDEVSLKKDLTWHSSRLEWHGIVDFGEDIKGAVKSGIATHALVLMFRPYRGNWVQPFACFASKNAATFTILHEVKEKETANKTDKT</sequence>
</entry>
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    <accession>E9H521</accession>
    <name>E9H521_DAPPU</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732592">
        <property type="protein sequence ID" value="EFX73257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73257">
        <property type="protein sequence ID" value="EFX73257"/>
        <property type="gene ID" value="DAPPUDRAFT_325538"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_325538"/>
    <dbReference type="HOGENOM" id="CLU_3126491_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX73257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="50" mass="5841" checksum="46A9A558D0D89F68" modified="2011-04-05" version="1">MATSIFVVPMQLNKSYQQPNSDKDFKTPYLKEVWRYFCGFFNMDVVGVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5S1</accession>
    <name>E9H5S1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_308012</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus</location>
            <location evidence="1 11">Golgi stack membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="GL732594">
        <property type="protein sequence ID" value="EFX73035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX73035"/>
    <dbReference type="EnsemblMetazoa" id="EFX73035">
        <property type="protein sequence ID" value="EFX73035"/>
        <property type="gene ID" value="DAPPUDRAFT_308012"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_308012"/>
    <dbReference type="eggNOG" id="KOG2619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032075_3_0_1"/>
    <dbReference type="InParanoid" id="E9H5S1"/>
    <dbReference type="OrthoDB" id="551308at2759"/>
    <dbReference type="PhylomeDB" id="E9H5S1"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036065">
        <property type="term" value="P:fucosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="PTHR11929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glyco_tran_10_N" evidence="12">
        <location>
            <begin position="65"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX73035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="437" mass="50505" checksum="C33D6FD4D70D7C62" modified="2011-04-05" version="1">MAANIKKCCKLTAAAFIVSTFFLLCADRLARPDSNPHRPVELFQQPNHQCIDLVENNSTTVQGRIKTILLWNAPQRPEVVIFGTGHDAFVQRGCPVSDCELVNSPYQYPGRSVESYDAIVFNINDQFGVGSRRPYADGNQRPATQRYVFLTQEPPPALVDQNLAQYRNYFNWTMTYRMDSDVRLLYGRIRPKPSAPKTMGETEVRMKESTRQLMLNKRKITRRKKKEKKLVAAMISHCTTDGQREQYVKQLKKHVKVDVFGWCDDDGLGSGLRCDTHELLTSTPECYNMLDSNYKFYLSFENAICQDYVTEKFFHIMSLRDIVPVVYGGADYAQLAPGHSYIDALQFEPKQLAAYLEMLAANETLYNEYLWWKDDYTVEAGLEQMVRHGFCDLCRKLHVDNERIKSHPSLFPKWHPGRCSRPTYKLKKSPKKFPFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9H760</accession>
    <name>E9H760_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_254478</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732600">
        <property type="protein sequence ID" value="EFX72320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72320">
        <property type="protein sequence ID" value="EFX72320"/>
        <property type="gene ID" value="DAPPUDRAFT_254478"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_254478"/>
    <dbReference type="HOGENOM" id="CLU_1541698_0_0_1"/>
    <dbReference type="OrthoDB" id="1258047at2759"/>
    <dbReference type="PhylomeDB" id="E9H760"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="SSF49842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX72320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="174" mass="19408" checksum="B3898EF91538898F" modified="2011-04-05" version="1">MLGTTDDDDIRSPWFPLLKRRPPVDLRQCMCFGGGWARAITEPAPLIYTTGWPQQHEARIDPPVTFESAPSSIGRIPKSFEDLGKIGQRKSGLFKVIGKQSTTSSAYWNPNTVIPFKFMRLNVGNAMRLSGIFVAPKSGKYFFSFLGISEGHKESRVELQVKTEIADWSKVGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9H769</accession>
    <name>E9H769_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_201098</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="EMBL" id="GL732600">
        <property type="protein sequence ID" value="EFX72418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72418">
        <property type="protein sequence ID" value="EFX72418"/>
        <property type="gene ID" value="DAPPUDRAFT_201098"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_201098"/>
    <dbReference type="eggNOG" id="KOG1221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024661_0_2_1"/>
    <dbReference type="InParanoid" id="E9H769"/>
    <dbReference type="OMA" id="QELIYHI"/>
    <dbReference type="OrthoDB" id="815047at2759"/>
    <dbReference type="PhylomeDB" id="E9H769"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX72024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="61" mass="6494" checksum="110BC0107249ADAD" modified="2011-04-05" version="1">MTNNNAKQRCNELDKSTTANKGTLENSSVLVGCSSLEAAIDELGLLGPVPQSTSYGFMSHY</sequence>
</entry>
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                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732603">
        <property type="protein sequence ID" value="EFX72035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX72035">
        <property type="protein sequence ID" value="EFX72035"/>
        <property type="gene ID" value="DAPPUDRAFT_326618"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326618"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="E9H8A3"/>
    <dbReference type="OMA" id="DCAVENT"/>
    <dbReference type="OrthoDB" id="1343623at2759"/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Tsuchiya D."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="entry name" value="Peptidase_S1A"/>
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        <property type="entry name" value="Trypsin_dom"/>
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        <source>
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        </source>
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    </evidence>
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    </evidence>
    <sequence length="243" mass="25745" checksum="187B3865AC82540F" modified="2011-04-05" version="1" fragment="single">TATAKIVGGVPADWGQLPFVVALESPRGQQLCGAAILNERWLATAAHSHQIVAIAGSLDPSSSASSSNASNRQVSEGAEVRLAPGYAQGTQLDLALIRLKRPFKWRNGIVEPVCLPKDRAAMDQLGTVAGWGWNDEEGVNMSNKLHRVQVPLMSRAECEKRFLAAGYAIPIDKTKICAGWPQGGQDACQGDSGGPLVVSQDGVFVLTGVVSGGIGCARPGLPGLYTNVAHFLPWILDIIKKRK</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Pritham E.J."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX70855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PhylomeDB" id="E9HBK1"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="93" mass="10396" checksum="E39EA2F195AD3C2C" modified="2011-04-05" version="1">MAPAAKAFKPYGSPPRFDLDEFKDSFELWHAQWKIFLALSTIDTVLEEDERPEYKTNVLLSCLSKETLQAVLSMGLDGVTRGVIATYGVNSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9HBK2</accession>
    <name>E9HBK2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_327730</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732616">
        <property type="protein sequence ID" value="EFX70856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70856">
        <property type="protein sequence ID" value="EFX70856"/>
        <property type="gene ID" value="DAPPUDRAFT_327730"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_327730"/>
    <dbReference type="HOGENOM" id="CLU_1612493_0_0_1"/>
    <dbReference type="InParanoid" id="E9HBK2"/>
    <dbReference type="OrthoDB" id="49443at2759"/>
    <dbReference type="PhylomeDB" id="E9HBK2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="SSF47762"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX70856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="165" mass="19133" checksum="6F287E8EE83CDCAD" modified="2011-04-05" version="1">MTDDDPVQPRRDAYARIYFMEVRSRLEQSNPMAFKEFVTVLAQLQSTPDSFLEFYRKIESILKDNMDLLEEFVLFLSPEAAAQCGVQFQHFLYVRMREFFSKLKIHFKDSPSQLERTLKTLQQVESSASPNINDIKNTILPLLKGNAHLTQGFLQLFPDDVPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCZ6</accession>
    <name>E9HCZ6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_112758</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732622">
        <property type="protein sequence ID" value="EFX70386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70386">
        <property type="protein sequence ID" value="EFX70386"/>
        <property type="gene ID" value="DAPPUDRAFT_112758"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_112758"/>
    <dbReference type="HOGENOM" id="CLU_1278764_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="216" mass="24616" checksum="50C2603B11DFD00A" modified="2011-04-05" version="1">MMNFVLHFQQPRIQIFYLQSMDLDTSSTDFLQETSVFQSFHASRKSANNNISHFQNVIRPPDVHQLLNSPKINAILCILHSVTPKYYPRSENTPFSPICCKQRTVARRVKGWKRRRGTEIQLERFNDKSVDSLKQDSGAVLLVSGHVGSRANGLMKAEAKKGSRPTEYLVRYDSTLEILNMELKLDHNVGLCIPPHAGGSSPHFLFDTFCRVMQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGP7</accession>
    <name>E9HGP7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="1">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_203047</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732643">
        <property type="protein sequence ID" value="EFX69085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69085"/>
    <dbReference type="EnsemblMetazoa" id="EFX69085">
        <property type="protein sequence ID" value="EFX69085"/>
        <property type="gene ID" value="DAPPUDRAFT_203047"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_203047"/>
    <dbReference type="eggNOG" id="KOG1076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004304_0_0_1"/>
    <dbReference type="InParanoid" id="E9HGP7"/>
    <dbReference type="OMA" id="VVMHRSE"/>
    <dbReference type="OrthoDB" id="273138at2759"/>
    <dbReference type="PhylomeDB" id="E9HGP7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="PTHR13937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50250">
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
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            <end position="823"/>
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            <begin position="251"/>
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        </location>
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        <location>
            <begin position="858"/>
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            <begin position="163"/>
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            <begin position="858"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    <sequence length="916" mass="106321" checksum="2F88DA2D6A368466" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9HIJ5</accession>
    <name>E9HIJ5_DAPPU</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">DAPPUDRAFT_330101</name>
    </gene>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="QNSHYFR"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX68449.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="464" mass="56974" checksum="DE0F855B7DFA725F" modified="2011-04-05" version="1">MRLENEIIRKREAETRRSETARSNDRYFQNCNLQNEKFGDWTSPRSAQLSHRQSKIRETEIDVETRRKKLKKLYQEDRLNEEQALKKIKQEEENQKWENMKDKVQHFRHSKSVKLNEFVENREHEQWKSTSASFRAFESELKKQQQQEMWTIQLQQREEEKLRLLEEKKREAVQMERLVQEERKREEIEQKMELQKKQQWRKDLDEQVELLGSKDFEANEKRREHDKLMAEAAALEAIKEEMQKKEEERAKRQQNGEFLTKQHLAKLRQRSKEVAADLEREMSFAEKLFPNESDSALEKEKTRQDIQRFLQLVENHRRIEKERLQQSEFLFQEEAKRMWEKRELEWEAERLARKKLIEEVIAIQEKQIDQKIIAARQERQQLLRDREELVHSLESYHNQAKKKEMENKAKQFQTKVDLQAQIDHKQQREEEFNNLERQKRKHQELMEAAHNEKHWNIAMDKLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJR7</accession>
    <name>E9HJR7_DAPPU</name>
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        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_301715</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="GO_Central"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sugar/inositol_transpt"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="198"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="348"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX68023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="507" mass="55816" checksum="44B1FE87BF23D996" modified="2011-04-05" version="1">MKTRKTVPPFKNWQKVAPQIVCATSASWAMLCTGLVRGWSSSAIPQLTAEKNDTLHLEQEEAAWITSLPPLCGIFGSLMIAFPMELFGRRMTLATISVPYVLGFYLMGLSYYVNWTPLLFIGRVITGLLTGASAPTSQIYVSECASPRIRGALGSFTATFLSLGILIAYIIGAVVEWQILCFIIGSMPIVLGLAMMFMPETPSWLVAHNQETRAKVALQQLRGKYTDIEPEFERIKFNDNSHGSNNIRYIKILTSCHLMKPLLISMALMFFQQFSGINAIVFYSASIFQEAGSTIDRFVSSIMIGVVQLIFTVISALLVDRFGRRVLLMTSGTLMAVSLSGLGAFVYVKKAWEELSVVDESTVEEQNLLAELGWLPLLCLMSFIISYSFGFGAVPQLVMGELFPSEYRHRMGTISVSFSVLCTFVVVRTFPLMATTMGLASVYGLYATCCLTAVVFVGLFLPETKGKTLEEISSFFGQSQPNDVAAEDPCIPLEHKTELQDSSLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HL00</accession>
    <name>E9HL00_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_330915</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732674">
        <property type="protein sequence ID" value="EFX67584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67584">
        <property type="protein sequence ID" value="EFX67584"/>
        <property type="gene ID" value="DAPPUDRAFT_330915"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330915"/>
    <dbReference type="HOGENOM" id="CLU_1817708_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="142" mass="15941" checksum="9B3370AF89D08A8C" modified="2011-04-05" version="1">MYFKASTSELSFTSDDWTEKTILDHDTHKSIADLPVLKTSLQDVMDPTPMDTNNNEAEEILPQETIHHHSETTLPNLADPPNEAAEITTNDDPSQIKPQSSTCQPKFEQTTLNLLNHRATQKQSPALMQNTGFQPYSMNMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9HL25</accession>
    <name>E9HL25_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_Tnp_Tc3_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_63850</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732675">
        <property type="protein sequence ID" value="EFX67530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67530">
        <property type="protein sequence ID" value="EFX67530"/>
        <property type="gene ID" value="DAPPUDRAFT_63850"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_63850"/>
    <dbReference type="HOGENOM" id="CLU_1998190_0_0_1"/>
    <dbReference type="InParanoid" id="E9HL25"/>
    <dbReference type="OMA" id="FGSHENG"/>
    <dbReference type="OrthoDB" id="1553369at2759"/>
    <dbReference type="PhylomeDB" id="E9HL25"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Tnp_Tc3_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="125" mass="14449" checksum="FE862B0BF344B96F" modified="2011-04-05" version="1" fragment="single">TIFRRLQKEGLHCRIAAKKEFLTNAQKEQRMAFATAYADKDEQGWRSVIFSDEKTFGSHENGRPFVIRTNGTRFVPGHTFSIKRSGRKSIPVWGWFSFDEAGAIHHINGRLTAEKYIRVLEDHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLU3</accession>
    <name>E9HLU3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G_PROTEIN_RECEP_F2_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_64004</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732681">
        <property type="protein sequence ID" value="EFX67288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67288"/>
    <dbReference type="EnsemblMetazoa" id="EFX67288">
        <property type="protein sequence ID" value="EFX67288"/>
        <property type="gene ID" value="DAPPUDRAFT_64004"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_64004"/>
    <dbReference type="eggNOG" id="KOG4193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1253355_0_0_1"/>
    <dbReference type="InParanoid" id="E9HLU3"/>
    <dbReference type="OMA" id="AFICKAR"/>
    <dbReference type="OrthoDB" id="1153592at2759"/>
    <dbReference type="PhylomeDB" id="E9HLU3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F2_4" evidence="7">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX67288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="221" mass="24304" checksum="C598D5CB805E44FE" modified="2011-04-05" version="1" fragment="single">FILYSMYAWLVPGLIVAAAVAVEYVDTDLFSWMPAEYRPFFGRNVCWFGQRKAILIYFAAPLTIILSVNLLLFISSAHMIRSTTSKSPASSNQAGTRKQLGLYVRLALIMGLSWLAGLIAGAADFMPLWYVFVALCSLQGVFILLAYTCNPKVIRSIRNKICGCRKPKGRQSTYRAGPAGGLKSEDLRRQGKANVCDSQDSNTSHLSRTSLSTKTTSTTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNC2</accession>
    <name>E9HNC2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_116030</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732695">
        <property type="protein sequence ID" value="EFX66771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66771">
        <property type="protein sequence ID" value="EFX66771"/>
        <property type="gene ID" value="DAPPUDRAFT_116030"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_116030"/>
    <dbReference type="HOGENOM" id="CLU_754921_0_0_1"/>
    <dbReference type="OrthoDB" id="1794458at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX66771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="367" mass="41630" checksum="134B19D262B7FBCA" modified="2011-04-05" version="1">MAWKSNNDVFRRIGFWLVAVTVISSTSVCSASFNSTGVAVRSSDVKKSFPRSTTESQLVTGRPLDFLSPRDSSCPLTKNELRQMDELLSSFNDTVRSDRLRCDNLEDDREPLMVSLSSADRCSQLKESILSNVNDLKMVFQCLKVTGDKDDDVYKTLKTTYETKMRRLQQQADSAKKQFETKFNQEINRLKKHLQEIEKEMRVTLEQLGKELEETNTKLILLYLEQGKIPMACSTFKDKLNLQHSRTNINAIVKIAIGKELGTNISMENVVKFTQGLTDDAEAMAHGAIRLFQILEHKQALDVPTVHILHGAVGNIIGSCKSLEGTDFETLKLILDEDTVDRVIQVFNKLEFLIKNVQLQLQYLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNG7</accession>
    <name>E9HNG7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_331799</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732696">
        <property type="protein sequence ID" value="EFX66663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66663">
        <property type="protein sequence ID" value="EFX66663"/>
        <property type="gene ID" value="DAPPUDRAFT_331799"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_331799"/>
    <dbReference type="HOGENOM" id="CLU_121118_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HNG7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX66663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="192" mass="22028" checksum="4CD9FC524158E779" modified="2011-04-05" version="1">MSYSEKRKRTCEYEDEDIRHRRPQRIRLAKTSSELNVVGLRNVGEKIRLERSNKLPKMDEGVSPLLRGNGMEVDEDVEEIARNLPRDKSNNRQRRIATNPEPNQHLSVRNTNRFKTLTTGKIGKGHQTRQPDRGNRLKNLLVVNLSNRGRIVDLTGIGSKPNVTAGEGKDLRSLLDSKRKKKSREFRTLGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9HP61</accession>
    <name>E9HP61_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_302683</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732703">
        <property type="protein sequence ID" value="EFX66453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66453"/>
    <dbReference type="EnsemblMetazoa" id="EFX66453">
        <property type="protein sequence ID" value="EFX66453"/>
        <property type="gene ID" value="DAPPUDRAFT_302683"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302683"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1251778_0_0_1"/>
    <dbReference type="InParanoid" id="E9HP61"/>
    <dbReference type="OrthoDB" id="1527337at2759"/>
    <dbReference type="PhylomeDB" id="E9HP61"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOCS box" evidence="1">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX66453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="221" mass="25620" checksum="CDFCEA944112AF2E" modified="2011-04-05" version="1">MHRLKDDELAELLIRSGANLNSTDFYGHTPLWVATKGQRPLLVAKLLAAGSRVGSVDDYPWSQCPLYLATKYLGYRGRHQLAMFLMAAGADPTRMDSKGRSAIYWSLRNRDHDLFAFMIDSFNPRCWDSMLQKRVEELIEELPETHLKTLQNQLYNPPSLAKQCRLVIRLHLLQKFNYRSLFLLVPRLPLPVLIQRFLLLDQELPDEETTPCYMKDISIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HQL1</accession>
    <name>E9HQL1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_332668</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732722">
        <property type="protein sequence ID" value="EFX65969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65969">
        <property type="protein sequence ID" value="EFX65969"/>
        <property type="gene ID" value="DAPPUDRAFT_332668"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_332668"/>
    <dbReference type="HOGENOM" id="CLU_601665_0_0_1"/>
    <dbReference type="OrthoDB" id="1494583at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="455" mass="50236" checksum="D4AC89912E2510DF" modified="2011-04-05" version="1">MSVRRSPVRNEVQWRESTAAATPDPQPSSQQSSGRHFSTKICVTCNNDYTPTAYHQKYCSTCGRNPARRKSQALVDNTQNPPNADIHSDIDTQSDNQSDNVFGIYATGSTLSTPYQPSYFTIDPSANTKRGNVHFSPLDDAADDKRTRNDCHTEAELTKLPLQQLIGIILAQQSKMNKLIAKRNSSEDALYAEKMKTKDLEENFNKTSAELLQAKLCFAEDFLSTMKRPATYADAVKSKQPESPGPVTLIADLCNGELNVPELKAIEDLLGSRDGGPVAQSSFHRDGKLFITFGQQKEMDTAIHILNSAPNAKEVISATSLPKKLYLMIIRDVMTTNYSGPAEIIADLNCVDGNRCLKAHVTRANVIFTNKRSGKSLVKLLIDSRDARDEALSRGRIYSKSGASYATVAVNPEREIRRCYTAAATVILPQNEFWSSPPSDILNLKTTKISPNQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9HR62</accession>
    <name>E9HR62_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_65192</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL732731">
        <property type="protein sequence ID" value="EFX65775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX65775"/>
    <dbReference type="EnsemblMetazoa" id="EFX65775">
        <property type="protein sequence ID" value="EFX65775"/>
        <property type="gene ID" value="DAPPUDRAFT_65192"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_65192"/>
    <dbReference type="eggNOG" id="KOG1217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041204_0_0_1"/>
    <dbReference type="InParanoid" id="E9HR62"/>
    <dbReference type="OMA" id="IGNSECA"/>
    <dbReference type="OrthoDB" id="106876at2759"/>
    <dbReference type="PhylomeDB" id="E9HR62"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="SSF57184"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="186"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="285"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="344"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX65775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="391" mass="41262" checksum="2784E95F64AAEE01" modified="2011-04-05" version="1">MTGDPFVRCTEPVVVQPETVTTRPKDPCTPTPCGVGAECRSQGNSATCKCPINYVGDPYTGCRPECVQNSDCPRDKSCANNRCINPCPGVCGLNAECRVINHYPVCSCISGYTGDASSACLKKPPTPNPCVPSPCGANAVCRDQSGLAICQCLPEYFGDARQGCKPECVLNSDCASTQVCVNQKCRDPCPGLCGNNAECRVVNHFATCYCPQGYTGSPLESCRPECLLNSDCESTLACINQKCKDPCAGICGQGAECHVVSHNPICSCPRGKTGDPFIECRPTPVVKPCDPSPCGPNSICRPVGSEPVCSCQSGFDGVPPECRPECISSSECPPSKACVNMKCQDPCPGACGRDAQCRVVNHSPICICPSGWTGDPLTGCRIIPSKHDYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9HRK0</accession>
    <name>E9HRK0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_65368</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732737">
        <property type="protein sequence ID" value="EFX65629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65629">
        <property type="protein sequence ID" value="EFX65629"/>
        <property type="gene ID" value="DAPPUDRAFT_65368"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_65368"/>
    <dbReference type="HOGENOM" id="CLU_019033_0_0_1"/>
    <dbReference type="InParanoid" id="E9HRK0"/>
    <dbReference type="OrthoDB" id="32123at2759"/>
    <dbReference type="PhylomeDB" id="E9HRK0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035064">
        <property type="term" value="F:methylated histone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038028">
        <property type="entry name" value="BPTF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="7">Structural component of the gap junctions.</text>
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    </dbReference>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="1 2" key="1">
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kriventseva E.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="91" mass="10782" checksum="3D241785C2CF3753" modified="2011-04-05" version="1">MTKTLRHLEITLFDSFTSRLFDVQSELEFIRLLDSIDDEDLADPNFCFIVQYYAMTGPIKQFQLAKFEVDQRFGINQMPCHFRRSPRSTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9HW56</accession>
    <name>E9HW56_DAPPU</name>
    <protein>
        <submittedName>
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    <gene>
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    <organism evidence="3">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX64022.1"/>
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        <property type="protein sequence ID" value="EFX64022"/>
        <property type="gene ID" value="DAPPUDRAFT_5682"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG0575">
        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
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        <property type="term" value="C:spindle pole"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX64022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="171" mass="19915" checksum="87FE0EB8ECFDB84F" modified="2011-04-05" version="1" fragment="single">IPDILFDPDTKKGYVRGEFLGKGELAKCYELSDSATNQTFAGKIVSKQRLQKQHQKDKMAQDISIHHLLVHKNIVGFHSFFEDSNFVFIVLELCKRRNLMELHKRRKAITEPEARFFMHQLLLGVKHLHENKIIHRIDLKLDNLFLNEGMAPKIGDFGLATKLYFDGERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9HWH5</accession>
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        <recommendedName>
            <fullName evidence="1">Peptidase_M13 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">DAPPUDRAFT_267439</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX63907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NEPRILYSIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="92" mass="10396" checksum="C2816929202B9452" modified="2011-04-05" version="1">MFATAADLPTPGPLINQIQSLEVKRSEAQNIDFRIWCKVLNGDGYEKYTQEAHSPGKYRANGVLQNSPTFSQFFNCRLDSPMNPANKCQLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
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    <name>E9HYW8_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733235">
        <property type="protein sequence ID" value="EFX63063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX63063"/>
        <property type="gene ID" value="DAPPUDRAFT_269136"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_269136"/>
    <dbReference type="HOGENOM" id="CLU_1300812_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HYW8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="212" mass="24239" checksum="E31432A11007D588" modified="2011-04-05" version="1">MASIYNEEDEEGQEIIPDNSAYNQLWQRALDVEEVVQRILQEHALPINDDELEHAEEAQEEEEGEMNSSTSDGMGNNPASAWFHNSLQHLSHSWHRFNKFDISRDKKADRCSTWFVDQANNNNKPVKPLPFYSFARRTISEESIDFFDRFSKISERANTQRIPAGRRGQQPNANVVEEAFARADRINQLDRQRGVSSPQLSDGSDEAAESAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9I034</accession>
    <name>E9I034_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_67833</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733461">
        <property type="protein sequence ID" value="EFX62646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX62646"/>
    <dbReference type="EnsemblMetazoa" id="EFX62646">
        <property type="protein sequence ID" value="EFX62646"/>
        <property type="gene ID" value="DAPPUDRAFT_67833"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_67833"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_9_1"/>
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    <dbReference type="OrthoDB" id="921996at2759"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX62646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="115" mass="12961" checksum="B6A3697957F0D8C6" modified="2011-04-05" version="1" fragment="single">GLGLAVAEQLANRGAIIIFTARDLDKGLAIQESLRERTKNPKIFCEYLDLNNFVSIHQFVSRVNQKCSKVDLLINNAGVFFHPPKETVDKFDVTFQTNYLGHFLLTELLLPVLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9I0M1</accession>
    <name>E9I0M1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="2">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_93870</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="2"/>
    <dbReference type="EMBL" id="GL733577">
        <property type="protein sequence ID" value="EFX62457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX62457"/>
    <dbReference type="EnsemblMetazoa" id="EFX62457">
        <property type="protein sequence ID" value="EFX62457"/>
        <property type="gene ID" value="DAPPUDRAFT_93870"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_93870"/>
    <dbReference type="eggNOG" id="KOG0888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_1"/>
    <dbReference type="InParanoid" id="E9I0M1"/>
    <dbReference type="OMA" id="ALWFGEQ"/>
    <dbReference type="OrthoDB" id="1334716at2759"/>
    <dbReference type="PhylomeDB" id="E9I0M1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX62457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="144" mass="16148" checksum="CF7EF5FD97F99152" modified="2011-04-05" version="1">MIKPDGVQRGLVGEIIKRFEQKGFKSVALKFVQPTEEMLQKHYADLSGRPFFAGLVKYMASGPVVAMVWEGLNIVKTGRQMLGETNPADSKPGTIRGDFCIQVGRNIMHGSDSVESANKEIALWFKDEELVSWQPADKVWVYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2Y0</accession>
    <name>E9I2Y0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734282">
        <property type="protein sequence ID" value="EFX61650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61650">
        <property type="protein sequence ID" value="EFX61650"/>
        <property type="gene ID" value="DAPPUDRAFT_338577"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_338577"/>
    <dbReference type="HOGENOM" id="CLU_730089_0_0_1"/>
    <dbReference type="InParanoid" id="E9I2Y0"/>
    <dbReference type="OrthoDB" id="1114912at2759"/>
    <dbReference type="PhylomeDB" id="E9I2Y0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="147" mass="17552" checksum="4CB410CD1B4EC974" modified="2011-04-05" version="1">MRKLCDYIENTWIDSLLWPPKVWSVFMQEVRTTNDVEGWHTHLANHAGLRISSRGLNLYILLEVLNEEAVQVDLYTKMLEQGQSLRRQRKTYRELNEKLFKFWDDYNKQHLTSKELLEKCANIYTHFNAIKYAKTANDARVTEIETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2Y2</accession>
    <name>E9I2Y2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_272349</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
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                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="9"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX61645.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="63" mass="6701" checksum="1339FF718F8C0F1A" modified="2011-04-05" version="1">MTPGTKSGGGAEKDKHGAENDKTVPKTTKSKCRKKVPKQVATNNLGTIAKSGTKAYMEAFCWS</sequence>
</entry>
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    <reference evidence="1 2" key="1">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="196" mass="22630" checksum="5DE43C57C01ED54D" modified="2011-04-05" version="1">MFVFQTSLQAWRLSITGAINLIEEQFEAGIRVVLTGKFNHDPLEMLFGIIRSVDSHPTVTSFLQIIRYVSLQCRLSCLVKQVKGSNIDNKEPIEMLVTMSKCHQEHAKESDITVKEHKEAIKDKLLDELTIRYVDDLPKECTNDFNLNVMKLVCCDELDLPEDFTADQYTRMRNRGFLIFVTVPFFKTLLVVEQVI</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734998">
        <property type="protein sequence ID" value="EFX61142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1782071_0_0_1"/>
    <dbReference type="InParanoid" id="E9I4D8"/>
    <dbReference type="OrthoDB" id="266752at2759"/>
    <dbReference type="PhylomeDB" id="E9I4D8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="146" mass="16251" checksum="474F3C9AA113353F" modified="2011-04-05" version="1" fragment="single">KYYTDAPVHYTTAYAKPQPPSTTPKEPPITQQLNYGVVLLLGVVSLMAGSNAGVVMSSCYTEAPADNYTKTVEYYTDAAKYFSARSYSTRTKAANYYAVLTYNPEAALSYYVEQKYYTDAPVYYTTTYASPSYNTAAAKYYIPARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9I5H2</accession>
    <name>E9I5H2_DAPPU</name>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Choi J.H."/>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Wolf Y.I."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
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        </lineage>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX59973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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    <name>E9I827_DAPPU</name>
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    </protein>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the CFAP97 family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="153" mass="17887" checksum="D32337DB42DF7B84" modified="2011-04-05" version="1" fragment="single">MHANAWNLRSSKERLQIMERTEAQKKHLLNILAAKSHLDNRNPTNPKHSPSAPLALLQRKILQQDNRGMVSRIMRIAQDKPALSRTHTELTSLVRNLKAYSSLNRSMRLRAIEEENCRIFSRLVSTSPTIRREQWRKSNLQTSKYKENLHRGK</sequence>
</entry>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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            <taxon>Daphnia</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_300159"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300159"/>
    <dbReference type="eggNOG" id="KOG3018">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="PhylomeDB" id="E9FRB3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:malonyl-CoA decarboxylase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001294">
        <property type="term" value="P:malonyl-CoA catabolic process"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0046321">
        <property type="term" value="P:positive regulation of fatty acid oxidation"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038917">
        <property type="entry name" value="Malonyl_CoA_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007956">
        <property type="entry name" value="Malonyl_CoA_deC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042303">
        <property type="entry name" value="Malonyl_CoA_deC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035372">
        <property type="entry name" value="MCD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038351">
        <property type="entry name" value="MCD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641">
        <property type="entry name" value="PTHR28641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05292">
        <property type="entry name" value="MCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17408">
        <property type="entry name" value="MCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCD_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="MCD" evidence="1">
        <location>
            <begin position="70"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX90135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="389" mass="43992" checksum="F94305FE65E0887A" modified="2011-04-05" version="1">MIKAEDNLRNTLAVEQNWMLSILARQEGGIKFLIDIRADVLSPDATNSVVLRSLSNAIRDLIAPCFGIDMLQLDRVSWSSPGSLLQHVSEGEAVHPMRSWSDLKKRLGPYRRCFILLHPALPKKPLAILHVALTNEISNNIHTIITRNLSQSFDSETDGSRLADIGVEDIDRVNTAIFYSISSTQKGLAGIDLGQSLIKRALRELQTEIPSLQQHSTLSPIPGFRSWLLQQLRETERGRKTVLTDFNWSTALQLINSTKENPLGMLRSLLVDSSWMREEAKAKLMENPLMRLCAHYLFVEKRRGFALDSVANFHLRNGAMMWRLNWASDLSPRGLKNSFGLMMNYRYYVDACEKYSQLYAEKQHIESSEQIRLLSGVSNSSAASQISHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRK0</accession>
    <name>E9FRK0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="5">HIU hydrolase</shortName>
            <shortName evidence="5">HIUHase</shortName>
            <ecNumber evidence="5">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_230132</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="5"/>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90183"/>
    <dbReference type="EnsemblMetazoa" id="EFX90183">
        <property type="protein sequence ID" value="EFX90183"/>
        <property type="gene ID" value="DAPPUDRAFT_230132"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230132"/>
    <dbReference type="eggNOG" id="KOG3006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115536_1_0_1"/>
    <dbReference type="InParanoid" id="E9FRK0"/>
    <dbReference type="OMA" id="ENQNYHI"/>
    <dbReference type="OrthoDB" id="1453185at2759"/>
    <dbReference type="PhylomeDB" id="E9FRK0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="PTHR10395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00095">
        <property type="entry name" value="TR_THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="SSF49472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TR_THY" evidence="6">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600895-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX90183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="117" mass="13294" checksum="E606664087EE31C1" modified="2011-04-05" version="1">MASNYSPLTTHVLNTATGKPANGMQITLHRMKSDSTWEVLKEGKTNEDGRLTGLTSKEGFTPGMYKMYFDTSSYFKDMNIITFYPYVEVVFNIVNTNEHYHVPLLISPFGYSTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9FTC8</accession>
    <name>E9FTC8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase I subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_40279</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89662"/>
    <dbReference type="EnsemblMetazoa" id="EFX89662">
        <property type="protein sequence ID" value="EFX89662"/>
        <property type="gene ID" value="DAPPUDRAFT_40279"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_40279"/>
    <dbReference type="eggNOG" id="KOG3438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090381_4_2_1"/>
    <dbReference type="InParanoid" id="E9FTC8"/>
    <dbReference type="OMA" id="MRIQMYD"/>
    <dbReference type="OrthoDB" id="1398114at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA_pol_L_2" evidence="7">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX89662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="86" mass="9787" checksum="E6EB2E55EFFE5ADA" modified="2011-04-05" version="1">MKTFIFKGEGHTLGNAIRTIILKNPDVIFCGYTIPHPSENKLHLRIETKSISAIDALREGLEQLQNLSDHILKTFEVVVMKHLSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9FTT6</accession>
    <name>E9FTT6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_310484</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89587">
        <property type="protein sequence ID" value="EFX89587"/>
        <property type="gene ID" value="DAPPUDRAFT_310484"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_310484"/>
    <dbReference type="HOGENOM" id="CLU_577799_0_0_1"/>
    <dbReference type="OrthoDB" id="1742703at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="473" mass="48703" checksum="C04425DA5E3B05F7" modified="2011-04-05" version="1">MFQSGFSTMGPGGYGFPSHLHPSAGYINSISAMHSPHASMSMGYGTNPGVVPPTAAPSPAPSPAASSFMPVPPVPTMPTVIQQSGKQRRSSSTHRYTPIAPAPPSHTSNSTVAPSPSVTTPSTGYYNQHSAPTQPQVPIARPASQYLPPAQSPSHPVPSTATSSTTATAPSCSLAKLQQLTNGLADSASPHHTMTPPPNQTPPPPPPPSHLHGLGHGRDPYGYGVVPTPPPSAISSQQSYAKYYQGSVPSPIPVSSSPVAGLNTTSGVIHSSNNELASTHSSGGHNLNVSGHPGRSSSSSSTAAASSPSSTTGRNSNNSNLQQRQAPDAATQQRQAQIMQQTYSAMNLNGYRMSMAGMAGMPGMPGMPGMGMPSMSSMMAAQHQALNSASYITANPGFMNQSQLGVMNMHAHAAAAHAAQHPHASPHGHSAAAQAAQYQQVDQRTGTPAGMTYSTPYAYGIPQLPQLNGTMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9FU32</accession>
    <name>E9FU32_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_303246</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89539"/>
    <dbReference type="EnsemblMetazoa" id="EFX89539">
        <property type="protein sequence ID" value="EFX89539"/>
        <property type="gene ID" value="DAPPUDRAFT_303246"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303246"/>
    <dbReference type="eggNOG" id="KOG3614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026740_0_0_1"/>
    <dbReference type="InParanoid" id="E9FU32"/>
    <dbReference type="OMA" id="NPFNEIA"/>
    <dbReference type="OrthoDB" id="330667at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018209">
        <property type="term" value="P:peptidyl-serine modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="MHCK_EF2_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="4">
        <location>
            <begin position="416"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX89539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="668" mass="74191" checksum="467CCF4B08D85FF9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9FU64</accession>
    <name>E9FU64_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EOG090X0J63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EOG090X0J63</name>
        <name evidence="8" type="ORF">DAPPUDRAFT_303074</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CH-H</strain>
            <strain evidence="10">PA42</strain>
            <strain evidence="11">TCO</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for proper progression of late cytokinetic stages.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RASGEF1B.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCDC124 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR014402">
        <property type="protein sequence ID" value="SVE84021.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015010">
        <property type="protein sequence ID" value="SVE84629.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015634">
        <property type="protein sequence ID" value="SVE85253.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89492"/>
    <dbReference type="EnsemblMetazoa" id="EFX89492">
        <property type="protein sequence ID" value="EFX89492"/>
        <property type="gene ID" value="DAPPUDRAFT_303074"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303074"/>
    <dbReference type="eggNOG" id="KOG3223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069723_0_1_1"/>
    <dbReference type="OMA" id="RHPEKRM"/>
    <dbReference type="OrthoDB" id="1585903at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
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                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Basu M.K."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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    <sequence length="284" mass="31770" checksum="88C3025EEDC91E52" modified="2011-04-05" version="1">METVAAFFGGNPFATPIGQLIERATDASLSDENWALNIEICDMVNEQDDGPRDAVRAIKKRLQLNAGKNHTVVMHTLIVLETAVKNCGRRFHILVCSKDFVQELVKLIGPRNDPPTDLQEKVLTLIQSWSDAFQQYPELQGVTQVYQELKSKGIEFPMTNMDLMAPIITPQKSVYQRPPPADPQHAAPVDVSTLSAITLSGPQLAKLQHELSMVEGNMSVLSEMLAEMSPGQEKPADLELLRELYSTCRNMQQRLVELVDRVANDEITAHLLKINDDLNNLFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9FW00</accession>
    <name>E9FW00_DAPPU</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">DAPPUDRAFT_233876</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX89012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89012">
        <property type="protein sequence ID" value="EFX89012"/>
        <property type="gene ID" value="DAPPUDRAFT_233876"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_233876"/>
    <dbReference type="HOGENOM" id="CLU_2906327_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX89012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="62" mass="6666" checksum="062A5C7E35660728" modified="2011-04-05" version="1">MVVDGFLLYCMMPCRGSISEMCAGLLTDFTVQVVIEYVAWRTSAFPLAQGIAAANVLAAVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXI8</accession>
    <name>E9FXI8_DAPPU</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_305526</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88084">
        <property type="protein sequence ID" value="EFX88084"/>
        <property type="gene ID" value="DAPPUDRAFT_305526"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305526"/>
    <dbReference type="eggNOG" id="ENOG502SXGT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089443_0_0_1"/>
    <dbReference type="InParanoid" id="E9FXI8"/>
    <dbReference type="OrthoDB" id="1288675at2759"/>
    <dbReference type="PhylomeDB" id="E9FXI8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00718">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003239844" evidence="1">
        <location>
            <begin position="23"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="231" mass="26106" checksum="AE43B9EE1C719EF2" modified="2011-04-05" version="1">MKLRRSFRLLLFVAAIILGVESAKIHKKVRRSALSLPSGGTLSVTMDLIIPVVPLLNTTLTYLWFDLPLTFDLPTASALNELYSSFGMSSETSNDDESRISNELNHEFVEEQRANHDRRQVYKYAESFFQNFGFNGNACLKRAICELAEAPLGNHGLFGKIFDILFLPTESDFPQHEQNFINFTSLPPELHFLGNRNKDEYNDAYLKGRAASGCLTHFSACPISVFKLLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXK5</accession>
    <name>E9FXK5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_305705</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88255"/>
    <dbReference type="EnsemblMetazoa" id="EFX88255">
        <property type="protein sequence ID" value="EFX88255"/>
        <property type="gene ID" value="DAPPUDRAFT_305705"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305705"/>
    <dbReference type="eggNOG" id="KOG0508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020042_1_0_1"/>
    <dbReference type="InParanoid" id="E9FXK5"/>
    <dbReference type="OMA" id="ACFMTHL"/>
    <dbReference type="OrthoDB" id="252380at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="555"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="644" mass="72903" checksum="DB35CD02A199AD84" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXT4</accession>
    <name>E9FXT4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_305716</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
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        <property type="protein sequence ID" value="EFX88154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88154"/>
    <dbReference type="ESTHER" id="dappu-e9fxt4">
        <property type="family name" value="Carb_B_Arthropoda"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88154">
        <property type="protein sequence ID" value="EFX88154"/>
        <property type="gene ID" value="DAPPUDRAFT_305716"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305716"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_13_2_1"/>
    <dbReference type="InParanoid" id="E9FXT4"/>
    <dbReference type="OMA" id="HEEEYAG"/>
    <dbReference type="OrthoDB" id="992858at2759"/>
    <dbReference type="PhylomeDB" id="E9FXT4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005128570" description="Carboxylic ester hydrolase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="COesterase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX88154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="567" mass="61984" checksum="5849087834FC58AE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYS6</accession>
    <name>E9FYS6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_221551</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87588"/>
    <dbReference type="EnsemblMetazoa" id="EFX87588">
        <property type="protein sequence ID" value="EFX87588"/>
        <property type="gene ID" value="DAPPUDRAFT_221551"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_221551"/>
    <dbReference type="eggNOG" id="KOG3732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1367474_0_0_1"/>
    <dbReference type="InParanoid" id="E9FYS6"/>
    <dbReference type="OrthoDB" id="1093169at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070920">
        <property type="term" value="P:regulation of production of small RNA involved in gene silencing by RNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="129"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX87588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="200" mass="22141" checksum="2A8150A1ED46AE9E" modified="2011-04-05" version="1">MAEVSLGEPSAAQEKTFVSVFHELCTKFDFGVAMYNLVAEQGEPHSRTFLMNLTVDMLGISVEGIGLTKMQAKHDAAYKMMFQIRETYRAGGTLNSVPRVKLVSCCEWLEKCGTLKEDIPKPPTEPTLNPAGVLTEWCLTRLSNLPDYRVVRTSGPSHSKTYFMTCKLGDRVTEGEGKSKKAAKNVAAGKMLQILEDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZU9</accession>
    <name>E9FZU9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_43853</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87114"/>
    <dbReference type="EnsemblMetazoa" id="EFX87114">
        <property type="protein sequence ID" value="EFX87114"/>
        <property type="gene ID" value="DAPPUDRAFT_43853"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_43853"/>
    <dbReference type="eggNOG" id="KOG4120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042829_2_0_1"/>
    <dbReference type="InParanoid" id="E9FZU9"/>
    <dbReference type="OMA" id="FWPVLHL"/>
    <dbReference type="OrthoDB" id="205490at2759"/>
    <dbReference type="PhylomeDB" id="E9FZU9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="PTHR12159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="2">
        <location>
            <begin position="51"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX87114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="267" mass="30238" checksum="FB5DF337365EF797" modified="2011-04-05" version="1">MDSILPVEADAADGQPGKRKYTKSEHYKQRRRHDRFNGMTEEEVRSRTLPDHLASNLDVVIIGINPGLFAAYKGHHYAGPGNHFWKCLYLAGLVPEPMTADDDFKLMHFGIGFTNMVARATKGSADLTRKEIREGGRILLEKLQQYRPKIAVFNGKGIYEVFSGKKEFTFGKQPECIDGTNTFIWVMPSSSARCAQLPRAMDKVPFYSALKKFRDYLNGLIPEIDENEVIFNDPKIRAADDGTEISEHLKGTTSNHFICYFYSFNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9G019</accession>
    <name>E9G019_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C1q and tumor necrosis factor-related protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_221857</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87165">
        <property type="protein sequence ID" value="EFX87165"/>
        <property type="gene ID" value="DAPPUDRAFT_221857"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_221857"/>
    <dbReference type="eggNOG" id="ENOG502SWHP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_812011_0_0_1"/>
    <dbReference type="InParanoid" id="E9G019"/>
    <dbReference type="OrthoDB" id="169982at6656"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="SSF49842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240489" evidence="2">
        <location>
            <begin position="24"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="3">
        <location>
            <begin position="107"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX87165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="342" mass="38125" checksum="BB4558EE19AF117D" modified="2011-04-05" version="1">MAPLSTALFCIVIFAFTWSSCAAKSTLEEELQQLKESYVHLKQIVYVQNIQLKEKIVQLETKGAQLEELLRLKDQKHELGTLPSNATMRQGLATKMPTSCLDLKSLGHQFNGVYSVMRNKNDVFVQANTTIIFDEELVNVGGAMNASTGKFTATTTGTYFFNLVGLAWFPESSYRLVLYIALKLNGKDITYCHANAFDLKGTWKTFSLPSTLRLKKGDQIWFEINQLSTGVYLNGRGHTQFTGGLLEEELRKVGDLLFDEVVCTVALSLAGVFVSNYQPDGNYNQFHLFSSSNYFRNYDALPPTGKAPSRVSPDINQVTMLALGSFIACLKELKGKINDFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E9G084</accession>
    <name>E9G084_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DAPPUDRAFT_43617</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Postsynaptic cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87443"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_43617"/>
    <dbReference type="eggNOG" id="KOG3645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018074_1_0_1"/>
    <dbReference type="InParanoid" id="E9G084"/>
    <dbReference type="OMA" id="QHAKNKD"/>
    <dbReference type="OrthoDB" id="381858at2759"/>
    <dbReference type="PhylomeDB" id="E9G084"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated cation-selective channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005231">
        <property type="term" value="F:excitatory extracellular ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904315">
        <property type="term" value="F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050877">
        <property type="term" value="P:nervous system process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="PTHR18945"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="SSF63712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="SSF90112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="234"/>
            <end position="255"/>
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            <end position="287"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
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            <end position="320"/>
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        <location>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1 2">Belongs to the importin alpha family.</text>
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    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
    <sequence length="470" mass="52010" checksum="CA85793ED6396524" modified="2011-04-05" version="1">MNLNHVGINNGDENEIFTATHAVTILTRNFYPVIDILINANVVPKLVEFLSRVNNPDLQLESAWALANIASGTSDQIEAVVSAGAVAGFISLLGSPHPVLVEIAVWTLGNIARNDLELTNHVIEQGIIEPLLIFINKPDISDHFSCRSLFLAVSNIFRHLCRYLNPTVPTVRQLLPALFHLIYKNDKYVLAKACMALCYLTVTNDVVQEVVDAGVVPRLVFLLDNNDFPVNFPALRTIGNIVTGIQTTVAGAYPLLAKLLMVNSSTKTFWYEATVFASRIADCNAAETQDLITSNVILPLEDVLIQGDFKRQEETALVISHITLGGNVIKTATLFKFDFVSLCSLMCILLCTLLCTLLKATEPKTIVVVLDGLALILEASKKMGDLEKVSLHVKKCGGLDCIKALKSNENVEIHHKSLAILERYFPTDVIFFHFYGFGFLSMTTTTRFSVCVDNLTITKFLTFDLIWFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Arnold G.J."/>
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    </reference>
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                <person name="Basu M.K."/>
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                <person name="Choi J.H."/>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX84069.1"/>
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    </evidence>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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    </evidence>
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        <source>
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</entry>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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                <person name="Geiler-Samerotte K.A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX81591.1"/>
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        <property type="protein sequence ID" value="EFX81591"/>
        <property type="gene ID" value="DAPPUDRAFT_317198"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX81591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="332" mass="37144" checksum="D8C9A21C69358BAF" modified="2011-04-05" version="1">MTEQGSRPAPEEGEEEEATLTADRQQNQTSRTGAWIKEARTKRRTLRQQITTTGRRIETLVQSRGSRGAILGLIRHFDELLLRASHLQTELTSVEDDEEAERQDNLHLTYVTRVGETTEYARSYLVSREGEAASVVGLGGNVPAAPAVSPSEIRRREQARLEEIANAQRRCDDAREQANRVWEECEAAQAALGQLSGRPAEPDQHSSVSQQLPDANPLANEWLARQRRINNISNLNNNNQETPDDWIDQYSAGLLPPISNKLSARSAVEKSKKISQKTQRQVSSYFQPITNVTCVESVNQLQAFNSAKIQTSNEEKENQQQVVLSPASDGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9GF86</accession>
    <name>E9GF86_DAPPU</name>
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        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
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        <name evidence="2" type="ORF">DAPPUDRAFT_102059</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Cladocera</taxon>
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            <taxon>Daphnia</taxon>
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    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732542">
        <property type="protein sequence ID" value="EFX81853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81853">
        <property type="protein sequence ID" value="EFX81853"/>
        <property type="gene ID" value="DAPPUDRAFT_102059"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_102059"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_39_4_1"/>
    <dbReference type="InParanoid" id="E9GF86"/>
    <dbReference type="OMA" id="CPRIGSK"/>
    <dbReference type="OrthoDB" id="1647753at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
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        <property type="entry name" value="Exo_endo_phos_2"/>
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    </dbReference>
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        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="138"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="378" mass="42671" checksum="FE77843E1BED32D9" modified="2011-04-05" version="1">MPWAECRLLFLSLRDSLLPPLSPSATATILRLSLDKGSSLTPIASKPYVIHHHLFTFDLDVLAITETWLTPEHGDEILANTIPEGYVGIHVPRVGRRGGGIAVIHRSTICVNRLPIVFESPFFEHLAISLTVNTVFVKIAIIYRPPSVSCPKFLSDFSDYLEILSVGAGKLLILGDFNIHVDDNACSIGRKFLATLDSFGLCQHVSTPTYVSGRLLDLVLSRLADNFVMHCYTSDLISDHFAVHTLVKVHRLVRPQKTVVFRRLKSIDREAFVSDLLASSIFIDPENDTASLLAQYNTDVRAVLDKHAPLITKRLTVRPDNPWDCEEIRTCRRSLRRWERKYRARGLTIDRECLTNAREALKNLIFEKKSSFITQKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9GGI7</accession>
    <name>E9GGI7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_224273</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732543">
        <property type="protein sequence ID" value="EFX81487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81487"/>
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        <property type="protein sequence ID" value="EFX81487"/>
        <property type="gene ID" value="DAPPUDRAFT_224273"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_224273"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_7_0_1"/>
    <dbReference type="InParanoid" id="E9GGI7"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="PhylomeDB" id="E9GGI7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240985" description="Peptidase S1 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="25"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX81487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="264" mass="28658" checksum="AA89AE17FE919B78" modified="2011-04-05" version="1">MVYALVFTIFVTFVSGAPNEELGRIIGGNLSSSTEQFPYVVSISWQGQPMCGGFIYNDQWVVTAAECVHGKNPGELKVTIGTLSLVIPDPGEQLIGVYKLIVFSQFDPVSLKHNIALIKLNRQIEIGPTAHSIRYGEIDELATPWDAYIVGWGALYDGGPQPTKLRWAPIDDLAADCGIFSIDEFQQDSMICAGSTTGTISPCQYDEGSPLTQITNSTGISEEIIVGIMSKNKGCADPSLPTIYTRLSTYNSWILQTAGPQLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9GHR3</accession>
    <name>E9GHR3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_102851</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732545">
        <property type="protein sequence ID" value="EFX81007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81007"/>
    <dbReference type="EnsemblMetazoa" id="EFX81007">
        <property type="protein sequence ID" value="EFX81007"/>
        <property type="gene ID" value="DAPPUDRAFT_102851"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_102851"/>
    <dbReference type="eggNOG" id="KOG1027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_579040_0_0_1"/>
    <dbReference type="InParanoid" id="E9GHR3"/>
    <dbReference type="OrthoDB" id="1019877at2759"/>
    <dbReference type="PhylomeDB" id="E9GHR3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="PTHR13954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX81007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="472" mass="52836" checksum="E495DAF8BE484DF9" modified="2011-04-05" version="1">MDNKRWSTSRSIKWDENDILGRGCEGTVVFSGHFDGKEVAVKRLLLTNLQLVERELEALLHFSHPRILQLYHVERESPFLRLALELCVATLDDYCKEKYTGPMPEEMDALKQMLEGLAFIHSCKYVHRDVKPNNILISQSGGLKIADFGFCKPVRGIDSFSMSNAGVGTGGWMAPELLKSIADQESGGSPASYATTAVDVFPLGCVFYYFITKGVHPFGNTTLRNGNILMGKHNLSKLGKRYILRALIKEMISPNPEQRPKLDEVLTRPMFNTTESEELLKDDTKFALWLKHIKSQFASTKKRRKQPFQSDMTNDECDSIVRAVPFQATNARIPVFQAITNLQVVNEESSQTPEPLEGLKMSTRRRAQTDSNSVTHRLQVSSAPANWQRTVPRGRRNWSEWSEFLSNGENVPEPVYNTRLRSVASLSNLDPGIASSADSLSNLSITSSTPSKTSSLLSLSRSIIGDLFNKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIB6</accession>
    <name>E9GIB6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_318274</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732546">
        <property type="protein sequence ID" value="EFX80649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80649"/>
    <dbReference type="EnsemblMetazoa" id="EFX80649">
        <property type="protein sequence ID" value="EFX80649"/>
        <property type="gene ID" value="DAPPUDRAFT_318274"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_318274"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_5_1"/>
    <dbReference type="InParanoid" id="E9GIB6"/>
    <dbReference type="OMA" id="NHACNIV"/>
    <dbReference type="OrthoDB" id="1166960at2759"/>
    <dbReference type="PhylomeDB" id="E9GIB6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030707">
        <property type="term" value="P:ovarian follicle cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="term" value="P:small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="PTHR24072"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX80649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="184" mass="21005" checksum="43699BF7FDB2A54B" modified="2011-04-05" version="1">MNRIRPLKITVVGDGMVGKTCILIVYTKKEFPEIHVPTVFDNFSDTIEVDGFPYNVTLWDTAGQEEYKNLRILSYPNTDVFLLCYAVNIRSTFENIITKWIPELKHYCPHTSIVLVGTKVDIRQEGQSNCVSTTEGRELSKKFQLNSFLECSAKTQENVIQVFEEATRVALNKPKSKPHKCSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GK83</accession>
    <name>E9GK83_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_103770</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732549">
        <property type="protein sequence ID" value="EFX80106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80106">
        <property type="protein sequence ID" value="EFX80106"/>
        <property type="gene ID" value="DAPPUDRAFT_103770"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_103770"/>
    <dbReference type="HOGENOM" id="CLU_1416464_0_0_1"/>
    <dbReference type="OrthoDB" id="1535664at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX80106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="192" mass="21897" checksum="ABCD8E225CCD2CB7" modified="2011-04-05" version="1">MEPTEFDPKWWSLKFKGPGLRYEVALRIRSGHIMWVNGGLPCGKWPDLRLARNALTVFSREDTATSFTLICQRRRPERSRKIGYNVVPKNKISRQWIYEILEQPPTFMSLAEKSTLSCSLRLLHAAIATASQKDLPEGDAAKGIGQMVKSIKQVLESKPEVKKSNPPERILNDIKEDWINYRKKLGIACGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9GNA5</accession>
    <name>E9GNA5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_245407</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732554">
        <property type="protein sequence ID" value="EFX79065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79065">
        <property type="protein sequence ID" value="EFX79065"/>
        <property type="gene ID" value="DAPPUDRAFT_245407"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_245407"/>
    <dbReference type="HOGENOM" id="CLU_680199_0_0_1"/>
    <dbReference type="OrthoDB" id="1300981at2759"/>
    <dbReference type="PhylomeDB" id="E9GNA5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090630">
        <property type="term" value="P:activation of GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="SSF48350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX79065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="405" mass="43060" checksum="1340A2346E3B4150" modified="2011-04-05" version="1">MLASNLGIVFGPTLLRTTEGSATLSSLVDTVHQTKVIELLVGHADTIFGPPDPALTSLTVASSSSSASASAALMASSSPAHRLSAQSPKVAEQQESPAVVAPGSSSSSSSTTSTASSLLSKVPVVRSISFLEKHCLKSRDAADRDHAAINAATIISKPADRRSQQHLAGELREEVLLSGYARRQNAQPFDRHRPPVRRGLLGAISDDDLPDFLLPNDSSKIRKLPGYLRSGSAPKIFKSSLKDYQGLKGVKPSCVNPFMDSSIDSDHSWESHSTGSSGRGTQHSDQGSLGSAQRSGLTKRTIENWTTTIFIRALKHLFWETLRANRGHSGIGPKLTGGLLGDFPHVGLVILPLGHVVITTAMGWTTMSEESVTVAAMLPTAPVWSHSTECANDLSMDNRTDGTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9GNC4</accession>
    <name>E9GNC4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_245429</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732554">
        <property type="protein sequence ID" value="EFX79054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79054">
        <property type="protein sequence ID" value="EFX79054"/>
        <property type="gene ID" value="DAPPUDRAFT_245429"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_245429"/>
    <dbReference type="eggNOG" id="ENOG502T9EC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_708363_0_0_1"/>
    <dbReference type="InParanoid" id="E9GNC4"/>
    <dbReference type="OMA" id="FMENCIN"/>
    <dbReference type="OrthoDB" id="1703789at2759"/>
    <dbReference type="PhylomeDB" id="E9GNC4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX79054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="390" mass="44320" checksum="C65768BCB4DECBAA" modified="2011-04-05" version="1">MYEEALSSMTAIPIDITLEQTINADAAGRFSAGIASSTNSLAARQRWAMVRYLQTSVVSYLLDKVGMSTKDDASRESHPSRIKKDKKDFDSVVEFMENCINPFSSEAQDLVNISRGKVASEETTRFLLNVMSNGEKMRDEFIQNFCNDPESFERPIRRQRLQTFASEGVRIKKTRTDGKVQELTMERDLFGRILVIALEEKVDIRNVLEYPLTPVPLCFSHLDGHMNKTNKAKTFKILEDRVKHQPPTNIDVVIIDGFFFLHLCPDLPSSFGKSSRHILQRVCAFRAKTIHLIFDRVTSPSIKDMEQDKRTDSDRDVPFKIAGDNQLRPTDFIKALRNNNFKRELGDMVPTTIEDIILDSSNEEEKDEDATDVSSDEADDESDCSLSDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9GNF2</accession>
    <name>E9GNF2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EOG090X0NBY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">EOG090X0NBY</name>
        <name evidence="2" type="ORF">DAPPUDRAFT_319968</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CH-H</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL732554">
        <property type="protein sequence ID" value="EFX79018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR014445">
        <property type="protein sequence ID" value="SVE84064.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79018"/>
    <dbReference type="EnsemblMetazoa" id="EFX79018">
        <property type="protein sequence ID" value="EFX79018"/>
        <property type="gene ID" value="DAPPUDRAFT_319968"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_319968"/>
    <dbReference type="eggNOG" id="KOG3456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083053_1_0_1"/>
    <dbReference type="OMA" id="RFYNSHV"/>
    <dbReference type="OrthoDB" id="1641902at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005747">
        <property type="term" value="C:mitochondrial respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CHCC" evidence="1">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX79018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="SVE84064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="130" mass="14438" checksum="BC5CFE03E6872BDB" modified="2011-04-05" version="1">MATSKFRLVQILGKQLKQTPIRHEIPFSTAPKVLKEAAAADLPTHTGQKWDESDFRLARFENASKQVNTRFAIDLIAQVPPKETKSRIVSCNGGGGPLGHPQVYINLDKPGNHTCGYCGLRFVKPDDHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPM6</accession>
    <name>E9GPM6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_105145</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
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        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
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        <property type="entry name" value="TET_fam"/>
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        <property type="entry name" value="Znf_RanBP2"/>
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    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
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        <location>
            <begin position="238"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX78409.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="372" mass="39866" checksum="D859264FE7EC61E1" modified="2011-04-05" version="1">MLNMNPFNYFISFRFIVSNADALFRDLSTDLICKQFLLPKGPRKTYRQLYQKAKHAWADRAFCKINKGIHKGREEGVQAIVAAMAAVSPTAAVAATAVAAAAAALPAPAPAAALPADDFVESSSSFHSPTPMEIKDGGAGRDCLDGGAGRDCLDGGAGGGGGGGGRRGGRVGDWLCVPCDVWNFVWRTVCHKCLAPRNVSENDTMEWETSSYPSEASSGAEAPTTFRTVFFRTRYNIESSQNLTNVLEAVGLGEYSALFSSNHIDVEMFMTLSAEELFFLGVQSFGARRMGDALETGCVFRAAYGTSCGALYATSAEHPGAFPMTTGWNGNSHNPIHQPMQTHQRSLRGPNPLAFLKRSFSGPGSIWNLQGP</sequence>
</entry>
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    <accession>E9GPP8</accession>
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            <fullName evidence="2">C1q domain-containing protein</fullName>
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    </protein>
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    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732557">
        <property type="protein sequence ID" value="EFX78423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78423">
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        <property type="gene ID" value="DAPPUDRAFT_320383"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_320383"/>
    <dbReference type="HOGENOM" id="CLU_068539_1_1_1"/>
    <dbReference type="InParanoid" id="E9GPP8"/>
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    <dbReference type="PhylomeDB" id="E9GPP8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular space"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="C1q_dom"/>
    </dbReference>
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        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="154" mass="17514" checksum="CA20CD2699D80259" modified="2011-04-05" version="1">MIGFEDVKSSPTYFYVQIFNLSFDQPNVPIPFDTARLKVGGSMNLQTGIFTVPRKGKYFFSASGIGFILASSARFWVDIHIMRNGNRIGSSSPDDTANFRQWEQFSLQSTLNLQPGDQIWWEIGYMNAGFKISHNGFNHFTGFLLEEEITHSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPT1</accession>
    <name>E9GPT1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DAPPUDRAFT_305162</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="200" mass="22618" checksum="5201A0CB69B1E58F" modified="2011-04-05" version="1">MLSEYPNQSSARWRDESPALFMMQLEQKVFALSHFLYLNRQHHQRFRSNPDQDKVATILRVWVLYLLLSPKTSSILKSSCTESISVAVHFSISHPIINFTCDIISRTAFVTTSTSTTHHCIKLETDVLLCLLHIDEVPRPLLRIAEDGITDITIKANDLLSRELGALTHVTVSVLVTEKLIDSCSRIFSGVAICTLPQKR</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX77260.1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="125" mass="14146" checksum="7D08145C4E6A7E77" modified="2011-04-05" version="1">MDKRKIYPVKKIIGVGIIPVEDTWYKVKWEGYKQATWVYDGDCDGCPDRIKEFLDGYNGEPVPLLKFNFHMNQLASAELMDGFASLIFIILAFNNHLTSMGMAIKHEPPGGHDLQNSECLLGPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTN2</accession>
    <name>E9GTN2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="3">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:chitin binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
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        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="CHIT_BIND_II"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240634" evidence="2">
        <location>
            <begin position="20"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="209"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="352"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX76479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="478" mass="51667" checksum="7C79A46307AAC754" modified="2011-04-05" version="1">MAPTFLFIVLAALVHFSSAASNNFPSFRQVRRINIRKQNGRQTPAPFNCVKAGFFGDPKDCNRFYRCVDYYGNEAQFTLFEFVCAEGTIFDESLSVCNHPHAVNPPPACLATTSLVTPTAPTTAPTDAPTAAPTAPTVPTTEFAPDVLPVDPVTTTTAAPVPEPITAAPAPVTTTVAAPATTTVSSGESELTPAITPIVPPPTDAAPFMLTCNDDKFHRHPVRCDLYYKCVWTELAFSVDLRACPPGQHYDEASGTCKSPGRTTACVFATLPPTGVVTTVPTVTTTVATEAPPAVPTTAVATEAPAVVPTTTVATEAPVTAAATTTALPAVETTATTAPSVPAQYTLAPGSLYDCKMPGHYPYQLDCIRFYRCFEIEARVLKGLLYRCPIDYAYSTVTERCVRQNTLPACDRNGIRLPMDFPVPLIPLEDTTMVLLEDFDSFFGNPNYFYIPRRKIKTNPQSSRIRNKPQPQPKNKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9GWD1</accession>
    <name>E9GWD1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_107218</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX76084.1"/>
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        <property type="gene ID" value="DAPPUDRAFT_107218"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0071040">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="169"/>
            <end position="262"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="262" mass="28534" checksum="8100B67219C32965" modified="2011-04-05" version="1">MPLATLQHHGQPVAIPKMMPTPLDQDTEDPLYCTHDLTHSQDIRDDLPTLLNPQTIESMASRSEEFGVLITVKEFPQALIFAESAQPGIVTNVSTNFVSPCTRYIFVRALKSAEEAAEAQRVEKLRQHFMEEVAYSTPDAQRESEATEEEAEAVAVAVVPAKKKKLALKPQGLNKKKKKVGSSKRVTATPETSVIPSNTSSPSKKSADAVVPSASKSPNPATSKRPNPETSKSPNPATSKSLNPETEPKMNCLCVDRPPRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9GWX5</accession>
    <name>E9GWX5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar complex protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_322760</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732571">
        <property type="protein sequence ID" value="EFX76039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76039"/>
    <dbReference type="EnsemblMetazoa" id="EFX76039">
        <property type="protein sequence ID" value="EFX76039"/>
        <property type="gene ID" value="DAPPUDRAFT_322760"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_322760"/>
    <dbReference type="eggNOG" id="KOG2256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011272_1_1_1"/>
    <dbReference type="InParanoid" id="E9GWX5"/>
    <dbReference type="OMA" id="FPLRFHC"/>
    <dbReference type="OrthoDB" id="1194328at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:Noc2p-Noc3p complex"/>
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        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:histone binding"/>
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    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0035067">
        <property type="term" value="P:negative regulation of histone acetylation"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
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    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="PTHR12687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="629"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="659"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="678"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="728"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX76039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="765" mass="87320" checksum="85E601054A1BCFE1" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E9GXL7</accession>
    <name>E9GXL7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DAPPUDRAFT_55650</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732573">
        <property type="protein sequence ID" value="EFX75680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75680"/>
    <dbReference type="EnsemblMetazoa" id="EFX75680">
        <property type="protein sequence ID" value="EFX75680"/>
        <property type="gene ID" value="DAPPUDRAFT_55650"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_55650"/>
    <dbReference type="eggNOG" id="KOG3643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010920_1_6_1"/>
    <dbReference type="InParanoid" id="E9GXL7"/>
    <dbReference type="OMA" id="IRYKWNA"/>
    <dbReference type="OrthoDB" id="480926at2759"/>
    <dbReference type="PhylomeDB" id="E9GXL7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005231">
        <property type="term" value="F:excitatory extracellular ligand-gated ion channel activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:1904315">
        <property type="term" value="F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902476">
        <property type="term" value="P:chloride transmembrane transport"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050877">
        <property type="term" value="P:nervous system process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002289">
        <property type="entry name" value="GABAAb_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
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        <property type="entry name" value="PTHR18945"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01160">
        <property type="entry name" value="GABAARBETA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="SSF63712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="SSF90112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Neur_chan_LBD" evidence="13">
        <location>
            <begin position="18"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Neur_chan_memb" evidence="14">
        <location>
            <begin position="232"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFX75680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="499" mass="56976" checksum="F4BE1DDCF70F8FDD" modified="2011-04-05" version="1">MFLYISLTTCSSIQNNVTAILDKLQRGYDKRVRPNYGGPPVEVGVTMFIISISSVSEVQMDFTTDFYFRQYWKDPRLAFDRLPGVERIMVSTEYLKNIWVPDTFFANEKSSYLHMATTSNEFLRITHLGEINRSIRLTITASCPMNLQYFPMDRQLCSIEIESFGFAMSEITYHWLGGKKAVDVSPDVQLPQFHVLGYRQGYRVEMLTTGNYSRMSLEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRQATPARVSLGVTTVLTMTTLMSSTNAALPKISYVKSIDIFLGTCFVMVFASLLGKYATVGYVEKRIRLRKTQYQLMQKLVESRKKTVTMALDSAEMEHAPRQTRINIRNVVVFKKCCYTQQEVRFLMGPHGKAMPIQHHETSGQQHQHHHPMMPPSAVGCQAVVNNSSSSSSSAMIINGPRIDEEATAVMIPPGKDLNKLYGFTPSDIDKYSRVVFPVCFICFNLMYWIIYLHISDVVADDLEFINRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9GXQ8</accession>
    <name>E9GXQ8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_306670</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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            <text>a ribonucleotidyl-ribonucleotide-RNA = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA</text>
            <dbReference type="Rhea" id="RHEA:67796"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ENDOU family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.-" evidence="6"/>
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        <property type="protein sequence ID" value="EFX74601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX74601">
        <property type="protein sequence ID" value="EFX74601"/>
        <property type="gene ID" value="DAPPUDRAFT_347698"/>
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    <dbReference type="eggNOG" id="KOG2849">
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    <dbReference type="OrthoDB" id="823332at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="XendoU"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR039787">
        <property type="entry name" value="ENDOU"/>
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    <dbReference type="InterPro" id="IPR037227">
        <property type="entry name" value="EndoU-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018998">
        <property type="entry name" value="EndoU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439">
        <property type="entry name" value="PTHR12439"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF142877"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
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    <feature type="chain" id="PRO_5026377529" description="Endoribonuclease" evidence="6">
        <location>
            <begin position="20"/>
            <end position="291"/>
        </location>
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    <feature type="domain" description="XendoU" evidence="7">
        <location>
            <begin position="31"/>
            <end position="289"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010168"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX74601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="291" mass="31678" checksum="DCC281ADB379FF85" modified="2011-04-05" version="1">MKCIAVMAVCVISALHVKANAVERATVTDAELQALSQQLHIDDVNAVQGIVFNMQSTTTSGSTTGKAPLPLFSSVPAGAFSGPTVSKLLALFDNYDENCKVTEVITAEEQTENDAFLDAILGTSVMQQAHQFLVSKGLADSSVAVFKEYLRQIWLGQYNRGGGYQSSSGFEHIFLGEKDNTTIQGYHSWFKYYRDEQAGKINYLGYLHNINLGVSSVIDLPMSWNGLYKSISSISISGSPEIELALATVCFLARPNAKCPLYGANATPYAYQTYTLTYNGKTYVGSAYPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9H1A3</accession>
    <name>E9H1A3_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_108936</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732583">
        <property type="protein sequence ID" value="EFX74408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX74408"/>
        <property type="gene ID" value="DAPPUDRAFT_108936"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_108936"/>
    <dbReference type="HOGENOM" id="CLU_1316613_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="209" mass="24010" checksum="1297A7CBD9752C4E" modified="2011-04-05" version="1">MEMMMNQPKNAGYRKTQQEEEEEEENLSVGDDTKRIVQDDDDGMAIVPTYEEKTRQESAAQARKKRHCQPLNQCVCLSVRLSLLDPQSSWPKKKTTKNDDQHVHTWPGQYTKRLSKGVRECVDDDFSKKPKRAPPNQEEEKDEQVDGRKQVAYEAYDEDSPDDKARNANEHLGRHFAGGGGTLVDHHRHPQQQQTQCTRQHNNNNNTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9H1C0</accession>
    <name>E9H1C0_DAPPU</name>
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        <submittedName>
            <fullName evidence="5">Trypsin</fullName>
            <ecNumber evidence="5">3.4.21.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TRY3</name>
        <name evidence="5" type="ORF">DAPPUDRAFT_347764</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.4.21.4" evidence="5"/>
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        <property type="protein sequence ID" value="EFX74419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74419"/>
    <dbReference type="MEROPS" id="S01.035"/>
    <dbReference type="EnsemblMetazoa" id="EFX74419">
        <property type="protein sequence ID" value="EFX74419"/>
        <property type="gene ID" value="DAPPUDRAFT_347764"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_347764"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_7_0_1"/>
    <dbReference type="InParanoid" id="E9H1C0"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241430" evidence="3">
        <location>
            <begin position="20"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="39"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX74419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="280" mass="29820" checksum="058D309209F1D442" modified="2011-04-05" version="1">MAKLVAVIVGAICVQCFFALPSPGRNDLVWRRKAATPLIVGGEEALPNEFPFMVSMQSLAVGGTYNHRCGGAVINERWVVSASHCTENALVGATRIAAGEHSLSTTSGFEQFSDVEMFVMHPNYDTVTLENDIVLIKLITPLDFSSGKVSPISLPAMGQETAAGTNVTVTGWGNLEFNNPNRPDVLNKVGIPTVSDLECRRSYGPIDMFDSFICAGVPEGGLDSCNGDSGGPLFTSDPQQLIGIVSWGKDCALPGYYGVYTEVSYFSDWIAATIAAADAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9H4U2</accession>
    <name>E9H4U2_DAPPU</name>
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        <recommendedName>
            <fullName evidence="6">CLCA domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="7" type="ORF">DAPPUDRAFT_253437</name>
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    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CLCR family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732592">
        <property type="protein sequence ID" value="EFX73295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX73295"/>
        <property type="gene ID" value="DAPPUDRAFT_253437"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_253437"/>
    <dbReference type="eggNOG" id="ENOG502QRRD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_243502_0_0_1"/>
    <dbReference type="OrthoDB" id="685640at2759"/>
    <dbReference type="PhylomeDB" id="E9H4U2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013642">
        <property type="entry name" value="CLCA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08434">
        <property type="entry name" value="CLCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1037"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1427"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="domain" description="CLCA" evidence="6">
        <location>
            <begin position="20"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1064"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1203"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1245"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1365"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1203"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1245"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX73295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1622" mass="178454" checksum="4A0022C57F873029" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5X0</accession>
    <name>E9H5X0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_325830</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732595">
        <property type="protein sequence ID" value="EFX72864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72864"/>
    <dbReference type="EnsemblMetazoa" id="EFX72864">
        <property type="protein sequence ID" value="EFX72864"/>
        <property type="gene ID" value="DAPPUDRAFT_325830"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_325830"/>
    <dbReference type="eggNOG" id="KOG1801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567743_0_0_1"/>
    <dbReference type="InParanoid" id="E9H5X0"/>
    <dbReference type="OMA" id="SQANIIC"/>
    <dbReference type="OrthoDB" id="1900840at2759"/>
    <dbReference type="PhylomeDB" id="E9H5X0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_11" evidence="1">
        <location>
            <begin position="233"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX72864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="481" mass="53934" checksum="FE3D073CB6485D1C" modified="2011-04-05" version="1">MFKDETFPILNAVQGKGYKSLPELSLIPVGSAYSTLEDYCSTFTSLILHEVWATLCENVGTGESQSLTSLIHPDPTFCNGFTLLRCEALSPTRITNIDLFSITFNTSRQKPPKKIFAVAEHVRYRSWEIGEIDPRLLKTCQDPNIPITSFVLRILMYHVPPNLGSIFTVTRISRLNTVFKQIIQIAELARSPLCEVILHPSDYEDAFKLDAVLDDNHAFLNPIQYKAVASITKEVSSAEREPKVALLQGPPGTGKTRVIVEMIKRVRCMHYETTGCYPCILVCAPSNNAIDEIANRLMNEIDSKYDIVRIGVPATMNPDVVRISLDKLSGGKLRDDAAKTTSSESRYLLTLKAESNTLQRKKKKLVAAILNANKNGSSDEAQMIEKKLAKLQVDIDKVERSYQDRFLTHLELLNTQNNLRAMRQKVLSQANIICSTLNSCRSKEMEQLFLEPASSKRFLCCIIDDRPSVPSQNLSCRSPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9H843</accession>
    <name>E9H843_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_326561</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732603">
        <property type="protein sequence ID" value="EFX72005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX72005"/>
        <property type="gene ID" value="DAPPUDRAFT_326561"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326561"/>
    <dbReference type="HOGENOM" id="CLU_1779330_0_0_1"/>
    <dbReference type="InParanoid" id="E9H843"/>
    <dbReference type="OrthoDB" id="1114912at2759"/>
    <dbReference type="PhylomeDB" id="E9H843"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX72005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="146" mass="16659" checksum="D5F63E809D027AFE" modified="2011-04-05" version="1">MSHKRKKDYKAVFGKLIEIIEDPISGYPKVEEIMSDFEAAVWVTLKELLPQSKMKGCGFHLNQAMFKNMKKIGLGPIYNKDDATRTVCRQLMSLNLLPAEKISKQFYVIVEENGNGSNIRYGHQQHGRCLWNIVAQITMQKGTTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9U6</accession>
    <name>E9H9U6_DAPPU</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein DpuGr20</fullName>
        </submittedName>
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    <gene>
        <name evidence="5" type="primary">DpuGr20</name>
        <name evidence="5" type="ORF">DAPPUDRAFT_346850</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EFX71547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71547">
        <property type="protein sequence ID" value="EFX71547"/>
        <property type="gene ID" value="DAPPUDRAFT_346850"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_346850"/>
    <dbReference type="HOGENOM" id="CLU_058520_0_0_1"/>
    <dbReference type="InParanoid" id="E9H9U6"/>
    <dbReference type="OrthoDB" id="731934at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="PTHR21143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX71547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="450" mass="51202" checksum="1B33B80428343653" modified="2011-04-05" version="1">MSGTANVCEVRTGRTDIFCRMLCVELILSIGQQHAHQCVFIYLLVQVVPFLSGRSRLPEMLKIETSLWPLIVWMRIVGFHMGPSRKKSGSPNRHRYSVCLLMTGSLMLLSTVALHCTSFVRSFLKFRANGMAQHNGTTANLTTANRLNVGIEHLNYTCVLIGVHTTFFFVSLTSNWTGLWDSLQLIEANLKFNCTFYRKCQKCVVIGFVILFVDFASQLFISIHSFYWDMGLMSPLAIVLANISRTTISSVFLLFFVLARVITLVFQGLNEQIVHLDEVEQVPQCYSVSRILNVRLEKWRRNHTLACELVEMVNKCFGFVMLITLVNVFVSFVTTSFEIVRSMEDDETLPFLLVFIFVKKSILLTIMFYEPYRLQAETGRTASSLRRLHPFTADLFTQIKVNTVVMEVSHACPKITAIEFFDVNLKLLPTLIGSTLTYVAILHQVASHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9HA50</accession>
    <name>E9HA50_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="5">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732610">
        <property type="protein sequence ID" value="EFX71368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71368">
        <property type="protein sequence ID" value="EFX71368"/>
        <property type="gene ID" value="DAPPUDRAFT_327230"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_327230"/>
    <dbReference type="eggNOG" id="ENOG502S4KI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075165_4_0_1"/>
    <dbReference type="InParanoid" id="E9HA50"/>
    <dbReference type="OMA" id="AYSAYPK"/>
    <dbReference type="OrthoDB" id="1583175at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012655235" evidence="3">
        <location>
            <begin position="16"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX71368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="166" mass="18421" checksum="C896F82E18FF9389" modified="2011-04-05" version="1">MKFFVLAAVFAVAAASSYKAAEYAPKYEAKYEEVTYAPQPYSFEYDVQDKESYNDFVHSEKSDYNVVTGSYRVALPDGRTQIVTYKADASGYNADVKYEGEAQYPEEPKYKAASYPAPAYSAPEYKAPAPAYKAPTYSAPAYKAPVYTAPAYKAPAYKPAPAYPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9HA94</accession>
    <name>E9HA94_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F2_3" evidence="6">
        <location>
            <begin position="22"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F2_4" evidence="7">
        <location>
            <begin position="140"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX69925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="542" mass="62349" checksum="76FE96EF78F6A616" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HFS4</accession>
    <name>E9HFS4_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX69371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69371">
        <property type="protein sequence ID" value="EFX69371"/>
        <property type="gene ID" value="DAPPUDRAFT_300945"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300945"/>
    <dbReference type="HOGENOM" id="CLU_1549180_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX69371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="173" mass="20525" checksum="7D13D3485781FC29" modified="2011-04-05" version="1">MKEIKEQLGFQPRDVYSHDVSLNSGGVDEVNNISRMSHECNRYLYREHEKNFEDFRDYNEQNGSPEVITRVITKHYEHSVGEIGLLRMEKEGKYADRYKTKGYQHNFYTGSLKQPTNLYLSGFISNYNGQQASNFLMRNNDLRRMKRTDARRRATNVPFVSGRKFETFFLDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
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    <name>E9HG11_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11333"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TENT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="GL732638">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69340"/>
    <dbReference type="EnsemblMetazoa" id="EFX69340">
        <property type="protein sequence ID" value="EFX69340"/>
        <property type="gene ID" value="DAPPUDRAFT_13279"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_13279"/>
    <dbReference type="eggNOG" id="KOG3852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008115_2_0_1"/>
    <dbReference type="InParanoid" id="E9HG11"/>
    <dbReference type="OMA" id="CCENPTM"/>
    <dbReference type="OrthoDB" id="612201at2759"/>
    <dbReference type="PhylomeDB" id="E9HG11"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:RNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012937">
        <property type="entry name" value="TET5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974">
        <property type="entry name" value="PTHR12974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07984">
        <property type="entry name" value="NTP_transf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01153">
        <property type="entry name" value="DUF1693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX69340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="354" mass="40974" checksum="B8616A1C05A0DDC9" modified="2011-04-05" version="1" fragment="single">QQRFAVLSYEQVSRVHDVMNETVSIHGRGNFPTLELRLRDLVTLVRAKLEADGVAVKDMRINGGAASYVLALDRCQPQAYNDLDLIFGVDLSSARTYDRIKTAVLDSLLDFLPAGVSRTRMLSCSLKEAYVSKMVKVTEGDRWSLISLGTNHRGKNVELKFVHNMRRQFEFSVDSFQIILDSLVLFYDCASTMPISESFYPTVVAESVYGDFRQAHYHLHHKMIATRNPEEIRGGGLLKYCNLLVKDYRPADPDQIKTFERYMCSRFFIDFPDVGQQRLKLDNYLWNHFVGADEALKYDYLMILYSVVDESTVCLMGHERRQTLSLIEELAYQAYYADQHHQQQQQQQHHHHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGZ4</accession>
    <name>E9HGZ4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_114080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732644">
        <property type="protein sequence ID" value="EFX68970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68970">
        <property type="protein sequence ID" value="EFX68970"/>
        <property type="gene ID" value="DAPPUDRAFT_114080"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_114080"/>
    <dbReference type="HOGENOM" id="CLU_1733321_0_0_1"/>
    <dbReference type="OrthoDB" id="999269at2759"/>
    <dbReference type="PhylomeDB" id="E9HGZ4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="151" mass="17459" checksum="AF8F14BA9312F3F3" modified="2011-04-05" version="1">MLLDDNLVVRQWQDFRLTAAQELRQYFNLDEELQSRLDQAADDLQEQDNIENDNLNQLEWQQAVGMRPAGEQEVRSDLPVIDRSFPWLTSLLSEVQTLLLLRARWHHVEMRKCEVPGLTICAVGSSSPLSLSLPFSLFSLVARRFSQRSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJ80</accession>
    <name>E9HJ80_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_260450</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732660">
        <property type="protein sequence ID" value="EFX68216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68216"/>
    <dbReference type="EnsemblMetazoa" id="EFX68216">
        <property type="protein sequence ID" value="EFX68216"/>
        <property type="gene ID" value="DAPPUDRAFT_260450"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_260450"/>
    <dbReference type="eggNOG" id="KOG3649">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1442445_0_0_1"/>
    <dbReference type="OMA" id="HAANTAC"/>
    <dbReference type="OrthoDB" id="1396965at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904684">
        <property type="term" value="P:negative regulation of metalloendopeptidase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039016">
        <property type="entry name" value="RECK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13487">
        <property type="entry name" value="PTHR13487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="188" mass="20751" checksum="E3CF97169B4DF944" modified="2011-04-05" version="1">MILNRKNRDSGHGRGRPSLMDHTLLPPTDPQLQRDMVSHCPPSMQEVFWNCLNITIGPKHDGDYLGRQCCSLSPVHRCQTACLRAKQYSEDLANECRKSDNMQLFQCLNLIREGEECCSLSADSKCRKACSTVYSATATSASGAGINGTLRHAANTACSRSPNVLQCAKNLLKVDRLPISTSIDPKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJK2</accession>
    <name>E9HJK2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX68119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68119"/>
    <dbReference type="EnsemblMetazoa" id="EFX68119">
        <property type="protein sequence ID" value="EFX68119"/>
        <property type="gene ID" value="DAPPUDRAFT_37840"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_37840"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_7_6_1"/>
    <dbReference type="InParanoid" id="E9HJK2"/>
    <dbReference type="OrthoDB" id="754573at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
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        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="PTHR10218"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="57" mass="6629" checksum="96951B7214DEAAA8" modified="2011-04-05" version="1" fragment="single">KLFDSICNNKWFVETSIILFLNKKDLFEEKITKSSLTICFPEYPGSNTYEEGAAYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLL4</accession>
    <name>E9HLL4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
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                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Shapiro H."/>
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                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732679">
        <property type="protein sequence ID" value="EFX67374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67374">
        <property type="protein sequence ID" value="EFX67374"/>
        <property type="gene ID" value="DAPPUDRAFT_261751"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_261751"/>
    <dbReference type="eggNOG" id="ENOG502RR3F">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_044257_0_0_1"/>
    <dbReference type="InParanoid" id="E9HLL4"/>
    <dbReference type="OrthoDB" id="1884219at2759"/>
    <dbReference type="PhylomeDB" id="E9HLL4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="432" mass="50525" checksum="92C46386BFE3347B" modified="2011-04-05" version="1">MCYDDSIVYNVISDVDAVITSRNISSYSEVLAMHNHGQRLIVELMQYIEKEWEAENSVFAKLKADKECMREYFVMVSQGLENSKLFVATMERTLEKVAVSAFREEMVLKTFREIRNERWLYDARFMQKHMDLYLIDLLQKKEVDKVLDYIDQPKRLYQTVLQRLIAEKVPRSDEEWRCFVVHLKQAIEKAALATLEVDSGRAQDFVGQLRNEFLHGYLQSELLASVFLIDCRDEYQDCDKEEKKEFLSACTTKLIQVIKNQKFPPKKREFAKRFGPKVVQYMKALNDPAALPRCDACCTMCKSLCIEAANHDTKLTPHDAIHQPAGIAGVHCSKSRELISTTCSQSYEQDQTFQLPNEDENVIHKFRDYAKVFNGWKDPRINEELPLREYILAKYNDDIAQKYGFKPCPEIPPNYFRDLSTIKRQLEREIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLZ3</accession>
    <name>E9HLZ3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Diacylglycerol kinase</fullName>
            <shortName evidence="8">DAG kinase</shortName>
            <ecNumber evidence="8">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_203757</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="8"/>
    <dbReference type="EMBL" id="GL732683">
        <property type="protein sequence ID" value="EFX67242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67242"/>
    <dbReference type="EnsemblMetazoa" id="EFX67242">
        <property type="protein sequence ID" value="EFX67242"/>
        <property type="gene ID" value="DAPPUDRAFT_203757"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_203757"/>
    <dbReference type="eggNOG" id="KOG0782">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003770_4_0_1"/>
    <dbReference type="InParanoid" id="E9HLZ3"/>
    <dbReference type="OMA" id="CFLDSCT"/>
    <dbReference type="OrthoDB" id="274339at2759"/>
    <dbReference type="PhylomeDB" id="E9HLZ3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046339">
        <property type="term" value="P:diacylglycerol metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046834">
        <property type="term" value="P:lipid phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007205">
        <property type="term" value="P:protein kinase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PE/DAG-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="PTHR11255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="10">
        <location>
            <begin position="177"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="763"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="636"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="642"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX67242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="848" mass="94027" checksum="4DC784E237651245" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNZ5</accession>
    <name>E9HNZ5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_64608</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732701">
        <property type="protein sequence ID" value="EFX66536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66536"/>
    <dbReference type="EnsemblMetazoa" id="EFX66536">
        <property type="protein sequence ID" value="EFX66536"/>
        <property type="gene ID" value="DAPPUDRAFT_64608"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_64608"/>
    <dbReference type="eggNOG" id="KOG4222">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_003227_2_0_1"/>
    <dbReference type="InParanoid" id="E9HNZ5"/>
    <dbReference type="OMA" id="GYVCDLW"/>
    <dbReference type="OrthoDB" id="173520at2759"/>
    <dbReference type="PhylomeDB" id="E9HNZ5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
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        <source>
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    <sequence length="668" mass="72186" checksum="51AEA7BF90F70803" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="229" mass="26378" checksum="A195380F6E6946A2" modified="2011-04-05" version="1" fragment="single">MRDAWIRVETELTERLEAASRAAAPSRSIPTTTKRVKLPDLKIKQFDGDVFKWRSFWDIFKINFDQNADLSDVQKYSYLREYLTGKALRAVEGFEVTDDSYPKAVKTLKELFGNKDIAVQAHMSRLYNLQNTKQATDTASLERLYTEVNTHVRSLETLGENIKAFGGFIVTIMLHKLPDELILIWNREKKRSATDLEAMLTFIRDELAARDRCKQLKNSVGPAQQTTTR</sequence>
</entry>
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    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="PhylomeDB" id="E9HQE1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NFkB/Dor"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="4">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
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            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="309" mass="35105" checksum="4FDA6D5ECCC8244C" modified="2011-04-05" version="1" fragment="single">GDLRIVRIDKVCGCCTGQEEIFIFVEKVNKKDIKIRFFETDENEQEIWSAFADFSELNVHHQFAIAFKTPAYQYQNIQSDVTVQFQLYRPSNQSTSEAKSFTYTPRERVGKHGYFVFLAQSFNRKIPCRKYLITSNGDKIENTFSRIQRLFSSVGFPFFPNIRRNYSSSSFNTYGDNALHDALIHNQTDVVRAILHAASFHNTELDFVNAQNNANLTPLHISVFKNQIEATALLLQSGAIPGLVDANGNTPIHLAAIDKQLIDCLQLLLNTSICKPAHALKLNTRNYAGKHKLRIIDCGFSEVPYSNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9HQK8</accession>
    <name>E9HQK8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732722">
        <property type="protein sequence ID" value="EFX65972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX65972"/>
    <dbReference type="EnsemblMetazoa" id="EFX65972">
        <property type="protein sequence ID" value="EFX65972"/>
        <property type="gene ID" value="DAPPUDRAFT_16635"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_16635"/>
    <dbReference type="eggNOG" id="KOG0306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_817008_0_0_1"/>
    <dbReference type="InParanoid" id="E9HQK8"/>
    <dbReference type="OrthoDB" id="459903at2759"/>
    <dbReference type="PhylomeDB" id="E9HQK8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="274" mass="30339" checksum="03007781F74CF28F" modified="2011-04-05" version="1" fragment="single">ATKVGALSIPGHRTDVRALCFSLDKIALASASGESLKIWNRGSQNCIRTMACDYALSILFATGDHNVIVATKTGKLQIFDIAAGRLLEEIRAHEGEAWTVAMSPDLRGIASGGADKSVKFWQFEFVVDKAVEEEDEDGQMRGHGGQRMSLTHTKTLQLEEDVLCVRFSPDQRLIAVSLLDSTVKIFFADTLKFFLSLYGQHPGIVSKTHLFFSCGKDGKLKQWDADNFENITTLSGHHGQVWTLAVKKDGKYVSTAGHDRSIRLWERTQEPLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9HQX8</accession>
    <name>E9HQX8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_116906</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732727">
        <property type="protein sequence ID" value="EFX65863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65863">
        <property type="protein sequence ID" value="EFX65863"/>
        <property type="gene ID" value="DAPPUDRAFT_116906"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_116906"/>
    <dbReference type="eggNOG" id="ENOG502SUNW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_39_4_1"/>
    <dbReference type="InParanoid" id="E9HQX8"/>
    <dbReference type="OrthoDB" id="365628at2759"/>
    <dbReference type="PhylomeDB" id="E9HQX8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="150"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="394" mass="44567" checksum="869F960FE0DDE1B6" modified="2011-04-05" version="1">MCPPINRDLLLALKSVDLLVHEQEEATGGGGGGRAAVVRFEARCALYSVNPYQFSRPTTSKEKKIPPRVSVPRLVLLNARSVCKRKHDIADLIISSGLDFLAITETWLNVTHGDHILKSACPPGYMSLHVPRLVAKKKRGGDQFIYQNYRLYVIYRPPERPGFPTFSTFLSEFRTLLEFAVDNNEEPVIVGDFNIHVDDSNCNKARSFNQLVDELGWNQLVLGRTHSAAHTLDLILTRSGSKFVSDVQVAGLVSDHHLVICSVGLRRPVTERKSFSFRTYNSIDLDSLRADLSQLPLITAPAFVHQDQVATLDSLVDLFQEIRGVVESHAPLKTSVAVLRDPAPWINSDILVFRHKLRRAERIWRGGEYLQGHFESYKCLRSEYRRILFKDGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HTA7</accession>
    <name>E9HTA7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_265352</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732768">
        <property type="protein sequence ID" value="EFX65029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65029">
        <property type="protein sequence ID" value="EFX65029"/>
        <property type="gene ID" value="DAPPUDRAFT_265352"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_265352"/>
    <dbReference type="HOGENOM" id="CLU_1134551_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="245" mass="26425" checksum="C3E56CAEE0151113" modified="2011-04-05" version="1">MTENPKFRLLGTRGEAYRTEMVQGGWNKGPISQMSFLEQFFKESSIRGRAASADSEEGDFEDNRAPSVLSSSNKSALDLSSPVQSGPSHHLSPLRPEQQPSQTDGGNNGGSPFGQRSMDRSSGHIMQGSGMVDMSQNQYMLIADANAVAADDQLVSSVAAVQQQRRIDAAAALFAADEHIVAALQIAPVPGPLLLVAAQVQSLHVAHGRPQPAGRRMRSLRLYLTRSEASHKPNRSLANIRINKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9HTF4</accession>
    <name>E9HTF4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">La-related protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">La ribonucleoprotein domain family member 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DAPPUDRAFT_333645</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LARP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732772">
        <property type="protein sequence ID" value="EFX64977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX64977"/>
    <dbReference type="EnsemblMetazoa" id="EFX64977">
        <property type="protein sequence ID" value="EFX64977"/>
        <property type="gene ID" value="DAPPUDRAFT_333645"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_333645"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1367465_0_0_1"/>
    <dbReference type="InParanoid" id="E9HTF4"/>
    <dbReference type="OMA" id="HSASKAC"/>
    <dbReference type="OrthoDB" id="1499213at2759"/>
    <dbReference type="PhylomeDB" id="E9HTF4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097322">
        <property type="term" value="F:7SK snRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12290">
        <property type="entry name" value="RRM1_LARP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034887">
        <property type="entry name" value="LARP7_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="PTHR22792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="13">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="83"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFX64977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="200" mass="23032" checksum="A074A3947DA0C4C1" modified="2011-04-05" version="1">MEFYFSDANLSKDRFMQNVIKDGPEIPLHVFMNFNKLRALTEDLKEIAKALKFSKTLKLSEDDTKVSRITPFHPKSQEEVDLCTVYVERLPPHASIEWITSIFSEYGVVAYVSLPKFKDVTRIKGFAFVEFCDPESAAKAVTAYASSSEYHLLTEDPGQLCNIQAFNAESQQDEKGKRRKPAQNQKRRKMNPMLNQNRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9HTG8</accession>
    <name>E9HTG8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_304160</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="GL732773">
        <property type="protein sequence ID" value="EFX64963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX64963"/>
    <dbReference type="ESTHER" id="dappu-e9htg8">
        <property type="family name" value="Carb_B_Arthropoda"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64963">
        <property type="protein sequence ID" value="EFX64963"/>
        <property type="gene ID" value="DAPPUDRAFT_304160"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304160"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_13_2_1"/>
    <dbReference type="InParanoid" id="E9HTG8"/>
    <dbReference type="OMA" id="CHADEMI"/>
    <dbReference type="OrthoDB" id="754103at2759"/>
    <dbReference type="PhylomeDB" id="E9HTG8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005128581" description="Carboxylic ester hydrolase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="COesterase" evidence="3">
        <location>
            <begin position="47"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX64963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="598" mass="66141" checksum="40E6912B207B6C53" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9HU26</accession>
    <name>E9HU26_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_130522</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX64758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX64758"/>
        <property type="gene ID" value="DAPPUDRAFT_130522"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_130522"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_002678_2_1_1"/>
    <dbReference type="InParanoid" id="E9HU26"/>
    <dbReference type="OMA" id="CKEACAT"/>
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    <dbReference type="PhylomeDB" id="E9HU26"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="78"/>
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="134"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="170"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="201"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX64758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="364" mass="41892" checksum="22CDDBAFCCF862F0" modified="2011-04-05" version="1">MNKMKKKRGRPRSTKDPKAREFCCEHCGKTFKQLNVFRVHTRIHTGERPYQCELCGMSFNQIGTLKDHQKIHTGEKPHPCPHCPSRFTNKTRLTRHIRTHTGERPYKCDFCQMDFATQSVLVKHRRVHTGEKPFSCDECGMSFTQRSTLVNHKKVHTGKRRRYPQRLLYFLCKPCSRYYPTVEKLHSHVCLPTGQTPEGQHGCDSCPKKFSSSKAVKKHQAESHGPDADTEQVCVVCKEACATLDELVEHVQTHGKPKAPESAQQEPNVVTTFECSDCGKCCNTKAQLLIHQRIHTGERPFICPHCSKSFRYRQNLKEHLNSHQGSRPYACDQCDKRFAFSANLSTHKLTHGESKGRCRFCNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HWK0</accession>
    <name>E9HWK0_DAPPU</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_118744</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the borealin family.</text>
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        <property type="protein sequence ID" value="EFX63878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63878">
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        <property type="gene ID" value="DAPPUDRAFT_118744"/>
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        <property type="term" value="C:chromosome passenger complex"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX63878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="157" mass="17511" checksum="47FA9FE641A0079F" modified="2011-04-05" version="1">MGPCRIHGLKLLPIRGGADEIHGVVHDLPTTRHTPHAHDLPWPKKLPTLNQTIKQLKLITMLTTLHFQLIPIITPKFDPATGDIINERLQIPGETLYSEKGSPVVTSNPSKLSARELASLTTVGDKELVVAFLNNPETVNTFKAFEKTYNKHKSRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HWW9</accession>
    <name>E9HWW9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_335014</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732970">
        <property type="protein sequence ID" value="EFX63762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63762">
        <property type="protein sequence ID" value="EFX63762"/>
        <property type="gene ID" value="DAPPUDRAFT_335014"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_335014"/>
    <dbReference type="HOGENOM" id="CLU_1620702_0_0_1"/>
    <dbReference type="InParanoid" id="E9HWW9"/>
    <dbReference type="OrthoDB" id="1650971at2759"/>
    <dbReference type="PhylomeDB" id="E9HWW9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="164" mass="18354" checksum="6AE9E920A14C604B" modified="2011-04-05" version="1">MPKHGKSDVEWKSRLRDYAAGKFKFGQGQKPAKTSRWAKEICVIEKCPVKVCTTNLFGKIVTCTCGYHPSNSATSTTSILPDPEDHSAKDAGYPPRIQEEVDKAKVITETSVTTQSVKLPKHKFDFSHRLPDGWKSTLEVNDIQWITQSVFAGKGVLVSELKMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9HYR2</accession>
    <name>E9HYR2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_308319</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="term" value="P:adherens junction assembly"/>
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    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
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    </dbReference>
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        <property type="term" value="P:microtubule cytoskeleton organization"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="TBCD"/>
    </dbReference>
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        <property type="entry name" value="PTHR12658"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX62415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="368" mass="41518" checksum="DF02A0C77C76948C" modified="2011-04-05" version="1">MTTITTCRKKSKKYSAAKGIGRLTSRLSKNFADQVIESIMELFSLWESDMTWHGGCLALVELARHGLMLPQRLSSVLPFMEQAMLYDELGGNFFVGSAVRDAACYLCWALARSYDPSLLQPFVHQLDKALVITTVFDREEHVGRQGTFPHGIDILTTCDTFAYVKMPISNSVFSWRNKEYRPHLIQHLVDRKVIHWDTALHQMTFLDPESMKLILSTQILPRCTNPELYLRHGSILASGKVISALCQVAKDHQRLLPDELGDAAMEYITQTCIDILEERFWRSFGGDPMRIAVCHFIQDLSSGGFPLLDAVVDRWLKALRECLASADSNVQQSAISAVTALIGEYFRHQPVEKLTALSISTSTISYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9I1E4</accession>
    <name>E9I1E4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_120453</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733772">
        <property type="protein sequence ID" value="EFX62186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX62186"/>
        <property type="gene ID" value="DAPPUDRAFT_120453"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1564458_0_0_1"/>
    <dbReference type="InParanoid" id="E9I1E4"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX62186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="180" mass="20554" checksum="3865FEA5B3C62145" modified="2011-04-05" version="1">MDSLPQFDQFKVHCDPHTAGLRWEKWIIRFERLMEAINVVSQTADSADQKTATDKRRLALLLHYAGSEVEDVFDTLPAKELKLVKVSNSVSSSNDYYIRKTKVWTTVFGTWKNEELPGVDKELTNLENEDIIEPVTDGPTEWISPCHAVPKPKQPGKLRVCVDMRAPNKAILRKDTSFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9I1V7</accession>
    <name>E9I1V7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_271201</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733892">
        <property type="protein sequence ID" value="EFX62023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62023">
        <property type="protein sequence ID" value="EFX62023"/>
        <property type="gene ID" value="DAPPUDRAFT_271201"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_271201"/>
    <dbReference type="HOGENOM" id="CLU_144359_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9I1V7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX62023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="146" mass="16468" checksum="87B8CE1488B8E65C" modified="2011-04-05" version="1">MKSGSSLCFVVLVDSGIKQLLKQTQLFHILDDLAATPVFCYLVSSFDADNVAELDGFDELSLVDVFKELQAQVVQREYDFSQIRLLFKANENSLRNIFRDFGTTNLDLVPVENKLLSTLQNLSNQIQSDCPQNCLMKVQVSRAQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9I246</accession>
    <name>E9I246_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">XRN2-binding (XTBD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_271442</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733973">
        <property type="protein sequence ID" value="EFX61934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61934">
        <property type="protein sequence ID" value="EFX61934"/>
        <property type="gene ID" value="DAPPUDRAFT_271442"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_271442"/>
    <dbReference type="HOGENOM" id="CLU_2656964_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9I246"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021859">
        <property type="entry name" value="XTBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11952">
        <property type="entry name" value="XTBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51827">
        <property type="entry name" value="XTBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XRN2-binding (XTBD)" evidence="1">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX61934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="76" mass="9033" checksum="E7493E40BF46C4E8" modified="2011-04-05" version="1">MNRNRRQPPIGNSRKLFEPDDQWRLRKSFMERMKGKMLSNKSLLRLADKLVNVELLGLEYPMHVLKEKSQSQLVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9I279</accession>
    <name>E9I279_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_302699</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="gene ID" value="DAPPUDRAFT_302699"/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Zdobnov E.M."/>
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</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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    <feature type="non-terminal residue" evidence="3">
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX61391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="109" mass="12863" checksum="0C1C9817774BEC18" modified="2011-04-05" version="1" fragment="single">EKKWECETCEKVFRSMLYLNAHKKTVHTGKKWECDLCEKSFNTKSYLGAHKKTVHTGKKMQCDLCEKSYKTMKILDVHKRNVHTGKKWECDLCEKSFNTKSYLGAHKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9I3T0</accession>
    <name>E9I3T0_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_273989</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734727">
        <property type="protein sequence ID" value="EFX61350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX61350"/>
    <dbReference type="EnsemblMetazoa" id="EFX61350">
        <property type="protein sequence ID" value="EFX61350"/>
        <property type="gene ID" value="DAPPUDRAFT_273989"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_273989"/>
    <dbReference type="eggNOG" id="KOG1346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1275032_0_0_1"/>
    <dbReference type="OrthoDB" id="830428at2759"/>
    <dbReference type="PhylomeDB" id="E9I3T0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
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    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="217" mass="24620" checksum="9F3D3DA2EC8EA7D5" modified="2011-04-05" version="1" fragment="single">MLPQPTTPRLQLITPLKLSNTTLERPSRIEVSQVSFSDTQHGSPEVSNNLRFKQWNDKDKVNGGVAFVRVHRVVKLDIVGRKAELDDGRAISLRQVPYCHSGLSGALKDVHEHVMLFRNIDGDNIGRVLPKYLSQWTSEKVKAQGVNVLPKANVEGAILEDYKVALTLNDGQKYYTEAPKYYTTKSPEYYILYTEAPKYYSVPSYYTEAPTYYTTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9I5D1</accession>
    <name>E9I5D1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_70566</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX60799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG3714">
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    <dbReference type="HOGENOM" id="CLU_103588_2_1_1"/>
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    <dbReference type="PhylomeDB" id="E9I5D1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sperma_CUB_dom_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="107" mass="11752" checksum="91F6BAEED9FA453B" modified="2011-04-05" version="1" fragment="single">NLVGMIGTIKSPNYPAAYPDSSDFLWKIVTEPGTSIRLLFALFETQEKFDYVFVYDGPTVNSPLLLEKSGLSSTPFAVNSSSNEMLARFTSDENITLPGFLAVYSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
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    <name>E9I5S8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="2">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL735855">
        <property type="protein sequence ID" value="EFX60652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60652">
        <property type="protein sequence ID" value="EFX60652"/>
        <property type="gene ID" value="DAPPUDRAFT_123425"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_123425"/>
    <dbReference type="HOGENOM" id="CLU_077231_0_0_1"/>
    <dbReference type="InParanoid" id="E9I5S8"/>
    <dbReference type="OrthoDB" id="1282076at2759"/>
    <dbReference type="PhylomeDB" id="E9I5S8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="357" mass="40139" checksum="01CE8401AF09A927" modified="2011-04-05" version="1">MGNGKSGLCETIKKLSILQTAVTQQGIQVALTHLQSLNILENFNTLEALVKLSLSTIDSKPPGLYNNKFSISTLFTSPDKPFTSPDKPYISNGLHLALSLCHSVTVVLIHVTKGLKDSDLLCLMSLKVLRKLKIFKSNLWVPNDTEITFDGGVAPLLKVFGRSLETLALECFDLIRISTIMDFCPNLYALYMSDVTGSLENERHLFQSEKKPPVFKELKQLICILDVPVDILLFLLSSPSLERIAISCCDVLTDEILLETVKCQHRLNNLKKFELDKCDSVTKRGIDALLRSGCIPLEVIEIYRCKNIVDKNYADWNSLIVRKNWNYIPSMEKAIAFFSQPWITSNFRPFLFSGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9I5W4</accession>
    <name>E9I5W4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_123560</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL735942">
        <property type="protein sequence ID" value="EFX60616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60616">
        <property type="protein sequence ID" value="EFX60616"/>
        <property type="gene ID" value="DAPPUDRAFT_123560"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_123560"/>
    <dbReference type="HOGENOM" id="CLU_834880_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="333" mass="36613" checksum="4E0E308F0354C183" modified="2011-04-05" version="1" fragment="single">LNSGKSSIKDDVELRAPECPAGTDYVPLSLAEPPDPNVEFTPKEAIKDSRTFLWPTGSETALQLRVDTCIDNNDNFRVLRIVSRQDTSGVKQTVYEEFKADSGIKAEGILEALNGDVSKLLIFVPKSSPGGASFKITGTVVGGDQLTYIFKAWESDPEKAEARVFTFGTLISANPWAGEGEGDGEGPCSEDKTLQQYRYLVKTSNGEIDFTVVGCEFESFGTRRLEWRKAWLKDSGAPAGFANKVFTFTPDANSETSRFDYRFTHHNACEWHSFILPHASYGMTGAHRPGNIGGDSTECEQKGFAPRTKLEENVGFAFAYGGQPTFIERSILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9I7G2</accession>
    <name>E9I7G2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_345547</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL737205">
        <property type="protein sequence ID" value="EFX60069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60069">
        <property type="protein sequence ID" value="EFX60069"/>
        <property type="gene ID" value="DAPPUDRAFT_345547"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_345547"/>
    <dbReference type="HOGENOM" id="CLU_3074640_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="53" mass="5963" checksum="FF9271CC222A304A" modified="2011-04-05" version="1" fragment="single">MAIRGIISGSCYISDVIVVDITTRKIVLKFSTHLPEFGNAKYFSTCSYFVLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9I7M7</accession>
    <name>E9I7M7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_125896</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL737346">
        <property type="protein sequence ID" value="EFX60003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60003">
        <property type="protein sequence ID" value="EFX60003"/>
        <property type="gene ID" value="DAPPUDRAFT_125896"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_125896"/>
    <dbReference type="HOGENOM" id="CLU_947506_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX60003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="294" mass="31580" checksum="09B8271A5336C200" modified="2011-04-05" version="1">MMFSARLESLSVKRGLWSNVLRSLRWGEPDSVMQLYGWLSAGGRYNVVPPLDADQIRFWSNCADGSKFSVPRAARYLATYLVAAIVAALLVFFVNMEAPKHGGPSFFANFLEKWADVASLCAGLARVATKPVGMGSHLVCAEFCFDGVAGVRGSANAVVRCCDLGVGLLVDEGKVCQSLGHWIHTSMAVVVDIFGGATSEGVCTPDGYSGCSRTHCRLIFAGAVGLRAIPVAPIGGVSLMEPLLNAPRCRVVERGVKIVGCKANRECRRHSPSADFFCSPSPGLSLRSCWRFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSQ6</accession>
    <name>E9FSQ6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="2">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_187016</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="2"/>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89781"/>
    <dbReference type="EnsemblMetazoa" id="EFX89781">
        <property type="protein sequence ID" value="EFX89781"/>
        <property type="gene ID" value="DAPPUDRAFT_187016"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_187016"/>
    <dbReference type="eggNOG" id="KOG3093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_2_1_1"/>
    <dbReference type="InParanoid" id="E9FSQ6"/>
    <dbReference type="OMA" id="MPLVGFD"/>
    <dbReference type="OrthoDB" id="1425233at2759"/>
    <dbReference type="PhylomeDB" id="E9FSQ6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="142"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX89781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="199" mass="22700" checksum="564633A87014826D" modified="2011-04-05" version="1">MERFAAKAALRTRIKIALKQLQCSERTRQSIEVTKKVLAHPKYASSRGIAVFLSMNDEIDTSNIVRDIFDSGKHCFIPRYQESDGHMTMIRMHTYEELESLPRTKWNIPQPSKIDQREDCLQTGGLDLILTPGLAFTNSGHRLGRGKGFYDKFLITYSSVYKPPYLIGLALTPSIVDSIPCTLNDFKMDEILYDNLVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9FTK9</accession>
    <name>E9FTK9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_233234</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89620">
        <property type="protein sequence ID" value="EFX89620"/>
        <property type="gene ID" value="DAPPUDRAFT_233234"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_233234"/>
    <dbReference type="HOGENOM" id="CLU_2280193_0_0_1"/>
    <dbReference type="InParanoid" id="E9FTK9"/>
    <dbReference type="OrthoDB" id="1636503at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003239760" evidence="1">
        <location>
            <begin position="37"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="102" mass="10776" checksum="1F7D0E7809AE0203" modified="2011-04-05" version="1">MPATRGNHHTAATMAVAAVLTFVVLVVVGAPSFAEAGSIPPPHCNPDVSDALPPRLRRICAALYGIAEISNAVEQYLDDKSNASRLFLYASAHSAHVHRSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9FU38</accession>
    <name>E9FU38_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IRS-type PTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_17604</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89477"/>
    <dbReference type="EnsemblMetazoa" id="EFX89477">
        <property type="protein sequence ID" value="EFX89477"/>
        <property type="gene ID" value="DAPPUDRAFT_17604"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_17604"/>
    <dbReference type="eggNOG" id="KOG4047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180480_0_0_1"/>
    <dbReference type="InParanoid" id="E9FU38"/>
    <dbReference type="OMA" id="YAFRCGR"/>
    <dbReference type="OrthoDB" id="473504at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005104">
        <property type="term" value="F:fibroblast growth factor receptor binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005068">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008543">
        <property type="term" value="P:fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:transmembrane receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01202">
        <property type="entry name" value="PTB_FRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038742">
        <property type="entry name" value="FRS2_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX89477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="81" mass="9358" checksum="A2A6356FCC024A2C" modified="2011-04-05" version="1" fragment="single">QVMNVDDTGRRLCPGQLEVGESDLILYQRGKTPVRWPLRSLRRYGFDAQLFSFECGRRCPTGPGIYAFHCRNAEILFNHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E9FV84</accession>
    <name>E9FV84_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_41292</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX89153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89153"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_41292"/>
    <dbReference type="eggNOG" id="KOG4566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079452_4_2_1"/>
    <dbReference type="InParanoid" id="E9FV84"/>
    <dbReference type="OMA" id="RDSENDY"/>
    <dbReference type="OrthoDB" id="460176at2759"/>
    <dbReference type="PhylomeDB" id="E9FV84"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040008">
        <property type="term" value="P:regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10387">
        <property type="entry name" value="SH2_SOCS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035865">
        <property type="entry name" value="SOCS6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SSF158235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SSF55550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="15"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="6">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX89153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="166" mass="19310" checksum="CBEDB53551379B6F" modified="2011-04-05" version="1" fragment="single">SNLAWELFKLVKYGWYWGRMTRGEAERKLVDQPDGAFLVRDSSDDCHLLSLSFRSYGRTLHTRIEHTNGYFSFYAYPEAEQHSSVGQLIEHLMDTSRSGIFCYSRSRSPGSPSYPVRLTKPVSRFSEVLPLQYMCRFVIRQYVRMDHIEALPLPESLKSFIVRGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E9FWA6</accession>
    <name>E9FWA6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_221078</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX87858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87858"/>
    <dbReference type="EnsemblMetazoa" id="EFX87858">
        <property type="protein sequence ID" value="EFX87858"/>
        <property type="gene ID" value="DAPPUDRAFT_221078"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_221078"/>
    <dbReference type="eggNOG" id="KOG3611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009051_7_0_1"/>
    <dbReference type="InParanoid" id="E9FWA6"/>
    <dbReference type="OrthoDB" id="493443at2759"/>
    <dbReference type="PhylomeDB" id="E9FWA6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050919">
        <property type="term" value="P:negative chemotaxis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048843">
        <property type="term" value="P:negative regulation of axon extension involved in axon guidance"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11237">
        <property type="entry name" value="Sema_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042068">
        <property type="entry name" value="SEM1A_sema_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="PTHR11036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="SSF101912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="7">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="483"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="788"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="788"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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        </source>
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    <sequence length="892" mass="96615" checksum="EF90D1B24FCF8DEC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9FWT2</accession>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Daphnia</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="18"/>
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    <sequence length="338" mass="37538" checksum="511F77E82D2AF968" modified="2011-04-05" version="1">MATTAVVVTNCILRRTTCFAIMVNYFVVLLLGVVSLMAESTTGVLKSPGDGGYQSTTPPSYYATTTYDTTSYYTEAPKYYTTKEPEYYTTTNAAPAYYTEALKYYSAPSYYTEVPAYYTTKTVEYYTEVIMVIIAYECSNYYICLVNNGLLLLGAESLMAGLNTGVPMSPGYGGYQTTTPPSDCTTTYATTSYYTEASKYYTTNVPDSDPSLYYTEAPKYYSSPSSTTKSSEYYTTTYAAPAQNNTPRLPSTTLLSATAPRLQLITPPTVEIHTEVPKYYSAPSYTTLTEAVNYYVASTFYTTAAPSCYAEPKYYTEAPVYYTTTYATLCHYYTEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
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            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
    <sequence length="839" mass="91402" checksum="26129C3D6DB57DBA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9FY96</accession>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87814">
        <property type="protein sequence ID" value="EFX87814"/>
        <property type="gene ID" value="DAPPUDRAFT_306369"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306369"/>
    <dbReference type="eggNOG" id="KOG4824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068449_2_0_1"/>
    <dbReference type="InParanoid" id="E9FY96"/>
    <dbReference type="OMA" id="RNGECVT"/>
    <dbReference type="OrthoDB" id="1631943at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031409">
        <property type="term" value="F:pigment binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003057">
        <property type="entry name" value="Invtbrt_color"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01273">
        <property type="entry name" value="INVTBRTCOLOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013434846" description="Lipocln_cytosolic_FA-bd_dom domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocln_cytosolic_FA-bd_dom" evidence="3">
        <location>
            <begin position="42"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX87814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="192" mass="21136" checksum="4AEDC2223AB050DA" modified="2011-04-05" version="1">MLSYSKLWLCLLITLGCSYRTAVDAQVYSLGSCPGVNVVSNFDVDKYTGKWYENRSYFAIFQIGLDCITAEYTKSDTGVTVKNEGTKKILRTKSIVTGTARQLEAPNGKLGVTFASIPFAPADAPYWVLGTDYTSYAVVWSCTNRAFFNSQIAWILTREQFPSTDTINTALAVLATNGISQNPLKTTTQNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9FY99</accession>
    <name>E9FY99_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_221453</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87812">
        <property type="protein sequence ID" value="EFX87812"/>
        <property type="gene ID" value="DAPPUDRAFT_221453"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_221453"/>
    <dbReference type="HOGENOM" id="CLU_1039227_0_0_1"/>
    <dbReference type="OrthoDB" id="1114912at2759"/>
    <dbReference type="PhylomeDB" id="E9FY99"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX87812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="268" mass="30712" checksum="167D5D2312B6E795" modified="2011-04-05" version="1">MADNLCGSEAKHSNHNVENVIRGEIVNVIRITGKKKNSRLLKTGDMYLFYTTDHTKRLRESVYRCRRYSYRSLPCPARLIYRDGVYRNSLESHNHRNEVVEISQIEFTNECCRRVRERRAPGGLKGIFEQVRNERPEVNVEFEGALERRMQRIKKGNNPRPVDRAIQIPPAEVQVQPTNEVREEVAPLDRAAVGGPRGNPNPAENEEHPQAPAPLRCPICLFNQVVWSCGPSSVVTIVSFLNMQVDLRQQLVSQKENVISGNRYRIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZ61</accession>
    <name>E9FZ61_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TBC1D23_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_96933</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87656"/>
    <dbReference type="EnsemblMetazoa" id="EFX87656">
        <property type="protein sequence ID" value="EFX87656"/>
        <property type="gene ID" value="DAPPUDRAFT_96933"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_96933"/>
    <dbReference type="eggNOG" id="KOG3636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_763458_0_0_1"/>
    <dbReference type="InParanoid" id="E9FZ61"/>
    <dbReference type="OMA" id="HITGAMH"/>
    <dbReference type="OrthoDB" id="429640at2759"/>
    <dbReference type="PhylomeDB" id="E9FZ61"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099041">
        <property type="term" value="P:vesicle tethering to Golgi"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039755">
        <property type="entry name" value="TBC1D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045799">
        <property type="entry name" value="TBC1D23_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297">
        <property type="entry name" value="PTHR13297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19430">
        <property type="entry name" value="TBC1D23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TBC1D23_C" evidence="2">
        <location>
            <begin position="204"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX87656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="363" mass="39292" checksum="0ED10DAABDA8D9B6" modified="2011-04-05" version="1">MLTEPQAFSVAVQALLSSQKQSIAAQSAAGGEHLVFFGSGREAEDQYVHMVVAFFLQRHVQFVGLVQGGFSAVHQALVAAQIENGVVATSVSIEPVGLIDHNPSLCLVCTVNKSEESPIAAGKSNAQGTPQHATGSSSSSYNKTDFFGRMRSKSAVVKDKLLDYIVNPISAGDNEPTPKSKSKGAEFHLCASKFTSLSNSFILEHPSTGGKSKGAGKLYRNIAPVFSIDDDQDGDDPTFEGSSEREADAPNQELVAISSWLKRPDVINSFRCHEVKESGHAFPRNYGCCMGEPHSRLKKIGKHFVKKCLKCFVKKCFKKLCKHFVCCIEQSRQHPNPSASCYTASKLVYTRPGGIPPLPNHCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9G181</accession>
    <name>E9G181_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_25304</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85725">
        <property type="protein sequence ID" value="EFX85725"/>
        <property type="gene ID" value="DAPPUDRAFT_237164"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_237164"/>
    <dbReference type="HOGENOM" id="CLU_2851966_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9G373"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX85725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="65" mass="7634" checksum="7260CD6E2A64A301" modified="2011-04-05" version="1">MCRDKVIEHAVSLWNRVVLARRFLSQRWVLSMTNVLLHPYLPDVSSSSSCFIASYRKYKVLVLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9G4Z9</accession>
    <name>E9G4Z9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA_pol_L_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_230556</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX85388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85388"/>
    <dbReference type="EnsemblMetazoa" id="EFX85388">
        <property type="protein sequence ID" value="EFX85388"/>
        <property type="gene ID" value="DAPPUDRAFT_230556"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230556"/>
    <dbReference type="eggNOG" id="KOG4392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090381_2_2_1"/>
    <dbReference type="InParanoid" id="E9G4Z9"/>
    <dbReference type="OMA" id="LEQACTK"/>
    <dbReference type="OrthoDB" id="1398114at2759"/>
    <dbReference type="PhylomeDB" id="E9G4Z9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001055">
        <property type="term" value="F:RNA polymerase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA_pol_L_2" evidence="8">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX85388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="117" mass="13406" checksum="FDC0C6BB54A7168B" modified="2011-04-05" version="1">MNAPPSFESFLLFEGEKKIIVEQDTKVPNAAIFTVNKEDHTLGNMIRCQLLKDPNVLFAGYKQPHPLEHKFILRIQSTPAYSPHDALMNAITDLISELSLLEERFRDAVREKREGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9G5J7</accession>
    <name>E9G5J7_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85619">
        <property type="protein sequence ID" value="EFX85619"/>
        <property type="gene ID" value="DAPPUDRAFT_300367"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300367"/>
    <dbReference type="eggNOG" id="ENOG502TB95">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1210855_0_0_1"/>
    <dbReference type="InParanoid" id="E9G5J7"/>
    <dbReference type="OMA" id="KDDYSKD"/>
    <dbReference type="OrthoDB" id="1859928at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040384">
        <property type="entry name" value="FCAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33864">
        <property type="entry name" value="PTHR33864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237186" evidence="2">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX85619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="229" mass="26315" checksum="B7E3F5AA1E6ACB53" modified="2011-04-05" version="1">MVKFTIALVALMIASAVATTASDQYSYKRGGYSYDDSSISDTAHKAPTYGYDKKSNNSHQPSTEYNKKPSYGYQSASWKPIYGYQAAPYGYDKKPSYEYQPSSYGYSKKPSYEYSPPSYGYDKKPGYEYQQTPYGYGKAASYEYSPPSYGYDKKPSYEYQPSYGYHQKSRYEYSRPSTYGYEAKPSYEYQQPYGYNKKPTSYEHSPSSYGYEKYEKPKSYGTVYSAASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9G5R1</accession>
    <name>E9G5R1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_28601</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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    </evidence>
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        <source>
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        </source>
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</entry>
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    <accession>E9G859</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX83920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83920">
        <property type="protein sequence ID" value="EFX83920"/>
        <property type="gene ID" value="DAPPUDRAFT_239036"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_239036"/>
    <dbReference type="HOGENOM" id="CLU_3034460_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="55" mass="6031" checksum="19A31B482F8F59D5" modified="2011-04-05" version="1">MAFVRSVKVTNGPRKTLGETASAPKDGPRDANENQERLGGTEFPSSQFPAHYEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8J2</accession>
    <name>E9G8J2_DAPPU</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">DAPPUDRAFT_47305</name>
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    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX83983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83983"/>
    <dbReference type="EnsemblMetazoa" id="EFX83983">
        <property type="protein sequence ID" value="EFX83983"/>
        <property type="gene ID" value="DAPPUDRAFT_47305"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_47305"/>
    <dbReference type="eggNOG" id="ENOG502QU0D">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_421879_0_0_1"/>
    <dbReference type="InParanoid" id="E9G8J2"/>
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    <dbReference type="OrthoDB" id="1040332at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ELYS-bb"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="ELYS" evidence="2">
        <location>
            <begin position="338"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX83983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="650" mass="74637" checksum="D01E82CA2F358394" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8K2</accession>
    <name>E9G8K2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GLOBIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_223071</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX83989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83989">
        <property type="protein sequence ID" value="EFX83989"/>
        <property type="gene ID" value="DAPPUDRAFT_223071"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_223071"/>
    <dbReference type="HOGENOM" id="CLU_114678_0_0_1"/>
    <dbReference type="InParanoid" id="E9G8K2"/>
    <dbReference type="OrthoDB" id="1379813at2759"/>
    <dbReference type="PhylomeDB" id="E9G8K2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240968" description="GLOBIN domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="GLOBIN" evidence="7">
        <location>
            <begin position="95"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX83989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="226" mass="25380" checksum="AB9EDC9A9AC2F657" modified="2011-04-05" version="1">MSWLILVFCSILSLSAGQSPFNEGIPGGVESGGYGDSTMRGSGPFVTTTTVTTILDFNPAGMSRSMRSYPSASERSYHYGDKKFGSFSQKDVDVIVNTWNTLKRRGDFAPKVFIRYFKAKPESQKMFPAFANVPITELPTNHDFLNSAYTCITSLNYLIPYLKFDHPERCPAFPKHLKDKYNAVDLKKLGSIWMTAMQEEMGNAFTNDVRDVWKKAVMAVIEYASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9J7</accession>
    <name>E9G9J7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_315371</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83868"/>
    <dbReference type="EnsemblMetazoa" id="EFX83868">
        <property type="protein sequence ID" value="EFX83868"/>
        <property type="gene ID" value="DAPPUDRAFT_315371"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315371"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_22_2_1"/>
    <dbReference type="InParanoid" id="E9G9J7"/>
    <dbReference type="OMA" id="LEHESDI"/>
    <dbReference type="OrthoDB" id="702827at2759"/>
    <dbReference type="PhylomeDB" id="E9G9J7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX83868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="116" mass="13321" checksum="366DB3EDBB193C0D" modified="2011-04-05" version="1">MQLEMDQVCGDSLPSLHHKPQLVYTQAVLMEVQRMSGVSPLAIPRRALKSIPFEGYIIPQDAYVIINMYSVHMDETYWTDPEVFRPERHIDKFGHIIKTDRLFPFGAGKRSCLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9Z9</accession>
    <name>E9G9Z9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_315524</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83795">
        <property type="protein sequence ID" value="EFX83795"/>
        <property type="gene ID" value="DAPPUDRAFT_315524"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315524"/>
    <dbReference type="eggNOG" id="ENOG502SCY1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1043012_0_0_1"/>
    <dbReference type="OrthoDB" id="199124at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="267" mass="29446" checksum="1740255FC36A9559" modified="2011-04-05" version="1">MTEYQPFQRLSARSVSLRQPNRVQASPMNSPTLLGSSVPRPYVPGRIGLAEQKSLILQQRATIRDQFFQTPLTAPPLISSMMSNSNIKSKLSLPRTDELSGSSSFTEKPSPAQSTVSSSASKKYYETDLDLTIKVPKKSGESFHQETRKNLASSETGGPTTASRVINISVVKSESLNYVSQNNETNTGHLTNKENTEDIKMDRPNFTKKSSEDNFRTFPSLTELNINFKSITGQKILQGLNSNSTDTLVELSMRDGPDVGKSDLSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAB6</accession>
    <name>E9GAB6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Decapping nuclease</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_47834</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83717"/>
    <dbReference type="EnsemblMetazoa" id="EFX83717">
        <property type="protein sequence ID" value="EFX83717"/>
        <property type="gene ID" value="DAPPUDRAFT_47834"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_47834"/>
    <dbReference type="eggNOG" id="KOG1982">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024877_1_1_1"/>
    <dbReference type="InParanoid" id="E9GAB6"/>
    <dbReference type="OMA" id="MAYWGYK"/>
    <dbReference type="OrthoDB" id="1034620at2759"/>
    <dbReference type="PhylomeDB" id="E9GAB6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:RNA pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090305">
        <property type="term" value="P:nucleic acid phosphodiester bond hydrolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="PTHR12395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1" evidence="3">
        <location>
            <begin position="207"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX83717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="360" mass="41830" checksum="EF26D311FD46DD23" modified="2011-04-05" version="1" fragment="single">GNFPEFTRPKNVGSFSLDIHRNYVNDYSELRYLSMPPEASTSGSCKVNFDLKRGVSRVVEKDEESIRQKMLDDLLRWILQERKAEHKNIIDHQHPLRPLLVEFVCYRGLLTLLIETPYECQENWTILATRFQNSIYLWQLKESKKQNGSIAVQKEKSIWGFKFEQYLCASSPNGNPNPNEQVNTNAEFCCVLKTRIGGLPLLYGAEVDAVTKESQPPFLDLQNFVELKTNKHIGNEMQQAAFNRFKSMKWWAQSFIVGIPKIVVGYRDDDGIVSRLETMDVNQLRKQSTDCWKSNICMNFCLKFLKFVKECIPKDSTSNDHFLFEFDAMSRVISFRNELGETRSRNLLPSWYVESMQKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9GB16</accession>
    <name>E9GB16_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti_prolifrtn domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_48149</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83357"/>
    <dbReference type="EnsemblMetazoa" id="EFX83357">
        <property type="protein sequence ID" value="EFX83357"/>
        <property type="gene ID" value="DAPPUDRAFT_48149"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_48149"/>
    <dbReference type="eggNOG" id="KOG4006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079660_4_2_1"/>
    <dbReference type="InParanoid" id="E9GB16"/>
    <dbReference type="OMA" id="RYPGEWR"/>
    <dbReference type="OrthoDB" id="1455216at2759"/>
    <dbReference type="PhylomeDB" id="E9GB16"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045930">
        <property type="term" value="P:negative regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="PTHR22978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="SSF160696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti_prolifrtn" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX83357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="116" mass="13691" checksum="CE4142B61ABE625A" modified="2011-04-05" version="1">MKEEIEAAALFITQLVSQSSQLANLPEDRLQTFKRHLIRLFEERFHNHWFPDRPQRGQGFRCIRLNGGSRPDPLIQKAALETGLEYCDLRLPVEFTMWVDPREVSCRWEIHVQITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9GC92</accession>
    <name>E9GC92_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_101078</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732539">
        <property type="protein sequence ID" value="EFX82902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82902">
        <property type="protein sequence ID" value="EFX82902"/>
        <property type="gene ID" value="DAPPUDRAFT_101078"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_101078"/>
    <dbReference type="HOGENOM" id="CLU_007156_0_0_1"/>
    <dbReference type="InParanoid" id="E9GC92"/>
    <dbReference type="OrthoDB" id="1504996at2759"/>
    <dbReference type="PhylomeDB" id="E9GC92"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="PTHR10237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="982"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX82902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1024" mass="117628" checksum="DCC7A587DFAE9BCB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9GCT6</accession>
    <name>E9GCT6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_101239</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732539">
        <property type="protein sequence ID" value="EFX82808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82808">
        <property type="protein sequence ID" value="EFX82808"/>
        <property type="gene ID" value="DAPPUDRAFT_101239"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_101239"/>
    <dbReference type="HOGENOM" id="CLU_588310_0_0_1"/>
    <dbReference type="OrthoDB" id="1551569at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX82808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="465" mass="51611" checksum="5A5ED2FD54C6F8C9" modified="2011-04-05" version="1">MKIMCCYCGVYYAKGIFTIPSNNPAIEEEWKKQIPGCEELLKVNKNLPLCYNHFAETDVIKEDIYVINSKSVSVPRMKWSLAPNSVPSIFNDNSLSFGVSRLLKGGLQLQDASLSTKDCGTATASFEMDSSTMAINNNNSEVPVQQLLPYSTLQNQHNVKQSSIEINPPILYQPHEMNKGHKTTSEADISMDSSSTVIKRSLEQKTTTSGNTHLGCCDVEGISASSVGQFNHENLNVVVGGTTPTPVDGPIVGVFVMIPNSIKLPGENWYSMRGAEQILFCCEAIVKEEVVVIRKGVKIDVKAKSISFFVHQDALPLDKELPCGLYRNFDTVNSLNETLKIFDALPLCAGIDDVPCHFVKDCSTDFGIFKNGFWHSTACAVFPDSREVQGLCGSCFSFKQTLLLRYFQQGGNPSTPLANNKKYVVNKYLSNEELVKSKQETQKEIRILKQKLRRTESRLMVGLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GE60</accession>
    <name>E9GE60_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_241392</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82208">
        <property type="protein sequence ID" value="EFX82208"/>
        <property type="gene ID" value="DAPPUDRAFT_241392"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241392"/>
    <dbReference type="HOGENOM" id="CLU_1251777_0_0_1"/>
    <dbReference type="OrthoDB" id="1838065at2759"/>
    <dbReference type="PhylomeDB" id="E9GE60"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241142" evidence="1">
        <location>
            <begin position="17"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX82208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="221" mass="22958" checksum="DD80B402C83789BC" modified="2011-04-05" version="1">MQKYLIALMLMTVASATLDAGNKDADAVKSDSSTPVESVANYRTDQRIRRQAATPITPNVVPVIDGANIPSTFLTRVQAPEVKTLASQLADNSVDSKPEDESTKQLGGLLGGILGGLLPNSPQCVYNNNCAFIGLQLYVVLNILDPVVCGNEVCAGDAQCTHFTHNPVTGECTLHKAPGTGGGWATTTPTLVGSVCGHIPKRSCGAGSLLSLCLGLNLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEL3</accession>
    <name>E9GEL3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="3">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_316998</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Golgi apparatus membrane</location>
            <topology evidence="1 3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="3"/>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82285">
        <property type="protein sequence ID" value="EFX82285"/>
        <property type="gene ID" value="DAPPUDRAFT_316998"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_316998"/>
    <dbReference type="eggNOG" id="KOG4651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2443059_0_0_1"/>
    <dbReference type="OrthoDB" id="1330889at2759"/>
    <dbReference type="PhylomeDB" id="E9GEL3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="PTHR12137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX82285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="90" mass="10487" checksum="0F3E13FDAA034D8F" modified="2011-04-05" version="1">MTDDLSAIPSLTVHEQNPMRKLYASNLNDTVNNRVGDLTKFIFVRHPFERLVSAYRDKLTRNNPIYHKMVGKVIIRKVRKNASRLSPYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9GGC3</accession>
    <name>E9GGC3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_33294</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732543">
        <property type="protein sequence ID" value="EFX81376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81376"/>
    <dbReference type="EnsemblMetazoa" id="EFX81376">
        <property type="protein sequence ID" value="EFX81376"/>
        <property type="gene ID" value="DAPPUDRAFT_33294"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_33294"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_7_40_1"/>
    <dbReference type="InParanoid" id="E9GGC3"/>
    <dbReference type="OrthoDB" id="530072at2759"/>
    <dbReference type="PhylomeDB" id="E9GGC3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="232" mass="26746" checksum="F27DFC4AF4DE7A3D" modified="2011-04-05" version="1" fragment="single">TRVLLRILSTRDEDLNIEFRRQVDMFHRVRHANLVAVLGCCRDSPDFQMILMEYHPYINLKSHLLSTISSSQPPWSVAKIQSATIQIARGMNALAEARFVHRGVILAREISWSHSMAQIIPSFGMDKEPFNNDYNIYKHQSIALRWLPHEAALEDEYSTKSDVWMFAVTIWELHHAAQLPLSDRSDEVLLADLRKKCGQLWDASFCKSNATSSLLVKCWSHDPILRPSFDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9GHH6</accession>
    <name>E9GHH6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_317976</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732545">
        <property type="protein sequence ID" value="EFX81061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81061">
        <property type="protein sequence ID" value="EFX81061"/>
        <property type="gene ID" value="DAPPUDRAFT_317976"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_317976"/>
    <dbReference type="HOGENOM" id="CLU_270431_0_0_1"/>
    <dbReference type="OrthoDB" id="1800811at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241211" evidence="3">
        <location>
            <begin position="24"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1046"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX81061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1204" mass="132119" checksum="1A8463D749EA284E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GHN5</accession>
    <name>E9GHN5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_242922</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732545">
        <property type="protein sequence ID" value="EFX81023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81023">
        <property type="protein sequence ID" value="EFX81023"/>
        <property type="gene ID" value="DAPPUDRAFT_242922"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_242922"/>
    <dbReference type="HOGENOM" id="CLU_1278779_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GHN5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="216" mass="23752" checksum="CCAF66820DB77259" modified="2011-04-05" version="1">MLQDQNYCVAPYPLPTDIIFKFCMSSLDSGCWLLASAQLSSLLFYQTRKPPDLETPRGSKLQCDETMSRENRRVAAISWSSTDSAVGIGGSDGKSVPSASSEQSLSGPTTYLVAPNSEVLAQLIRDNETRADAGHYTSPASAFNRFTEPNEPSCEHMEQERRMLDRERRLSVAASSSDRSDTDSMDGANAYKKDRSTPLQGNQLDDQSVVVKNLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIH9</accession>
    <name>E9GIH9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_318334</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX80392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="120" mass="13051" checksum="45594D806C6A774E" modified="2011-04-05" version="1">MSRHREWDLKCKVYVGNLGNNTARGDLEASFSKYGALKNVWVARNPPGFAFVEYEDPRDAEDAVRAMDGSRICGSRVRVEMSSGRARERNGPRGGGGGGDRGGDRRGGPRGGADFRGRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E9GK92</accession>
    <name>E9GK92_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_7063</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732549">
        <property type="protein sequence ID" value="EFX80100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80100"/>
    <dbReference type="EnsemblMetazoa" id="EFX80100">
        <property type="protein sequence ID" value="EFX80100"/>
        <property type="gene ID" value="DAPPUDRAFT_7063"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_7063"/>
    <dbReference type="eggNOG" id="KOG3802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013065_3_1_1"/>
    <dbReference type="InParanoid" id="E9GK92"/>
    <dbReference type="OMA" id="MALENFF"/>
    <dbReference type="OrthoDB" id="878553at2759"/>
    <dbReference type="PhylomeDB" id="E9GK92"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="POU-specific" evidence="10">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="99"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="101"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX80100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="161" mass="17821" checksum="169EE4FCFC04AD20" modified="2011-04-05" version="1" fragment="single">EETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLEDADSALGGGGNGSGAGGCGSSVSDGLGRRRKKRTSIETSVRVALEKAFLANPKPTSEEIAMLADGLSMEKEVVRVWFCNRRQKEKRINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKC8</accession>
    <name>E9GKC8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_244166</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732549">
        <property type="protein sequence ID" value="EFX79969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79969">
        <property type="protein sequence ID" value="EFX79969"/>
        <property type="gene ID" value="DAPPUDRAFT_244166"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_244166"/>
    <dbReference type="HOGENOM" id="CLU_2335737_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GKC8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX79969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="98" mass="11250" checksum="14BE5947CD064700" modified="2011-04-05" version="1">MWIKFVSDNSVQKAGFFAIFINGLNIVPVNRQDPVRVPTLIPLKVQKAKHKKFELKDEKSAIHFKWIIKGLSEKDSKAAREAFKPSLKHDKKYDGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKR5</accession>
    <name>E9GKR5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HYPK_UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_304277</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Ye Y."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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        <property type="term" value="P:negative regulation of apoptotic process"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
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        <source>
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    </evidence>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
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    <name>E9GPS2_DAPPU</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
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                <person name="Tsuchiya D."/>
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                <person name="Yamagata H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="220" mass="25389" checksum="3685CC88D7EC9774" modified="2011-04-05" version="1">METKYAQQKHELDDLKLRMNTGPTETGMEASDAYELHLARQAEIKELVKKIDNEYANYRNGTSDDKLIAFTRAKTIEVMLNKCHDEIWQRSTIDQRRDLRKQRAAADELLARMKNEQTATAAKHSGTAKPKLGLPTFDGDPMKYFGWVKQWNTYDEDTSIADTEKARLLEQCLTGKALESINDIPFSNDTYQNRKNRLEERYGSKPRVIALNKTGRIEKN</sequence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX78287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX78287"/>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="61" mass="6813" checksum="14D997F9D15D7E45" modified="2011-04-05" version="1">MDNFATPDVNKMAAKLNELESSVYQLLLKEKPTPPGLETFIGYADIKSALPSRVYVQRIAE</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in microtubule-mediated transport or vesicle function.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
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        <text evidence="4">Belongs to the huntingtin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="Huntingtin_fam"/>
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        <property type="entry name" value="Huntingtin_middle-repeat"/>
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    </dbReference>
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        <property type="entry name" value="SSF48371"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007153"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX77022.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="2402" mass="270495" checksum="627C36771CDD8002" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9GUF8</accession>
    <name>E9GUF8_DAPPU</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX76823">
        <property type="protein sequence ID" value="EFX76823"/>
        <property type="gene ID" value="DAPPUDRAFT_322048"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_322048"/>
    <dbReference type="eggNOG" id="ENOG502QUPU">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="E9GUF8"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="27"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76823.1"/>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <name evidence="2" type="ORF">DAPPUDRAFT_231232</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732574">
        <property type="protein sequence ID" value="EFX75643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75643"/>
    <dbReference type="EnsemblMetazoa" id="EFX75643">
        <property type="protein sequence ID" value="EFX75643"/>
        <property type="gene ID" value="DAPPUDRAFT_231232"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_231232"/>
    <dbReference type="eggNOG" id="KOG0814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_7_0_1"/>
    <dbReference type="InParanoid" id="E9GY10"/>
    <dbReference type="OMA" id="DYKGDTV"/>
    <dbReference type="OrthoDB" id="1203911at2759"/>
    <dbReference type="PhylomeDB" id="E9GY10"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="70"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="302" mass="33876" checksum="77410337300B1AF8" modified="2011-04-05" version="1">MSVFLVGRFCRQIVIHNSQIRNPFVLPLVQSFHLYTGRPSCVNPLVNSMIQQISVSEDFFFKQLFDRVSCTYSYLLADVKSKEAVLIDPVIDLAERDAKVVDNLGLKLKYSVNTHMHADHITGSGVLKKLLVGSQSVISKASQALADKYVEHGDIIEFGPHKLEVRSTPGHTNGCVTYVCHAQGMAFTGDALLIRGCGRTDFQEGSSETLYESVHNQIFSLPENFRLFPGHDYNGILDTTVSEEKKFNPRLTKCKEEFVELMKNLNLPYPAQIDKALPANKVCGLYNLPTEMEEKFKSILNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYY1</accession>
    <name>E9GYY1_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_108031</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732576">
        <property type="protein sequence ID" value="EFX75328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75328"/>
    <dbReference type="EnsemblMetazoa" id="EFX75328">
        <property type="protein sequence ID" value="EFX75328"/>
        <property type="gene ID" value="DAPPUDRAFT_108031"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_108031"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="1361949at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="192" mass="21247" checksum="EBD21F0C9B678F70" modified="2011-04-05" version="1">MSTLELEPLAIVWHGKVHRGGRSFEAGMHSVVDNTPFVLDIKEMPISLTMARTSVPADVGLYLENQNCLYGVIGDTSISKLPGKVKIFYAVPLAKESRMLLESPCYVKKSFRENRNSDYLIGIVETLPLALHTYSMERFSGHVAYTMAKYGMSIFVTGMAEEFRSDGIAVNALWPKSGTGKIFICIPVYASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9H1V6</accession>
    <name>E9H1V6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_200108</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0729 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX74301"/>
        <property type="gene ID" value="DAPPUDRAFT_200108"/>
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    <dbReference type="PhylomeDB" id="E9H1V6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026776">
        <property type="entry name" value="UPF0729"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14975">
        <property type="entry name" value="DUF4512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX74301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="81" mass="9523" checksum="7608F2866035B614" modified="2011-04-05" version="1">MVCIPCIVIPIFLYIWHRFLQPLFAKFWNPLSSKEDQKLKDQNDHKEQEEKKLSCPFSSSEASRQLPKNSDANEEVTKKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2J2</accession>
    <name>E9H2J2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_324718</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74055"/>
    <dbReference type="EnsemblMetazoa" id="EFX74055">
        <property type="protein sequence ID" value="EFX74055"/>
        <property type="gene ID" value="DAPPUDRAFT_324718"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_324718"/>
    <dbReference type="eggNOG" id="KOG2287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_440943_0_0_1"/>
    <dbReference type="InParanoid" id="E9H2J2"/>
    <dbReference type="OrthoDB" id="1673248at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:glycosyltransferase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:hexosyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX74055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="620" mass="66878" checksum="63D3BD7EEE01ABC7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9H549</accession>
    <name>E9H549_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1504978_0_0_1"/>
    <dbReference type="InParanoid" id="E9H549"/>
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    <dbReference type="PhylomeDB" id="E9H549"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="179" mass="21109" checksum="3F52D2277B475E10" modified="2011-04-05" version="1">MEDNVKEWETHHVFATAEHPQTSGLVDRVNRTMNQALEGYFNTDMMIGIAICRQQFLKSKQLDKLVYGRLPFTTLKNHFPCPKERPKPFDIFLARVGELREAARHNIIRKQEKSKRLVNQRRRIVRDLRPGELVLVRIKLKKKNKTKKYLPKYVGPFQVVKKICPTTYLVEDLPANRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5H4</accession>
    <name>E9H5H4_DAPPU</name>
    <protein>
        <recommendedName>
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        </recommendedName>
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    <gene>
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    </gene>
    <organism evidence="4">
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        <name type="common">Water flea</name>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX73000">
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        <property type="gene ID" value="DAPPUDRAFT_215690"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_215690"/>
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    <dbReference type="GO" id="GO:0005737">
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    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
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    </dbReference>
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        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="112"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX73000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="128" mass="14000" checksum="26E53392ED7ACFD0" modified="2011-04-05" version="1">MDEVERAKEAAAQPTPATTIFGKIIDGSIPAKIIYRDEKCLAFHDVSPQAPVHFLVIPIKPITMLEKAEADDLELLGHLMLTAKKVAADLNLNKGYRLVVNNGEEGCQSVFHLHIHVLGGRQLGWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5W5</accession>
    <name>E9H5W5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_253895</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732595">
        <property type="protein sequence ID" value="EFX72800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72800">
        <property type="protein sequence ID" value="EFX72800"/>
        <property type="gene ID" value="DAPPUDRAFT_253895"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_253895"/>
    <dbReference type="eggNOG" id="ENOG502QU73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046048_0_0_1"/>
    <dbReference type="InParanoid" id="E9H5W5"/>
    <dbReference type="OMA" id="YVRINCT"/>
    <dbReference type="OrthoDB" id="1177410at2759"/>
    <dbReference type="PhylomeDB" id="E9H5W5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="38"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="136"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX72800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="279" mass="31027" checksum="B07B95AEC0C9F7DC" modified="2011-04-05" version="1">MFYTAQTTSLREDHNQCRGGVLALKMVQVKVPLAALSGHSVQLECIFSLDGESLYAVKWYRGVDEFYRYVPAEEPHATVFGLNGIEVDLDESNANRLVLRSITAETAGRFRCEVSAEAPSFETVSGHADMTVVQLPQRGPVIAGGKPRYSVGDQVDLNCTSMRSSPATNLTWYINGEPAERHHLKFYPIVEDIDGLETSMLGLHFVIKTRHFRKGDLKFKCTATLAALYWQSNEASAEPDRPVHHQRSSSSEVYLDSHRTSTLASAALTVHFCVECDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6A3</accession>
    <name>E9H6A3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FoP_duplication domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_110449</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732597">
        <property type="protein sequence ID" value="EFX72730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72730"/>
    <dbReference type="EnsemblMetazoa" id="EFX72730">
        <property type="protein sequence ID" value="EFX72730"/>
        <property type="gene ID" value="DAPPUDRAFT_110449"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_110449"/>
    <dbReference type="eggNOG" id="ENOG502QV0X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_934671_0_0_1"/>
    <dbReference type="InParanoid" id="E9H6A3"/>
    <dbReference type="OMA" id="HMASAKN"/>
    <dbReference type="OrthoDB" id="1598721at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="FoP_duplication" evidence="3">
        <location>
            <begin position="195"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX72730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="298" mass="31748" checksum="09C7BA92DED83F87" modified="2011-04-05" version="1">MASGGRVPNNSTSLSLHERFSKLRSSAGGQKLAGKLQGARNNAANLQKASSKNSRLTQQMERRNASVSAALKLKKKSIKQRLGATVNTSTRFRGTATQTQRRLTTNRGAGRGSQRGSLRGSRTQGQTVTPTKIIRGRGGLKPIVSQTIVRGGGQGNKRSTRGRIISPSKKPAPVAATTNRSPTKPSRARGSVRGRRGGRGQMTSSLITGQAESRIQRGRGRGRGQRGGKGPSRGGSTLPTSPRGQTSGRGRGRGRGGSTKVSKEDLDKQLDQYMSKTRSVLDNDLESYMSKIGDVEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9H7Q1</accession>
    <name>E9H7Q1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cdk1/cdc2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_299546</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732601">
        <property type="protein sequence ID" value="EFX72219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72219"/>
    <dbReference type="EnsemblMetazoa" id="EFX72219">
        <property type="protein sequence ID" value="EFX72219"/>
        <property type="gene ID" value="DAPPUDRAFT_299546"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299546"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="E9H7Q1"/>
    <dbReference type="OMA" id="NNDVWPE"/>
    <dbReference type="OrthoDB" id="1010560at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX72219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="305" mass="35152" checksum="A9333AFC2C132FA2" modified="2011-04-05" version="1">MPSAMEDFTKIEKIGEGTYGVVYKAKNRKTQQFVAMKKIRLENEDDGVPSTAIREISLLKELLHPNIVCLEDVLMQEGKLYLIFEFLSMDLKKYMDSIPTGQLMDKTLVKSYCHQILEGILYCHRRRVLHRDLKPQNLLIDKNGIIKIADFGLGRVFGVPVRVYTHEVVTLWYRAPEVLLGSSRYSCPIDVWSVGCIMAEMITKKPLFQGDSEIDQLYRIFRVMKTPTEEMWPGVSKMPDYKPTFPNWNTYHLQNSVKQLDSIGFDLLQKTLIYDPALRITAQDALDHAWFTDLDKSILPTNVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9H7U8</accession>
    <name>E9H7U8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_326467</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732602">
        <property type="protein sequence ID" value="EFX72092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72092"/>
    <dbReference type="MEROPS" id="C13.005"/>
    <dbReference type="EnsemblMetazoa" id="EFX72092">
        <property type="protein sequence ID" value="EFX72092"/>
        <property type="gene ID" value="DAPPUDRAFT_326467"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326467"/>
    <dbReference type="eggNOG" id="KOG1349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044656_1_0_1"/>
    <dbReference type="InParanoid" id="E9H7U8"/>
    <dbReference type="OMA" id="PGHTNNW"/>
    <dbReference type="OrthoDB" id="1259741at2759"/>
    <dbReference type="PhylomeDB" id="E9H7U8"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="PTHR48067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027752599" evidence="8">
        <location>
            <begin position="20"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX72092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="347" mass="39320" checksum="19482B09DF940076" modified="2011-04-05" version="1">MIIASLYYFVALLISNTHAWDAQASNFLTSGDHTSNWAVLVDTSRFWFNYRHVANVLSIYRSVKRLGIPDSQIILMIADDMACNPRNPHPAAVYNNANQQIDVYGDDVEVDYRGYEVTVENFIRVLTGRLPASTPRSKKLLTDAGSNVLIYLTGHGGDGFLKFQDSEEITNVDLADAIQQMWEKQRYHEMLFIVDTCQAASLYQKFYSPNVLAIGSSLVGEDSLSHHVDPAIGVYIIDRYTYYALEFLEHVTPSSNHTLGQFLKVCPKYLCLSTVGFRSDLFQRDPNRVFITDFFGSQKRIEMAADPIVLPSPSNKETSLPHREEVPRRTLYYADPIPPLCIHSLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9H830</accession>
    <name>E9H830_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb_DNA-bind_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_111091</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732602">
        <property type="protein sequence ID" value="EFX72142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72142">
        <property type="protein sequence ID" value="EFX72142"/>
        <property type="gene ID" value="DAPPUDRAFT_111091"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_111091"/>
    <dbReference type="HOGENOM" id="CLU_757078_0_0_1"/>
    <dbReference type="InParanoid" id="E9H830"/>
    <dbReference type="OrthoDB" id="1178708at2759"/>
    <dbReference type="PhylomeDB" id="E9H830"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb_DNA-bind_4" evidence="2">
        <location>
            <begin position="207"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX72142.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="366" mass="41454" checksum="466A0A3155174FC2" modified="2011-04-05" version="1">MSSEFGMGSSVIKYNFPCGGIVYLRVTEETKLRYQTDSCYKAEIDAKAYQHFLEKEEQRRRTEEKETKLDEELKLKETNSQPNHTSESSEEDDAATNKQKFPIGAASRVRVENGVISVAPKPTASRKRSTFTGKKVSKGPTPSVKKRRVGPLVSDRDEEPKPSSSTIENNSDEIDDMGIEKCLEKESDQDVALEDSGSDEGGGDPGKWTTKEVSLLLDIYHKYKSQFDEPYAVKFRIWNKICKIPEIAATGKSSVQLSKKIDNLKKTWRKMNRPGAKASQQWKWTEQMDLIFGDDPTIELNHVAEVGDRGPKKTATSSTNSSNWKTQLINIEKERVDVLKDIARSQVKKSETFDRLTSLIEKWSQK</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_326913"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326913"/>
    <dbReference type="HOGENOM" id="CLU_1994913_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9H958"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
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        </location>
    </feature>
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        <location>
            <begin position="50"/>
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        </location>
    </feature>
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        <location>
            <begin position="66"/>
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        </location>
    </feature>
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        <location>
            <begin position="98"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="125" mass="14290" checksum="0183CD663E2D88EB" modified="2011-04-05" version="1">MDYTLDYYRCGKCQSTHYSWLLIYEKHLKYRETSDDESSDKEDVTPDVESSQGESDSYGDLSSGNDTRDDSGESEEERERKRKKANRTKKAKKAKLALEANNNTSDEDSDLSSAFSDCSLDEDNE</sequence>
</entry>
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    <accession>E9HBG2</accession>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_256482"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_256482"/>
    <dbReference type="HOGENOM" id="CLU_2006197_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="EFX70837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="124" mass="14221" checksum="44DB0FBE9F57435F" modified="2011-04-05" version="1">MGRDKDRYEISAKRTLAILLTLSNQGFVINTFTISSLILALNLLPTIISADNSRYTQARFNRFNPHLTVLYKMKYQYIKLKLAKAPKYSIFTGKERAVSRLVRLQRDEDVFGAHVLAILSEKVV</sequence>
</entry>
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    <accession>E9HCG6</accession>
    <name>E9HCG6_DAPPU</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732620">
        <property type="protein sequence ID" value="EFX70512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70512">
        <property type="protein sequence ID" value="EFX70512"/>
        <property type="gene ID" value="DAPPUDRAFT_328085"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_328085"/>
    <dbReference type="eggNOG" id="ENOG502QSMG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1526758_0_0_1"/>
    <dbReference type="InParanoid" id="E9HCG6"/>
    <dbReference type="OrthoDB" id="1357402at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="176" mass="20734" checksum="CAED98FD67748477" modified="2011-04-05" version="1">MAGKTKNVKLAQFMLKHRGLNRGRVMTGRSVHNQRIERLWVDVYNGVMHVFQSLFLELERRLLLDPDSEEDLFCLHHIFLAVIHTFVDEFVGSWNRHGLRTDIDLNEDLPDFTDVEDVEQLHVPPIEVTIDRATQRRLRRKYGMILSRLKIAKRNYLKMRNENEKLRAAINSNSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDC8</accession>
    <name>E9HDC8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">40S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_300540</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732623">
        <property type="protein sequence ID" value="EFX70268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70268"/>
    <dbReference type="EnsemblMetazoa" id="EFX70268">
        <property type="protein sequence ID" value="EFX70268"/>
        <property type="gene ID" value="DAPPUDRAFT_300540"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300540"/>
    <dbReference type="eggNOG" id="KOG0900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_0_0_1"/>
    <dbReference type="InParanoid" id="E9HDC8"/>
    <dbReference type="OMA" id="MANIKKD"/>
    <dbReference type="OrthoDB" id="1454256at2759"/>
    <dbReference type="PhylomeDB" id="E9HDC8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_S10_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX70268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="118" mass="13156" checksum="B835F24C3529F11F" modified="2011-04-05" version="1">MAYKDTGKPVAEEAVIHKIRITLTSRNVPSLEKVCSELVGAAKDKNLRVKGPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRIIDLQSPAEIVKQITSFSIEPGVEVEVTIADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9HEH1</accession>
    <name>E9HEH1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dystroglycan 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dystroglycan</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Dystrophin-associated glycoprotein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DAPPUDRAFT_300674</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732629">
        <property type="protein sequence ID" value="EFX69846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69846"/>
    <dbReference type="MEROPS" id="S72.001"/>
    <dbReference type="EnsemblMetazoa" id="EFX69846">
        <property type="protein sequence ID" value="EFX69846"/>
        <property type="gene ID" value="DAPPUDRAFT_300674"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300674"/>
    <dbReference type="eggNOG" id="KOG3781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_310406_0_0_1"/>
    <dbReference type="InParanoid" id="E9HEH1"/>
    <dbReference type="OMA" id="LTTERNP"/>
    <dbReference type="OrthoDB" id="163609at2759"/>
    <dbReference type="PhylomeDB" id="E9HEH1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016011">
        <property type="term" value="C:dystroglycan complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021675">
        <property type="term" value="P:nerve development"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008465">
        <property type="entry name" value="DAG1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030398">
        <property type="entry name" value="SEA_DG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05454">
        <property type="entry name" value="DAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51699">
        <property type="entry name" value="SEA_DG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003238339" description="Dystroglycan 1" evidence="17">
        <location>
            <begin position="24"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="795"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S72" evidence="18">
        <location>
            <begin position="398"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S72" evidence="18">
        <location>
            <begin position="650"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="852"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="852"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="893"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFX69846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="948" mass="105121" checksum="E094C0A11D57C62D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGC2</accession>
    <name>E9HGC2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_62484</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Zdobnov E.M."/>
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    </evidence>
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        <source>
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    </evidence>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Thomas W.K."/>
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                <person name="Pritham E.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="PhylomeDB" id="E9HK79"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="171" mass="18841" checksum="8FD2703DBA09C2A4" modified="2011-04-05" version="1">MEKGSYTQFNLQTRRPVCISFTLEGRGKHCTQPQQRQPKEGKAINYGVFLLLGVESLTVGSTTGVPMSPGPVYGNAEETSRRWILSSFTVVTGLRRMLPLSWCERNSVESRPTPRLVINVDHRIVVNPLSATPLFSPARAALVGLVVYKPRGRRVAKPKICRKAPVSGNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9HN65</accession>
    <name>E9HN65_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_115985</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732693">
        <property type="protein sequence ID" value="EFX66826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66826">
        <property type="protein sequence ID" value="EFX66826"/>
        <property type="gene ID" value="DAPPUDRAFT_115985"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_115985"/>
    <dbReference type="HOGENOM" id="CLU_1241230_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX66826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="223" mass="24969" checksum="9261F38F87EB6DA2" modified="2011-04-05" version="1">MSAQYLTDANRGIPSHDGASTRGADAYAQHTNSPTPSLVSATLPSNDNITMHQSPENYSSRVEQGFSQSSYYSNTFARRDGTSHFIPNPVAPISQNEGFVSCKEFQVIIQGIARMTVLSQDISNQLKVISTRLSKLEEERGTMETSDDLTMPKFPLETLQDFDIFEAKLKDEAFKKAFCFSVARKRMDPIRIEELFYLLLIHKIPSHNALARGPLCRADDKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNF0</accession>
    <name>E9HNF0_DAPPU</name>
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        <recommendedName>
            <fullName evidence="1">Receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.1</ecNumber>
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    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_302458</name>
    </gene>
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        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.10.1" evidence="1"/>
    <dbReference type="EMBL" id="GL732695">
        <property type="protein sequence ID" value="EFX66756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66756"/>
    <dbReference type="EnsemblMetazoa" id="EFX66756">
        <property type="protein sequence ID" value="EFX66756"/>
        <property type="gene ID" value="DAPPUDRAFT_302458"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302458"/>
    <dbReference type="eggNOG" id="KOG0200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_7_40_1"/>
    <dbReference type="InParanoid" id="E9HNF0"/>
    <dbReference type="OMA" id="WSIQIAN"/>
    <dbReference type="OrthoDB" id="1152251at2759"/>
    <dbReference type="PhylomeDB" id="E9HNF0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033674">
        <property type="term" value="P:positive regulation of kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:transmembrane receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001824">
        <property type="entry name" value="Tyr_kinase_rcpt_3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00240">
        <property type="entry name" value="RECEPTOR_TYR_KIN_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX66756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="423" mass="47797" checksum="B54EF68502BA2998" modified="2011-04-05" version="1">MNDDLSLDDQIEILPYDRRWEFPRNRIKLGVQLGAGCFGRVVKAEAVGVKDSEENVQTVAVKMIKSQTNVAALEALVSELKIMIYLGGHLNIVNLLGACTKTLVRRELFVIVEYCRFGNLQSYLINHRNNFEDPLEDPDTKFHGLIMSTADLISWSFQIARGMDYLASKKVLHGDLAARNVLLADDGVAKVADFGMSRKMYYEGNYKQSGQKLMPIKWMAIESLTDRIFSTQSDVWSYGVLLWEIFTLGKVPYPGLEGNHQLVRQLEKGYRMDKPDFAPNYIGEIMSSCWKIDPKERPSFSEMEEMISSQMESTVSDHYLNLNSSYEKLNELKVSASPTEPLGLAKALDTKEKVGKRHSIFSRIITQTKIDPKKLSSRNSSGQVESNKESKNLPCNVNSNTKSLISQIKRRGFSFHQDLAGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNI3</accession>
    <name>E9HNI3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
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        <name type="common">Water flea</name>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732696">
        <property type="protein sequence ID" value="EFX66673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66673">
        <property type="protein sequence ID" value="EFX66673"/>
        <property type="gene ID" value="DAPPUDRAFT_302469"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX66673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="134" mass="15255" checksum="3709A15047F90D6B" modified="2011-04-05" version="1">MDTNNGQLKRILNSTLANESEFTVNTKLTENSMSEDVNSPWESVIIAATVSLVGMILLVMLYGFHHFCKRKRQTMVMPVITQSGLIPDYFTRPREPVVFDNEVSGHALIQETVTYWHRPLQPVTTDTDLYPIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HP87</accession>
    <name>E9HP87_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_263169</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732704">
        <property type="protein sequence ID" value="EFX66394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66394">
        <property type="protein sequence ID" value="EFX66394"/>
        <property type="gene ID" value="DAPPUDRAFT_263169"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_263169"/>
    <dbReference type="HOGENOM" id="CLU_2576250_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX66394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="81" mass="9441" checksum="9BFECD74BE3A1C3D" modified="2011-04-05" version="1">MHGSMKTELIHFTMFMCTEIGMDCAGKGFNLHKQGMIVKDSDIGRRKLLLKFIQLAIVIFYRKMASSLSRDIRYPRIVESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPE6</accession>
    <name>E9HPE6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_116444</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732705">
        <property type="protein sequence ID" value="EFX66370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66370">
        <property type="protein sequence ID" value="EFX66370"/>
        <property type="gene ID" value="DAPPUDRAFT_116444"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_116444"/>
    <dbReference type="HOGENOM" id="CLU_2266376_0_0_1"/>
    <dbReference type="OrthoDB" id="294726at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="PTHR10237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX66370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="103" mass="11877" checksum="FB5F428374F39E2C" modified="2011-04-05" version="1">MARSHLKLYISVNSGATGKMENAINVDIFSTIIDELASNLERSIGLEGLNDTARQNIREEAKRYFEKGSCRFENYTKIVFLNLTMLDHTTFHWTLHYSLCPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPU3</accession>
    <name>E9HPU3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear apoptosis-inducing factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Regulatory protein zeste</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_332385</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Induces apoptosis.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732711">
        <property type="protein sequence ID" value="EFX66218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66218">
        <property type="protein sequence ID" value="EFX66218"/>
        <property type="gene ID" value="DAPPUDRAFT_332385"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_332385"/>
    <dbReference type="HOGENOM" id="CLU_925186_0_0_1"/>
    <dbReference type="InParanoid" id="E9HPU3"/>
    <dbReference type="OrthoDB" id="1131373at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026753">
        <property type="entry name" value="NAIF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="PTHR23098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb_DNA-bind_5" evidence="11">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX66218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="301" mass="32896" checksum="12CCF7E1336B4B7F" modified="2011-04-05" version="1">MVRNASATWSSSETEILVDELIARKDVIFGAQSSTVTNKIKQQHWDEIVATINQQFPSQHPRDREETKKKWNNLSSDARKNLKEHKNSVEQTGKGKAFPMKPLNEKIVNMIWGESSAALPGNSISGGVETDVMENANDTLLINNSAASASLHTMNASSCTFLAKTVQSSFLVNEEDDLSAFEFDDSQSNQSSLCQTFSNADFADGVPSTSRVVALLPKRTSTPVLSTKTTDHSSANIVFAKRSQATLAPVEKYAPLVAVTSSSTTNGESLNKNPLALRDIVAQFAPKEHMLKNQTFLFLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPW6</accession>
    <name>E9HPW6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ovo/shavenbaby-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_290491</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732712">
        <property type="protein sequence ID" value="EFX66214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66214"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_290491"/>
    <dbReference type="eggNOG" id="KOG3576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087964_2_1_1"/>
    <dbReference type="InParanoid" id="E9HPW6"/>
    <dbReference type="OMA" id="HESAFPC"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009913">
        <property type="term" value="P:epidermal cell differentiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027756">
        <property type="entry name" value="Ovo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10032">
        <property type="entry name" value="PTHR10032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX66214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="144" mass="17215" checksum="8351F2F6C2EC3FA6" modified="2011-04-05" version="1" fragment="single">KSFTLQRLLNRHMKCHSDVKRYLCTFCGKGFNDTFDLKRHTRTHTGVRPYKCALCEKSFTQRCSLESHCLKVHGVAHQYQYKERRAKEVYVCEECGHTTNEPEVHYVHLKELHPYSPALLKFYDKRHFKFTNNNFTNMLLQVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9HQR4</accession>
    <name>E9HQR4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_263999</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732724">
        <property type="protein sequence ID" value="EFX65918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65918">
        <property type="protein sequence ID" value="EFX65918"/>
        <property type="gene ID" value="DAPPUDRAFT_263999"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_263999"/>
    <dbReference type="HOGENOM" id="CLU_1628696_0_0_1"/>
    <dbReference type="InParanoid" id="E9HQR4"/>
    <dbReference type="PhylomeDB" id="E9HQR4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="SSF57756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX65918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="163" mass="18344" checksum="3017DFC5B3D76642" modified="2011-04-05" version="1">MEQLTESMMNLGGLLSSSIQKDISRNQQRGGQSNGYNQQNQSSFFNPAPQNNFNTLRPGNRFQQLPSGPPAETFNSSGHSSLIPLPHFTQTNLSQQQLAPPSHCPTSQFHQLPQPFLQTTQHQPSQLSEEPYSSPKFGSERRLCYSCRQRGHEIKDCPDRISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9HRC6</accession>
    <name>E9HRC6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_37832</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="entry name" value="Znf_PHD"/>
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        <location>
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        </location>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX65710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="55" mass="6617" checksum="CAF7A0BD6D6EF5C8" modified="2011-04-05" version="1" fragment="single">DPDRLWCVCREPHNNRFMICCDKCEEWFHGTCVGITRSMGRELELKKLEWICPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9HS89</accession>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732746">
        <property type="protein sequence ID" value="EFX65398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX65398"/>
    <dbReference type="EnsemblMetazoa" id="EFX65398">
        <property type="protein sequence ID" value="EFX65398"/>
        <property type="gene ID" value="DAPPUDRAFT_117307"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG4177">
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX65398.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="242" mass="27882" checksum="7C0D777CCB8D4082" modified="2011-04-05" version="1">MGTYSMAKSYRRANIEDYNPWNETALFIAVRLNRMRMAEDLIARYASIMPEDTMGRTVAEILISIDDVETLKLLHIQRGNLLDHDLHNEEFPLTLAISHQARKCIDYILSLKPKAQSFLIRRKYNCPISAAIRRNDVRTMEQLVTLEEFPYIVNKRITKSVSYIHLAVEKGRPEIVKILLQNGALVNLLDNNGNTPVHYVSDIPILKILIAHKARLDVVNNFDFTPIMSAAKDQRNSIYQYL</sequence>
</entry>
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    <accession>E9HST3</accession>
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        <recommendedName>
            <fullName evidence="1">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_8948</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Rho M."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Tang H."/>
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                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732757">
        <property type="protein sequence ID" value="EFX65198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX65198"/>
        <property type="gene ID" value="DAPPUDRAFT_8948"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_8948"/>
    <dbReference type="eggNOG" id="ENOG502STY9">
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    <dbReference type="OrthoDB" id="1574448at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:BMP binding"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="73" mass="8417" checksum="4FB162B362A78C34" modified="2011-04-05" version="1" fragment="single">CHFGKKVYELEERWNPDLGSPFGVMYCIRCECIAVQKKRRIAGRTLCRNIKNECPKPNCDEPVLLPGRCCKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9HV75</accession>
    <name>E9HV75_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_118260</name>
    </gene>
    <organism evidence="2">
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        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Koonin E.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
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    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
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        <property type="term" value="F:syntaxin binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="PTHR45701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX63331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="86" mass="9929" checksum="7454DB96EF00112D" modified="2011-04-05" version="1" fragment="single">MDKSKNRINSRQLDILHGQMDDVLKVMKENTKRVLDRGHRLHELSERAEALEQQATIFVKSATQVKKKAKFRAAKWTLILAGFVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HYF5</accession>
    <name>E9HYF5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_268825</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733148">
        <property type="protein sequence ID" value="EFX63225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63225">
        <property type="protein sequence ID" value="EFX63225"/>
        <property type="gene ID" value="DAPPUDRAFT_268825"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_268825"/>
    <dbReference type="HOGENOM" id="CLU_1688545_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="156" mass="17408" checksum="C1F21EDD51B490C0" modified="2011-04-05" version="1">MPSSTSRSRSLDIDIRRYRGNPRASLDSRVENVWFLCRQLEIAVRVVVHLEAGREVHLVADHVIDLIADRVSLLARFLHEVPDLHGVIDDHVPDLLDAVTVHLPVMHDEMIVHGPRFAGVTDPPVVIALGLLVSLLLQIRLLGFPVKKSVLFARGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9HYY0</accession>
    <name>E9HYY0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_336006</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS35L family.</text>
    </comment>
    <dbReference type="EMBL" id="GL733239">
        <property type="protein sequence ID" value="EFX63051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63051">
        <property type="protein sequence ID" value="EFX63051"/>
        <property type="gene ID" value="DAPPUDRAFT_336006"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_336006"/>
    <dbReference type="HOGENOM" id="CLU_2087248_0_0_1"/>
    <dbReference type="OrthoDB" id="276568at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029705">
        <property type="entry name" value="VPS35L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673">
        <property type="entry name" value="PTHR13673"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX63051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="117" mass="13141" checksum="0096FD959FCAE3B4" modified="2011-04-05" version="1">MNSNIAWDLDQRVKALKTVIQGSILLLKTHLFAFYPSKFITHILDNFGRMDCWFRKMDASRMDSPVIGSEKMKKLGLLPLQKGSSRDYDENGSNSSMLNECAAAAFHNGDSLLQGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZH6</accession>
    <name>E9HZH6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_336329</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733339">
        <property type="protein sequence ID" value="EFX62854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62854">
        <property type="protein sequence ID" value="EFX62854"/>
        <property type="gene ID" value="DAPPUDRAFT_336329"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_336329"/>
    <dbReference type="HOGENOM" id="CLU_2308851_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HZH6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX62854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="100" mass="11284" checksum="B19F7129E2576A06" modified="2011-04-05" version="1">MNYDGDCEDGPEDDQDKDQDKTEKDEPKSKKVEEATSAETKVEEKNAGNVAGPSHWKKRQSRKKELKNAKKPRTEASTEVNTTLANEFKKYCNSSSDDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZI6</accession>
    <name>E9HZI6_DAPPU</name>
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        <recommendedName>
            <fullName evidence="4">Superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">VTG1</name>
        <name evidence="14" type="ORF">DAPPUDRAFT_299677</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="GL733346">
        <property type="protein sequence ID" value="EFX62844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX62844"/>
    <dbReference type="EnsemblMetazoa" id="EFX62844">
        <property type="protein sequence ID" value="EFX62844"/>
        <property type="gene ID" value="DAPPUDRAFT_299677"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299677"/>
    <dbReference type="eggNOG" id="KOG0441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002920_0_0_1"/>
    <dbReference type="InParanoid" id="E9HZI6"/>
    <dbReference type="OMA" id="AKECERE"/>
    <dbReference type="OrthoDB" id="36651at2759"/>
    <dbReference type="PhylomeDB" id="E9HZI6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="PTHR10003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF49329"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003238437" description="Superoxide dismutase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="12">
        <location>
            <begin position="251"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="13">
        <location>
            <begin position="1684"/>
            <end position="1893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFX62844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1999" mass="224834" checksum="22A64F9DB5127A94" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZQ6</accession>
    <name>E9HZQ6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_119876</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
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        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX62773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="165" mass="18030" checksum="4834168344F82BFE" modified="2011-04-05" version="1" fragment="single">NLKFVNWQTHAIKETNSASLVTLGSWSEHAQSDAYEQSRNYYTDACLLAAGGRSLGTLDFYQFHTYTYTGQWDPSEPFKVTATSYKLDKPLVIGEFATVCGGPESSPTLFQYSYDNGYQGVWSWSYNGGPTGSTCCDNQTTQDSGMLQLKGQNGAGGAVNFPIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9I051</accession>
    <name>E9I051_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_270072</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Krijgsveld J."/>
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                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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    </evidence>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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    </evidence>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Arnold G.J."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="166" mass="18273" checksum="6D1DD533BE5136DC" modified="2011-04-05" version="1">MTTQKLPTKIFFVVFQHLALLVINAGRNNKRLRSEVAAKLKLAASASVPAVPTMATTLPAASLPSAPSIPNMLNFGPPAPINPYASLQSYYYPPQHQIVSSLSSMVPYMIPQSQQQQQTSQHQQQQPQQQTVTYSHSEPLPPGTQHQGEDDSLSAIAANKRKRQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="1">DDE_Tnp_IS1595 domain-containing protein</fullName>
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        <name type="scientific">Daphnia pulex</name>
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        </lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL737090">
        <property type="protein sequence ID" value="EFX60123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX60123"/>
        <property type="gene ID" value="DAPPUDRAFT_19746"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
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        <property type="entry name" value="DDE_Tnp_IS1595"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS1595" evidence="1">
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            <begin position="29"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
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            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12762"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX60123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="98" mass="11038" checksum="BE5E13C4C085633D" modified="2011-04-05" version="1" fragment="single">IDWANFCREVAEDIVINNSEKIGGVGVVVEIDESKFGKRKYNRGKRVDGVWVFGGVERETGKCFLVVVQNRTATTLLAVIKEWIKPGTTIISDCWKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="2">HMG box domain-containing protein</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="DNA-binding region" description="HMG box" evidence="1">
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    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX90219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="86" mass="10488" checksum="EC1C1A9B601C1D3D" modified="2011-04-05" version="1" fragment="single">MSNLNNDHIKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKMLTELEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKS</sequence>
</entry>
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    <accession>E9FRU8</accession>
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    </protein>
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    <organism evidence="3">
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="4"/>
            <end position="151"/>
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        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX90419.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="387" mass="42958" checksum="2B61D2E4CDB28846" modified="2011-04-05" version="1">MLLGGKGVGKSTLLRYLLNQLIQKCGTVLVVDFDPGQPEFFPAGCVTASLVSEPLLGPNFTHIQQPLFSYFVGDADIIGCPERYVRSCRQLLIDCKLKFALENVPTLINTMGFTSGIGLDVTLDLIRLTQPHQLLQISSRSLRRNFPSMLERDYVAQHQRGWLTDAAEWSEKLPNYELQAIYSSAELSEKSLEEWGFRASELRQIGLMSYFSQLSNSSGWSLMDSVPYCISWQDLAVCICHESVPPALTMAALNASLVALCILDNDAAASVPYYQAADGKYPKILRELPLMPCLGYGIIRGIDLERGRVYLISPEPAERLAHVNCLVMGGVRVPESLLLDAPLSVNQDEECVTKLRVPYGTFGPSVAQPACRPYRKYNPVFTLRNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSI0</accession>
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        <name type="scientific">Daphnia pulex</name>
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        </lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <end position="95"/>
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        <location>
            <begin position="69"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX89210.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX89221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_32451"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CBAR/FAM92"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX89221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="216" mass="24707" checksum="240B90DA6F7373CA" modified="2011-04-05" version="1" fragment="single">QTRFIQNRIQVIEKHFGEICTALALYTRKIAGLRDKGDFLAQTLNDYATAENVNKNCSQGIKDFADNISFISDYRDVCVNRLEETVIQEISSYAGVCKSAMEDVRSCSIAYEKEISQLKYVHKLRQQNPLGRMQISKAESDLAHATTQSVRLGKSIEERADKLEKKKLKDLISWMKRLALIEMSFHSTSLSVLTKAYQQLENVDVESDLEEFRNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUQ3</accession>
    <name>E9FUQ3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_304777</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88769">
        <property type="protein sequence ID" value="EFX88769"/>
        <property type="gene ID" value="DAPPUDRAFT_304777"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304777"/>
    <dbReference type="HOGENOM" id="CLU_608686_0_0_1"/>
    <dbReference type="InParanoid" id="E9FUQ3"/>
    <dbReference type="OrthoDB" id="1751314at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX88769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="450" mass="51213" checksum="A0299E60D548016B" modified="2011-04-05" version="1">MEIIRQNSEVVDEDFKDFNLSFEKFIETKNSSFMEIRERLQDKQFCLTSSVEALQRATIEKSSLENEISGLRTEKMEFENKIKTLTENSVTSESTQEKLRNRNAVLENMKSSASQQILDLQKRVHSVEAELALSNGKAQELAKEKSSLENQLGSLRHQLQASQDKSEKTIRMLIADKEELEKSTKKLTETTAKWKSTHEQMCNRNSALNSSVASSNQQISDLQQSVDALETKLKSSNEKFNDLDVDKKNLESHLGSLRDQLQVCQEKSSRDLEKLRTQMEIERASHEDYKTRLGVTVSNPQESKVLTNEIKHGCPKVASKLSKRFVNDNQNSNAQRNEMLSAPSVFTNEEFQRRPLNDCRKQLETGETSHKNQSNNSGNPSNEFGLANCLEDTVNISSENKDAEKRGSKTLATDGENKPVKIIEESPPSATRKFLQEVRRLLPNDHFPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9FWI5</accession>
    <name>E9FWI5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4502 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_95973</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX87899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87899">
        <property type="protein sequence ID" value="EFX87899"/>
        <property type="gene ID" value="DAPPUDRAFT_95973"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_95973"/>
    <dbReference type="HOGENOM" id="CLU_712236_0_0_1"/>
    <dbReference type="OrthoDB" id="326023at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028026">
        <property type="entry name" value="DUF4502"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14950">
        <property type="entry name" value="DUF4502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4502" evidence="2">
        <location>
            <begin position="158"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX87899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="388" mass="42445" checksum="E2FA802FA69B126A" modified="2011-04-05" version="1">MEESNSPVLSCKKFGKKTHVLPESPILSCGRKRKKPLPDDSPVFLRTTRTIKSCDESPVIDSFSSPPPIAKLKPKSLFPEVDDAPPSVESQLSQASSSKCNDHIIDEEDSSSTGSEDDLIVHERTMSDSEDRLDIPDNARSQNSISISQTLSYYSGISTPEKKVAKAKPVATGNGLAKQLSKLLVRQESDYHLWKFQQKLGSSKTDADPATTTKMLRLRIESLSPGNMHSLAHCRNLAASSATTSRGEGSLSNRVSLVFTPERWERFSSVRSGDIVSIYEPWQSMELVGGVTLLLDFNLLLLSKEKKKKEEVSKLSNSSDSDALRLGATNDSPTVEDLTDADGRACSSASADSIAVAENRRPSTVTVLQTWTCPCQVRPINQRVPFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYX1</accession>
    <name>E9FYX1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_42928</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87608"/>
    <dbReference type="EnsemblMetazoa" id="EFX87608">
        <property type="protein sequence ID" value="EFX87608"/>
        <property type="gene ID" value="DAPPUDRAFT_42928"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_42928"/>
    <dbReference type="eggNOG" id="KOG3316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076409_3_1_1"/>
    <dbReference type="InParanoid" id="E9FYX1"/>
    <dbReference type="OMA" id="RTNHHGV"/>
    <dbReference type="OrthoDB" id="1566836at2759"/>
    <dbReference type="PhylomeDB" id="E9FYX1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043087">
        <property type="term" value="P:regulation of GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="PTHR12817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX87608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="157" mass="17813" checksum="B0D6654AA8F069D8" modified="2011-04-05" version="1">MADDALFDFLHMEIVSQVTKSDPGSLQDGVTMSKLEQIGYSTGYRFIERLTKDLSRFKDELEVMKAICKDFWSAVFKKQVDNLRTNHQGVYVLQDNKFRFLASISNSRQYLELAPKYLVFTCGLLRGALASLGLTCIVTAEVTTMPACKFQVHLQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZV1</accession>
    <name>E9FZV1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_312661</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87116">
        <property type="protein sequence ID" value="EFX87116"/>
        <property type="gene ID" value="DAPPUDRAFT_312661"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312661"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="134" mass="14912" checksum="9C494BF4E2C988B1" modified="2011-04-05" version="1">MNLRSRFPTPPLLVNPKMRTNSLSLNLNRCLYVTDTGIQWLCNVDYPRMGNGKSGLCGTIKKLCICYTAVTQQGIQVALTHLQSLNILESFDILEALVLRQLKICKSNLWVPNDTEITFDGGVAPLLKGRYGLA</sequence>
</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Yamada T."/>
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                <person name="Lucas S.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="107" mass="12178" checksum="388FA9F0F3A75319" modified="2011-04-05" version="1">MLTVAAAWTFSRKPAPEVQKSPTAKATVQLNIQPFTAASAPRKEKEKKTRTKTRFHSRSDWNNRFGKVDKTTTMSSRQAIGIQSLPNETPRYKKKAFLSSNRRFPIP</sequence>
</entry>
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    <accession>E9G1J2</accession>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        </location>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX86803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="140" mass="15366" checksum="89E08E890DF00B98" modified="2011-04-05" version="1">MCKAAIRGALSLSFLSIASSSSLHSRAELRPVRSHSEKSLIFLQTTHFFFSLLFVILKIKKFFSDRKYDPTELTERNSVHGRRPSSSSSTPSKSPRVLVTSTTNDTGVCLISDIAQVSVVPRECVCECTCVSAIALEGRP</sequence>
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    <accession>E9G1J4</accession>
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        <submittedName>
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    <organism evidence="3">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86505">
        <property type="protein sequence ID" value="EFX86505"/>
        <property type="gene ID" value="DAPPUDRAFT_236223"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_236223"/>
    <dbReference type="HOGENOM" id="CLU_1983822_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX86505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="126" mass="14215" checksum="3B7D1D7C021F735B" modified="2011-04-05" version="1">MRGSQIISSVLYYTAAIELLCAESSSKLACQNHSSGRYDHTSQKKDLTWLSTTHSKAYCLPTCALCSDLDFCAQPSTDGHPKCYYTTTSRQTPPRRSHRTEEEDEEEVDDAQIIIMIIFATYTYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1R2</accession>
    <name>E9G1R2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_236316</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86771"/>
    <dbReference type="EnsemblMetazoa" id="EFX86771">
        <property type="protein sequence ID" value="EFX86771"/>
        <property type="gene ID" value="DAPPUDRAFT_236316"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_236316"/>
    <dbReference type="eggNOG" id="KOG0789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1171681_0_0_1"/>
    <dbReference type="OrthoDB" id="251520at2759"/>
    <dbReference type="PhylomeDB" id="E9G1R2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX86771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="237" mass="26264" checksum="B42CA99E6C1DAA3C" modified="2011-04-05" version="1">MITNQWNADEENVICVDPKEGWKLAELFQVKLVNEDVRATYIIRTFSMKHLKLKKKKSQSAERVVLQFHYTNCSDHGTPEHPLPILSFVRQSAAVNPIGAGPIIVHSSARVGRTGTYISGLPASLLSDKTIGSNLAACTLDTTTTTMTMNSIGSQEDLWLLLDQFHLVTNLLVQDFHLSSAVKNCSVHINRNAALLSVESASVYLTPQRGVEGSENIYATWLQGYPKLRVYRYSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1Z5</accession>
    <name>E9G1Z5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_236433</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86576"/>
    <dbReference type="EnsemblMetazoa" id="EFX86576">
        <property type="protein sequence ID" value="EFX86576"/>
        <property type="gene ID" value="DAPPUDRAFT_236433"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_236433"/>
    <dbReference type="eggNOG" id="ENOG502QSH9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055700_1_0_1"/>
    <dbReference type="InParanoid" id="E9G1Z5"/>
    <dbReference type="OrthoDB" id="1535514at2759"/>
    <dbReference type="PhylomeDB" id="E9G1Z5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042477">
        <property type="entry name" value="HMGXB4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46584">
        <property type="entry name" value="PTHR46584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="SSF47095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="180"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="180"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX86576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="411" mass="45167" checksum="13DAC6DAC941BFB1" modified="2011-04-05" version="1">MAAAKGKPKKSVEPARSALTVPPLQIRIPKNVNPPPIALKAETYEDDASTDGDSDEFSNSMDKEELETYHDDSNSQLDDYEQDDSLMKHGDKMKHQGNNSNFMKGMAEMEEDDSDDHIDPETNSDSEADVDVAGPSDPPNFMGNTKQPSLYLLENAKKKIVLKDGKLVAARQKAQRKDKGKTRFTAYMLWSKEMRPVVSRQNPDLKFEQVSKRLGELWATVSQAERMTWKRRAMRQGTKSSGGMISTGVKPQPVSRVKPTVSPKRVFADLCCKHFLLLGARGTVKPLSPAKQRQRFTSSDGFDNVTIAENDSSTLGSPPSVVQPRAHELEPLDVATHLHLLGESLSVIGSRLKEQNGQIAVSGSLSVLLDSVVCALGPLLCLTRLTPETNGCPPETLSRILDNIAYIMPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9G287</accession>
    <name>E9G287_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_222205</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="EMBL" id="EFX85797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="128" mass="14622" checksum="BBC5BD645B12DB2E" modified="2011-04-05" version="1">MRRSGAGAPCGLLQIPAFRFHRFAWPFETAGPSVDIAGKRRVGKDKSNTPPPPSRPHEKWDEPRSAGAKRFPSLILGFRHQRWLSAAPIEVSRCTQEKVAADRSFDFRKRDDVQDKVQDYKENRSITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9G5J0</accession>
    <name>E9G5J0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_237667</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85624">
        <property type="protein sequence ID" value="EFX85624"/>
        <property type="gene ID" value="DAPPUDRAFT_237667"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_237667"/>
    <dbReference type="HOGENOM" id="CLU_761328_0_0_1"/>
    <dbReference type="OrthoDB" id="1796085at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240042" evidence="2">
        <location>
            <begin position="19"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX85624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="364" mass="39231" checksum="E41482E4858AA6A7" modified="2011-04-05" version="1">MKLLAIVIIACSVSICQAYPHDHDDQHDQDDYDFIDLIASIAAAIILDDVSDEIENLSPSELLDNVTGLIDMASLKANTLLSIDSLTAEQHVLGLASLESCVESNFTLPDPPPFVAAANATVDQLFHNLGKYDIRNNPMRIMGCFSDSISNKLVTAPESDKSLDENSPRDGNGDEIVSGVSKAKPIDFALEGGSTRKKANESMGIILIVLGSCGLPSVLFFAAMKAHPHPEKRSASLEGSFMSAVPISLTDDMPPEIESPDFPQLMVDEMTSQLDMAGYGKYYETTSLSSEQQALATADFNSCVTANLITPSLPVFVRWTLSSNEVIGNLVTANHGCSDTSVSNSTLTWIMQNLQARIAKEILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9G5N3</accession>
    <name>E9G5N3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_193775</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="3"/>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85598"/>
    <dbReference type="EnsemblMetazoa" id="EFX85598">
        <property type="protein sequence ID" value="EFX85598"/>
        <property type="gene ID" value="DAPPUDRAFT_193775"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_193775"/>
    <dbReference type="eggNOG" id="KOG1500">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017375_0_1_1"/>
    <dbReference type="InParanoid" id="E9G5N3"/>
    <dbReference type="OMA" id="PTQCYQF"/>
    <dbReference type="OrthoDB" id="840669at2759"/>
    <dbReference type="PhylomeDB" id="E9G5N3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035247">
        <property type="term" value="P:peptidyl-arginine omega-N-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PTHR11006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="8">
        <location>
            <begin position="164"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX85598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="608" mass="67332" checksum="0E93E95DA7AE8B3E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6A4</accession>
    <name>E9G6A4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_1878</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX85024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX85024">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Wolf Y.I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Tsuchiya D."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="291" mass="32647" checksum="1E29B27B2ACD8D7D" modified="2011-04-05" version="1">MKFNLQTGRPVCMSLTLEGREEVYTHPQQHQPNEGKPSLHFLHFRRSRRSLRKTCHVTAERLGENDTCNIIIKQFQKPQGFRVIYGVVLLLGVESLMIGSTTGVLMSPGPHNIAVLLLNINAVPAYTTKAPMYYTTKALDKLWRRIKYYTNEASKYYTTIYAASRCITKEPEPIPGNVNLQMGRPLRAVLLFGVVSLMVGSTTGVPMSPGYGGYQATAAKEYYTTSPPYYNTTTATPPRLKSYATNYAAPSCITKAPEYYITEAPKYYTTEYSVPAYYTAVPKYYTTTNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBF9</accession>
    <name>E9GBF9_DAPPU</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
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                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="222" mass="24318" checksum="2F025B2ED4C737D3" modified="2011-04-05" version="1">MKLQFPPGSSMFSNSASPSTPARSSSGATTTTGRRKHFTQQQSTTANQLSSTDSEPDIEEAGDRCTRKRRSNKNTSATAAAESAHGTTAQDSNKRPSSKHKKNTRHRDPLTPNNSFSIADGSVVRKRDSQIMSEVTTPGMVRSPAMHEGFRLADWDVVTPSLASAEAVEARNYFTLQHRWMLLHDPSNVLQGERIVFSSQTGSAVHIPDKIVSFKLNCFIVL</sequence>
</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Robertson H.M."/>
                <person name="Bork P."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="138" mass="15162" checksum="316C5AB943818D1A" modified="2011-04-05" version="1" fragment="single">AVKLHPSSCSADLSNVRPSSFSECDCWHLLNRWINICDAKKHEGASTSCVVDVLLRNHPILAELFNQKMKVFLRVVVVAVVIETTSACDCNFQFPRGCYLVRAASPGMACKCVFSLGWTCRLPRSSSGLQGPQSRTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX82345"/>
        <property type="gene ID" value="DAPPUDRAFT_302564"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302564"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="E9GEA5"/>
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    <dbReference type="PhylomeDB" id="E9GEA5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240905" evidence="2">
        <location>
            <begin position="22"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="111"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX82345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="387" mass="42106" checksum="5FD5730CF1846686" modified="2011-04-05" version="1">MAVEKFRSLFLTAFLIAAASGSIAPLKLDTQEVVLNLQPPSFSIKLNLRNDSSLLDLPWTNGKEQEKVPAPTDTTISPIRTSSSRAPSTTPSYWYGDCGVANLMDEATDRIVGGVQAIPNEFPWQAFVKVETNAGNIYYCGGSLIADRWILTSARCVLIPGQTLRYLTIYLGAHDITASYEANRRVYNGYEAYIHPEWNPSTQAGDIALIKLCNIVTYTQYIRPVCLATYNEPSYVNSQVAVAGWGTTSDGSYTLSPVLREVTVPVISNTQCSNYYGSAVVTSKVMCTTGMLSRGPCNGDNGGPLIFRESNGRWKQIGIVSFVSSQGCQSGYPYGYTRLSSYSTWVQNVMSSYSGSPSTTTTPSPSSGSQTFAILSLVISLFLLMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9GF13</accession>
    <name>E9GF13_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinase</fullName>
            <ecNumber evidence="3">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_317135</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="3"/>
    <dbReference type="EMBL" id="GL732541">
        <property type="protein sequence ID" value="EFX81927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81927"/>
    <dbReference type="EnsemblMetazoa" id="EFX81927">
        <property type="protein sequence ID" value="EFX81927"/>
        <property type="gene ID" value="DAPPUDRAFT_317135"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_317135"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014862_0_0_1"/>
    <dbReference type="InParanoid" id="E9GF13"/>
    <dbReference type="OMA" id="YDGPDHG"/>
    <dbReference type="OrthoDB" id="1102768at2759"/>
    <dbReference type="PhylomeDB" id="E9GF13"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="PTHR12400"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX81927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="412" mass="46483" checksum="026C02C34A679F70" modified="2011-04-05" version="1">MQFIIDFLIQAIKKSPLLNLSAKELKTPIPIATSTEPLGKGVVNLEPFVHQVGGHSSMLCLDEATSVGKPLLVREKAFYENLPEILAPFTAQYRGTIQVTCNEDAGGYLTLTTFPPAGYVAHEGTMPVKHRIKWHHGICIDIECVETSSDEDIFEDDTSMTPVSSSPCVEHSIERRPSHSHNPWILHCHRGHIAKMLGLDEESTHSQQSHSQCHFENLPSFEFLLLENLTWRRKRPCVLDVKMGTRQYGDDAPESKRRSQSLKVENSTSGSLGIRLCGMQVFQVTTNKYLCRNKYYGRSLTDDGLRSSLTQFFHNGERLRTDIFLPLLDRLNRLLAVINQLDSYRLFTSSLLIIYDGLDGQPSEIDVRIIDFAHATQRDMTAESQVYTGPDDGFIFGLKSLVDLIEELSKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9GFX6</accession>
    <name>E9GFX6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase NRDP1</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RING finger protein 41</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">RING-type E3 ubiquitin transferase NRDP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DAPPUDRAFT_49933</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="GL732542">
        <property type="protein sequence ID" value="EFX81716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81716"/>
    <dbReference type="EnsemblMetazoa" id="EFX81716">
        <property type="protein sequence ID" value="EFX81716"/>
        <property type="gene ID" value="DAPPUDRAFT_49933"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_49933"/>
    <dbReference type="eggNOG" id="KOG0297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076732_0_0_1"/>
    <dbReference type="InParanoid" id="E9GFX6"/>
    <dbReference type="OMA" id="SRQPTCP"/>
    <dbReference type="OrthoDB" id="918518at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015036">
        <property type="entry name" value="NRDP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037255">
        <property type="entry name" value="NRDP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08941">
        <property type="entry name" value="USP8_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160088">
        <property type="entry name" value="SSF160088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFX81716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="315" mass="35861" checksum="45C2245750F67D30" modified="2011-04-05" version="1">MGIEINRFQGEVDEELLCPICSSVLENPLQAPNCEHAFCSACIHEWLSRQPTCPVDRQNITPPQLRPVPRILRNLLYRLSLTCDNSVYGCTAILKLDALESHVQECEFNPKRPVPCELGCGLVVPKDELKEHNCVRELRSLMQAQQSKLVEVQAEVAEGKFQMSEQKRELQLLKDYMLAMRNANPSLRILADQMEADEVRRWAETLPKARVLRWGGMISTPDTVLQAMIKRALSESGCPPHIIQDLMENAHERRWPTGLSSLEIRQLNRRQYENYVCRRIPGKQAVAVMACDNGHMNPDMILEPGLIMIFAHGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GG14</accession>
    <name>E9GG14_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
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    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX80862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="154" mass="17224" checksum="6517261E768B10F0" modified="2011-04-05" version="1">MGSADGILLVSLGLKNSIHHESVHFWRPHFRRCCWIHSGVRRQTSGHREPIDVRNVDGSSQWSFAGSDGTTREESQIQKQLSSGYDKETALGNTNKGSTYYISPEGQKITLTWISDENGFQPKGDHLPTPPPVPEEIARMLPTLPKLVEPYQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E9GI17</accession>
    <name>E9GI17_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DAPPUDRAFT_196539</name>
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    <organism evidence="18">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732545">
        <property type="protein sequence ID" value="EFX80954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="6669.EFX80954"/>
    <dbReference type="EnsemblMetazoa" id="EFX80954">
        <property type="protein sequence ID" value="EFX80954"/>
        <property type="gene ID" value="DAPPUDRAFT_196539"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_196539"/>
    <dbReference type="eggNOG" id="KOG1226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011772_1_1_1"/>
    <dbReference type="InParanoid" id="E9GI17"/>
    <dbReference type="OMA" id="NCVCGAC"/>
    <dbReference type="OrthoDB" id="473040at2759"/>
    <dbReference type="PhylomeDB" id="E9GI17"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cell adhesion mediated by integrin"/>
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        <property type="term" value="P:cell migration"/>
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    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
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    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
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        <property type="entry name" value="Integrin_beta_N"/>
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        <property type="entry name" value="Integrin_bsu"/>
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        <property type="entry name" value="Integrin_bsu_cyt_dom"/>
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        <property type="entry name" value="Integrin_bsu_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036349">
        <property type="entry name" value="Integrin_bsu_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="PTHR10082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08725">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07965">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17205">
        <property type="entry name" value="PSI_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002512">
        <property type="entry name" value="Integrin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01241">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Integrin_B_tail"/>
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    </dbReference>
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        <property type="entry name" value="INTEGRIN_BETA"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237061" description="Integrin beta" evidence="13">
        <location>
            <begin position="21"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="742"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="INB" evidence="14">
        <location>
            <begin position="43"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin_B_tail" evidence="16">
        <location>
            <begin position="662"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin_b_cyt" evidence="15">
        <location>
            <begin position="768"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="44"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
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    </feature>
    <feature type="disulfide bond" evidence="10">
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    <feature type="disulfide bond" evidence="10">
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    <feature type="disulfide bond" evidence="10">
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    <feature type="disulfide bond" evidence="10">
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    <feature type="disulfide bond" evidence="10">
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    <feature type="disulfide bond" evidence="10">
        <location>
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    <feature type="disulfide bond" evidence="10">
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    <feature type="disulfide bond" evidence="10">
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    <feature type="disulfide bond" evidence="10">
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    <feature type="disulfide bond" evidence="10">
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    <feature type="disulfide bond" evidence="10">
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    <feature type="disulfide bond" evidence="10">
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    <feature type="disulfide bond" evidence="10">
        <location>
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    <feature type="disulfide bond" evidence="10">
        <location>
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    <feature type="disulfide bond" evidence="10">
        <location>
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    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
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        </location>
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    <feature type="disulfide bond" evidence="10">
        <location>
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    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01241"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01242"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFX80954.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="815" mass="89751" checksum="49D6DB3FCEFFF52A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9GI24</accession>
    <name>E9GI24_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_303775</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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        <property type="protein sequence ID" value="EFX78726"/>
        <property type="gene ID" value="DAPPUDRAFT_245871"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_245871"/>
    <dbReference type="HOGENOM" id="CLU_1742415_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX78726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="150" mass="17271" checksum="B592F363CBFF26AB" modified="2011-04-05" version="1">MDVELDVELDVELNVELGVELDEEGEDYLTCASTPHPHRDKRLLLSLLLLRAERRFLRRHRELVDERISIKSLKCFNNDLVAKLKCKVQNAPMAKKSERHRILYNHQVKLLNDNSAEMRAKATKPSRTEMTSRTCLHCKKTTSTSSGEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQ18</accession>
    <name>E9GQ18_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_35703</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732557">
        <property type="protein sequence ID" value="EFX78492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78492">
        <property type="protein sequence ID" value="EFX78492"/>
        <property type="gene ID" value="DAPPUDRAFT_35703"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_35703"/>
    <dbReference type="HOGENOM" id="CLU_2313091_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GQ18"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX78492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="100" mass="10250" checksum="E99CC072284FAA17" modified="2011-04-05" version="1" fragment="single">PGTASNPVTSEILAVIAKHSPQVDQPMPLASTSQVETPTPTASTSQVRTPKATPKRTAASKSKASTPKEVNVEALKTPALLSPISPKPSKGKAVARSKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQC4</accession>
    <name>E9GQC4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_246381</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732558">
        <property type="protein sequence ID" value="EFX78369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78369">
        <property type="protein sequence ID" value="EFX78369"/>
        <property type="gene ID" value="DAPPUDRAFT_246381"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_246381"/>
    <dbReference type="HOGENOM" id="CLU_1742416_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX78369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="150" mass="17115" checksum="9B6A12DF762D1892" modified="2011-04-05" version="1">MVEYLAFKIPDGEESRIDPARQQHSQVSFLKDGSTLLHWCLSGCVNGEAEGQNNNLLEVFAPHRRTGWNWNTRLIPMQRQQHISVASYKTNKEAEPMKFSPITRCDCDRNCSTAYGFDFRLTGGITSCMSRPTYFTRSVNLLPHKLTSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQY9</accession>
    <name>E9GQY9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein SA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_320706</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with ribosomal protein S21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX78249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78249"/>
    <dbReference type="EnsemblMetazoa" id="EFX78249">
        <property type="protein sequence ID" value="EFX78249"/>
        <property type="gene ID" value="DAPPUDRAFT_320706"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_320706"/>
    <dbReference type="eggNOG" id="KOG0830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058171_1_0_1"/>
    <dbReference type="InParanoid" id="E9GQY9"/>
    <dbReference type="OMA" id="ENKMKRY"/>
    <dbReference type="OrthoDB" id="1129610at2759"/>
    <dbReference type="PhylomeDB" id="E9GQY9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="40S_SA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_S2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_S2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="PTHR11489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="40S_SA_C" evidence="8">
        <location>
            <begin position="202"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX78249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="301" mass="32909" checksum="E21879A0539FA370" modified="2011-04-05" version="1">MSGGSDKLSLKEDDVTKMLAATTHIGSTNVDFQMEQYVYKRRSDGVHIINLRRTYEKLLLAARAIVAIENSADVFVVSSRPQGQRAALKFASYTKATPIAGRFTPGAFTNQIQAAFREPRLLVIMDPRADHQPIVEASYVNIPVIALCNTDSPLRYVDIAIPCNNKASHSIGLMFYMLAREVLRLRGIISRDLEWSIMADMFFYRDPEDIEKEEQAKEAAAIAAAPIKAAPEEYQAENWNTEPAVESTNWADEAPVPAAAAPTVYAAAAEDWASAPTDDWGAPVAAASATGEWGGATNNWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9GS06</accession>
    <name>E9GS06_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pinin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DAPPUDRAFT_225597</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="20">Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Desmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pinin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732561">
        <property type="protein sequence ID" value="EFX77618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77618"/>
    <dbReference type="EnsemblMetazoa" id="EFX77618">
        <property type="protein sequence ID" value="EFX77618"/>
        <property type="gene ID" value="DAPPUDRAFT_225597"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_225597"/>
    <dbReference type="eggNOG" id="KOG3756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051083_0_0_1"/>
    <dbReference type="InParanoid" id="E9GS06"/>
    <dbReference type="OMA" id="RDFKAWE"/>
    <dbReference type="OrthoDB" id="1482883at2759"/>
    <dbReference type="PhylomeDB" id="E9GS06"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006787">
        <property type="entry name" value="Pinin_SDK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PTHR12707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04697">
        <property type="entry name" value="Pinin_SDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Pinin_SDK_N" evidence="23">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Pinin_SDK_memA" evidence="22">
        <location>
            <begin position="152"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="25"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="340"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00025916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EFX77618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="371" mass="43641" checksum="E79AD53563E98185" modified="2011-04-05" version="1">MAVAVENFQAELEKARETLNKVDENIKKITGRDPTEARNARFQSQVGNNEGRENAQARNRIPPRFQGRLSSRDEQEKRHDGPTHTKRIVREGNDGRPTPLVAIGNPKGWRNDDYEEGELPRKGAIHSSITAPNADRKTREEALAQQSKDVKVKDRNRRMFGSLLGTLAKFRMEESSQKDKEEKRARIEQRLEETARQEKESLRKERNELFMERKRQQAHVRRLEWKMHRLREHDEWATRQQPLMKFIKLTTTPPLYYKPKVWTPKTEELLKESQRKLKEMLETRRKELEEELLRVEEKAIARLERVRERGYRVAPASEQDAELEELEAEIEMYALALGEEKEEDMELHPEKVSQGPLTFPKHDPDEPMDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GSU6</accession>
    <name>E9GSU6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_247629</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732562">
        <property type="protein sequence ID" value="EFX77520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77520">
        <property type="protein sequence ID" value="EFX77520"/>
        <property type="gene ID" value="DAPPUDRAFT_247629"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_247629"/>
    <dbReference type="HOGENOM" id="CLU_2457059_0_0_1"/>
    <dbReference type="OrthoDB" id="1874043at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="89" mass="10277" checksum="2A7E8D3843A89254" modified="2011-04-05" version="1">MAWPPPMNIAEPANDDPEVSPAKWIGSIQVPTPHPIFELIQRSSDFIKIKRIVAWQLRFLRNHSLSLKKCVIPYLDGSQLRNCVMPKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTD4</accession>
    <name>E9GTD4_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_247789</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732563">
        <property type="protein sequence ID" value="EFX77259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77259">
        <property type="protein sequence ID" value="EFX77259"/>
        <property type="gene ID" value="DAPPUDRAFT_247789"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_247789"/>
    <dbReference type="HOGENOM" id="CLU_1031586_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX77259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="270" mass="30267" checksum="76F32C2934FA1672" modified="2011-04-05" version="1">MEDERDGRQFRVIAPRRILSTCDLPSSREPYHVETAVLISRVLAVLEAGASAGVTWNFYFGILLTMKLKLSKSTKPALVPKPWRQILGLPDGYMEALQVRDNRYRIVYKMISGNVKVLRSLTDVQAHLRQHPDPRVDFSKFNFLEKYFQATTLHEALALEGKAADTAEPLVDDSLAKDVVQESIPDLLCGWGSIFKEGDRISENHYLNLGRKMEIDVSNSDVGKNAASEAASTNTITATHETIAATQAKFENWFNGRDSYSQSLIGKTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GV75</accession>
    <name>E9GV75_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_225993</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732567">
        <property type="protein sequence ID" value="EFX76614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76614">
        <property type="protein sequence ID" value="EFX76614"/>
        <property type="gene ID" value="DAPPUDRAFT_225993"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_225993"/>
    <dbReference type="HOGENOM" id="CLU_1316606_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="209" mass="22890" checksum="9EABBE41A381522A" modified="2011-04-05" version="1">MLSNGSRLGCKGSHSSRNNKILIIKSMPAYFSAPTTPSDKSDNEPTFESVRTGQVNPSKDPSKQRQQHQQQRRNSGCATSTPSNNVRQQYMATPSLSQSGTTASTRGLAITVNRSRLVQELLEQNSAMLLKLKDRPEVMTTSEPSSAVPIGDASEPVVHEWNQQQQQPGSLVNNKGASPIHHNPFPRNLVRPPKDVAVKLGLYSSSQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GVN8</accession>
    <name>E9GVN8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_322354</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732568">
        <property type="protein sequence ID" value="EFX76497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76497">
        <property type="protein sequence ID" value="EFX76497"/>
        <property type="gene ID" value="DAPPUDRAFT_322354"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_322354"/>
    <dbReference type="HOGENOM" id="CLU_3034500_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX76497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="55" mass="5799" checksum="77C2339E195FC0CE" modified="2011-04-05" version="1">MGPNVNLSQVESQRLFPLSQEATSIGSWIPGMQMTLGLQNSQGGLPPASNATQPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GW00</accession>
    <name>E9GW00_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_249156</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732569">
        <property type="protein sequence ID" value="EFX76359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76359">
        <property type="protein sequence ID" value="EFX76359"/>
        <property type="gene ID" value="DAPPUDRAFT_249156"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_249156"/>
    <dbReference type="HOGENOM" id="CLU_1961809_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX76359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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    <accession>E9GW57</accession>
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        </submittedName>
    </protein>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX76289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_249216"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_249216"/>
    <dbReference type="HOGENOM" id="CLU_191702_0_0_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="69" mass="7361" checksum="034F4B8A0A16520D" modified="2011-04-05" version="1">MVEALWLLPVMQKRRREDGHQNIAVNPLSATPLSSPSSLARAACAVRSRGFHAAGRKVAPAQNLPQGAC</sequence>
</entry>
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    <reference evidence="1 2" key="1">
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Ye Y."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76087">
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        <property type="gene ID" value="DAPPUDRAFT_322569"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_322569"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="51" mass="6028" checksum="61F101BAF8C6A3DB" modified="2011-04-05" version="1">MVCTEEQLITIDSFATKNPLVNERYDIRKRETDLLELCDLDREMLKELGLI</sequence>
</entry>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX76132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX76132"/>
        <property type="gene ID" value="DAPPUDRAFT_306297"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306297"/>
    <dbReference type="HOGENOM" id="CLU_2576272_0_0_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX76132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="81" mass="9226" checksum="6075A5A02C847EA2" modified="2011-04-05" version="1">MPSISQEGNGKLVNQVIIDCLHSFLTYPLHADVMFEGKFFKTRYPVYATSCFICMSCLRESVRIANYAIYQSRGQLPLLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GX85</accession>
    <name>E9GX85_DAPPU</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
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                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732572">
        <property type="protein sequence ID" value="EFX75826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75826">
        <property type="protein sequence ID" value="EFX75826"/>
        <property type="gene ID" value="DAPPUDRAFT_249745"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_249745"/>
    <dbReference type="HOGENOM" id="CLU_1526742_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="176" mass="20268" checksum="3850C12FC8701FBD" modified="2011-04-05" version="1">MKTTANPMEPHPCPIGIASVRPNFSRKKKMDRTRKLGKLIPESLKTVISYWKSYGESKFHEPEISQKSGKSKIMKFKTTWKLSKVTGKIMELLSSASQSYRKNRENLIVYESLSNEEPTLAPIPPAPKPAEPPRQGRSRGRGVLMYTKESLRESPRERSVSRIRWVRRLAEQQEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYB1</accession>
    <name>E9GYB1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_11606</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732574">
        <property type="protein sequence ID" value="EFX75571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75571"/>
    <dbReference type="EnsemblMetazoa" id="EFX75571">
        <property type="protein sequence ID" value="EFX75571"/>
        <property type="gene ID" value="DAPPUDRAFT_11606"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_11606"/>
    <dbReference type="eggNOG" id="KOG1043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008958_2_1_1"/>
    <dbReference type="InParanoid" id="E9GYB1"/>
    <dbReference type="OMA" id="LRFQLNM"/>
    <dbReference type="OrthoDB" id="516860at2759"/>
    <dbReference type="PhylomeDB" id="E9GYB1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006875">
        <property type="term" value="P:cellular metal ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011685">
        <property type="entry name" value="LETM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="PTHR14009"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="9">
        <location>
            <begin position="101"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX75571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="546" mass="61973" checksum="BD4CF359FF6DC569" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZJ1</accession>
    <name>E9GZJ1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alkylated DNA repair protein alkB homolog 8</fullName>
            <ecNumber evidence="6">2.1.1.229</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Probable alpha-ketoglutarate-dependent dioxygenase ABH8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DAPPUDRAFT_306906</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>carboxymethyluridine(34) in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:10408"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74851"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.1.1.229"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.229" evidence="6"/>
    <dbReference type="EMBL" id="GL732578">
        <property type="protein sequence ID" value="EFX75001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75001"/>
    <dbReference type="EnsemblMetazoa" id="EFX75001">
        <property type="protein sequence ID" value="EFX75001"/>
        <property type="gene ID" value="DAPPUDRAFT_306906"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306906"/>
    <dbReference type="eggNOG" id="KOG1331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029501_4_0_1"/>
    <dbReference type="InParanoid" id="E9GZJ1"/>
    <dbReference type="OMA" id="PWKTKDE"/>
    <dbReference type="OrthoDB" id="996085at2759"/>
    <dbReference type="PhylomeDB" id="E9GZJ1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12431">
        <property type="entry name" value="RRM_ALKBH8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034256">
        <property type="entry name" value="ALKBH8_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="18">
        <location>
            <begin position="185"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFX75001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="574" mass="65358" checksum="FE8CEA99032FEC03" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9H057</accession>
    <name>E9H057_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRP15-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_93055</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732579">
        <property type="protein sequence ID" value="EFX74940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74940"/>
    <dbReference type="EnsemblMetazoa" id="EFX74940">
        <property type="protein sequence ID" value="EFX74940"/>
        <property type="gene ID" value="DAPPUDRAFT_93055"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_93055"/>
    <dbReference type="eggNOG" id="KOG2974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079732_1_1_1"/>
    <dbReference type="InParanoid" id="E9H057"/>
    <dbReference type="OMA" id="ARDYNSE"/>
    <dbReference type="OrthoDB" id="1522334at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="PTHR13245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX74940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="266" mass="30256" checksum="C4B92C68051544E0" modified="2011-04-05" version="1">MDFSNDEDLRSDEEHDDLNSGLEASLSDDGDSYTKGSSDSDSEANENVDGNQEDQNVVYGNFGWADAMSKVLKSSKPKAKKSIILSKAKKDADILKIISAQEISSVSFEIDEVKKEKIVEDPDVVRRNAHLEKMLRRQRRKEWDLVGRVLPSITDERERERVLSKIATRGVVQLFNSVKIQQKTIQDKLREAGPLERKREKALKSLNKADFLELLKGGKHGKGEVKMEHSTKQEEATWSVLRDDFMPEVTMRDWDKQNSSDSEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0W4</accession>
    <name>E9H0W4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1</fullName>
            <ecNumber evidence="1">2.1.1.57</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cap1 2'O-ribose methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_307206</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67020"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="Rhea" id="RHEA-COMP:17168"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167609"/>
            <dbReference type="EC" id="2.1.1.57"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="1"/>
    <dbReference type="EMBL" id="GL732582">
        <property type="protein sequence ID" value="EFX74631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74631"/>
    <dbReference type="EnsemblMetazoa" id="EFX74631">
        <property type="protein sequence ID" value="EFX74631"/>
        <property type="gene ID" value="DAPPUDRAFT_307206"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307206"/>
    <dbReference type="eggNOG" id="KOG3673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011097_0_0_1"/>
    <dbReference type="InParanoid" id="E9H0W4"/>
    <dbReference type="OMA" id="GGILMFC"/>
    <dbReference type="OrthoDB" id="1336442at2759"/>
    <dbReference type="PhylomeDB" id="E9H0W4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:mRNA (nucleoside-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097309">
        <property type="term" value="P:cap1 mRNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030376">
        <property type="entry name" value="Cap_mRNA_MeTrfase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025816">
        <property type="entry name" value="RrmJ-type_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF0">
        <property type="entry name" value="PTHR16121:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51613">
        <property type="entry name" value="SAM_MT_RRMJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="RrmJ-type SAM-dependent 2'-O-MTase" evidence="4">
        <location>
            <begin position="134"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX74631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="742" mass="85449" checksum="9E06AE10D4E8EE43" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9H1G8</accession>
    <name>E9H1G8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
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        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
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            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
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    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
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                <person name="Manak J.R."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="EnsemblMetazoa" id="EFX72640">
        <property type="protein sequence ID" value="EFX72640"/>
        <property type="gene ID" value="DAPPUDRAFT_110480"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_110480"/>
    <dbReference type="eggNOG" id="KOG4257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055889_0_0_1"/>
    <dbReference type="InParanoid" id="E9H6E0"/>
    <dbReference type="OrthoDB" id="43729at2759"/>
    <dbReference type="PhylomeDB" id="E9H6E0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0007172">
        <property type="term" value="P:signal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036137">
        <property type="entry name" value="Focal_adhe_kin_target_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68993">
        <property type="entry name" value="SSF68993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX72640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="410" mass="45530" checksum="8189FBCDFD85C40A" modified="2011-04-05" version="1">MSLSRKPTMMHCSLKNCSSALFALFPVSLNHGRVISLVESIKAIRIIRCYIVACWPMSNTKRTQSRIESGYFLLKCWSNEPSKRPCFREIQETLCEILMEERREGDETMSRENRRVAVISWSSTGSAGHGVDLPPPKPSRVPATYVGIGGSAGKSLPSASSLSVPSGPTTYLVAPNSEVLAQLIRDNETRADAGHYTSPALAFNRFTVDFSHTSSSNSNPASSQHKSKTKGRKKQPVDANIMMDDATPPSAEIAAAAVATNPAPYKEVRISACQFEQQRTKRTISRPTYGARTEDWKLRQQQRQSEEDSRWLGEEESHMRKKLSVAASLSDRSDTDSMDGANAYQKYRSTPLQGNQLDDRSVVVKKLEPTPTARLDRTHDKVYDATTSFRAVMLLSQGVRQPKLKITLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6K6</accession>
    <name>E9H6K6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tubulin-specific chaperone D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_254221</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCD family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732597">
        <property type="protein sequence ID" value="EFX72684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72684"/>
    <dbReference type="EnsemblMetazoa" id="EFX72684">
        <property type="protein sequence ID" value="EFX72684"/>
        <property type="gene ID" value="DAPPUDRAFT_254221"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_254221"/>
    <dbReference type="eggNOG" id="KOG1943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_400761_0_0_1"/>
    <dbReference type="InParanoid" id="E9H6K6"/>
    <dbReference type="OrthoDB" id="79003at2759"/>
    <dbReference type="PhylomeDB" id="E9H6K6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034333">
        <property type="term" value="P:adherens junction assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="Tubulin_specific_chaperoneD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="PTHR12658"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFCD_C" evidence="4">
        <location>
            <begin position="163"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="266"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX72684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="687" mass="77116" checksum="0FEBD3AC45C58386" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9H7Y8</accession>
    <name>E9H7Y8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfotransfer_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_201267</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732602">
        <property type="protein sequence ID" value="EFX72112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72112">
        <property type="protein sequence ID" value="EFX72112"/>
        <property type="gene ID" value="DAPPUDRAFT_201267"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_201267"/>
    <dbReference type="eggNOG" id="KOG1584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027239_1_1_1"/>
    <dbReference type="InParanoid" id="E9H7Y8"/>
    <dbReference type="OMA" id="HEPWLYY"/>
    <dbReference type="OrthoDB" id="780670at2759"/>
    <dbReference type="PhylomeDB" id="E9H7Y8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051923">
        <property type="term" value="P:sulfation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransfer_1" evidence="1">
        <location>
            <begin position="49"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX72112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="311" mass="36021" checksum="F5D3DA80E670467C" modified="2011-04-05" version="1">MPESLEEQFLKDFPSYDVEGLVRGEPGGFVLTPQYGEHAEELYNFHVRPDDIWVLSFPKSGTTWTQELVWLIANDCDFEGAKKKLNDRSPFIEKGENHYAHLPSIEKQLELVGNLASPRIIKTHLPLDLLPPQLSETCKVVYVARNPKDVIVSYYFHHQLIKFHYFDGDLQSFAHRFMQDQVFYSPYFGQILSAWERAKTDENVLFLFYEDLKKDLRGGIERVARFLGKSLSEDQLAKLTQHLTFENLSKNSAVNKEEGKTSGSFNENGQFMRKGETGDWEKHFSPELSRQIDEWTESNLRGSDITFVDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9H8G4</accession>
    <name>E9H8G4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_111184</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732604">
        <property type="protein sequence ID" value="EFX71984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71984">
        <property type="protein sequence ID" value="EFX71984"/>
        <property type="gene ID" value="DAPPUDRAFT_111184"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_111184"/>
    <dbReference type="HOGENOM" id="CLU_589594_0_0_1"/>
    <dbReference type="OrthoDB" id="1770304at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="464" mass="52234" checksum="3CD29309A58EE87C" modified="2011-04-05" version="1">MFDASPSQPQPSPSDDDAYAQPIQSRNSRDSSSDPSKEYLPQKHNREDDDGMGDEEASDEKDLDWSSGMMKTSRVKLLPSMSQVLRRQENTMRHLKLLDQKMEGIKRKLTGVHNAGPSESEYVARLLSKLPLNSADEMTEFLEEINDAIADKSITIGYLKTHDKYILKAVVSLELARKLTYFGVKPKDGDGDRLAFSTTYICNELLEKSVRENFPNSELDEKFFQKHISNWLNGTSNVSDCDRENVNAVFVDFVNTSCCEVDNEQDYGKSDDSGENEDDLGENEDDELSEMESSFEDCGEFTEEEESLENRVAAIAIKHRLSGAVVRSITNLLINLGNKIYKDRRTILKTPRTKLGSTSFKHFGLIEGLDRKLKSGLLICSAGAELQISIDGLPLCKSRPTVFWPILCRVKNANDSSPFPVSIHCGNGRKRPDLNLYLEPLIEELKHIEINGIKIMGKLYCCNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9H8L8</accession>
    <name>E9H8L8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_308640</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732605">
        <property type="protein sequence ID" value="EFX71840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71840"/>
    <dbReference type="EnsemblMetazoa" id="EFX71840">
        <property type="protein sequence ID" value="EFX71840"/>
        <property type="gene ID" value="DAPPUDRAFT_308640"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_308640"/>
    <dbReference type="eggNOG" id="KOG3333">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108540_0_0_1"/>
    <dbReference type="InParanoid" id="E9H8L8"/>
    <dbReference type="OMA" id="TSEWAIK"/>
    <dbReference type="OrthoDB" id="1336080at2759"/>
    <dbReference type="PhylomeDB" id="E9H8L8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX71840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="191" mass="22026" checksum="DC841F340AC908B1" modified="2011-04-05" version="1">MLEARIRNASLFSLIKRTYSSGNEALLEGPNNSFLPFIYNRNPRNLERLRIAPKPSGYVLDKKPVNYWHRLVIEQSNKHWNAYIEHFEGSRVVTASTKEWAIKQFLRSTSDSVAAAIVGKVLAQRCLEFGLLEVNSDYDLKQTSPKITLVLRNIEEGGIALKEPEQFLPHRHWSREAKEDPTKVYEETQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9HC42</accession>
    <name>E9HC42_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_112453</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732618">
        <property type="protein sequence ID" value="EFX70701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70701">
        <property type="protein sequence ID" value="EFX70701"/>
        <property type="gene ID" value="DAPPUDRAFT_112453"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_112453"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000680_39_4_1"/>
    <dbReference type="InParanoid" id="E9HC42"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="PhylomeDB" id="E9HC42"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="165"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX70701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="377" mass="42381" checksum="EFDE485508D5D460" modified="2011-04-05" version="1">MLRQYSREELMSFNRPAPPSIPQSRFIRLRLSGLCLFRPTKRPKKRRHRTDQKQYQPSLTAKLCLLNARSIVNKIEALNELVSDARPDILAITETWLTPTNGDHELAACCPSGFSAVHQPRASRRGGGVAVIFKSTISVRRHSHPTFNSFKLIDCSLSLRPIAIRLLVVYRPPASSHSVFRDEFSSLLEQIALTNEKLLIVGDFNLSIRDQPDDAAQRLLDSTEAFGLSQLVTSATHEGGSILDLVFTRSSDDLVRGTSVLGFFSDHRSVLVSLSCRSPRFPSMPISFRRLRDIDPEAFVHDIERLNLITDPSDALDCLVAQYNDGLRSLIDKHAPVVTKNVVLRPSAPWITEATRQTKREASRREDLAETKTHRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HEU5</accession>
    <name>E9HEU5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_258148</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Caceres C.E."/>
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                <person name="Dong Q."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Koonin E.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
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    <comment type="similarity">
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="OrthoDB" id="1739788at2759"/>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX69051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="268" mass="30453" checksum="4FC321DCDD3CA4D9" modified="2011-04-05" version="1">MDPGSPLLFRQPNKPGGPRKRPFSVANTGFLSDYSNENSDDYNILSALGMKDRDIFQSPESTNLLMKRENETLENFKVSSSGSVAGGQSPYFNVTNTPTKKSAIQDTQVVKPLNAESPEADATPSNAVTQKEQMLKVQPTASIPIMNNENNVEENKPRKLRPIGEYTVSSLDKEFQDIMDHLKQERERDKQLFLQCSKALREKTESIIENLENIIKGRYQSLDENLHSVIQEFVKEWESGRKLEEEFNVLRNHMSSIMNNILQDPCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HH75</accession>
    <name>E9HH75_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_114156</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732646">
        <property type="protein sequence ID" value="EFX68892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_114156"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_114156"/>
    <dbReference type="HOGENOM" id="CLU_1344471_0_0_1"/>
    <dbReference type="OrthoDB" id="804087at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="204" mass="22918" checksum="AEA717035FD5D9E5" modified="2011-04-05" version="1">MGSGDVAFIASRHQTNRLHPRLHRLKGRSRRFDAVGLEQQQQQLSASVDPLPSKGQFRGSLRRPNEKSQSANFPTARVNSKTTMLLARWESQDLGRDYEEPALGYSPIVVVAKDFGTTYLGYAFSFIHDPEEIHMMHKWEADKQLMHKAAYEACLGSDRLPQQQVNAIYMVVDCGGGTVDITVHQVMDLDGKHLKEFHRATGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9HHX4</accession>
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        <recommendedName>
            <fullName evidence="1">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_259813</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732651">
        <property type="protein sequence ID" value="EFX68663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68663"/>
    <dbReference type="EnsemblMetazoa" id="EFX68663">
        <property type="protein sequence ID" value="EFX68663"/>
        <property type="gene ID" value="DAPPUDRAFT_259813"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_259813"/>
    <dbReference type="eggNOG" id="KOG0873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047036_1_1_1"/>
    <dbReference type="InParanoid" id="E9HHX4"/>
    <dbReference type="OMA" id="EIMFYYA"/>
    <dbReference type="OrthoDB" id="1493916at2759"/>
    <dbReference type="PhylomeDB" id="E9HHX4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000254">
        <property type="term" value="F:C-4 methylsterol oxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="1">
        <location>
            <begin position="81"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="233" mass="27643" checksum="5102BD0F0791AFAE" modified="2011-04-05" version="1">MELKQPPGRWPKWILKYKIQPGTNEPVDFQKVIQTAKVVLINQWFLTVPLLHINYYVKKMNHTMPDFSELPTLQRLFFDLTVFLVIDEIGLYYVHRLQHHPKLYAAVHKKHHEWNAPIAIVFTYSTQMEYLMTLLPVNIGPHIMNPHIVTLCIWYALVHLRGIKNHSGYHFPWFMWPSAHAHDFHHMTSNSCFGKSLVLDRLHGTDKAFHVYMARKKETEEQERLTQISNKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9HI37</accession>
    <name>E9HI37_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NTPase_I-T domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_62984</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRRC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732652">
        <property type="protein sequence ID" value="EFX68607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68607"/>
    <dbReference type="EnsemblMetazoa" id="EFX68607">
        <property type="protein sequence ID" value="EFX68607"/>
        <property type="gene ID" value="DAPPUDRAFT_62984"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_62984"/>
    <dbReference type="eggNOG" id="ENOG502QUZV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041959_0_0_1"/>
    <dbReference type="InParanoid" id="E9HI37"/>
    <dbReference type="OMA" id="VTRTDWH"/>
    <dbReference type="OrthoDB" id="930508at2759"/>
    <dbReference type="PhylomeDB" id="E9HI37"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034199">
        <property type="term" value="P:activation of protein kinase A activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026533">
        <property type="entry name" value="NTPase/PRRC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026534">
        <property type="entry name" value="PRRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23276">
        <property type="entry name" value="PTHR23276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01931">
        <property type="entry name" value="NTPase_I-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTPase_I-T" evidence="4">
        <location>
            <begin position="89"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX68607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="264" mass="28211" checksum="C3A0B3372B5E5183" modified="2011-04-05" version="1">MAASTSALEICVLESPTAANVRDILDPLNDLSNKGSGLFGWMKEAMPGKSILAKVAEKARSSVDTMITTLDPQMKEFIYSGGDIDIAVASSKELKVSSVREAFQTVFGKATVKGYESQSASVAAQPVGFASALQAARERIANLRTGGSILPQQPVVAVEGFVVELFTENWFEMNCLLLEDPVRNVCVQAFSQPLMVPANAIARMRSCTTDSYPLSQSGFAVTVGQAVAEEFNVSATEWQVALTGISRRDILLLAAKTLASSYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJ59</accession>
    <name>E9HJ59_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_63336</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="GL732660">
        <property type="protein sequence ID" value="EFX68225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68225"/>
    <dbReference type="EnsemblMetazoa" id="EFX68225">
        <property type="protein sequence ID" value="EFX68225"/>
        <property type="gene ID" value="DAPPUDRAFT_63336"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_63336"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012949_2_0_1"/>
    <dbReference type="InParanoid" id="E9HJ59"/>
    <dbReference type="OMA" id="MINTHYL"/>
    <dbReference type="OrthoDB" id="508327at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="UDPGT" evidence="6">
        <location>
            <begin position="249"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX68225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="426" mass="49149" checksum="E858BBFDDDC10E0C" modified="2011-04-05" version="1">MQATIERYCRAIYEDPVFHQLMNSKERYDLIILDGFSNDCTLLLAEVFDVPFIYLNCFPPSPWLLYAIGSPLALDHFPNPAGTRDKMDLWQRTFNVVTSVFAVYFHRWLVLPEIDRVASKVLRKNNLTSVAAIENRYLSLILSNTHFSINFQLPTSPAVVEVGGLHLGEARNEIPKDLVSFLDGSGDAGFIIVSFGSMLRGDGLPKDFRRLFLSVFARLPQRIVWKWEDQSKLGESEELIPSNVKTISWLPQKELLSHRNARLFISHGGLLSKQETVFHGVPAIFLPVWADQPINAQKAEDDGYAIRLCWDELTEEILYDAIQAILTNPRYAKRMQQVSALMHDQIDKPMDRAIYWIEYVIRHQGAPHLRNASRDLMLPQRALLDVMCIIFIFTFSMIYVIYRLCLFCSTLYRWKDMMIGLHKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJ94</accession>
    <name>E9HJ94_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_330331</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732660">
        <property type="protein sequence ID" value="EFX68201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68201">
        <property type="protein sequence ID" value="EFX68201"/>
        <property type="gene ID" value="DAPPUDRAFT_330331"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330331"/>
    <dbReference type="HOGENOM" id="CLU_2239251_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="105" mass="11476" checksum="24CDF73B8F9CF069" modified="2011-04-05" version="1">MTGDEVNVASRHQILLPISVEYTEEPEEHVDNQSTTSESMAEDDHLCTAAVVIVVDDPVSHVTTVEPPPLIQTKAATLLDELFYLLSMDGEALFYDSVHSTSSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKH1</accession>
    <name>E9HKH1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_330735</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Zdobnov E.M."/>
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    </evidence>
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        <source>
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    </evidence>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="89" mass="9784" checksum="20CD8F00D13A7BC2" modified="2011-04-05" version="1">MEYAPAYHSIWLRMQPPAFQLPCWDLSASPIPSAVCVYPTQGALMVFVNVAEAILLTVDIFAFHRLGWATSASAMINVVYPKSTHTANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9HQ95</accession>
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        </lineage>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Wolf Y.I."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX66098.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="172" mass="18993" checksum="C77807CA0483818B" modified="2011-04-05" version="1">MIVRSLGIPAVFPSRRGRRGGKSVKINRAAKKFLYCGLVNARSLVSNKYVISHHLTVTGLDVLAVTETWLNEENGDTILREVCSSGYSAIHCPRSRGSGGGVALFFRDSLRVGILSVDFFPDSFEYPYASVCVNGVTLRLVVIYRPPSLSPNQFLTDFADLLELLLPHLQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HRL9</accession>
    <name>E9HRL9_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">DAPPUDRAFT_264451</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX65613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX65613"/>
        <property type="gene ID" value="DAPPUDRAFT_264451"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_264451"/>
    <dbReference type="HOGENOM" id="CLU_1016562_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="274" mass="29780" checksum="87F7368BEEC38427" modified="2011-04-05" version="1">MSSGIQLGRQAGLGGGWIGESAPRLKFGNRLRRSYVRMDSRPTTIHYHMWRKRGETSVLFQTTTRASARYAANVTTTTGQRVTVDLTERIATPSPRGSARAQLTTALEQQRQSKTALITILNTGAASGQAAAGQSGAQALPVTPNISATAVESIPNFESWVKRLPTILRQFCGKSSRGRKFDKCSAYPSSIKKIHEDSFGLAGRVCSSNERLATVTSNSGGLLEKQDVELKELKEDQGKNWGNRPSHVSVNGITHPKETSYLQSASTVEKKDIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9HSP1</accession>
    <name>E9HSP1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine-protein phosphatase domain-containing protein</fullName>
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    <gene>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX65243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_229673"/>
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    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="PhylomeDB" id="E9HSP1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
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    </dbReference>
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        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="203" mass="22433" checksum="E3E29208433C96C9" modified="2011-04-05" version="1">MSKLEAQLRKAKLDPFCICGGITEIERSLPYMIASNVLGVPERQLALGWYPSIILEDTMWLGRMEQGSNTTILLNLNLTHLIHIGQTGPALAFPGMTCLTVNWSESLKGQELYNALKGAASFAIKAAQEKGRILILGDQGVNRSATLTMAVLMQDKNCTLEDAFYYVKCLRPAVQPSPSHLDVLSKFETELFGKKISSVEDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HSQ3</accession>
    <name>E9HSQ3_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_333399</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732755">
        <property type="protein sequence ID" value="EFX65235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65235">
        <property type="protein sequence ID" value="EFX65235"/>
        <property type="gene ID" value="DAPPUDRAFT_333399"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_333399"/>
    <dbReference type="HOGENOM" id="CLU_2760376_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX65235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="70" mass="8262" checksum="4438F03080375E03" modified="2011-04-05" version="1">MVAEQHYADANTLFNELEHWDEVIRLQLEKAGIYEFQLKRLTGVVSKMRNCVYFNPSWIAIVPQKKLCPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9HT72</accession>
    <name>E9HT72_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_65736</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732766">
        <property type="protein sequence ID" value="EFX65039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65039">
        <property type="protein sequence ID" value="EFX65039"/>
        <property type="gene ID" value="DAPPUDRAFT_65736"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_65736"/>
    <dbReference type="eggNOG" id="ENOG502QUC9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041201_1_0_1"/>
    <dbReference type="InParanoid" id="E9HT72"/>
    <dbReference type="OMA" id="FRICPNQ"/>
    <dbReference type="OrthoDB" id="1283095at2759"/>
    <dbReference type="PhylomeDB" id="E9HT72"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
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        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="26"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX65039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="217" mass="23687" checksum="7D70C72074E38D60" modified="2011-04-05" version="1">MQQKSLVYSVFVVLVLAIAPTLVVGHGMMLSPPQRSSMFRFGFKVPPNYNDNGLNCGGFGYNDINKGRCGECGDEWSLPRPRPNDEGGQYGTGIKGKTYYQGSVIDITVNISSNHKGYFEFRLCPKSSASELVTQECLNANLLKMADDTTRFYLPSQESKPYSPRVKLPAGLICENCVLQWLYNAGNSWGVCANGTGALGCGNQETFVNCADISILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HTA2</accession>
    <name>E9HTA2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_117621</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732768">
        <property type="protein sequence ID" value="EFX65020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65020">
        <property type="protein sequence ID" value="EFX65020"/>
        <property type="gene ID" value="DAPPUDRAFT_117621"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_117621"/>
    <dbReference type="HOGENOM" id="CLU_1940207_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="130" mass="14969" checksum="7AE2E1EA9497B89A" modified="2011-04-05" version="1">MRVQLIASQVELEYFSLTFVEYGKQRYRSDTKVIPKGAEECKIGADSESYDELDEPTYVDAVRELPEVNEEASNFDDDEELAETDERNCEDKEDPTSQSEESMKYFDEISEPDLDWAGPEDEADGNKIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E9HTI9</accession>
    <name>E9HTI9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-related modifier 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_304164</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3/UBA4 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3/UBA4 homolog.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732774">
        <property type="protein sequence ID" value="EFX64944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX64944"/>
    <dbReference type="EnsemblMetazoa" id="EFX64944">
        <property type="protein sequence ID" value="EFX64944"/>
        <property type="gene ID" value="DAPPUDRAFT_304164"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304164"/>
    <dbReference type="eggNOG" id="KOG4146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148208_0_1_1"/>
    <dbReference type="InParanoid" id="E9HTI9"/>
    <dbReference type="OMA" id="DYELQPN"/>
    <dbReference type="OrthoDB" id="1541629at2759"/>
    <dbReference type="PhylomeDB" id="E9HTI9"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="PTHR14986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="5">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX64944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="100" mass="11335" checksum="0F62129AD177ED0F" modified="2011-04-05" version="1">MNSELEITLNFSGGAELLFGKIKLHTVKLPSQETWCMKKLLVWIKENLLKERPELFLQGGTVRPGILVLVNNADWELVGQLDYNLQNKDEIVFISTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9HTV6</accession>
    <name>E9HTV6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_265695</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732786">
        <property type="protein sequence ID" value="EFX64823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64823">
        <property type="protein sequence ID" value="EFX64823"/>
        <property type="gene ID" value="DAPPUDRAFT_265695"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_265695"/>
    <dbReference type="HOGENOM" id="CLU_2361845_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003828">
        <property type="entry name" value="QueH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02677">
        <property type="entry name" value="QueH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX64823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="96" mass="10565" checksum="F4420398FE824F87" modified="2011-04-05" version="1">MSRATTAPHQNKMLDSCYDCRLRRTMELTAGLSTDKTTTSALISPIKNRTNSTLNIGDRLVPTRAGNNLQVAFLMKEKLSPTSSSMRNREGPPVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9HV39</accession>
    <name>E9HV39_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_266496</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732837">
        <property type="protein sequence ID" value="EFX64392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64392">
        <property type="protein sequence ID" value="EFX64392"/>
        <property type="gene ID" value="DAPPUDRAFT_266496"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_266496"/>
    <dbReference type="HOGENOM" id="CLU_1662572_0_0_1"/>
    <dbReference type="OrthoDB" id="1806039at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX64392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="159" mass="18832" checksum="4667FFE552C0DAFA" modified="2011-04-05" version="1">MESDSDLDETMLSQIDFDNLEVLDEVGDNDSILELIKEKEDVEKASEGESRKNQEESLDVRKETEETGSVEKDEEVWERTVKFTDDRKVVKNKEGEEKTKEEIELFEKLQACKRKRKEDMEEEIKIAKELFRVQEKGRDAARAVQLQKQKEEEERKKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HW60</accession>
    <name>E9HW60_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_334673</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Shapiro H."/>
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                <person name="Smith Z."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Manak J.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Znf_CCHC"/>
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        <property type="entry name" value="Znf_CCHC_sf"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX61478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="201" mass="22486" checksum="F3717DE3528F8CF9" modified="2011-04-05" version="1">MGVDEPVMSYCYDIIYLCSKVDPTMAEERKVQFIFQNMEPTLMQKVFPQMDRMDTTELFRRLQAHSQAALIAGRSIPVNQILPTPPASSKADIEKLVREELSKSLDPIVRKLEETTQSMRTAGESGVGLKRRVLEGGQNWERSGKRAFDGRPICRTCGKPGHIARDCPNPQITCYRCQGSGHIARYCTSSNSGRKSGAQSE</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX60570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="114" mass="13888" checksum="B9EB1E15F12BE881" modified="2011-04-05" version="1">MSNRDPGFDYRFGYDYPEFPYPYYSEDYDQYQERSPLRRHDVLDPYHYARGMPQVQFYPDHADPFRSHHNYDPRFYPTLKEYEDECYDEWEDEEGHGQVETGGKWLPKNPPGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9I6A6</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX60474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="349" mass="39228" checksum="5CAEAD7FE9391D95" modified="2011-04-05" version="1">MKIGNRNLFLEVGQFLPRETLFWIGRRSYRWEGFWLIGMTIANNEGPGLGIYNFDVGNGIRASAAAFYTVSYSGGPIQSALDFRLEEIPLLDGKLGFISNLTQSGARDAGTGTQSYAPMKGFKFAVMHKAWKPSASHQFAAMIGRGLFGVMDSPDFDQGPLADSLGPWRNNQLFSASAPSELRDAVQDSRLLRVGEQFSWYPQGKDFSLDAAIGWQRADFGGWRYTIDDQIYERPPMQAVAAAIRPMYQIRSTLELETLLGYVAVTDGFGYRHREGDGDLQETIRPVDQSLVNLYMALNLKPLARWQQKFGIYTGYSFWNDAMRRDVSNGLYPGRNSGFYLGLSSYWEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
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    <name>E9I7Q2_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX59978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX59978"/>
        <property type="gene ID" value="DAPPUDRAFT_346066"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_346066"/>
    <dbReference type="HOGENOM" id="CLU_1416455_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003242181" evidence="1">
        <location>
            <begin position="19"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX59978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="192" mass="21445" checksum="5C89DDFBE606325C" modified="2011-04-05" version="1">MFLLRILSLTLVFTATGGIFLAHADLEHKEHFAREVRSVSVVPPDSQPPMTQESIDIALKMFAIEVPDTATHPRLDLNLEDRGLTTLNGWGSKLDVTLGPAAFSSWALLGSTLAHELEVHCLQNFFVIRVKDILGLKGTDEAEREAYLHELANSNRFHLNQNDKINIKATMEYYYPSAQPFDEALSARRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRL3</accession>
    <name>E9FRL3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_309476</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX89866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89866"/>
    <dbReference type="EnsemblMetazoa" id="EFX89866">
        <property type="protein sequence ID" value="EFX89866"/>
        <property type="gene ID" value="DAPPUDRAFT_309476"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309476"/>
    <dbReference type="eggNOG" id="KOG2532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_11_1"/>
    <dbReference type="InParanoid" id="E9FRL3"/>
    <dbReference type="OMA" id="MICAKES"/>
    <dbReference type="OrthoDB" id="497052at2759"/>
    <dbReference type="PhylomeDB" id="E9FRL3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:anion transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX89866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="392" mass="42753" checksum="C86FC707D94CA3F1" modified="2011-04-05" version="1">MAIVCMNRRTKTWNGSEEINSNSSFGFLEFNGTCSDAIKDKEMYLDKTSQGMLLGALYYGVVSVQLLVGWLCDKFGKYKLQMALGSGVLGIASFLSPIILEFAGVPYYFALRVLKGIATSFAISSMLPMLTRWTTTQEQGLLVGIASAGVGVANSKRRVIPWGKMLRSVPVWSVIITNFFFFAVVKGIVLNLPIYVKDVLDFTVTENGIFSAMPLVGALVLHLAAGPIFDYVRTKNIYSPTTVRKIFHVVGTLTPGALMFISSQLTQEHKYYIISLITVGYSLTEFAVMGGYNFAMMDIAPDYLGVLQGINKTISLAPGFIIPMIISALTPNGSEEEWANAFILFGALYVTSCLIFVLTGSAQLQSWGKAIKGDMICAKESCKNFSNNSASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9FTA2</accession>
    <name>E9FTA2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_303171</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM59 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89681">
        <property type="protein sequence ID" value="EFX89681"/>
        <property type="gene ID" value="DAPPUDRAFT_303171"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303171"/>
    <dbReference type="HOGENOM" id="CLU_934661_0_0_1"/>
    <dbReference type="InParanoid" id="E9FTA2"/>
    <dbReference type="OrthoDB" id="1102891at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022065">
        <property type="entry name" value="Uncharacterised_TMEM59"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28652">
        <property type="entry name" value="PTHR28652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12280">
        <property type="entry name" value="BSMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240534" evidence="5">
        <location>
            <begin position="24"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX89681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="298" mass="33326" checksum="1128B3AD6E214C9B" modified="2011-04-05" version="1">MKRAANCLFAGFVVLALGSIVSGMENNIIISKGYVSKLCIDRCQSSETELVEDCERGCRFFEYAETADLVDFNETAFHLLCVSNCNEAYVVEKNRGVCVSGCNFAKKEVDNIMEMSHHLLEEAEKQMNFLNSIIGMVSSTFWSTEDNENDVPKDLQHSRVSGQLLDLLGDIPTRGNKLDDKFSAGDVEIINLMGDDMSSVDPAEMTLCATRLWLHRLSFILIVMGSISLLFISIFYLLAFMKHKKSKEIQETTDDTGDLTSLNPPSYETLIKSGYIVEADNYMAPPLNDEKKEKIFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUA0</accession>
    <name>E9FUA0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_233987</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88958">
        <property type="protein sequence ID" value="EFX88958"/>
        <property type="gene ID" value="DAPPUDRAFT_233987"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_233987"/>
    <dbReference type="HOGENOM" id="CLU_2335740_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="98" mass="11142" checksum="4EEE2153475D7C4D" modified="2011-04-05" version="1">MELQSFPLKSLQHADKSRESCTTTATTTTPPPHLHSLIRRLVRLVLFLSIPQLLFLTSSYAVVESRRTSSGTEREKSIARTNKAETTPIIYKWNTIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9FW25</accession>
    <name>E9FW25_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DAPPUDRAFT_41064</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88997"/>
    <dbReference type="EnsemblMetazoa" id="EFX88997">
        <property type="protein sequence ID" value="EFX88997"/>
        <property type="gene ID" value="DAPPUDRAFT_41064"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_41064"/>
    <dbReference type="eggNOG" id="KOG2082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001883_1_1_1"/>
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    <dbReference type="OMA" id="KNWRPHI"/>
    <dbReference type="OrthoDB" id="349744at2759"/>
    <dbReference type="PhylomeDB" id="E9FW25"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0045202">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
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    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0071477">
        <property type="term" value="P:cellular hypotonic salinity response"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0007268">
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:1902476">
        <property type="term" value="P:chloride transmembrane transport"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:potassium ion import across plasma membrane"/>
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        <property type="entry name" value="AA-permease/SLC12A_dom"/>
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        <property type="entry name" value="KCC3"/>
    </dbReference>
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        <property type="entry name" value="KCL_cotranspt"/>
    </dbReference>
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        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
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        <property type="entry name" value="PTHR11827"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTHR11827:SF66"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="KCLTRNSPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00930">
        <property type="entry name" value="2a30"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0868">Chloride</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236854" evidence="12">
        <location>
            <begin position="20"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="574"/>
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    </feature>
    <feature type="domain" description="AA_permease" evidence="13">
        <location>
            <begin position="99"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="13">
        <location>
            <begin position="380"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12" evidence="14">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="SLC12" evidence="14">
        <location>
            <begin position="803"/>
            <end position="1032"/>
        </location>
    </feature>
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        <location>
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            <end position="957"/>
        </location>
    </feature>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
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                <person name="Shapiro H."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tu H."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="3"/>
            <end position="50"/>
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    </feature>
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            <begin position="318"/>
            <end position="349"/>
        </location>
    </feature>
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            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX88681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="434" mass="46108" checksum="3A94175C0B8A8D9F" modified="2011-04-05" version="1">MSRHEGVSCDSCIKGNFRGLRFKCLICYDYDLCATCYEAGATNTRHTADHPMQCILTRSDYDTFYGGESISSDTPQSFSCPYCGKLGYTETGLYDHVTSDHTETPYEVVCPICASLPGGEPNQVTEDFAAHLTMEHREEEPGGIGRGVRRIPHPARGSSGPRTRRPNMHFTSTGSVLTSSGSTPGSNSSSSRERDREREREAMDPIAELLSQLSGVRRGLGASGLGSVLGLGALGSLGGALGSLGANLSGQSPGSNNSSLPTPSGRGRLLGLVGRDNAGAFSELVNNGASGQSQPQLERHQALRLPRRQTQVISAPSTFSSTNVTTGVTPNGSSSMIPTTASVGSPDSTNNSQLLLSRLGNVLKDDRKESNSKSCQDRSLFIQDLILSTLAAGFELDIDRDLTTPLSSVELSRDILTTDRPEKNDVAVSRGEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYQ2</accession>
    <name>E9FYQ2_DAPPU</name>
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        <submittedName>
            <fullName evidence="10">ABC protein, subfamily ABCA</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">DAPPUDRAFT_312055</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:lipid transporter activity"/>
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    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030369">
        <property type="entry name" value="ABCA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="PTHR19229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF49">
        <property type="entry name" value="PTHR19229:SF49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="639"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="780"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="1643"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1672"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1702"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1788"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="907"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1847"/>
            <end position="2079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1245"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2160"/>
            <end position="2183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="940"/>
            <end position="947"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="1881"/>
            <end position="1888"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX87570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="2199" mass="247646" checksum="009FA405E29840A9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1F6</accession>
    <name>E9G1F6_DAPPU</name>
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        <recommendedName>
            <fullName evidence="12">Peptidase_M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_312745</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M14 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="MEROPS" id="M14.A18"/>
    <dbReference type="EnsemblMetazoa" id="EFX86827">
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        <property type="gene ID" value="DAPPUDRAFT_312745"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312745"/>
    <dbReference type="eggNOG" id="KOG2650">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019326_2_1_1"/>
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    <dbReference type="OMA" id="MIFTPWG"/>
    <dbReference type="OrthoDB" id="524270at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="M14A-like_propep"/>
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        <property type="entry name" value="M14A_act_pep"/>
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        <property type="entry name" value="Peptidase_M14"/>
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        <property type="entry name" value="Propep_M14"/>
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    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
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        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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    <evidence type="ECO:0000313" key="13">
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
    <sequence length="421" mass="47932" checksum="1AC8AC9F82F72BC9" modified="2011-04-05" version="1">MSLLFTLLVLTCAFVVDQVSTEEDKAVSYSGYQVWRITALSKEEHQAVLKMIEHFGLELWRWQESQTINTPIDVLVPPQSQIKVKQQLDEANISFVVKVADLQEDINDENPNLNASSYNTKAAHRMDWMSYHRLDDIYGYLNYLADTYPNIVQLINIGASYENRTLYVVRISNSSKPDTQPAVWIDGGFHAREWITHALATYIIQQLVEEPANAKLLFNIDWYIMPVVNPDGYEYSHVINRLWRRSRSNTGSRRCQGVDLNRNFDFKWGGPGSSNNPCADTFKGSKAFSEPEAVAYSKFIKSKSNQIKLYLSLHSYGQLILLPWGYEREYPSDYNETLALANLAASKFRAFSYRVGTTVDLLYRASGNSADWAKSIGIKYVYTVELPIRGFVLPASFILPVSKDFFPALDVLASKISTIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1W3</accession>
    <name>E9G1W3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cubilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_221966</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX86741"/>
        <property type="gene ID" value="DAPPUDRAFT_221966"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="E9G1W3"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="23"/>
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        <property type="match status" value="25"/>
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        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
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        <property type="entry name" value="EGF-like_dom"/>
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        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
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        <property type="entry name" value="EGF_Ca-bd_CS"/>
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        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
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        <property type="entry name" value="Sperma_CUB_dom_sf"/>
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        <property type="match status" value="25"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="8"/>
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        <property type="entry name" value="SSF57184"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="24"/>
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        <property type="match status" value="4"/>
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        <property type="match status" value="3"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
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            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236586" evidence="8">
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            <end position="3519"/>
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    </feature>
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    </feature>
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                <person name="Thomas W.K."/>
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                <person name="Geiler-Samerotte K.A."/>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Tsuchiya D."/>
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                <person name="Arnold G.J."/>
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                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
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        <property type="protein sequence ID" value="EFX83556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX83556"/>
        <property type="gene ID" value="DAPPUDRAFT_47691"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_47691"/>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012184_8_1_1"/>
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    <dbReference type="OMA" id="CHIEEYV"/>
    <dbReference type="OrthoDB" id="1275401at2759"/>
    <dbReference type="PhylomeDB" id="E9G9G3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54001"/>
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    </dbReference>
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        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
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    </dbReference>
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        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
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    </dbReference>
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        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Pept_C1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX83556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="211" mass="22842" checksum="FB9185C5F55AB49B" modified="2011-04-05" version="1" fragment="single">LDYRNDTCLAAIKNQGQCGSCWAFAAIAPLEFAACKKNKSSAAVPEQQLVDCDTVDGGCNGGFYTNAWDYHKKANGSAKSSLYGYTAVKGTCKFNSSMVGAKVASYTKVQVKNSTAMQTALVNYGPLAVAITVINSFQYYSSGVYNDVACNNQTINHAVTIVGYGVQNTTINYWVVRNSWGTGWGQKGYILMLRGTNLCHIEEYVYYVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAH5</accession>
    <name>E9GAH5_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX83243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315684"/>
    <dbReference type="HOGENOM" id="CLU_2225824_0_0_1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX83243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="106" mass="11557" checksum="EB37F139FDE3C900" modified="2011-04-05" version="1">MASTKTRISFEGWIIITAVVLIVASAIGMICVDQVNRASIEECNLHIDCSSSLNPQTAQMKADASLIRAAPDDKSPSQPETRTETSDIILPSISIPPEKREYILSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GCC3</accession>
    <name>E9GCC3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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    <organism evidence="2">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX82524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82524">
        <property type="protein sequence ID" value="EFX82524"/>
        <property type="gene ID" value="DAPPUDRAFT_240720"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_240720"/>
    <dbReference type="HOGENOM" id="CLU_2160889_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX82524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="111" mass="12770" checksum="7EF08E7B8991562F" modified="2011-04-05" version="1">MFRDDLEFLDWHDRLYEKSCHLKKKDKDYTVNKSPPFSFQVNLAPLIHRLNPLVETEQRSVTTDRRVCISNTAHIVPSFRCPEAWCLLQLRGQNNSTSTTQPTASGGSTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9GCY9</accession>
    <name>E9GCY9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_210528</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Choi J.H."/>
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                <person name="Geiler-Samerotte K.A."/>
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        </source>
    </evidence>
    <sequence length="394" mass="44702" checksum="CF1652FD09663CF0" modified="2011-04-05" version="1">MKNQERNVSSNFLDNLNVEFSSNSHSFLSRFDLNGSDSSDEDESDTSNDNLTKSGGKSSYELRQERLKAKIQELEDEAVAPKPWQLMGETKAELRPDNALLEEDLFFDHTTRQAPVITEETTKTLEEIIRQRIKDQAFDDVERKIKPVYDPTEFKKKLVLDQEKSKFSLAEIYEQEFLKQQETQKAEAKSSSLADVPNDEASEDQNRAALRKRMATVFAKLDALCNFSYTPRAPEPDVKIVSNMPSIVMEEIAPVTVSDANLLAPQEVQDPTRGVLKGTTEKAKTDRLRERRKKKSAQRVRHKERERTEKAVDKANPGLGNKHAKARVLHNLQKAEKEGTVSLIKDNRTKATKSSTAFFKQLQEDVSASVDAVRQGKQKTNLKNKRSTGSQFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9GG06</accession>
    <name>E9GG06_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-hydroxyacyl-CoA lyase 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IlvB-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_303446</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R)-hydroxyhexadecanoyl-CoA = formyl-CoA + pentadecanal</text>
            <dbReference type="Rhea" id="RHEA:55212"/>
            <dbReference type="ChEBI" id="CHEBI:17302"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:138654"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:55213"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal</text>
            <dbReference type="Rhea" id="RHEA:55196"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:74116"/>
            <dbReference type="ChEBI" id="CHEBI:138631"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:55197"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732543">
        <property type="protein sequence ID" value="EFX81316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81316"/>
    <dbReference type="EnsemblMetazoa" id="EFX81316">
        <property type="protein sequence ID" value="EFX81316"/>
        <property type="gene ID" value="DAPPUDRAFT_303446"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303446"/>
    <dbReference type="eggNOG" id="KOG1185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_3_1"/>
    <dbReference type="InParanoid" id="E9GG06"/>
    <dbReference type="OMA" id="CFGTSGP"/>
    <dbReference type="OrthoDB" id="1132247at2759"/>
    <dbReference type="PhylomeDB" id="E9GG06"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_N" evidence="12">
        <location>
            <begin position="54"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="10">
        <location>
            <begin position="276"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="11">
        <location>
            <begin position="468"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX81316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="634" mass="68449" checksum="0ED30252CA5EEB1E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIX3</accession>
    <name>E9GIX3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DAPPUDRAFT_224638</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FRRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80339">
        <property type="protein sequence ID" value="EFX80339"/>
        <property type="gene ID" value="DAPPUDRAFT_224638"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_224638"/>
    <dbReference type="eggNOG" id="KOG4293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028305_0_0_1"/>
    <dbReference type="InParanoid" id="E9GIX3"/>
    <dbReference type="OMA" id="YTTHYIL"/>
    <dbReference type="OrthoDB" id="599276at2759"/>
    <dbReference type="PhylomeDB" id="E9GIX3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51019"/>
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        <source>
            <dbReference type="EMBL" id="EFX80339.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
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    <sequence length="544" mass="60137" checksum="3D6AF30A9C6B0D34" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJ91</accession>
    <name>E9GJ91_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_103423</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX80406.1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="85"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="241" mass="24692" checksum="21A18E45C93AF8E0" modified="2011-04-05" version="1">MASGKSKTSAFCIDSLLAQDKLPSADSVMPSQSAQAAAAAVAAHQQLIVSSYGDSIRFRSNLFGGLHHHHYPSFETSVESNHKVLPSSDSVASVEGDCKETDGRQSSSSSSVNKEDGPANEREGGHQSSLVTQPGSLSCWTQPHSMSRMIYGPPTSSCAPTVSSSLTTSSSATTASSSSSLTNYAGPLFTSPAAALHAAAAAAAAAVAASSPAAHQFHSAHLEWLARAGVLYHRFGGDLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJB7</accession>
    <name>E9GJB7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="5">MAD homolog</shortName>
            <shortName evidence="5">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_304115</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the dwarfin/SMAD family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX80419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80419"/>
    <dbReference type="EnsemblMetazoa" id="EFX80419">
        <property type="protein sequence ID" value="EFX80419"/>
        <property type="gene ID" value="DAPPUDRAFT_304115"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304115"/>
    <dbReference type="eggNOG" id="KOG3701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026736_1_1_1"/>
    <dbReference type="InParanoid" id="E9GJB7"/>
    <dbReference type="OMA" id="CWIEVQI"/>
    <dbReference type="OrthoDB" id="905048at2759"/>
    <dbReference type="PhylomeDB" id="E9GJB7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="PTHR13703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SSF56366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="7">
        <location>
            <begin position="14"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="8">
        <location>
            <begin position="295"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="524" mass="57603" checksum="76A5639CC1E7AB78" modified="2011-04-05" version="1"> </sequence>
</entry>
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        </lineage>
    </organism>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
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                <person name="Tsuchiya D."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="77" mass="8689" checksum="1C925A88A1BC54C5" modified="2011-04-05" version="1">MNLMSKRNSIILQMRHLEVFSISAMLVVLVFVFTATANQADKHVTEMVHKSKHASEDHHDAAGKVDDVKTLVARLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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                <person name="Manak J.R."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Dong Q."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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                <person name="Dong Q."/>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
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                <person name="Tsuchiya D."/>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Koonin E.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Thomas W.K."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Koonin E.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX78494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="576" mass="64975" checksum="19C1522186C86EEB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQH7</accession>
    <name>E9GQH7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_246435</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732558">
        <property type="protein sequence ID" value="EFX78333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78333"/>
    <dbReference type="EnsemblMetazoa" id="EFX78333">
        <property type="protein sequence ID" value="EFX78333"/>
        <property type="gene ID" value="DAPPUDRAFT_246435"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_246435"/>
    <dbReference type="eggNOG" id="KOG1027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025010_0_0_1"/>
    <dbReference type="InParanoid" id="E9GQH7"/>
    <dbReference type="OrthoDB" id="1115202at2759"/>
    <dbReference type="PhylomeDB" id="E9GQH7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="PTHR13954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX78333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="508" mass="57580" checksum="027CAD61AA01A1C7" modified="2011-04-05" version="1">MEIQLDVKVRLGKGAFGAVFPGTFRGRQVAVKRVDLFDANGNEEETLKQLDHPHIAKLFHVESNDEFKYFALELCAASLDQIFLDPENPRKYKGPNLPPHLMVFSQLASGLDYIHSKKLIHRDIKPENVLIHVDPTTGQVKMKWADFGLSRSVNERGTFTINSGIKGTKNWYAPELLKLSSEFKKKKLPRGTVKSDVFAQGLVFAYLLLDGLHLYGRNDYEIFMNIMADNPVNTSSKLSQHDSKSQIHNTDFEIDQPHYALELFTKMLAHDHEVRISSGDVATQLNTIKEKLAEKEEEVRLLSKFKILDLNQIKSLIRFGIDVNGKDEDGNNALHLLCTNHSSERLIEAITPLIESKIDVNGENNYGSNALHLLCLNNSSKGLIEAMKLLIQQGIDVNRKDNYGRNALHYLCFSNSSDKLIDAIQLLIQHRIDVHGIDKDGWNALHLLCRFNSSQRFTEAIKLFIQFGIDVKSNGIDARILLRNNSTFNQREITDDILQLLDRAALVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9GR53</accession>
    <name>E9GR53_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">40S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_92887</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732559">
        <property type="protein sequence ID" value="EFX77948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77948"/>
    <dbReference type="EnsemblMetazoa" id="EFX77948">
        <property type="protein sequence ID" value="EFX77948"/>
        <property type="gene ID" value="DAPPUDRAFT_92887"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_92887"/>
    <dbReference type="eggNOG" id="KOG0877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_0_2_1"/>
    <dbReference type="InParanoid" id="E9GR53"/>
    <dbReference type="OMA" id="DLKNWVP"/>
    <dbReference type="OrthoDB" id="1197354at2759"/>
    <dbReference type="PhylomeDB" id="E9GR53"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_S5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="8">
        <location>
            <begin position="90"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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</entry>
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                <person name="Dong Q."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Robertson H.M."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="211" mass="23869" checksum="411D21155B5386C8" modified="2011-04-05" version="1">MSRPLTANSRNEAEMMSKAKRQQTMAQDPLEKLRCQLLARGATGIIGFGKVFRRMDDDGNRSLCYEEFRKGIEESGVKTEDGSRALFDAFDKDGSGSVCINEFLKAIRPPMSEGRKRVIAEAFKKLDRTGDAIVTLDDLNGVYNVKHNPRYLSGEETEEQILKKFLANFESNGSIDGMVTYDEFLDYYAGVSSSIDHDAYFDLMMRQAWKI</sequence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Dusheyko S."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
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                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2006183_0_0_1"/>
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        <source>
            <dbReference type="EMBL" id="EFX77302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="124" mass="13455" checksum="CBD1CFC18863CC1A" modified="2011-04-05" version="1">MDFEYAAVDNCPENIDEDSTDPLAVLPQMTVEFPPSAGNQDHAVAMDVDFGETDDVAGHSESGLFRSSFTALKTTFTKKSARRAATDLLAALYSPLYMEMHKRTATPTKGHDCEDVAIPLPGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
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    <name>E9GUM6_DAPPU</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX76911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76911">
        <property type="protein sequence ID" value="EFX76911"/>
        <property type="gene ID" value="DAPPUDRAFT_321942"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_321942"/>
    <dbReference type="eggNOG" id="ENOG502S8GQ">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="140"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="216" mass="24612" checksum="05A19BC20B467BA3" modified="2011-04-05" version="1">MKKLITGSWRNGSFDTNKFAKSILLFRNAPRSGAASPAQMVFNRPVRDALPAHRRSFAPEWQLKADILEKRARRAKEVQIEHYNRTAHPLQPFGIGDHVIVQHPVSKCWATTAIVVEIGPNRDYIVKTPAGRLFRRNRRMLRKRCEKRKKMPVMPGNPPAGPSIQPAPTPPEENPPGSNETAGTTRRKRGKDKRTPSNDTPRRSTRQTKRPTRYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GWC0</accession>
    <name>E9GWC0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732570">
        <property type="protein sequence ID" value="EFX76218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76218">
        <property type="protein sequence ID" value="EFX76218"/>
        <property type="gene ID" value="DAPPUDRAFT_249283"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_249283"/>
    <dbReference type="HOGENOM" id="CLU_1715114_0_0_1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX76218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="153" mass="16421" checksum="BAAAA0D173CF782A" modified="2011-04-05" version="1">MTNRQMLIAVLSLFVLQAQFVSPSPTDSRLVKRQSLQSDSTLFLDSVGDLAVGSAALPPLLNVTRAFTRVQQSSTRLFNNTQSVVPEPGTLRDVTRRIAQGIQPAIGLVGQSVNSTFRRTSGNGILGAFGGSSNTTRVNPNDSEIPPEGFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GWI7</accession>
    <name>E9GWI7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732570">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX76180"/>
        <property type="gene ID" value="DAPPUDRAFT_306288"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306288"/>
    <dbReference type="HOGENOM" id="CLU_1541688_0_0_1"/>
    <dbReference type="OrthoDB" id="1809271at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237545" evidence="1">
        <location>
            <begin position="20"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="174" mass="19699" checksum="4BB7399E559A2ADE" modified="2011-04-05" version="1">MKKITTILVVSVLAVLSSSSENSFVTQQWNRNPAMRNRAFYYFHPTHLPGTQFYPKIPLVNYYPYFPIAEPNKLRLNEDSQMSDIANSRPTTPTPPPLLIDQNLSDEEAMTQLEILKEIYTRNNENGVVLPSILPSSRGFIALKTTAFISFLNSFSLAATTKTKTKIFVYPTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9GWS5</accession>
    <name>E9GWS5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PhoLip_ATPase_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_322710</name>
    </gene>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_322710"/>
    <dbReference type="HOGENOM" id="CLU_1604406_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
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        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoLip_ATPase_C" evidence="1">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="166" mass="19702" checksum="C7E58F3B3F340A44" modified="2011-04-05" version="1">MEAVLASDYTLVQFRFLERLLLVQGRWFIRMNCQNVMGDIYPRTYHGETNDRSKEKEDYLTQKFNNCSYENKIWLRKYKSLKDKLTMVMDEEKIFLVKLDKENEPLLPKTLHIYVPSSASGTVFGSMQELTSVAELEAEESMMLDYLVKMEDIKIRVNRRISPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GXF7</accession>
    <name>E9GXF7_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_107537</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX75863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75863">
        <property type="protein sequence ID" value="EFX75863"/>
        <property type="gene ID" value="DAPPUDRAFT_107537"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_107537"/>
    <dbReference type="HOGENOM" id="CLU_2029025_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="122" mass="13861" checksum="912747C917CA86C8" modified="2011-04-05" version="1">MGKIEVERFMKLRSVANVAKDFFVIVHIERLSSATAIAVREGVDRVLPENQCKLLLLAQHHHRFLSTKALGARLGLVFDRLIEINVTADQLRQFFSIILPNAVNLHFFPSKFSSCGERKQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GXX4</accession>
    <name>E9GXX4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX75735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75735">
        <property type="protein sequence ID" value="EFX75735"/>
        <property type="gene ID" value="DAPPUDRAFT_306686"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306686"/>
    <dbReference type="HOGENOM" id="CLU_2017520_0_0_1"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241369" evidence="1">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="123" mass="13983" checksum="AA891B163B0D9CE4" modified="2011-04-05" version="1">MSAAQCNKIFLISAVLVMVAAILPAEAIRTWDDWHNGDDGIKWMYNCEFPGAWTLEAKEFNSDYSPMEESKCGRACIDRRGCNSFVFREGTCFLKSSSIPGSYKPYRLCNQCDSCGFLPWKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
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    <gene>
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    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">PA42</strain>
            <strain evidence="6">TCO</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">Cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732576">
        <property type="protein sequence ID" value="EFX75310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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</entry>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Geiler-Samerotte K.A."/>
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        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74579.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="121" mass="14187" checksum="B63ABC4E3C238A5F" modified="2011-04-05" version="1">MSETSMRRKEFSAIVERWERSVKDDQEELERAKQAEEKQLSEIGKEIKKMEDIVIPMSLGNMEDIGQDSNMLPEAVEKLDLAGEKLQETNTEFEKARAKTKKAQQAFERVKQERFDLYVLF</sequence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX74312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX72865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="217" mass="24467" checksum="813C2BD26BDC4186" modified="2011-04-05" version="1">MSKLVCWNKDVNFSIQDVPGAPEDISVHDIFQDSCVLKWKKPKDDGGMPIVNYIIERQDLSVKGGWNPVSESPVNQPLSFKCERLINKKEYKFCVVAVNKMRNSEPVYFPKFSLPKILGMNQGNQAMLKSSTGMLITQILHGLSLKMTEVLRSLAMSLNIRYSHWFIGMTNKSDDEFGEIDSREAPSDSETEEDTKGSEEDGCSDEDEESGKDEQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="InParanoid" id="E9H767"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX72419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="81" mass="8744" checksum="51BC7F84B4386665" modified="2011-04-05" version="1" fragment="single">EARSPSKCFPPRKTGPPRKACTPREAGSPRETARSPSKGFPPRKTGPPRKACPPREAGPPWETCTPREAGSPRETGLPREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9H7S4</accession>
    <name>E9H7S4_DAPPU</name>
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        <recommendedName>
            <fullName evidence="2">CUB domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_59268</name>
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    <organism evidence="4">
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            <taxon>Anomopoda</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Salamov A."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
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                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    <dbReference type="OMA" id="NDEICEW"/>
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    <dbReference type="PhylomeDB" id="E9H7S4"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX72252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="102" mass="11241" checksum="41B3820E3241BE2F" modified="2011-04-05" version="1" fragment="single">SGTIKSPNYPMPYPHLTDCRWTIRVKPGSKVRLLFAFFETQQGVDFISVYDGPTVNEKLLMTESGSVPTPFVVNSSTNQVLVRFTSDGDTSLSGFLAVYSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9G9</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Cladocera</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732608">
        <property type="protein sequence ID" value="EFX71615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71615">
        <property type="protein sequence ID" value="EFX71615"/>
        <property type="gene ID" value="DAPPUDRAFT_227837"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_227837"/>
    <dbReference type="HOGENOM" id="CLU_1779333_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237914" evidence="1">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="146" mass="15536" checksum="DBC639F6C103A984" modified="2011-04-05" version="1">MLLGPLILSLVLVVVAVSGLPISPASTYQVDEVIKTSDLSSISIPSYRIVQPASKGVNPKIEYDFLPFISAPPLKESDEVLVNSASAESEEPNRFGIVESDESEEELLNKPLLPLLPAAETAVIVVPTTNSPTQLEALPELTTVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9HB35</accession>
    <name>E9HB35_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_112167</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732614">
        <property type="protein sequence ID" value="EFX71015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71015">
        <property type="protein sequence ID" value="EFX71015"/>
        <property type="gene ID" value="DAPPUDRAFT_112167"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_112167"/>
    <dbReference type="eggNOG" id="ENOG502SS2Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098783_0_1_1"/>
    <dbReference type="InParanoid" id="E9HB35"/>
    <dbReference type="OrthoDB" id="1924622at2759"/>
    <dbReference type="PhylomeDB" id="E9HB35"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="133" mass="15370" checksum="9A906EA3CC3AFDAD" modified="2011-04-05" version="1">MNLSDRLDRLDDQAERVKVAYDQHARRLRPLRVGDSVRVQDADSKRWDKQGIIVSVGESCDYRIKMQSGRIYWRNRKFLRLVYPPLAIDADPADPSPAMDAKPEEPVPLPPPDHSASQRHRRVNFDLPPCRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCF6</accession>
    <name>E9HCF6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_61068</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS35L family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732619">
        <property type="protein sequence ID" value="EFX70615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70615"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_61068"/>
    <dbReference type="eggNOG" id="KOG3682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012270_0_0_1"/>
    <dbReference type="InParanoid" id="E9HCF6"/>
    <dbReference type="OMA" id="MANLEWV"/>
    <dbReference type="OrthoDB" id="247677at2759"/>
    <dbReference type="PhylomeDB" id="E9HCF6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029705">
        <property type="entry name" value="VPS35L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673">
        <property type="entry name" value="PTHR13673"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX70615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="861" mass="98913" checksum="95C2151F4B198851" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCX0</accession>
    <name>E9HCX0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_257138</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732621">
        <property type="protein sequence ID" value="EFX70428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70428"/>
    <dbReference type="EnsemblMetazoa" id="EFX70428">
        <property type="protein sequence ID" value="EFX70428"/>
        <property type="gene ID" value="DAPPUDRAFT_257138"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_257138"/>
    <dbReference type="eggNOG" id="KOG3656">
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69909"/>
    <dbReference type="EnsemblMetazoa" id="EFX69909">
        <property type="protein sequence ID" value="EFX69909"/>
        <property type="gene ID" value="DAPPUDRAFT_113206"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_113206"/>
    <dbReference type="eggNOG" id="KOG2042">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_675408_0_0_1"/>
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    <dbReference type="PhylomeDB" id="E9HEC3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030433">
        <property type="term" value="P:ubiquitin-dependent ERAD pathway"/>
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    </dbReference>
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        <property type="entry name" value="UBE4"/>
    </dbReference>
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        <property type="entry name" value="PTHR13931"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX69909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="408" mass="45941" checksum="E30A0B67E03CD412" modified="2011-04-05" version="1" fragment="single">MSELTQEEIRQRRLARLAVMSTGVAPMSNPSLSSASTSSQPSNAIFMENVSMLYTPSTPVKNYPMDIDGTTPRKIEAMDMDGATPRKIEAMDTDEPATGTPSKVQSNADTLCTEDFLNTTVTKILCVSRKPEKSCIVLSAIWPNNPLVTSVGFVNNHYILETVGDMIMESLDIIMYSLEKPNQLFQEGSEINCLQYLIDCYTRMEEHMKKYSKKCSISSVKELLVKIKTELCAALALLLEGFLTEPIKKDYYNILYEHLKRHSLPSEFFYELVHHLESDYVRFTKIFSPLLLVIRKESQQGSVSDSSHTAALQVLSDLCECRTGVNSSTRPFCNLMIKMGNWLVEPLTEATGREFAKFTFLGPFLCTSLFAEDDCRIADKLKTTANESRPIVSSLQQEVELTRNLLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9HEC9</accession>
    <name>E9HEC9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Focal_AT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_257869</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732628">
        <property type="protein sequence ID" value="EFX69914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69914">
        <property type="protein sequence ID" value="EFX69914"/>
        <property type="gene ID" value="DAPPUDRAFT_257869"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_257869"/>
    <dbReference type="HOGENOM" id="CLU_055889_1_0_1"/>
    <dbReference type="InParanoid" id="E9HEC9"/>
    <dbReference type="PhylomeDB" id="E9HEC9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007172">
        <property type="term" value="P:signal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Focal_adhe_kin_target_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005189">
        <property type="entry name" value="Focal_adhesion_kin_target_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03623">
        <property type="entry name" value="Focal_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68993">
        <property type="entry name" value="SSF68993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX69914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="274" mass="28899" checksum="DBA34CF249C5219B" modified="2011-04-05" version="1">MVKRAFQASTGSAGNGQDLPPPKPSRVPATYVGIGGSAGKSVPSASSEQSLSGPTTYLVAPNSEVLAQLMRDNETPADAGHYTAPASAFNRFTVEFSHTSSSNSNPASPQHKSKTNGRKNQPVYANIMMADVTPPSAAAAVATNPAPYKDVRISACRVEQQHTSPNQRTISRAHSKKDECSSGSCANGNRKRTVAASSSYRSDTDSMDGANASTPLQGNQLDSRSVIVKKLEPTPTALLDRTHDKVYDATSVVRAVMLLSQGVQQPKLKTTLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HEM8</accession>
    <name>E9HEM8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_258012</name>
    </gene>
    <organism evidence="2">
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        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732630">
        <property type="protein sequence ID" value="EFX69785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69785">
        <property type="protein sequence ID" value="EFX69785"/>
        <property type="gene ID" value="DAPPUDRAFT_258012"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_258012"/>
    <dbReference type="HOGENOM" id="CLU_1166860_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HEM8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX69785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="238" mass="27376" checksum="9BAA17D55422EE01" modified="2011-04-05" version="1">MTKLDNKWTYTEEPEAIGYWLRTVTVEKINCLLEEISIAHEDESDIINTPLGKANISERVISHNHMTLFWIDTYAKPTNIVLRELEKGVGSWYESSTKDTWILQDNDNQLDFHVKLIPRCQNVKCDKTIPSWTVVSNNHLFIVQSMVGKAPPAPKKPVFYTSPNFWENAQLINDHQNFNIQFLTDTAVRHENELIRVIQSVQCEQRRIKHAQAVSTAQYCHGLVNAGFTLLWPNSGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HG32</accession>
    <name>E9HG32_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_329254</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732638">
        <property type="protein sequence ID" value="EFX69320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <dbReference type="EMBL" id="EFX68698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="390" mass="44155" checksum="FB746D2E1FABE3E5" modified="2011-04-05" version="1">MPGITDVSFLQMKRNNTLFNYTAKNLAQGIFFGRRECPFERRAIHSARPDYRAGQRYSNSSYGKPYSGQNIPTPVNETVIRNPSCPMTCLIKRMAEYRKAKNTSIELNSASDHSVHPRCDARLDTEFTISPIDVLEQQIIVTPGSEENGDQTSYFARPVPIVESSLEDASESDKTNSGVGGWEYHEALKKRPKKDPCQAIAWQQSGQNYHIVKNHICQNEHHKKIRMATLASIAEPLLLKAVKANLGATLPGFHAIAAAGKRLLLAEEKNADVISFSPPVCLLYVFMSEKRETIDYVKILKAILTLLDHQTAVEEVVTDFERSTWRAFEQPGIWSPEPWSVFFQIIRTNNDAEGWYNKLNKKGKGAGLHFYKLVQMLYLESEFVEVENLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="91" mass="9848" checksum="90900F2F2171AAEE" modified="2011-04-05" version="1" fragment="single">PTFSTKPKSCYARAGQTAKFEGCVQGIPLPIISWQKADEVIVESEQFKMESAEDGTFSLTISNVQETDYAEYSTKATSAVGENSATAVIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9HI65</accession>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
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                <person name="Jogdeo S."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_329968"/>
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    <dbReference type="OMA" id="SRFPYCI"/>
    <dbReference type="OrthoDB" id="1452247at2759"/>
    <dbReference type="PhylomeDB" id="E9HI65"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008496">
        <property type="entry name" value="TMEM222/RTE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921">
        <property type="entry name" value="PTHR20921"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF778"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="189" mass="21373" checksum="6C19292A13437EA2" modified="2011-04-05" version="1">MATSGSTYQFFDFKDELLDITKPFVIISNDVRKNRYPFCIVWTPIPLITWIFPFIGHMGICTSSGIIRDFAGSYFVSEDQMAFGDPTKFLQLSMSKVPGGVSAWDRAIQDASEEYKSHMHNLCCDNCHSHVALSLNNMAYPGKRNWNMVAVCWQMLFHGKHIGCSGFLRTWAPSIFLLTVIAVIVIFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9HIL5</accession>
    <name>E9HIL5_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_114576</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732656">
        <property type="protein sequence ID" value="EFX68422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68422">
        <property type="protein sequence ID" value="EFX68422"/>
        <property type="gene ID" value="DAPPUDRAFT_114576"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_114576"/>
    <dbReference type="HOGENOM" id="CLU_2252722_0_0_1"/>
    <dbReference type="InParanoid" id="E9HIL5"/>
    <dbReference type="OrthoDB" id="830428at2759"/>
    <dbReference type="PhylomeDB" id="E9HIL5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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    </dbReference>
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        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX68422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="107" mass="11580" checksum="898509A8EB7225D3" modified="2011-04-05" version="1">MAVPSPTTSALLPQVVNKNLFQSLSGALKDFHEHVTLFRNIDGGNIGRVLPKYLSQSTSEKVKAQGVNVLPKANVEGAILEDFKVALTLNDGQKVNSYFSTCFSDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJB3</accession>
    <name>E9HJB3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_114812</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732661">
        <property type="protein sequence ID" value="EFX68173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68173">
        <property type="protein sequence ID" value="EFX68173"/>
        <property type="gene ID" value="DAPPUDRAFT_114812"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_114812"/>
    <dbReference type="HOGENOM" id="CLU_1645424_0_0_1"/>
    <dbReference type="OrthoDB" id="1439534at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX68173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="161" mass="18172" checksum="00E65E845A87F00E" modified="2011-04-05" version="1">MDVNLVLKQNREAILSGEGEVVSVSITSVSMEGDVGKRRVLYDAKTNTRIDYPVVTSKKTPSKPAVGGRGKGKILSLEAKNAPLISVMQKVQNFMEDKKETKWRRMPCVQVKYTETKRNTNICIRKGERCDKTVPTRWANVDGRGLKRALKLRTLTIFTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJW6</accession>
    <name>E9HJW6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_301731</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732665">
        <property type="protein sequence ID" value="EFX67970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67970"/>
    <dbReference type="EnsemblMetazoa" id="EFX67970">
        <property type="protein sequence ID" value="EFX67970"/>
        <property type="gene ID" value="DAPPUDRAFT_301731"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301731"/>
    <dbReference type="eggNOG" id="KOG0885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_14_4_1"/>
    <dbReference type="InParanoid" id="E9HJW6"/>
    <dbReference type="OMA" id="DDWYDVY"/>
    <dbReference type="OrthoDB" id="1392223at2759"/>
    <dbReference type="PhylomeDB" id="E9HJW6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX67970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="449" mass="51459" checksum="CF4E3822E6669719" modified="2011-04-05" version="1">MSNIYVQEPPTNGKVVVTTSLGEIEIELWSKECPKACRNFVQLCLEGFFNGTIFHRVVPNFIAQGGDPSGSGHGGESIYGEPFKNEVHSRLRFVRRGLVATANTGNNDNESQFFFTLGSCPELQNKHTIFGRVAGNTLFNMIKFNDLDIDSEDRPRHPPKIFKTEVISNPFPDIEPRISQENIKKPEEIKSKIIKKKNLHLLSFGDEEEDETDVHQPTKSFRGKSSHELTNDPKLSIVPAVNIEMGLTNNDKPTKIEPQFEKVAPQTDLQPEVSPESVDVDISNQKKSEANNKLKQIKEQIRDLKREMKNPSEISQDQELSKKRKISDSEEDNEILKDFHEQQKKYADIKTTRRGKGTDREAETLNFLKKFQSKLSQTRTTKGGVDDIDDVNDDAWLNHTLKFEDKNPSLARDANTKSDDWFEIYDPRNPLNKRRREESKKIMKEKKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKM2</accession>
    <name>E9HKM2_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_330773</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732670">
        <property type="protein sequence ID" value="EFX67680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67680">
        <property type="protein sequence ID" value="EFX67680"/>
        <property type="gene ID" value="DAPPUDRAFT_330773"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330773"/>
    <dbReference type="HOGENOM" id="CLU_779046_0_0_1"/>
    <dbReference type="OrthoDB" id="238769at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="356" mass="39979" checksum="E74AB0FC84E7B196" modified="2011-04-05" version="1">MYNKYKEAIFRQSLVLSLRGHVDFFFQKAGSCLASQPEGDGADGQPSQIERNFSTVLSAQNVEISSNRLPTETLQAVRIVEPIIEEPSLIVPSSQQSLVSVDSSNVIRFVGSLQSDQHAEDDGQVQHEDAIDQNFGSAPEDFSMKWSGYAGTKMNIALRKFQVQALTALHFSRDIIIVELTDSGNSTCFQLPALTLKDEEFCLVIVPTVALGWDHLKAYEDLGLSATYLGDESTKEQFEDFLSQSLPFYQTGYSEVTKRFDLKDEVYEFSSLVQPKNARKLNPASLAEVFKHFPQLKESCDPNLADSEWRKHASLPLSHFGVTDRYALYNMKVDDYWKEVFSTLNPCGEPVFPNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKW8</accession>
    <name>E9HKW8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_330875</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732673">
        <property type="protein sequence ID" value="EFX67623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67623">
        <property type="protein sequence ID" value="EFX67623"/>
        <property type="gene ID" value="DAPPUDRAFT_330875"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330875"/>
    <dbReference type="HOGENOM" id="CLU_1788776_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX67623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="145" mass="16120" checksum="7628A72F8968C7EF" modified="2011-04-05" version="1">MRTTAADSRTKIVITLRYTLVNGAVETYVAQTNTADEQSRKEKEDQESEERNARVAAENLIVQKLKEAEQIAAEAKAAAEIANKRAETAAEDHAASLIIIKHQDAALKRRHDQEDEEIARKRLAEDNERAALRRGLGTSTTNPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLY6</accession>
    <name>E9HLY6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_261927</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732683">
        <property type="protein sequence ID" value="EFX67219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67219">
        <property type="protein sequence ID" value="EFX67219"/>
        <property type="gene ID" value="DAPPUDRAFT_261927"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_261927"/>
    <dbReference type="HOGENOM" id="CLU_057396_0_0_1"/>
    <dbReference type="InParanoid" id="E9HLY6"/>
    <dbReference type="OrthoDB" id="164615at6656"/>
    <dbReference type="PhylomeDB" id="E9HLY6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="313" mass="33175" checksum="9A9067126BE68B50" modified="2011-04-05" version="1">MNQKCPSSTAKITLASKKGYAGQMHTCRMCDSPTHVLANCPKQPRSLTNPSTISKGPIGTRSYSSVLLTNRGPVRTTVRKPQETGPIGGGQMPIAPTLDADTFPELAQRPTTSTVVVLDGAPGIQFRNPMELNLLLTPMLTLKTPTRSRTASSSGSGEVAEEIESGVAQLVELGSPTREVPVSIPGVDINSFPALSGGNDVPPAPISPGVPSIPSTIDQMDNEVVEEMDATKVVSISNPDEDISFSGGSIQPGQRPLDSQEASHVSETQESLGVPLGTPSTPIEDKTLKAMEDVRRKKAHDNKTQPSKPKFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPA8</accession>
    <name>E9HPA8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_332209</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
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    <sequence length="254" mass="29054" checksum="C3F85DFB95599CB9" modified="2011-04-05" version="1">MARNKKRDARYSKSRAVKESAKNAAKASALKRRQQKEERERLAGDQEPVIDFDTVPEAQDREEEAVAVEEPVEEPVEKPVEEPDEEPGQELVENNYLEHFEVQMPFLEFKRNVTMGLLSHALNENKNKAGRAGRMMPTIHPSAEPGAKRRKSRLSVRDDIRFTGVGLHLPIWGGERQKRNCFVEFHDENYLFEEEAPLAEVEAVYSASEESDGQASDHEPTNKECSSSSTDSDELEDTNRREGFIIDEYDDFKQ</sequence>
</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Basu M.K."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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</entry>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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    <sequence length="98" mass="10889" checksum="50FCE74B8478B560" modified="2011-04-05" version="1">MDEWQLTMKVTLEEYYQIQAQRAENKGITFIRSGEGNLSSEESTEEDSKSGEEDSTSEESGEDDSEGSELESSDGDQTEEEDVGAEETDPLQIIITLD</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="OMA" id="CHQSATE"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="PhylomeDB" id="E9HUV9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX64471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="320" mass="34484" checksum="0807D1A4932E1F0B" modified="2011-04-05" version="1">MATVDDALDAAAAAAAAATAATGRLNTVERNQLTMTTQLAGIAQQLQALLNAGGGGGGGGTGGGGAGGGGVVQRRRIDPSCLDKQHGDASLSQLRTWRNRWSDFCQLNQLITYPVSEQMAAFRMVLDPDMQQIVEVALGILPTAATSPEDVLDQINTYIRSKRNIALDRVAFEDCHQSATESFDDFYIRLCNLEDAADLCAACRDTRLTTRIMAGVRDTETKRKLLALSPFPTAQQTINICRSEESAKANEKSLAISHVQTRSHRPPWQTDGGRCGSCARLAHRTGETCPAIGKQCHNCGANNHFSPCCPKKPKVETRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9HVE5</accession>
    <name>E9HVE5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_14164</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732850">
        <property type="protein sequence ID" value="EFX64285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX64285"/>
    <dbReference type="EnsemblMetazoa" id="EFX64285">
        <property type="protein sequence ID" value="EFX64285"/>
        <property type="gene ID" value="DAPPUDRAFT_14164"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_14164"/>
    <dbReference type="eggNOG" id="KOG4228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1088062_0_0_1"/>
    <dbReference type="InParanoid" id="E9HVE5"/>
    <dbReference type="OrthoDB" id="411281at2759"/>
    <dbReference type="PhylomeDB" id="E9HVE5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042221">
        <property type="term" value="P:response to chemical"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="2">
        <location>
            <begin position="80"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="196"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX64285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="256" mass="29437" checksum="B94BAD70C356480D" modified="2011-04-05" version="1" fragment="single">EQRVEIIVMLTNVEEYNKTKCFQYWPDPDPSRNASTPEPLYVDPVAETQSNGGTTHSPSNGIFQYHYLVWKDFQAPEHATGILRFLRHLNEDYSTDRGPILIHCSAGVGRTGTLVASIDHLIQQVEEEGSVSVLNTVCDLRHQRNFLVQSLRQYIFVYRTLMEWVQFGNTEIAISNFQNALTNLRMKTEGRVKSSLEEEFDRLDQPFDDRKPMSVASSDENRANNRYETAIPFDRNRVILTPVAGRDRFSPLSESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9HW64</accession>
    <name>E9HW64_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_334682</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732896">
        <property type="protein sequence ID" value="EFX64018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64018">
        <property type="protein sequence ID" value="EFX64018"/>
        <property type="gene ID" value="DAPPUDRAFT_334682"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_334682"/>
    <dbReference type="HOGENOM" id="CLU_119700_0_0_1"/>
    <dbReference type="InParanoid" id="E9HW64"/>
    <dbReference type="PhylomeDB" id="E9HW64"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090502">
        <property type="term" value="P:RNA phosphodiester bond hydrolysis, endonucleolytic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX64018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="197" mass="21370" checksum="C2951419B7115CC4" modified="2011-04-05" version="1">MACRHRTTSLFNTLDSSAPATSIRAYTDGSKSSSQETTTCAIFIPALNKEHAWTLTKGSSIFTAEVTAIYQALKLFYVMDDCPPEAFIYSDSSSAITAISSNSLSENEAITATREIIASLKSSGTRTRLTWIPSHTGIEGNERTDRLAATECNTRDGEEVHNSLSPKEMVSIIRANWASSLAVSAERSLRLLTPLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9HX78</accession>
    <name>E9HX78_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_268051</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="353" mass="40832" checksum="18A18D88EED5FBDE" modified="2011-04-05" version="1">MDQKFSWMGWKALIGRNLNKKLKIYDEQRKVILPPPKECPELLQMLFTNCHPQSANFIKNARQYNNALAFASLGASIDVLRGRGPYCFKIYGQLYHNTYAVQYYDEEISVPPALKYAQLYFLDSAQANEQRLNNPANRSCDSALMEQLDALIRRVNPYAVMYKNMRQVAMEEDRQAAVEGRAPVVVSMVIHNDRRTQDERRYNSPAGEEIAVVFKSIDGAPPENRDIRGHLLIPRRGKVFIRIDTQKPMCDPMTYPLLFPNGDNGWDQNLKRRNLNEDQDNVSHDNQEEQEFETEVDIDPDVPVPIFDVNRRGPRSRITQCEFYSSQLSIRKGIFNAVLYGGPLFQQYVLMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733061">
        <property type="protein sequence ID" value="EFX63477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_065450_3_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="95" mass="10012" checksum="C8432D0396E519A9" modified="2011-04-05" version="1" fragment="single">EMNADGSYSFDFESADGTKVSESGNQKQVGPKPEDIGTVSKGSYSFTTPDGVVLTVNWVADENGFQATGDHLPTPPPMPEHVVKMLADLKAAGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZ02</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="44"/>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="221" mass="24423" checksum="C5E5FCB1FE1B3024" modified="2011-04-05" version="1" fragment="single">MIVSGGGVAVIFKSTISVRRHSHPTFNSFELIDCSLSLRPIAIRLLVVYRPPASSNSVFRDEFSSLLEQIALTNEKLLIVGDFNLSIRDQPDDAAQRLLDSTEAFGLSQLVTSATHEGGSILDLVFTRSSDDLVRGTSVLGFFSDHRPVLVSLSCRSPRFPSMPISFRRLRDIDPEAFVHDIERLNLITDPSDALDCLVAQYNDGLRSLIDKHAPVVTKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
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    <name>E9HZD3_DAPPU</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="2">
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        <name type="common">Water flea</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733319">
        <property type="protein sequence ID" value="EFX62897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX62897"/>
    <dbReference type="EnsemblMetazoa" id="EFX62897">
        <property type="protein sequence ID" value="EFX62897"/>
        <property type="gene ID" value="DAPPUDRAFT_119749"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_119749"/>
    <dbReference type="eggNOG" id="ENOG502QTQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004416_4_1_1"/>
    <dbReference type="InParanoid" id="E9HZD3"/>
    <dbReference type="OMA" id="THNISHA"/>
    <dbReference type="OrthoDB" id="1072875at2759"/>
    <dbReference type="PhylomeDB" id="E9HZD3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="164" mass="17400" checksum="CA2C7073CDAA6F33" modified="2011-04-05" version="1">MGIQQGLGVDENTGVLVDTAAQTAQVYGAGTLTVVDTAGASVQTGTYYKVNGLRVSLLSAGDRYHYASKVVTSSKALISSRYYSSFYDSPDIFAAYETSKSLTRVVDQTPTSNIGTAPKPVYSSGPAYPSGAPAIKLRFTRDASTKGYYSGGKYTVDKVKVDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9I3K9</accession>
    <name>E9I3K9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cu2_monooxygen domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_339668</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734615">
        <property type="protein sequence ID" value="EFX61421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX61421"/>
    <dbReference type="EnsemblMetazoa" id="EFX61421">
        <property type="protein sequence ID" value="EFX61421"/>
        <property type="gene ID" value="DAPPUDRAFT_339668"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_339668"/>
    <dbReference type="eggNOG" id="KOG3567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1726827_0_0_1"/>
    <dbReference type="InParanoid" id="E9I3K9"/>
    <dbReference type="OMA" id="IHHILIF"/>
    <dbReference type="OrthoDB" id="1156284at2759"/>
    <dbReference type="PhylomeDB" id="E9I3K9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016715">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="SSF49742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003238675" description="Cu2_monooxygen domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Cu2_monooxygen" evidence="2">
        <location>
            <begin position="33"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX61421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="152" mass="16962" checksum="0E7C21EFD1C3B1C8" modified="2011-04-05" version="1" fragment="single">MELAALFLFLSIIWQPCCNGFVVEDDKLPTREFELRMPKAEPKEPETYLCTPLKLDKQNTYYIVGFEPRAEKKTAHHMLLYGCKTPGRYDPVFNCGAMTVKQEGLNSAMNPCGSGSSIIYAWAQNAPKLKLPKDVAFRVGGPDSGIDSLVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9I3Z1</accession>
    <name>E9I3Z1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_18807</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734817">
        <property type="protein sequence ID" value="EFX61289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX61289"/>
    <dbReference type="EnsemblMetazoa" id="EFX61289">
        <property type="protein sequence ID" value="EFX61289"/>
        <property type="gene ID" value="DAPPUDRAFT_18807"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_18807"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2856252_0_0_1"/>
    <dbReference type="InParanoid" id="E9I3Z1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX61289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="65" mass="7628" checksum="1D738A9F01EB811F" modified="2011-04-05" version="1" fragment="single">AKSDIWSLGCVLYEFINLKPPFRARDMEGLYKKVTRGYYSRINKIYSDDLSNLLKSLIKVNPNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9I4X5</accession>
    <name>E9I4X5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_16242</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL735250">
        <property type="protein sequence ID" value="EFX60955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX60955"/>
    <dbReference type="EnsemblMetazoa" id="EFX60955">
        <property type="protein sequence ID" value="EFX60955"/>
        <property type="gene ID" value="DAPPUDRAFT_16242"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_16242"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020233_2_0_1"/>
    <dbReference type="InParanoid" id="E9I4X5"/>
    <dbReference type="OMA" id="ANIRWEA"/>
    <dbReference type="OrthoDB" id="533387at2759"/>
    <dbReference type="PhylomeDB" id="E9I4X5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Lucas S.M."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="non-terminal residue" evidence="2">
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        </source>
    </evidence>
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    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX90297.1"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <end position="229"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX90297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="229" mass="26635" checksum="5CB3023719F1D56D" modified="2011-04-05" version="1">MARWRLFSIALVVFATFFIIATVNAQRHHHDDSITQLLKDPERLEIVHAMLKKYKAKIMKSPLGDPANSMGPPVWVGNFPPSLPNDQEFFLEQNTNDTFINEPTKRNGHHNHRLVRSRNEPLSEEICKTNRYWKQINDTRDIYGQEVRIVHSSEYRQFAFVYECIREGEHCTGISEHLQSTCEMRPGWANMLHVKLTTVDTSLAPQWGYVAVPHHCACRIYPRVNPFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9FR14</accession>
    <name>E9FR14_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_300127</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_300127"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="V-type_ATPase_suC/d"/>
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    <dbReference type="PANTHER" id="PTHR11028">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX90268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
    <sequence length="348" mass="40147" checksum="D113E28644BD912C" modified="2011-04-05" version="1">MRFQEFNIDNGYLEGLCRGFKNGVLKQADYINLVQCETLDDLKLHLQSTDYGQFLANEPSPLAVSVIDDRLREKLVIEFQHMRNHAVEPLATFLDYITYSYMIDNIILLITGTLHHRPITELISKCHPLGSFEQMEAIHVASTPAELYNAVLVDTPLAPFFVDCISEQDLDEMNIEIIRNTLYKAYLESFYQYCQTLGGTTAEVMCEILAFEADRRALIITINSFGTELSKDDRVKLYPTCGRLHPDGLAALARADDFEQVRGIAEYYAEYKELFDGSGNNPGEKTLEDKFFEYEVKLNMYGFMQQFHFGVFYSYLKLKEQECRNIVWISECVAQKHRAKIDNYIPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9FR33</accession>
    <name>E9FR33_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX90090">
        <property type="protein sequence ID" value="EFX90090"/>
        <property type="gene ID" value="DAPPUDRAFT_94343"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_94343"/>
    <dbReference type="HOGENOM" id="CLU_1158858_0_0_1"/>
    <dbReference type="OrthoDB" id="1738727at2759"/>
    <dbReference type="PhylomeDB" id="E9FR33"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX90090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="240" mass="26546" checksum="212A73D6BF6C9AB5" modified="2011-04-05" version="1" fragment="single">NSPLTTGIRSNSRTKGGASSYSTSNDRENRIALVDLSSSVDIGQIVEEDINERMAHFYVYATKLQSLASSGRSMGLASGFLDVKALMHWSVVVKFESPESVYTLDADTSGGLTGAEFVVKVKREYPEQVQRQIFVGSVIISPRELIRRAKEVRLNEGKYDFIFANCQSWAHTFCREISPDFANNLPATIGDCTSLAATVGATVVSLGFTGMAIGWTVYKTLQYRKLKRESQDKEECEDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUV1</accession>
    <name>E9FUV1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_311160</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88857"/>
    <dbReference type="EnsemblMetazoa" id="EFX88857">
        <property type="protein sequence ID" value="EFX88857"/>
        <property type="gene ID" value="DAPPUDRAFT_311160"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_311160"/>
    <dbReference type="eggNOG" id="KOG2985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027228_1_2_1"/>
    <dbReference type="InParanoid" id="E9FUV1"/>
    <dbReference type="OMA" id="DLYAMKN"/>
    <dbReference type="OrthoDB" id="583722at2759"/>
    <dbReference type="PhylomeDB" id="E9FUV1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="74"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="177"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="273"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX88857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="467" mass="50666" checksum="F53CF33C9FCE486E" modified="2011-04-05" version="1">MDFETLNKLKSSGTVVGLGNETARPACKKCGYPGHLTFQCRNFLSTNPASGVVLDVSSTRAGGIGTIVAGEPAPVFLEPVNNVTVVIGRDISLTCAVDHLGPNKVAWIHLDRHMIVAIHQHLVTRIPRYSATHDAHRNTWTLNLRGAQPEDAGRYLCQVNSNPMITQVGIVDVVVPPAIVDAGSSASHITVREGLSLTLTCRGDGVPAPKVTWRREDGRPIFFGDKKKEASIEGDSLTLNKIGRTESGAYLCIASNGVPPSVSKRIWVDVEFPPMVWVPAQIVGLPLGGSVTFDCFTEAQPKAITYWTRMTGGPSDSDVVLLPSRRIHADSTSSGYRTHMNLTIQSFEVKDIGTYRCVAKNSLGEAEGSVQLMETEPEHSNNEMIVDVEFAKDVQSPPTTPQKTTILARSTVKPSTSTWQQGNRVQFISNNSHSTGRQSTTRNSGLSLLPRWPDVMILLAVTKLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXL8</accession>
    <name>E9FXL8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_221337</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88108">
        <property type="protein sequence ID" value="EFX88108"/>
        <property type="gene ID" value="DAPPUDRAFT_221337"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_221337"/>
    <dbReference type="eggNOG" id="ENOG502TBGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1039224_0_0_1"/>
    <dbReference type="InParanoid" id="E9FXL8"/>
    <dbReference type="OrthoDB" id="985894at2759"/>
    <dbReference type="PhylomeDB" id="E9FXL8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236924" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="160"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX88108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="282" mass="31697" checksum="E9FEF28A6ABED1B8" modified="2011-04-05" version="1">MIRVVIAFYVLAIFLVSSGHGNVVPFRDNNIFPGCEGYMFVDDEVVIEGPFNEDCVLQFETQEDRILAFSVVDGDLIETASFLSIHDGIDSKAPVLLAENQKVLEVSNKDLPTTVYTTQSEAVIRFTNKKLTSNLKLKIQKAVRCAFNLGIDSQCGRVVDEVSCYCATFVNRIHPDQTMFCVDHNMKLVSFENRTEEELVQAAWGTEVSYWTSLTDTRRDGTWLWESSMTVPADYTNWYPKRPNTAVNNVDDCMAYGGATYLNFWGDIACTTMAHAICEAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9FY90</accession>
    <name>E9FY90_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_306485</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87498"/>
    <dbReference type="EnsemblMetazoa" id="EFX87498">
        <property type="protein sequence ID" value="EFX87498"/>
        <property type="gene ID" value="DAPPUDRAFT_306485"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306485"/>
    <dbReference type="eggNOG" id="KOG0921">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1628735_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX87498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="163" mass="18421" checksum="BB317622E7B9BC02" modified="2011-04-05" version="1">MDAVHCNSVVVIRGNTGSGKNNSVFFFSILKVYRVNGNYPELDVVIGPIGIGHYPNIFAHREKRKVQMADARSRPSLIHKSSVNCPDSDEIEFPLPYFVFREKIAISMQPNARARQPVRNPNVLQTKDMTASSNLVATKLVLYLIDLPYQSKLFVMEKRIGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYA1</accession>
    <name>E9FYA1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_192128</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87810"/>
    <dbReference type="EnsemblMetazoa" id="EFX87810">
        <property type="protein sequence ID" value="EFX87810"/>
        <property type="gene ID" value="DAPPUDRAFT_192128"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_192128"/>
    <dbReference type="eggNOG" id="KOG3510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_947520_0_0_1"/>
    <dbReference type="InParanoid" id="E9FYA1"/>
    <dbReference type="OrthoDB" id="1099491at2759"/>
    <dbReference type="PhylomeDB" id="E9FYA1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="PTHR23279"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="95"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX87810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="294" mass="31853" checksum="9B0913C8E4A5CE8A" modified="2011-04-05" version="1">MESRDPASSGGRFGGGGGNHFLDDDEDDDGDGVVWPTLSLSPRFQHIPPPPPPVVYGNLHKSFDIIRTPLPPKKKKKKKSNLISFLVEIGPFFEPEFATNISVLAGQTVLLQCRVMDLGDRVVSWVRQSDLAILASGGVSHTSDNRITASADETLTDWELQIAEAQTKDSGLYECQVNTEPKINWPVTVHVEVALDSPRGGISLETERTVTGMSSKLLLTRATVQDGGNYTCAPPGAQPADVTVHVLNGKSFRVNSPPTCRLTLSLCRLAENTSLFIDGFFLCVVVGFVFFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZ96</accession>
    <name>E9FZ96_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_127266</name>
        <name evidence="12" type="ORF">DAPPUDRAFT_312297</name>
        <name evidence="11" type="ORF">DAPPUDRAFT_312334</name>
        <name evidence="10" type="ORF">DAPPUDRAFT_312394</name>
        <name evidence="5" type="ORF">DAPPUDRAFT_312397</name>
        <name evidence="7" type="ORF">DAPPUDRAFT_312593</name>
        <name evidence="6" type="ORF">DAPPUDRAFT_43976</name>
        <name evidence="8" type="ORF">DAPPUDRAFT_97288</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX86943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86943"/>
    <dbReference type="EnsemblMetazoa" id="EFX86943">
        <property type="protein sequence ID" value="EFX86943"/>
        <property type="gene ID" value="DAPPUDRAFT_312397"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87021">
        <property type="protein sequence ID" value="EFX87021"/>
        <property type="gene ID" value="DAPPUDRAFT_43976"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87071">
        <property type="protein sequence ID" value="EFX87071"/>
        <property type="gene ID" value="DAPPUDRAFT_312593"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87269">
        <property type="protein sequence ID" value="EFX87269"/>
        <property type="gene ID" value="DAPPUDRAFT_97288"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87304">
        <property type="protein sequence ID" value="EFX87304"/>
        <property type="gene ID" value="DAPPUDRAFT_127266"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87366">
        <property type="protein sequence ID" value="EFX87366"/>
        <property type="gene ID" value="DAPPUDRAFT_312394"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87397">
        <property type="protein sequence ID" value="EFX87397"/>
        <property type="gene ID" value="DAPPUDRAFT_312334"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87418">
        <property type="protein sequence ID" value="EFX87418"/>
        <property type="gene ID" value="DAPPUDRAFT_312297"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_127266"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312297"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312334"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312394"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312397"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312593"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_43976"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_97288"/>
    <dbReference type="eggNOG" id="KOG1744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075666_2_0_1"/>
    <dbReference type="OMA" id="AQLCQTT"/>
    <dbReference type="OrthoDB" id="1536672at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="Histone_H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="PTHR23428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone" evidence="4">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX86943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX87021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX87071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX87269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX87304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX87366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX87397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX87418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="123" mass="13650" checksum="B4ED23A90038D40B" modified="2011-04-05" version="1">MPPKVSGKAAKKAGKAQKNIAKGDKKKKRKRKESYAIYIYKVLKQVHPDTGISSKAMTIMNSFVNDIFERIAGESSRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9G045</accession>
    <name>E9G045_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_22257</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LIX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX86835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86835"/>
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        <property type="protein sequence ID" value="EFX86835"/>
        <property type="gene ID" value="DAPPUDRAFT_22257"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_22257"/>
    <dbReference type="eggNOG" id="ENOG502QR91">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065651_0_1_1"/>
    <dbReference type="InParanoid" id="E9G045"/>
    <dbReference type="OMA" id="VAREHES"/>
    <dbReference type="OrthoDB" id="1026341at2759"/>
    <dbReference type="PhylomeDB" id="E9G045"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029270">
        <property type="entry name" value="LIX1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14954">
        <property type="entry name" value="LIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX86835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="258" mass="28967" checksum="435CF86B108CA5CA" modified="2011-04-05" version="1" fragment="single">KTKTVLKEAVDAVVSSFAKHSQGYGRVNVVEALQEFWQMKQARGADLKNGALVIYESVPSSSPPYVCYVTLPGGSCFGSFQNCPTKAEARRSAAKIALMNSVFNEHPSRQISDDFIEKAVAEARASFKGDPDEADNPNTGIGAFRFMLEANKGRTMLEFQELMTVFQLLHWNGSLKAMRERQCSRQEVVAHYSHRALDDDMRSQMALDWIAREQETPGIVSRELNMAERELEAARLAGRELRFPKEKREILMLACSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9G0G4</accession>
    <name>E9G0G4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_235658</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87409">
        <property type="protein sequence ID" value="EFX87409"/>
        <property type="gene ID" value="DAPPUDRAFT_235658"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_235658"/>
    <dbReference type="HOGENOM" id="CLU_3070816_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX87409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="53" mass="5649" checksum="8D846100AB3DD0B5" modified="2011-04-05" version="1">MQIATSGDITLIQFPTNTVNYTVNTCDGPKADESDATTTHPNKLSGYTDATEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9G0U4</accession>
    <name>E9G0U4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_312432</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX86966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86966"/>
    <dbReference type="EnsemblMetazoa" id="EFX86966">
        <property type="protein sequence ID" value="EFX86966"/>
        <property type="gene ID" value="DAPPUDRAFT_312432"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312432"/>
    <dbReference type="eggNOG" id="KOG2117">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040467_1_1_1"/>
    <dbReference type="InParanoid" id="E9G0U4"/>
    <dbReference type="OMA" id="YRIERMV"/>
    <dbReference type="OrthoDB" id="1613087at2759"/>
    <dbReference type="PhylomeDB" id="E9G0U4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042816">
        <property type="entry name" value="Nsrp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31938">
        <property type="entry name" value="PTHR31938"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="DUF2040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2040" evidence="5">
        <location>
            <begin position="80"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="207"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="125"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX86966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="393" mass="44994" checksum="E5C0D0E34FF92679" modified="2011-04-05" version="1">MDPKNKKYGLIIPSKNKGAKDFLSNVSEMRKPNKVFGGDGSSSDDNLEEDEEDGAKALDWRSRAVAKAAEKSMQRNQARQVALKALAEDPTVFQYDEVYDEMQQKKEEKKPPKEERKPKYIGNLLKTAELRKVELERRVERKVQKERETEGDTFNDKESFVTPAYRAKLAELKKLEEEERLRELREASLDVTKQQDLSGFYRHLYKQTFSEDQPKKVEEPEEPVTFKKEAVESEVKSRRQYRSRREEEEEVDEEKEEEEPSPEQGTEQPEVPGDQNISNAEGGKSRSKEDRRPAASASLVSAAAADRGLTADRAAKKTAASDDVEKPRADIKEEDSESDDDDDEKGSIHSPPPEEVAPPPKIKIDIWKKRTTGHLLEEAIQRYLARKEAREMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9G137</accession>
    <name>E9G137_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_192973</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86706"/>
    <dbReference type="EnsemblMetazoa" id="EFX86706">
        <property type="protein sequence ID" value="EFX86706"/>
        <property type="gene ID" value="DAPPUDRAFT_192973"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_192973"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_4_0_1"/>
    <dbReference type="InParanoid" id="E9G137"/>
    <dbReference type="OMA" id="NIGHEEA"/>
    <dbReference type="OrthoDB" id="1263520at2759"/>
    <dbReference type="PhylomeDB" id="E9G137"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="COesterase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX86706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="324" mass="36140" checksum="BB39E558BDBB9C72" modified="2011-04-05" version="1">MISSSRRSFLAFRGIPYAKPPLGELRFKDPVPVDPWFGNILDASREESPCIQYNGMLQRFMGVEDCLTLNIYTHNFASEVDNPRPVMVYFHPGSFFFGSAGVTTDLAGPGYFLDRNIVLVTVQYRLGSFGFLSTEDSQAPGNYGLLDQTMALRWVRDHVLSFGGNPNSVTLFGSSAGGACVHYHLLSPHSKGLFHRAISQSGTSLNSWAIKKSVGQYTQKLAKYLNCPQLNSIELLACLREKPARQVVQFQKKIEIMQVFPVGFGPRVDVERESPFLPAEPRILMESKQINSVPVIIGTNRNEGGSMIRSKSEIPHLKFVDFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9G2K6</accession>
    <name>E9G2K6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_308530</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732530">
        <property type="protein sequence ID" value="EFX86273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86273"/>
    <dbReference type="EnsemblMetazoa" id="EFX86273">
        <property type="protein sequence ID" value="EFX86273"/>
        <property type="gene ID" value="DAPPUDRAFT_308530"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_308530"/>
    <dbReference type="eggNOG" id="KOG3655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013085_0_1_1"/>
    <dbReference type="InParanoid" id="E9G2K6"/>
    <dbReference type="OMA" id="TNIDMVD"/>
    <dbReference type="OrthoDB" id="885776at2759"/>
    <dbReference type="PhylomeDB" id="E9G2K6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="term" value="C:postsynaptic density"/>
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    </dbReference>
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    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
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    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0045773">
        <property type="term" value="P:positive regulation of axon extension"/>
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    <dbReference type="GO" id="GO:0061003">
        <property type="term" value="P:positive regulation of dendritic spine morphogenesis"/>
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        <property type="term" value="P:regulation of actin filament polymerization"/>
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        <property type="entry name" value="SH3_Abp1_eu"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ADF-H"/>
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        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR035717">
        <property type="entry name" value="Drebrin-like_SH3"/>
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        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
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    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
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        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50044"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="476"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="220"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="275"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="351"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX86273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="535" mass="60039" checksum="410A0AE001F0D87F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E9G2Q3</accession>
    <name>E9G2Q3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin-H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EOG090X080D</name>
        <name evidence="7" type="ORF">DAPPUDRAFT_193044</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TCO</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX86471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015315">
        <property type="protein sequence ID" value="SVE84934.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86471"/>
    <dbReference type="EnsemblMetazoa" id="EFX86471">
        <property type="protein sequence ID" value="EFX86471"/>
        <property type="gene ID" value="DAPPUDRAFT_193044"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_193044"/>
    <dbReference type="eggNOG" id="KOG2496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022620_0_0_1"/>
    <dbReference type="OMA" id="FRVEQNT"/>
    <dbReference type="OrthoDB" id="1469819at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070816">
        <property type="term" value="P:phosphorylation of RNA polymerase II C-terminal domain"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000079">
        <property type="term" value="P:regulation of cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027081">
        <property type="entry name" value="CyclinH/Ccl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="PTHR10026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00569">
        <property type="entry name" value="ccl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYCLIN" evidence="6">
        <location>
            <begin position="62"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX86471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="SVE84934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="328" mass="38164" checksum="DA25F5E62F467BB5" modified="2011-04-05" version="1">MFATSTQRSFWMFKDENDVSNARLSANIKYISSRGRNMTAEERELQFLNVTEEKILIMSYEYQLRDFCRKFLPPMPRYVIGTALHYLKRFYVNNSVMDYPPKEILVTCVYLACKVEEFNVSMDQFVGNLKGDREKAASIILNNELLLMQQLDYQLTVHNPFRPLEGLMIDMKTRFPTFSDPERLRSGIDEFLEQVFYTDAILIYSPSQISLAAIIHSASTSKENVDEYITKILFSEDQKRLLNLIEAVKKIRVMVRNVQTPHRDVIKALEKKLQLCCNTDNNSESPAFKKRMKQSFDDEESFEDGQYPSADSDQVRSMLMGMSEMGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6G7</accession>
    <name>E9G6G7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_99353</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Detter J.C."/>
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                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Tsuchiya D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
    <sequence length="107" mass="12282" checksum="488E22F35D84CD78" modified="2011-04-05" version="1">MDEFETIGDDLSGTVEELLNGEPTVIRPSLNLDQATWEGWFNNIILYAAQNPWDFIYYVLMCLSPFFLLSVFLSMKLAKALEAQEKDSKRKAKRDTNISKTRKTKGD</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1 3 4">Belongs to the cullin family.</text>
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        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX81447.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Pritham E.J."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="PhylomeDB" id="E9GGS9"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX81076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 4" key="1">
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_318095"/>
    </dbReference>
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    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_318095"/>
    <dbReference type="HOGENOM" id="CLU_2029009_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX80987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIC9</accession>
    <name>E9GIC9_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="4">
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732546">
        <property type="protein sequence ID" value="EFX80792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80792"/>
    <dbReference type="EnsemblMetazoa" id="EFX80792">
        <property type="protein sequence ID" value="EFX80792"/>
        <property type="gene ID" value="DAPPUDRAFT_103087"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_103087"/>
    <dbReference type="eggNOG" id="KOG2170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_748561_0_0_1"/>
    <dbReference type="OrthoDB" id="1453168at2759"/>
    <dbReference type="PhylomeDB" id="E9GIC9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030553">
        <property type="entry name" value="Torsin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="PTHR10760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF2">
        <property type="entry name" value="PTHR10760:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX80792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="370" mass="41742" checksum="B1DD3CEDFF4D4D45" modified="2011-04-05" version="1">MTSSRRKLALKTQPGDLSKALILYQPFPGKLSFGRNLALSADPVKECKPDIQQLKSQCETKTKKQYNQTCDKSDPKKLSPGNRFSLGFVVVAVVIFSLISSIIRDDDICESSNSMTIDLKLLSSELKTNLFGQELAVTTIANVLEEFQVTVEQLTVLVLLGGSGTGKTWTNHLIGNSLPEHANQATLHLGPWSSSQEIERAFKSLECCRWNFFFIEDSDYADSQQIETVLDWAVYVNQNISCSHRKIVVILTSNYGQKEFVELLLQERENSGTRWTMNLVNVQEAAGKLTSPLINAFAQRRLHFTPVPYLPLEKMQLEQCIRQDLMFKKKSAPVDVINKITQHFQFVPPQKKYFVTSGCKTVSTFVNLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJ47</accession>
    <name>E9GJ47_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_243572</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80547">
        <property type="protein sequence ID" value="EFX80547"/>
        <property type="gene ID" value="DAPPUDRAFT_243572"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_243572"/>
    <dbReference type="eggNOG" id="ENOG502T2GI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123005_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GJ47"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237508" evidence="2">
        <location>
            <begin position="21"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX80547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="190" mass="21100" checksum="F6DE7216D3736E5F" modified="2011-04-05" version="1">MKFSASAALILLVCVVYVSAYGTHRPTTHRPTHYPTRPTYRPTYRPTHRPTHRPTHRPTHRPTYRPMKNLGNSNVNINDNKNDNVNIASLLSELFDNQEDEFPCTIGDLCYDKKKTLIKSGAAAVDAKKAVEPTETLVEKSAAPAADPVVIPAPPAVDVNFDQFANFADFQEPIFADSAEFDGNDDDLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJP2</accession>
    <name>E9GJP2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotrans_gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_318789</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732548">
        <property type="protein sequence ID" value="EFX80148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80148">
        <property type="protein sequence ID" value="EFX80148"/>
        <property type="gene ID" value="DAPPUDRAFT_318789"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_318789"/>
    <dbReference type="HOGENOM" id="CLU_630483_0_0_1"/>
    <dbReference type="InParanoid" id="E9GJP2"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="PhylomeDB" id="E9GJP2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotrans_gag" evidence="3">
        <location>
            <begin position="88"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX80148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="435" mass="49443" checksum="657B6BCAD6677E5F" modified="2011-04-05" version="1">MTSTPPTPPTAPIQIPLNQQQGPRAPSPDPSNVPLTKSHLRELYSRDERKSIPVYKGKRGDQLINNWLKDAERVAQSAGWRATDKIKYFSDRLRGDAADWHSDYIDHAADKEDYDAWEKALISRFLTETEIENLKKQLNELKQAPDQSTQTYVSRLNHLYDIIHRKEIVLDEAIAPPEAIVLARSLRKIRGEAKQKILLKGLLPKIVQVVWTRIDVNSSYEDVCEIVYAAETIANRMEQNEEKSLKAKTAGISSHEDEQDVELQRQKNKLTKLEKQLAANVAQLMRIPVTFSNLKTQALIDTSAAASFLAHRLLICIPYNDIKELQVKNYKFQTQTYSYLEQFQNRIPAPRKAVFGEHDDTIIASKPKSVTRVTKVNKPDAPQQDVFEDITASQVVSVLGDPLLTSTQKVHEELRHEHDQDAQPLGTESDSEDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9GL35</accession>
    <name>E9GL35_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_304367</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
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                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000647">
        <property type="entry name" value="CTF/NFI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020604">
        <property type="entry name" value="CTF/NFI_DNA-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019548">
        <property type="entry name" value="CTF/NFI_DNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492">
        <property type="entry name" value="PTHR11492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10524">
        <property type="entry name" value="NfI_DNAbd_pre-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51080">
        <property type="entry name" value="CTF_NFI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CTF/NF-I" evidence="9">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX79415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="182" mass="21458" checksum="6089374AA8F1A235" modified="2011-04-05" version="1" fragment="single">QDEFHPFIEALLPHVKSFSYTWFNLQAAKRKYFKKHEKRMSLEEERRCKEELQNEKPEVKQKWASRLLGKLRKDITQECREDFVLSITGKKPAMCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKAIPLESTDGERLEKSPDCLHPGLCVNPYHINVSVRELDLYLANFINSHGIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9GMD2</accession>
    <name>E9GMD2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_304835</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79345"/>
    <dbReference type="EnsemblMetazoa" id="EFX79345">
        <property type="protein sequence ID" value="EFX79345"/>
        <property type="gene ID" value="DAPPUDRAFT_304835"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304835"/>
    <dbReference type="eggNOG" id="KOG4051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080546_0_1_1"/>
    <dbReference type="InParanoid" id="E9GMD2"/>
    <dbReference type="OMA" id="PPAMHEE"/>
    <dbReference type="OrthoDB" id="1476852at2759"/>
    <dbReference type="PhylomeDB" id="E9GMD2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016573">
        <property type="term" value="P:histone acetylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="PTHR13581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX79345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="167" mass="19079" checksum="D7343F101E8B5386" modified="2011-04-05" version="1">MAVKEKTEGNEETLEAAEVEWGTVDNELQLLQILCGTRPIGISKYFQMACIVEKLAMNLNKEVTSKGVWDHLTSLYDLKKLDEHETIPFPNEEMDFVLSTEEYGELMDSKFKDAESKKVIKKEKEEVKKEKVPETPQPIEKKAVKRTRASTAPSPGTPQITPKRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9GME4</accession>
    <name>E9GME4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_245030</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732552">
        <property type="protein sequence ID" value="EFX79406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79406">
        <property type="protein sequence ID" value="EFX79406"/>
        <property type="gene ID" value="DAPPUDRAFT_245030"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_245030"/>
    <dbReference type="HOGENOM" id="CLU_1305987_0_0_1"/>
    <dbReference type="InParanoid" id="E9GME4"/>
    <dbReference type="OrthoDB" id="11810at6657"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042421">
        <property type="entry name" value="C3orf33-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28434">
        <property type="entry name" value="PTHR28434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX79406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="211" mass="24359" checksum="A09907C1AF7DB61C" modified="2011-04-05" version="1">MITNNSLSWTQYSVYAVGLIGLAVVAKSIHIFTPSKTVPREFVTRAVKLQGKVKGIEFPPVKHQQEQQPLYAVRLHVEHIPIVNLWTRPKQSDKLLEKSASSLLKIELVGVNLTTLDGANKWINSPLESNPAIWFRLYGVDSNTNLFYASVLLHRPWWKFWRQRDLSLIVLKHNEGVVASYLPSQQVYFNNKYPAYYRKLLYCAIKNKNHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9GN59</accession>
    <name>E9GN59_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_304991</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="5 6">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
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        <text evidence="6">Component of the TIM22 complex.</text>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
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            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <text evidence="6">Belongs to the Tim17/Tim22/Tim23 family.</text>
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        <property type="project" value="UniProtKB-UniRule"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="183" mass="19681" checksum="BF1EE5C66EC311C6" modified="2011-04-05" version="1">MDESTTSPAGFSPYEMDSLMKYFVGNNCKYREQIIIPRTVGPIHIKSIDEKRVEAAFESCAFKSLVASVMGYGLGAALGLFSASVSPNITAPDAPQQTAKEIFRDLKFSTLSYAKNFALVGLMFSAVECTIESYRGKADWKNGTYAGGITGGLIGLRAGLKPGIVGALGFAAFSTAIDYYMRH</sequence>
</entry>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DAPPUDRAFT_245650</name>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="entry name" value="ZCWPW1/ZCWPW2"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="132" mass="14992" checksum="BE957A16EC053F7C" modified="2011-04-05" version="1">MLFKRDTRSKTKTIKAPAYLEHLVVQLTQKTAKKKRKLSSDLRSSWKLRGAVGSADENSDGISDETGHIATLTDHATYARSLGFPEPFPEYVFHLEEAEVQKRLNRSLTVSLWIHMFQQLLKLALSRVVGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
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    <name>E9GPN2_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX78556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX78556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="167" mass="17569" checksum="6A0C184F3669FA57" modified="2011-04-05" version="1">MFAIPGTSSDPVTSKLLALISRHANPGTHPSPPASKSHTPTPKATSKQPTASRKKTAASKEDDVQSLNVPALLSPISSKPTKDKVLVRPKSVTKSHSQGLDEVAAAETERTLKLILEGCDEKETGATPAKTSNPGKKSVFNPPSKDLVGAASPNHLFQGDIARVMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPY6</accession>
    <name>E9GPY6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_320477</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Bork P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="150" mass="16999" checksum="C35C6EBD30BBD156" modified="2011-04-05" version="1" fragment="single">SQRSLVEKLELYESLYSWLYNVNIDTLSTENERKLFIEEVDSNISALMISIYPLCPSKWDKHEPAAILLNQLMQKRMNPQQAEVIDAVLTGKDCLAVMPTGGGKSACYFIPGLLQIGVKATCDPFENEDLVMKFFMNNFRRDIGNSSVKL</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    <sequence length="245" mass="26930" checksum="08749184B581CDF9" modified="2011-04-05" version="1">MKLLVVLGLIVAIASATPIDQDDKVEELTVVSMPDKGEPAVEERQVISNLANLVGSANVADLTAIIQQLVREELKNILANLQNAQNLTTTTLSGLINADESNSEKLQQVVVKQEVDKQAEAKPVYFLPRRPGYFPPQHPMYYGPQQAVPYYNEEPYFYRGGPQWRRINPTDETLSDMDALAELELLLNEKGEMSSEARGLMSSLSSTTNSAKASFKSFVNNLSSALPSFSIVRKTYLVPGLAING</sequence>
</entry>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dimer_Tnp_hAT" evidence="1">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="183" mass="21466" checksum="219658E0C3645315" modified="2011-04-05" version="1">MDLEVHVLWVEGIRQKIDSLAFWKNQRHRFPYLSKLAFTLLALQASSAPSEREFSIAGWHCAGRKNRTDKDNLAAKSTERLFRFFPRQELHRTQYEETPLLWAVENVASYHITISKFLQMEPIDMKDAQGSTKHRLVFEQNFNPQLDEQFINNDHSVRPFPVFRPAESLFSSNTLGFLKISWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZ94</accession>
    <name>E9GZ94_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FtsJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_306870</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
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                <person name="Tu H."/>
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                <person name="Wang M."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732577">
        <property type="protein sequence ID" value="EFX75196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75196"/>
    <dbReference type="EnsemblMetazoa" id="EFX75196">
        <property type="protein sequence ID" value="EFX75196"/>
        <property type="gene ID" value="DAPPUDRAFT_306870"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306870"/>
    <dbReference type="eggNOG" id="KOG4589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_4_2_1"/>
    <dbReference type="InParanoid" id="E9GZ94"/>
    <dbReference type="OMA" id="HRQTDHL"/>
    <dbReference type="OrthoDB" id="1039414at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FtsJ" evidence="4">
        <location>
            <begin position="53"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX75196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="242" mass="26850" checksum="4AB7BC1E05178232" modified="2011-04-05" version="1">MNIAVCSVRQFCSSSTCFKKVPDRLKGRSKSSQEWLTRQMNDEYVLKAKMENYRARSAFKLIEIDDKHKFLKPGDVVVECGAAPGAWTQVCVKRINATGKVSSQLKGKHVAVDLQPMYPIEGAVILAPLDFTKSLSQTRITEILGGQLANAVLSDMAPAASGIRDLDQDRILELAYSVLRYAQQISMDGATLLIKLWAGGRIKQLENEIALHYSQVKVVKPPSSRQDSAEMFILASNFKKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZG3</accession>
    <name>E9GZG3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_199569</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732577">
        <property type="protein sequence ID" value="EFX75163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75163"/>
    <dbReference type="EnsemblMetazoa" id="EFX75163">
        <property type="protein sequence ID" value="EFX75163"/>
        <property type="gene ID" value="DAPPUDRAFT_199569"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_199569"/>
    <dbReference type="eggNOG" id="KOG1804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001451_0_0_1"/>
    <dbReference type="InParanoid" id="E9GZG3"/>
    <dbReference type="OMA" id="FCEWHLA"/>
    <dbReference type="OrthoDB" id="286011at2759"/>
    <dbReference type="PhylomeDB" id="E9GZG3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:post-transcriptional gene silencing by RNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="SSF90229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="974"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="976"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX75163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1057" mass="120447" checksum="FB0440DAA591777A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZL8</accession>
    <name>E9GZL8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_323732</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CLCR family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732578">
        <property type="protein sequence ID" value="EFX75018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75018">
        <property type="protein sequence ID" value="EFX75018"/>
        <property type="gene ID" value="DAPPUDRAFT_323732"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_323732"/>
    <dbReference type="eggNOG" id="ENOG502QRRD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005812_0_0_1"/>
    <dbReference type="InParanoid" id="E9GZL8"/>
    <dbReference type="OMA" id="NSEAPNM"/>
    <dbReference type="OrthoDB" id="685640at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013642">
        <property type="entry name" value="CLCA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWFA"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237607" description="VWFA domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="302"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX75018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="923" mass="102222" checksum="A9F6D3D766C726FB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
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    <name>E9H046_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_251296</name>
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        <name type="common">Water flea</name>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX74928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_251296"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_251296"/>
    <dbReference type="HOGENOM" id="CLU_1887842_0_0_1"/>
    <dbReference type="InParanoid" id="E9H046"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="135" mass="15368" checksum="D32D606B363AFF9F" modified="2011-04-05" version="1">MKRLVDLRRRVVKDLCPGELVLVRRKLKKKNKTKKLLPKYVGPYQVVKKLRYNVVQICKFHPREDPEWDDWPDEPDDRMPDDPDGSLVQQAAEEDDVVAPSSAISPIDPPNEKQGNGKGRHNSSSSSSSSSSFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2E2</accession>
    <name>E9H2E2_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_252276</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX74161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1236183_0_0_1"/>
    <dbReference type="OrthoDB" id="1739457at2759"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="122"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="224" mass="25758" checksum="56C80C7549B5F5F4" modified="2011-04-05" version="1">MSTPVIGDSAQVKLTEISNYLDIQNGVNMVWPTGIPNQQANEQTSYLVVPPIQETSRQVQFHQFVNWRPGQPLNYNSSSHQYFAAAYTRSPNYVMTDPRRIQGMETTIEYLRELLTKEFSNNVKEKTMKEEMKKELEELIEKNKFLQEQLQTAVVSIKELESERKEINCVLEDVLDAQKTLAANHKELLDAQSELVVAQNNISELNTLLEFKFSLFLALDSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9H3H4</accession>
    <name>E9H3H4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX73787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73787">
        <property type="protein sequence ID" value="EFX73787"/>
        <property type="gene ID" value="DAPPUDRAFT_109566"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_109566"/>
    <dbReference type="eggNOG" id="ENOG502S2U8">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="E9H3H4"/>
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    <dbReference type="PhylomeDB" id="E9H3H4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX73787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="492" mass="55886" checksum="B99DBEFF72E17B5E" modified="2011-04-05" version="1">MALGSDLAICYRQLCLDNIKTYFESSNDSVADFLEIQNFKKQSEKCIIAEDIEIGDNPFHYLPTVLLEEIIKVLSHDLKKPMMKTILEHLITPQITTLKLSYYEEDYLKHVPKFRKLEKLNISLNSSLGDSCFKLIGTYCKSLRELNASGCHGMTDSAIQWLCVEAKNQRMENETLGQCKRIEKLRITRTQVTVKGVQLALKHLPALKILHHEATVTALANMTTFSYKNAQVFRKYPLLALFIALGTPYTSGSLNQAVSMCPRIDNIRICANNEGLTDNDLFCLKSIQTLRELAIFLVPNVKENLKFTFGGGVAPLLELVGNSLEKLNLSVFDADDVWIITEFCPNLRSLILLKNLKSTAISSQEEKINHQFQTERSRKKGPILKKLVYLCIGYLNFPFDILIYLLSFPSLLDVRIHHCATLTDVVFEEVARIHQFRNLERLILICCCSITYDGIDILMVDGIETEIFVATAWTSSEQDSAITCSRKTRTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9H548</accession>
    <name>E9H548_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_110077</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX73140.1"/>
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    </dbReference>
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        <property type="protein sequence ID" value="EFX73140"/>
        <property type="gene ID" value="DAPPUDRAFT_110077"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502TFSH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="PhylomeDB" id="E9H548"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX73140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="278" mass="29913" checksum="DD198BCD00DC8BFE" modified="2011-04-05" version="1">MFAEGXSLWEALAAIRSTPVSGSLPAPSVLLQGRNLRGVLPFLDASLSPKLVPASFVRQELSRRQQTAAFVQPRPVSVRSSALTVGQRVRALIKGTWQLGVVNVVCPEPHSYIVRLTDGRMFRRTRWAINVDNANRPTAVQRTMQPSRPQFSRGPAVVPLTQPPALVQPSGNSAVAVQSAVTRTARPVAGVNTPSGQSSVFQSSAQQESTPVRSVEAPSRPVREIPASPARLFVSRIPVRDRVVWLPPSASTGQHAPVAALGVTRSGRRYIKPPPSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5H7</accession>
    <name>E9H5H7_DAPPU</name>
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        <recommendedName>
            <fullName evidence="6">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_253818</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Cladocera</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_253818"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:chemical synaptic transmission"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
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            <end position="59"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <sequence length="357" mass="40230" checksum="3E7179E147A37EC0" modified="2011-04-05" version="1">MSSAEQGKIDNSHNQTYCSNINQFDEVVPVVLPPVLFVFRTMAVTFGIPIQLLVAVVILKTRQLHTPRNAFWLGNITSHFAILLMGIFEYWAVIISTTNPLSCRIYFLLAGTPYTSLLMSLLLATADRWFAISNPIKHRKYVTVAGVAGCLVVSWLLVFFILTSPYWSGEVPFPGPCKGLSLNPQVTKWVTLSHFVLAVLIIAAQISVYVKTRQYLRFRVQHEMAGDLNRTSNNSTFNSHPDEYFVHLPDKTICRLELEASVTLLCGVVSLMACALPLAFVFLTLIVCKIGFEALQCDLATILTFIPYAREMLLLHSVISPLLYILRSREFAKALRRKLPFCFRPLRTDSPIELQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX72795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="FN3_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003238056" evidence="3">
        <location>
            <begin position="26"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1446"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX72795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1509" mass="168827" checksum="EA91A433564183B5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9H644</accession>
    <name>E9H644_DAPPU</name>
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        <recommendedName>
            <fullName evidence="5">Procollagen-proline 4-dioxygenase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DAPPUDRAFT_308081</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX72791"/>
        <property type="gene ID" value="DAPPUDRAFT_308081"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_308081"/>
    <dbReference type="eggNOG" id="KOG1591">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0018401">
        <property type="term" value="P:peptidyl-proline hydroxylation to 4-hydroxy-L-proline"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
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        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="Pro_4_hyd_alph_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PTHR10869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240866" description="Procollagen-proline 4-dioxygenase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="561"/>
        </location>
    </feature>
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        <location>
            <begin position="426"/>
            <end position="539"/>
        </location>
    </feature>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="561" mass="63520" checksum="B55C6197B09A80EF" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6B4</accession>
    <name>E9H6B4_DAPPU</name>
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        <recommendedName>
            <fullName evidence="1">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX72625">
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        <property type="gene ID" value="DAPPUDRAFT_215844"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_215844"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6G4</accession>
    <name>E9H6G4_DAPPU</name>
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        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
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    <gene>
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    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Wang M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
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        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732601">
        <property type="protein sequence ID" value="EFX72244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72244"/>
    <dbReference type="EnsemblMetazoa" id="EFX72244">
        <property type="protein sequence ID" value="EFX72244"/>
        <property type="gene ID" value="DAPPUDRAFT_59294"/>
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    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_59294"/>
    <dbReference type="eggNOG" id="KOG4309">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
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        <property type="entry name" value="Mediator_Med20"/>
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        <property type="entry name" value="PTHR12465"/>
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    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
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    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019690"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX72244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="218" mass="23726" checksum="05B43194EB2A2C11" modified="2011-04-05" version="1">MLFFNFSLQLFAVPEGKSGPQVIEMLTKRAIALGAVLSGSFIVDCETYSSTASLGAPRSVHLLHNSETPASVFALLEAASGNKTVALVADNLFDLLMLKLSNFYTAKKQTKIESRGPRFEAGDFLVKLGSVTMGPAFKGILVEVEYQACSLPAACWDLIREFMQGFLGGCVPSTPPPYIQVCSFFLLPSRFGDMLGTIDGINQYLEQFNAFRKTTGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCJ6</accession>
    <name>E9HCJ6_DAPPU</name>
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        <recommendedName>
            <fullName evidence="1">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">DAPPUDRAFT_256946</name>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX70483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70483">
        <property type="protein sequence ID" value="EFX70483"/>
        <property type="gene ID" value="DAPPUDRAFT_256946"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_256946"/>
    <dbReference type="HOGENOM" id="CLU_2294476_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
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        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="52"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="101" mass="11648" checksum="105EBAE486FE5F6F" modified="2011-04-05" version="1">MFNIDVVQDSGLTDVVLHALLVIDVLATREVLGLIPNVFSAVFLKARDLASFAPENFTGKKRWSSLFVEMEGFCRTYFVETTWEHHSNMDCVRLISQYYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCR2</accession>
    <name>E9HCR2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_328285</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732621">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70471"/>
    <dbReference type="EnsemblMetazoa" id="EFX70471">
        <property type="protein sequence ID" value="EFX70471"/>
        <property type="gene ID" value="DAPPUDRAFT_328285"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_328285"/>
    <dbReference type="eggNOG" id="ENOG502QUPX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084309_1_0_1"/>
    <dbReference type="InParanoid" id="E9HCR2"/>
    <dbReference type="OMA" id="QKENAMF"/>
    <dbReference type="OrthoDB" id="1403784at2759"/>
    <dbReference type="PhylomeDB" id="E9HCR2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="PTHR15367"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000777">
        <property type="entry name" value="RNA_polIII_C31"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX70471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="208" mass="23734" checksum="CB078FC43B50D962" modified="2011-04-05" version="1">MGGRGRGRGNAVSFNIEQLGFGRGEAGPVSVTQPPPLFPSLENRPLPLIKDVENEYILVTQKDLSTRMRNSPFYLKKSENPSYEKELPVLWNRMPAELRETLPKRLATGNSKVTLNAKKKKVEDPDKIFAKLEKKERNESEVEEDGDGKEDEDDQDKSDDEKVENEDDVEEDLDEEMDDHTDYANNYFENGEAYLEDEEGQDDGEAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9HD35</accession>
    <name>E9HD35_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_328154</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732622">
        <property type="protein sequence ID" value="EFX70358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70358">
        <property type="protein sequence ID" value="EFX70358"/>
        <property type="gene ID" value="DAPPUDRAFT_328154"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1449085_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX70358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="187" mass="20375" checksum="E5AD9B4F7D14D1C9" modified="2011-04-05" version="1">MLSALLLQLNCVALRLNVPRSALNRIRPAQERPQQEQEVDPSTRGGAPSSFGPSSTPSEIFAPSRDAIERPVERPVERPARQQPVQRPARPSAGSSAERPQRQPEFTGGFPSGFTSGLPSFDFQGRMPEPDSKSEGFMDSALNDFPNLKALGGFDAFPEAGREAEAPAKRPAQNRPARPSAQVRKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9HD86</accession>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732622">
        <property type="protein sequence ID" value="EFX70321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70321">
        <property type="protein sequence ID" value="EFX70321"/>
        <property type="gene ID" value="DAPPUDRAFT_257278"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_257278"/>
    <dbReference type="HOGENOM" id="CLU_068539_0_0_1"/>
    <dbReference type="InParanoid" id="E9HD86"/>
    <dbReference type="OrthoDB" id="155962at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="143"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX70321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="296" mass="33607" checksum="EB2CF66A606D6C7A" modified="2011-04-05" version="1">MKISVENLSSELKGSKQELAKIKTNIELEKKENKEELAKTRADFSKSVSELSTDLNVNSQSFRQELKVANDNLRKELKEELRARTRIIVDIGEMPTSCEDLQRMGHKLSGFFLVKGSMKMEAVYCNFYPNGKDLQKKIGYADVKSTPVYFYVQRRAHYETHWFTSTGTPITYELTQVNEGNAMDLSSGKFTAPRQGIYFFSFTALSRLPSSSKLVHFSVSLYLNGRSIGLAFAEEYYTLDGQNEQVTIQSTLKLAKGDKVWAQISSMSQGVKLTDYDGQYTHFTGFMLEEEIVASF</sequence>
</entry>
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    <accession>E9HDF3</accession>
    <name>E9HDF3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="4">
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        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732623">
        <property type="protein sequence ID" value="EFX70243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70243">
        <property type="protein sequence ID" value="EFX70243"/>
        <property type="gene ID" value="DAPPUDRAFT_61512"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_61512"/>
    <dbReference type="HOGENOM" id="CLU_139363_0_0_1"/>
    <dbReference type="InParanoid" id="E9HDF3"/>
    <dbReference type="OMA" id="EREFFRY"/>
    <dbReference type="OrthoDB" id="1177410at2759"/>
    <dbReference type="PhylomeDB" id="E9HDF3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="54"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX70243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="161" mass="18721" checksum="4D7A0D92B9C3E746" modified="2011-04-05" version="1">MVTINRRNFYFFLLFFKFSVFFFFFFFFVVFFSFLGVNCLQITDFSVPLAAKVGEDRQLSCQYQLGSNETLYFLRWYKDGNEFFRYMPKETPAQRVYNVSGVRIKTLSSTSTNVVLTKVEASTSGLYRCEVSAEAPGFETADREAHFNVIGKSLAFMQTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HEY6</accession>
    <name>E9HEY6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_113415</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732632">
        <property type="protein sequence ID" value="EFX69704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX69704"/>
        <property type="gene ID" value="DAPPUDRAFT_113415"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_113415"/>
    <dbReference type="HOGENOM" id="CLU_827063_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX69704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="336" mass="36003" checksum="60C251B63F6A50D6" modified="2011-04-05" version="1">MIAIKGSEDELAVNKSHATGLDPSSISNNEQSWVHSTHTTNCCCCNKRVLRGCLDGGCSSVVISREEPRPRTHTRRPALVCAKGSLLCAPTTAVSSQKEKSIWNINNNKTPTHTFSATADFRDSTSPASSECRMSSGVILNGGCAAESFTLGTVEGHREDPSGETYDECWEPEDLVATVQFLATLDDRLHVMPSSSPDEPDPVVVLSPFCPNDNSNNSTNNIISTEENDEADVGNLGGTMDTTSSSVEVEANEPLLLPSSTTLHSFGDASAPSVALSDITAEENSVSSAAQTPSSIEERSIIRTSNKPAHLKRYGTFGQDLFSRRNIYTTRAIDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9HFW4</accession>
    <name>E9HFW4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_329178</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ECSIT family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX69389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69389"/>
    <dbReference type="EnsemblMetazoa" id="EFX69389">
        <property type="protein sequence ID" value="EFX69389"/>
        <property type="gene ID" value="DAPPUDRAFT_329178"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_329178"/>
    <dbReference type="eggNOG" id="KOG3941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046917_1_0_1"/>
    <dbReference type="InParanoid" id="E9HFW4"/>
    <dbReference type="OMA" id="FGQHNVH"/>
    <dbReference type="OrthoDB" id="995360at2759"/>
    <dbReference type="PhylomeDB" id="E9HFW4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029342">
        <property type="entry name" value="ECIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010418">
        <property type="entry name" value="ECSIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113">
        <property type="entry name" value="PTHR13113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06239">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
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        <location>
            <begin position="244"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019998"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX69389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="401" mass="45956" checksum="18A8754BD84759D2" modified="2011-04-05" version="1">MAVKFGLSLNRILQRALPQVHNCKLLPCLQSRHIHINSLHFKNKEPNELIVSPSMFYVPEGDRNKDTFLEAVKIYTTRPGPRRAQVEFIYAALKEMEEFGVHRDLEAYKDIIDILPKGKYIPTNMFQAEFMHYPKQQQCIIDVLEQMENNGVCPDKETDQMVLNIFGRHGAPTKKLRRMAYWMPKFKNQSPWALPQKIPNSNLEIAKLAVQRMGSVDPATEMNIFQTSELQDAIDDTWIVNGQSANQRDLLAKLKEKQTVYVEGAFTIWLRRTSINYFILRSEPVPLTEEEQKQRNEYDYDDVSELRSWMFGEENLTRKDIVVQPSVHEQEDGTILAIAITGTCSKDSLLSWIRFLEKTNPNLANLSILFATNSPLGEVAPAIESNMPSQPLNKITGGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HG96</accession>
    <name>E9HG96_DAPPU</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_258911"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_258911"/>
    <dbReference type="HOGENOM" id="CLU_2514924_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX69239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="85" mass="9953" checksum="6BA9BB61F48353B6" modified="2011-04-05" version="1">MYCITVLISLMRCLPSRHRLFGYLLKSVKLLLKIFFHKLNKRPCRLYWMDQFTFSVVSLLEKAVILTSPPYSAWGALEKFPPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGK6</accession>
    <name>E9HGK6_DAPPU</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
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    <organism evidence="2">
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        <name type="common">Water flea</name>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732642">
        <property type="protein sequence ID" value="EFX69101.1"/>
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</entry>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
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                <person name="Arnold G.J."/>
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                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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        </location>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732660">
        <property type="protein sequence ID" value="EFX68199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68199">
        <property type="protein sequence ID" value="EFX68199"/>
        <property type="gene ID" value="DAPPUDRAFT_330328"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330328"/>
    <dbReference type="HOGENOM" id="CLU_2529700_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="84" mass="9258" checksum="DBDBACB1F39C7764" modified="2011-04-05" version="1">MSLEKSLNLDNEESPVGVVRLLKQMSEPSDFNSSINNVQSGVVISRQSSSKSLGHSSTADSSFDSISPEPLRIRKEKKHIVLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJF0</accession>
    <name>E9HJF0_DAPPU</name>
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        <recommendedName>
            <fullName evidence="3">Retrotrans_gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_330443</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732662">
        <property type="protein sequence ID" value="EFX68112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68112">
        <property type="protein sequence ID" value="EFX68112"/>
        <property type="gene ID" value="DAPPUDRAFT_330443"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330443"/>
    <dbReference type="HOGENOM" id="CLU_083426_0_0_1"/>
    <dbReference type="InParanoid" id="E9HJF0"/>
    <dbReference type="PhylomeDB" id="E9HJF0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotrans_gag" evidence="3">
        <location>
            <begin position="88"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX68112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="286" mass="32685" checksum="73C429C1E9D088E2" modified="2011-04-05" version="1">MTSTPPTPPTAPIQNPLNQRQGPRAPSPDPNNVPLTKGHLRELYSQDERKSIPVYKGKRGDQLINNWLKDAKRVAQSAGWNAKDKIKYFSDRLRGDAADWHSDYIDHAADKEDYDAWEKAIISRFLTETEIESLKKQLNELKQKPDQSTQTYVSRLNHLYDIIHGKEIVLDETIAPPEAVVLARSLRKIRGEAKQKILLKGLLPKIVQAVWTRINVNSHYEDVCEIVYAAETIVNRMEQNEEKSLKATIAGISSHEDEQDVELQRQKNKLTKLEKQLAGLNIEQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJW8</accession>
    <name>E9HJW8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_330551</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732665">
        <property type="protein sequence ID" value="EFX67969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67969">
        <property type="protein sequence ID" value="EFX67969"/>
        <property type="gene ID" value="DAPPUDRAFT_330551"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330551"/>
    <dbReference type="HOGENOM" id="CLU_076978_0_0_1"/>
    <dbReference type="InParanoid" id="E9HJW8"/>
    <dbReference type="OrthoDB" id="1593743at2759"/>
    <dbReference type="PhylomeDB" id="E9HJW8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="SSF57756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX67969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="346" mass="37091" checksum="29CF8045FF1C2EF5" modified="2011-04-05" version="1">MALPQNLIDALTNLSTAMVQDRTAAQTQSTALLNALNMQRLQSQNLVQQLANNAAAPAAATPRVAAAAVESIPCFEGKLMDFSQDFIDFVDRVAVAEGWTDAQRIQVAARRLLKTALDWHIHTGHTHATWADWPGAFTTNFSPRLHVSEWLRLVEERRQKVDESGIEYALDKHKLLRVAPIPLNEEKMVAFLIDGLASWQHVADMTANRPDHVAEFIQRIRALETLGVASRVFPPPVAPLVAPPVAPPAATPGTTTTPPVPDLNATLTAFGNQLVNQLTAQFNKMAIGSRGAGSGGGGGDRGGRSGGDRGGGGWVDPSKRKCYNCGVIGHISRHCPTKTGKDPTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HK26</accession>
    <name>E9HK26_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_330601</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732666">
        <property type="protein sequence ID" value="EFX67920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67920">
        <property type="protein sequence ID" value="EFX67920"/>
        <property type="gene ID" value="DAPPUDRAFT_330601"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330601"/>
    <dbReference type="HOGENOM" id="CLU_1300783_0_0_1"/>
    <dbReference type="OrthoDB" id="1911501at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="212" mass="24158" checksum="498A8262F86E106D" modified="2011-04-05" version="1">MPSHKCILEQDFKAVKIGMKKQLESYKKRHDTEKPGAQELNSNSEPMEVMYSLIELEEDSEPIEATTSFIVSNEDVTTLPVAEANNLVVLPIENLDISKEETETVVSLENNERQTITNSNVAVKLSKLKDDVVNLSANQLDEKVKHLTYGYAGTAARFIYYERLHKLEKKNHFRRAHHKLTDSHINPTNFEKMNVAKAAQLLSDTVAHNIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKA4</accession>
    <name>E9HKA4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_115121</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TRM44 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="9"/>
    <dbReference type="EMBL" id="GL732667">
        <property type="protein sequence ID" value="EFX67869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67869"/>
    <dbReference type="EnsemblMetazoa" id="EFX67869">
        <property type="protein sequence ID" value="EFX67869"/>
        <property type="gene ID" value="DAPPUDRAFT_115121"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_115121"/>
    <dbReference type="HOGENOM" id="CLU_021025_0_0_1"/>
    <dbReference type="InParanoid" id="E9HKA4"/>
    <dbReference type="OrthoDB" id="1146281at2759"/>
    <dbReference type="PhylomeDB" id="E9HKA4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016300">
        <property type="term" value="F:tRNA (uracil) methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="PTHR21210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX67869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="268" mass="31289" checksum="F1B31F393E1560E4" modified="2011-04-05" version="1">MALQSSIKRQPERLPTRYWVLPCCPFSFWGKFQREKFNAANSSRYFEYLRFVGEIGRNCGYQVEEDRMRIPSTRRTCFVGSIQTKSESEWAELFKAKSSMIALSKEGVEETKFQPRSAVELIRNCTRVERSIQDSFINLTAKCLLDCGTRNQPGEWNPGGEINLTDLVTLVRQDFKDFDQLKSECGGIQTLLRNHSHIFVVQNKCVRFRSPKELSVEEWRNQQKHTKATKRSRLDTAARTDVKTRICWFFVNHPDGCPLNQDLCRYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HM86</accession>
    <name>E9HM86_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_331355</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732685">
        <property type="protein sequence ID" value="EFX67147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67147">
        <property type="protein sequence ID" value="EFX67147"/>
        <property type="gene ID" value="DAPPUDRAFT_331355"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_331355"/>
    <dbReference type="HOGENOM" id="CLU_2656963_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="76" mass="8683" checksum="AD81FD0D22014CF3" modified="2011-04-05" version="1">MLSTKSLELKENLSKRKSEVDKCTIPPSKEPRIETETDKGKEEVANSFNTYQYWKDPLPDISIELGTNIANPREAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E9HND9</accession>
    <name>E9HND9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_8207</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX66535.1"/>
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        <property type="gene ID" value="DAPPUDRAFT_17267"/>
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    <dbReference type="eggNOG" id="KOG4222">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_145026_0_1_1"/>
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    <dbReference type="OMA" id="GEAMSHN"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
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        <property type="term" value="P:cell-cell adhesion"/>
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        <property type="project" value="GO_Central"/>
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    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_sub"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
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    </dbReference>
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        <property type="entry name" value="IGc2"/>
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    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
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        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX66535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="118" mass="12842" checksum="B9BD62AC9EAE4070" modified="2011-04-05" version="1" fragment="single">PRITEHPTDMTVARNDPVTLKCSADGSPAPTIEWYRDGELIVSSNGQQQQHSKSGGGGGNSHRVMLPGGDLFFFRVVHGRKESDAGLYWCLARNPQGSSRSRNATLTVACKCNVESHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9HQA4</accession>
    <name>E9HQA4_DAPPU</name>
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        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_116719</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732716">
        <property type="protein sequence ID" value="EFX66088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66088">
        <property type="protein sequence ID" value="EFX66088"/>
        <property type="gene ID" value="DAPPUDRAFT_116719"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_116719"/>
    <dbReference type="HOGENOM" id="CLU_1798399_0_0_1"/>
    <dbReference type="InParanoid" id="E9HQA4"/>
    <dbReference type="OrthoDB" id="1306247at2759"/>
    <dbReference type="PhylomeDB" id="E9HQA4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
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        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54160"/>
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    </dbReference>
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        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX66088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="144" mass="16580" checksum="CC39840187812A9C" modified="2011-04-05" version="1">MYLVKLMGYDNTENTWEPSSNMQNCKELVKIFNKLFKQFGLPVQQLTAADVANPQIATLHNNHLMXRAVVEAQLWRLVNQGYRAGMAQPQSTSRAFRSKSHIDERKRHESRREIALRGREDTGSLSCNRDNMKNNECKKTCNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9HQZ6</accession>
    <name>E9HQZ6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_65172</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732728">
        <property type="protein sequence ID" value="EFX65837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX65837"/>
    <dbReference type="EnsemblMetazoa" id="EFX65837">
        <property type="protein sequence ID" value="EFX65837"/>
        <property type="gene ID" value="DAPPUDRAFT_65172"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_65172"/>
    <dbReference type="eggNOG" id="KOG2668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038134_1_0_1"/>
    <dbReference type="InParanoid" id="E9HQZ6"/>
    <dbReference type="OMA" id="ERQYDSE"/>
    <dbReference type="OrthoDB" id="812555at2759"/>
    <dbReference type="PhylomeDB" id="E9HQZ6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901890">
        <property type="term" value="P:positive regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000049">
        <property type="term" value="P:positive regulation of cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070528">
        <property type="term" value="P:protein kinase C signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002090">
        <property type="term" value="P:regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="PTHR13806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="87"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX65837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
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        </source>
    </evidence>
    <sequence length="372" mass="41794" checksum="71B861651B54624E" modified="2011-04-05" version="1">MVWGFVTCGPNEALVVSGCCHRRPLLVPGGRAFVWPSVQQVQRISLNTMTLKVESPGVYTSQGVPISVTGIAQVKVQGQNEEMLLAACEQFLGKAEQEIRRVALETLEGHQRAIMGSMTVEEIYKDRKKFSRQVFEVASSDLVNMGITVVSYTLKDVRDDMGYLKALGMARTAEVKRDARIGEAEARADSQIKEAIAEEERLAARLVNDIEIAKAQRDFELKKAAYDQEVQAKKAEAELAYELQAAKTKQRLREEEMQIQVVERTQQILVQEQEILRKEKELDAKVRRPAEAEKFKLEKLADAHRQRVVLEAEAEAEAIRLNGEAQAFAIEAKAKAEAEQMSKKAAAFKEYREAAMVDMLLQTLPKVSLMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HR07</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX65826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_494562_0_0_1"/>
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            <begin position="209"/>
            <end position="233"/>
        </location>
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        <location>
            <begin position="460"/>
            <end position="492"/>
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    </feature>
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            <begin position="209"/>
            <end position="226"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="551" mass="62244" checksum="2162EAAA7D4ADC95" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9HRQ9</accession>
    <name>E9HRQ9_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_303586</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732740">
        <property type="protein sequence ID" value="EFX65549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65549">
        <property type="protein sequence ID" value="EFX65549"/>
        <property type="gene ID" value="DAPPUDRAFT_303586"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG1908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_420508_0_0_1"/>
    <dbReference type="InParanoid" id="E9HRQ9"/>
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    <dbReference type="OrthoDB" id="36396at2759"/>
    <dbReference type="PhylomeDB" id="E9HRQ9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="652" mass="71124" checksum="B93D926BA102ACDE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9HTR7</accession>
    <name>E9HTR7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_219469</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX64850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX64850"/>
        <property type="gene ID" value="DAPPUDRAFT_219469"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_219469"/>
    <dbReference type="eggNOG" id="KOG1491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_1_0_1"/>
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    <dbReference type="OMA" id="DFHDLCE"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="22"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="301"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX64850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="399" mass="44673" checksum="38C734DE128BC4F2" modified="2011-04-05" version="1">MPPKKETALEPKPLIGRIGTSLKIGIVGLPNVGKSTFFNVLTKSAAPAENFPFCTIDPNESKVGVPDERFDWLLQHYKPSSPKIQAYLNIVDIAGLVKGAHEGQGLGNAFLSHIRSVDAIFHLCRTFESEEITHVEGDVNPVRDIEIINEELRLKDEESLNAAIKKTESLMRSDKKLKAEYDILCKIKTHLVDQAKHIRYGDWNVQEIDVLNKHLFITSKPVIYLVNMAEADYIRKKNKRLPKLKEWIYSNDPGAIMIPFSGAFEAKIADMDEDTRKTFCEENKANSTFDKIIAQGYKSLNLMYFFTAGPKEVKAWTIQKGTKAPQAGGRIHSDFEKGFIMAEVFKFSDLKEEGSEAAVKAAGKYRQQGKLYVVEDGDIILFKFNAGAGLTAGKDAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HVI8</accession>
    <name>E9HVI8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_266780</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732857">
        <property type="protein sequence ID" value="EFX64243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64243">
        <property type="protein sequence ID" value="EFX64243"/>
        <property type="gene ID" value="DAPPUDRAFT_266780"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_266780"/>
    <dbReference type="HOGENOM" id="CLU_628924_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HVI8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX64243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="441" mass="50997" checksum="AEB2BEB0FACC6551" modified="2011-04-05" version="1">MFRRKCATNKRYGDIDARYAAEFPAVVKNPITKAKNIAHLSAAFHSRLQITLINVPRMGNQVDEQILRLYLDVKEPSNKILPDLTSQLPFLNLALHTLKERRNDFQSGERKIWKQLRELMRDIHWTIDDPKPIDLTQAFYTLQCLTHLVESQATPPTPIISKKSKTILKETKEIFLTYTRRILTFQLGQYLSLRTLEEYVPNPPAEFLGFVKQEDIANRDESGDYHEFLLNQIEFMFDFLHESFDTFQKIFLENTQTLIQFLKKLHKIQSIHNFQPELIRLQYRLNNFPRINWTFDREEVDNNKTLLAKTKRDLQIVLDFLQAPSPPHQSQIQRRATPTPKPAGPKDTANPAGTFQTTEQGKDRLISNLSANQPHSDKYTIRQSKTTLATTSATSTNGSTTSYDFKSVEANYTIDANYTVDANYTVEANYTIDANYTVEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HVZ1</accession>
    <name>E9HVZ1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_267092</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732882">
        <property type="protein sequence ID" value="EFX64092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64092">
        <property type="protein sequence ID" value="EFX64092"/>
        <property type="gene ID" value="DAPPUDRAFT_267092"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_267092"/>
    <dbReference type="HOGENOM" id="CLU_3056387_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX64092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="54" mass="5546" checksum="0FDA64F4B8067CE2" modified="2011-04-05" version="1" fragment="single">MADLTEELEHELAGDLVGDKLADVAGNFVVGELEAELADEFGGGNVGDLAGDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9HW53</accession>
    <name>E9HW53_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_334662</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732893">
        <property type="protein sequence ID" value="EFX64028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64028">
        <property type="protein sequence ID" value="EFX64028"/>
        <property type="gene ID" value="DAPPUDRAFT_334662"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_334662"/>
    <dbReference type="HOGENOM" id="CLU_072896_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HW53"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX64028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="205" mass="22827" checksum="0636063314E98E63" modified="2011-04-05" version="1">MGSDDDDDPGGDASVWGHTSLAISSASQSQSVHCKTCKSLFTPIDLRFKHCTSCKNNKPPKTKQGATKRDSSAALLSLQDSNVTKQQKDDNFPFQFDAAFEMDVVSFLSLDSTVQIDKFKSFFAKLEEEQVCAKTEKLFMSKKLDKLEKELENRATLRSELDLAKKDLAIAKLSLADKDIRLFELTNECQASPETVFGTSSRFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
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                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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        </source>
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        </source>
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</entry>
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    <accession>E9HXS7</accession>
    <name>E9HXS7_DAPPU</name>
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        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
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                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FOXP-CC"/>
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    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="474"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Arnold G.J."/>
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                <person name="Carmel L."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="EFX63350"/>
        <property type="gene ID" value="DAPPUDRAFT_119286"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_119286"/>
    <dbReference type="HOGENOM" id="CLU_994861_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="280" mass="30909" checksum="9C27E898A5EF6691" modified="2011-04-05" version="1">MVVFYESDYEDKRLKERTGKIDFKDFKDCKKCGNLIYPWNSHDCSLTEDADEPELEEDADELELGVAEDKPAFDEVQVVKHDAAVAKVADDPKLSEADDELGEEDKPSFDEVQACFLIFWRLDVTYNLNQGDIGAVVGVIRSDHVRADCCMQLGRDRGPLPDEPAERKPAADSLPGRDVVVVGSGREPAASAAAGQAEPAAVLLGQAEHRAGQQQFLLQQLDQPPPPERQTARLVRQLVRLPAPPMPPRHQAVTWRRRKSNSPVLWPSSASSTSSAGSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZM4</accession>
    <name>E9HZM4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotrans_gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_269690</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733374">
        <property type="protein sequence ID" value="EFX62805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62805">
        <property type="protein sequence ID" value="EFX62805"/>
        <property type="gene ID" value="DAPPUDRAFT_269690"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_269690"/>
    <dbReference type="HOGENOM" id="CLU_1391537_0_0_1"/>
    <dbReference type="InParanoid" id="E9HZM4"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="PhylomeDB" id="E9HZM4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotrans_gag" evidence="2">
        <location>
            <begin position="67"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX62805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="174" mass="20486" checksum="5222DD13197A7726" modified="2011-04-05" version="1">MNDLKELVAIPLREKIPHFSGRLDGIPVIDWFKQAERVAKGGNWSKEQMKRYFPERFLESAMSFQENLDDPDNPESVTEYNEWKDLIIKEFKDPTENQISKNELSEIKQTANERVRDFRARLEKLFAKACNEKLFHSTNEDMTLIRNDILKNAFELGLKGELLPGYENRPPQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9I108</accession>
    <name>E9I108_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RVP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_120336</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733674">
        <property type="protein sequence ID" value="EFX62322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62322">
        <property type="protein sequence ID" value="EFX62322"/>
        <property type="gene ID" value="DAPPUDRAFT_120336"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_120336"/>
    <dbReference type="eggNOG" id="ENOG502SYRF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375207_0_0_1"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="PhylomeDB" id="E9I108"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RVP" evidence="3">
        <location>
            <begin position="528"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX62322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="740" mass="80927" checksum="32A8025BE8BB36DF" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9I1B0</accession>
    <name>E9I1B0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_120417</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL733746">
        <property type="protein sequence ID" value="EFX62220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_120417"/>
    <dbReference type="HOGENOM" id="CLU_019853_3_0_1"/>
    <dbReference type="InParanoid" id="E9I1B0"/>
    <dbReference type="OrthoDB" id="1106566at2759"/>
    <dbReference type="PhylomeDB" id="E9I1B0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL735784">
        <property type="protein sequence ID" value="EFX60685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX60685"/>
    <dbReference type="EnsemblMetazoa" id="EFX60685">
        <property type="protein sequence ID" value="EFX60685"/>
        <property type="gene ID" value="DAPPUDRAFT_276129"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_276129"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012334_1_2_1"/>
    <dbReference type="PhylomeDB" id="E9I5P5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015248">
        <property type="term" value="F:sterol transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="PTHR10972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="SSF144000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX60685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="96" mass="10678" checksum="584A0118005F5F5A" modified="2011-04-05" version="1">MTAARKPFNPVHGEIFKCFCNMKDEATGEILLFRLVAEQVSHNPPVNAFHFECPQQRLSISGNLSIKAKFMGMYVGVTLGGDMVLELPAHNQSQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRZ6</accession>
    <name>E9FRZ6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_230081</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX89938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89938"/>
    <dbReference type="EnsemblMetazoa" id="EFX89938">
        <property type="protein sequence ID" value="EFX89938"/>
        <property type="gene ID" value="DAPPUDRAFT_230081"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230081"/>
    <dbReference type="eggNOG" id="KOG1003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055027_0_2_1"/>
    <dbReference type="InParanoid" id="E9FRZ6"/>
    <dbReference type="OMA" id="TEKRATN"/>
    <dbReference type="OrthoDB" id="1576041at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
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        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX89938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="284" mass="32786" checksum="1688F9FD90036A4C" modified="2011-04-05" version="1">MDAIKKKMQAMKAEKDNAMDRADTCEQQSRDANLRAEKSEEEVRALQKKMQQLENDLDQAQENLLAANSKLEEKDKALQTAEGEVAGLNRRVQLLEEDLERSEERLNTATTKLAEASHSADESERMRKVLENRSLSDEERMDALENQLKEARFLAEEADRKYDEVARKLAMVEADLERAEERAETGETKIVELEEELRVVGNNLKSLEVSEEKANQREEAYKEQIKTLTTRMKQAEARAEFAERSVQKLQKEVDRLEDELVHEKEKYKSIADEMDTTFVELAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E9FTU1</accession>
    <name>E9FTU1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_303213</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thrombospondin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89583"/>
    <dbReference type="EnsemblMetazoa" id="EFX89583">
        <property type="protein sequence ID" value="EFX89583"/>
        <property type="gene ID" value="DAPPUDRAFT_303213"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303213"/>
    <dbReference type="eggNOG" id="KOG1216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_224851_0_0_1"/>
    <dbReference type="InParanoid" id="E9FTU1"/>
    <dbReference type="OMA" id="NINWRIE"/>
    <dbReference type="OrthoDB" id="12226at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="Unchr_dom_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025155">
        <property type="entry name" value="WxxW_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13330">
        <property type="entry name" value="Mucin2_WxxW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="SSF57567"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="SSF57625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01185">
        <property type="entry name" value="CTCK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX88274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="355" mass="40409" checksum="820D75057A60FC81" modified="2011-04-05" version="1">MCLREEFLDHKKQSATHPQQRQPAEGKASLHVLDARRSIPISDVNLQKDRPVCMSFLRVRRSRVEYYTEASNYYTTTNHRREKAIDISRMAPPHYTTKAPEYCTTIYHGLVEIKGERNKQSCDVRVASKYFTTKAPECYTTTDVAPNQSYTEAPNYCTTKALEYYTTTISRVVIYDMATTAAAFFVVPPVLQLWLYVYSIFLNAINYYVVLLLGVVSLMAESTTGLLMSPGYGGYQSTTPPSYYATTTYDTTSYYTEAPKYYTTKEPDYYTTTNAAPAYYTEAPKYYSAPSYYTEVPAYYTTKTSTQFLYGIVWSWHGDSCANAVNMLLQSTENVEKMDTKTSPLIVGCHAFVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYJ6</accession>
    <name>E9FYJ6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DAPPUDRAFT_192225</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + H(+) = diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:34936"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:16014"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="5"/>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87538"/>
    <dbReference type="EnsemblMetazoa" id="EFX87538">
        <property type="protein sequence ID" value="EFX87538"/>
        <property type="gene ID" value="DAPPUDRAFT_192225"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_192225"/>
    <dbReference type="eggNOG" id="KOG2298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_1_0_1"/>
    <dbReference type="InParanoid" id="E9FYJ6"/>
    <dbReference type="OMA" id="EPSYGID"/>
    <dbReference type="OrthoDB" id="1183820at2759"/>
    <dbReference type="PhylomeDB" id="E9FYJ6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00458">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00991">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00762">
        <property type="entry name" value="WHEP_TRS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51185">
        <property type="entry name" value="WHEP_TRS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WHEP-TRS" evidence="15">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="208"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFX87538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="678" mass="76999" checksum="8BFA691D2AD72DE8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9G052</accession>
    <name>E9G052_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_96956</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87457"/>
    <dbReference type="EnsemblMetazoa" id="EFX87457">
        <property type="protein sequence ID" value="EFX87457"/>
        <property type="gene ID" value="DAPPUDRAFT_96956"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_96956"/>
    <dbReference type="eggNOG" id="KOG1720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019730_1_0_1"/>
    <dbReference type="InParanoid" id="E9G052"/>
    <dbReference type="OMA" id="QQTIWIK"/>
    <dbReference type="OrthoDB" id="828691at2759"/>
    <dbReference type="PhylomeDB" id="E9G052"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035335">
        <property type="term" value="P:peptidyl-tyrosine dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="104"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="5">
        <location>
            <begin position="190"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX87457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="496" mass="55739" checksum="2BD081BD459160FA" modified="2011-04-05" version="1">MAARSHMSMLFRQKSKVGSPGVAKNQNDVPADSTAASTLSKLPENAEKSATPPLVAQPSYTKLSEGLRKNTPASVICLAFCGGRKCRFDTSDRWTAEDMAVNGLYSHWITEDILAMARPNAQLIQKNDIVGQFIRLGIKTIINLQTAGEHSHCGPPLTSSGFSYLPESFMEKDIFYYNFGWKDYENGSLEGLLDAVKVLTFAVNQGKVAVHCHAGLGRTGVLLCCYLIYSQRLRSVEAIRHVRRKRPNTVQTSSQIMMIQEFEQFLINCFSVFSTSKADVKNSSAKHPFTLSHHLEDQKEVLHGYEARALRYIPKVIFEEIVNSLLANPPTDLLAHPTVKDYCLTLDGRQSGWKKLSSERDPKILSRLLFYWLLHLKNPILTNEELSNIVVYADKPAICLSRFDLATRYTVEYLLRFIQRLCPTANNARFDLNRRLASLLTQQAVEIRGIYFPSDGRKRLGQGTLAQLLHFLNSAIELFVNEVVTISEESASSIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9G2B4</accession>
    <name>E9G2B4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_98098</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732530">
        <property type="protein sequence ID" value="EFX86217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86217">
        <property type="protein sequence ID" value="EFX86217"/>
        <property type="gene ID" value="DAPPUDRAFT_98098"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_98098"/>
    <dbReference type="HOGENOM" id="CLU_2075526_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9G2B4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX86217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="118" mass="13503" checksum="AE3F0456A9ACC0AC" modified="2011-04-05" version="1">MCLYIYQICLMNVKCLTEFVSQKHHHLSPCYYKLLPEKLHTPAVTHHRIKPRARSFFMESCRPGTEILVPMLAFVHERRVTLRPVTTQQEVAGHSQSRGITQPSTAVADPPRSILVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9G358</accession>
    <name>E9G358_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_8835</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85717"/>
    <dbReference type="EnsemblMetazoa" id="EFX85717">
        <property type="protein sequence ID" value="EFX85717"/>
        <property type="gene ID" value="DAPPUDRAFT_8835"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_8835"/>
    <dbReference type="eggNOG" id="KOG0490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049543_12_1_1"/>
    <dbReference type="InParanoid" id="E9G358"/>
    <dbReference type="OMA" id="EIAMWIN"/>
    <dbReference type="OrthoDB" id="868593at2759"/>
    <dbReference type="PhylomeDB" id="E9G358"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="Homeobox_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX85717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="57" mass="7148" checksum="9DAF19B684ADE9F7" modified="2011-04-05" version="1" fragment="single">RTTFTNFQLEELEHAFHKTHYPDVFFREELAVKIDLTEARVQVWFQNRRAKFRKHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9G410</accession>
    <name>E9G410_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_313738</name>
        <name evidence="3" type="ORF">DAPPUDRAFT_313741</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="eggNOG" id="ENOG502QRS9">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Dysbindin"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="250" mass="28729" checksum="4AA5BEC707ADA812" modified="2011-04-05" version="1">MLPANLREKLFQVQEELASSLRTLGLTEPISPLVIPSRHGKHFEGVRLDAGADLLNHYQFQWCRMREASDINYHLAEQADKAIASVESYINRQHHLVSTLTTNLSSVSLMMIQLQKITESMSVTEATLKKTEEHLALLEDLVKDSQLESEIKEHDKKFVLLQDQKFAELESLKNHLAATHLQKVREYESKQVLKAKERQAIFEQAFETEIQQYKQSGIIPRMSQSNRQTTSLEEIVVEDDPSSLNQFLDE</sequence>
</entry>
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            <taxon>Daphnia</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX84387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84387">
        <property type="protein sequence ID" value="EFX84387"/>
        <property type="gene ID" value="DAPPUDRAFT_238655"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238655"/>
    <dbReference type="HOGENOM" id="CLU_030601_0_0_1"/>
    <dbReference type="InParanoid" id="E9G719"/>
    <dbReference type="OMA" id="LFMIHER"/>
    <dbReference type="OrthoDB" id="1376558at2759"/>
    <dbReference type="PhylomeDB" id="E9G719"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX84387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="419" mass="47994" checksum="96E2252D9EE4C143" modified="2011-04-05" version="1">MTPKPEGGFTYVYEWKEGTERKKDDDGQNLLSSKFTRTAFHHPTLPKVLISYKGDETLSSKLPHGNSTSVESKKLPFVPTMPSLLRDIEEKKGDYPANVYRKINATVNRSIKEQAAQAPRNLKQVQNTMHNLTQKLRLSRDSLYNLHVRAFDGTFIKEILTFPDLVVIGWNDGIAGAFLSLLGTSQSVGLFYDTTFRLGDYYVSILSFLDVEFTNKPTIPLLFMIHERKTFETHDLFWRKVKNKLPGLSKAKNVYIVSDEESAIVEAMRQNLPMTDLSLLEPCHAKCQAFGKYFRKCIHKDIERLGLWVIRKHGLTSATNNRAESMNTMLKRFVNWKESPVDAIVLSLEELSASFYAEILRGRYRRGNFNLHEDFESLYDLEKDCPVLPEITDAEEIFMKFQNAIKNVSKAGTMDLTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7K3</accession>
    <name>E9G7K3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX84481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_314815"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_314815"/>
    <dbReference type="HOGENOM" id="CLU_334092_0_0_1"/>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="855" mass="85924" checksum="6624CAC0648298D4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7Y1</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="2">
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            <taxon>Daphnia</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Koonin E.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1662555_0_0_1"/>
    <dbReference type="InParanoid" id="E9G7Y1"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="PhylomeDB" id="E9G7Y1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX84581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="159" mass="18254" checksum="F00F3B3E928B13BD" modified="2011-04-05" version="1">MTKKTLQAVLSMGLDDDELEDHEVIIQQLRDRCNAGRNRHVWRQQFAMKKQRANESADNWLCELRELASKCEFLKDCCSKCQPTRILGQIVFGVYDDDVRRKLLERGDTVATRSFRTAERSLWENGKTTALTGQTSNVSPSAISAGPFRCFRRLIISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9P3</accession>
    <name>E9G9P3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_301554</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83603"/>
    <dbReference type="EnsemblMetazoa" id="EFX83603">
        <property type="protein sequence ID" value="EFX83603"/>
        <property type="gene ID" value="DAPPUDRAFT_301554"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301554"/>
    <dbReference type="eggNOG" id="KOG0646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029749_0_0_1"/>
    <dbReference type="InParanoid" id="E9G9P3"/>
    <dbReference type="OMA" id="VNARIYT"/>
    <dbReference type="OrthoDB" id="747023at2759"/>
    <dbReference type="PhylomeDB" id="E9G9P3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097344">
        <property type="term" value="C:Rix1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="PTHR18763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX83603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="424" mass="46687" checksum="C1EB83F812CA85A5" modified="2011-04-05" version="1">MEVVVTSECSGQLWNTCIWEPLTGTTLRTFKGGISGSQSLNIVGGDYLLSSLKDKPIIQVWALNRQDQITTKMIMPGIIQVLVMSPCNNFCVGALSEQLLVWQVSTGKLVASLRRHYQNVSDVKFTADSSRFISAGAEGLVLLWSLDTVLHTKECEPDSIWSDHSLPVTGLHVTKSLIQPLVFSVSLDQTCKIRDLNTGKTLFNIQFNGPLRSVVVDHSEESCYVGSHEGKIYRLDLLDPPRSVEQMVDESASRKMFVGHEKAVTCLSVSTGGCHLLSGSDDGSARVWDIASGQCVRILAHRGPLTNAFFAPRYKHLETDKFHPRIIINTFEKKRHDGQLLSAENELNAQVLISCPPLMESLDSSQGAEALSLSGSNASGGHQVSDQVTQNEMGRLKLINRQLYAFAVDKIFNEDAAITTKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9W2</accession>
    <name>E9G9W2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Multiple inositol polyphosphate phosphatase 1</fullName>
            <ecNumber evidence="4">3.1.3.62</ecNumber>
            <ecNumber evidence="3">3.1.3.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2,3-bisphosphoglycerate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_301637</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27381"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="3.1.3.80"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. MINPP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.62" evidence="4"/>
    <dbReference type="EC" id="3.1.3.80" evidence="3"/>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83810"/>
    <dbReference type="EnsemblMetazoa" id="EFX83810">
        <property type="protein sequence ID" value="EFX83810"/>
        <property type="gene ID" value="DAPPUDRAFT_301637"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301637"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029165_0_0_1"/>
    <dbReference type="InParanoid" id="E9G9W2"/>
    <dbReference type="OMA" id="ILYHLGG"/>
    <dbReference type="OrthoDB" id="1046588at2759"/>
    <dbReference type="PhylomeDB" id="E9G9W2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034417">
        <property type="term" value="F:bisphosphoglycerate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052826">
        <property type="term" value="F:inositol hexakisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237275" description="Multiple inositol polyphosphate phosphatase 1" evidence="10">
        <location>
            <begin position="22"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="79"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="435"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX83810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="464" mass="54016" checksum="901CACADF48F5B17" modified="2011-04-05" version="1">MPKLFIQILLLSCLVLLTVQAGKRSSKESKKEKHKASSLKNKSEYCYDDIDHPYVFFATKTSYRWNRNKNDDEITPPGCVAQQFWLLSRHGSRNPSTEEMLTLKSILPLIQNEIISNHKAGKGSLCKDDIENLEKWIFRANVNDDEFLVKEGFKELEDIADRYQDRFPKLLTKPFINSSYIFKHTETERTNASARAFAKGLFGKKDIPNVFFQELNSPDSLLKFDEICDKWRKEVHKKKKALIEKTLFEESGEMLSVIQSVTNRLGFLSPLNLNDINEMYTMCTFDKAWRPKKLSPWCAVFSKEDLKILEYREDLKYYFEDGYGFPINYEQACMPLKNVYDSFRHVVESPASSNPKGIFYFTHTATLLKVMARFGLFKDSIEMKHTNRHLMKNREWRTSLINSFAAHLALVLFNCSDGHYITAYVQERPIILPGCSSELCKYSDFTKKYEKFATSCNVDDICRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9W4</accession>
    <name>E9G9W4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_100257</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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    </evidence>
    <sequence length="164" mass="18462" checksum="F1A1D800BC06B6D3" modified="2011-04-05" version="1">MCKIFYKFINDINHEKKVVWSCGPSSVVTIISFLNMQTCTKNLFVLGCADFSKTELRLCCSQHTGGRQLTTYQNRKQADQLVSEVSEEKTSRVKKQGIDLILIASATPDATVLVVIGRKISDYRVPTLTNKSQFIIDRHGKRGKVVDETYRSTTAPHKMKKTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9GA08</accession>
    <name>E9GA08_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_301644</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Golgi apparatus membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EFX83790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83790"/>
    <dbReference type="EnsemblMetazoa" id="EFX83790">
        <property type="protein sequence ID" value="EFX83790"/>
        <property type="gene ID" value="DAPPUDRAFT_301644"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301644"/>
    <dbReference type="eggNOG" id="KOG0292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9GA08"/>
    <dbReference type="OMA" id="ICAEYIV"/>
    <dbReference type="OrthoDB" id="139008at2759"/>
    <dbReference type="PhylomeDB" id="E9GA08"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006888">
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        <property type="project" value="GO_Central"/>
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    </dbReference>
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        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Coatomer_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
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    </dbReference>
    <dbReference type="Pfam" id="PF06957">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
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    </feature>
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    </feature>
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            <begin position="841"/>
            <end position="855"/>
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    <sequence length="1224" mass="137214" checksum="3AD8126A6B0FAD32" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9GA16</accession>
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        </submittedName>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX82755.1"/>
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        <property type="gene ID" value="DAPPUDRAFT_101359"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240223" evidence="1">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX82755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="136" mass="15856" checksum="89B9703D13AB2582" modified="2011-04-05" version="1">MAMEFLFVVFVASLSKSPFADHSLCGSRPAVYFVPTEYHQPNSAEKMEEYRKNMEKGEKPELGQIKQYVDPMNMKLSCKEIQQVLPDAVIEKLMLDPILFRFRYGNRLPFYGHRYLGVLSRSLYDRAGKSCWECPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GD58</accession>
    <name>E9GD58_DAPPU</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DAPPUDRAFT_240994</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX82750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_240994"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX82750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="215" mass="24444" checksum="3BCBDDCBA7F87028" modified="2011-04-05" version="1">MECQPKLPTPPCYVPPAPNCQPCPAASTCICPTATPCPAPPEQPKSIEIFTRGQRISKTVSQWLNLYPPYSKNRLIVVTTLLDDMIEPWALVGSIHRCTADSNNGHFNTTCPICQDRYEYIKCVMSANLIEEHTLPTMAKGNGWFNQDPEFTPMRGWLPQFVYHLWFDNKIDGTMSRYQQEINAMTVRTTSGSPCRVCKDFNRSVYEKCYSRPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDT2</accession>
    <name>E9GDT2_DAPPU</name>
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        <recommendedName>
            <fullName evidence="2">KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_101570</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82137">
        <property type="protein sequence ID" value="EFX82137"/>
        <property type="gene ID" value="DAPPUDRAFT_101570"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_101570"/>
    <dbReference type="HOGENOM" id="CLU_612902_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="101"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX82137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="447" mass="50041" checksum="18B58701AF9AE93C" modified="2011-04-05" version="1">MPLLPQQQRSMIHMKNALIAGINLSSKFNAPGQPSGIEVGQPIFGSSVTNRGPPQNTALQSWKQDIQLAPACSLLMDTVGSTTPLPPQPIQITADSSVQPSKEWQQSLDTELRSHSRHKIALAIAPTPDVYAKLLEHHDIVGFVVKLESDMYDISDSLSEYCKLADTIMFYFKEIPYETYLQHKQAKLTLSHALTMPLQQFTSTPLSHDPSSDDPIPPQQQQIIPLSKVMKQLDENNPSYAWQHVPLSSTALQSQAKGIDLTTACPMSPQNMSQCWHQRQQFTSVPGFDTQLSGPTPYCDFTTDPFCKNLLPCHDIADPIQPHFTQTNFQSFQEQQSEPSSNNPVLRSNVPWIEESEQEQFGTVPRSGMMLLHSVSCSPEGIVQMPNELIQQLQQIFDMVPLSLDRCIELLYQSLPGWSQINVRNNPVNSRLPFSRANVNLNVSQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9GE29</accession>
    <name>E9GE29_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX82385"/>
    <dbReference type="EnsemblMetazoa" id="EFX82385">
        <property type="protein sequence ID" value="EFX82385"/>
        <property type="gene ID" value="DAPPUDRAFT_302551"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302551"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="E9GE29"/>
    <dbReference type="OMA" id="NGGQLIC"/>
    <dbReference type="OrthoDB" id="1051625at2759"/>
    <dbReference type="PhylomeDB" id="E9GE29"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX82385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="288" mass="30883" checksum="4D89BC8D2E8523AF" modified="2011-04-05" version="1">MLKTTTLVLSRRFLLSSQDVRQIGTAAEVARQRRSLKGRVAVVTASTDGIGFAMAQRLAVDGAHVVISSRNQKNVDEALAKLKSEGLSVSGMVCHAGVKEDRTRLIEKTAAEFGGFDILISNAAVNPGGVKRLLNCTEDVWDKIFDVNVKSSFFLAKEALPHMEKRGKASIIFNSSILGYTPNCGVDFMGAYALSKTAILGLTKLMAMELGPRGVRVNCICPGLIDTRFGSAITQDERSKQIMQINCPLQRNGMPEEMAGLASFLASDDSSYITGSNIVAAGGIQSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEM5</accession>
    <name>E9GEM5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_128092</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732541">
        <property type="protein sequence ID" value="EFX82055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX82055"/>
    <dbReference type="EnsemblMetazoa" id="EFX82055">
        <property type="protein sequence ID" value="EFX82055"/>
        <property type="gene ID" value="DAPPUDRAFT_128092"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_128092"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="E9GEM5"/>
    <dbReference type="OMA" id="DIPFHRD"/>
    <dbReference type="OrthoDB" id="930292at2759"/>
    <dbReference type="PhylomeDB" id="E9GEM5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046777">
        <property type="term" value="P:protein autophosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017348">
        <property type="entry name" value="PIM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037993">
        <property type="entry name" value="STPK_Pim-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="31"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="37"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX82055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="315" mass="35411" checksum="7CF3F6EBC16CF965" modified="2011-04-05" version="1">MATVAPASSSGVATPSSQMALMDCETFGRTYHVGHVLGKGGFGTVYAGNRIRDGLPVAVKHIHKSSVTTWSHVNGVRVPLEFCLLRQVAHVPGVVRLLDACDADDVFVLVMERAESSQDLFDFITERGALPEQAARNFFRQVVEAVVQCHRAGVIHRDIKDENILVDLKTHCLKLIDFGSGDYLKDGVYTEFDGTRVYSPPEWIRHRRYHGRPATVWSLGILLYDMVCGDIPFEQDDQIVRATVNFVTRSPGRLRLSPQCEDLILRCLEYRPADRPSLEHILAHPCSNDDVMRYIKTARVHLYPSLIGINFRQHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GF78</accession>
    <name>E9GF78_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_102053</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732542">
        <property type="protein sequence ID" value="EFX81590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81590">
        <property type="protein sequence ID" value="EFX81590"/>
        <property type="gene ID" value="DAPPUDRAFT_102053"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_102053"/>
    <dbReference type="HOGENOM" id="CLU_1099445_0_0_1"/>
    <dbReference type="OrthoDB" id="1708759at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX81590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="253" mass="29009" checksum="F8793542C9BE0084" modified="2011-04-05" version="1">MIRKGRKPTPQSDEERLQQEKEKEESQLRKAANRNAAKRAKQERKFNMGPVLGHAKELTDKSETNNQERQLKQQAQRSSHKTQPRYNTKSSSSAVNEDFDCLADPEGMDQARMVNSYVNENTVNSSMFDQGSKENAIQKLREKLQELMIASEVEANQAIADSVSPEIKEKKKIISEEKDLDCLWTDVESLAFKAFEHHHGIRGFSCKNCGYQSNQIINCLDCSEKLCGKCDEKIHLRIPFHQRSFYSNTRPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GFE7</accession>
    <name>E9GFE7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_241929</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
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                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_241929"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2457044_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GFE7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240302" evidence="1">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="89" mass="9757" checksum="BC516EDC8D567C5D" modified="2011-04-05" version="1">MKLGLIILLGLVAITASQPVVETAAVPIEDTEAAEDSAIDMMPEESALKIIMHKLDHWLKKCYKKGGCRQDYGHQSYGGYGHDSYGYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_317653"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="265" mass="30769" checksum="3511F21DF0DEA885" modified="2011-04-05" version="1">MRFEPIRDFSKSLKMNKNQEAKLEEAVLKDLVWIAKEQLTSSKEEVKKVLTAKTAAGMPHKTWLNQLEMLEKRIKKKIALEVYPKYAGYDGRFLRQWWRCNLDPSFLRGLLGTKEIGLLKTLTKDSNPENEIDFEAIAAEISTKLKIQKRHKFQLFQYYQKNLNMKNRTFGWAKAEEERLQNLYKEKSTDHNMPKKQEIWNQIRPAFPGRSVSQMETKLKRLSTPAKSPAKCLPAAIKTVVTRAVARAMTTRATVRAKGKKTKPD</sequence>
</entry>
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            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
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    <organism evidence="4">
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG3700">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="E9GIE8"/>
    <dbReference type="OMA" id="FMWFLST"/>
    <dbReference type="OrthoDB" id="1171418at2759"/>
    <dbReference type="PhylomeDB" id="E9GIE8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
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        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
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        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="6"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX80783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="376" mass="43408" checksum="F102656BFDA381A5" modified="2011-04-05" version="1">MQTIGNASVSVDTFFLISGLLASFLLLRELDRNKGKFNVGLFYLHRYLRLTIVYAFVLGFIASLNVYVGTGPNWYDVNKYSNACRLAWWRQFFYINNLFPTDPNYGCMVQTWYLAVDMQLFVVAPLLIYPLWRWKKWGLAWLAFIALLCQASIFYVYAKYDLSPTAWATRTDDWATITDYNDHYYFKPWTRAPPYLVGILVGWYLSITKNSPTRLSKPLVAIGWTLSIAVGLAIVYGLAPYVDESTVPEISPSLKMTYGPLHRTAWACVIAWIIFACSRGYGGFVNRLLSWRGFIPFGRLTYCVYLVHLDYLIIFYAAVRKQFYYTLYEQFTTCFGVLVFVFLLAFVVSLTLEASFLNLEKFIFSSKPKSDSLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIS7</accession>
    <name>E9GIS7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_50880</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732546">
        <property type="protein sequence ID" value="EFX80602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80602"/>
    <dbReference type="EnsemblMetazoa" id="EFX80602">
        <property type="protein sequence ID" value="EFX80602"/>
        <property type="gene ID" value="DAPPUDRAFT_50880"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_50880"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009579_3_3_1"/>
    <dbReference type="InParanoid" id="E9GIS7"/>
    <dbReference type="OMA" id="INAFFTI"/>
    <dbReference type="OrthoDB" id="1262707at2759"/>
    <dbReference type="PhylomeDB" id="E9GIS7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F1_2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX80602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="341" mass="38699" checksum="0F677C68B0567BBD" modified="2011-04-05" version="1" fragment="single">RLVFSVTLSNLIFSFCVFPCILVSSIKQQWIFGSIWCYINAFFTILVTVASSATLAAIALDRYFAIVRPMQYSRKMTRNRANGLLIFAWCLGLVCALPPLFGWSAYDYEESHRACFLGWTSSLSYSAVLLVITFCFPLVSMLVFYYAILQVARTKCKRINFDMSALHQYQQQSQHRNVAHKHVTSSPEFFGLFFQFHLIKKGMRTIFLVLAAFLLTWIPMLVLALLEMIRHLGGLGSWTPPHWLYVFAMWSMCAGSVTYPILYGIYNRAIRKELRLCLSCSGGLNAKKWRNVNHFYHHGGSGHGGGGGGGVGQRRGSKWSNYSGPFQHQSFLFLFTAGHQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIY9</accession>
    <name>E9GIY9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_304079</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80573"/>
    <dbReference type="EnsemblMetazoa" id="EFX80573">
        <property type="protein sequence ID" value="EFX80573"/>
        <property type="gene ID" value="DAPPUDRAFT_304079"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304079"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_15_1"/>
    <dbReference type="InParanoid" id="E9GIY9"/>
    <dbReference type="OMA" id="FIANFTC"/>
    <dbReference type="OrthoDB" id="724235at2759"/>
    <dbReference type="PhylomeDB" id="E9GIY9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="54"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="537" mass="58951" checksum="462DD52A68CC717C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJH2</accession>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="175" mass="19896" checksum="3D4AD9422F828E93" modified="2011-04-05" version="1">MLPTLNEQETHRFKRTLYHFIRANYRFNRVGQGNLLHLACCSYTIITKLFPLDVMKLLLELGVDPSATSSNGMTALHVLASIEWERWSTNITDAIQLLLDSDAHIDQPDDEGITALDLFKLKEKELAENGISNDYLQRLIHKVRPLTCLAAQVVSRHGIPFDDLPSSLISFVNRH</sequence>
</entry>
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        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <location>
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            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="259" mass="29273" checksum="EB7CF10A06268274" modified="2011-04-05" version="1">MTTPTNEASWRGMKGHVTRWINNIQKFDNVQMDLTTLNQVLVAESNLRNTYSKYKRISEGVARDMEQAGATQEEFQEEVDSQIKVEEEVGDALMIVKRKREELKEIQAAEERKRHEDMLLLMFKTQQIAADATRAQEKADQDAARAQEKIDEDAARAQERAIRQQENQDKQNLFRQLIAAIPAAAAPGAPAAPAAVASTKLPKRQIKPFKGDVLEWTAFWEGYNAAVHGSAIPALKNFIPLEGREWITSDKEKLLCILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKT7</accession>
    <name>E9GKT7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HRDC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="4">
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Shiga Y."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:polyadenylation-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
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        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="PTHR12124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="2">
        <location>
            <begin position="447"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX79910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="834" mass="94120" checksum="296EB4E4D9DABAB3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9GLF8</accession>
    <name>E9GLF8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="8">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_319346</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="8"/>
    <dbReference type="EMBL" id="GL732551">
        <property type="protein sequence ID" value="EFX79508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79508"/>
    <dbReference type="EnsemblMetazoa" id="EFX79508">
        <property type="protein sequence ID" value="EFX79508"/>
        <property type="gene ID" value="DAPPUDRAFT_319346"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_319346"/>
    <dbReference type="eggNOG" id="KOG0260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000487_3_1_1"/>
    <dbReference type="InParanoid" id="E9GLF8"/>
    <dbReference type="OMA" id="SECLSTM"/>
    <dbReference type="PhylomeDB" id="E9GLF8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLA_N" evidence="9">
        <location>
            <begin position="227"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX79508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="878" mass="99323" checksum="C6D724440A6C64DF" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9GLK3</accession>
    <name>E9GLK3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_304481</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732551">
        <property type="protein sequence ID" value="EFX79676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79676"/>
    <dbReference type="EnsemblMetazoa" id="EFX79676">
        <property type="protein sequence ID" value="EFX79676"/>
        <property type="gene ID" value="DAPPUDRAFT_304481"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304481"/>
    <dbReference type="eggNOG" id="KOG0628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011856_3_0_1"/>
    <dbReference type="InParanoid" id="E9GLK3"/>
    <dbReference type="OMA" id="PANQFRP"/>
    <dbReference type="OrthoDB" id="856958at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004398">
        <property type="term" value="F:histidine decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001694">
        <property type="term" value="P:histamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006548">
        <property type="term" value="P:histidine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
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    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
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        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="569"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="614"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX79676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="667" mass="74324" checksum="B61F20AC5F269375" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E9GLV2</accession>
    <name>E9GLV2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DAPPUDRAFT_304508</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
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    <dbReference type="EMBL" id="GL732551">
        <property type="protein sequence ID" value="EFX79573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79573"/>
    <dbReference type="EnsemblMetazoa" id="EFX79573">
        <property type="protein sequence ID" value="EFX79573"/>
        <property type="gene ID" value="DAPPUDRAFT_304508"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304508"/>
    <dbReference type="eggNOG" id="KOG0612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_140_0_1"/>
    <dbReference type="InParanoid" id="E9GLV2"/>
    <dbReference type="OMA" id="WTFENLR"/>
    <dbReference type="OrthoDB" id="759391at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072518">
        <property type="term" value="F:Rho-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018107">
        <property type="term" value="P:peptidyl-threonine phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901888">
        <property type="term" value="P:regulation of cell junction assembly"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AGC-kinase_C"/>
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    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PE/DAG-bd"/>
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    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PH_domain"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="ROCK_Rho-bd_dom"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rho_Binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PH"/>
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        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF57889"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHO_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 15 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="78"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="22">
        <location>
            <begin position="341"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="RhoBD" evidence="23">
        <location>
            <begin position="956"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="19">
        <location>
            <begin position="1124"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="1238"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="692"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1020"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1209"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1337"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="801"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="864"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1210"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1354"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01206"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Zdobnov E.M."/>
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                <person name="Dusheyko S."/>
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                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Tsuchiya D."/>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="103" mass="11617" checksum="F4FDB99518FCCD64" modified="2011-04-05" version="1">MPKRQSPEAVQNVQSSANENCVPRSRSPLQSRRPTPPVVAPVLVLLPVRAPAPAMVVPPHLDRFQCPNFRINGFYPARELCIYDHGYQPPDQGIREENVTFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9GWV2</accession>
    <name>E9GWV2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="1">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_249535</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="1"/>
    <dbReference type="EMBL" id="GL732571">
        <property type="protein sequence ID" value="EFX76055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76055"/>
    <dbReference type="EnsemblMetazoa" id="EFX76055">
        <property type="protein sequence ID" value="EFX76055"/>
        <property type="gene ID" value="DAPPUDRAFT_249535"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_249535"/>
    <dbReference type="eggNOG" id="KOG4276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2485598_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048856">
        <property type="term" value="P:anatomical structure development"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="PTHR45670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="SSF56204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="87" mass="9886" checksum="CC02638547FEA74C" modified="2011-04-05" version="1">MSGDAGKWRGLYVELMAKFCLERGIHRQEFNHVFTMSRLAGFSPSELQLLLCGDQSPSWTREDILNYWRRSWATPATARASNGSSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GXZ3</accession>
    <name>E9GXZ3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_250129</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732574">
        <property type="protein sequence ID" value="EFX75647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75647">
        <property type="protein sequence ID" value="EFX75647"/>
        <property type="gene ID" value="DAPPUDRAFT_250129"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_250129"/>
    <dbReference type="HOGENOM" id="CLU_2087234_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="117" mass="13612" checksum="64DCCD0A066F9596" modified="2011-04-05" version="1">MDIHQWKCFKHEKEVDKELNYGLRKKDNIDQNIVVFPEEKATFNEHHPSLFLNLEESVTLGLNVIGNRERSFLPAEADRTNYYNMKDGTYTAGVYVYGDSDNTTSDEETIPYADEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZ46</accession>
    <name>E9GZ46_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_250691</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732576">
        <property type="protein sequence ID" value="EFX75296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75296">
        <property type="protein sequence ID" value="EFX75296"/>
        <property type="gene ID" value="DAPPUDRAFT_250691"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_250691"/>
    <dbReference type="HOGENOM" id="CLU_2485600_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GZ46"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="87" mass="10077" checksum="53615F40D04BC7DA" modified="2011-04-05" version="1">MDDSSKEQTAFIPELVINQEVEEHFKNLWVISPFFLCPLLGHQDLLAVVKSYHRSSTSIYLRKLINKRSPTQPDRNTLFLVEVLFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZA5</accession>
    <name>E9GZA5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_323613</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732577">
        <property type="protein sequence ID" value="EFX75192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75192">
        <property type="protein sequence ID" value="EFX75192"/>
        <property type="gene ID" value="DAPPUDRAFT_323613"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_323613"/>
    <dbReference type="HOGENOM" id="CLU_2135982_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="113" mass="12597" checksum="73779B3802D44987" modified="2011-04-05" version="1">MSLLAKTKNKPRKQVTREQMFTESMMLFRSMANTLQDLSLPSYQKNMRMLTQIHSYIMEMRSFHLTLSASASGPVSVQEEPLVDLADAARAVTTTQFTTPEELGLGEVGPAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZW4</accession>
    <name>E9GZW4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_251182</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732579">
        <property type="protein sequence ID" value="EFX74885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74885">
        <property type="protein sequence ID" value="EFX74885"/>
        <property type="gene ID" value="DAPPUDRAFT_251182"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_251182"/>
    <dbReference type="HOGENOM" id="CLU_960641_0_0_1"/>
    <dbReference type="OrthoDB" id="1748723at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="290" mass="32241" checksum="FB083454F05A4028" modified="2011-04-05" version="1">MALVERARRATIRHRTSIASSIPLSPIPDRSLYPLSLWSNGELGIGTLEAIAVPKDFHDHSFDHQLEQLKGFVGTNKVIGINNPGWNLPVESTTKSRSQVQHDMRSCKVISYSEDRDLVVIVRDAMLPPISVQKAVAKKSAPKSSATQKHGTGHKSTSPPRNLSVEKSSTGSTNGLHYLQCRTLTCYTVIRKTMDILYEDMEGLDFQLITGGNEDKSNESADSSLHHEDDQQGIFSSESEDEDVIPPTPPPAKRKRRNQSVKSLSSTKSKREKKDGDLESNYKRVNYNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZX2</accession>
    <name>E9GZX2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Histone deacetylase</fullName>
            <ecNumber evidence="2 5">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RPD3</name>
        <name evidence="11" type="ORF">DAPPUDRAFT_442930</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone]</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 5"/>
    <dbReference type="EMBL" id="GL732579">
        <property type="protein sequence ID" value="EFX74892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74892"/>
    <dbReference type="EnsemblMetazoa" id="EFX74892">
        <property type="protein sequence ID" value="EFX74892"/>
        <property type="gene ID" value="DAPPUDRAFT_442930"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_442930"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_7_4_1"/>
    <dbReference type="InParanoid" id="E9GZX2"/>
    <dbReference type="OMA" id="EFCKISC"/>
    <dbReference type="OrthoDB" id="732770at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016575">
        <property type="term" value="P:histone deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="His_deacetylse_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="10">
        <location>
            <begin position="29"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="391"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="400"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX74892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="538" mass="60732" checksum="81D1B985A78B577E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0F3</accession>
    <name>E9H0F3_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_108524</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732580">
        <property type="protein sequence ID" value="EFX74829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74829">
        <property type="protein sequence ID" value="EFX74829"/>
        <property type="gene ID" value="DAPPUDRAFT_108524"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_108524"/>
    <dbReference type="HOGENOM" id="CLU_1504976_0_0_1"/>
    <dbReference type="OMA" id="PLMQSHF"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="179" mass="17590" checksum="25E7895284708755" modified="2011-04-05" version="1">MAASCSASSYRTQQSAWGSQPAAAAPLPLQNGGGYGNKVWGSAPSASVQPTFGAPALVQDAPLAPAPAPAQSSFPATTQQICTCVAVPAAAQQQSAAPAPAAAAPLADVPLQQAAPQQTYSAPAAAPQQTWSAPAAAPAPVAPATQQFYSAPVQQAAAPAPVFRPAPSAAARPSYSTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0X6</accession>
    <name>E9H0X6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_226626</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732582">
        <property type="protein sequence ID" value="EFX74535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74535"/>
    <dbReference type="EnsemblMetazoa" id="EFX74535">
        <property type="protein sequence ID" value="EFX74535"/>
        <property type="gene ID" value="DAPPUDRAFT_226626"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_226626"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034705_1_0_1"/>
    <dbReference type="InParanoid" id="E9H0X6"/>
    <dbReference type="OMA" id="IGNFHIA"/>
    <dbReference type="OrthoDB" id="1318747at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030176">
        <property type="term" value="C:integral component of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030173">
        <property type="term" value="C:integral component of Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="PTHR10984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="ERGIC_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="COPIIcoated_ERV" evidence="7">
        <location>
            <begin position="147"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX74535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="381" mass="42879" checksum="A38D6A62CAA827D8" modified="2011-04-05" version="1">MIKNLGTAFKTIDAYPKTLEDFTIRTATGAMVTVFSSIIMAFLFVIEFRDFLSINVSEQLYVDTTRIPNMKINFDVTFPTISCSYLSVDAVDSSGEQQFGVEHNIFKQRLNLLGEPLQAAELEEINKTHNKTETSTEESASKPCNSCYGAKEGCCETCAEVREAYRQKNWAFRPEEFEQCRNEKNLTRDYSAFKEGCKLYGYLEVNRVSGSFHIAPGKSYAINHVHVHDVQPYSSEDFNVTHHINSLSFGTSLIGKENPLDGFLTTADKGAMMFQYYIKVVPTWYVKLDGEEFHTNQYSVTRHQKVVSSYGGESGVPGVFFTYEMSPLQISYKESKRSIGHFATDVCTIIGGVFTVAGIIDSLLYRSSKLLQQKLQLGKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9H175</accession>
    <name>E9H175_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_226732</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the urea transporter family.</text>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX73846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73846">
        <property type="protein sequence ID" value="EFX73846"/>
        <property type="gene ID" value="DAPPUDRAFT_324838"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_324838"/>
    <dbReference type="HOGENOM" id="CLU_790522_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX73846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="353" mass="39665" checksum="758648EF5A0F149C" modified="2011-04-05" version="1">MTNFEKVKMATSKSIRFLSSKRDSIVFLILLIVWTCLLFVFKKPDNQSDTVQIICNDKIYINHPMASPERIECKKFCLILGLIWSSLNFASIDFLNEWGKIKKKTTFLKFCYRPLLWIATLLTGSVLVWMWGNNRYYSERLAPNFLAACRPLDLFCSPDSIVRVKCTTPAGMWMPALSDSLPTVAAIQAYLMVITFVKMAHFVLLAVSNTQMEFRVASIVWGLVILVINVAVTLATACLIINCNDASVNIDFVSGYIKSAIVAGFWLLGEYYWRLSGIEDPKLPRYWNDPTPPQTGQNSTNLTSAPPTTSLDEPSAATGSATGETENAYQAIYPNLPPEDENPPSYEDLVTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9H463</accession>
    <name>E9H463_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_325252</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the arrestin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_325252"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_325252"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_384162_0_0_1"/>
    <dbReference type="InParanoid" id="E9H463"/>
    <dbReference type="OrthoDB" id="817924at2759"/>
    <dbReference type="PhylomeDB" id="E9H463"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="683"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="10">
        <location>
            <begin position="269"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX73492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="720" mass="80563" checksum="B8F09038B2600E04" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6S6</accession>
    <name>E9H6S6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DAPPUDRAFT_326119</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Postsynaptic cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX72561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72561"/>
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        <property type="protein sequence ID" value="EFX72561"/>
        <property type="gene ID" value="DAPPUDRAFT_326119"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326119"/>
    <dbReference type="eggNOG" id="KOG3645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018074_1_0_1"/>
    <dbReference type="InParanoid" id="E9H6S6"/>
    <dbReference type="OMA" id="WPSAATH"/>
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    <dbReference type="PhylomeDB" id="E9H6S6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated cation-selective channel activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005231">
        <property type="term" value="F:excitatory extracellular ligand-gated ion channel activity"/>
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    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:nervous system process"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
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        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
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        <property type="entry name" value="SSF63712"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF90112"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Neur_chan_LBD" evidence="21">
        <location>
            <begin position="52"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Neur_chan_memb" evidence="22">
        <location>
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            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX72561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="525" mass="60327" checksum="118C69FC7F6BF550" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9H7D4</accession>
    <name>E9H7D4_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_110860</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_110860"/>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="414"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9H854</accession>
    <name>E9H854_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_326573</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732603">
        <property type="protein sequence ID" value="EFX72087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72087">
        <property type="protein sequence ID" value="EFX72087"/>
        <property type="gene ID" value="DAPPUDRAFT_326573"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326573"/>
    <dbReference type="HOGENOM" id="CLU_092277_0_0_1"/>
    <dbReference type="OrthoDB" id="1598479at2759"/>
    <dbReference type="PhylomeDB" id="E9H854"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX72087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="294" mass="32836" checksum="FA1066CAD6FF0EBB" modified="2011-04-05" version="1">MASSVTDGIFWLVDLTAHEGPYVATVPDFWLIEGNTKCYYPRSRGDVAAMKREPVRSNWDIYGCKTRKSFNSYEESRSKENQATIQSDINSDSDSHTPMGRGHRSKRAPGRYLHSDLAQDERPLNVENDDDSVGMYGPTQNTAQQTFDTTPVFPPLLVSTGVSQLANNAANWNHQPFPYETTTDLHQNQVSSPFHAQRFGPGQPELNNRQGSQSSAVLEQVQHIRPVITPGLADQSNELSDGSKSVLTKLVKEVLKLTTQQQQHSNSRFTTPPSLQSITHKFMMPRATTPSFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9R1</accession>
    <name>E9H9R1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pept_C1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_216612</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732609">
        <property type="protein sequence ID" value="EFX71444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71444">
        <property type="protein sequence ID" value="EFX71444"/>
        <property type="gene ID" value="DAPPUDRAFT_216612"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_216612"/>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012184_8_1_1"/>
    <dbReference type="InParanoid" id="E9H9R1"/>
    <dbReference type="OMA" id="RMVPEND"/>
    <dbReference type="OrthoDB" id="1275401at2759"/>
    <dbReference type="PhylomeDB" id="E9H9R1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pept_C1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX71444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="205" mass="22316" checksum="D8429572F5547D9A" modified="2011-04-05" version="1">MPPVKFQAPCGGCWAFIATTAVEFQTCLKSANKTLLTLSEQQLIDCSGNYGTKGCNGGFYSQAWDYIMANGGQASNATYPYKAVVGNCSFVKDVTPTMGKISRYSFLAKNETAILAAVQKGPIAVSIVTNSNFTLYKSGIFDDDTCKNGTVNHGVLIVGYGRTNSTDYWIVRNSWGTSWGMSGYIFMKRNVNICRIAEYAFLATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9HAD6</accession>
    <name>E9HAD6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_255940</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732611">
        <property type="protein sequence ID" value="EFX71291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71291">
        <property type="protein sequence ID" value="EFX71291"/>
        <property type="gene ID" value="DAPPUDRAFT_255940"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_255940"/>
    <dbReference type="HOGENOM" id="CLU_694973_0_0_1"/>
    <dbReference type="OMA" id="PMKTQSK"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237946" evidence="2">
        <location>
            <begin position="22"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX71291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="397" mass="42676" checksum="0A2BD85474D6B349" modified="2011-04-05" version="1">MAKPEISKFLAPILLIALAFAIIESDISVSAESNLMGVYVDVAGDSLDGIEERFDFSRGKGKGHIGRRRPGKLRNKHKHTKSSYGVPKSQYEASKPYYPPSKAQSKPHGKYPPKTQYSLGPVYSYVAPAYNTPTYSLPVYSQSAHLRAPALRPQPSRPQSPRRPSPQASVAHASAPIRPSHLAPPQYTNSPSIHPQSALPTRPKTSSTTRPKTSPPTPPKISPASSPKTSHPTRPKTSPPTSPKTPPRPSSHRPTYPTTSLPTTTSPSTTTSTRVYSSPAPVSSTTATATSSPIDTSTSAYNSSTSDSSTSSAPESSSPKTESSQPKKKYAPPKKEMIIPLKLKNEVPIKPAYTPKTSPKGNSTSPVSISKDKDNEGFFSSPSEGFPNFFKQLLQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9HBH3</accession>
    <name>E9HBH3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_202030</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732616">
        <property type="protein sequence ID" value="EFX70917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70917"/>
    <dbReference type="EnsemblMetazoa" id="EFX70917">
        <property type="protein sequence ID" value="EFX70917"/>
        <property type="gene ID" value="DAPPUDRAFT_202030"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_202030"/>
    <dbReference type="eggNOG" id="KOG2643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027103_3_0_1"/>
    <dbReference type="InParanoid" id="E9HBH3"/>
    <dbReference type="OMA" id="ALGNIRQ"/>
    <dbReference type="OrthoDB" id="707988at2759"/>
    <dbReference type="PhylomeDB" id="E9HBH3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="PTHR12294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="260"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="452"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX70917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="518" mass="60092" checksum="39AC6840CB87E7D2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCG3</accession>
    <name>E9HCG3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_328080</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX70510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70510">
        <property type="protein sequence ID" value="EFX70510"/>
        <property type="gene ID" value="DAPPUDRAFT_328080"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_328080"/>
    <dbReference type="HOGENOM" id="CLU_934673_0_0_1"/>
    <dbReference type="OrthoDB" id="775399at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="298" mass="34124" checksum="969E55A09B9FE6BA" modified="2011-04-05" version="1">MAQYQLLHSIIICLRQSLNLQLTVSLDTDNIHNKLTKPANNTANDDNNFYVIDTSSKESQQKSHDENEEQEPLFECSMNNIHEFIESIEVESLDTQQEENLKSSIPEWIIENRVPVSHASSLLKILHHEAGLTFLSLDVRKLLGSLRTKVQTTDMRPGTLTEVEFRTKNFQVNKISWDFETQTNGVVLENVLQVIHANPVVEEYRVAMVDENLCQKYRSMCIEREDSMSNWFLESNVIDNSGIDPLLPGESKMDGSSVICRDLLKQVLLKLGRSKLKNPEHQILHYGKSPKMIEVSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCL0</accession>
    <name>E9HCL0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_228284</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732620">
        <property type="protein sequence ID" value="EFX70494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70494"/>
    <dbReference type="EnsemblMetazoa" id="EFX70494">
        <property type="protein sequence ID" value="EFX70494"/>
        <property type="gene ID" value="DAPPUDRAFT_228284"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_228284"/>
    <dbReference type="eggNOG" id="KOG0644">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="240778at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Arnold G.J."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Andrews J."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="244" mass="26058" checksum="D555BA83615E0930" modified="2011-04-05" version="1">MKAVCIAVLALAAFIVAEEPKETVVIAQDPKDEAVVVVEEPKEVRDMKALQQAYAFAIPYGYAAAPFGYAAAAPYGYTAVPAKFAATPFAYGANSAKFTATPYGNAYTAAPFYGYDAPYYGYTAPVTVGAAPVAFAVPAKFAAQTYPFAAAQAYPFVAAQTYPFGAAQTYPFGAAKQQQYAAYAPQYAGYQNTGFPYSYGYAPSAYSFKFRDSAKEQSASYLPENFPFAYPSYAFPGFPVAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGD6</accession>
    <name>E9HGD6_DAPPU</name>
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        <recommendedName>
            <fullName evidence="1">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="5">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732640">
        <property type="protein sequence ID" value="EFX69223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69223"/>
    <dbReference type="EnsemblMetazoa" id="EFX69223">
        <property type="protein sequence ID" value="EFX69223"/>
        <property type="gene ID" value="DAPPUDRAFT_301019"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301019"/>
    <dbReference type="eggNOG" id="KOG1613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_3_1_1"/>
    <dbReference type="InParanoid" id="E9HGD6"/>
    <dbReference type="OMA" id="RWILADP"/>
    <dbReference type="OrthoDB" id="1210090at2759"/>
    <dbReference type="PhylomeDB" id="E9HGD6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043928">
        <property type="term" value="P:exonucleolytic catabolism of deadenylated mRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071042">
        <property type="term" value="P:nuclear polyadenylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:nuclear polyadenylation-dependent tRNA catabolic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034427">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033196">
        <property type="entry name" value="Rrp43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="PTHR11097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="2">
        <location>
            <begin position="31"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="3">
        <location>
            <begin position="193"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX69223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="276" mass="30161" checksum="A4A1557CC0BD8D85" modified="2011-04-05" version="1">MATDHKTLQPLEFYKTFLDRKSRPDGRKLLEFRKMTLNAGSIGTADGSAIVKCGNTTVICGIKAELAAPEREEPSKGFIIPNVTLPSLCSSQIKSGPPGETAQAATQFIAELVNNNIIMDLETLCIKVSKWAWVLHCDLLCINLDGSLLDACVMALVAALKNLKLPIVSYDEEMDKLISNPDEKMGFDTIKQPVTSTFSLFDNGILISDPTFEEEQLAAGLTSITMEGTSVTHMYKPGGCTLDEKQVKKLIQQSELKTKEVARLIEEACSSSIAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJ53</accession>
    <name>E9HJ53_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_93620</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732660">
        <property type="protein sequence ID" value="EFX68182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68182"/>
    <dbReference type="EnsemblMetazoa" id="EFX68182">
        <property type="protein sequence ID" value="EFX68182"/>
        <property type="gene ID" value="DAPPUDRAFT_93620"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_93620"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_5_1"/>
    <dbReference type="InParanoid" id="E9HJ53"/>
    <dbReference type="OMA" id="MFILASR"/>
    <dbReference type="OrthoDB" id="921996at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="296" mass="33162" checksum="C1AA12E2D2C44EEA" modified="2011-04-05" version="1" fragment="single">PRCTNVVRLDGKVAVITGANTGIGKETARELSRRGAQVVIACRDIQKAEDAAREISSETKNSVTTLKLDLASLSSIRTAAQNLKVQQPKIHLLINNAGIMVCPQWKTEDDFEMQLGVNHLGHFLWTLMLLDNVKQAAPSRIINVSSIAHTRGNIDFDDIMMEKNYDPTRSYCRSKLANVLFSKELANRLNGTGVTCYSLHPGVVQTELGRHLRVTTNRLVDDMFHWFGQYFFKTPEMGAQTTIYCATEPSLSSRTGLYYSDCAEERPARQAENKEAARRLWEISEKLVNFSYGSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKD9</accession>
    <name>E9HKD9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_203591</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732668">
        <property type="protein sequence ID" value="EFX67799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67799"/>
    <dbReference type="EnsemblMetazoa" id="EFX67799">
        <property type="protein sequence ID" value="EFX67799"/>
        <property type="gene ID" value="DAPPUDRAFT_203591"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_203591"/>
    <dbReference type="eggNOG" id="ENOG502RYFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074449_1_0_1"/>
    <dbReference type="InParanoid" id="E9HKD9"/>
    <dbReference type="OMA" id="CTNELSL"/>
    <dbReference type="OrthoDB" id="1080106at2759"/>
    <dbReference type="PhylomeDB" id="E9HKD9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016697">
        <property type="entry name" value="Aquaporin_11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031145">
        <property type="entry name" value="Invert_Aqp-10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191:SF16">
        <property type="entry name" value="PTHR21191:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017529">
        <property type="entry name" value="Aquaporin_11/12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241997" evidence="6">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX67799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="260" mass="28542" checksum="46CBB4A8BBABA6C9" modified="2011-04-05" version="1">MAAALIASCLLIAASCLSSELLRIIINKNVETPLSKLLCLEFIASAELCAVCFELIVVAEEYGIWMYALVLFLLTLWWAAHWGDASACPYIHLEAYLDGSIHFSQAFLASLAEIAGGLAIYKYVQYTWDLELSGHINRSVWDCDADLHVPAFQGALIEGVATFLCRIVSKLIAEIEPRFGGVLDAFIGTSLVVAACDYSGGYFNPVLATSLKLNCRGNTVAEHFVVYWIGSIAGSVVSWRVYPFIKENLFPKPSTNKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKR6</accession>
    <name>E9HKR6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_330831</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732671">
        <property type="protein sequence ID" value="EFX67652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67652">
        <property type="protein sequence ID" value="EFX67652"/>
        <property type="gene ID" value="DAPPUDRAFT_330831"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330831"/>
    <dbReference type="HOGENOM" id="CLU_1355866_0_0_1"/>
    <dbReference type="OrthoDB" id="350373at2759"/>
    <dbReference type="PhylomeDB" id="E9HKR6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="202" mass="22782" checksum="37701568DA0FCD1D" modified="2011-04-05" version="1">MSTFKHTSSKELYGGNSQISIAAIDSPESNIRSFDPKLRLKLKCLRSAVLDKSTDIDFHPLAAYTGELFGIEYLYSEMGSNLTLGVNIDIEIEEGLNDDDDFFTFFPEEEDCLDSELDVDVLNDDCLDSELDVAVLSFMIDEEDNSEEDQFLDFNSIEGWDKVVELMKLLVDIKSLSISTLDAEKIVQSYNNLSPYDKKPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKX9</accession>
    <name>E9HKX9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_63809</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732673">
        <property type="protein sequence ID" value="EFX67613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67613"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_63809"/>
    <dbReference type="eggNOG" id="KOG2774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_19_1_1"/>
    <dbReference type="InParanoid" id="E9HKX9"/>
    <dbReference type="OMA" id="HWHASPR"/>
    <dbReference type="OrthoDB" id="1327602at2759"/>
    <dbReference type="PhylomeDB" id="E9HKX9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="307" mass="34838" checksum="3D35052FA5CA5D0D" modified="2011-04-05" version="1" fragment="single">GGLGQLGTGLAKVLRQKYGKNNVIMSDILKPSKEVVESGPYIFADILDFKCLQEMVVNNRIDWIIHFSALLSAVGEQNVPLAIRVNIEGLHNVMELAKQYRLRIFVPSTIGAFGPESPRNPTPNLCIQRPKTIYGVSKVHGELLGEYYYHKFGLDFRCLRFPGVISSDTNPGGGTTDYAVQIFHDALKTRQFQCYLKPDTRLPMMYITDALRSLCEFMALPPEALKQRTYNVTAMSFTPEEIVKSVQRHVPDLQVSYAPDSRQQIADSWPQVFDDSEARAEWNWKPQYDIDGMVDIMVEALRPKYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLF3</accession>
    <name>E9HLF3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_261672</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732678">
        <property type="protein sequence ID" value="EFX67443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67443"/>
    <dbReference type="EnsemblMetazoa" id="EFX67443">
        <property type="protein sequence ID" value="EFX67443"/>
        <property type="gene ID" value="DAPPUDRAFT_261672"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_261672"/>
    <dbReference type="eggNOG" id="KOG0724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1005633_0_0_1"/>
    <dbReference type="InParanoid" id="E9HLF3"/>
    <dbReference type="OrthoDB" id="1499953at2759"/>
    <dbReference type="PhylomeDB" id="E9HLF3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="196"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX67443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="277" mass="32245" checksum="FCA23DEED73A997E" modified="2011-04-05" version="1">MKKLQKEIKKKKLKTNEVEIEEKLDKLYVIPKPSYKNTLPIQIFNMIISLPVAIRWLVKYKEEKRKEAEAKKEQDRLDAEEEELIKEEMEREKEMKKSYRRKRAAPLPSYSGAAEERVFEVAVDAASQGEEKPVVPLNTGPWTDEDLTELAKLMKKYPVGTTERWEKIAEALNRSVTEANYGIEGVEEQTPGSCGWTQKQQKSLETALACYTKGCSERWERIAKAVPDKTKEECMMRLKYLSDLVKKKKHMEEEKLRAEQEPTQLNEKQDSETIQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9HMM9</accession>
    <name>E9HMM9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_115821</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732688">
        <property type="protein sequence ID" value="EFX66997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66997">
        <property type="protein sequence ID" value="EFX66997"/>
        <property type="gene ID" value="DAPPUDRAFT_115821"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_115821"/>
    <dbReference type="HOGENOM" id="CLU_1190905_0_0_1"/>
    <dbReference type="OrthoDB" id="1530921at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="MULE" evidence="3">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX66997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="233" mass="26919" checksum="4F94B81AF96650C2" modified="2011-04-05" version="1">MHVLYSNFANFGVGQPVAFFCWTEETEKMISTELKYFCDNNDNSITEVVFTDKDCAEITAIAQLFPHSTQLLCHFHVLRALDRYLKRLEDGNLGNYFDTFWFSDKCVKKWPMKERRGLCKLGNHTFQTGTSLEKSSDTSYMAQIINILSDEDKLIKSITFLVSFGLVKIIVWLYVDEQLKRRKSRRDEENEKEETKMNDPPTPQVPNPPCVVVISENQSSTSRGTTTTTTRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9HND7</accession>
    <name>E9HND7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_262644</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732695">
        <property type="protein sequence ID" value="EFX66765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66765"/>
    <dbReference type="EnsemblMetazoa" id="EFX66765">
        <property type="protein sequence ID" value="EFX66765"/>
        <property type="gene ID" value="DAPPUDRAFT_262644"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_262644"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_7_1_1"/>
    <dbReference type="InParanoid" id="E9HND7"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="PhylomeDB" id="E9HND7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003238467" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="39"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX66765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="342" mass="35429" checksum="346216F68DD65D80" modified="2011-04-05" version="1">MRFTLLALSVFVLIGFVHSNSLPNLFQRNSEADQPTISIVGGVPAAAGEFPYLAILSLGQFLCGGSLIGQSHILTAAHCVQGFTAADVSTFFADINTLSIDGGGTGAVFRGVKKFIIHPSYNTKTQDNDVAMLILNSPVTTVKFVALPSDNPTTLAPTTIKTTTTLKSNATTPKLTTTTPKPTTAKSVTTAKATVSTTKMPCSCTCAPTTTPVVANGQTTKKTALLRAFSTYANQVATIAGWGTTSLGGSLSNVLLKATVTIQDNTVCASQYGNFVGADMLCASAPGKDTCQGDSGGPILVNGVQVGITSYGNGCADPKYAGVYTRVSNYVSWIQTTMANNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNT2</accession>
    <name>E9HNT2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_331912</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0371">Homeobox</keyword>
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    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="13">
        <location>
            <begin position="18"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="216"/>
            <end position="265"/>
        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="189"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="265" mass="29028" checksum="AE86F03747A68F05" modified="2011-04-05" version="1">MTNPLGIRPLLGGYPFQGQGRVNQLGGVFINGRPLPNHIRLKIVELAAAGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPKSSSSGSSGITTPAGGSNEVERKMDDYRRDNPNIFSWEIRDRLIKDGICDKSSAPSVSSISRLLRGPRGGEGHGSDDCGSSIDGHISADPHRPQHDHTINGILAGRSSEDEDSSDIESEPGIALKRKQRRSRTTFSADQLEELERAFERSQYPDVYTREELAQKTRLTEARVQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HVV1</accession>
    <name>E9HVV1_DAPPU</name>
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        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="198" mass="21847" checksum="B0434E15DCF75929" modified="2011-04-05" version="1">MSSESGKRATDVFDKLYLVVQQSEREIGKYGGQNHHGYLLKPLVVGKYASSSGARASLSAMSTPTNQQMKDMATLNMLPEYIVNAYCLGDVVLIAMNQPTNICIGHQDFLFEQGIPLAAFFFYCRGFNSLHGKTVSNETMLLATDLRSAILSISQRVNQAPQGRNKIKVDHALTASQSSMQWSKFVGIVPIFGKFSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HXC1</accession>
    <name>E9HXC1_DAPPU</name>
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    <organism evidence="2">
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733026">
        <property type="protein sequence ID" value="EFX63609.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_335276"/>
    <dbReference type="HOGENOM" id="CLU_109521_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HXC1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX63609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="163" mass="19105" checksum="EA3C7ECC1847C029" modified="2011-04-05" version="1">MCQRLKTYGEYFMVQQCTAVNISVGMKETRCGPEPIYKDFTVGKDGFSLHPFEECFWPNKVVNLNGQTHMWKDAEWTPMHPSSHLSTLRLTAKFKELEDNEAQYVINSHDIFNRPEYEAVNSVNEIVSRIHESNSKNLSAIIVNEHEESRHWDLRRWTSKLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZV6</accession>
    <name>E9HZV6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_336533</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kriventseva E.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
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                <person name="Geiler-Samerotte K.A."/>
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    </dbReference>
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    <dbReference type="PhylomeDB" id="E9I4W6"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <sequence length="245" mass="28375" checksum="0E57A13B0304D746" modified="2011-04-05" version="1">MEFVTARNDSFQYNAIYAKELKKNDKYKKYYATEGGPRLIYGEIGGTSQTYLSWRPKKAMPNSGSEKTPVEISEILISIVTEKKDTFIYEYEGKYGYSLDEKTLYTLLKKTEKNKYDDPCKTKYKLKEIDFSESNVSNLYSLLFKFNFEEKSDVPELVDMVVELKNCEGTAQYIKIALKYDAKSETYIGSQTIAQIQNCRWEIKSGLISAYNSCKEKTVWSFDTSKVKERGGRTIILDIRIRADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9I813</accession>
    <name>E9I813_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_126468</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL737677">
        <property type="protein sequence ID" value="EFX59867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX59867">
        <property type="protein sequence ID" value="EFX59867"/>
        <property type="gene ID" value="DAPPUDRAFT_126468"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_126468"/>
    <dbReference type="HOGENOM" id="CLU_1954160_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX59867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="129" mass="14475" checksum="06DEEA1C8E3D2204" modified="2011-04-05" version="1" fragment="single">VPPATLLERLSELERDRASTKRMQQEYTLKEQALEASALSLRKRSLEDAISEPEIDKAKVNAILRQIFRRVVISRNGQTLGFEWQHSDSMTPVHYAKSGKNTVGYLLSTPKPIAVPPLPSAPNIPKLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9FS67</accession>
    <name>E9FS67_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldo_ket_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_300057</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX89979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89979"/>
    <dbReference type="EnsemblMetazoa" id="EFX89979">
        <property type="protein sequence ID" value="EFX89979"/>
        <property type="gene ID" value="DAPPUDRAFT_300057"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300057"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="E9FS67"/>
    <dbReference type="OMA" id="NTEMIPC"/>
    <dbReference type="OrthoDB" id="1016440at2759"/>
    <dbReference type="PhylomeDB" id="E9FS67"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:alditol:NADP+ 1-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="24"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX89979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="316" mass="36150" checksum="9BD6F0C2563F794E" modified="2011-04-05" version="1">MNIKIPTVPLNNGYEMPIMGFGTYSATPEEFTRMISDAINAGYRHIDGAMFYGNEVDVGNGIRQKIEEKIVTREELFLVSKLWPTFMSPHLVEPTLRQTLKDLQTDYLDLYLIHWPTALEENMGLIPKDKDGNLIFKNVDFVNTWKALENCVSQGLVRSIGISNFNSQQINRLMKHCTIKPVTNQIEVHAYLNQKKLIELCRQHDMIVTSYGPLGRPGFQKDASEPVLILDPKVIELSEKYGRTPAQIVLRYLTMQNIPVIPKSSTKARIEENLASLEFDLTPPDMAALDSLDCGYRNNKWEWAINHPEYPFSLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSS7</accession>
    <name>E9FSS7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_26682</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89770"/>
    <dbReference type="EnsemblMetazoa" id="EFX89770">
        <property type="protein sequence ID" value="EFX89770"/>
        <property type="gene ID" value="DAPPUDRAFT_26682"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_26682"/>
    <dbReference type="eggNOG" id="KOG1166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1673597_0_0_1"/>
    <dbReference type="InParanoid" id="E9FSS7"/>
    <dbReference type="OMA" id="FYELIAI"/>
    <dbReference type="OrthoDB" id="1411806at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="PTHR14030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="158" mass="18210" checksum="FF7F1BFF77A3E217" modified="2011-04-05" version="1" fragment="single">YFYDSGSILVYQYPSHGTLLDLINSYKLKNTSMPESLVYHFSLQLLSIVSDMHECGILHADIKPDNILLQSSLTSILHSFENWTVEEVLALDKRSLKLIDFGRSIDLALYPDRTAFMHVFQDDKCPEMRDGKPWSYQLDYYGLATSIYTMLMGVHCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUH9</accession>
    <name>E9FUH9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_191301</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88732"/>
    <dbReference type="EnsemblMetazoa" id="EFX88732">
        <property type="protein sequence ID" value="EFX88732"/>
        <property type="gene ID" value="DAPPUDRAFT_191301"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_191301"/>
    <dbReference type="eggNOG" id="KOG1460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_3_0_1"/>
    <dbReference type="InParanoid" id="E9FUH9"/>
    <dbReference type="OMA" id="MPVPNWW"/>
    <dbReference type="OrthoDB" id="806744at2759"/>
    <dbReference type="PhylomeDB" id="E9FUH9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="422" mass="47612" checksum="79155EE7C320802A" modified="2011-04-05" version="1">MLVKAVILIGGNQKGTRFRPLSLDLPKPLFAVAGFPIIQHHIEACVQIPFLKEIIILGYYGANEMSQFVGEMVQLYKLNIRYLQEFEPLGTAGGLYHFRDQIRCGNPDYFFVLNGDVCADFPLIEMLEFHKTHREKQKAIVTLMATEATRQQSLIYGCIIENKENNTLEHYVEKPSTFISTLVNCGVYIFSPEVFQQMANVFNKKQMDFYNVENGSSVEREALYLEKEILMPLAGTGKALIYQTLKWWSQLKTPGAAIYANRHYLNLFRERRPERLAKSDQPTIIGDVYIHPTADVHPTAVLGPNVSIGAHATISYGTRIKESIVLAHSRVLDHSLVLYSIIGANSEIGCWSRVEGTPCDPNPDKPFAKMENAPLFNDEGRLNPSITILGNNVTIPSEVIVRNSIVLPHKELTRSYNNEIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUX0</accession>
    <name>E9FUX0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Guanine nucleotide binding protein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Gnb1</name>
        <name evidence="6" type="ORF">DAPPUDRAFT_206575</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88843"/>
    <dbReference type="EnsemblMetazoa" id="EFX88843">
        <property type="protein sequence ID" value="EFX88843"/>
        <property type="gene ID" value="DAPPUDRAFT_206575"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_206575"/>
    <dbReference type="eggNOG" id="KOG0286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_34_1"/>
    <dbReference type="InParanoid" id="E9FUX0"/>
    <dbReference type="OMA" id="WQITANI"/>
    <dbReference type="OrthoDB" id="704786at2759"/>
    <dbReference type="PhylomeDB" id="E9FUX0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030159">
        <property type="term" value="F:signaling receptor complex adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="Gprotein_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="Guanine_nucleotide-bd_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="PTHR19850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX88843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="340" mass="37327" checksum="D7084827708437B8" modified="2011-04-05" version="1">MNELDSLRQEAEALKNAIRDARKSACDTTLVQATANMEAIGRIQMRTRRTLRGHLAKIYAMHWGTDSRNLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIVTSSGDMTCALWDIETGQQTTSFTGHTGDVMSLSLSPDMRTFVSGACDASAKLWDVRDGMCRQTFSGHESDINAIGFFPNGYAFATGSDDATCRLFDIRADQELAMYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDSMRTERAGVLAGHDNRVSCLGVTEDGMAVATGSWDSFLKIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E9FWK6</accession>
    <name>E9FWK6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CAF1C_H4-bd domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_311335</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_311335"/>
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    <dbReference type="eggNOG" id="KOG0302">
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    <dbReference type="PhylomeDB" id="E9FWK6"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
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    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4_N"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
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            <end position="35"/>
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            <begin position="143"/>
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        </source>
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        </source>
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        <source>
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        </source>
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    <sequence length="471" mass="52685" checksum="00E11750D4480B40" modified="2011-04-05" version="1">MWSNAVGCCEFHFYGFFIMNISVCFLEKSGIVWSWHGDSCANALSMMEEGLPSTFFSILIFATHAHLASLLLNTIVRRRRCGFVCAIPRRHRYTSGAPCLSFDIIPDGLGSERTDFPHTAYLLSGTQASTDFTNRLIVMKMSNMQKTQPESDSEDSDDDDDENVMKPDLECAIIHHQGSVNRVRMCVVGDKPLAASWSETGKVFLWDLTHPLKAVNDPILLRNYVENKESPRPLFTFKGHTTEGFAMDWSTPMPGVLATGDCKKNIHIWKPSEGGLWAVDQRPLIGHDASVEDLQWSPNEPNVLASCSVDRSIRIWDTRVQPSKACMLAAINAHENDINVINWNKKEPFILSGGDDGKLHVWDLRQFQSSTPVATFKHHTAPITSVEWHPTDSTVFASAGADDQIALWDLALEKDEETAIVDPELADLAPQLLFIHQGQKEIKELHWHPQIPGMIISTAITGFNIFKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYH6</accession>
    <name>E9FYH6_DAPPU</name>
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        <recommendedName>
            <fullName evidence="8">Peroxin-5</fullName>
        </recommendedName>
    </protein>
    <gene>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
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        <property type="match status" value="3"/>
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    <proteinExistence type="inferred from homology"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="622" mass="69698" checksum="40A5DB219237EC60" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9G305</accession>
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            <fullName evidence="14">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="14">LTA-4 hydrolase</shortName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LTA4</name>
        <name evidence="16" type="ORF">DAPPUDRAFT_313156</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>H2O + leukotriene A4 = leukotriene B4</text>
            <dbReference type="Rhea" id="RHEA:22324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57461"/>
            <dbReference type="ChEBI" id="CHEBI:57463"/>
            <dbReference type="EC" id="3.3.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; leukotriene B4 biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.6" evidence="14"/>
    <dbReference type="EMBL" id="GL732530">
        <property type="protein sequence ID" value="EFX86132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86132"/>
    <dbReference type="MEROPS" id="M01.004"/>
    <dbReference type="EnsemblMetazoa" id="EFX86132">
        <property type="protein sequence ID" value="EFX86132"/>
        <property type="gene ID" value="DAPPUDRAFT_313156"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_313156"/>
    <dbReference type="eggNOG" id="KOG1047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014505_1_2_1"/>
    <dbReference type="InParanoid" id="E9G305"/>
    <dbReference type="OMA" id="YHPICRQ"/>
    <dbReference type="OrthoDB" id="775595at2759"/>
    <dbReference type="PhylomeDB" id="E9G305"/>
    <dbReference type="UniPathway" id="UPA00878"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004463">
        <property type="term" value="F:leukotriene-A4 hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019370">
        <property type="term" value="P:leukotriene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="PTHR45726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 14" id="KW-0434">Leukotriene biosynthesis</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Leuk-A4-hydro_C" evidence="15">
        <location>
            <begin position="467"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="12">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="12">
        <location>
            <begin position="268"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="12">
        <location>
            <begin position="570"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFX86132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="618" mass="69540" checksum="CBE370CFCB769C6C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9G311</accession>
    <name>E9G311_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_97949</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732530">
        <property type="protein sequence ID" value="EFX86410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86410">
        <property type="protein sequence ID" value="EFX86410"/>
        <property type="gene ID" value="DAPPUDRAFT_97949"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_97949"/>
    <dbReference type="HOGENOM" id="CLU_1435792_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX86410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="189" mass="21362" checksum="D588C7496766781D" modified="2011-04-05" version="1">MDARRLLGAQQQHQQRPPRSWPADNQEAEHQGRPLLLQRHKERARNKRAAVNGGICSGADPSGVPRWRPSLTFFPGWSRRCPPIEGHCWWWQDNARRARPLRPVPRPVVSRLLSGAHHRTARVIVSVVFIRSSSPPISSSQRDLFLLTAEKDQTDCVHLPECPSQLIDSLVCPSVCCLPDPARPVCRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3G3</accession>
    <name>E9G3G3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_237248</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Thomas W.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
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                <person name="Jogdeo S."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
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                <person name="Shaw J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="eggNOG" id="KOG1471">
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    <dbReference type="GO" id="GO:0005737">
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    </evidence>
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        <source>
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    <sequence length="314" mass="36074" checksum="865E17FD6F6A9D33" modified="2011-04-05" version="1">MEWRHQHKINTLLDDFTPPEVLAKYFSAGYTGVDKLNSSLLITRFGAMDLKGMLLSAKKRDYLMTVVEVMTVIFDMAGFSMRHITFKPVAVETTLQLLQISESKYPELLRCVFVINAQDFAILYSMMKPFMHEKTKNKVQIYSHDSSIWKAALLAEIDRDQLPVCYGGTMTDPDGNLNCVTKVGMGGEVPRSYYLDAKPDPTNKKTFTVSRGSKEQLEIQIKQAGAILKWDFYTEEGDLAFAVYRKKDDELIPIVSHDRIDCDVSPEEGEIRCDYTGVYVVEFDNSYSYFRSKKIWFSITVYNERIENTEPFQP</sequence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kultz D."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
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                <person name="Robertson H.M."/>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="278" mass="30844" checksum="025AB3347C678F7E" modified="2011-04-05" version="1">MNFKLSQCCCGFSLRAGTIIIGIVDMFTGITVFIGAAISISGLSIDDGDHMRFYIYMGQMIGYGCMIFATVPVLIAAWKNRKPNLLSPWLVIEFLSLVTAVIYWFYLGILVYILKQGAFYNGTSFILDACIGVNKCVEQATSIGVIIGRAINISIFRPISLNDDIMYYYLCIGHAVLSMLTTALVLFSTWKNRMPRLLLPWLVMQITALIALCSFLLFWAVVFIAAGIPTGIGNILAACAVGALGFYFWLVVLSYYQELKVKAMIEQQETEKGAEQFS</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <end position="51"/>
        </location>
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        <source>
            <dbReference type="Pfam" id="PF14952"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="549" mass="61998" checksum="E0ACBA492CB9E60F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
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    </protein>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EFX83918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="61" mass="6997" checksum="2C8B4BED8F1DC896" modified="2011-04-05" version="1">MKPLDPCVAVCPILNVLRRLFTFDSTSQEKELEADSKFGRRRWTPAKRAMTIGSQMKIVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDL6</accession>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
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    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Smith Z."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Ye Y."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX82458"/>
    <dbReference type="EnsemblMetazoa" id="EFX82458">
        <property type="protein sequence ID" value="EFX82458"/>
        <property type="gene ID" value="DAPPUDRAFT_316658"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_316658"/>
    <dbReference type="eggNOG" id="KOG0753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_2_1"/>
    <dbReference type="InParanoid" id="E9GDL6"/>
    <dbReference type="OMA" id="VWSNIIC"/>
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    <dbReference type="PhylomeDB" id="E9GDL6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015131">
        <property type="term" value="F:oxaloacetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
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                <person name="Robertson H.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="156" mass="17708" checksum="E545D870C46F70E9" modified="2011-04-05" version="1">MKEIPLSAEPGAKRRKDRLSVPDEIRFSQVGIHHPIFVENRGRCEWCQATTERRPNGHTKESRPFSQCSMCKIFLCLSKKRNCFLEFHDDRILDPTKAAAETVLAVDPEEEIAVQTVETDPLGIYPSSDSSDDSDFDALNNDVNDGVLLDEDEWVK</sequence>
</entry>
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    <name>E9GFN7_DAPPU</name>
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    <organism evidence="3">
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        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732542">
        <property type="protein sequence ID" value="EFX81774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81774"/>
    <dbReference type="EnsemblMetazoa" id="EFX81774">
        <property type="protein sequence ID" value="EFX81774"/>
        <property type="gene ID" value="DAPPUDRAFT_211157"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_211157"/>
    <dbReference type="eggNOG" id="KOG2345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_109_2_1"/>
    <dbReference type="InParanoid" id="E9GFN7"/>
    <dbReference type="OMA" id="MHQYKVK"/>
    <dbReference type="OrthoDB" id="831026at2759"/>
    <dbReference type="PhylomeDB" id="E9GFN7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="307" mass="34258" checksum="6F6ABBA1AE2E49C5" modified="2011-04-05" version="1">MLQRIFSVFCSREYYDIDGKRYFVRELIGQGGFSTVDLVSEASSDRLYALKKIRCHSTEDEQAAEQEIRYHKQINHPSVIECLAFRTVGSADISSNQTSLVLLLLPFYKYGSLQTLLEKRLLKKEPLSDKLILNYFQQICEGLAAIHVIGVAHRDLKPANVLLAPNDRVVIMDLGSAAPATVEITSYNAAQRLQDDAAERCSMTYRAPELFNIQSPSTIDERTDIWSLGCLLYALCYYKSPFDEVFERGDSVALAASSGMNHFPNSTTPGVNSSLNDLISTMLVVDPKERPFIADVLSSIEALKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9GGR5</accession>
    <name>E9GGR5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_317709</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFT56 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732543">
        <property type="protein sequence ID" value="EFX81433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81433"/>
    <dbReference type="EnsemblMetazoa" id="EFX81433">
        <property type="protein sequence ID" value="EFX81433"/>
        <property type="gene ID" value="DAPPUDRAFT_317709"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_317709"/>
    <dbReference type="eggNOG" id="KOG3785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036306_0_0_1"/>
    <dbReference type="InParanoid" id="E9GGR5"/>
    <dbReference type="OMA" id="LMDISSC"/>
    <dbReference type="OrthoDB" id="383516at2759"/>
    <dbReference type="PhylomeDB" id="E9GGR5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035720">
        <property type="term" value="P:intraciliary anterograde transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030511">
        <property type="entry name" value="TTC26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781">
        <property type="entry name" value="PTHR14781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX81433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="369" mass="42122" checksum="D52FB1BCED3143FD" modified="2011-04-05" version="1">MALHVYIALCYYKLDFYDVSQEVLSVYLQKIPDSLIALNLKACNIYRLYNGRSAETEIRSLLESQVNCPFGKDLLNHNLVIFRNGDGALQVLPPLVGVIPEAKLNLIIYYLRQDETKEAFDLMQDVNPSLPAEYILKGIVYALIGQETNNKEYLDTAIQYLHLVGGSSSECDTIPGRQCVASAFFLQRQYEDVLLYFNSIKSYLSNDDTFKFNLAQVQTILGHYKEAEEELVTIQSAKYRSEYNYIECLTRCLVMNRKAVQAWEIYSRMETSAESLGILHLLANDCYRTGQFYIASKAFDVLDKYDPNPEHAAAKRGACVGLLQMVLAGREHREALSEVVNLMRGSPDPQMDHILRVINTWAKENRMKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GHH8</accession>
    <name>E9GHH8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_242849</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732545">
        <property type="protein sequence ID" value="EFX81059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81059">
        <property type="protein sequence ID" value="EFX81059"/>
        <property type="gene ID" value="DAPPUDRAFT_242849"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_242849"/>
    <dbReference type="HOGENOM" id="CLU_3034478_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="55" mass="5975" checksum="35641F2AF8D6924D" modified="2011-04-05" version="1">MSDGHMENGCLGFLSEFVICWPVALAELLMLCRKRSQPTVTTTDGQMKGNASNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9GHP2</accession>
    <name>E9GHP2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_211493</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="GL732545">
        <property type="protein sequence ID" value="EFX81017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81017"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_211493"/>
    <dbReference type="eggNOG" id="KOG2287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036849_2_3_1"/>
    <dbReference type="InParanoid" id="E9GHP2"/>
    <dbReference type="OMA" id="INDEHCE"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="PhylomeDB" id="E9GHP2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX81017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="271" mass="31220" checksum="1661D3EC1EFC6400" modified="2011-04-05" version="1" fragment="single">LLIVVISAVENFARRDLIRQTWASPHFVGVDWIQIIFLVGTTLRQDQIVQERLQKENVEHEDLVQVNVVDSYANLTLKSIALLHWAHGHCPGAQLVFKCDDDNYINWNVLSKILPNLNDTRSIYGTPVPTLYAERWKKQKHYVSRRVWPWPRYPNYLLGGCYAIAGQAVKPLLAATQTTPFFWIEDIYLTGLCASKVNVSLQSQPKYYYPDFPEKGQLNACFVRTTAIWQTRSLKHLAKSHKITSKVYSHELPCIPKSSRPVSKCFWGIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9GHV4</accession>
    <name>E9GHV4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein SHQ1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_303683</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732545">
        <property type="protein sequence ID" value="EFX80983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80983"/>
    <dbReference type="EnsemblMetazoa" id="EFX80983">
        <property type="protein sequence ID" value="EFX80983"/>
        <property type="gene ID" value="DAPPUDRAFT_303683"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303683"/>
    <dbReference type="eggNOG" id="KOG3247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030217_0_0_1"/>
    <dbReference type="InParanoid" id="E9GHV4"/>
    <dbReference type="OMA" id="NDWQLPQ"/>
    <dbReference type="OrthoDB" id="879404at2759"/>
    <dbReference type="PhylomeDB" id="E9GHV4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PTHR12967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX80983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="469" mass="53617" checksum="B7C42E7B53549B34" modified="2011-04-05" version="1">MITPRFKLSQDENCLFVTIHAPFSKVSDAEIYMDGTDFRFHSNPYYIRLNLPGEIIENDEAKANFDAETNEFKITCPKVIRGTHFQGLDMLTSLLAPKGKRSVDSKGIEVLEETCSEEDSESDFDWFLEQKIEEESSDLPANGSKYGFGLKHSGLFATLAEELHQVVDVKNPDNQSASERRIERLEQEKKEFNPEHYLADFFQTDMIDPLIEYVPSSRIGEEWTEAETILLKTLTNKEYLLDHDQLQSTYLGLVDILLAYCYDMRTTMSDPNVESAWTIAKISGTLSWLEIFTSIRQVVDCFLRRSLCFPLFRNFKLSIKAIEDASNILKEGRTSVLRCFLQIHQLFNKSDPRYLLNQLYIRDYCIWIQKSNDETLASLSQSLKSMEFTKEDVTLNLVDLERAAVNLMCYSDDSSEESDLEEQMAHLSLKKKSASSAMPIDLQVAAEAARMSSESDLDSDDDSSSEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9GI69</accession>
    <name>E9GI69_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_103026</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732546">
        <property type="protein sequence ID" value="EFX80627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80627">
        <property type="protein sequence ID" value="EFX80627"/>
        <property type="gene ID" value="DAPPUDRAFT_103026"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_103026"/>
    <dbReference type="eggNOG" id="ENOG502S7ZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062907_1_0_1"/>
    <dbReference type="InParanoid" id="E9GI69"/>
    <dbReference type="OMA" id="EEYANTH"/>
    <dbReference type="OrthoDB" id="1384033at2759"/>
    <dbReference type="PhylomeDB" id="E9GI69"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="83"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="266" mass="30571" checksum="3FD62DA0C4468023" modified="2011-04-05" version="1">MLKDPVAINLSLPVSTEEYANTHRLQQDHPCVLDLIRKNYLKKPWGPEVPFDLHNPKTADPSAGQAKAIMRILRNQANGFFVECGASDGEFLSNTLYMERYKNWTGLLIEPDRGSYDSLLTRKRKATHVPACLSLETYPTEVTFKSVFQVGSIQEKSSWFENDHLITVQCFPFYSFLLAYGRTSVDFFSLDVEGHELKILKTIPWHKVDIKTLVVEWEHVEEGEAGIVKFMEENGFVNFGKIATPYARDIVFVKDFLSDLRYDYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJL5</accession>
    <name>E9GJL5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_318747</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732548">
        <property type="protein sequence ID" value="EFX80131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80131"/>
    <dbReference type="EnsemblMetazoa" id="EFX80131">
        <property type="protein sequence ID" value="EFX80131"/>
        <property type="gene ID" value="DAPPUDRAFT_318747"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_318747"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_724152_0_0_1"/>
    <dbReference type="InParanoid" id="E9GJL5"/>
    <dbReference type="OrthoDB" id="80253at2759"/>
    <dbReference type="PhylomeDB" id="E9GJL5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="151"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="219"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX80131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="382" mass="42797" checksum="1507944F1A672814" modified="2011-04-05" version="1">MPYLEHKTDVLLAFDILTTAQPLIKARNFMELTDEELLDYQVMDRTIDRHISAVNVAIYPVEDGKFGKYAVAKDLLNLLIEKKKSIKVNFRDADSVQIANNDSGISMEDSFMAPVGFDGCRNKFCQDCRNTYTYYCNTVACILKQKKIEVVDVALSKRDCLVIMPTGSGKSACFLLPGLVERGITVVVSPLKSLMFDQVNHLKSNGINVSFGCVENDANAPEFFTSLMQHSPELIKKSTSVNNFQIVTEMIADSQMSDFGIVYCSSRFECESLARHLVNAGFTAAPYHAGMTDIICATNAFGMGVNKPNVKFIFHLTMPSSISSFYQECGRAGRDGFIASFVLLYQFSDHCYLQHLIDGKKIQETRDDERTQGNVELLREQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9GLL2</accession>
    <name>E9GLL2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_304485</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dpy-30 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732551">
        <property type="protein sequence ID" value="EFX79530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79530"/>
    <dbReference type="EnsemblMetazoa" id="EFX79530">
        <property type="protein sequence ID" value="EFX79530"/>
        <property type="gene ID" value="DAPPUDRAFT_304485"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304485"/>
    <dbReference type="eggNOG" id="KOG4109">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135823_4_0_1"/>
    <dbReference type="InParanoid" id="E9GLL2"/>
    <dbReference type="OMA" id="MPTSDKD"/>
    <dbReference type="OrthoDB" id="1596051at2759"/>
    <dbReference type="PhylomeDB" id="E9GLL2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051568">
        <property type="term" value="P:histone H3-K4 methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037856">
        <property type="entry name" value="Sdc1/DPY30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23356">
        <property type="entry name" value="PTHR23356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX79530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="85" mass="9171" checksum="2E476D2CF679B979" modified="2011-04-05" version="1">MPTSDKDNGEAGQSKKARVDHQTMPTRQYLDQAVVPVVLQAMSAVAKERPADPLEFIANYLLKEAKNRSTQTSETAAQAIPSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E9GMD1</accession>
    <name>E9GMD1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_304867</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732552">
        <property type="protein sequence ID" value="EFX79344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79344"/>
    <dbReference type="EnsemblMetazoa" id="EFX79344">
        <property type="protein sequence ID" value="EFX79344"/>
        <property type="gene ID" value="DAPPUDRAFT_304867"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304867"/>
    <dbReference type="eggNOG" id="KOG1384">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_2_1_1"/>
    <dbReference type="InParanoid" id="E9GMD1"/>
    <dbReference type="OMA" id="NGDAMQM"/>
    <dbReference type="OrthoDB" id="1003231at2759"/>
    <dbReference type="PhylomeDB" id="E9GMD1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="476"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX79344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="509" mass="57653" checksum="BAE9437F2DE96217" modified="2011-04-05" version="1">MAAVGLSRTTTRLLNSRLPVIVVCGATGTGKSKLALELAVKYGGEIISADSMQIYQGLDIITNKVTLEERQLVPHHLIDCASPLTRWTVVDFQRKSLAVIDDLLVNGRVPVIVGGTHYYIESLLWKVLLDGDHKSSRDQTTTLLYERDEQLRRQRPPARLHQLLRKVDPVMADTIHPNNRRKIFRSLQAWQQHGRPHSELLRSQRDSEGGSTLGGPLRYDADRTLIFWVQCQQEVLDRRLDARVDDMMSRGLVAELAHFHHLYNERRLQDEIKEADYTIGIFQSIGLKEFHEFLVLPSSEQTTQTGRRLLDQGVEALKSRTRRYARKQTKWIVKRFLEQPDRQVPPVYGLDATDVTEWNEKIRDVAFRIVDSFGSGQGPTGDGSECRPKPLAVAETSTREEQTSFHCPLCEKVTVGQRQWQEHLGSNRHRKLVKRAAANGDGLDQQSKPRRRQPRSANPAAKTDRADGKDETNAGGSQEAALTSAQAAQEEQQQQQPQLPPLQIDRQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9GMG4</accession>
    <name>E9GMG4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PBPe domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_319673</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732552">
        <property type="protein sequence ID" value="EFX79396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79396"/>
    <dbReference type="EnsemblMetazoa" id="EFX79396">
        <property type="protein sequence ID" value="EFX79396"/>
        <property type="gene ID" value="DAPPUDRAFT_319673"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_319673"/>
    <dbReference type="eggNOG" id="KOG1052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007257_0_5_1"/>
    <dbReference type="InParanoid" id="E9GMG4"/>
    <dbReference type="OrthoDB" id="884602at2759"/>
    <dbReference type="PhylomeDB" id="E9GMG4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="3">
        <location>
            <begin position="131"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX79396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="420" mass="47383" checksum="C6BF6892474C374E" modified="2011-04-05" version="1">MAIGNTTSDDDLRGSLQQGKELRVVTGHFELINVRHHHHVSVSALRFHLAEFIWSNYGIFKPHVSTVTLLVSEVEIHEADLGLVPVTVSLERYEAIEFSGFVRGDNTGILVKYPAANISFTSAFDVFSIGIWIGGISSGIAIAAVSVILSYVAKRLRMTERPVMSAGSFLWHLYGATISQGNHFPCRQPSQKLLVATWCFVTFVFVNTYNSTLTSYMSVTYQRPEINSFRDLATATPYKATVLIGSIQDIDLRRSQNGDLKMIADRVKKCSLDCRKFSFEELAVSVLEEENCVSIIPFSAGVALLRKYNAKSCRLAMAFESTSWKPMYLAVPKSSPYKEEINRASLWFYDTGLREHWFEVYEKPAPGQCRLDYNSKGVATKRSSNKIQLEHLQLPFLILFGGYLLAFIQFFREKCMCPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9GMN8</accession>
    <name>E9GMN8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_104576</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732553">
        <property type="protein sequence ID" value="EFX79129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79129"/>
    <dbReference type="EnsemblMetazoa" id="EFX79129">
        <property type="protein sequence ID" value="EFX79129"/>
        <property type="gene ID" value="DAPPUDRAFT_104576"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_104576"/>
    <dbReference type="eggNOG" id="KOG1509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_0_2_1"/>
    <dbReference type="InParanoid" id="E9GMN8"/>
    <dbReference type="OMA" id="PHTKENA"/>
    <dbReference type="OrthoDB" id="1322992at2759"/>
    <dbReference type="PhylomeDB" id="E9GMN8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX79129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="164" mass="18185" checksum="D51C256C7A3C9113" modified="2011-04-05" version="1">MLCAYKTLLSNRRVVLASASERRKEILGGLGFPFDVVQSPFDEDKNRPNTNDPKEFTQWTASQKALATIEDMKTQSNPPDFVIGADTVVFLEDNILGKPTDPDHAVEMLKILSGNVHSVVTGLSIHYKMEGGYKERLTSEVTQVKMATLNDLIIRSYVATGEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9GMP2</accession>
    <name>E9GMP2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_304937</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732553">
        <property type="protein sequence ID" value="EFX79258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79258"/>
    <dbReference type="EnsemblMetazoa" id="EFX79258">
        <property type="protein sequence ID" value="EFX79258"/>
        <property type="gene ID" value="DAPPUDRAFT_304937"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304937"/>
    <dbReference type="eggNOG" id="KOG0675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018224_2_0_1"/>
    <dbReference type="InParanoid" id="E9GMP2"/>
    <dbReference type="OMA" id="SGCGKWE"/>
    <dbReference type="OrthoDB" id="775337at2759"/>
    <dbReference type="PhylomeDB" id="E9GMP2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030433">
        <property type="term" value="P:ubiquitin-dependent ERAD pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="PTHR11073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="SSF63887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005128577" evidence="4">
        <location>
            <begin position="20"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="502"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="513"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX79258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="579" mass="65875" checksum="FBC5EC3188802C92" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPX3</accession>
    <name>E9GPX3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_320464</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732557">
        <property type="protein sequence ID" value="EFX78460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78460"/>
    <dbReference type="EnsemblMetazoa" id="EFX78460">
        <property type="protein sequence ID" value="EFX78460"/>
        <property type="gene ID" value="DAPPUDRAFT_320464"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_320464"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000987_0_0_1"/>
    <dbReference type="InParanoid" id="E9GPX3"/>
    <dbReference type="OMA" id="IEISCHT"/>
    <dbReference type="OrthoDB" id="1243641at2759"/>
    <dbReference type="PhylomeDB" id="E9GPX3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Roc" evidence="5">
        <location>
            <begin position="576"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="809"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1563" mass="175560" checksum="4E406405E4AC0344" modified="2011-04-05" version="1"> </sequence>
</entry>
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    <accession>E9GT71</accession>
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        <name type="scientific">Daphnia pulex</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX77324">
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        <property type="gene ID" value="DAPPUDRAFT_305857"/>
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    <dbReference type="eggNOG" id="ENOG502QSQW">
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="286" mass="32501" checksum="42C8D73F07F3EC1A" modified="2011-04-05" version="1">MPVLIGSEPISQLPETVEEIYKSFPFLEAEALKLVQSPLRVIDKPEGVLYITQKEYAVLHSSDENFSIVGTDDATTCHIVVLVNREESSVCVAHIDSTDDLEDELARMVFDVLGQQNMKNDFPLELSIMGGYCDEMRKSEVLTLDLLHFYNQLPVKFQLKSLCVGSVNTRSSNGINWPIMYGAAVNIHSDFVISPAKVYHSTEGVFKISPFNYRFQSQMAEWALKSDDFILNNFSTSPAVEPEHFSKEMKEVFQFIIHNPFPMISIFKFNKSLKYVPSPQGQWLKL</sequence>
</entry>
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    <name>E9GU33_DAPPU</name>
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        <recommendedName>
            <fullName evidence="6">Saposin A-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Ye Y."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX76967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76967">
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_321847"/>
    <dbReference type="HOGENOM" id="CLU_2888018_0_0_1"/>
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    <dbReference type="OrthoDB" id="865505at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0964">Secreted</keyword>
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        <location>
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        </location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="74" mass="7856" checksum="3B0461FB2CA34609" modified="2011-04-05" version="1">MRSLLIIFCVVLIAAFFVVETEQTPQLSVPGGRPPMVGGNRCTFGPAFWCASPQNAQLCGQGAVDHCNRVGFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9GW42</accession>
    <name>E9GW42_DAPPU</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="NTYMANE"/>
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    <dbReference type="PhylomeDB" id="E9GW42"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="SDR_fam"/>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="335" mass="36948" checksum="D039F6C1B82CE5CA" modified="2011-04-05" version="1">MFLFDLVPNSVVVGVILMLALKIYFDMSMGVCKSTKRLDGKTIIVTGANSGIGKETAIDLALRGGRIILACRDLEKAALAKDDIVEKSENNNIVIKKLDLASLDSVREFAADVLKNEPKLHILINNAGCALIGKKMTMDGLENQMQTNYFGHFLLTNLLIGLMIKTAELEEECTRVINVSSYANNFCKKLDLNDLNFVHDSTAGTLWAPFKIYGASKLCNILFSKELSNKLERHGKAVTVNSLHPGAVLTEFGRFSTVVTVFMRIFASFLKSPKEGAQTTIYLAVADDVANVTGQYFCDCKIAEPSKLAQDDGIAKKLWEISETIVKLEPTEKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GWE9</accession>
    <name>E9GWE9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_107229</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732570">
        <property type="protein sequence ID" value="EFX76198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76198">
        <property type="protein sequence ID" value="EFX76198"/>
        <property type="gene ID" value="DAPPUDRAFT_107229"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_107229"/>
    <dbReference type="HOGENOM" id="CLU_732081_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GWE9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX76198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="378" mass="42544" checksum="737ED84013B46589" modified="2011-04-05" version="1">MEKRMKEFRRGVAVKNETVQEIGNTRILKQWRANKKHFCQKRKTAFPNWPWQMVFFQKIYFYREPHGIHCQNPAHLGSVATLDVERDFCERCVKNGGSYTNYSFHWTLPELISIPSTCPIFFVVLVSRNSKRNSIANSMYADLNETILDNHRKIASILKLDTGLDYEIHVIAEIGQQGSVLSLLSDSHGHIFTDDNQLHLPAADISNLFISTPTAQPSDNNKRGVERNFTMLSGEQMLERGEEIQITQNSPESTEENIDGYITGMAIEGSSRVHRNVNYRKSKQLERHRVGEGKVIHINPVELTCSTVDPAELPVPSTAQFCCCDCFSPNAGTGGIKWKCCCCGCLGHESIAARLSFLRTGDLHGPAHSSDGSERVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GWN3</accession>
    <name>E9GWN3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_322662</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732570">
        <property type="protein sequence ID" value="EFX76149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76149">
        <property type="protein sequence ID" value="EFX76149"/>
        <property type="gene ID" value="DAPPUDRAFT_322662"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_322662"/>
    <dbReference type="HOGENOM" id="CLU_2186581_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX76149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="109" mass="12576" checksum="6D5045EECFC461AF" modified="2011-04-05" version="1">MKWLDVHYAERNRKFLRMELMVSQQMSLCNKLLGRSISRDELPNQLPDHVFTLHLDKLQDLNLSSKEVLFAGETAKDGQFLGHLETVGSQETLSDALERMAEELHDSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYG6</accession>
    <name>E9GYG6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_250392</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732575">
        <property type="protein sequence ID" value="EFX75385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75385">
        <property type="protein sequence ID" value="EFX75385"/>
        <property type="gene ID" value="DAPPUDRAFT_250392"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_250392"/>
    <dbReference type="HOGENOM" id="CLU_2075519_0_0_1"/>
    <dbReference type="OMA" id="IFISCPA"/>
    <dbReference type="OrthoDB" id="1485786at2759"/>
    <dbReference type="PhylomeDB" id="E9GYG6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F1_2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX75385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="118" mass="13123" checksum="58EDE1CD9CC959F1" modified="2011-04-05" version="1">MKGYPSVIVFPIRSRSVCTMSNCRRAVLVVWIVSLLLTAPVLFTKGTNPLTFTDGEESVTVNYCVETDGGVGLIFAIYQAVILLLAPGLVMIICYTYVIRELWLSTRNMRVLTNTNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZE4</accession>
    <name>E9GZE4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_108184</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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    </evidence>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Souvorov A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Manak J.R."/>
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                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
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                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="119" mass="13779" checksum="CA09E78271345054" modified="2011-04-05" version="1">MFRLEKMRDAVLLWPQQKKKGREADQQGMTSKLLYTLDRHAGTRCGGLIRPHAPRFDPFHSDFHATPLDYNTHDLTLKNRRETAGRPFFTRRGVFIISDHFDSSVDLTIRHTNTGRAGE</sequence>
</entry>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732601">
        <property type="protein sequence ID" value="EFX72273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72273">
        <property type="protein sequence ID" value="EFX72273"/>
        <property type="gene ID" value="DAPPUDRAFT_216184"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_216184"/>
    <dbReference type="eggNOG" id="ENOG502S4KI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075165_4_1_1"/>
    <dbReference type="InParanoid" id="E9H7N8"/>
    <dbReference type="OMA" id="YEATPAM"/>
    <dbReference type="OrthoDB" id="1583175at2759"/>
    <dbReference type="PhylomeDB" id="E9H7N8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5003241768" evidence="4">
        <location>
            <begin position="23"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX72273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="153" mass="17160" checksum="1CCF7E76BDB63211" modified="2011-04-05" version="1">MHQSKAQRISSFILLVATLIAAEEQPNYAPEASQPPYEATPAMPHSFAWSVKDEATNNDYSHQQESDDKVTSGSYRVVLPDGRTQIVTYRADDNGYVAQVKYEGEAKSKYPEYRTSSSSYDNNTPSYSGVETTTASIIPQQDYKDPEQNARYE</sequence>
</entry>
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    <accession>E9H8E8</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX71937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_227693"/>
    <dbReference type="HOGENOM" id="CLU_092176_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9H8E8"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5003241781" evidence="1">
        <location>
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            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="203" mass="21862" checksum="F693CF0792FCFC9A" modified="2011-04-05" version="1">MNFYIPSSLILCLAVMAIDFPKLAKSENLNDDSRFFIFNSTSGISFTTFTVLKGSTTITSTLTSTTSCTTSTAVLTTCTIGRRRRGLFYDDALAQGRHGRGLFYNDDEQGNKDGTVFLPAQIKSSDDPEDESQLNLAADKTSVIPLVIEAGFELPEGSPVNRFLLAFGTNTITSYTISTSTITLTAICSSTTGFPLCGNVGRK</sequence>
</entry>
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    <name>E9H8M5_DAPPU</name>
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            <fullName evidence="1">PAPA-1 domain-containing protein</fullName>
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    <gene>
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    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Sakarya O."/>
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                <person name="Shiga Y."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX71919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71919"/>
    <dbReference type="EnsemblMetazoa" id="EFX71919">
        <property type="protein sequence ID" value="EFX71919"/>
        <property type="gene ID" value="DAPPUDRAFT_5569"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_5569"/>
    <dbReference type="eggNOG" id="ENOG502QUQX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070409_2_1_1"/>
    <dbReference type="InParanoid" id="E9H8M5"/>
    <dbReference type="OMA" id="YERTQDS"/>
    <dbReference type="OrthoDB" id="1111317at2759"/>
    <dbReference type="PhylomeDB" id="E9H8M5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
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        <property type="entry name" value="INO80B_C"/>
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        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="PTHR21561"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="79"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="210" mass="23473" checksum="68F5D62B1A031709" modified="2011-04-05" version="1" fragment="single">RTRDDGEGSSGEEAWLKALESGKLEEVDDELKKIKNPKLMTVRQRALLERKGELQNEEIIKEELVALPTGYKETVMTEELLKKKAIKSERRREVAAQKREKEKKRTIDRLLLKKESKLNKSCAASISASTSSASVSVPSHVSSYTWKQTQDGEITFSVPIGAAFPLAPQSVKEPPARVNCGVQGCTNFKRYSCSKTAVPLCSIQCYRKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9L0</accession>
    <name>E9H9L0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_111697</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732609">
        <property type="protein sequence ID" value="EFX71495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71495">
        <property type="protein sequence ID" value="EFX71495"/>
        <property type="gene ID" value="DAPPUDRAFT_111697"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2160929_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX71495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="111" mass="12733" checksum="67036FDCD1AE69C0" modified="2011-04-05" version="1">MANPKDFTATENTEDPEIPEVSEEDESDVEKESEDPEVEDDQQESHCSTYGCRYFLLTAAIIYFGIIGIAWFFMYLGRFSILRGFQHVKNTFNSTFSNNFENLITAVRDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9R4</accession>
    <name>E9H9R4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_255621</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732609">
        <property type="protein sequence ID" value="EFX71447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX71447"/>
        <property type="gene ID" value="DAPPUDRAFT_255621"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_115560_1_0_1"/>
    <dbReference type="InParanoid" id="E9H9R4"/>
    <dbReference type="OMA" id="TKSAEYY"/>
    <dbReference type="PhylomeDB" id="E9H9R4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX71447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="104" mass="12396" checksum="574818370B0463C8" modified="2011-04-05" version="1">MFNYLPPYYTTKSAEYYTTKSAEYYTTKSAEYYTTKSAEYYTTKSAEYYTTKSAEYYTTKSAEYYTTKSAEYYTTKSAEYYTTKSAEYYTTKSADNSYYVEPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9HA32</accession>
    <name>E9HA32_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_201727</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="GL732610">
        <property type="protein sequence ID" value="EFX71358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71358"/>
    <dbReference type="EnsemblMetazoa" id="EFX71358">
        <property type="protein sequence ID" value="EFX71358"/>
        <property type="gene ID" value="DAPPUDRAFT_201727"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_201727"/>
    <dbReference type="eggNOG" id="KOG1720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017787_0_2_1"/>
    <dbReference type="InParanoid" id="E9HA32"/>
    <dbReference type="OMA" id="TTLCKSY"/>
    <dbReference type="OrthoDB" id="1357618at2759"/>
    <dbReference type="PhylomeDB" id="E9HA32"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902636">
        <property type="term" value="C:kinociliary basal body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032467">
        <property type="term" value="P:positive regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026070">
        <property type="entry name" value="CDC14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339:SF27">
        <property type="entry name" value="PTHR23339:SF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="121"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="8">
        <location>
            <begin position="207"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX71358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="335" mass="38441" checksum="427515306FDDCE0F" modified="2011-04-05" version="1">MLYRYCHKLNRKLKAPNLAKKCIVHYTTEDQHKRANAAMLIGSYAVIYLNKSPEEAFRLLTSGNSPTFLPFRDASYGWAEYSISILDCLHAIEKAIKFNFFDFSDFDVDEYEHYERVENGDFNWIIPGKFIAFCGPHSTKNEEEGALLLTRQHTPESYFNYFREYDVTTIVRLNKRIYDAARFTRGGFQHRDLFFTDGSTPSDLIMERFLNISEATSGAVAVHCKAGLGRTGTLIACYMMKHYRMTAHESIAWLRICRPGCVIGHQQTWVERLVGKYYMQNSNIIESVTVLSNEFFCPFFFCPANNCKCGCRRTSTTMRTTASLWGSSALSPSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9HA51</accession>
    <name>E9HA51_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_201747</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732610">
        <property type="protein sequence ID" value="EFX71369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71369"/>
    <dbReference type="EnsemblMetazoa" id="EFX71369">
        <property type="protein sequence ID" value="EFX71369"/>
        <property type="gene ID" value="DAPPUDRAFT_201747"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_201747"/>
    <dbReference type="eggNOG" id="KOG2809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047130_2_0_1"/>
    <dbReference type="InParanoid" id="E9HA51"/>
    <dbReference type="OMA" id="ILGKYGW"/>
    <dbReference type="OrthoDB" id="1573336at2759"/>
    <dbReference type="PhylomeDB" id="E9HA51"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090069">
        <property type="term" value="P:regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX71369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="335" mass="37718" checksum="A94E06FFA347150C" modified="2011-04-05" version="1">MDSQGMKNAKKILEKLGWAEGSGLGLNKDGITEAIKPSKKFDLSGIGHKNFNDFQWWDHAFNKAAQAFDIKVTDDQGVIVEKTEAIGKIKTKKGSSNLDQNNLAYGVFHKTGTLHNGIVESTESTFKLKEETDYSLKLSDEELFKLCNGLTAHKGARHGLTASGKLARIAKQEAAMLASMNKKKSVEINSNEKIEQTTCIANEIVSVPHSDDMITSNERSTKSKKKKKSRKEIDCATDEMNSHADIQDAPETSFLISKKEEKRKKKKEAKNRENQTELLVPEPVEEPIEEPRKKRKKVKTIDNEAEQPLLEESIQQTCDEPKKKKKKKNRDKFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HA80</accession>
    <name>E9HA80_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_111826</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732610">
        <property type="protein sequence ID" value="EFX71394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71394">
        <property type="protein sequence ID" value="EFX71394"/>
        <property type="gene ID" value="DAPPUDRAFT_111826"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_111826"/>
    <dbReference type="HOGENOM" id="CLU_1205847_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="230" mass="25802" checksum="455F2B61D86E1551" modified="2011-04-05" version="1">MVSLMSQSSTSSFIATYLASLDSAFTQLVVNLRYPRLPHSTSSLRTGSFGQQWCDTSLLLRDSGGLSSTTFILYFCFMDFTLILWPYVWYAVSAGAGRSKCRVQFSTDVDHQTVLGNDDKGTTDDDDIRSPWFSLLLRRPPVDVRLRRVWPVVCVGSLLTGVGHCRRTGRQQQCEARIDPPVIFRLHHVMTDETLPNFGCREASDPIALWTFPTPLSSDLVGFDLAFYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9HAM8</accession>
    <name>E9HAM8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_111979</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
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                <person name="Wolf Y.I."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="158" mass="17706" checksum="13CD42929EDCE437" modified="2011-04-05" version="1">MTYNLKAMSKKSVRTEDVPNVPETRTEFISEPEKEESNTVRDAPEEDHQPEREATEADHKEDDLQEESFVPSIDSNEEDEVSEFSHSMEGSDEEQEPGVKKETLDDSSSSSEATGSSLKYSSAGQTTMSTSTCKQQFTMPSLSSFSSEEEEEKEKTNQ</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Pritham E.J."/>
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                <person name="Schaack S."/>
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                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Tang H."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_256613"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3089381_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HBS0"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="52" mass="6240" checksum="2317295A5A573D0F" modified="2011-04-05" version="1">MVVPRDISEQRLDYVHWDMDGNQMFRYPMDIQEMGCATWDDEHRVVDLGLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
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    <gene>
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    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CH-H</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX70632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="SVE83921.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70632"/>
    <dbReference type="EnsemblMetazoa" id="EFX70632">
        <property type="protein sequence ID" value="EFX70632"/>
        <property type="gene ID" value="DAPPUDRAFT_309391"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309391"/>
    <dbReference type="eggNOG" id="KOG0071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="OMA" id="WSVIPTI"/>
    <dbReference type="OrthoDB" id="1362554at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="PTHR11711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX70632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SVE83921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="175" mass="20099" checksum="89E744B65CBD300A" modified="2011-04-05" version="1">MGKILSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIFANKQDLQDAMKPHEIQEKLGLTRIRDRNWYVQPACATTGDGLYEGLTWLTSNHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCE3</accession>
    <name>E9HCE3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="3 6">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LDH-B</name>
        <name evidence="9" type="ORF">DAPPUDRAFT_61140</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="3 6"/>
    <dbReference type="EMBL" id="GL732619">
        <property type="protein sequence ID" value="EFX70625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70625"/>
    <dbReference type="EnsemblMetazoa" id="EFX70625">
        <property type="protein sequence ID" value="EFX70625"/>
        <property type="gene ID" value="DAPPUDRAFT_61140"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_61140"/>
    <dbReference type="eggNOG" id="KOG1495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045401_0_2_1"/>
    <dbReference type="InParanoid" id="E9HCE3"/>
    <dbReference type="OMA" id="AFTRHCT"/>
    <dbReference type="OrthoDB" id="1204514at2759"/>
    <dbReference type="PhylomeDB" id="E9HCE3"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="7">
        <location>
            <begin position="13"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="8">
        <location>
            <begin position="155"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX70625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="324" mass="35294" checksum="3CA4406B8E499640" modified="2011-04-05" version="1">MQTKASVDTVSGTKVTVVGVGQVGISIAFSIMTQGIASEMTLVDVMEDKLKGELMDLQHGLTFLDNMKITAGSDYALSAGSKLCIVTAGAQMREGESRLDLDQRNTDILKDIIPKLVQYSPDTILLIVSDPVDLLTYVAWKLSGLPKERVIGSGTNVDSSRFRFLLSERFDVAPTSIHGWIIGEHGDSSVPVWSGVDVAGVRLRDLNPAAGTSEDTENWNSIHRQVIQSAYEIIRLKGYPSWAMALSVSVLTRAILNNTRNVYAVSTFVEGIHGVQYPVFLSVPCVLGENGITDVIQQTLTEDERTQFQKSAATLNEVQSNLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCH2</accession>
    <name>E9HCH2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_112641</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732620">
        <property type="protein sequence ID" value="EFX70535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70535">
        <property type="protein sequence ID" value="EFX70535"/>
        <property type="gene ID" value="DAPPUDRAFT_112641"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_112641"/>
    <dbReference type="HOGENOM" id="CLU_004416_4_0_1"/>
    <dbReference type="OrthoDB" id="775399at2759"/>
    <dbReference type="PhylomeDB" id="E9HCH2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="588" mass="67247" checksum="82836F1F4C4B7D53" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCP8</accession>
    <name>E9HCP8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_112628</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
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                <person name="Tsuchiya D."/>
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                <person name="Yamagata H."/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="235" mass="27476" checksum="CBA381BBC544FA12" modified="2011-04-05" version="1">MAEHAGNEIGSMRAVAHVPKFDGTNHREWNYQLHLSFQGMEIDQVVTGTEVLHEEEFDDEGEITNEAEIKQWTRKDVLARNCIMATTSKEMKENLYTCTSSAQMWTRLHQQYHLQTEEHLHVLWQNYYDYSYTDDPDVAKQYAQQCLNLGLDFSDAIKTLQESNVLENPLEKDCINRMLKENNETIAELSKDWIFFNGPVKDFISLESTPPARSIYYICRRHVDDLQTSSRMRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX70001.1"/>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="312" mass="35404" checksum="5ABC7F86902805E6" modified="2011-04-05" version="1">MEKETVKDKRCVLHIDNLPSSANIILFQDFTLKKCQDAELVHKYRLNKGTSFYKDIVLPSVPDSHSGYHSKCYSKYTAVSSASKQRVVQQKESDDTPSPEASAEPLPEVNHNIGRRSLRSKPTDTETDKSSHIFPTVCLFCEKKDKKISGKREVLNQILTIEFQEIILGVDLVAKEGRYHNSCRKAYSYQAAVISRRLSEQSEKATSDSQRKSAIRKNAFDSTTSYIEAHIFVNEEVHRFNTIAEHYTMVLAEFGFDYEDLAYVRKDFFLAKLPCKTAPSSLEDIVVSENEEDEEVEDGSSDDDSADDSEDD</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PhylomeDB" id="E9HEW1"/>
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    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX69744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="74" mass="8340" checksum="E5C760C8BEAABC07" modified="2011-04-05" version="1">MEDSDSREEDVGSDSREEDVGNEPGVQEKPIKADHGNVRKSPKGVGNGLSDPTRRRVTLQFKREAQRISEKYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
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    <organism evidence="3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX69680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="287" mass="32166" checksum="70540C3E48CE295B" modified="2011-04-05" version="1">MDSANKLEENTASEPEEGGSPPKKTKTDCLMHEIENRNAVGVESLIRQGVDVRITGNFSLSEQQKYVNVPPLFAAIILDLPKIVDTLVMEYHHFYLEETADDSQQDSFSLPNDSDKEKNSNNLQQDSVNPPTNSDQEKKTNDSLQESVNIPTYTEKEQKEHANCSLQDSVNLPTNSEKKQQIDVMDLVGAACVFRGSHGVQNHGLSCWEVAIDMRADNDIPKIILPQSKLEDIVFRRSEVVSSACLIKLRSQNPMDWMCEAFIKSHRILKESGRFPSPPFKTGKFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9HF62</accession>
    <name>E9HF62_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NifU_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_300869</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732633">
        <property type="protein sequence ID" value="EFX69636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69636"/>
    <dbReference type="EnsemblMetazoa" id="EFX69636">
        <property type="protein sequence ID" value="EFX69636"/>
        <property type="gene ID" value="DAPPUDRAFT_300869"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300869"/>
    <dbReference type="eggNOG" id="KOG3361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_1_2_1"/>
    <dbReference type="InParanoid" id="E9HF62"/>
    <dbReference type="OMA" id="YKNPRNY"/>
    <dbReference type="OrthoDB" id="1406557at2759"/>
    <dbReference type="PhylomeDB" id="E9HF62"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISC_FeS_clus_asmbl_IscU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NifU_N" evidence="3">
        <location>
            <begin position="27"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX69636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="164" mass="17807" checksum="DD23F622723AED35" modified="2011-04-05" version="1">MAMYQNISRALLRSRSASQPTISCASYHQKVIDHYEKPRNVGSMDKKDINVGTGLVGAPACGDVMKLQIKVDENGKIIDAKFKTFGCGSAIASSSLATEWVKGKSVNDALKIKNTDIAKELSLPPVKLHCSMLAEDAIKAALKDYQVKQTSHKKAEEKRSAVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9HFN0</accession>
    <name>E9HFN0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_113645</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732636">
        <property type="protein sequence ID" value="EFX69474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69474">
        <property type="protein sequence ID" value="EFX69474"/>
        <property type="gene ID" value="DAPPUDRAFT_113645"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_113645"/>
    <dbReference type="HOGENOM" id="CLU_681992_0_0_1"/>
    <dbReference type="InParanoid" id="E9HFN0"/>
    <dbReference type="OrthoDB" id="1930400at2759"/>
    <dbReference type="PhylomeDB" id="E9HFN0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX69474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="404" mass="44727" checksum="96ABB4F052EC7799" modified="2011-04-05" version="1">MGDGEQKNWPAVSPHHSGETLQDAGRVQREQLSRILDVTDHAKSIDFASGADVFPVDSAHNFQQWQADVQGFPVPVSKQNIGKLQDVFGPGLDSEGNVKFSGSLTGELHIGDFDLSSAVVRHLRLPDAMQVVAKCAKLVLYNDKNCLKSNLSSRGHQGGSLNVTYHKKLKRIETYISSDTGYYLSAFFNSSEHFIEPVSRGHKLLAVYDILWVNAKTFWQKPRDSTVTERDLVDNVFLFVLLHTYGEWTLGFELLQGADRDLANLFRNCDFLDVHLAMASPPSWTPSSDNAKTVQVSSAIDSSDVSRNLSLQLHGKRNVIGLIENQPENAIGKDRSKRDFVEIGLGFSPRGVLMIVGYCALCAIPFLSSVHYVLSGNAVYQTSAFICYSPLFLVLTSVLLIYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGE3</accession>
    <name>E9HGE3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_258992</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732640">
        <property type="protein sequence ID" value="EFX69218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69218">
        <property type="protein sequence ID" value="EFX69218"/>
        <property type="gene ID" value="DAPPUDRAFT_258992"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_258992"/>
    <dbReference type="HOGENOM" id="CLU_1361652_0_0_1"/>
    <dbReference type="OrthoDB" id="467693at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX69218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="201" mass="21879" checksum="5AF0FC5F5DCF0813" modified="2011-04-05" version="1">MDQIGRYGGPSNSRGGNTHFRKGKSNSGSGANFKSNGNWNFIQPHSSNRNKSGEQQLPALLIITIPVTSQHRNFLRFIWDGVVYQYGWGSVCDGVTARGQGPLADQSRHINELEPGVTVDIGPKRLDAIHRGIQTSPGCVAHGGGSFFGGVEQTIAEVCFLATPAERDSRERLLPQLVTPELLRVPPIRNDSDMSDKDKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGJ1</accession>
    <name>E9HGJ1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_329418</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732642">
        <property type="protein sequence ID" value="EFX69140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69140">
        <property type="protein sequence ID" value="EFX69140"/>
        <property type="gene ID" value="DAPPUDRAFT_329418"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_329418"/>
    <dbReference type="HOGENOM" id="CLU_062761_0_0_1"/>
    <dbReference type="InParanoid" id="E9HGJ1"/>
    <dbReference type="OrthoDB" id="1046098at2759"/>
    <dbReference type="PhylomeDB" id="E9HGJ1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241780" evidence="1">
        <location>
            <begin position="17"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX69140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="309" mass="35517" checksum="1C4A36BB58249395" modified="2011-04-05" version="1">MPTVKSVKSLFQLCVAFIVSIIEDSDFPVKPSTINEVPMELEEVVNPFHQLPISVLEQIIVNVNFAYHTYGKPTNTFVLEYLISPQLRFFRFHYYTEEYLTVFPQFGKLLSLNLRYTKAGDNCLHLIGNYCKNLRMLDIHHCQRITDIGVRSLCFNYDDLEKPAGLCKTLQYLLMYCTSVTKQGAQLAINNLTKLKSLHHESTFEVLVEFLQKRLDQNLSEIPNMFSLVNLRIGYVTPYRKGSLGQVVQLISSSLTSVIIIAMKELTDTDLLSLTSLKNLRQFHLNRPKELKEYKGFEITTVKKGLVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9HHA8</accession>
    <name>E9HHA8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_218141</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732647">
        <property type="protein sequence ID" value="EFX68833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68833"/>
    <dbReference type="EnsemblMetazoa" id="EFX68833">
        <property type="protein sequence ID" value="EFX68833"/>
        <property type="gene ID" value="DAPPUDRAFT_218141"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_218141"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="E9HHA8"/>
    <dbReference type="OMA" id="HLAKMVP"/>
    <dbReference type="OrthoDB" id="683933at2759"/>
    <dbReference type="PhylomeDB" id="E9HHA8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="6"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="396"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX68833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="487" mass="53028" checksum="662A6669F53045FF" modified="2011-04-05" version="1">MLGHLIRKCGSALTRAGYKKGDVMAIISPNVPEFPVALLGAASVGMPVALVNPTFTPEEIARQLTSVGASVIFGVAPMAEMLQKMAQMCPSVHQVILLGPPQEGFVCFQQMLQDSGDLFNDNVDVKDTFILPHSSGTTGLPKSVMLTHANVGVNVSQNIHPRTSKNQMATDQYQEIHICLLPFFHSYGITGMLNIGFDLGAKLVTLPRLDVPSYLKAIEDHKPTLLHIVPTLAQLFIKHPALKMENFERVHTLFSSAAPLGAQTANNLLGKFNKPDLLVQEGYGLTEMSPGAMQTPLNNDHLGSCGRLISRTKAKIVDLESGKTLGPNQQGELYMTGPQVMKGYWNNPQATKEMIGEDGWLRSGDVAYYDEGGNFYIVDRLKELIKVKGLQVAPAELEDILSGHPAVVEAAVIGIPDEHAGELPRAYVVRKPGMESVSDAEIRTYVDSKVSSHKQIKGGIEFCDALPKNNLGKVLRRELRSQYAQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E9HIR4</accession>
    <name>E9HIR4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DAPPUDRAFT_11119</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Postsynaptic cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL732657">
        <property type="protein sequence ID" value="EFX68323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68323"/>
    <dbReference type="EnsemblMetazoa" id="EFX68323">
        <property type="protein sequence ID" value="EFX68323"/>
        <property type="gene ID" value="DAPPUDRAFT_11119"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_11119"/>
    <dbReference type="eggNOG" id="KOG3645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018074_1_3_1"/>
    <dbReference type="InParanoid" id="E9HIR4"/>
    <dbReference type="OMA" id="MHEFLQD"/>
    <dbReference type="OrthoDB" id="381858at2759"/>
    <dbReference type="PhylomeDB" id="E9HIR4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated cation-selective channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005231">
        <property type="term" value="F:excitatory extracellular ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
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        <location>
            <begin position="220"/>
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        </location>
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        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
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        <location>
            <begin position="6"/>
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        </location>
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            <end position="475"/>
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        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
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        </location>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="492" mass="56448" checksum="6D22B4D9B06665F7" modified="2011-04-05" version="1" fragment="single">ANPDAKRLYDDLLSHYNRLIRPVSNNSQVVTVGLGLHLTQLIDLDLKNQILTTNVWVEHEWKDSKLTWDPEEYGGVRELMVPSKHIWLPDLVLYNNADGEYAVTTMTKAILHSDGHVKWNPPAIFKSYCEIDVRYFPFDTQTCFMKFGSWSYSGLQMNLRHLHSPDEDLVEIGMNLKDYYPSGEWDILNVPAERHAKKYDCCPEFFVDIYFNITLRRKTLFYTVNLIIPCVGISCLSVLTFYLPADSGEKVALCITTLLSQTMFFLLMSEIIPSTSLAMPLLGKYLLFTMCLVGLSVLITIVILNVRYRKPSTHKISPWVRRFFIQQLPKMLLMRIPKDSSTSLPNTPSLRSCCDGGAAAAMATDASMMGRGRDCAMMMTCSPNDDDDDDGSLLMRRRRRHSSGLHQQQRRRRVPKRFPLELQKAIRDVQFIQNHMKRADEYDEEDNDWGFIAMVLDRFFLWVFTAASLCGTISILFTAPALYDDSSPINLK</sequence>
</entry>
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    <accession>E9HIR7</accession>
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        </lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Rho M."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="54" mass="6077" checksum="FD6FA6F59D884E34" modified="2011-04-05" version="1">MSSLAACDGCTFHHMEKYYNYRTVYVPIVAVASTLETNVHCGILLQPLLMVKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJ33</accession>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
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                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX68249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1225885_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HJ33"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="226" mass="27290" checksum="8B3573202BA5E97C" modified="2011-04-05" version="1">MENFETGNEMDNVRDQRYHSRRKRKEFASFMHEVFRRFPLSSTRDVILTKEERNRSFILEHIPEAVLASRVYFFVNIFGTLRDFSMSKPNRRRKHRGTSTVIVEFESGEDRERFLRECGARQVYMFQARRITDAVDVFPRHHKGNVQMEKMRKRRYEEREKRLVFTHFMEMVKKTFPYSTTKDVLMTWEEMNKSFLLTKIPETTQGFLHCEAEASQKEKGDHGNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKA8</accession>
    <name>E9HKA8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DAPPUDRAFT_203579</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732667">
        <property type="protein sequence ID" value="EFX67867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67867"/>
    <dbReference type="EnsemblMetazoa" id="EFX67867">
        <property type="protein sequence ID" value="EFX67867"/>
        <property type="gene ID" value="DAPPUDRAFT_203579"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_203579"/>
    <dbReference type="eggNOG" id="KOG3575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001479_1_0_1"/>
    <dbReference type="InParanoid" id="E9HKA8"/>
    <dbReference type="OrthoDB" id="619653at2759"/>
    <dbReference type="PhylomeDB" id="E9HKA8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="SSF48508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="323"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="476"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="161"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFX67867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="728" mass="79996" checksum="D27A8DE27C3B3BE4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKV3</accession>
    <name>E9HKV3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_115285</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732673">
        <property type="protein sequence ID" value="EFX67590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67590">
        <property type="protein sequence ID" value="EFX67590"/>
        <property type="gene ID" value="DAPPUDRAFT_115285"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_115285"/>
    <dbReference type="HOGENOM" id="CLU_785854_0_0_1"/>
    <dbReference type="InParanoid" id="E9HKV3"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="PhylomeDB" id="E9HKV3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="SSF57756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX67590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="353" mass="39486" checksum="5D9218FDF18FA906" modified="2011-04-05" version="1">MALEKNQKLISDLLQKKEEKKQKKRDEGFINAVSTNSNVQAMDDTKRDLEELKITAKNNQKLLSDMMQQARETTKLMNQVSQLQAQAVVPNQSVFPPQNQRNQQSHHHSNQFAERNIQGPQPPARYGGQPNNQTNRYPPREAKYCAYCAKTNASNPVTHNTEMCGFGPHGPTCFKCKQTGHLARDCPETQNSPNGMIKNEIKYYNADTPVDLYGVENTRLTTRGLITLEISVLGDNLLQDFIVVDGISEECILGLDALYEHKFIIDGSERKIYRVKKTTLPDSAPTIMAGKKITIKPFSATVVESEGNGAQLPPNLAFYLNRGPGLNSGLRLDPFISKGDEGAFFFNSHSKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKV7</accession>
    <name>E9HKV7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_330864</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732673">
        <property type="protein sequence ID" value="EFX67594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67594">
        <property type="protein sequence ID" value="EFX67594"/>
        <property type="gene ID" value="DAPPUDRAFT_330864"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330864"/>
    <dbReference type="eggNOG" id="KOG2349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_11_1_1"/>
    <dbReference type="InParanoid" id="E9HKV7"/>
    <dbReference type="OMA" id="ERYTFWS"/>
    <dbReference type="OrthoDB" id="1180002at2759"/>
    <dbReference type="PhylomeDB" id="E9HKV7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX67594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="636" mass="69353" checksum="9E688556571E4CCC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLS7</accession>
    <name>E9HLS7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_115556</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX67285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67285">
        <property type="protein sequence ID" value="EFX67285"/>
        <property type="gene ID" value="DAPPUDRAFT_115556"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_115556"/>
    <dbReference type="HOGENOM" id="CLU_817001_0_0_1"/>
    <dbReference type="OrthoDB" id="1358897at2759"/>
    <dbReference type="PhylomeDB" id="E9HLS7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="340" mass="38797" checksum="C5DEA391A85FF65C" modified="2011-04-05" version="1">MKVVRKTPEFSKKVKISCIYKFLVVGNPQKLVPFLTVTFTLLDFLIHRCRKADAHIRLTSLGSADNIVYPRHIKNQERYGSLSEETYLCDTLPSLDEIKNTMEKAGVDAKMELEALMGVCLGDSDDKIFNFDARLAFKLSESLEAPTPTDDDAFEFDECEEVACEGEDTFNFIDSYEKSLLKSIEGAQLTDYSSLLESRLIKYCEKEKEKPVRDTDQEILSSPFIVITREDGAVVTFKKQTIVWLCENGVKKQSNDRLKRVTQSSNFLLAQKLIINFPEKRKIRIGDWCMFKSDVTGRGKKKKQRVLVGRALSFMLMSGGKNEMKQIIYNWDGEKNVGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLU0</accession>
    <name>E9HLU0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_203728</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732681">
        <property type="protein sequence ID" value="EFX67298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67298">
        <property type="protein sequence ID" value="EFX67298"/>
        <property type="gene ID" value="DAPPUDRAFT_203728"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_203728"/>
    <dbReference type="eggNOG" id="KOG3660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006855_9_5_1"/>
    <dbReference type="InParanoid" id="E9HLU0"/>
    <dbReference type="OMA" id="CVINTAT"/>
    <dbReference type="OrthoDB" id="250396at2759"/>
    <dbReference type="PhylomeDB" id="E9HLU0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
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</entry>
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                <person name="Arnold G.J."/>
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                <person name="Carmel L."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP</text>
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            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
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            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
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        <location>
            <begin position="230"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="385"/>
        </location>
    </feature>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX67071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="385" mass="43949" checksum="63352A594FE08C28" modified="2011-04-05" version="1" fragment="single">SKERYDLIILDGFSNDCTLLLAEVFDVPFIYLNCFPPTPWLLYAIGSPLAMDHFPNPSGTRDKMDLWQRTFNVVTQVVTGLGGLFIYNWHILPTIDRVASRVLGKHNLTPILDIQSRRLSLLMTNTHFSINFQLPTSPAVVEVGGLHLGGKLKRLPKDLVSFLDGSGDAGFIIVSFGSMLRGDGLPKDFRRLFLSVFARLPQRVVWKWENQSKLGESEELIPSNVKTISWLPQKELLSHRNARLFISHGGLLSKQETIFNGVPAIFLPVWADQPINAQKAEDDGYAIRLCWDELTEEILYNAIQAILTNPRYAKRMQQVSALMQDQIDKPMGRAIYWIEYVIRHQGAPHLRNASRDLMLPQRALLDVMCIFFIFTFSMIYVIYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
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            <taxon>Daphnia</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_262486"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="95" mass="10558" checksum="08F33B57AFDC4C46" modified="2011-04-05" version="1">MRLLFAGYGCPTVAGFGYYSLPERSTVVNPQVPPVVPPIVIRVRPELPRFVPAPFGRRPEAKLVSKCLRQITVDSQSKTFSHLVIAILFKTHPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPK3</accession>
    <name>E9HPK3_DAPPU</name>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Daphnia</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX66280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX66280"/>
        <property type="gene ID" value="DAPPUDRAFT_229443"/>
    </dbReference>
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    <dbReference type="PhylomeDB" id="E9HPK3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012903824" evidence="2">
        <location>
            <begin position="16"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX66280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="172" mass="19281" checksum="8FCB4114B6A5F64C" modified="2011-04-05" version="1">MKLFVLAAILAVAAAAPSGYKTEEEKYGKDYKYPEITVTGQSDERNLDGSSKWNYAQSDYTTREEAQEQKKFTVTKVDDYGKETKEEVFGNTNKGSSYWVSPEGEKFTLTWVADDAGFQPKGDHLPVAPVHVYELPVAPVHEYVLPVAPVHEYELPVAPVHIPFNGKGYKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HQZ0</accession>
    <name>E9HQZ0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732728">
        <property type="protein sequence ID" value="EFX65843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65843">
        <property type="protein sequence ID" value="EFX65843"/>
        <property type="gene ID" value="DAPPUDRAFT_264144"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_264144"/>
    <dbReference type="HOGENOM" id="CLU_2560591_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX65843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="82" mass="9460" checksum="A575B7D709E1C657" modified="2011-04-05" version="1">MYGISDPTISAPYHFGPISTIWKKIANEKRNIELSLIKQAITTHYTPLGGFAKISEVHYLKKFNSKTMVGYYRMKFKVSIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HT34</accession>
    <name>E9HT34_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_333527</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
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    <dbReference type="OrthoDB" id="999269at2759"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="427" mass="48337" checksum="F80DB8C89C4969B6" modified="2011-04-05" version="1">MPPKSKECFSSPKDKKRSKKRQQLKATNCEQNNIMDNNLRIAQQNSSALQIQEGSSETTDIVDQPIDDSPTPDGFVDVEIPDMLEVEVLHYADSSVPSLKFNQNASRPILLNSFTLYSKGTPFFQQLKHFERDPSIALLTMAVNSGQSQFAKVDGKYYHLHPELVKNNFATLWIDFGNPERIGLPTSTLIEELLLAQSRLYVSIVKLIGNKLSERQSAKRGHVITFPQPDGPTKLTELQRMNSEEMEDYPRIENLSEFISVVFVGTRLQFEALVPSRFPDVRELRVRVEVVYQWLLALKHLNPLYRNVDVVETNAMHDALNLISSDLMKNFTLVDNETDKRIDRLLTPEGTTYVPAEEVNHICDSSLDQTLPSSFLTRSIPLTVDKSDSVRTAICGLLSTFEGQANLTDATELTEQTLYRGKTFMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9HTA8</accession>
    <name>E9HTA8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative positive regulatory Domain/B-lymphocyte induced maturation protein 1, version B</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="primary">PRDM1B</name>
        <name evidence="6" type="ORF">DAPPUDRAFT_333601</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX65028"/>
    <dbReference type="EnsemblMetazoa" id="EFX65028">
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        <property type="gene ID" value="DAPPUDRAFT_333601"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_333601"/>
    <dbReference type="eggNOG" id="KOG2461">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9HTA8"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
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    </dbReference>
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        <property type="entry name" value="SET_dom"/>
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        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
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            <begin position="227"/>
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        </location>
    </feature>
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        <location>
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    </feature>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
    <sequence length="318" mass="36521" checksum="DE30D99446AAE064" modified="2011-04-05" version="1">MYTQQEVRRGVYNNSEVFYYIDGYDTGKANWMRYVNPAYSFESQNLIVCQYKMNIYFYTTKPILPNHELLVWYCKEFAERLNYPVTGDLMLQRIRQQVQQNDEDGTDTESTAEIKKPNETEPSSPAAPGSGSRAEENKVKHKKLQNPSNYSQALHCHTSPGSGSLSPIRSGSPYPNGSQGRGYRSLPYPLKKKDGKMHYECNICYKTSGQPSILKVHLRTHSGERPFKCNVCTKSFNQLAHLQKHHLVHTGEKPHQSDISKKRFSSTSNLKTHLRLHSGQKPYACDLCLAKFTQFVHLKLHKRLHIKERPYTCGGCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9HU30</accession>
    <name>E9HU30_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the otopetrin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX64757">
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        <property type="gene ID" value="DAPPUDRAFT_333874"/>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Wolf Y.I."/>
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            <dbReference type="PubMed" id="21292972"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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        </location>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX63901.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="685" mass="78106" checksum="9429A12040B64159" modified="2011-04-05" version="1"> </sequence>
</entry>
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            <taxon>Daphnia</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
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                <person name="Robertson H.M."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX63896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="67" mass="7808" checksum="ED7B108B3D206383" modified="2011-04-05" version="1">MFGEEIDDPARARLRERRDCSSELNCTNVYQKLWNETERDFASGRKTAMTGAGPTTHSTWIIYFCSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9HXC4</accession>
    <name>E9HXC4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733027">
        <property type="protein sequence ID" value="EFX63607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63607">
        <property type="protein sequence ID" value="EFX63607"/>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_119071"/>
    <dbReference type="HOGENOM" id="CLU_788142_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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        <location>
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            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="352"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="319"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="352" mass="40597" checksum="9639CCB0EB2E48A0" modified="2011-04-05" version="1">MDKKDLLIQKDGEIIELLPNNPTVKARLLRHMQERRLVNISKLLTLCTEDLQKTDAQKTTFCNFKQPQQQKNSGPRTHQNNSEEEEEAEQNIKMNTSKPDALMQGIALKHYQELIPETRAVYISNAAKMEAYKKAYARVLQQLNEATRIHLQQQPTPTWITLTQTGVRLQALTTLNYSMLATQMRMNQEEAMKNSIPKITGRQMIQMRVPVYPARGVQQTTVSQYYAPTLRTPTLVRTESRPLATALELMETERQKDTEDKQAETPEPEIPKAPVSTPDTEEEKDEEKAKDKKEDQDQASTPNQETQGRNNVVEVVEHATPKESTEQREKRVTRSQSRKKQKTEETEFFHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9HY27</accession>
    <name>E9HY27_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733102">
        <property type="protein sequence ID" value="EFX63353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX63353"/>
    <dbReference type="EnsemblMetazoa" id="EFX63353">
        <property type="protein sequence ID" value="EFX63353"/>
        <property type="gene ID" value="DAPPUDRAFT_35911"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_35911"/>
    <dbReference type="eggNOG" id="KOG2206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042387_2_1_1"/>
    <dbReference type="InParanoid" id="E9HY27"/>
    <dbReference type="OMA" id="KFCNVES"/>
    <dbReference type="OrthoDB" id="1115930at2759"/>
    <dbReference type="PhylomeDB" id="E9HY27"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:nuclear polyadenylation-dependent tRNA catabolic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:polyadenylation-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="PTHR12124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="143" mass="16555" checksum="C454E81732287B9C" modified="2011-04-05" version="1" fragment="single">LFQPITSIPLIMVGTKEAFEHLLQDLLSQTVIGVDLEHHSYRSYRGITCLMQISTEKTDYIIDTLKLWDHLQPLNKVFGDPNIVKIFQGADSDVIWLQRDFGIYIVNLFYTLQAASLLGFEKKGLPFLLQHYCQVHVNKKYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZF9</accession>
    <name>E9HZF9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex I-49kD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase 49 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_67608</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL733329">
        <property type="protein sequence ID" value="EFX62871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX62871"/>
    <dbReference type="EnsemblMetazoa" id="EFX62871">
        <property type="protein sequence ID" value="EFX62871"/>
        <property type="gene ID" value="DAPPUDRAFT_67608"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_67608"/>
    <dbReference type="eggNOG" id="KOG2870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_6_3_1"/>
    <dbReference type="InParanoid" id="E9HZF9"/>
    <dbReference type="OMA" id="GIMIADL"/>
    <dbReference type="PhylomeDB" id="E9HZF9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005747">
        <property type="term" value="C:mitochondrial respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="4">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX62871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="100" mass="11018" checksum="D3911AF786584882" modified="2011-04-05" version="1">MRTKRSEMKTSMEALIHHLKLFTQGYNVPPGATYTAVDNPKGEFGVYLVSDGTSRPYRCKIKAPGFAHPAALEKVGRNHMLADIVAIIGTLDVVFGEIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9I1M0</accession>
    <name>E9I1M0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_270996</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733822">
        <property type="protein sequence ID" value="EFX62112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62112">
        <property type="protein sequence ID" value="EFX62112"/>
        <property type="gene ID" value="DAPPUDRAFT_270996"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_270996"/>
    <dbReference type="HOGENOM" id="CLU_2783166_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9I1M0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX62112.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    <dbReference type="eggNOG" id="KOG1217">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cys_repeat_1"/>
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        <property type="entry name" value="Elafin-like_sf"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003242063" evidence="5">
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
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            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="821"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="6">
        <location>
            <begin position="1020"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
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            <begin position="1073"/>
            <end position="1139"/>
        </location>
    </feature>
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            <end position="1437"/>
        </location>
    </feature>
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            <end position="1494"/>
        </location>
    </feature>
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            <end position="1547"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="1118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
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            <position position="1658"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX61998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1658" mass="178371" checksum="22098B64AD296B52" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2B6</accession>
    <name>E9I2B6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
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        <name type="common">Water flea</name>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
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                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
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                <person name="Tang H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="134" mass="15305" checksum="9A94E663BB789D60" modified="2011-04-05" version="1">MDENDNTTFLKSGTQMEQLSYNSTATSGLHCNRMLLQWFNPSSSHLSPFGCNKALPKSELNHLANWFLNDKSPVARMFSETLVGHFVPIRSRRRLLVVTFLTMKIKRYNKTSSMLVVTLLQPNGERCDEDGLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
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    <name>E9I4W7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="2">
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        <name type="common">Water flea</name>
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        <lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Tsuchiya D."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Tsuchiya D."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
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                <person name="Zdobnov E.M."/>
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    </reference>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="subcellular location">
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        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="EGF"/>
        <property type="match status" value="11"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ASX_HYDROXYL"/>
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        <location>
            <position position="1"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000000305"/>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9FU83</accession>
    <name>E9FU83_DAPPU</name>
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        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">DAPPUDRAFT_303260</name>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Cladocera</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DAPPUDRAFT_303260"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="105"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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    </feature>
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            <end position="369"/>
        </location>
    </feature>
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            <end position="54"/>
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    </feature>
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            <end position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="634" mass="72583" checksum="2268B3D3F02A22B0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9FV98</accession>
    <name>E9FV98_DAPPU</name>
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        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88522"/>
    <dbReference type="EnsemblMetazoa" id="EFX88522">
        <property type="protein sequence ID" value="EFX88522"/>
        <property type="gene ID" value="DAPPUDRAFT_41198"/>
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    </dbReference>
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    </feature>
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        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="60" mass="7514" checksum="B4D586A71B060265" modified="2011-04-05" version="1" fragment="single">RRRSRTNFSTWQLEELERAFQASHYPDVFMREALAMRLDLKESRVAVWFQNRRAKWRKKE</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <begin position="1"/>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX88550.1"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX88550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="263" mass="28541" checksum="19FF5E0E1E73D879" modified="2011-04-05" version="1">MVVKNKNEPDPVIITTISTSLFACAGVALSSATISSSSLGVAQQHHGCNTGFDTAGLLTFRQFALASVAQHRAAYRHQAPLMVSTLTYKTGGSRQALIGPTKSPNVSTPNSSRRAPFDRPQRFVSIVTRSALRLLEIIKGTPKGLRRHSSTGVWGLYASRRLWEEDEEIIANRADSASSAAPAAWEGGERFTQATTMKRSHTIVCYTIAYYYYCYTTPGGGGGGDFTRGLYPNAISNSFGYRFVYSHNKNPVTSRRGCCSIPI</sequence>
</entry>
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    <accession>E9FVV5</accession>
    <name>E9FVV5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX89035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX89035"/>
        <property type="gene ID" value="DAPPUDRAFT_310873"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_310873"/>
    <dbReference type="HOGENOM" id="CLU_3052445_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX89035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="54" mass="6326" checksum="9FAC6E79C1B42E7F" modified="2011-04-05" version="1">MSTDPSKKRKDKKKKKAMLEALQQEEYQEERAHVQQLEDVDEDFIVYPADDSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9FVW3</accession>
    <name>E9FVW3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_310883</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX89031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89031">
        <property type="protein sequence ID" value="EFX89031"/>
        <property type="gene ID" value="DAPPUDRAFT_310883"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_310883"/>
    <dbReference type="HOGENOM" id="CLU_2690326_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX89031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="74" mass="8289" checksum="1F7A8ECA57D79B7F" modified="2011-04-05" version="1">MGQRPQKALGCVSLVTRPISASIKLSNLRAEIYLEAGHYLTYSDVIRFEFVMCFNGGELPKPCTKILARQPKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXP1</accession>
    <name>E9FXP1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_42731</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88250"/>
    <dbReference type="MEROPS" id="S01.417"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_42731"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_13_3_1"/>
    <dbReference type="InParanoid" id="E9FXP1"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="PhylomeDB" id="E9FXP1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="49" mass="4974" checksum="6F6BE6DF7DCD3649" modified="2011-04-05" version="1" fragment="single">ICAGAEGRDACDGDGGGPLVCEKEGQWFQVGVVIFGIGCGRTNLPGVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYX6</accession>
    <name>E9FYX6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_43327</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87696"/>
    <dbReference type="EnsemblMetazoa" id="EFX87696">
        <property type="protein sequence ID" value="EFX87696"/>
        <property type="gene ID" value="DAPPUDRAFT_43327"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_43327"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_59_8_1"/>
    <dbReference type="InParanoid" id="E9FYX6"/>
    <dbReference type="OMA" id="KRSQGHV"/>
    <dbReference type="OrthoDB" id="698464at2759"/>
    <dbReference type="PhylomeDB" id="E9FYX6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd14069">
        <property type="entry name" value="STKc_Chk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034670">
        <property type="entry name" value="Chk1_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX87696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="489" mass="55063" checksum="3EBDE0079018ED4D" modified="2011-04-05" version="1">MEDQSKKYEGKNSVIEFVEGWDMIQTLGEGAFGEVKLLVNAKTGEAVAMKVIDLKKHANAAETVKKEVCVHRMLNDPGIIRFYGRRENGNFEFIFLEYASGGELFDRIEPDVGMPQVEAQRYFKQLIAGVSYLHSRGIAHRDIKPENLLLDANDNLKISDFGMATVFRFQGRERHLDKRCGTLPYIAPEVLCRKYAAEPADIWSCGVVLVAMLAGELPWDVPSNDCPLYTSWKECQITRLPWTKIDTLALSLLRKVLMPLPGKRYTIQQITNHQWFQKKFKENMPVSKRLCSDVVDAGLSPPSSDATHLSYSQPGLGFFSGSQPVHQNDTNDDQEPNKHLPGAMFSFSQPAHIDDMLLNSQLNTQTASGSSISSPLQRLVKRMTRLVAKVSCEEAIKHLSQQLIKLGYTWKIHTPGVVTISTQDRRKMQLVFKATVYDMQTMVLLDFRLSRGCGLDFKRHFLAIKHKLADILCSAPVTWSIATATNSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZI0</accession>
    <name>E9FZI0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_312568</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exonuclease superfamily. TREX family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87265"/>
    <dbReference type="EnsemblMetazoa" id="EFX87265">
        <property type="protein sequence ID" value="EFX87265"/>
        <property type="gene ID" value="DAPPUDRAFT_312568"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312568"/>
    <dbReference type="eggNOG" id="KOG4793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067419_1_0_1"/>
    <dbReference type="InParanoid" id="E9FZI0"/>
    <dbReference type="OMA" id="CKGYSLG"/>
    <dbReference type="OrthoDB" id="1365966at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000738">
        <property type="term" value="P:DNA catabolic process, exonucleolytic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="PTHR13058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="3">
        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX87265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="219" mass="24972" checksum="371B6CB8D60E13B6" modified="2011-04-05" version="1">MSSHPQAIKSLVFFDLETTGFKDPEITELSFCSIDRSQFLNCQRGEFPRITNRLNLCIKPSKQIEPKASEITKLDNCNLDHQSPFDEDVGNIVLSFLNRLKKPVCLVAHNGFKFDFPILLAEFSRLYGIMDFPSDIFSVDSLAIFRNLSQSPSSPNLKNIRLSFALKNVYYRIYGRDPEERHEAEADVKVLLLSAIATPEEFVDAVDRNAKPFDFVQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9G0G6</accession>
    <name>E9G0G6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_312322</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87407">
        <property type="protein sequence ID" value="EFX87407"/>
        <property type="gene ID" value="DAPPUDRAFT_312322"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312322"/>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012184_1_2_1"/>
    <dbReference type="InParanoid" id="E9G0G6"/>
    <dbReference type="OMA" id="INAGYMQ"/>
    <dbReference type="OrthoDB" id="1275401at2759"/>
    <dbReference type="PhylomeDB" id="E9G0G6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="334" mass="37987" checksum="977100918C64DB0D" modified="2011-04-05" version="1">MNFLFALMVCAVVVTVVQGQSKEEAWRVYKRKFNKNYQIPADDGKRDRMRKEAFSKSYDRVQKHNSNRMSHYRRKLNRFSDMLPGQLKQFLGINNNSIPTAPPKMSIHPLGMDIITQQNTPSRLDLRYDSCLPEIKNQGQCGSCWAITAVTSVEFAYCKKNNNNSVLLSEQQVLDCDRTDMSIGCRGGWPWDAWEYMSTNGIARTSVYPYKGVDSVCKYVDSMKVTSVRAYNYVESRNVADMQYALTNFGPLVAAMTVVQSFMDYASGVYDDKICDGKLVNHAVVLVGWGNQNGIDYWIGRNSWGPGWGKEGYFLIQRGVNKCQIETYVGYALV</sequence>
</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">DAPPUDRAFT_307799</name>
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        <name type="scientific">Daphnia pulex</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <dbReference type="EMBL" id="EFX86628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="68" mass="8304" checksum="B8D1CDFA2BACC45B" modified="2011-04-05" version="1">MQLSNELVYFHPSRMEKIRNELAHYSGGCIKGYFHRRFHTRLQGEKIFQNCKEQTMTEARERERNCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9G4T2</accession>
    <name>E9G4T2_DAPPU</name>
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        <submittedName>
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        </lineage>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_237928"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:establishment of protein localization to extracellular region"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
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        <property type="entry name" value="Kazal_dom_sf"/>
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    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
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        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
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        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237155" evidence="8">
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            <begin position="21"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="177"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="9">
        <location>
            <begin position="420"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="500"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
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            <begin position="423"/>
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    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="453"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX85353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="519" mass="58267" checksum="919965F0F43EAC56" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9G4Z6</accession>
    <name>E9G4Z6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipocln_cytosolic_FA-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_300446</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85386"/>
    <dbReference type="EnsemblMetazoa" id="EFX85386">
        <property type="protein sequence ID" value="EFX85386"/>
        <property type="gene ID" value="DAPPUDRAFT_300446"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300446"/>
    <dbReference type="eggNOG" id="KOG4015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113772_0_3_1"/>
    <dbReference type="InParanoid" id="E9G4Z6"/>
    <dbReference type="OMA" id="WHSNQYS"/>
    <dbReference type="OrthoDB" id="1417203at2759"/>
    <dbReference type="PhylomeDB" id="E9G4Z6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015908">
        <property type="term" value="P:fatty acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="PTHR11955"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
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        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocln_cytosolic_FA-bd_dom" evidence="3">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX85386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="131" mass="14797" checksum="4D0ABBA240056EBA" modified="2011-04-05" version="1">MAAFLNKKFKLVSSEKFDEYMQELKIGFVMRKLGNSATPVVELTCEGDEYTFTTTTMLKTTTIKFKLGEEFEEERGDGAKVKSTITMDGNKMTHVMKGDPESTIVREFNGDELKAVLTVNDVVCTRIYKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G5Y7</accession>
    <name>E9G5Y7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_222755</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX85089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85089">
        <property type="protein sequence ID" value="EFX85089"/>
        <property type="gene ID" value="DAPPUDRAFT_222755"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_222755"/>
    <dbReference type="HOGENOM" id="CLU_1837085_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX85089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="140" mass="16105" checksum="D694884C86FA2C7F" modified="2011-04-05" version="1">MIKHHFHLLPCYCELLTEKLHTPAVTRQSPQDYAQMVKTVRDVARHRGVKIAWNLSTTKHYHERNEKAAARRVARVSSEFSHSGHFVPRRSQQRWVAALLVVMFLTMKIKSQMVKGVTKTDGTIVCSMRLKCNPEVAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7E8</accession>
    <name>E9G7E8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_99612</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84660">
        <property type="protein sequence ID" value="EFX84660"/>
        <property type="gene ID" value="DAPPUDRAFT_99612"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_99612"/>
    <dbReference type="HOGENOM" id="CLU_1050738_0_0_1"/>
    <dbReference type="OrthoDB" id="1723080at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236723" evidence="2">
        <location>
            <begin position="20"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX84660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="265" mass="29788" checksum="4F1B2278770A837C" modified="2011-04-05" version="1">MERRRRLLLFSLLVSTVVIQSPDGVGSCYLGTFAESLPRTVNWPSASTFLDPWLQIVPFLFHPPEFLDRWAKADFALLHASLSLPCSVLQHQPEVVLLPEAWIEFLPALEDGARYAAVDQQPARPYFDMCDLFGASNISRDSVPGCQNWHHLEAWKRLRIFYDIPSPIRATEAATAHRLQCGESENNSNSSSSSTSGGGGGSNSTWTIPVSSMVKRWMAERSPWTRSNATMPIAIVSRHQSFYGRHHSLLSVQAELHLTYWMDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9G802</accession>
    <name>E9G802_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_46791</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
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        <property type="protein sequence ID" value="EFX84775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84775"/>
    <dbReference type="EnsemblMetazoa" id="EFX84775">
        <property type="protein sequence ID" value="EFX84775"/>
        <property type="gene ID" value="DAPPUDRAFT_46791"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_46791"/>
    <dbReference type="eggNOG" id="KOG1221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024661_2_2_1"/>
    <dbReference type="InParanoid" id="E9G802"/>
    <dbReference type="OMA" id="MESSCIN"/>
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    <dbReference type="PhylomeDB" id="E9G802"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="C:peroxisome"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:alcohol-forming fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="FAR"/>
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        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="PTHR11011"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF51735"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_4" evidence="2">
        <location>
            <begin position="17"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX84775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="198" mass="22545" checksum="9F66D4985326E64A" modified="2011-04-05" version="1">MGHLSIVEFYENRSVFITGATGFMGKVLVEKILRSCPGVERLYLLMRPSKGLSVDYRLREFIQNEIFSKVKEQQPNVLEKVTAVRGDVTLPQLGLSPSDLQLLTENVSVVFHSAATVKFNEELKTALVMNVKGPMELLEICRKMKHLEAFVHVSTAFNNLDREKIKEEVYYNPNVNPVKLIEYLDGLDDQTLQIMTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9G831</accession>
    <name>E9G831_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_238576</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1898312_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="134" mass="14974" checksum="F3EFF90AB0D67256" modified="2011-04-05" version="1">MNEALGDVIVIGSGDILRGFERALSQVTESAQLSVPNEGFWRNYSETDSLESVDSRVYSAVKVDISEWYPSCQLLMIRVLGLTEAVLCVLIVSTMHAIIKTSNALIKKKKITEKQRTTIFCEDWGTSNLSLTNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8H7</accession>
    <name>E9G8H7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_239157</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX83976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83976">
        <property type="protein sequence ID" value="EFX83976"/>
        <property type="gene ID" value="DAPPUDRAFT_239157"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_239157"/>
    <dbReference type="HOGENOM" id="CLU_1596185_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX83976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="167" mass="18909" checksum="40A783D39CB4DB58" modified="2011-04-05" version="1">MKILCIRLKENQHPGCPSRKEEKDKEIIISTAHLRSFLPSLRVVPAPATRPASFDYPTDDWVGQPSLIPITVLNAAQSFNLKIFGSIIVAVCHEFNTADGPDSCMSFTLEGRGEHYTHPQQHQPKEGKPSLHFLHFRRSRRSLRKTCHVTAERLGENDTCNIIIKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9F5</accession>
    <name>E9G9F5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_239471</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83883">
        <property type="protein sequence ID" value="EFX83883"/>
        <property type="gene ID" value="DAPPUDRAFT_239471"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_239471"/>
    <dbReference type="HOGENOM" id="CLU_1837093_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9G9F5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX83883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="140" mass="15682" checksum="92DF0480529013A0" modified="2011-04-05" version="1">MFNFLTGKSAIVKGVANDRGFKTTVTVPGDPFVAEYFSHSNNVKENKRQCATKFLNHLIEMGVVTLDGHRGENFNAYVVSLNAKSWENFIVHNARTKVEHALGILILKKNIESKWTPYIAVMNGWSVSSKQLVKATKIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9F7</accession>
    <name>E9G9F7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_100125</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83552">
        <property type="protein sequence ID" value="EFX83552"/>
        <property type="gene ID" value="DAPPUDRAFT_100125"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_100125"/>
    <dbReference type="HOGENOM" id="CLU_060623_2_0_1"/>
    <dbReference type="InParanoid" id="E9G9F7"/>
    <dbReference type="OrthoDB" id="1139412at2759"/>
    <dbReference type="PhylomeDB" id="E9G9F7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="356" mass="40282" checksum="4D1C552791A9B342" modified="2011-04-05" version="1">MAKNKKRDTRYTKQQLKEAKEREAGNKEPSIDTDTGHEAQNNVEESVASEEPVEEPGQELAPEREPVLDQGPADEEEPIAEIEKETANDEPPVKAKPAFNLRKVTVRLDRLAFNPDGSTKAKKKKAQDADLKGGSSPPEKRRRMTRSTAKTMKNQKGKTFLKDKRYLSLLEFKRSVTTSLLLYGLNAEKARKEDAPEARLMKEIPLSAEPGAKRRKDRLSVPDEIRFSQVGIHHPIFFGNRGRCEWCQATTERRPNGHTKESRPFSQCSMCKIFLCLSKKRNCFLEFHDDRILDPTKAAAETVLAVDPEEEIAVQTVETDPLGIYPSSDSSDDSDFDVLDNDVNDDVLLDEDEWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAJ7</accession>
    <name>E9GAJ7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC protein, subfamily ABCG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DAPPUDRAFT_347377</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83517"/>
    <dbReference type="EnsemblMetazoa" id="EFX83517">
        <property type="protein sequence ID" value="EFX83517"/>
        <property type="gene ID" value="DAPPUDRAFT_347377"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_347377"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_57_6_1"/>
    <dbReference type="InParanoid" id="E9GAJ7"/>
    <dbReference type="OrthoDB" id="1022017at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031409">
        <property type="term" value="F:pigment binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005284">
        <property type="entry name" value="Pigment_permease/Abcg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00955">
        <property type="entry name" value="3a01204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0608">Pigment</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="88"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="122"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFX83517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="682" mass="76246" checksum="79ABE3DEF84F7F30" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAQ0</accession>
    <name>E9GAQ0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_240027</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83503">
        <property type="protein sequence ID" value="EFX83503"/>
        <property type="gene ID" value="DAPPUDRAFT_240027"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_240027"/>
    <dbReference type="HOGENOM" id="CLU_763453_0_0_1"/>
    <dbReference type="InParanoid" id="E9GAQ0"/>
    <dbReference type="OrthoDB" id="266752at2759"/>
    <dbReference type="PhylomeDB" id="E9GAQ0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="313" mass="36475" checksum="3BE13D6CD20EE4BF" modified="2011-04-05" version="1">MTLPIPIPSNVNLQKEKAVCMAFTLGSHGEHYLTGFVMLLNVVSLLAESTTGVPWVWRIQICYAAVFLHQHTQRPVTTPTCNYYTENAEYYKNTQGLYYTEEPKHYSAPSYNRGFCLLHYTNASECYMIIYFALNYYTGAPSDHWCTDVSWLFVDVLLLNLVSLMHMTVVVMFPEYGGFISQRYPCYYTGTSNYYTEKAECYTRTYATPVYYTEELKHYSAPSYNTGSCFPTATLKLRSTTPLKENQFAFMEWYTTLLPYYLTRSTHATPTYYTDARKYYISKATRIIYTNVYAVMSYYEEVSLYPNLHQQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAU0</accession>
    <name>E9GAU0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EOG090X02H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EOG090X02H3</name>
        <name evidence="8" type="ORF">DAPPUDRAFT_315787</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TCO</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAM126 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015131">
        <property type="protein sequence ID" value="SVE84750.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83316"/>
    <dbReference type="EnsemblMetazoa" id="EFX83316">
        <property type="protein sequence ID" value="EFX83316"/>
        <property type="gene ID" value="DAPPUDRAFT_315787"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315787"/>
    <dbReference type="eggNOG" id="KOG4688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_607304_0_0_1"/>
    <dbReference type="OMA" id="VECICKI"/>
    <dbReference type="OrthoDB" id="673408at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018619">
        <property type="entry name" value="Hyccin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220">
        <property type="entry name" value="PTHR31220"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09790">
        <property type="entry name" value="Hyccin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX83316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SVE84750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="451" mass="49229" checksum="1ADB2D867D742779" modified="2011-04-05" version="1">MDEDMRLFISDWLKDAQNDGWSKALSSNSDMMEAIFSLIEEWKSNKDLFNILCIRLFGYYRESNMESKVFSLQFVPSLIYSYLSAIAQGERKDAGSMQTFLLAIYNLEAGGEAQSPKTHSFRVPNIAQPSIYHDTSAIASSSLTESALKRLDPTNRITVKFGPHPHLNSFNAENRLPAMAALLRIYSNYLSMYSKSTLSETCMAFRRLVAQGYTRNSEGSPRIPLSSNLLVEMLHLIYSLTMEDEDLASAARQTLEAVQRRVEMELMAAPILVSAAMADSSHLSIRGEHSSPQLMSTGANGGSARAMWKSMITNASFRTKKLPDDLDITVAQVAEAAAAAAAAAAATPASSSQYQTSPAIHLGAITEENDEPSSGGGGKSSFRLSELVKKKSKPKPARNKANNNGGVIQDGHHAAESNGVISSSTDRNSDSETKEEAELRRRSSEFNGTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9GC99</accession>
    <name>E9GC99_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_316241</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732539">
        <property type="protein sequence ID" value="EFX82895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82895">
        <property type="protein sequence ID" value="EFX82895"/>
        <property type="gene ID" value="DAPPUDRAFT_316241"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_316241"/>
    <dbReference type="HOGENOM" id="CLU_055342_0_0_1"/>
    <dbReference type="InParanoid" id="E9GC99"/>
    <dbReference type="PhylomeDB" id="E9GC99"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
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                <person name="Andrews J."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <sequence length="279" mass="31727" checksum="486129D27674E8E1" modified="2011-04-05" version="1">MFALFGTPKTRPKMIVPYEWILENVEEEPMTITSKMISFGGEKVFRVGLKNYAEYSILFFVVTYLNKIGMEVEDVMYGIQGIGTGPAIMKPMKMENIGYCENLHLFNTILDKKIVGSCTFMFRIVILGNSESYGYRLCDRLAKSQLWAALENQQNLVDVELIVKEKIFRAHKAILAARSSVFAHEFEKIQPGKDGLHQIRIEIEAEPSTMLKFLHFIYTGELLGTLADEKLFKLAHRYNSSTLNTMGETALMEMNATAMAKLMDSLNDEIDAVYPSKIM</sequence>
</entry>
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                <person name="Oakley T.H."/>
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                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="eggNOG" id="KOG1987">
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        </location>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9GCI3</accession>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
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                <person name="Eads B.D."/>
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    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX82644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="299" mass="34296" checksum="8B62D6B4D1B455E3" modified="2011-04-05" version="1">MLCPIEFYEIQDPLQCNIIDVYDESIEKENMLSNAILTREEFLHQLAQLREENKIERLLELEETWSAILRVNDHVKANYAQGLVNEMKIGNLEDKVGGVYHKVEELNGKVDNLSKKCQSLKQRMVEEIPKITEKETMEKTKPTHQLSPCVSNGSSIITLEMADLCANAVINYDVNFKDNTTKKLNSDSQKISSNQNNQTFCCEICGKEYRLRNSLNSHRRKKHSLTSRGRPIGENRPQVEKGFWCTHCNKGVKNMNQFVLKSPSPVQPLPRQWMDSSRTVQKRGKTSPIDFLADPIAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDR4</accession>
    <name>E9GDR4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PBPe domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_241227</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX82128"/>
    <dbReference type="EnsemblMetazoa" id="EFX82128">
        <property type="protein sequence ID" value="EFX82128"/>
        <property type="gene ID" value="DAPPUDRAFT_241227"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241227"/>
    <dbReference type="eggNOG" id="KOG1052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007257_4_2_1"/>
    <dbReference type="InParanoid" id="E9GDR4"/>
    <dbReference type="OrthoDB" id="867715at2759"/>
    <dbReference type="PhylomeDB" id="E9GDR4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240238" description="PBPe domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="4">
        <location>
            <begin position="219"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX82128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="487" mass="55689" checksum="260856BD566B25AC" modified="2011-04-05" version="1">MKENICLLLPHLLDLIILLGYETYETPAVVLNCNGNFRASAHNNFIIFWRFHLPDSSGTVPSERSVVHQSSVGYYRVCWSHLLSNGFSLSPSTAYQSPNLLKGQHLRIIWPRWEGNPKGLSGPVKGGVLINYLAARFNFTYEHVRVTENRLEPTQNGRGLFSYLFDNQSDLIVSAIVPTFSRLKIVDITLPWSYGSYVFLLPIPDESANIYAVAKPFQWPVWLGLIMAIFCVITILNLLQRYLEYRSQFEIDSTPNNLRKLAIVGDIRRPLNRRRRIVAMVGGPCTSNRLPFRLVAGVWTLAAFIFVQAYTSTLFTYVVAPVNHPLIDSLYDIADNPEIHLLVKNEGTPDRYFTAGVYQMDAIKEDYEKTGQCNFQLAKEDFNHFFASMSLPKNSRYTDTINKGLLDLQQTGIIDHWDSWFRTMPRKCMANIKYGYNTETKPSPLTLKNLTGAFVVLLIGSSLSLLTFLCEKILSMRKRHRRRINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9GE15</accession>
    <name>E9GE15_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endoglucanase</fullName>
            <ecNumber evidence="4">3.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CEL7B</name>
        <name evidence="4" type="ORF">DAPPUDRAFT_347625</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="4"/>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="E9GE15"/>
    <dbReference type="EnsemblMetazoa" id="EFX82190">
        <property type="protein sequence ID" value="EFX82190"/>
        <property type="gene ID" value="DAPPUDRAFT_347625"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_347625"/>
    <dbReference type="eggNOG" id="ENOG502QPHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020817_0_1_1"/>
    <dbReference type="OrthoDB" id="875234at2759"/>
    <dbReference type="PhylomeDB" id="E9GE15"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="PTHR33753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241134" evidence="3">
        <location>
            <begin position="29"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX82190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="376" mass="40883" checksum="9ABA3D20062D1BC3" modified="2011-04-05" version="1">MEKHVNRRLVQLLITFLVLVNSALLAEGADENPVVEDRTFGALDFIVQTCSSLGNCQPLTTGLVVDNNWRGVYYNLCYDPKKCDKIPTVNEYQTLFGLTVSPSKTSLTLKYVATAPGPRIYLTTASGPDSYQMVYLLNREISFDVDLSTVGCGLNAAFFFVGMDADGGKAKSGYKGPVYGTGYCDAQLAQTNKPNCYELDIIESNSLTTLLATHTCKGTNNCEPTGCGFMPYPLGKTNFYGRGSSYCVDTTKPFTVTTRFVTVDGEDTGNLKEIQRIYKQNGRTIPNPTVGGNFNSLSDAYCSYYGLNNIGGISASMTQGLKNGMVLTMGLWGDLKNPDFMGWLDKPPYGPCPVYSNSNPNVTYSNIKYGPIGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEA0</accession>
    <name>E9GEA0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_302561</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX82348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82348">
        <property type="protein sequence ID" value="EFX82348"/>
        <property type="gene ID" value="DAPPUDRAFT_302561"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302561"/>
    <dbReference type="HOGENOM" id="CLU_152141_0_0_1"/>
    <dbReference type="InParanoid" id="E9GEA0"/>
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    <dbReference type="PhylomeDB" id="E9GEA0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003752">
        <property type="entry name" value="DiS_bond_form_DsbB/BdbC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02600">
        <property type="entry name" value="DsbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX82348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="159" mass="16846" checksum="DFCD19BB5E5FCBF8" modified="2011-04-05" version="1">MEKILAAADGFAGLLAFSLGISGLAVYSNWTPDNVAVGIWGGIYLLAFAALLFMKMLKKSQIVMGMAVLAALIGATMIGIHSWSIDMYQPLIADCKMYDSINSTLPNSTVTIGEEYPDIFEPVKICDRTVIDSLMLVCGILAVVVNGFIAATASSIASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9GET3</accession>
    <name>E9GET3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_302785</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX81890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81890"/>
    <dbReference type="EnsemblMetazoa" id="EFX81890">
        <property type="protein sequence ID" value="EFX81890"/>
        <property type="gene ID" value="DAPPUDRAFT_302785"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302785"/>
    <dbReference type="eggNOG" id="KOG0894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041481_1_2_1"/>
    <dbReference type="InParanoid" id="E9GET3"/>
    <dbReference type="OMA" id="RPPSIYM"/>
    <dbReference type="OrthoDB" id="1230974at2759"/>
    <dbReference type="PhylomeDB" id="E9GET3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030433">
        <property type="term" value="P:ubiquitin-dependent ERAD pathway"/>
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    </dbReference>
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        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBQ-conjugat_E2"/>
    </dbReference>
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        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX81890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="237" mass="26580" checksum="F232ED22A6F2A9EF" modified="2011-04-05" version="1">MSKHNNSATSRLKQDYLRLKKDPIPYVVAEPLPSNILEWHYVVSGPENSPYEGGYYHGKLLFPAEFPFKPPSIYMITPNGRFKPNTRLCLSISDFHPDSWNPAWSVSTILTGLLSFMLEKSPTLGSIETTDHEKRCLAEQSLKFNLGDKIFNELFPDIAIKIQKEIELRKAAVEMATKSSLPTILSTESGNNPLPFLGDRRVGRVDYPGLLANVVVIAGFTLFAFIVKHVLKSLSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9GFB5</accession>
    <name>E9GFB5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminotran_1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_317235</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX81839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81839"/>
    <dbReference type="EnsemblMetazoa" id="EFX81839">
        <property type="protein sequence ID" value="EFX81839"/>
        <property type="gene ID" value="DAPPUDRAFT_317235"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_317235"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_0_1"/>
    <dbReference type="InParanoid" id="E9GFB5"/>
    <dbReference type="OMA" id="ARFRHFS"/>
    <dbReference type="OrthoDB" id="683031at2759"/>
    <dbReference type="PhylomeDB" id="E9GFB5"/>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034612">
        <property type="entry name" value="KAT_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF6">
        <property type="entry name" value="PTHR43807:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="33"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX81839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="412" mass="46992" checksum="67F0699C5DE27722" modified="2011-04-05" version="1">MSSVNKFSLSDKYKGLDKNVWAEFSNLAVKHDPVNLGQGFPDFAPPKHVTDALADVAKEDNILLHQYTRGYGHPRLTQAVSKLYSNAIGRTIDPFTEILVTGGAFEALFCSIMSCVNPGDEVIIIEPFFDCYEPMVRLAGGTPVFIPLRPKAGGEGHSSEWVLDDAELTSKFTDRTKAIIVNTPNNPLGKVFTQKELEFIGQLCIKWNVLCIMDEVYEWLVYEPYRHFRMASLPYMWDRTVTICSAGKTFSVTGWKLGWAYGPAHLVRNLCVAHQYALHFVVTPIQEAVARSLEMELERLNTDESYFKSLPKLMKSKRDYMAEILVNMNLFLHQADLKKSHIDLSEKKYPEKDYCFAEWLTRVKKLAGIPPTAFYSAENKNLGENYIRFCFIKEDAKLKKTEDILKAWKEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E9GFC7</accession>
    <name>E9GFC7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_195959</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="GL732542">
        <property type="protein sequence ID" value="EFX81616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81616"/>
    <dbReference type="EnsemblMetazoa" id="EFX81616">
        <property type="protein sequence ID" value="EFX81616"/>
        <property type="gene ID" value="DAPPUDRAFT_195959"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_195959"/>
    <dbReference type="eggNOG" id="KOG0345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_4_1"/>
    <dbReference type="InParanoid" id="E9GFC7"/>
    <dbReference type="OMA" id="DRAIHDK"/>
    <dbReference type="OrthoDB" id="973872at2759"/>
    <dbReference type="PhylomeDB" id="E9GFC7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="DUF4217"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="12">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="36"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="237"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="507"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX81616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="594" mass="67092" checksum="3A906A20799970A9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9GFW5</accession>
    <name>E9GFW5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_317407</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732542">
        <property type="protein sequence ID" value="EFX81710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81710"/>
    <dbReference type="EnsemblMetazoa" id="EFX81710">
        <property type="protein sequence ID" value="EFX81710"/>
        <property type="gene ID" value="DAPPUDRAFT_317407"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_317407"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028929_1_0_1"/>
    <dbReference type="InParanoid" id="E9GFW5"/>
    <dbReference type="OMA" id="FKDHQFT"/>
    <dbReference type="OrthoDB" id="517323at2759"/>
    <dbReference type="PhylomeDB" id="E9GFW5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX81710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="543" mass="60567" checksum="10DF67E6C752837E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9GGE8</accession>
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        <name type="scientific">Daphnia pulex</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the RGS7BP/RGS9BP family.</text>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PhylomeDB" id="E9GGE8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="GO_Central"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX81392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="111" mass="12770" checksum="CC4BC45258066AD6" modified="2011-04-05" version="1">MCSDIAAGIPLDKDHVIHFFCSCQLLVRELHKSHRLIQRKPLDMTSFYENRAGPSNLGTVFSQIILCKQLAPDFNAEELRSIRKDSEDIQRLIDDLSEFMPIEESHGRNNN</sequence>
</entry>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732543">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_102482"/>
    <dbReference type="HOGENOM" id="CLU_1361662_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GGJ7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="201" mass="22896" checksum="E91E1D281800C5AF" modified="2011-04-05" version="1">MAFSSFSLFSPFSQWLNQTFGGFVYPNNNQPECGSPIDLINDNVCHNIMFEFPAEKMEVCPRGGTKRKSEDDWSISNPANSTNMPDSKKICLLVALPDEKRKKILSPGNKRRRSAAARATRAATTSPEVGEASRWTVPVVHHQWVVQSHPNHWPDLIYSPPSFRPDYSRPPPVQHRPFHIYYSSIIAQEPQQLMDVDPEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GHG1</accession>
    <name>E9GHG1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_224346"/>
    <dbReference type="HOGENOM" id="CLU_1134548_0_0_1"/>
    <dbReference type="OrthoDB" id="1794173at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240341" evidence="1">
        <location>
            <begin position="17"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="232" mass="26140" checksum="3D7DAA34D27B053F" modified="2011-04-05" version="1">MNIAVILSLLVAYVMAAPAANPQFPASYYLMEYPVSLGENTQIRSLPAITGTLTDTTQSIASWQLLQLRRKWIMIICLMDPKCPSLEFPTKHPWAPARNYPLQFNSAFDKWAAQYSDILAPGPIIRNDAQDPFYPGIPYRTIPVTEDAAEAKSTSMLTSAANFQMSQWIWRWNIILCLVNPSCPHVNIPSTTVRTRNGYPGYPSFRVDMETLRAMNQDQRRGVVIPVSFAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9GHH0</accession>
    <name>E9GHH0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
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            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
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        </source>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
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                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="EFX78845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="80" mass="9170" checksum="B0D23E7340193297" modified="2011-04-05" version="1">MKDCMMKNNSRDADGNENKCWRYSILEANVTSLEDAGPKFPGLISYALRGVYELNCIDIIAACTRPTSILPMEYNKFYYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPN4</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">DAPPUDRAFT_320366</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
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                <person name="Choi J.H."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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                <person name="Choi J.H."/>
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                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <name type="common">Water flea</name>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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            <begin position="16"/>
            <end position="324"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="324" mass="37156" checksum="5EA66838C186FC02" modified="2011-04-05" version="1">MIFPTFLLALLTVRARDHCREEYELYVSCVAAILVRVCMVKYSLLKYQQIWSQRTHPHKRRQPACPFLSKVTPSWRSLLNYNVVLLSDIVVSLMAGSTTSLPMSFEHEYQSAMPTPYYTTTAYASAGYYTIKSPGNYTTTYDPTSYCTDALPIPISDVNLQKDRPVCFEGHGNHYHYSAPSYNRGTVYYTNIDPDCYAAPNRYIEAPKYYTIEDYYDVMLLLGVVSLMAGSMTISTHYIDACKYHISKATRVIYTNIYASSSYCTEVSLYPKSHQQNEYYTGDLKYYTTKATKYCTTSYAVLGCYTDVSKYCSDYRQYTEAAAY</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX75175.1"/>
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    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_250860"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_250860"/>
    <dbReference type="HOGENOM" id="CLU_2690341_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="74" mass="8448" checksum="F24C91BAF3A908A0" modified="2011-04-05" version="1">MKLIETYERLNVGQEPQNEEEVGKIEEAIRYLNDQIRAFQETMPANAKAILSWQFPPSCKILRVLKLGGGISKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9H159</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX74582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_108783"/>
    </dbReference>
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    <dbReference type="PhylomeDB" id="E9H159"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="202" mass="23500" checksum="8C834D46756D5F8B" modified="2011-04-05" version="1">MAKSFNSTRNLTGGEYKQKLYFVPCADNKPKVGHEISEPAIFRFLLNEETLEKFDEAAEVEIAEMLEILKDIDKRSKITQVEAYQSSMNPVTNAVKAYHVFIVFKSTSETADDEVYYWWSLEKGTDYITLQRSRNKENVKDKLKGEERKKVKPIKEDLKGKDDSRKVPSLEIQLPVLGHFHQQTYYSRSIRMQKFFPVLCSS</sequence>
</entry>
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    <name>E9H2V3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
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    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX73946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73946">
        <property type="protein sequence ID" value="EFX73946"/>
        <property type="gene ID" value="DAPPUDRAFT_252512"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_252512"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094357_1_0_1"/>
    <dbReference type="InParanoid" id="E9H2V3"/>
    <dbReference type="OMA" id="NIYNIRH"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="PhylomeDB" id="E9H2V3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
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        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX73946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="189" mass="20839" checksum="159787A1C18CA7C7" modified="2011-04-05" version="1">MTSPPNIICFQETWLDESKEFEIDGFDHIRADRRDRIGGGVATFVAIGTPFRQIDLPPSTLEAVAVEVFTDEKSISICNIYHSSQENDVQVFENILRDLPPDSTPFLCGDFNSHHEMWGGKKNDHKGFSLVSFIEENGLVALNDGNITYRSSSGASSVLDLTITTADIAAKCSWSVVSESTFGSDHHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5B6</accession>
    <name>E9H5B6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_253665</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732593">
        <property type="protein sequence ID" value="EFX73104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73104">
        <property type="protein sequence ID" value="EFX73104"/>
        <property type="gene ID" value="DAPPUDRAFT_253665"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_253665"/>
    <dbReference type="HOGENOM" id="CLU_903888_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX73104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="308" mass="34650" checksum="A558A7EFAAECB4B8" modified="2011-04-05" version="1">MKTPRCKFVFINPEKLTEVIERSWRPKECETIDAHLVKFGFSAAAYHAGITDDRFQESKEIEIKALMEILCFCEYEVVVKNSVTLIREVFQPPNKNACVEHNSNSEFDMTCVFAEGECYQFIVIGMTAAVDPPDGPERRDADLDQHREATDDSYGHGPVKAPARARGPQWPERKLQRKKGNLEEDKIKADSTEGKNKRVWAPVFAFCQAAFQRESISDRNTLFLCRPRGMPAGASDARILAEIPPATCNDEGGRRAARREDVGENEGRVSRRGFEQSANGQRKRTLGGFQGCNYTFPVDGRSPNRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5J8</accession>
    <name>E9H5J8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_58280</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732594">
        <property type="protein sequence ID" value="EFX72990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72990"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_58280"/>
    <dbReference type="eggNOG" id="KOG3489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141397_1_2_1"/>
    <dbReference type="InParanoid" id="E9H5J8"/>
    <dbReference type="OMA" id="DRNTEAC"/>
    <dbReference type="OrthoDB" id="1593287at2759"/>
    <dbReference type="PhylomeDB" id="E9H5J8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039238">
        <property type="entry name" value="Tim8/13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19338">
        <property type="entry name" value="PTHR19338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="SSF144122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="zf-Tim10_DDP" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX72990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="72" mass="8540" checksum="7C75E356392B5827" modified="2011-04-05" version="1" fragment="single">QRILMREQQRAQFQQQINKFNDICWETCIDKPTSKMDNKTETCIVNCVNRFIDLNLLCAQRFAQILQQNGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9H7A9</accession>
    <name>E9H7A9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_110838</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732600">
        <property type="protein sequence ID" value="EFX72399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72399">
        <property type="protein sequence ID" value="EFX72399"/>
        <property type="gene ID" value="DAPPUDRAFT_110838"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_110838"/>
    <dbReference type="HOGENOM" id="CLU_1002075_0_0_1"/>
    <dbReference type="OrthoDB" id="701388at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX72399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="278" mass="31934" checksum="AD122D78B0F25D6C" modified="2011-04-05" version="1">MSKQEFASLSECDKPLRLKTPGGRRLCWIKKYNASIKSCKKQPKIRKKLSWKQDGTKLSWQKLFANLNQAEKKFQQLEKRYDQLKESLDLLKGGMVRANQEHKDVVSERDKLKAKLPLLEMAPHAECSSNAFYDLSINFSPTENVRIDEVASDEPPSTLVMDKQRWYTDHEMVTLFSLANFLNQLKKSGILLEKVTYISKGVEISIGTEQTGVITNFTIFGVDEMMESIRFYKAEDKEDIPNCKLPNVDGYISGMTKDATTRLLRNLNERKIQAGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9H7M6</accession>
    <name>E9H7M6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_308332</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732601">
        <property type="protein sequence ID" value="EFX72280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72280">
        <property type="protein sequence ID" value="EFX72280"/>
        <property type="gene ID" value="DAPPUDRAFT_308332"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_308332"/>
    <dbReference type="eggNOG" id="ENOG502S4KI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075165_4_1_1"/>
    <dbReference type="InParanoid" id="E9H7M6"/>
    <dbReference type="OMA" id="YTADNEG"/>
    <dbReference type="OrthoDB" id="1583175at2759"/>
    <dbReference type="PhylomeDB" id="E9H7M6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240903" evidence="3">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX72280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="122" mass="13271" checksum="7EAEA99E2FD38F14" modified="2011-04-05" version="1">MNKFIVLATLIAAAVAADIYPKPSYPAPAAAAGYAKPAEEYPPMPYSFDWAVKDEPSNNDYAHQEASDGKVVTGSYRVALPDGRTQIVTYKADENGYVADVKYEGEAKYPAPESYNKPAPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9H8W3</accession>
    <name>E9H8W3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_326826</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732606">
        <property type="protein sequence ID" value="EFX71790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71790">
        <property type="protein sequence ID" value="EFX71790"/>
        <property type="gene ID" value="DAPPUDRAFT_326826"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326826"/>
    <dbReference type="HOGENOM" id="CLU_2869870_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX71790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="64" mass="7179" checksum="32E9EB938257641A" modified="2011-04-05" version="1">MEEKYNVSLLAAGIHCEAQQLIAEKVDELLAIEEQIDFNVLSLETCAYSANMFADILSKIQKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9T2</accession>
    <name>E9H9T2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_308807</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732609">
        <property type="protein sequence ID" value="EFX71454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71454"/>
    <dbReference type="EnsemblMetazoa" id="EFX71454">
        <property type="protein sequence ID" value="EFX71454"/>
        <property type="gene ID" value="DAPPUDRAFT_308807"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_308807"/>
    <dbReference type="eggNOG" id="KOG0863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_8_0_1"/>
    <dbReference type="InParanoid" id="E9H9T2"/>
    <dbReference type="OMA" id="NTQVYGK"/>
    <dbReference type="OrthoDB" id="1222564at2759"/>
    <dbReference type="PhylomeDB" id="E9H9T2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF12">
        <property type="entry name" value="PTHR11599:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX71454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="285" mass="31705" checksum="58B5497C3C4DB080" modified="2011-04-05" version="1">MFRNQYDNDVTVWSPQGRIHQVEYAMEAVKQGSATIGLKSKTHAAIVALKRATSELSAYQKKIIPIDTHMGMTIAGLTADARFLSRYMRTECLNHRYSHDEPLPVSRLIGNLGNKLQVCTQRYDRRPYGVGLLVAGYDSKGPHIYQTCPSATYFDCKAMAIGARSQSARTYLEKHLNEFMECSVEDLVRHGLRALRDTLPNEVELTSKNVSIGVVGKGMDFTIYDDGGVESFLAGLDKEDRRGGRPLPPDVEEELKEVPIGESPAPDQDPVMAVEMDVEQHSGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9HC11</accession>
    <name>E9HC11_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_3267</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732618">
        <property type="protein sequence ID" value="EFX70687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70687">
        <property type="protein sequence ID" value="EFX70687"/>
        <property type="gene ID" value="DAPPUDRAFT_3267"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_3267"/>
    <dbReference type="eggNOG" id="KOG3700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007874_0_0_1"/>
    <dbReference type="InParanoid" id="E9HC11"/>
    <dbReference type="OMA" id="INILLWA"/>
    <dbReference type="OrthoDB" id="1171418at2759"/>
    <dbReference type="PhylomeDB" id="E9HC11"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX70687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="354" mass="40977" checksum="80E8314CD1D7BBEE" modified="2011-04-05" version="1" fragment="single">TVSVDTFFLMSGLLVSYLLLRELDRSGGKFNVALFYLHRYLRLTPVYAVILGYIATLIIYLGTGPNWYNVVLASDGCRVTWWKQFLYINNLFPNDMNSQCMGETWYLAVDMQLFLVAPLIIYPLWRWKKSGIILLSAFTLATVAANFAVYALYNLPPSLMATRMQEMTKFTTDYMDNYYFKPWTRAPPYLIGIWTGWFLHRVKQSKLRISPWIVALFWTLSVVIAASIIYGLTPYVNEELVPTINWAVKMTYGPLHRTAWALALGWIIVACIHGYGGFVNRFLSWRGFLPLSRLTYCVYLIHYDYLNVFYSLSRKMIYYTFVDQLTTFFGITVTVFGLAFVVSVCVEAPFINLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9HC54</accession>
    <name>E9HC54_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_327911</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RUS1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX70716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70716">
        <property type="protein sequence ID" value="EFX70716"/>
        <property type="gene ID" value="DAPPUDRAFT_327911"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_327911"/>
    <dbReference type="eggNOG" id="KOG4249">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1035357_0_0_1"/>
    <dbReference type="InParanoid" id="E9HC54"/>
    <dbReference type="OrthoDB" id="1357597at2759"/>
    <dbReference type="PhylomeDB" id="E9HC54"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
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        <property type="entry name" value="PTHR12770"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="269" mass="28983" checksum="33BB202F07B10A88" modified="2011-04-05" version="1">MKIWENYSIHAIQAFVGSLSGSLSTRAILEGVGVGSSTSTPLAATLMWLIKDGSTRMVGRILFAWCNGTKLDADTAVGGSNGTMTSILCVAGVAKSIVGVAGGATRAALTQHQARQGNLADVSAKVEAKKPCQVLSNFISPNRLEPVIMGLIPTEEDVCCCRIQLGCSIKAVASRSIFEKQLAHYSERNFAVIPDLLTKTIYVIYRRDCKVEDMLKSYSQAILSSMLSSGYSKIMDLDPPLDGDILNALNQLEKSSYWKELRQGLVNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCB8</accession>
    <name>E9HCB8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_309386</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX70596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70596"/>
    <dbReference type="EnsemblMetazoa" id="EFX70596">
        <property type="protein sequence ID" value="EFX70596"/>
        <property type="gene ID" value="DAPPUDRAFT_309386"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309386"/>
    <dbReference type="eggNOG" id="KOG3513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005756_1_0_1"/>
    <dbReference type="InParanoid" id="E9HCB8"/>
    <dbReference type="OMA" id="AGRGDYP"/>
    <dbReference type="OrthoDB" id="434404at2759"/>
    <dbReference type="PhylomeDB" id="E9HCB8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
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                <person name="Tokishita S."/>
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                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Dong Q."/>
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            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine</text>
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        <location>
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        </location>
    </feature>
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        <location>
            <position position="124"/>
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        <ligand>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX70215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="300" mass="34635" checksum="F3C21B228565146B" modified="2011-04-05" version="1">MEAEIELHFLKKFQFKQLVQSSWSCRNPFGNCSWKIPELESLKYHLNCTKGLLSHMEASTWHDHTNYTNHAADIFHKVKCDINPELLTQAWLKFYECLAQFDLVGELPQHSSVFQSVHLCEAPGAFITSLNHFLQLRYPFLELKWSAITLNPYYEGNFRKSMIGDDRFISSTLKHWNFGIDDTGNIMEWCNVKAMLKKPHHQVNLVTADGSVDCADNPGEQENYLAPLHWCETISALLILSNGGSFILKMFTLFEHTSVSLLYLLMISFEELHVFKPCTSKEGNSELQVYERCVLTTFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9HFV0</accession>
    <name>E9HFV0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TRC8_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_329161</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732637">
        <property type="protein sequence ID" value="EFX69382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69382">
        <property type="protein sequence ID" value="EFX69382"/>
        <property type="gene ID" value="DAPPUDRAFT_329161"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_329161"/>
    <dbReference type="HOGENOM" id="CLU_1512115_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HFV0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025754">
        <property type="entry name" value="TRC8_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13705">
        <property type="entry name" value="TRC8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="TRC8_N" evidence="3">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX69382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="178" mass="20529" checksum="C3A3244140170456" modified="2011-04-05" version="1">MNKATKEHEIQRKWEIASMCYYLLVAHYISVGLMNYNLVCKVVKGQIARIIWGIRNDGILAFFESERLRLNIPLIFRSFWLMRCGIHMYIYLVSSEFAWTDVESLNTLLKLVMVRGCETLPALLGMASVFSWICAKVYLKSQEFMQIPDERSTHIGPLIAATLFCQPGFYTTRKSSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HG50</accession>
    <name>E9HG50_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_113800</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732639">
        <property type="protein sequence ID" value="EFX69247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69247">
        <property type="protein sequence ID" value="EFX69247"/>
        <property type="gene ID" value="DAPPUDRAFT_113800"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_113800"/>
    <dbReference type="HOGENOM" id="CLU_561719_0_0_1"/>
    <dbReference type="OrthoDB" id="1105506at2759"/>
    <dbReference type="PhylomeDB" id="E9HG50"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX69247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="443" mass="50155" checksum="5FA91938E748B32B" modified="2011-04-05" version="1">MSGQQSRSSKRIQGIAASPPRPLVTRRTTSQSEREETEHTAPRTEPGENLEKIPAETSTRQKCKFTSQAGKRHPPGDQEATGSTDATRPRATQKHDAKACSHKGRDSGFADKSQADCTTQESPTTDQTTRRRPTHEEANDDDEDELYTPVRLWTQRAAGLHPEPTETELSYTFLSSESEEDPDSTEVRDSTEGAVDLLTSFLNTTPSNGSEERHRSRKEEHHHNRPEHPPYHPRQEERRRSRQEEHNPQEEQHNTQSSPPTGGTAQHPTRTPTQPPAQPHQPHRQPRPPALPTRNMAAGLIKFKAPPVFSGKAGEDAADWMDRYEILADYNRWTDADKRTNFGIYLEGPARQWFQCLTPPNDWGDTAAVAATQQQAATPAISGMRSIFIREFLQDSYAGYQESRMRKRKQGINEPAAEYYYEIINLCRLMDPNMSEEAKLHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGI8</accession>
    <name>E9HGI8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lon N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_259078</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732642">
        <property type="protein sequence ID" value="EFX69089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69089"/>
    <dbReference type="EnsemblMetazoa" id="EFX69089">
        <property type="protein sequence ID" value="EFX69089"/>
        <property type="gene ID" value="DAPPUDRAFT_259078"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_259078"/>
    <dbReference type="eggNOG" id="KOG2004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_1_1_1"/>
    <dbReference type="InParanoid" id="E9HGI8"/>
    <dbReference type="OMA" id="YEIDSAR"/>
    <dbReference type="OrthoDB" id="528132at2759"/>
    <dbReference type="PhylomeDB" id="E9HGI8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJH9</accession>
    <name>E9HJH9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_330412</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732662">
        <property type="protein sequence ID" value="EFX68127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX68127">
        <property type="protein sequence ID" value="EFX68127"/>
        <property type="gene ID" value="DAPPUDRAFT_330412"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330412"/>
    <dbReference type="HOGENOM" id="CLU_1043013_0_0_1"/>
    <dbReference type="OrthoDB" id="1494583at2759"/>
    <dbReference type="PhylomeDB" id="E9HJH9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX68127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="267" mass="29842" checksum="6A457C4F540CF472" modified="2011-04-05" version="1">MSTLNGKHIPLSTTLNRKNRNLFLKKSFVSLALDIDSQDWEELRDRFLEAIDLIKVVDQECNSLKGELASTKSSFDQYRIAFADKMFTPISTHPIIQHAPGPVSQNQPNHASTLIISTSDNATDMDLKELDAILGSAEKGPVTETFSKKGNIVYASYKSALESGRTKAILEAKPNLVRTIHTKDIFYPAIALNINVSDLPTLHKELVLRNDFIGSSLKKIIPIFKSKVNPEVGHVKLLFDSASIRKRIIERQNVCAFGRKFHAVELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9HM52</accession>
    <name>E9HM52_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_64062</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732684">
        <property type="protein sequence ID" value="EFX67200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_64062"/>
    <dbReference type="eggNOG" id="ENOG502RXG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080814_0_1_1"/>
    <dbReference type="InParanoid" id="E9HM52"/>
    <dbReference type="OMA" id="QRTEKYS"/>
    <dbReference type="OrthoDB" id="1489926at2759"/>
    <dbReference type="PhylomeDB" id="E9HM52"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:endoribonuclease activity, producing 5'-phosphomonoesters"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="132" mass="15134" checksum="4D8CF71E3A7533AB" modified="2011-04-05" version="1" fragment="single">QLLSHIKSARKSIDIAVYCISCFEIADVVLQRHKVGVRVRVITDQSMEIAFGSQNHRFMKDGIRVHTNKPPFLMHHKFFIIDDELLCSGSFNWTSQAVTGNNESVIITNDPWTVEPFCAEFQKLWQETKPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9HP63</accession>
    <name>E9HP63_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear envelope membrane protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nuclear rim protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_229408</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nurim family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732703">
        <property type="protein sequence ID" value="EFX66455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66455"/>
    <dbReference type="EnsemblMetazoa" id="EFX66455">
        <property type="protein sequence ID" value="EFX66455"/>
        <property type="gene ID" value="DAPPUDRAFT_229408"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_229408"/>
    <dbReference type="eggNOG" id="ENOG502RS62">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083708_0_0_1"/>
    <dbReference type="InParanoid" id="E9HP63"/>
    <dbReference type="OMA" id="WSIWFPL"/>
    <dbReference type="OrthoDB" id="1048330at2759"/>
    <dbReference type="PhylomeDB" id="E9HP63"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033580">
        <property type="entry name" value="Nurim-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31040">
        <property type="entry name" value="PTHR31040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX66455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="265" mass="31123" checksum="F4CBE4ED95EAC969" modified="2011-04-05" version="1">MIFSTVFPIAYCTFVITLSGFTMWKLMWSVSNIQLSNENDTSQPDQGLFFPMWLNAGLVALFVTQHSYLKTSQIGDYLRRHRITSSISRSIYVILTSVALQIIMALWTPITSYCLWRLNTDGSLLWWIFATIHVLSWACIYGGSVLLDLPDLVGIRQIYYFCLNLAETSDLKSTELQRLYSHKRHPGFMGILVLLWITPFMRHFVFSLDRFLLALAFTVYMAVAWEPTVDDRRYHQRQLERKQHEISYSNRRKQMQNSEFRNFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9HP75</accession>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="10" type="ORF">DAPPUDRAFT_64670</name>
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        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732703">
        <property type="protein sequence ID" value="EFX66469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66469"/>
    <dbReference type="EnsemblMetazoa" id="EFX66469">
        <property type="protein sequence ID" value="EFX66469"/>
        <property type="gene ID" value="DAPPUDRAFT_64670"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_64670"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074675_0_0_1"/>
    <dbReference type="InParanoid" id="E9HP75"/>
    <dbReference type="OMA" id="CEALHAD"/>
    <dbReference type="OrthoDB" id="395903at2759"/>
    <dbReference type="PhylomeDB" id="E9HP75"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071797">
        <property type="term" value="C:LUBAC complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
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    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="33"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX66469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="263" mass="29389" checksum="D7B6FBBDE606D802" modified="2011-04-05" version="1">MDPLDPAVTDEPKADYKKLVDLLDGSDVVTNADPFDCPVCLMTVPAGVGVTLRECLHNFCRDCLAHVIEFSDEATVTCPYRDDRYACDAILQELEIKNLVGAKLYEKHLERSMRLAEKAMANTFHCQTADCPGWAVVEADNVNVFRCPVCRQSNCLTCQAIHEGVNCKEFQDRVNQTAETDDDARRTKEMIDALVASGEALSCPQCQVVLMKRWGCDWVRCSVCRTEICWVTKQNRWGKGDTSGGCRCGVDGVKCHPFCNYCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPF2</accession>
    <name>E9HPF2_DAPPU</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66382">
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_116453"/>
    <dbReference type="HOGENOM" id="CLU_1490489_0_0_1"/>
    <dbReference type="OrthoDB" id="1776004at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX66382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="181" mass="20812" checksum="5AC27BAC087D7D3E" modified="2011-04-05" version="1">MALNHYRNLKETADKFKGSEGTDKLTMNKTVDVLNGRYFAEGISNNIIHNDKNNRAVEDMKWATLNAILTVLDITEKERESRLTGKTNHDPNEEIEEDGKQAKLTVKDKLLTVLSIRYGDHIENQVSSSDVTNDELIYDICGYLPHSGSQVLECLDCVEWEKVVVELQNRFSEYVRVVWEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPY6</accession>
    <name>E9HPY6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_64920</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732712">
        <property type="protein sequence ID" value="EFX66203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66203"/>
    <dbReference type="EnsemblMetazoa" id="EFX66203">
        <property type="protein sequence ID" value="EFX66203"/>
        <property type="gene ID" value="DAPPUDRAFT_64920"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_64920"/>
    <dbReference type="eggNOG" id="KOG0224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_9_0_1"/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Basu M.K."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
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                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="154" mass="17714" checksum="59702C42696DBA67" modified="2011-04-05" version="1">MANTNKEFPEGSQTGQQPSLDFIMSLSNLFQQVMGPEHTTIALPTHNAFKDVGHIVKFNGENYSDYRCEFLSMMEQLGMKTMVRINNIVTIQVAIDAWLLRDVTCRNYILSTNEQNQKKNLYGLLTAREMWLKIETQYASNAADLENNWKDIDN</sequence>
</entry>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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    </evidence>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="gene ID" value="DAPPUDRAFT_118125"/>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003242109" evidence="1">
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            <begin position="30"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX64483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="388" mass="44082" checksum="E291FE0A8704BC46" modified="2011-04-05" version="1">MVGPNRHNDGAQLLLLVAAFNSLSFPSLAGSLYEVGNNTSKYWTLFILMNIANDKDRLFLFMSDLSQLSRTLLSVLNEWRKSNKSCLFSLSRLTCEEKFKDAGIKFTFGEYSLNGNIRKLINSYYDWGELLAVAPRAVSGLERLIGWSHHPKMDFPIDDKVTPIGGFTHINAHQVPGEFPNDFTSNWSSRLFGLTESSHEYRQDPDVQFERIQSYQGCRSVIDVITETLVFGSTRYQNQQKRWSWKELDSNGVGSSVVKKPRMQSTPQKEETLEVIQALQEGVEDELTNLKTDWMELKDFYSKMNVFAAKATENSIVFIEVVIRVIARDLNVLGDDEIFGNLLEKIQRANEASFLVRGVSDMYVNVSIKYIMDQIASQGDIMASIDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9HVA5</accession>
    <name>E9HVA5_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_118288</name>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732847">
        <property type="protein sequence ID" value="EFX64325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64325">
        <property type="protein sequence ID" value="EFX64325"/>
        <property type="gene ID" value="DAPPUDRAFT_118288"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_118288"/>
    <dbReference type="HOGENOM" id="CLU_111286_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HVA5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX64325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="162" mass="18494" checksum="8A8BA62CABE16FDE" modified="2011-04-05" version="1">MNIILTIINLFFIRLMSLVFFISPAAFDYLWEAFANYFLDDFAESPPIFTESELTTASNATKTEVAEPEFCSCCEEEYQNRIFLNQLELEVQKVSDEQNQKNRRNATEPNSDSEESNYEDEPSAKQENNEAEAESPSISESSKVIPPTERPTPSQMASLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9HVB7</accession>
    <name>E9HVB7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_266634</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL732848">
        <property type="protein sequence ID" value="EFX64296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX64296"/>
        <property type="gene ID" value="DAPPUDRAFT_266634"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_266634"/>
    <dbReference type="HOGENOM" id="CLU_022631_1_0_1"/>
    <dbReference type="InParanoid" id="E9HVB7"/>
    <dbReference type="OMA" id="YTIGRFS"/>
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    <dbReference type="PhylomeDB" id="E9HVB7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="474" mass="51024" checksum="5423166676307EAA" modified="2011-04-05" version="1">MIYRISITVFLVLSILTQAGRACNDIPEDQPTFRENSFVNDVDPSTHQLAASDVNPWLPYYYDDQTHGRTLGGNRAESGESQQIENRAVFSVFPSRLFGNGNIANSFNFNPRSLFGKSSTSAVFPYDSCSSPNGVMGVCATAGICTQLSGTASGSCAFGSVCCINVATNCGGTVSLNNTYWQSPTNGISTSTTSCALTIKLDTKLTEQKRPICQVRSFTISQPDAQSLCTNGDFFDVGGQTNKVPTICGDNEGQHMYLNVPSSATNPTDLELAFTFGPTAATRVWNILISMLPCDANYLAPVDCLQYFPTRSGRVRSFNWRDVAGTATRQLANQDYSICFRRASSNTGRLCFTTCVVTSSQQPFSLSVARSLLGAALVGNSQIISTNCNNDYLIISGGYDPTNPNPNPPVTDMAFDRFCGERLNPQPSNGASVTVCTTITPFRISYRTNGDETTTPTSDVAGSGNSGFCLNFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HVP3</accession>
    <name>E9HVP3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732865">
        <property type="protein sequence ID" value="EFX64179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64179">
        <property type="protein sequence ID" value="EFX64179"/>
        <property type="gene ID" value="DAPPUDRAFT_118424"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_118424"/>
    <dbReference type="HOGENOM" id="CLU_886406_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX64179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="314" mass="34870" checksum="B9DE3335F799B78A" modified="2011-04-05" version="1">MGRYLLSCAELDVLGFPRPAADGCGSAVHSSVSTIAEYVVNDTNSVTCDIWEDKKDIDNSSPPLRLPSPIPYTSTGMQVLQATTFAKVKIAQEASNSGTDDDFVEMFSSPPLRQTSTKKRLSLPKKTHLSCKHATNDAEVHSSVIGTKNFTGKMRYGGWVFSFDFKEPRMVELVMVGGRKLRSVGPKKIEAPLRSEEIDGLVDVEFYSIFEVETLAVEEKKSTIKREGRESISAQMALILSTGIHHSPQITDPKHVCIDEWATFRFSYHGDDHIHYRPCPVRPDVPFPAAVEDLGQLGFGNGQSREIWPRLPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HWC0</accession>
    <name>E9HWC0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CxC3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_267347</name>
        <name evidence="2" type="ORF">DAPPUDRAFT_267353</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732912">
        <property type="protein sequence ID" value="EFX63955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732912">
        <property type="protein sequence ID" value="EFX63960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63955">
        <property type="protein sequence ID" value="EFX63955"/>
        <property type="gene ID" value="DAPPUDRAFT_267353"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63960">
        <property type="protein sequence ID" value="EFX63960"/>
        <property type="gene ID" value="DAPPUDRAFT_267347"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_267347"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_267353"/>
    <dbReference type="HOGENOM" id="CLU_2815040_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040564">
        <property type="entry name" value="CxC3-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18804">
        <property type="entry name" value="CxC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC3" evidence="1">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX63960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="67" mass="7584" checksum="B4445AAE21B15D8E" modified="2011-04-05" version="1">MYNEDTSMIFKPEEFISCGDVVTCGRFDLHFPQFTCAECGEQQCANEADFVVSGWWPSLAKNGSYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HY43</accession>
    <name>E9HY43_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_119296</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733108">
        <property type="protein sequence ID" value="EFX63338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63338">
        <property type="protein sequence ID" value="EFX63338"/>
        <property type="gene ID" value="DAPPUDRAFT_119296"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_119296"/>
    <dbReference type="HOGENOM" id="CLU_1210872_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX63338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="229" mass="25129" checksum="F73F82E0EB212C61" modified="2011-04-05" version="1">MTTLYGLLLRDISISLGADQTLEGKPNIAGFILCMPLFFMEYTHLIWISFLVKVGSTSHRQSRQIDKGLGLAGKNSLFSVKQLIDKILVYVLKKQDLKFASSVGFLKLRAQRLNSGGSSRRTCFPTLNANHILPVQISREEGGSSPCSNVLAKPTLVSWAPLIDDPNTSDDGIEQVPINGFSDQEAMVETVALILSGWKLPGEFSLTKEFRLKLGKLLLAGNRNSTFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9HYP2</accession>
    <name>E9HYP2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_335890</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733197">
        <property type="protein sequence ID" value="EFX63139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63139">
        <property type="protein sequence ID" value="EFX63139"/>
        <property type="gene ID" value="DAPPUDRAFT_335890"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_335890"/>
    <dbReference type="eggNOG" id="ENOG502TB6Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049663_0_0_1"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="PhylomeDB" id="E9HYP2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="390" mass="44748" checksum="4ABE0A29CCC21F4F" modified="2011-04-05" version="1" fragment="single">MILTKQSEKVDDRMEGVTIDPPKEKLGTPGFLKNIGAIFKEVEEDEQRLGADLRADSEDGDDESVDEAGPSKPVKRNRNLRVKGQPPTRISTRIRGEPPAPLENEHIEINVLVNQTETVINEQENLSIINEVSRAKSSDSESDEEEITVNRKNLTKRVKQKEKVETRTDSESEEEKVTVKITNPRKKVEQKGKVEENKKTKVRSITPDRLSETNPFRQIEQKGKVEANKKTKVRPITPDRLSETNPFRDIELWETTTTFPKMKEEDETSIIKRKSVTSHQSHFDKMYRYLRNAGVPKEEAKHGTLMASEPLNDEALCDSEVEPEETILAKDCRVKSNQSYYNNQKLLQNQQQMTISLLAQVPAFNGMGSTKFEDWIKYFERVIDTSEFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9HYW5</accession>
    <name>E9HYW5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_219748</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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        <property type="protein sequence ID" value="EFX60825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60825">
        <property type="protein sequence ID" value="EFX60825"/>
        <property type="gene ID" value="DAPPUDRAFT_341238"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_341238"/>
    <dbReference type="eggNOG" id="ENOG502RVKR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2560613_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="82" mass="8648" checksum="A0A72420CE7762AF" modified="2011-04-05" version="1">MDIKEEAVGLGSVDIVDNTLKENNNIDSSPATEPKYKLDIKEEAVGLGIVDVDDNTLKETTSTALTVVDPSSPAVQSGSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9I6J9</accession>
    <name>E9I6J9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_344096</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL736531">
        <property type="protein sequence ID" value="EFX60381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60381">
        <property type="protein sequence ID" value="EFX60381"/>
        <property type="gene ID" value="DAPPUDRAFT_344096"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_344096"/>
    <dbReference type="HOGENOM" id="CLU_098073_0_0_1"/>
    <dbReference type="InParanoid" id="E9I6J9"/>
    <dbReference type="OrthoDB" id="1375356at2759"/>
    <dbReference type="PhylomeDB" id="E9I6J9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX60381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="248" mass="29073" checksum="6B9A4EF9B1F109C3" modified="2011-04-05" version="1">MDSLAQRFLSSSSTSRSSGGEWTRKLYLYPDVHNLTKDIREHVITNSELLRFGRNKTTKEEKLEKLLGEDEEIELVRVYSNPLNSAQMTKVALHHAFVLFKIRQKTKPETWWSIEKNTKSITIQISKNGREIVRDCYKRERRPVGPTTPNTRDRDLPANENATVYNLIQHIYDGNYLNDPYNLKNSNCQHFADRIFEFLAIPLADRCRRMLTRSVFILIITCSVLLVFYALLQILSTMWTRFQEPDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9I799</accession>
    <name>E9I799_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_125401</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL737074">
        <property type="protein sequence ID" value="EFX60131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60131">
        <property type="protein sequence ID" value="EFX60131"/>
        <property type="gene ID" value="DAPPUDRAFT_125401"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_125401"/>
    <dbReference type="HOGENOM" id="CLU_1035336_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="269" mass="28677" checksum="78635F6D3A7235C0" modified="2011-04-05" version="1">MSSLWPEVRHKINPMQVVDDYADVYGVNPETIHDDETAGAMAAQEQQQMAAQQVAAAVPDMAKAAQAVGNTNPDQLQSGFDMATRVSAGFQFTEDDATGDPTGLRRPSDGKTFALFLTTEQVDQLLAPGLLAGVVYDASNRAIAWAIDGTNYTASYSNAEIVFDTTAARLATIDYWAAFTHPSNQRDIDRVYAFRDLDRNTATDAQVTQAYGGPGWVPVPMCAECGGRDDGVIVFGANVAALCPTCVSAAAELIAPAKKPGLFSRFRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9I7H7</accession>
    <name>E9I7H7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_125672</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL737228">
        <property type="protein sequence ID" value="EFX60053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60053">
        <property type="protein sequence ID" value="EFX60053"/>
        <property type="gene ID" value="DAPPUDRAFT_125672"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_125672"/>
    <dbReference type="HOGENOM" id="CLU_923079_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX60053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="302" mass="30497" checksum="99EC97CB518209F3" modified="2011-04-05" version="1" fragment="single">AVAPQGSADEAVAAAQHAAVLHRHGAGAAAADIQVGVERQLGRRTVNQDRALAAVIEADKGLIGGGLACRDVQDAAAAAAHVETAAQVELGIRGAQVHRAVASVQLAEEQFRSGQLAVGADVQRALAGRADLGAGIFVGDQIDAVLEGQRVVQLAKVPELQTAGATIPGLVRPGFETEVEGLQLAAVVLDIAFEGERAEGARIEGEGARIAAKGEVDLDQVAAGQAADRPVGVVVIEEQLGPGGKGADGPRLAVDDAGNAPVHSGGPLPVDLAGPGVGGRRGRRQVTDAQSRSQRDAERQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9FQW2</accession>
    <name>E9FQW2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_309814</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX90301">
        <property type="protein sequence ID" value="EFX90301"/>
        <property type="gene ID" value="DAPPUDRAFT_309814"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309814"/>
    <dbReference type="HOGENOM" id="CLU_2225803_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX90301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="106" mass="12290" checksum="C3DEE36ED60E8BB6" modified="2011-04-05" version="1">MKLNGFIEDFSWNSKCHCNQWLRITSKHKDGDNKHNEGMWDQHLSLFLDGLLLRAIIPTSNYSLTLKNNHTITLTYTGTPIWDTDMNDNSSKEGEIQKANRSEHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRZ4</accession>
    <name>E9FRZ4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_309603</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX89936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C01.067"/>
    <dbReference type="EnsemblMetazoa" id="EFX89936">
        <property type="protein sequence ID" value="EFX89936"/>
        <property type="gene ID" value="DAPPUDRAFT_309603"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309603"/>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012184_11_0_1"/>
    <dbReference type="InParanoid" id="E9FRZ4"/>
    <dbReference type="OMA" id="KAFHHFK"/>
    <dbReference type="OrthoDB" id="1275401at2759"/>
    <dbReference type="PhylomeDB" id="E9FRZ4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018551868" evidence="6">
        <location>
            <begin position="23"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor_I29" evidence="8">
        <location>
            <begin position="282"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="7">
        <location>
            <begin position="366"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX89936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="584" mass="65561" checksum="AF8414AE9F61A285" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSC1</accession>
    <name>E9FSC1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_303582</name>
        <name evidence="3" type="ORF">DAPPUDRAFT_94544</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732740">
        <property type="protein sequence ID" value="EFX65541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65541">
        <property type="protein sequence ID" value="EFX65541"/>
        <property type="gene ID" value="DAPPUDRAFT_303582"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89183">
        <property type="protein sequence ID" value="EFX89183"/>
        <property type="gene ID" value="DAPPUDRAFT_94544"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303582"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_94544"/>
    <dbReference type="HOGENOM" id="CLU_940927_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX89183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="296" mass="33218" checksum="BDC7718C03729D53" modified="2011-04-05" version="1">MSAKKVNTQQFPEPKVLREKNNFQNKSKQSKRSGAGGELRNPSPAPISPQVATQTHSADPVSPSTKDEIEKQSTAVWHGPNCPSCEDLASITKENMGRLQHHFKFGSIYSIYFRIMMALHTIIIASPNSNDYKKDSNIFYPKQAKDLCELSASSEIISKNQPELFKEAAKLSNELLGPTKSDKFNCDRYEDYLELLLKISQTIGADKDLVGDIDTYLKPFRPEPIGDGSIAMGESELGNDPRKWQETFLDLKHSPEDENFGYELKKIAEPRRNKASFELIPTGYVFKCHGLSTNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9FU35</accession>
    <name>E9FU35_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_190896</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Wang M."/>
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    <sequence length="437" mass="49066" checksum="CD8F348080B95D3C" modified="2011-04-05" version="1">MVFFVVKIVEDDEIVVVPVHWFMFSENKCALPIKDAAQRAEREEVFNLRWPRYDAKVISSHDSYEDAVRRSESILNGSADTEVSDSVKTFQAQEKSKTRPRRATVKKAIVENPLDTGSDEDRLNHIADKHAVEDLAAMWLNPSPSTSKRAVQPVSFTNPVSSTENRVDPVEGYRGNSPQSDESIIRSSAVLPEPPTEEVSLDASSGKRKERGGKNDSTDIEEDSPEEKEDSCIEPSSKSRKVIDDNTFKTKVLTKLSNLFALTKGMGRDIQDIKSDNRDMRSQFKKNFQAKVDVSDKSHPVFTLSQKYSFPLKNLEDFKKFDDSLVDSVVSTDQIRVIRSLGGNDLGAVLRTAWRYFMTDELLSQLTWKGQHKSTSKKPKGMPGLESYRLPSVIYNAIKEEGGLYSNVSLTELNKLSAEFVTKAGTRLASKKKKVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9FWV7</accession>
    <name>E9FWV7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_42080</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the bestrophin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88369">
        <property type="protein sequence ID" value="EFX88369"/>
        <property type="gene ID" value="DAPPUDRAFT_42080"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_42080"/>
    <dbReference type="eggNOG" id="KOG3547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018069_0_1_1"/>
    <dbReference type="InParanoid" id="E9FWV7"/>
    <dbReference type="OMA" id="ENMDIAF"/>
    <dbReference type="OrthoDB" id="279144at2759"/>
    <dbReference type="PhylomeDB" id="E9FWV7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin/UPF0187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="PTHR10736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX88369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="425" mass="49347" checksum="D5A041C99384D81C" modified="2011-04-05" version="1">MTVTYTAQVATCTGLGCFWKLLFCWKGSIYKLLWPNLVVYVLLYYVLYFVYLFALDEAGQLRFEKISKHCLEYSDLIPLSFVLGFYVNLVVKRWWEMFQSIPGTDTLAIFVANSIPGQDDRCRLMRRTIMRYVNLSYAMILSMVSTRVKKRFPTLDHLVEAGVLLPNEKKIFDDLNARSRYSKFWMPLVWAGSIITRARREGRIRDDFAVKTMLDELCSFRAKCGALNGYDWVPVPLVYTQVVTLAVYTFFMATLMGRQLVGEQKDLYVPVFAFLQFFFYMGWLKVAESLVNPFGEDDDDFETNWLIDRNLQVSYLIVDEMHNEHPELLRDQYWDEITPQELPYTVASQAFRTSPHMGSTAQLTMTSYEKELFQSGSQLHRLEEESDGDPSTESEGIIPDDGGESGYEELLCCSRLSYLNIYLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9FY03</accession>
    <name>E9FY03_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_305738</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX88199.1"/>
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    <dbReference type="EnsemblMetazoa" id="EFX88199">
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        <property type="gene ID" value="DAPPUDRAFT_305738"/>
    </dbReference>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2230"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2426"/>
            <end position="2443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2570"/>
            <end position="2592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="2601" mass="274954" checksum="6CA6CF11EAF916D9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9FY52</accession>
    <name>E9FY52_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA methyltransferase 5 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_207230</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="8">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="8"/>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87837"/>
    <dbReference type="EnsemblMetazoa" id="EFX87837">
        <property type="protein sequence ID" value="EFX87837"/>
        <property type="gene ID" value="DAPPUDRAFT_207230"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_207230"/>
    <dbReference type="eggNOG" id="KOG2078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022610_2_3_1"/>
    <dbReference type="InParanoid" id="E9FY52"/>
    <dbReference type="OMA" id="DMYKIVV"/>
    <dbReference type="OrthoDB" id="788980at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009019">
        <property type="term" value="F:tRNA (guanine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="10">
        <location>
            <begin position="130"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="8">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="8">
        <location>
            <begin position="285"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX87837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="424" mass="48692" checksum="E17C06E9B8EF4EF3" modified="2011-04-05" version="1">MDLSLPNVRGMTELDREKFSKEVNVPSVEILSQNIGKSMHVFKKYLLKMEKLKPVVEVDGTVERKKMLLDPLLFETVEKLSEEQQTKLSELDVNNDNFSRTCLHLQYENFRIDDIFKAVLPEGKEGCTSYSRIGHIIHLNLRDHLLPYKNLIGQVLIDKLIGVRTVVNKSSAIDSTYRNFQMEVLAGETDFITEVKENLCTFKFDFSQVYWNSRLCTEHERIIKLLPQNCVLFDVFAGVGPFSVPAAKIRKCQVFANDLNPSSYHWLKENVRINKVAKVETFNLDGRQFIREQLSSFLLRKPTEPIHVTMNLPALAVEFLDAFIGLLAGIELDSLPDITVHVYSFCEESSAFSEMRTKVESSLNHSIEDGQIVELVDVRDVSPKKHMLRLSFRIPIEILAKSRPEVEEETSEPKRLKLDLESQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E9G0L2</accession>
    <name>E9G0L2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_307064</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87381"/>
    <dbReference type="EnsemblMetazoa" id="EFX87381">
        <property type="protein sequence ID" value="EFX87381"/>
        <property type="gene ID" value="DAPPUDRAFT_307064"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307064"/>
    <dbReference type="eggNOG" id="KOG0721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014210_1_0_1"/>
    <dbReference type="InParanoid" id="E9G0L2"/>
    <dbReference type="OMA" id="RAILHAH"/>
    <dbReference type="OrthoDB" id="686427at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
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                <person name="Thomas W.K."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dusheyko S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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    </evidence>
    <sequence length="96" mass="10902" checksum="EFBD845D70AE7314" modified="2011-04-05" version="1">MARDLEVSSRSSSSASHLTDRLGSVYSDQLRPLDPRALDPRAYYLRMPESHPPPVNNARDSNSVRITTPYRQDPVKRNTSAPPSINRVRGLRRVQF</sequence>
</entry>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Dong Q."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX85279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="321" mass="36694" checksum="1804E6578E5E0EA6" modified="2011-04-05" version="1">MADMSAFVPKKMAEWERKVDHLIWQIEVASDEKWEELTKLQGLIVVDVYSEWCGPCTAMATHLKEIKLLLGDDFLHCALAKADCISQLEKFRGRSEPTWLFLAGGEPVVLIRGANAPLIRKTLFQELQTEKEVLEGTRQRVTISWDNALLTTAPDNWWELDGLTLQGSYPLIVDKLMEGLVERNLEIVATSAVQVDKKDCLILWFPTYVDYLSLSDWFEHKLKTLIAEVEPKKVIIKPARDEGELEEQIEGLNLEDLIGIPDDNSPVIEIDPEVSDYEPIQYRLISDPDEKDSLIKRISERPTENVESKSVEVDEDEEIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9G503</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="common">Water flea</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX85629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="205" mass="22503" checksum="82D2816F8997306F" modified="2011-04-05" version="1">MPRYFSSVALFFAFNNSSLCCKLTKCCCGCSLQTGSKVIGVLSLLAGVTGFLLAVISVSSLNLQNGIHEQLASSIGIILGALVVIAMSISALVAAWKNCKPMLLVPWLVLNALSLPILIASVIYYKDRWLTVKEGGTCSGTGFIAWGLIVGGIWFYFWLVINSYYHQLKAKKKPPPLPDERTVMRFRECENSVIRVDQMLTQMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6R9</accession>
    <name>E9G6R9_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_314319</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX85142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85142">
        <property type="protein sequence ID" value="EFX85142"/>
        <property type="gene ID" value="DAPPUDRAFT_314319"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_314319"/>
    <dbReference type="HOGENOM" id="CLU_2471311_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX85142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="88" mass="10032" checksum="A68060B7D2C01918" modified="2011-04-05" version="1">MNFILRKESAMMTTTEPLLLRSEVKKEESDLHHHHHHHHMCGMEDCSPADSSLYSPTTTGLQLEVIYIHCVPCPIRLFTFSTPESIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7M1</accession>
    <name>E9G7M1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_223002</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84493">
        <property type="protein sequence ID" value="EFX84493"/>
        <property type="gene ID" value="DAPPUDRAFT_223002"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_223002"/>
    <dbReference type="eggNOG" id="ENOG502S5QE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137568_0_0_1"/>
    <dbReference type="InParanoid" id="E9G7M1"/>
    <dbReference type="OMA" id="TFRFSCE"/>
    <dbReference type="OrthoDB" id="1549742at2759"/>
    <dbReference type="PhylomeDB" id="E9G7M1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="SSF57625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237232" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="53"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX84493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="141" mass="15593" checksum="4ABFBB32F7EA8AD3" modified="2011-04-05" version="1">MNSLAVICGLALFAVVLASPFGDHRVRRQAETIEEKLGLPSNATAIRNNIVDTFSCDGKIYGYYADVDNECQLFHICYPVELADGTKQTFKWSFICPEETIFNQESMTCTFPTDAIPCSEAASFYNLNQNFGVIPSTTVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8Z0</accession>
    <name>E9G8Z0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_315173</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84189">
        <property type="protein sequence ID" value="EFX84189"/>
        <property type="gene ID" value="DAPPUDRAFT_315173"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315173"/>
    <dbReference type="eggNOG" id="ENOG502SDE8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2190652_0_0_1"/>
    <dbReference type="InParanoid" id="E9G8Z0"/>
    <dbReference type="OrthoDB" id="1541698at2759"/>
    <dbReference type="PhylomeDB" id="E9G8Z0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240982" evidence="2">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX84189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="111" mass="11744" checksum="B7EB67B00B9089E2" modified="2011-04-05" version="1">MASKLVLVTLFLAAVVAAASARPRFLAIPIEDIQFLRGPAPYPGFAPQQPALRVRRASPIDEERQGAASQPRASSSYGGNDYVDYGAYTGGNGAFGWYSDHPVGNHGSGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8Z2</accession>
    <name>E9G8Z2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_315175</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="protein sequence ID" value="EFX84060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX84060">
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        <property type="gene ID" value="DAPPUDRAFT_315175"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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            <begin position="23"/>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_075165_4_0_1"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="165" mass="18525" checksum="E4275AFD54B71C3D" modified="2011-04-05" version="1">MRIQLFTWLVMAAVLLAVSSAGNIPSALTYKHNEHAAKPSNFKFPSDDVYSTGYRRILHPDGRIQIVSYVTDAKHESERKYQENRPVASYPAPAYRAPPTTPRPYVTTTSAAPFYPSPISHVVVSPPYGQTVDFSSPYDDPTYVTSNVDLSTLFRETASRKFLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="EFX82449.1"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX82449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="339" mass="40288" checksum="8A288DA55BFDFC34" modified="2011-04-05" version="1">MFKTIFRFIPVRRYSNSSFIAGVIFGCCLISFVNHEFHRPLFLSLLSGNDGNSNGHYETFFKNFDNETGADRFIVPNIIHFIRFDNFPLGFVDYVVLKAAMRNHKPDKFFFHTDVKNATCEGKYWDLVKKDRDLWSRIEVKYLEAPTEIFGQQLSEDFRFYHGSDIARIRVLMQYGGIYLDNDCFVIHSLDKYRKFECVVNWDEGQFLGNQVFIAHKNSRFLALYLESYKDNYYPDRWYYNGGERPTTEILFHHPHLIHRVKGNFGADTGVGSSLFTDPNYDWRRFDIIHMLMGHRYYMDPHFNETEEFDEDNIRTYRYTFGTMARQVLDLEPDFSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEG1</accession>
    <name>E9GEG1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX82318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX82318"/>
        <property type="gene ID" value="DAPPUDRAFT_302573"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240273" evidence="1">
        <location>
            <begin position="27"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX82318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="212" mass="23789" checksum="1B500131137ED9AB" modified="2011-04-05" version="1">MTIFSEFHFGLLVLLVFSNNSYSIDGLTIENPVQLSRDDYCPPQYKLCSDETATTPTGKITLSNLAVGNSPKECYFDIYAPVGQYVQMTCSDVFSSVWTNYFSLRGTVETFASPPVLKRIYTSYDNRMGISSRVTSGDRVNCNWEMMTVPSGTTDFKFCIHGRTKASSGTIRPVDMSTGETRWCRFFIEAPSNQRVQLSCSTMKLNNSPRVT</sequence>
</entry>
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        <name evidence="2" type="ORF">DAPPUDRAFT_242162</name>
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        </lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX81577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_242162"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG3671">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="PhylomeDB" id="E9GG11"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WASP"/>
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        <property type="entry name" value="WASPfam_EVH1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="139"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="161" mass="18461" checksum="38E04E253E49B2E0" modified="2011-04-05" version="1">MGASKTFKSRRNCPSRLLSKEENTQLNEIIGAQCKSAATTVVQLFLPEPPEYTQWTKEDCGILCLIEDSNCNFWLKIFCLVRRQVIWQQKLHENVVYHAPAPYFHTVSSSNNTQIGLNFADEAEASIFLRTVRAYLLKNKGIKDNIKTISHDPEMTFKSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
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    <protein>
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            <fullName evidence="3">BPTI/Kunitz inhibitor domain-containing protein</fullName>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Manak J.R."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX81062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="E9GHH3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00014">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX81062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="51" mass="5684" checksum="4C485B4417AFF3C3" modified="2011-04-05" version="1" fragment="single">CMQPKAVGSCRGSIPSYFFDMQTGQCTPFNYGGCGGNDNRFKSYHECDFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_196379</name>
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    <organism evidence="6">
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        <lineage>
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        </lineage>
    </organism>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDS22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732557">
        <property type="protein sequence ID" value="EFX78432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78432"/>
    <dbReference type="EnsemblMetazoa" id="EFX78432">
        <property type="protein sequence ID" value="EFX78432"/>
        <property type="gene ID" value="DAPPUDRAFT_213002"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_213002"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044236_1_0_1"/>
    <dbReference type="InParanoid" id="E9GPR7"/>
    <dbReference type="OMA" id="YDNLIAH"/>
    <dbReference type="OrthoDB" id="968788at2759"/>
    <dbReference type="PhylomeDB" id="E9GPR7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRcap" evidence="6">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX78432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="316" mass="36241" checksum="0CB8F2ADFF161E1C" modified="2011-04-05" version="1">MEAFGEPNDPSQNVAEESVDKEIETNELIVLDPDATEVDFNHGRIAKIENLECLTQVEGLYLRWNLIKKIENIGMLSTLRELELYDNQITEIENLGSLVNLELLDLSFNRIKTIQGLDTLVNLKKLFLVSNRIEKIENLSKLKELQMLELGDNRIRVIENLDELTNLESLFLGKNKITQLNNLQSLSKLKLLSIQSNRIVTIANIDKLVNLEELYLSHNGIQVIENLENNTKLQTLDLAGNRIKLIQGLDTLGNLEEFWFNDNLVEDWNQLDGLRGATTLLTVYFERNPIQKDVNYRRKIKMALPSLTQIDAALCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQ74</accession>
    <name>E9GQ74_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_198026</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732558">
        <property type="protein sequence ID" value="EFX78082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78082"/>
    <dbReference type="EnsemblMetazoa" id="EFX78082">
        <property type="protein sequence ID" value="EFX78082"/>
        <property type="gene ID" value="DAPPUDRAFT_198026"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_198026"/>
    <dbReference type="eggNOG" id="ENOG502QRDQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033265_0_0_1"/>
    <dbReference type="InParanoid" id="E9GQ74"/>
    <dbReference type="OMA" id="WFETRME"/>
    <dbReference type="OrthoDB" id="1305843at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010216">
        <property type="term" value="P:maintenance of DNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="PTHR14140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="4">
        <location>
            <begin position="147"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX78082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="355" mass="39957" checksum="B7ACCE6FEF490D6E" modified="2011-04-05" version="1">MAPLKESKMSEYELQRVKNMEENRRILESIRQEQIYKFEALQPAVVKKKEKKPAEARPKKKPRIETEGQPAGAEVDDGRRKSSRISGKAPDRSKGIGDDDSGDDDYEADEYDDDDSEEEDGEGRKRKRVRGPQQKIIVPKNRPNFYGAVPGVEIGRIWEMRMHASADGVMRPPVAGIHGGPEGAYSIALSGGYEDDMDLGDCFTYTGEGGRALKGTKANPKNLRTAPQSKDQTLTKGNLALSLNIETRKPVRVIRGYKANTEFTPEYGYRYDGLYTVEKYWLCVGKSGFKVFKFALRRCPNQAPPPWVTDKRKKTEKKEESNQSEDGKEKQEDESVDKENRDKSLNSPPPASSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQZ7</accession>
    <name>E9GQZ7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_305262</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732558">
        <property type="protein sequence ID" value="EFX78205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78205">
        <property type="protein sequence ID" value="EFX78205"/>
        <property type="gene ID" value="DAPPUDRAFT_305262"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305262"/>
    <dbReference type="eggNOG" id="ENOG502SB23">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098073_0_0_1"/>
    <dbReference type="InParanoid" id="E9GQZ7"/>
    <dbReference type="OrthoDB" id="1375356at2759"/>
    <dbReference type="PhylomeDB" id="E9GQZ7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX78205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="198" mass="23311" checksum="81128FA13ECC8A57" modified="2011-04-05" version="1">MGSWISYTSTNYGIPLYYFDPDVELTPERPDYCSTKWELKEKIENLPDSSEKINEVRYYTHPLNWWQMSKYVLHHAFIVLETESWWWSIEKDEGGITIQRSKHLENVLDQCRRHGRITGLATWINLGVTCEKKGPSHASVIDVVNRMWREECLHSDYHFLQNNCKHFANTIYDNFVLMSNSNDVPIIEKVELPIPAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9GRV1</accession>
    <name>E9GRV1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_105806</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732560">
        <property type="protein sequence ID" value="EFX77838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77838"/>
    <dbReference type="EnsemblMetazoa" id="EFX77838">
        <property type="protein sequence ID" value="EFX77838"/>
        <property type="gene ID" value="DAPPUDRAFT_105806"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_105806"/>
    <dbReference type="eggNOG" id="ENOG502QS2U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046369_0_1_1"/>
    <dbReference type="InParanoid" id="E9GRV1"/>
    <dbReference type="OrthoDB" id="1380644at2759"/>
    <dbReference type="PhylomeDB" id="E9GRV1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX77838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="330" mass="37344" checksum="AC63534907F0A4DE" modified="2011-04-05" version="1">MGNNISNVDSKPVVIILGGLLTSSSILAVWFFYDRINRATRFDNLKETNCNIEQLNSAIDILRKEIEELKAASSKVDLNNEKDEDCKSKKSFKVVRFKNTLSYMSSTSDVEYQSAWSDNEGSTEEFFDFPENDLGDQINITNISSEAIDLFDKVDSLLEGSSADHEVAFRLLTDHESEFDCNVEFLWRIAKSCRMAAQASPDPNRQKELSFKGLLSHWVPQVVTLAFQKKSAMVSSLSWIERKVAAALFKDIPSGSIEEALSHFLHSDKLRAKPSKTNSLYIAKCFIQLGKYDQAMHWINLALPISVMTTEDQSSHDELLILHSKYNSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTJ6</accession>
    <name>E9GTJ6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_321675</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732564">
        <property type="protein sequence ID" value="EFX77094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77094">
        <property type="protein sequence ID" value="EFX77094"/>
        <property type="gene ID" value="DAPPUDRAFT_321675"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_321675"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_12_2_1"/>
    <dbReference type="InParanoid" id="E9GTJ6"/>
    <dbReference type="OrthoDB" id="289441at2759"/>
    <dbReference type="PhylomeDB" id="E9GTJ6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015301">
        <property type="term" value="F:anion:anion antiporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="512"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="560"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX77094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="678" mass="74096" checksum="69027EF34CFEA7D0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9GU55</accession>
    <name>E9GU55_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_305976</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="114" mass="11697" checksum="7C338E62BBE2F1EA" modified="2011-04-05" version="1">MQNGASKSESTQETVYDVEFIIDKTFRIQGRKLADLEVNPPIPTSIAPDHQESFDSEDEACSPLFHPPEANGSAEVSGAVEAAGLGDVAGLAGASGSADTSGTANSAGLDDMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9GXW9</accession>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
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        <text evidence="2 6">Belongs to the XK family.</text>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="42"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        <location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX75740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="334" mass="38737" checksum="B31FD312DAD1BDAF" modified="2011-04-05" version="1">MGAIKRKKDPSTQERVNPQPPSQVVEFAQKCKENIEISSVNWCTLAFLVTPIVVITFKSFSFYNNGFKNTDTLFDPRHSLPKEEYTFSNWVKWVLGPVGLCLIPRYWDIIKYADKAKQAKIKNGEKQYMYFVAMIWEDAELLQLSQFDCFMESAPQLLLNLYMLVKGESDLGVYTAIGFLFPIISLSWAIVSYDKKCCLIKGIKPDEGNRQGRMSILNDDAIDCYKTFNLKTSAILFSAHFFGIVARFIALSLFTSVFGWIIWPACLAHLIPIFVWHRNENYSFMDSLRLSFLHVFAYLYPAERESDQKKHPRFSPVMYQTVRLTIFESQTLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9GY64</accession>
    <name>E9GY64_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_107767</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732574">
        <property type="protein sequence ID" value="EFX75546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75546"/>
    <dbReference type="EnsemblMetazoa" id="EFX75546">
        <property type="protein sequence ID" value="EFX75546"/>
        <property type="gene ID" value="DAPPUDRAFT_107767"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_107767"/>
    <dbReference type="eggNOG" id="KOG4205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_3_4_1"/>
    <dbReference type="InParanoid" id="E9GY64"/>
    <dbReference type="OMA" id="PQFGAAY"/>
    <dbReference type="OrthoDB" id="1565323at2759"/>
    <dbReference type="PhylomeDB" id="E9GY64"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037366">
        <property type="entry name" value="BOULE/DAZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176">
        <property type="entry name" value="PTHR11176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX75546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="348" mass="37531" checksum="447E712C0F759398" modified="2011-04-05" version="1">MDSNSNSSAGRGMKTDVGMSGLALDQSSSSGRSTPTDLPHNKLFVGGLSWQTSADKLGEYFGQYGTIIDVQVLKDPLTQEDRPKTRDAQEQWQSDVFIQDEEGLRRWCQSGHVSRRSRGLFQSIWTRRGGRYADGPADETSPRIRIRHIRERGVVDRICEIHYHMIKDKKVECKKAQPKEAILASNTSALLAAKHSVLLNGFGVAGLALEVAHVQQSSVIQVAALHFLATQAAQVQAAVVAHQQQAALAQSAVASAGYGKLLSSYPPLSSYRYSPYSLPGAAQGNVQAAAAAAAMAAASSGHHHHYHAMSTASTATQQAAAYQGYNLANVDMSSFQGIDWNQIYGMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GY83</accession>
    <name>E9GY83_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_250275</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732574">
        <property type="protein sequence ID" value="EFX75608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75608">
        <property type="protein sequence ID" value="EFX75608"/>
        <property type="gene ID" value="DAPPUDRAFT_250275"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_250275"/>
    <dbReference type="HOGENOM" id="CLU_2374913_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GY83"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="95" mass="10994" checksum="141FF15BBE9352EB" modified="2011-04-05" version="1">MATPADDNDSRTSEVEEVSDTVKVLKETLEVMKKEKKGFYAPKGSFPIKESVKKAIMDKYPHPEQAVYKLLEKLHNFDFMEIREKTEKEAKREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYB6</accession>
    <name>E9GYB6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_250325</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732574">
        <property type="protein sequence ID" value="EFX75592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75592">
        <property type="protein sequence ID" value="EFX75592"/>
        <property type="gene ID" value="DAPPUDRAFT_250325"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_250325"/>
    <dbReference type="HOGENOM" id="CLU_1887839_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="135" mass="15272" checksum="9F0147EE1DF66A2F" modified="2011-04-05" version="1">MKAIRLREYWVKFQFLVPAFKLIIQTYPFSNTFMSASSLSSHRPPSTHLATWKCPILSASVSRHSSAANYIAFPGHLSSQELPQASRSCLCYGAQPEENEDRHEDLVQRRPGLHPEDDVGVREDPSPEKPTKYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYU0</accession>
    <name>E9GYU0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_250561</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732576">
        <property type="protein sequence ID" value="EFX75352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75352">
        <property type="protein sequence ID" value="EFX75352"/>
        <property type="gene ID" value="DAPPUDRAFT_250561"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_250561"/>
    <dbReference type="HOGENOM" id="CLU_2760387_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="70" mass="8151" checksum="07031DD6F93185C7" modified="2011-04-05" version="1">MDESKVSSVSFPVLLKHLLPSLLPKRRMTMIAEQFEEDDHPQVEKFKATRSNGNHYNSSRGFIYHFQKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZE7</accession>
    <name>E9GZE7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_14029</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732577">
        <property type="protein sequence ID" value="EFX75171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75171"/>
    <dbReference type="EnsemblMetazoa" id="EFX75171">
        <property type="protein sequence ID" value="EFX75171"/>
        <property type="gene ID" value="DAPPUDRAFT_14029"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_14029"/>
    <dbReference type="eggNOG" id="KOG2291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2694881_0_0_1"/>
    <dbReference type="InParanoid" id="E9GZE7"/>
    <dbReference type="OrthoDB" id="1294725at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="PTHR21049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX75171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="74" mass="8525" checksum="1BD6CBAE0DF23AD7" modified="2011-04-05" version="1" fragment="single">NDALVRIILPEGAFNIEIETPYAVTRLQDTLHFTYLDVKGRSVVENAAKNLVENHIQPFKYTFPRIVMLQEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZR6</accession>
    <name>E9GZR6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_108301</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732578">
        <property type="protein sequence ID" value="EFX75040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75040">
        <property type="protein sequence ID" value="EFX75040"/>
        <property type="gene ID" value="DAPPUDRAFT_108301"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_108301"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_321900_0_0_1"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
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        </location>
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        </location>
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            <begin position="712"/>
            <end position="726"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX75040.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="900" mass="100889" checksum="D5073BF312D970C2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="5">CULLIN_2 domain-containing protein</fullName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1 3 4">Belongs to the cullin family.</text>
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        <property type="gene ID" value="DAPPUDRAFT_307204"/>
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    </dbReference>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX74542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3052461_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="EFX74542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="54" mass="6200" checksum="F54236B1BCE5331A" modified="2011-04-05" version="1">MRLEFLWKDGDNVKRSRGLIPVQDFILNCAEVLAVTDSGGILMLFREIRVDDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E9H1J0</accession>
    <name>E9H1J0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
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    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_129179</name>
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    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family. USP14/UBP6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="GL732583">
        <property type="protein sequence ID" value="EFX74497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74497"/>
    <dbReference type="MEROPS" id="C19.015"/>
    <dbReference type="EnsemblMetazoa" id="EFX74497">
        <property type="protein sequence ID" value="EFX74497"/>
        <property type="gene ID" value="DAPPUDRAFT_129179"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_129179"/>
    <dbReference type="eggNOG" id="KOG1872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017549_2_1_1"/>
    <dbReference type="InParanoid" id="E9H1J0"/>
    <dbReference type="OMA" id="MCKGGIL"/>
    <dbReference type="OrthoDB" id="600543at2759"/>
    <dbReference type="PhylomeDB" id="E9H1J0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="PTHR43982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="106"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX74497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="485" mass="54455" checksum="97D4DD46B52A051C" modified="2011-04-05" version="1">MPIFKVKVKWGKEVFNDVEANTDEEPILFKAQLFALTGVQNERQKVMLKGATLKDADWGNIKLKDGAVVLLMGSKEEDVPNEPKQKPIFVEDMNEDELASALDFPSGLTNLGNTCYMNATIQCLKTVPELCDALKEFKGEVSLSGGMLAGSVTAALRDLYSAMDRGNGSSIPPFILLQVLHAAFPRFAEKSSHGGFQQQDANECWTEILRMLQQKLQARNGTNQSIIDQYFGGRFTCELKCTESEEEPTTVSEDNFLQLSCFISQEVKYMHSGLLSRLSEQITKQSPTLGRDAIYMKSSKISRLPAYLSIQFVRFFYKEKEAINAKILKDIKFQLSLDVFDLCSSELQQKLIPMRSKFKEYEDRKIEEVKVANKPGDSQVAKADVKTAPYWFEDDIGSNNSGYYQLQAVLTHKGRSSGSGHYVGWTRKPGTNQWLQLDDDKVTPISEEDVLKLSGGGDWHCAYVLLYGPRLLEIDEGTDKMDTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9H374</accession>
    <name>E9H374_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_252658</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732588">
        <property type="protein sequence ID" value="EFX73821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX73821"/>
    <dbReference type="EnsemblMetazoa" id="EFX73821">
        <property type="protein sequence ID" value="EFX73821"/>
        <property type="gene ID" value="DAPPUDRAFT_252658"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_252658"/>
    <dbReference type="eggNOG" id="KOG0303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2225863_0_0_1"/>
    <dbReference type="InParanoid" id="E9H374"/>
    <dbReference type="OMA" id="QFADGAN"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="PTHR10856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX73821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="106" mass="11827" checksum="035192F6D75A7E1A" modified="2011-04-05" version="1">MVLEIDKDKRIDSFDIHDFKQASITPDTHRTIGMIPKRGVDVNKNEITLFYRITNSNKCEVISAIVPRTSKGFLEDLYPNTLGLVPALSAEALFTGEDGDPCLDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9H4Y4</accession>
    <name>E9H4Y4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_253488</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732592">
        <property type="protein sequence ID" value="EFX73224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73224">
        <property type="protein sequence ID" value="EFX73224"/>
        <property type="gene ID" value="DAPPUDRAFT_253488"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_253488"/>
    <dbReference type="HOGENOM" id="CLU_2051964_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX73224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="120" mass="13232" checksum="1133C22DC562DB84" modified="2011-04-05" version="1">MNVSDESCEQVKRIREFLSTHPIGTSLCPPLHHIGILSSGGRTNTSVKTHPADTSLQANNIGLQHQQRQSRSKSTTRKLKSMNFRQNSPSTANLGDGTLVSVPVCRLFDGRFDGKFKLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5A9</accession>
    <name>E9H5A9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_110126</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX73099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73099">
        <property type="protein sequence ID" value="EFX73099"/>
        <property type="gene ID" value="DAPPUDRAFT_110126"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_110126"/>
    <dbReference type="HOGENOM" id="CLU_1612487_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX73099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="165" mass="18577" checksum="AA343C191B9C9304" modified="2011-04-05" version="1">MKSQKKTKLTSEKKTKMKNKKKTKMKSQKKTKDKTTTETQKTLSNLMRTNIDGTMVIEPTTEQDGTVVQRLSWKELAGSYNICFLPVNFLSIIIISIMRKLIAVQCGGVNAFLNTNCITPPTFVKYEVDIEEDENGAACLQIAIDAAEVLENNHYLECSGWSCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6L3</accession>
    <name>E9H6L3_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_58703</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732597">
        <property type="protein sequence ID" value="EFX72680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72680"/>
    <dbReference type="EnsemblMetazoa" id="EFX72680">
        <property type="protein sequence ID" value="EFX72680"/>
        <property type="gene ID" value="DAPPUDRAFT_58703"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_58703"/>
    <dbReference type="HOGENOM" id="CLU_143058_0_0_1"/>
    <dbReference type="InParanoid" id="E9H6L3"/>
    <dbReference type="OMA" id="RNINAPM"/>
    <dbReference type="OrthoDB" id="79003at2759"/>
    <dbReference type="PhylomeDB" id="E9H6L3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="115" mass="13850" checksum="99B5B8F1F2B74128" modified="2011-04-05" version="1" fragment="single">ERNWQRFSFILDQYQEQPHFIDSHLDGLLTKIINIIREEVLDYEVKHVAFRCLYFISKVRGYKVVARHLPHETADLEPLLHYLENQDPGVQLKWETHYGLLLWLSIVVKIPFHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9H7Q6</accession>
    <name>E9H7Q6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DAPPUDRAFT_110963</name>
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        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_110963"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_110963"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022350_0_0_1"/>
    <dbReference type="InParanoid" id="E9H7Q6"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
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        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX72222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="420" mass="47098" checksum="1D5FCE0734E59DEA" modified="2011-04-05" version="1">MPNTPTPSPGPPGQQGPPGQQGPPGQPGQDGQPGQDGQPGPPGNQGPPGPQGPPGPQGPIGQIGAGGIDPRYFRTFSAAMTTGMLNLAAVNYRKDIPEFSGDLDDNTTFESWLKKENRVGVEAGWTEDQKLKFFQSKLRRAAAAFNNSLGVNRHRIDELYKSAYGRAAAESQDAEVIQLRNAVKKEALLKGMRLTIRTSLWNSLKPTDTYEEVVEKAQVCEQVVDLRRLTEESEAHKKVEQQENEKNKNPELQQIMQAIANIQLSADSAGVAAGTVAHISEQKQEGEKQVRFSGRSRSYSPRYRERQNPEDTDGRTRHYPLGQRSQSDYDWRQNRQQRAQETQSQRSNPLNRAPDNWDNQRNGGFPGGLEDRTCFFCKNKGHIKRACRKYQRWRAENVRGTQAPRDPTRRPFNNYKNVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9H8N8</accession>
    <name>E9H8N8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="4">
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        <name type="common">Water flea</name>
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        <lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX71314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="466" mass="52480" checksum="9648BE9B0291A734" modified="2011-04-05" version="1">MSWYHRTSVLVIILTILPDHVMLSTKAESTEFNGLLNGKILRVAAVEISPFVEFVRDENGIVVDGKGFSFEILAALMETYNFSITIEVPKDKAYGALLANGTWNGMIGMILNNESDVGIGSFSVTHVRNRVVDFTVAYYEESSGILIPAPTLGKQTSAFVKPFHFRVWIILIAILGILPCIMWVQSEILAKAKMSMAARKREQRFMLVYGVLLTQCKSSPLSSGQRIPEKDHSLRFLAMVWFLCALVFIHAYIGTLVSFLSVPNIKPIIRSLEELPASGLGWIVWRGSDLESLFMEAKDGLNRIIGDKLRNNPEWLVDSFVEGEQAVVDGDFVYMNNQARIRYAIEQNFIQSGKQCHLSMAKETFDKVNQAFALPKGSPVGSLFNRKMLMMMETGLMEHWRMKHLSRNDHCSTSFSYGTVLRKLTLEDVKSAFLIWFVGLSLAFAVFVAENVVFLAGRKFRNSRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9HAP6</accession>
    <name>E9HAP6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="6">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_309154</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732612">
        <property type="protein sequence ID" value="EFX71229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71229"/>
    <dbReference type="EnsemblMetazoa" id="EFX71229">
        <property type="protein sequence ID" value="EFX71229"/>
        <property type="gene ID" value="DAPPUDRAFT_309154"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309154"/>
    <dbReference type="eggNOG" id="KOG3459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_2_1_1"/>
    <dbReference type="InParanoid" id="E9HAP6"/>
    <dbReference type="OMA" id="GPMSLIN"/>
    <dbReference type="OrthoDB" id="1581611at2759"/>
    <dbReference type="PhylomeDB" id="E9HAP6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="PTHR12777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="8">
        <location>
            <begin position="33"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX71229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="122" mass="13722" checksum="BAD1BC1C3C732753" modified="2011-04-05" version="1">MAAVANKPKSEMTPEELAKREEEEFNTGPLSVLTQSVKNNTQVLINCRNNKKLLGRVKAFDRHCNMVLENVKEMWTEVPRTGKGKKKSKPVNKDRFISKMFLRGDSVILVLRNPLAGTPGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9HAQ2</accession>
    <name>E9HAQ2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_112010</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732612">
        <property type="protein sequence ID" value="EFX71222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71222"/>
    <dbReference type="EnsemblMetazoa" id="EFX71222">
        <property type="protein sequence ID" value="EFX71222"/>
        <property type="gene ID" value="DAPPUDRAFT_112010"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_112010"/>
    <dbReference type="eggNOG" id="KOG1777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005078_1_0_1"/>
    <dbReference type="InParanoid" id="E9HAQ2"/>
    <dbReference type="OMA" id="LGYFEAN"/>
    <dbReference type="OrthoDB" id="355502at2759"/>
    <dbReference type="PhylomeDB" id="E9HAQ2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029799">
        <property type="entry name" value="FBX11/DRE-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990:SF20">
        <property type="entry name" value="PTHR22990:SF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="SSF81383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
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        <location>
            <begin position="144"/>
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        <location>
            <begin position="822"/>
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        <location>
            <begin position="822"/>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX71222.1"/>
        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="916" mass="101208" checksum="80CE5A62C42EBFE4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="30" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="80" mass="9296" checksum="6B587FB0FCB5854C" modified="2011-04-05" version="1">MADVKIEKTDSTTEKPKVDLGLLEEDDEFEEFPADDWTGKEEDADDVNVWEDNWDDDNVEDDFSQQLRAALEKQGIKMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCS7</accession>
    <name>E9HCS7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Alkaline phosphatase</fullName>
            <ecNumber evidence="4 8">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_228306</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="4 8"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX70464">
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        <property type="gene ID" value="DAPPUDRAFT_228306"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="PTHR11596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="485" mass="52296" checksum="38143B1C17F8471F" modified="2011-04-05" version="1">MLFYFIDAAYWNQLGQQLLLDELGKQRINSQAKNIIFFLGDGMSISTVTAARIYKGQKAGKTGEEEQLTFDRFPYTALSRTYCTDAQVADSACTATAYLTGVKTDTDTIGIDANVEFNNCTTQLDPALHVDSVMAWAQAANKATGIVTTTRITHATPAGTYAHVANRDWEDDYAQSFDGVDSAICDDIAEQLVLSSPGKNFKVILGGGRAYFTPRTMTDIETGAAGRRRDGQDLIGQWVADHPTGKYITSRDELVNLDVAGTESVMGLFSPAHMEYFLESSTANNPTLEEMTRTAIQMLQKDANGYVLLVEGGRIDQAHHDGRAKLALEEAFQFDLAVAAALNLTNPADTLIIVTADHSHTMTINGYPVRGNDILGLVGYLAADLKPYSTLSYANGPGSINGYGVGGSRVDLTDVDTTADSFLQPALVPLASESHGGDDVAIFALGPQAHLFQGVYEQNYIAHVMGYAACIGPGVKFCDVPRKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDT2</accession>
    <name>E9HDT2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_257544</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Shiga Y."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
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    </evidence>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Dusheyko S."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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            <begin position="97"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="120" mass="12883" checksum="A34A358EA419D331" modified="2011-04-05" version="1">MEDSSAGILMHCLVSAGNPLRVSVWWTCIVALKNAQGPGVDGRLQLFRASEGKSQRGRKESKAACAKRRGYYGFPCIVKESVSVLVVLLRIRWTHGGAGGCERSARGPGPMADEGPQVLE</sequence>
</entry>
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    <accession>E9HJD7</accession>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_150238_0_0_1"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="126" mass="14173" checksum="57532FCDE516C67E" modified="2011-04-05" version="1">MPSTSAASSVVQSTTRQGRNVEPAVTFPNNRLCVTNEKYPAKVTQSALQQQNRNVPNIATVTSVIRFYSLSSKVTFIHLVAQLTYKRQNQYHLSSLLSITSLFTTFFGKFPEDLMVDYNDAKNIHL</sequence>
</entry>
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    <accession>E9HKM4</accession>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_115220"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9HKM4"/>
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    <dbReference type="PhylomeDB" id="E9HKM4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="203" mass="22965" checksum="CBDC522DD928A77D" modified="2011-04-05" version="1">MADQEHGQHEDAGLLGRGVEQMEVPALIHVGNFKEKDPPIFRGLPNEDVMEWIHQFQRVSVFHQWGAQQQLRHIEFSLEGVAERWLSGLDPRPNTIGGLLGALQRAFRHHNYAMELESRLRSRKQMDRLNIDELFRRLQAHSQAVLIAERSTPVNNILPVPPLSEDIGEATSDGGVISNLELWCGCSFATNTLSCRLDLVTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
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                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_330838"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG1928">
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="113" mass="12985" checksum="9540EF8195044FEF" modified="2011-04-05" version="1">MSGRINTSLVTLKKLKEKYNNIHLISFNLDNYMAGSPLKYWYHCNGWRDGPFHVSHLSDGLRFLTLHKYGVYFFDLDVISVRPVTDLRNFVATESDDYLGSGVLHADFKNPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKS7</accession>
    <name>E9HKS7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_115258</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Manak J.R."/>
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                <person name="Skalitzky C."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
    <sequence length="123" mass="13360" checksum="95543AFDF6DA75B0" modified="2011-04-05" version="1">MPSEDIQDFTAYPVHHIDFPFPDQCLQPETDCAHTPKAVTLPNACYHHESTKALLSDASHLIKDTVICGPVATNAVVHTRAAISVFFPSTFAANWLLPCSAFSVVLDLTSPDIQFSAVSLFTS</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_261494"/>
    <dbReference type="HOGENOM" id="CLU_2500165_0_0_1"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="86" mass="9710" checksum="7309CD0C508AE9D3" modified="2011-04-05" version="1">MKAGIRTCSCLKFSFALKHRKVFLGGQISMINQLIQFMLNKISTKLYPNSCKGLSKNVFLGSQRPVVNLLIHLMFHTMLNNGKNPV</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
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        <location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="191" mass="21882" checksum="1E28ACE9EEEE2F2F" modified="2011-04-05" version="1">MRDGDLEVIRDLAALRQRPNLHGNFIRYFAMEEDRDFIYVITEWCICSVEDLHGNGCNEGTNWIGEEIFVEKIKKSLGPKQILWQATKGLEYLHHLKYVHRNLKPSNFLIAKISDMDQPDEYKVKLSDFSYSKKPKESPKDTGQLGSNGWIAPISETGTIKAPEDYVADDVFVLGSFFHYVLTNGLHPFGI</sequence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732683">
        <property type="protein sequence ID" value="EFX67235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX67235">
        <property type="protein sequence ID" value="EFX67235"/>
        <property type="gene ID" value="DAPPUDRAFT_261953"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_261953"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
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    </dbReference>
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        <property type="entry name" value="SSF48403"/>
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        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="330" mass="37504" checksum="21C4B2D5D5DF0E1F" modified="2011-04-05" version="1">MSLLGQILVEGNLTELEEAPNVVGSSAQTEEEAEIPIAYVRQEIVDLSESNDEEDEDEEADSDATEENPHLAAEEHPSEDSQDRAWPDSPPPPPPPYSPEATSSRRRRSPLDQRGELRSPSPPARRLPNPGRSSPATATLTSDDGDALAAWLDRHPEYVENRFRLKTPLLVAIKHDAYECFQILLQRNANLEEYNPKNETALLIAVRLNRTRMVDDLIALNANIMPEDRMARTVTEILISRDDVETLKFLHIQRGNLLDHDLHNKEFPLTLAISHQSRKCIDYILSLKPKAQSFLIRRKYNCPISAAIRRNDYKTMEQLVTLEEFPYIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9HMQ6</accession>
    <name>E9HMQ6_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_64242</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732689">
        <property type="protein sequence ID" value="EFX66965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66965">
        <property type="protein sequence ID" value="EFX66965"/>
        <property type="gene ID" value="DAPPUDRAFT_64242"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_64242"/>
    <dbReference type="eggNOG" id="ENOG502QU73">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="PhylomeDB" id="E9HMQ6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="106"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX66965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="164" mass="18287" checksum="EC159672DBF38AA3" modified="2011-04-05" version="1" fragment="single">IQAGEGAALLCDVDMENERLYSVKWYRGDEVESVEFFRFVPRETPQLIVYNLPGINVNKTLSDWQRVYLSRVSLASTGNYRCEVSAEGPSFSSVSGSGHMEVVVLPKKKPTITGGKNSYKAGDLVDVNCTSAASKPAANIRWYINDERKVCDVYAFYILRVDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNI9</accession>
    <name>E9HNI9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_64459</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732696">
        <property type="protein sequence ID" value="EFX66705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66705"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_64459"/>
    <dbReference type="eggNOG" id="KOG0244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_4_5_1"/>
    <dbReference type="InParanoid" id="E9HNI9"/>
    <dbReference type="OMA" id="GECTPIG"/>
    <dbReference type="OrthoDB" id="390391at2759"/>
    <dbReference type="PhylomeDB" id="E9HNI9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="PTHR24115"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
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            <begin position="1"/>
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    <sequence length="1477" mass="163655" checksum="EB255041E8ED048D" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9HQ71</accession>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Shapiro H."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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</entry>
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    <accession>E9HQG5</accession>
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            <fullName evidence="2 3">Ubiquitin-fold modifier 1</fullName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
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                <person name="Tang H."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">Ubiquitin-like modifier.</text>
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        <text evidence="1 3">Belongs to the UFM1 family.</text>
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="GO_Central"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX65997.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="87" mass="9440" checksum="AF83CF9F74E3B873" modified="2011-04-05" version="1">MSGKVTFKITLTSDPKLPFKVLSVPEATPFTAVLKFSAEEFKVDPATSAIITDDGIGINPQQTAGNVFLKHGSELRLIPRDRVGNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9HRW0</accession>
    <name>E9HRW0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">DAPPUDRAFT_93732</name>
    </gene>
    <organism evidence="4">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732741">
        <property type="protein sequence ID" value="EFX65527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX65527"/>
    <dbReference type="EnsemblMetazoa" id="EFX65527">
        <property type="protein sequence ID" value="EFX65527"/>
        <property type="gene ID" value="DAPPUDRAFT_93732"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_93732"/>
    <dbReference type="eggNOG" id="ENOG502QWMD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071682_0_0_1"/>
    <dbReference type="InParanoid" id="E9HRW0"/>
    <dbReference type="OMA" id="CPEPNGF"/>
    <dbReference type="OrthoDB" id="1157817at2759"/>
    <dbReference type="PhylomeDB" id="E9HRW0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="SSF57625"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003242083" evidence="1">
        <location>
            <begin position="18"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="157"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX65527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="258" mass="28209" checksum="606245FFECD66775" modified="2011-04-05" version="1">MAKFFLAFLFVVASVYGQQADSDCPEKNGVFADTVQCDRYYECENFVLSEKLCADGLVFADLGVNSGVGGRCDFPFNVDCKDRPELQPANATANCPRQNGYFAHSDPTVCDQFFFCSSGQANLITCPGGLVFNPNTGTCSWPGEANRAGCQSKDVVAFDCPARVLEADPVGPQFIDPLYADPTDCQYFYVCIGGKEPRRNGCTTGLVFNDLTKRCDRPRNVPDCVDWYKTSEGDLLEPDVLDEVAAPPPKRTNFAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9HSL6</accession>
    <name>E9HSL6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glucosylceramidase</fullName>
            <ecNumber evidence="2 5">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_333354</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="2 5"/>
    <dbReference type="EMBL" id="GL732754">
        <property type="protein sequence ID" value="EFX65267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX65267"/>
    <dbReference type="EnsemblMetazoa" id="EFX65267">
        <property type="protein sequence ID" value="EFX65267"/>
        <property type="gene ID" value="DAPPUDRAFT_333354"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_333354"/>
    <dbReference type="eggNOG" id="KOG2566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2294440_0_0_1"/>
    <dbReference type="InParanoid" id="E9HSL6"/>
    <dbReference type="OMA" id="IDIWGIT"/>
    <dbReference type="OrthoDB" id="644299at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="PTHR11069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="domain" description="Glyco_hydro_30" evidence="6">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX65267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="101" mass="11267" checksum="C17D619A3164C96B" modified="2011-04-05" version="1">MDGNIPDFPFNCMGCTAEQQSNFIGLNLGTTLETKGFASIKIMVMDDQRILLPKWTETVLAHLEAKKYVAGVAVHWYGDLLSPPIALTSFHEKFPNHFILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9HST5</accession>
    <name>E9HST5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_117480</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732757">
        <property type="protein sequence ID" value="EFX65196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65196">
        <property type="protein sequence ID" value="EFX65196"/>
        <property type="gene ID" value="DAPPUDRAFT_117480"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_117480"/>
    <dbReference type="HOGENOM" id="CLU_1455838_0_0_1"/>
    <dbReference type="InParanoid" id="E9HST5"/>
    <dbReference type="OrthoDB" id="1343623at2759"/>
    <dbReference type="PhylomeDB" id="E9HST5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="47"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="186" mass="21092" checksum="8D755B9A6ECA1A0B" modified="2011-04-05" version="1">MGKMASPAGQQCYNVPIGKFFWKILSRCFNFLRVKVSQQMKDVVPPGWLPLANQSGWMDKGFFLLVLKHLRSQIVGLPTKPVLVFVDGHSFHVGYSVVMYCKEQGIILQTLPPHTSHGSQTFYDPFRRYLKQGNDEFMRRNPGKAITIYAVPIISKLVIEKAFPEHNIKQGFSAIGIFPLNRVAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9HSV4</accession>
    <name>E9HSV4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_265095</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX65183.1"/>
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        <location>
            <begin position="121"/>
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            <begin position="386"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="418" mass="46809" checksum="B33149BEDC917AEB" modified="2011-04-05" version="1">MINTLIADNGSRRACRGLVDKLDSMFADTERLNLLAVMPNDAEEFGRQAAIQIALFTQIETAKEDVDGFIDSRADEASSIASFQPLSIRSEVLRNWTQTQQLRQQTSQALIDAKQKAKEAQRTAEKLQKESDDAKQKADEANKEVANLTGAIGKRKSAMVEIMKAAINDWRRKSLIEPRSQETEEEGEPDCWIDRYCSGLEDPTWFYSHKAPSLKSELPLAILKSRLSGEQLDIVQGLGGGEPAYKSALSRLKQAAGRRDVMRVAHLSELDRMDLGRDPTAFRRFAEKARTHFFDLTRMGETSSSDIIERLCRKLHPSDRLEWNFGRGTGLERRSLNEFGEWLCERASAYQNAYNIVAEKASGNGLLQLSPSGTAEVITRSSPACPECSGSSHQRREKVRPDFSYSPRSPLAPYCISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9HU24</accession>
    <name>E9HU24_DAPPU</name>
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    </protein>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Cladocera</taxon>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_265831"/>
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    <dbReference type="eggNOG" id="KOG2322">
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    <dbReference type="InParanoid" id="E9HU24"/>
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    <dbReference type="PhylomeDB" id="E9HU24"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="Bax_inhibitor_1-related"/>
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        <property type="entry name" value="PTHR23291"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Bax1-I"/>
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        </location>
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="296" mass="32126" checksum="9C1A13C019F26015" modified="2011-04-05" version="1">MATQPDHPTHPSQPGQPSYGWEPPPPYNPNPPPYELPSAAPEQPQNNPQSPRTTPEQPSATNNMYAGGADYESGGLIDEDAFSFSEKSIRMAFVRKVYAILMVQLAVTVGLISLFVYEPNVKSYSRQHPEMCWIALAVTISEDVLIAAGICTAVCLALTIFAMQTKWDFTACGGILFVCVIVLFIFGIVAICIPGKVIRLVYASLGALLFSVYLVFDTQMMLGGNHKYSISPEEYIFAALNLYLDIINIFLYILALVGGSLPYCIPLNSSLGSGGTRYGDLKGAKSALPTDVWPNG</sequence>
</entry>
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    <reference evidence="1 2" key="1">
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                <person name="Basu M.K."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Shaw J.R."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX64679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64679">
        <property type="protein sequence ID" value="EFX64679"/>
        <property type="gene ID" value="DAPPUDRAFT_333952"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_333952"/>
    <dbReference type="HOGENOM" id="CLU_2429292_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX64679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="91" mass="9924" checksum="CCC71954550D6DBA" modified="2011-04-05" version="1">MVRCYGNRCTPCTATVSPTEPPELIKVIDQPIQNDYIAFLLGDDEEQMSADHSVVTFLAFPTDSLQDAGPGSNGDSNVCVLLRLFTYLVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9HVQ3</accession>
    <name>E9HVQ3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
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    <organism evidence="3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX64178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX64178"/>
        <property type="gene ID" value="DAPPUDRAFT_334504"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG2744">
        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </feature>
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            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX64178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="244" mass="25813" checksum="D8499FC2186E165C" modified="2011-04-05" version="1">MQGDDPPFLSVGTEVSAKYKGAFCEAKVRKVVKSIKCKVMFKLGLGSAVVSDDQIKGLLRKEKSKGKGYGYGAPEPEYKQPKAEHPIKYVPLPHHDLPVLIYQSDSQPPIHVVHPPAGDYAPAPAPQYASSYEQPAPSYDAGSAYAASAPAPYTPPAPVYEQAAPAYDAPAPAYPQPQAYETAPAPTYDAAPAAPAYEAAPAPAYPQPSYEPAPAPAYPQPSYDAAPAPAYPQQQSLRSTTGCL</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX63351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX63351"/>
        <property type="gene ID" value="DAPPUDRAFT_119285"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1950966_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="129" mass="14375" checksum="9D1C4D6B1AA0CD18" modified="2011-04-05" version="1">MGLANPSNQERVFFRVADVCIALNFVLDPFIYVLLRGQCGRSCCCRACSPSRCCWRCCRKMNRQETSFASQLAKDDDAKLAVGDLAFGMQTQETTAVPDRDYVPLKTLLADNENGLIMPAVHNSKEHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
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    <name>E9HYT5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX63095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63095">
        <property type="protein sequence ID" value="EFX63095"/>
        <property type="gene ID" value="DAPPUDRAFT_335947"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_335947"/>
    <dbReference type="HOGENOM" id="CLU_060623_2_0_1"/>
    <dbReference type="OrthoDB" id="279711at2759"/>
    <dbReference type="PhylomeDB" id="E9HYT5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="425" mass="47492" checksum="E96EEB0EE837BDCB" modified="2011-04-05" version="1">MGYCFINLIVLPLNVISTKKAAAAAVLKRQQLKEAKEREAGNKEPSIDTDTGHEAQNNVEESVASEEPVEEPGQELAPEREPVLDQGPADEEEPIAEIEKETANEEPPVKAKPAFNLRNVTVRLDRLALNPDGSTKAKKKKAQDADLKGGSSPPEKRRRMTRSTTKVGCSSDGQVTDDEVTRYFARKKIGLTNAKLRHRGPRISKGHPSMAPKKVNSDATMKNQKGKTFLKDKRYLSLLEFKRSVTTSLLFYGLNAEKARKEDAPEARLMKEIPLSAEPGAKRRKDRLSVPDEIRFSQVGIHHPIFVENRGRCEWCQATSERRPNGHTKESRPFSQCSMCKIFLCLSKKRNCFLEFHDDRILDPTKAAAETVLAVDPEEEIAVQTVETDPLGIYPSSDSSDDSDFDVLNNDVNDGVLLDEDEWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZH3</accession>
    <name>E9HZH3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_269577</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Zdobnov E.M."/>
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    </evidence>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Pritham E.J."/>
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                <person name="Basu M.K."/>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="144" mass="17537" checksum="F12B50ABABC31AA9" modified="2011-04-05" version="1">MGDPSRDKGWAQEWAKEREKALRKPSKPKTLKLIYSRNYRRPASNSFYPDFSWAILWMSRWTVLFCSNTYFSKDVMRWMVDDASGHMRTRSNLRHQICDSFIRLRIQLKLRNENLVSMPKRSTFTKQFWKRKRTREKHLTDVPF</sequence>
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    <accession>E9I5I1</accession>
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        <submittedName>
            <fullName evidence="4">EOG090X03V0</fullName>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TCO</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL735662">
        <property type="protein sequence ID" value="EFX60749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="SVE84790.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
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    <dbReference type="MEROPS" id="S01.024"/>
    <dbReference type="EnsemblMetazoa" id="EFX60749">
        <property type="protein sequence ID" value="EFX60749"/>
        <property type="gene ID" value="DAPPUDRAFT_230054"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230054"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_0_4_1"/>
    <dbReference type="OMA" id="PKSMIRE"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
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        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
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        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
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        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="12"/>
            <end position="29"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX60749.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SVE84790.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="317" mass="33781" checksum="F4759C923DF91E17" modified="2011-04-05" version="1">MVRPGTAVATPPQQLPPQQATSSGPRPSVHRPLPNSKFVCGVKGNHRELRELSVIENDNATTTLSSGFRQARVVGGNDALPGEYCWQVALINSLNQYLCGGALIGTQWVLTAAHCVTNIVRSGDAIYVRVGDHDLTSRYGSPGAQTLRVATTYIHHNHNSQTLDNDIALLKLQGQAELKPGVCIICLPSRGSVPETGRRCTVTGYGYMGETGPIPLRVREADVPIVSEGECVRQINAVTEKIFIMPASSFCAGGEAGNDACQGDGGGPLVCEDEGYYELSGLVSWGFGCGRAQVPGVYVKVSSFISWINQIISVNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Bork P."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX60447.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <end position="291"/>
        </location>
    </feature>
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        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="EFX60447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="314" mass="35562" checksum="A1F118C2868A232A" modified="2011-04-05" version="1" fragment="single">MALDIKEHGEGHFLSGKIESVTVNGNHSAMELKFAWWWGNACFDNSDCLHEELKYQPLKTLSITGRICKAGTVFLRHFQTSDSQPVFYRISEAILLAGKTFLVMEDLETVSFSRDRFCFTVIALKTYFSPRMSRKVLVTFKSFTEPVHVKKIVLPIYNPSIPDPVVLKELLFKEMLADKSIFSLGGNLNTRVEEVLIMKFDEDFQLVVDVHSSEIFLDLDRNVLVKLKKTEVRDADSVGADSIIFETAVDEEVKAGSVKRKNDELSSSSDFSSETSNESEEGSRKSTDFLYSSSDSLNAQDLYNKKPRCMEKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9I6K4</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX60376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PhylomeDB" id="E9I6K4"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX60376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="322" mass="37165" checksum="C968321B091832FF" modified="2011-04-05" version="1">MGWMRSFREKISSNRLVSKSWSLPIHSQQTLRRQLNSEEPLLSEPTNQQVNSSADQIRSDQLDPRSYEERRNNWAEQFNHLRQTEEPESVVLQNDSDNHSNIPEPLIGDNTDVLSYNQLLEQARAILDSSETPETNTNLREDPTNLVDIDFSNEGVDRSYFCTQFLHTRITDVPVDDLIFELQYLRKLNQREDITNTEIESALRALLLTEPTIITPFELFSHCQLKTNYEPPTESEYESVVSEREDLIEQNSNLLPLSDQETELIPDDRLVTIPVSIPSSTDISLGYPGDGLTDELDVQWYVPWTSSDNPNVATYDIKMRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9I6V0</accession>
    <name>E9I6V0_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2">
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        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL736722">
        <property type="protein sequence ID" value="EFX60280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60280">
        <property type="protein sequence ID" value="EFX60280"/>
        <property type="gene ID" value="DAPPUDRAFT_344259"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_344259"/>
    <dbReference type="HOGENOM" id="CLU_2040374_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="121" mass="14288" checksum="325919C05853B0A5" modified="2011-04-05" version="1">MKKQVKELIQKQTNTRSMDTEVDYDDYYRKLMGLVRLEGDDPVWRKFASLATPSFESLNEAQLRMQAQQLWKSKLELLAHLEKVQIELKMAQESTELRVGLYLKDKEALEEELRQAKARLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRG3</accession>
    <name>E9FRG3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_310020</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90203"/>
    <dbReference type="EnsemblMetazoa" id="EFX90203">
        <property type="protein sequence ID" value="EFX90203"/>
        <property type="gene ID" value="DAPPUDRAFT_310020"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_310020"/>
    <dbReference type="eggNOG" id="KOG1036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038526_0_1_1"/>
    <dbReference type="InParanoid" id="E9FRG3"/>
    <dbReference type="OMA" id="WDPFNRK"/>
    <dbReference type="OrthoDB" id="1048963at2759"/>
    <dbReference type="PhylomeDB" id="E9FRG3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990298">
        <property type="term" value="C:bub1-bub3 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX90203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="327" mass="36504" checksum="174CDEC263CFEB69" modified="2011-04-05" version="1">MADSSEIKLKSTPGDGISAVRFCPNSTPYLIVSSWDGSVRLYDCFTNNQRLRYNHDRAVLDACFQDAIHSLSGGLDGVLKLCDLNSNSESILGIHQDSIRCVEYSTAVNQVFSGSWDASIKSWDPRSKACLGTHMQGDSVYTMALNEEKLVVGTAGRRTLVWDLRNMSTALQKRESSLKYQTRCIKCFPSRQGFVLSSIEGRVAVEYFDPSPEVQKKKYAFKCHRIKEGDIECCYSVNAISFHCGFNTFATGGSDGHVNIWDGFNKKRLCQYRRYPTSISSLSFSFDGSLLAIASSYMYEQGEPSSAGSPEDAIYIRKVQEHEVKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRW1</accession>
    <name>E9FRW1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_232076</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90413"/>
    <dbReference type="EnsemblMetazoa" id="EFX90413">
        <property type="protein sequence ID" value="EFX90413"/>
        <property type="gene ID" value="DAPPUDRAFT_232076"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_232076"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_3_1_1"/>
    <dbReference type="InParanoid" id="E9FRW1"/>
    <dbReference type="OMA" id="EESVNIW"/>
    <dbReference type="OrthoDB" id="1289629at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="SSF57625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="22"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="459"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
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                <person name="Thomas W.K."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88692"/>
    <dbReference type="EnsemblMetazoa" id="EFX88692">
        <property type="protein sequence ID" value="EFX88692"/>
        <property type="gene ID" value="DAPPUDRAFT_41785"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_41785"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="InParanoid" id="E9FUA4"/>
    <dbReference type="OMA" id="YGNIGTQ"/>
    <dbReference type="OrthoDB" id="911009at2759"/>
    <dbReference type="PhylomeDB" id="E9FUA4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="8"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="111"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX88692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="374" mass="40970" checksum="915E4A9FCBC18DF8" modified="2011-04-05" version="1">MTLDIQQVLISDPVDPVCSQILQNHGISVTYARQWTKERLLQEIQNYEVLIVRSETKVTDEVLAAATKLRLVGRAGTGLDNVDISAATRRGVLVMNTPGGNTMSAAEHTCAMIAALSRHIPQACAALKNGVWDRKTYMGNELHGKTLAILGLGRIGREVAIRMQAFGMKTIGYDPVISKESAAEFKVDKMELEEIWPLADYISVHTPYMPQTHHLINAEALKRCKSTVRIINIARGGIVDEAALLDALISDRCKGAALDVFVQEPPKEGTTTWQLIQHPRVVCTPHLGASTVEAQERVAREIAEQLIDLAEGRQAVGIANAPNLARSMVERNKPWMQLAQALGYLANSLAEGSLHRRPAEAETNVELICCGTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUR5</accession>
    <name>E9FUR5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_234170</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88877">
        <property type="protein sequence ID" value="EFX88877"/>
        <property type="gene ID" value="DAPPUDRAFT_234170"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_234170"/>
    <dbReference type="HOGENOM" id="CLU_2348774_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX88877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="97" mass="10586" checksum="6E3A466AFCDAD719" modified="2011-04-05" version="1">MSGYGTYRLSVELFDRLGQIPKNRSPSQYKCQPDQIPEAIYRGVSPCLLEITLSKMTATRSPARGSPGLLGSHLLNVKMSSAFKGIASNDVDSVRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9FVY6</accession>
    <name>E9FVY6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FSH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_220828</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88631"/>
    <dbReference type="ESTHER" id="dappu-e9fvy6">
        <property type="family name" value="FSH1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88631">
        <property type="protein sequence ID" value="EFX88631"/>
        <property type="gene ID" value="DAPPUDRAFT_220828"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_220828"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_2_3_1"/>
    <dbReference type="InParanoid" id="E9FVY6"/>
    <dbReference type="OMA" id="EEPTVCR"/>
    <dbReference type="OrthoDB" id="1190789at2759"/>
    <dbReference type="PhylomeDB" id="E9FVY6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032526">
        <property type="term" value="P:response to retinoic acid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FSH1" evidence="3">
        <location>
            <begin position="2"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX88631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="224" mass="25461" checksum="3BA417C4BE687532" modified="2011-04-05" version="1">MRKILCLHGYRQSAQVFKDKTGSLRKLLKKHAELVYISAPHLIPATSSPAISSETQDNENVEVKPDEKTEEQRGWYFSTEALTFNSHDVTEFSWGLQESIDVISKAFEELGPFDGILGFSQGAALGSVLCHLLEKGELTFSFRFAILVSGFRSRLSPHVHFYETKQNVPTLHIIGETDRIVEKEMSEELTTYFESPQVMHHAGGHYVPATSKEKESYWTFLEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9FWJ7</accession>
    <name>E9FWJ7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_305598</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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            <begin position="23"/>
            <end position="134"/>
        </location>
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    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX87912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="84" mass="9370" checksum="D70E9EE37DEDB344" modified="2011-04-05" version="1">MPYLIDHPYDKEKISVCFLEKSTQDSTDILEPMLIILHDGRGTSIMLHPNLPDVRSSSFTASVLLMLQNNFACFTGEAGSLQLL</sequence>
</entry>
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    <accession>E9FY62</accession>
    <name>E9FY62_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C3H1-type domain-containing protein</fullName>
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        <name evidence="3" type="ORF">DAPPUDRAFT_96547</name>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87481"/>
    <dbReference type="EnsemblMetazoa" id="EFX87481">
        <property type="protein sequence ID" value="EFX87481"/>
        <property type="gene ID" value="DAPPUDRAFT_96547"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_96547"/>
    <dbReference type="eggNOG" id="ENOG502QQIY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="41"/>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="182" mass="20736" checksum="346947412499DE68" modified="2011-04-05" version="1">MDPTSSRCRSSQKGNPVIICPFFLEDRCKFGHQCHNLHPIRRQLSKKNKPKINQEDDLDLAAACHENLNRKMRTASDVIHRIQWDPALNVADFRVIYLDRFTGLGCTTMAEFLEQNSDDPTIPQHRIQQICYCPFTSSDSRCGWVVWEKQSRTDYVFGSGGGGATIKLLDLIRHASKTSQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYR0</accession>
    <name>E9FYR0_DAPPU</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87729"/>
    <dbReference type="EnsemblMetazoa" id="EFX87729">
        <property type="protein sequence ID" value="EFX87729"/>
        <property type="gene ID" value="DAPPUDRAFT_96728"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_96728"/>
    <dbReference type="eggNOG" id="KOG1082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_277605_0_0_1"/>
    <dbReference type="InParanoid" id="E9FYR0"/>
    <dbReference type="OrthoDB" id="753093at2759"/>
    <dbReference type="PhylomeDB" id="E9FYR0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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    <dbReference type="InterPro" id="IPR043550">
        <property type="entry name" value="EHMT1/EHMT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
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    <dbReference type="InterPro" id="IPR001214">
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    <dbReference type="InterPro" id="IPR046341">
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    </dbReference>
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        <property type="entry name" value="Ank"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00317">
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    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
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    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SSF82199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
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        <property type="match status" value="4"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="613"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="679"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="715"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="748"/>
            <end position="780"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="973"/>
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        <location>
            <begin position="45"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
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            <begin position="45"/>
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    </feature>
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        <location>
            <begin position="101"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <begin position="167"/>
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    </feature>
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        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87729.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1142" mass="126121" checksum="8D4B547114670503" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYR2</accession>
    <name>E9FYR2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_43232</name>
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    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_43232"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_064104_4_1_1"/>
    <dbReference type="InParanoid" id="E9FYR2"/>
    <dbReference type="OMA" id="RTHMQNS"/>
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    <dbReference type="PhylomeDB" id="E9FYR2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016573">
        <property type="term" value="P:histone acetylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TFIID_30kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="PTHR21242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
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    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX87579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="146" mass="15998" checksum="FFBD2201D6F10740" modified="2011-04-05" version="1">MDDDSNDANSPAENDQTTYEDLAAGPSVEPVEVGNTRTLGQPLSDFLMTLEDYTPTIPDAVTCSYLASSGFEASDPRIVRLVSIAAQKFISDIVNDALQHCKMRGANTVQSSKNKTKDKRYVLTMEDLAPALAEYGIQIRKPPYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYR5</accession>
    <name>E9FYR5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stripe/egr-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SR</name>
        <name evidence="5" type="ORF">DAPPUDRAFT_96734</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87728"/>
    <dbReference type="EnsemblMetazoa" id="EFX87728">
        <property type="protein sequence ID" value="EFX87728"/>
        <property type="gene ID" value="DAPPUDRAFT_96734"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_96734"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_441644_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="entry name" value="zf-C2H2"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236962" evidence="3">
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            <begin position="19"/>
            <end position="619"/>
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        <source>
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    </evidence>
    <sequence length="619" mass="65383" checksum="FADC16B8D64F2674" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZ38</accession>
    <name>E9FZ38_DAPPU</name>
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        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 2 subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
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        <name evidence="9" type="primary">EOG090X09RW</name>
        <name evidence="8" type="ORF">DAPPUDRAFT_306457</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
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    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CH-H</strain>
            <strain evidence="10">TCO</strain>
        </source>
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        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
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        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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    </dbReference>
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        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
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        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
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        <property type="entry name" value="TIF2_asu_middle_sf"/>
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        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
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        <property type="entry name" value="PTHR10602"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EIF_2_alpha"/>
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    </dbReference>
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        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
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        <location>
            <begin position="16"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="EFX87668.1"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="SVE83775.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="SVE84997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="333" mass="37169" checksum="A62201E03117C093" modified="2011-04-05" version="1">MPLFCRYYGQKYPEVDDVVMVNVRSIAEMGAYVHLLEYNNIEGMILLSELSRRRIRSINKLIRVGKTEPVVVIRVDKEKGYIDLSKRRVSPEDVDKCLEKYSKAKAVNSILRHVAELLKYQTDEELEELYRKTAWLFEEKSKKQSSSYDVFKQAVNDPSLLDECGLDDNTKEVLLGIIRRKLTQQAVKIRADIEVACYGYEGIGAVKKALKAGIACSTEEIPIKINLIAPPLYVMTTQTPERQDGLKGLELAIEKVKEIIVGLGGVFNIQMAPKVVTAMDEAELARQMEKAELENAEIAGDDDQSDMEAEGAGANDAGSGEEGGEEGEAEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZY3</accession>
    <name>E9FZY3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_44016</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Arnold G.J."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Yamagata H."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
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                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
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        <text evidence="8">Binds 1 zinc ion per subunit.</text>
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        <property type="entry name" value="SOD_Cu_Zn_dom"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SOD_CU_ZN_2"/>
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    <keyword evidence="7 8" id="KW-0186">Copper</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
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    </feature>
    <feature type="chain" id="PRO_5003240844" description="Superoxide dismutase [Cu-Zn]" evidence="9">
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            <begin position="25"/>
            <end position="177"/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Schaack S."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="616" mass="68434" checksum="EC6510609C8957F3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
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    </evidence>
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</entry>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="133" mass="14769" checksum="4240621F274C5F38" modified="2011-04-05" version="1">MTRQRQSLLQQLMVMVVVTAQVTLMLMLTTSVFPCDTAAAAAAAGPPWSSLATGPSDHAGLYCDFEDQQCRWQWSRFVRRSAAEINATIYSAPDPAMISGPLDDADGRPTGNWRWWPSILNRPSRGNKWRLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9G964</accession>
    <name>E9G964_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_315244</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:15621"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28257"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:133470"/>
            <dbReference type="EC" id="2.4.1.122"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="6"/>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84147"/>
    <dbReference type="EnsemblMetazoa" id="EFX84147">
        <property type="protein sequence ID" value="EFX84147"/>
        <property type="gene ID" value="DAPPUDRAFT_315244"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315244"/>
    <dbReference type="eggNOG" id="KOG2246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_580403_0_0_1"/>
    <dbReference type="InParanoid" id="E9G964"/>
    <dbReference type="OrthoDB" id="1407357at2759"/>
    <dbReference type="PhylomeDB" id="E9G964"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016267">
        <property type="term" value="P:O-glycan processing, core 1"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026842">
        <property type="entry name" value="C1GALT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF13">
        <property type="entry name" value="PTHR23033:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240121" description="N-acetylgalactosaminide beta-1,3-galactosyltransferase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX84147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="471" mass="53495" checksum="6C95044141860779" modified="2011-04-05" version="1">MSLAIVSLILIRALISVDLKNTNTLVAVELIGDVSPAPSKSFTFYHHWVWLLHHLVHEPITLHSIENIKEYANGIIIDDENNDLYSKVRVLCWVMTSPDNHKTKALAVKETWGKRCNILLFMSSVEDSALPTVNLPVHEGRNGLWGKTREAFRYAWNNYRDQADWFLKADDDTYVIVENLRYFLSAFNTSTPLWFGHKYKVIVKSGYFSGGAGYALSKEATRRFVEEGYFNALKCRHDHEGAEDAEMGKCMENLNVSTMDTRDSKGRGRFFPFVPEQHYFSGRITPSYWYWNNIYYPPTKGKDCCSDSAISFHYVNPQLMHIFDYLIYQLRPYGMPADQRPATPEPPPDLNLTALPWFAPPDEIITIPSTSTTERNSLLPPTMLNTTLSAQQNATRNQTQLNLTDANFSNSTNPENLVDLTTKIATTNIQTELNSTEANSFNLASPENLVELTPRTKRAGVVNKLRSAIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAH1</accession>
    <name>E9GAH1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_301829</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83240">
        <property type="protein sequence ID" value="EFX83240"/>
        <property type="gene ID" value="DAPPUDRAFT_301829"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301829"/>
    <dbReference type="HOGENOM" id="CLU_916044_0_0_1"/>
    <dbReference type="OrthoDB" id="1712895at2759"/>
    <dbReference type="PhylomeDB" id="E9GAH1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009832">
        <property type="entry name" value="DUF1397"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20997">
        <property type="entry name" value="PTHR20997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07165">
        <property type="entry name" value="DUF1397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240172" evidence="2">
        <location>
            <begin position="30"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX83240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="304" mass="33057" checksum="1834CEEC001A5B05" modified="2011-04-05" version="1">MKSQLVNSRTSLHALLLPFLLLFTPGSNSTSKLHLDEVIGDVVEKLFGAVVQDEFSELMDNCPDAYAALKKSGDCISDRNLSYQRFIRPSPDPSDVKQLCDDLATAGQCLESVIEALKSCANGKETRSQNIRVVGASLDASLKYFCDDGGSKLNQFFKQGLPQCFIRRPGRHLAKCFPGRITGLASDRHRNNNYWGPIGEDHDFFDAHNCQLLRNHTACAVGTLQKCSPDGVTDVFQGAIDTVMDELMCVGEKTEQVQEDSKSGGGAAGVSRVIHRSYLLMPMFALVISSGSIAGAWPASSVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAV6</accession>
    <name>E9GAV6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_100611</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tubulin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PhylomeDB" id="E9GAV6"/>
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        <property type="term" value="F:structural constituent of cytoskeleton"/>
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    </dbReference>
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        <property type="term" value="P:microtubule cytoskeleton organization"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="PTHR11588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="14"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="7">
        <location>
            <begin position="213"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX83325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="415" mass="46120" checksum="191B2935484561D7" modified="2011-04-05" version="1">MPSDKTIGGNDDSFNTFFSECGSGKHVPRAIFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRVRKLSDQCSGLQGFLIFHSFGGGTGSGFTSLLMERLSVDFGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEATYDICRRNLDIERPSYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPVISAEKAYHEQLTVGEITSSCFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVSRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGLDSVEGEGEGNDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBG4</accession>
    <name>E9GBG4_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_240390</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX83159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83159">
        <property type="protein sequence ID" value="EFX83159"/>
        <property type="gene ID" value="DAPPUDRAFT_240390"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_593491_0_0_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="59"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="461" mass="53609" checksum="FF38C1B0575A0843" modified="2011-04-05" version="1">MKVELLQEQVSAVEEQLEQKQGQCEMVNLPLEDTVQLLKDVLERISTQEELLRSSVELLSALQTQLQQVLSEREAMEEKASKFQEDNEVLRSQLYSLREKCNDSEEKIQLDLFKVQQVLDCEIAAHTETKMSAVKMLSDTKNALECQVNELQENFVVVERKKELVKQELDSERSAHSETKSDLELCKNLLEEDRNRHLLELSKVQDTVNILKDEKNQLKSEIDEFRGNLIAAFSQNESIMKELDDERKAHNEIMSYWKSCEDQLIQNAMKVLSDQNKFIEAEVNELKGNIGEAELQNKSIKQELDCEIKAHQEAKSNWKLANETKDEEIKQLKNLLKFFQSQHLDYDRQLNFSALEISKSYLVTQQLKKEKIELEKKLQEGAFPDAEIAVLQDVLPTKDKEVSYRDQAVSSVRSVADMTDEEEWMLSRKVKRHNPLIQKSKNEHLRHFSRLSKNRITGLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBZ3</accession>
    <name>E9GBZ3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_240618</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732538">
        <property type="protein sequence ID" value="EFX83042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83042">
        <property type="protein sequence ID" value="EFX83042"/>
        <property type="gene ID" value="DAPPUDRAFT_240618"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_240618"/>
    <dbReference type="HOGENOM" id="CLU_2742596_0_0_1"/>
    <dbReference type="InParanoid" id="E9GBZ3"/>
    <dbReference type="OrthoDB" id="1910048at2759"/>
    <dbReference type="PhylomeDB" id="E9GBZ3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:unfolded protein binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX83042.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="71" mass="8164" checksum="E10AE7089738079A" modified="2011-04-05" version="1">MEIECGKKILGRGGFGIVFEGFWGPNRIPVAVKRLQLLTLDNTEKEEEALIKLKHPNVNQIYHAENDKNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9GC01</accession>
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            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="106" mass="12856" checksum="17919B95CADAFCD4" modified="2011-04-05" version="1">MSFLELSNDYYWIAARYQESNNRWEWATVEPFQPNDYSNWFLGEPSNNAPGSFVYMNYIFDNGVWFDEVSTPRLIRMRINGRSVSHNIFYRWQWPRVARNLQSNQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9GC68</accession>
    <name>E9GC68_DAPPU</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX82914.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX82914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="416" mass="45588" checksum="6319EAC62076E24D" modified="2011-04-05" version="1">MPSLLGRFGHSAKLSSEEEMRTGRFLKKIATYRGKPAGNTNGNKYFSKMRSVNPLSTFMPCESTNGEDSGICLISPVCSYYGGKATDGFCKMGLTCCVNEVNSCGPLITFNNTYWQSPAIISSESSCGLTIKLDQHLIEQKKPICQIRLDFLTFSLAQPNAETICSVDSFQVAGAVNKIPTICGDNNGQHIYLMLPRISSSVQIVMTFGTSNIHRMWNIKIALLPCDADYLAPDDCLQYFTSPVGSIMTFNWKDKSSRITRQLAGQDYYICFRTELVNNHAIAQVATALCLSHCEVSSGLPFSLSGNVPGTSQAAGDESCTNDYIVFPGGFSLPPTIPIKQRDRFCGTTLSQVGSGNISQTICSTAKPFRLLYRTNGDESITPVVDANPLLGNQGFCLKYEQKFNLEIDRPLENED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDV4</accession>
    <name>E9GDV4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_223830</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX82148"/>
        <property type="gene ID" value="DAPPUDRAFT_223830"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_223830"/>
    <dbReference type="HOGENOM" id="CLU_1653880_0_0_1"/>
    <dbReference type="InParanoid" id="E9GDV4"/>
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    <dbReference type="PhylomeDB" id="E9GDV4"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF57625"/>
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        <property type="entry name" value="CHIT_BIND_II"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236917" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
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    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="104"/>
            <end position="160"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX82148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="160" mass="17649" checksum="A6AC8474A122E466" modified="2011-04-05" version="1" fragment="single">MAIRVATLCCFLLLVALATSAKIPPKKGHHFNQSSSKEQDKGSSSSERDSSEEVKLPVKRTTRAKPTTIEEITTTTTTAPTTIQELTTMPTTPDTTPTTEKSLLDFCKSLADGNYVNPVECKTFISCSNQITYIMNCPANLVYNQQFNWCDYSHNVPGCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9GFK3</accession>
    <name>E9GFK3_DAPPU</name>
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        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
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            <taxon>Anomopoda</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX81794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81794"/>
    <dbReference type="MEROPS" id="S01.A53"/>
    <dbReference type="EnsemblMetazoa" id="EFX81794">
        <property type="protein sequence ID" value="EFX81794"/>
        <property type="gene ID" value="DAPPUDRAFT_196039"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_196039"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_0_4_1"/>
    <dbReference type="InParanoid" id="E9GFK3"/>
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    <dbReference type="PhylomeDB" id="E9GFK3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:extracellular space"/>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S1_PA"/>
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    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
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        <property type="entry name" value="TRYPSIN_HIS"/>
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    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
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    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
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        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50494"/>
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    </dbReference>
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        <property type="entry name" value="TRYPSIN_DOM"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRYPSIN_SER"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
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    <feature type="chain" id="PRO_5003240945" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="69"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="311" mass="34392" checksum="780772A83EB8043E" modified="2011-04-05" version="1">MKLRSSILILLAAATAVTLAAVTETDRRLQRVTQLIERVKRQSVEEDAAAAASTTTSRCGQVQVSSFRVVGGELSQPGAWPWMTAIYLNGPKGTEFWCGGTLINERFIMTAAHCTLDGRQKRFRASQYTARFGEYNLRTTDPGESEIFQISEIRIHPQFTGTGFYNDLALFKLERPVSFSDYIQPICLPSNVQRSESFVGQVPTIVGWGTTYYGGRESTVLREVQLPVWRNDDCDRAYLQPITDVFICAGYADGGKDACQGDSGGPLMLQNEGTWTQVGIVSFGNKCAEPGFPGVYTRITHFLDWINANAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9GFN6</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_224137</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX81666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81666"/>
    <dbReference type="EnsemblMetazoa" id="EFX81666">
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        <property type="gene ID" value="DAPPUDRAFT_224137"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_224137"/>
    <dbReference type="eggNOG" id="ENOG502QWR9">
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    <dbReference type="OMA" id="YRKFGLE"/>
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    <dbReference type="PhylomeDB" id="E9GFN6"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF48371"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="646" mass="70929" checksum="D13340F250331A5F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIF5</accession>
    <name>E9GIF5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dipeptidase</fullName>
            <ecNumber evidence="3">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_211780</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="3"/>
    <dbReference type="EMBL" id="GL732546">
        <property type="protein sequence ID" value="EFX80779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="M19.A02"/>
    <dbReference type="EnsemblMetazoa" id="EFX80779">
        <property type="protein sequence ID" value="EFX80779"/>
        <property type="gene ID" value="DAPPUDRAFT_211780"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_211780"/>
    <dbReference type="eggNOG" id="KOG4127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031404_4_2_1"/>
    <dbReference type="InParanoid" id="E9GIF5"/>
    <dbReference type="OMA" id="GRCYDEC"/>
    <dbReference type="OrthoDB" id="1272387at2759"/>
    <dbReference type="PhylomeDB" id="E9GIF5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000180">
        <property type="entry name" value="Dipep_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00869">
        <property type="entry name" value="RENAL_DIPEPTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005128573" description="Dipeptidase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX80779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="417" mass="45882" checksum="AA4B11599D387499" modified="2011-04-05" version="1">MNWCVIVLALLLSTQKSWSYPSARFEEANSFEKYLEKARTVLDRVPLIDGHNDFPYSLRRYENNQVGDLDINDLTTSEPWASSSSSQTDINRLRQGKVGAQFWSAYVPCSTQYKDAILKTWEQIDVIHRMVDANPTAFEFVTSAQEIEDAFSRGKIGSLVGVEGGHSIGSSLAVLRMMYDMGVRYMTLTHSCPTPWGDNSQLDDPGNVPIHDGLTPFGKNVIAEMNRLGMLIDLSHVSRKTMRDALETSAAPVIFSHSSAYALCNNTRNVPDDILQLVAQNGGVVMVNFFVSYISCGLTATVQQVADHIEHIRNVAGADHVGIGSDFNGVARTPEGLKDVSEYPNLFAELLARGWAETDLEKVAGLNLLRVFRGAEAVRDQMAADGGKPFDEWIPQADLPAESLPCSTGQIKSVTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJ41</accession>
    <name>E9GJ41_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_3545</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80381">
        <property type="protein sequence ID" value="EFX80381"/>
        <property type="gene ID" value="DAPPUDRAFT_3545"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_3545"/>
    <dbReference type="eggNOG" id="ENOG502QW08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022576_0_0_1"/>
    <dbReference type="InParanoid" id="E9GJ41"/>
    <dbReference type="OMA" id="FNCEASA"/>
    <dbReference type="OrthoDB" id="1060206at2759"/>
    <dbReference type="PhylomeDB" id="E9GJ41"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="350" mass="40139" checksum="C1C4FC10D8851FAF" modified="2011-04-05" version="1" fragment="single">KCLLPDCLCMGTAVPNGLNPEEIPQMVFLTFDDAVADVMYPTYQRILHNRTNPNGCDIGMTLFVTHEGTNYRLVNQLFKRGNEIASHTVTHKMDYDYWKNTSADFWLREVGYQRHLLHSYGNIPFDTIQGFRSPFLQTGGDATLTALRMLGMSYDSSFTTMQFMDPPVWPFTMDYGAPRECHIPPCGNESHPGFWNIPMVEFRSSDNGFPCKTADTCFAPDKPEASNLTADEIFHYFVFNFNRFNKNRAPFGIHQHMYWFLNNEPILEGFLRFLDYLATLDYVYIVPISKAKWMKNPKTLKQLKDKDVFNCEASAAPCPKPQVCYYTKSVPGGARFMGTCVPCPAEYPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJ73</accession>
    <name>E9GJ73_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_103402</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80536"/>
    <dbReference type="EnsemblMetazoa" id="EFX80536">
        <property type="protein sequence ID" value="EFX80536"/>
        <property type="gene ID" value="DAPPUDRAFT_103402"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_103402"/>
    <dbReference type="eggNOG" id="KOG4271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_478390_0_0_1"/>
    <dbReference type="InParanoid" id="E9GJ73"/>
    <dbReference type="OrthoDB" id="1300981at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050770">
        <property type="term" value="P:regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP_dom"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="146"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX80536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="570" mass="64859" checksum="98D8BCD2E4B3754E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJE7</accession>
    <name>E9GJE7_DAPPU</name>
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        <recommendedName>
            <fullName evidence="2">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="2">3.4.-.-</ecNumber>
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    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_304127</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M2 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="2"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80442"/>
    <dbReference type="MEROPS" id="M02.003"/>
    <dbReference type="EnsemblMetazoa" id="EFX80442">
        <property type="protein sequence ID" value="EFX80442"/>
        <property type="gene ID" value="DAPPUDRAFT_304127"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304127"/>
    <dbReference type="eggNOG" id="KOG3690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014364_3_3_1"/>
    <dbReference type="InParanoid" id="E9GJE7"/>
    <dbReference type="OMA" id="WPEYNDS"/>
    <dbReference type="OrthoDB" id="422699at2759"/>
    <dbReference type="PhylomeDB" id="E9GJE7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX80442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="624" mass="71578" checksum="7F9F9E99350A9633" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80489">
        <property type="protein sequence ID" value="EFX80489"/>
        <property type="gene ID" value="DAPPUDRAFT_224791"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_224791"/>
    <dbReference type="eggNOG" id="ENOG502TGMF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_344271_0_0_1"/>
    <dbReference type="OrthoDB" id="1596029at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF49854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="654"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX80489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="822" mass="90279" checksum="072CFAD3A1A178FE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJV9</accession>
    <name>E9GJV9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_197078</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732548">
        <property type="protein sequence ID" value="EFX80182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80182"/>
    <dbReference type="EnsemblMetazoa" id="EFX80182">
        <property type="protein sequence ID" value="EFX80182"/>
        <property type="gene ID" value="DAPPUDRAFT_197078"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_197078"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021458_3_2_1"/>
    <dbReference type="InParanoid" id="E9GJV9"/>
    <dbReference type="OMA" id="YTMIYLA"/>
    <dbReference type="OrthoDB" id="1354951at2759"/>
    <dbReference type="PhylomeDB" id="E9GJV9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042577">
        <property type="term" value="F:lipid phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PA_PP_rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="PTHR10165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="4">
        <location>
            <begin position="117"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX80182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="301" mass="33902" checksum="89CF1B15377B2C93" modified="2011-04-05" version="1">MAAAALIRQVVIDFICLAIVWLPVLLLHLLGKAFQRGFYCDDASIRYPFKESTVTNVVLYCYSLGLPILSMIIIEIFRWRNNSNNSKRLTRQNSASTINISSAIRIPSVIAELVHLVAIFLFGAACSQLATDFGKYTIGRLRPHFIAVCQPENFAQLCPLDGPPTYITDYKCTGSDEKLLRESRLSFPSGHSSFSAYTMLFLAFYLQRRMNWSGSKLLRPTIQICVLMLSWYTGLSRVSDYKHHWSDVLSGFLIGAIAASLTALYVSRLFQPSIRRDMALVPQSREDVEMQQNHLQASAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKH7</accession>
    <name>E9GKH7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3819 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_244230</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732549">
        <property type="protein sequence ID" value="EFX79994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79994"/>
    <dbReference type="EnsemblMetazoa" id="EFX79994">
        <property type="protein sequence ID" value="EFX79994"/>
        <property type="gene ID" value="DAPPUDRAFT_244230"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_244230"/>
    <dbReference type="eggNOG" id="KOG1831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1504962_0_0_1"/>
    <dbReference type="InParanoid" id="E9GKH7"/>
    <dbReference type="OrthoDB" id="42530at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="PTHR13162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3819" evidence="1">
        <location>
            <begin position="41"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX79994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="179" mass="20469" checksum="EB20D83321BEEBC3" modified="2011-04-05" version="1">MCQQVPQLQIIQQQKQQQTTPPNNLLALLHNKCNPSLTQLLQHQLHHTVHSLSVGTTLIRCREHLLLTITNNLKTAFSAILQRSTRPQRKELVEQAATLSAQENVEPACAFIHNTAAKKSISEIDKRLATEFYLRKHVRNKGRRYDYDPIVFAYQADRMPEPIHLKMSGVTPQQAGVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKR4</accession>
    <name>E9GKR4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_197160</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732550">
        <property type="protein sequence ID" value="EFX79923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79923"/>
    <dbReference type="EnsemblMetazoa" id="EFX79923">
        <property type="protein sequence ID" value="EFX79923"/>
        <property type="gene ID" value="DAPPUDRAFT_197160"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_197160"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_1"/>
    <dbReference type="InParanoid" id="E9GKR4"/>
    <dbReference type="OMA" id="CTFLTWN"/>
    <dbReference type="OrthoDB" id="519426at2759"/>
    <dbReference type="PhylomeDB" id="E9GKR4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="294"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX79923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="528" mass="59764" checksum="205428AB555619AC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9GLR1</accession>
    <name>E9GLR1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_4269</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732551">
        <property type="protein sequence ID" value="EFX79550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79550"/>
    <dbReference type="EnsemblMetazoa" id="EFX79550">
        <property type="protein sequence ID" value="EFX79550"/>
        <property type="gene ID" value="DAPPUDRAFT_4269"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_4269"/>
    <dbReference type="eggNOG" id="KOG0542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037266_4_3_1"/>
    <dbReference type="InParanoid" id="E9GLR1"/>
    <dbReference type="OMA" id="CRIMEAL"/>
    <dbReference type="OrthoDB" id="809000at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="4"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX79550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="199" mass="22829" checksum="2F49DDBE90164F49" modified="2011-04-05" version="1" fragment="single">HFDYFVIIDFEGTCGFLKNPCGIQEIIEFPAILLNGHNGSIEDEFHSFCQPVLNPSLTNFCKKLTGITQDAVDKAPLFKDVFVSFEEWLKKNKVIGSYYSFAVVTDDPNDIRQFLQKQCRISEIDFPTYCQNWINIKIIFAHFYKNGNMQCLSLKNMIRDIGCEFQGRAHSGIDDARNIASIVQRLLADRAPITFNEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9GNE9</accession>
    <name>E9GNE9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CASPASE_P20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_225308</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732554">
        <property type="protein sequence ID" value="EFX79017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79017">
        <property type="protein sequence ID" value="EFX79017"/>
        <property type="gene ID" value="DAPPUDRAFT_225308"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_225308"/>
    <dbReference type="HOGENOM" id="CLU_608687_0_0_1"/>
    <dbReference type="InParanoid" id="E9GNE9"/>
    <dbReference type="OrthoDB" id="1092723at2759"/>
    <dbReference type="PhylomeDB" id="E9GNE9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097153">
        <property type="term" value="F:cysteine-type endopeptidase activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097200">
        <property type="term" value="F:cysteine-type endopeptidase activity involved in execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="PTHR10454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASPASE_P20" evidence="2">
        <location>
            <begin position="221"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX79017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="450" mass="51454" checksum="7A027703545D3B2E" modified="2011-04-05" version="1">MAKSLLSVSFIRSIEDSMDWYDHIAFSFLLFKQGDELVALEQMQRLIKLHERGCPEWKRVAIHLAIQSAEMNPSAVIEALFQLKQWKLLRLIGYSVSTPIEYIPRGHLFPFRVGIFCVLDQLDRYDAHLLQSFINSMDATNEFQVIEVVVLQWIVNGIISTNDCSKLTIALGRIGRNDLVNLSLQLQSGRSGTSSMRDECFNQSISRHSTIGNNRLHTSSSIGYCLIVHQKNIYRERDPILKHRVELDVPNYQGNEADCRTLRETFLSLGYQVEIAEDLTNFELKQKVLDVSRGVDWTRYNGLTLCFLSHCIQGQILGSNSLTISFNKDVRKYFNECYCPGLKGKRKAIIFSTPFGSAGWNPVSQLECVGGYNPHLYDNFLVIWPTSYVLSVSNGGSQFITEFSTELKKSNAANDITLASFRTAISTINNRNNLTRYRKRQFWSIQQWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9GP29</accession>
    <name>E9GP29_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_320173</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732556">
        <property type="protein sequence ID" value="EFX78754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78754"/>
    <dbReference type="EnsemblMetazoa" id="EFX78754">
        <property type="protein sequence ID" value="EFX78754"/>
        <property type="gene ID" value="DAPPUDRAFT_320173"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_320173"/>
    <dbReference type="eggNOG" id="ENOG502QRD8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034851_2_0_1"/>
    <dbReference type="InParanoid" id="E9GP29"/>
    <dbReference type="OMA" id="RWYKATI"/>
    <dbReference type="OrthoDB" id="885529at2759"/>
    <dbReference type="PhylomeDB" id="E9GP29"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="Nucleoporin_p58/p45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="PTHR13437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX78754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="479" mass="50296" checksum="3948377B4A4DB752" modified="2011-04-05" version="1">MSFNLTSNQPSQPSAFGTPSFGNPAPSNSSFSFGSGPATLTSSAAPFSFGTTTAPQQTGGFQMGTSNASSTGGFGFGSTSQAAPAFSFSSAPLNTGTATTSMTGAFFGFGAPSSTGFGVGAVSSAPFTGLTTNVIPTTTTAPSLGLGGVSIWRGTPFGDSLSASNSQGKSDSKAFNEMPVPAEISQSVEEFKKHVKEQKAKKDEVSRGSNKAPEKVGEEVETLKNILSNLANNIQQHSALVHKLKHDVALEIKNAEIAQRTKETAPSMQLDNTAPLEYFMRLVTDFEQRMQFYKQQIEDTERNLLAMTKQHALTPQELMGTMKKLHEAFVLLAGRVHMIHTSLQNYKDDYLTYRRRVLNDPTDIFASKSHAPSKSVLVSQLNKIGSGPSPFGGTSDPLSRTLSHLTNAVQGSGAVLSGGTSGGLSFGSSLASSSNPGSLSFGTPSRPAGFFGSSAQSLQSANSSFQLQSPPPGNKRNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQ66</accession>
    <name>E9GQ66_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_213162</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732558">
        <property type="protein sequence ID" value="EFX78220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78220"/>
    <dbReference type="EnsemblMetazoa" id="EFX78220">
        <property type="protein sequence ID" value="EFX78220"/>
        <property type="gene ID" value="DAPPUDRAFT_213162"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_213162"/>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012184_8_1_1"/>
    <dbReference type="InParanoid" id="E9GQ66"/>
    <dbReference type="OrthoDB" id="1275401at2759"/>
    <dbReference type="PhylomeDB" id="E9GQ66"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="SSF57625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="5">
        <location>
            <begin position="222"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX78220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="278" mass="30125" checksum="60EC82720DE3F4D1" modified="2011-04-05" version="1">MDYRNDPCMPPVRNQGGCGSCWAYTASAVVEFGKCKKSGGNAIDLSEQQIVDCSLGSGCSGGWEHEAWKYLASCGGHALESSYPYAGRDGACRFSPTGMTIGAKLLTSIPVEWVPSKDTSTMMNILSDGRILTVYIHLPDSFFNYKSGIFDDTKCNSGSAHALNPVGYGTLNGVDYWVMRNSWGAGWGSSGYVLVKRGIDLCLIESYARTTNIDTTTTTSLENFCTNRPNGNYANPNECQSYISCSNGSAYKMNCPSGLAFNEKYNSCDYIYNVPGCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQV4</accession>
    <name>E9GQV4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_105452</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732558">
        <property type="protein sequence ID" value="EFX78264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78264"/>
    <dbReference type="EnsemblMetazoa" id="EFX78264">
        <property type="protein sequence ID" value="EFX78264"/>
        <property type="gene ID" value="DAPPUDRAFT_105452"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_105452"/>
    <dbReference type="eggNOG" id="KOG1027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319398_0_0_1"/>
    <dbReference type="InParanoid" id="E9GQV4"/>
    <dbReference type="OMA" id="HFASEYN"/>
    <dbReference type="OrthoDB" id="1115202at2759"/>
    <dbReference type="PhylomeDB" id="E9GQV4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="entry name" value="SSF48403"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="5"/>
            <end position="276"/>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="317"/>
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        </location>
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            <begin position="391"/>
            <end position="427"/>
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        <location>
            <begin position="428"/>
            <end position="464"/>
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        </location>
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            <position position="32"/>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <sequence length="1021" mass="113689" checksum="52689375DE01EBEA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GS30</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">DAPPUDRAFT_305346</name>
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        <name type="scientific">Daphnia pulex</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </feature>
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    </feature>
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    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="270"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX77632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9GSS6</accession>
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        <recommendedName>
            <fullName evidence="4">Carbonic anhydrase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CAA7Q</name>
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    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Koonin E.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="4">Reversible hydration of carbon dioxide.</text>
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    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-carbonic anhydrase family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="339" mass="39452" checksum="40F43AD3628AE5EE" modified="2011-04-05" version="1">MVEKCSLTCQVYMLSVNFFRIWRPLIASFLSWNEQRSHCGGQHQSPINIESNKGFLANYPEFIFHQYDRVFPEILKNDGHTVELKIEEQGEELPFITGGGLGDRYNFVQLHFRWGESVRGSEHIINGKQYPAEMHIVHYNSKYGNFNDALTQADGLSVLGVLIELQPWDNIAFRHLEQFDNIVNPSTTNTDALQFSVPLSELLPDNTSSFFRYNGQLTTGNCNEDVTWTIFDTPFAISERQLAKFRLLLIDDNGNRLRQKVRPTQLLHERVVMYPLPRYCPLLPRYDRFIRTEFQSNKSICLYSQRFQMYFNQIKQSCKSVDCTVLTPIRLSAPQLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
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        </lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX77350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="86" mass="10100" checksum="63A1E2A9C5CF4817" modified="2011-04-05" version="1" fragment="single">GLQAACASDYSIAQFRFLHRLLLVHGASSYYRMSQFILYSFYKNVTLYMIELWFEYYSAWSGQSYDPLVFTRYCSLPLFTFSPGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GT98</accession>
    <name>E9GT98_DAPPU</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX77240.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="EFX77240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="298" mass="34692" checksum="1556861D06CA1B79" modified="2011-04-05" version="1">MAYDDSQLEHISKIEKKIPKAKGKGDDLCGSSTWKAAKGETSSKRNLDITGLEMMSCTHGTVVYSANLFKGEIFKHTHLQHLKSHEMGTKFFCNDVVCKYWPFAIKVGHLFPEYQQLTKDMKPFLSRFHGLGHSWTCRVLYNGHWEKGGADMLGEEQEQVFSYMARLGATTKHQSKASRRDDVTSAILYFNSEKEKRMVTALCLWMNRAKERSLLYRKKLQNTLEHRDVKEEEPPSILDRLKKQAKLVNSKILTNDWDKQLLQKELEGECHMLKVLQARNANFFGKFFQERMFFLHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9GUL3</accession>
    <name>E9GUL3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_248405</name>
    </gene>
    <organism evidence="5">
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        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cladocera</taxon>
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            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732566">
        <property type="protein sequence ID" value="EFX76914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76914">
        <property type="protein sequence ID" value="EFX76914"/>
        <property type="gene ID" value="DAPPUDRAFT_248405"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_248405"/>
    <dbReference type="HOGENOM" id="CLU_2529735_0_0_1"/>
    <dbReference type="OrthoDB" id="1593743at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF57756"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX76914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="84" mass="9251" checksum="505296E3EC56E984" modified="2011-04-05" version="1">MEALTSQVAVLARTVNRPASPGALKPAIKQVGFERRPPGSRNEIQCYNCNDYGHISRDCPSPNPHWNQPRPENESADPSGQSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9GUW8</accession>
    <name>E9GUW8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATOR complex protein NPRL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nitrogen permease regulator 3-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_54916</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NPR3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX76720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76720"/>
    <dbReference type="EnsemblMetazoa" id="EFX76720">
        <property type="protein sequence ID" value="EFX76720"/>
        <property type="gene ID" value="DAPPUDRAFT_54916"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG3830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9GUW8"/>
    <dbReference type="OMA" id="CLPQKVH"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX76720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="526" mass="59008" checksum="92C74906F0D0C538" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9GVT0</accession>
    <name>E9GVT0_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_249060</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX76465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76465">
        <property type="protein sequence ID" value="EFX76465"/>
        <property type="gene ID" value="DAPPUDRAFT_249060"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="135" mass="15680" checksum="C5D7D97EA4F82AE2" modified="2011-04-05" version="1">MHNHYKNCMIERVCPICRTRPRFKSESGFRKHALMHKQNVQPLIFGIGRPTSTEPIRTTLPEMKVVLKEIPIPKSSNVQETTTENDDDVEIIPEEIPIPESSKVQETTKKESDNDGHFSRDEFLARIEKLPYHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9GXF9</accession>
    <name>E9GXF9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_249883</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732572">
        <property type="protein sequence ID" value="EFX75861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75861">
        <property type="protein sequence ID" value="EFX75861"/>
        <property type="gene ID" value="DAPPUDRAFT_249883"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_249883"/>
    <dbReference type="HOGENOM" id="CLU_060623_0_0_1"/>
    <dbReference type="OrthoDB" id="279711at2759"/>
    <dbReference type="PhylomeDB" id="E9GXF9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="314" mass="35276" checksum="8770B0598DB166D1" modified="2011-04-05" version="1">MAKNKKRDPRYIKSRAVKNSAKKAAAAAVLKRQQLKEAKEREAGNNEPSIDTDTGHEAQNNVEESVASEEPVEEPGQELEPEREPVLDQGPADEEEPIAEKEKETANEEPPVKVKTVVNLKKVTVRLERLAFNPNGSTKAKKNKAQDADLEGGSSPPEKRRRMTRSTAKVGCSSDGQVTDDEVTRYFARKKIGLTNAKLRHRGPRSSKGHPSMAPKKVNSDAVKLRMQQKADAKLIAHHKAINKHWKGVSYWSDVEEDYQENDDENQETQYREYSYEFTPEKPVGPYFLSSIRMILLSTSFGLCLADSKLLIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZA7</accession>
    <name>E9GZA7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_250795</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732577">
        <property type="protein sequence ID" value="EFX75115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75115">
        <property type="protein sequence ID" value="EFX75115"/>
        <property type="gene ID" value="DAPPUDRAFT_250795"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_250795"/>
    <dbReference type="HOGENOM" id="CLU_1940225_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="130" mass="15096" checksum="7A5B27816737F8AD" modified="2011-04-05" version="1">MPLIMEIIFGAHFHGSQKVAAKEKFTAPREIIFAEIKKKKSITRRDMPPVDKTTRHIRYLRSQFLPTNQRKDETFCREPNVDRNGSSCGYVNLKKSCVMESLSGKLEFHTFLRNNKFSLSSYPLPSKRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9H112</accession>
    <name>E9H112_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_307219</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732582">
        <property type="protein sequence ID" value="EFX74550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74550">
        <property type="protein sequence ID" value="EFX74550"/>
        <property type="gene ID" value="DAPPUDRAFT_307219"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307219"/>
    <dbReference type="HOGENOM" id="CLU_919077_0_0_1"/>
    <dbReference type="OrthoDB" id="1722137at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX74550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="303" mass="33562" checksum="5F358A9895D1129E" modified="2011-04-05" version="1">MTGRYPGSVRGNPRLTPLMMSSFSRLHESSLNRTADSGYQSSFASLTNSFTPSSDVSDSSSRLYCSTPVTEDSILPYTTTNLDPVLDTPVQSVSSSRASFTEDRVPLNRGTTALDQRSTECPNDVLSCLIRGRCAPSIQRILMYLGDEDLMRLCQVSDEYCGAVCDDQSCLKRLSKFLISTQQNGENRTTLSHNNDGRPYGGVLRPIQNVMPLTQSGVVWTVPSPLESVDMNSIPRQLRTLIGMTRTLSEHHCVTNCHTCRSLIAVRLHHHKSVECQRCSQRSGRKIGSSRPVTKAKLFATHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2C9</accession>
    <name>E9H2C9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_109234</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732585">
        <property type="protein sequence ID" value="EFX74152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74152"/>
    <dbReference type="ESTHER" id="dappu-e9h2c9">
        <property type="family name" value="Chlorophyllase"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74152">
        <property type="protein sequence ID" value="EFX74152"/>
        <property type="gene ID" value="DAPPUDRAFT_109234"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_109234"/>
    <dbReference type="eggNOG" id="KOG4686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_788143_0_0_1"/>
    <dbReference type="InParanoid" id="E9H2C9"/>
    <dbReference type="OrthoDB" id="1174473at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041127">
        <property type="entry name" value="Chlorophyllase2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12740">
        <property type="entry name" value="Chlorophyllase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241457" evidence="1">
        <location>
            <begin position="19"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="352" mass="38551" checksum="41E1ED7478D01228" modified="2011-04-05" version="1">MKTTLYLLVGLLASVTVAGNIIHVDDDDLSRLIDPFIPGDYAINHTAYRQALTLFLDTNIDVYAPNSTGNFPVFYFITGFGGIVPAEAHTLLLSQIASHGIVVVAVWKLGSPETSFDPAWFETTVDFVENRLENSLHNQEGYISDFHVDYLHSFIGGHSGGSHVAVAQFQTNCLNYQGLILIDAVDGNSPIPENITMFVITPGQKVNFTVPTLQIVTGLDPVIGPYGLAFAPEELSGRRFFDAMTGPTWYVNATAYGHADLMDPVYVELNEITQFCPSDPSAPKEEYIQFLTGEIISFINGVLGPVEKCAFFDYLEMSGLVGINTENDFVSNGWERCSPLQCVLTPSSDLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2F8</accession>
    <name>E9H2F8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome-b5 reductase</fullName>
            <ecNumber evidence="3">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_34463</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="GL732586">
        <property type="protein sequence ID" value="EFX73972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX73972"/>
    <dbReference type="EnsemblMetazoa" id="EFX73972">
        <property type="protein sequence ID" value="EFX73972"/>
        <property type="gene ID" value="DAPPUDRAFT_34463"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_34463"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1499944_0_0_1"/>
    <dbReference type="InParanoid" id="E9H2F8"/>
    <dbReference type="OMA" id="HFREMHE"/>
    <dbReference type="OrthoDB" id="1311668at2759"/>
    <dbReference type="PhylomeDB" id="E9H2F8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="PTHR19370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX73972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="180" mass="20801" checksum="5EF832594CE4FB1E" modified="2011-04-05" version="1" fragment="single">NTKMNPETYVDCVIESVEPVCPSVFLFHFKLPENHCMEFSASQHLIARESTSNSTISRPYTLISSPGLVTKFTVLIKLYDNGMMSNIIKRKWLTGKVVSWRGPIGQCDYKPNSYRNVLMIAAGTGITPLYQITKLIIDNPDDETRVFLLYGCRTYSEIIFQREFHQLQDYWNFKACYFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5Q1</accession>
    <name>E9H5Q1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DAPPUDRAFT_325673</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732594">
        <property type="protein sequence ID" value="EFX73049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX73049"/>
    <dbReference type="EnsemblMetazoa" id="EFX73049">
        <property type="protein sequence ID" value="EFX73049"/>
        <property type="gene ID" value="DAPPUDRAFT_325673"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_325673"/>
    <dbReference type="eggNOG" id="KOG1565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_511194_0_0_1"/>
    <dbReference type="InParanoid" id="E9H5Q1"/>
    <dbReference type="OrthoDB" id="1075463at2759"/>
    <dbReference type="PhylomeDB" id="E9H5Q1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033595">
        <property type="entry name" value="Zmp-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF280">
        <property type="entry name" value="PTHR10201:SF280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="SSF49842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240858" description="C1q domain-containing protein" evidence="12">
        <location>
            <begin position="18"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="13">
        <location>
            <begin position="309"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFX73049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="465" mass="52967" checksum="2A61058389E8FDBF" modified="2011-04-05" version="1">MFFIVMLLGVVVNHLDSTPLSYTEAQSYLASFGYLHPRYKNTSNSIISGYFFELAVKNFQSFFGLNLTGELDEETKKEMRKPRCGHPDQIIPEDSSTQRKRNINNKGNRWTKNELTYGIRKYTPDLEKSVVDREIAKAFQLWEEVTPLTFTFVETGNVDIEISFESGAHSDSRNHDAFHGPGTTYAHAAFPPSGDTHFNDAETWTISSDGINLFQVATHEFGHALGLAHFESKTDVMFAYYDYRLNFKLEPNDINRIQQLYGINNKWLKKKLDEITTDVKNLKIKLEETKKELDGAKNTIAKLETNGHTNVKSTAFYFYVQRNSPFNEDKIAIPFDVARVNNGNAMDFSSGEFLAPKSGIYFFSFTGLASFPETKSPNKVQLEIGLYLSGKRVGRALAEESNTVANQKCPLSLQSTLKLEKHDNLWLQIDFKSTPEVFLYDEAGPGRDGHWTHFTGWMLQEEILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5Y0</accession>
    <name>E9H5Y0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_253916</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732595">
        <property type="protein sequence ID" value="EFX72802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72802">
        <property type="protein sequence ID" value="EFX72802"/>
        <property type="gene ID" value="DAPPUDRAFT_253916"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_253916"/>
    <dbReference type="HOGENOM" id="CLU_1148227_0_0_1"/>
    <dbReference type="OrthoDB" id="1077410at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="PTHR12243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="6"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX72802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="242" mass="27960" checksum="A4436737C0FC66AA" modified="2011-04-05" version="1">MLRPGEVKRKWKQLKDDYRSEKKRLNEEDPSGSGLEGSKRVKKPWTYFGGMGFMSTVHEDAERVTNMDEEDEEGKRNEYEEEEGKPIQMIIFDQEIQTFSMNNVEIESDVSDHSVVIEMLDSISSDSYYLETIEGRKEPDFKAPISPAPIKKASPEGEAAKGIGQIMKSIEQVLESKPEVKKSNPPERILNEIQEEWITYCKSLAFRVAAIDDEESRDNIRHEFEQAIYHAKQDLKKKKPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9H620</accession>
    <name>E9H620_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_215749</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732595">
        <property type="protein sequence ID" value="EFX72822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72822"/>
    <dbReference type="EnsemblMetazoa" id="EFX72822">
        <property type="protein sequence ID" value="EFX72822"/>
        <property type="gene ID" value="DAPPUDRAFT_215749"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_215749"/>
    <dbReference type="eggNOG" id="KOG1582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036019_2_0_1"/>
    <dbReference type="InParanoid" id="E9H620"/>
    <dbReference type="OMA" id="QFGYYIG"/>
    <dbReference type="OrthoDB" id="1116466at2759"/>
    <dbReference type="PhylomeDB" id="E9H620"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030176">
        <property type="term" value="C:integral component of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030173">
        <property type="term" value="C:integral component of Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="UAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="PTHR10778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX72822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="379" mass="41763" checksum="163D44E11A62EC98" modified="2011-04-05" version="1">MKSVNDSAILVESNKLSGFGHSNKSSNVYQEPVSVTILGVNISHLTQTTQFVLVSSGVFIFFVLYGYFLEAIFVQPNLKSHGLYVTFIQFVLYSLFAIIESQLKKDTERRIPVPTYILISFLTVATMTMSNLSLEYLNYPTQVIFKSCKLIPVLVGGIIIQGKKYGTRDFLAAAVMCIGLIWFTLIDVTISLNFHPAGVLMINLALVADAVIGNVQEKAMKKYGASNSEVVLYSYSFGIIYLLVALILSGRLIPAITTANQFPVSIYGLGFLLSITGYMGVNLVLTLVRVAGAFAAVTVTTCRKALSIVVSFIFFTKPFTPQYVWSGCLVVLGVYLNVLSSQRQQSHLIFIKNNFINTAINYVKRLVTRKKLAKAAISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6T0</accession>
    <name>E9H6T0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ANAPC4_WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_308214</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732598">
        <property type="protein sequence ID" value="EFX72563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72563"/>
    <dbReference type="EnsemblMetazoa" id="EFX72563">
        <property type="protein sequence ID" value="EFX72563"/>
        <property type="gene ID" value="DAPPUDRAFT_308214"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_308214"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin ligase activator activity"/>
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        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
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        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Apc4_WD40_dom"/>
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        <property type="entry name" value="Cdc20/Fizzy"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="PTHR19918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="216"/>
            <end position="277"/>
        </location>
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    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
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            <begin position="304"/>
            <end position="345"/>
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            <begin position="439"/>
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            <begin position="1"/>
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            <begin position="478"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX72563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="501" mass="55458" checksum="EF482590002F082D" modified="2011-04-05" version="1">MNLSEVNLMSNKKENHLSSAKHDQSAKLGKSLCNGSINMSLNCSTNSQSVVAKTPKRTETSFSNNKTPKMTQGPTLGKPNSWKSPGVGGGACRKAQNILGDRMVPSRSTTDFEAAHHKMTSEESSGDRVLSYQTVQIPKPQEAYINHQKALYSATASAQKKPSNRFIPNTADRVLDAPAMMNDYYLNLLDWSQTNFISVALDKQVYLWNAASGDIQELMECEGEDNYISSVQFTQDGSYLAIGLNTGSVELWDIQQQRRLRTMAGHAARIGVLAWNEHVLSSGSRSGLIFHHDVRIPQHLVASLEGHTQEVCSLKWSGDHRYLASGGNDNLVHIWEGTTGQTTRNTPVHVFNQHQAAVKGMAWCPWQNRLLATGGGSNDRSIKLWNMNVGECVDTIDTKSQVSGIFWNTEYQEIISAHGFPNHTLQIWKYPTKAKVAELTGHDERILHLAMSPGETAVMSAGADETLRLWNCFQTDPNKKKGTAGRRNEPRSALDAMSNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9H851</accession>
    <name>E9H851_DAPPU</name>
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        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_254887</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732603">
        <property type="protein sequence ID" value="EFX72089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72089">
        <property type="protein sequence ID" value="EFX72089"/>
        <property type="gene ID" value="DAPPUDRAFT_254887"/>
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    <dbReference type="eggNOG" id="KOG1075">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
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        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
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        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX72089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="247" mass="27693" checksum="26C754051A3243F8" modified="2011-04-05" version="1">MLRQYSREELMSFNRPAPPSIPQSRFIRLRLSGLCLFRPTKRPKKRRHRTDQKQYQPSLTAKLCLLNARSIVNKIEALNELVSDARPDILAITETWLTPTNGDHELAACCPSGFSAVHQPRASRRGGGVAVIFKSTISVRRHSHPTFNSFELIDCSLSLRPIAIRLLVVYRPPASSHSVFRDEFSSLLEQIALTNEKLLIVGDFNLSIRDQPDDAAQRLLDSTEAFGLSQLVTSATHEGGSILDLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9H8T8</accession>
    <name>E9H8T8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_308709</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732605">
        <property type="protein sequence ID" value="EFX71868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71868"/>
    <dbReference type="EnsemblMetazoa" id="EFX71868">
        <property type="protein sequence ID" value="EFX71868"/>
        <property type="gene ID" value="DAPPUDRAFT_308709"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_308709"/>
    <dbReference type="eggNOG" id="KOG2147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008874_1_0_1"/>
    <dbReference type="InParanoid" id="E9H8T8"/>
    <dbReference type="OMA" id="KSKMHKY"/>
    <dbReference type="OrthoDB" id="950459at2759"/>
    <dbReference type="PhylomeDB" id="E9H8T8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="PTHR23183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="807"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="807"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX71868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="843" mass="96231" checksum="638652B06A31D073" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HBD2</accession>
    <name>E9HBD2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_228140</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732615">
        <property type="protein sequence ID" value="EFX70965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70965">
        <property type="protein sequence ID" value="EFX70965"/>
        <property type="gene ID" value="DAPPUDRAFT_228140"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_228140"/>
    <dbReference type="HOGENOM" id="CLU_696901_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="396" mass="45060" checksum="97A074F0040C6B31" modified="2011-04-05" version="1">MKKNRVTKGGKGKRYSLSFRQFAVKRIRSHTFFNEFALHKEISGHKGHHLHTISVAIKKKKQKESACSIWMKFKILKQESSDSRAESEHETRVLEAWLDSDDEETAHESDAKSISLHVTSVSTSPNPGVTPSAMNIIPDVEQRALFSGTSVLSSPRISLLMLNNAEKSCLEAAELRKQLRNSIGGVEHLSHEKFEDTNKMLLNGGSTVTLAADQATFPASMCLISNYKTDKMLYSDQNAYDYPDKLKNVVKNPETKIVEDFDAAMQQPSINFNLNRPSVIITNVVVERSCHKREVIYYDGPKVHASSTMLKKFVYHRFKLLSSTEKTTFLCFRIFEQRLERQRSGYGRKDCSNQYSPIFWFFLASLQGHKMKSLGPTGCCRGVFQLIFHQRISLCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9HD11</accession>
    <name>E9HD11_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_112776</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL732622">
        <property type="protein sequence ID" value="EFX70294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70294">
        <property type="protein sequence ID" value="EFX70294"/>
        <property type="gene ID" value="DAPPUDRAFT_112776"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_112776"/>
    <dbReference type="HOGENOM" id="CLU_022631_1_1_1"/>
    <dbReference type="InParanoid" id="E9HD11"/>
    <dbReference type="OrthoDB" id="1046329at2759"/>
    <dbReference type="PhylomeDB" id="E9HD11"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="2">
        <location>
            <begin position="333"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX70294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="477" mass="52584" checksum="382AD3CD4C8E7013" modified="2011-04-05" version="1">MYHNHNVKVQPPEYRLHKTEQSGRSFTMVHDKACDNNNNDEQPPAIAREDSEDYFDKSHEILLDTWNYGKSLYYEPSALLSVYDGLYRHPEGRTLSNRHQPFINPFTNYFLSRRNYQVKNQHVESRFVLSNLLNTAFFNNRFSPANTFRPFGRLSVRQPLLDSCLTASGDSGICAPGSVCSLFGGRPSGSCSLGKTCCINAINTCGATVTLNNTYWQSPSVAVNAPTICALNIKLDNNFVEQLGKPICQIRLDFVSFTIAQPTGGTCTDTFQVGGATTVAPITCGDNSGQHMYLDVPSSDVTSTDVQLMFNFATGTATPSSRSWNIKISLLPCGADYLAPVDCLQYFTAPTGRVSSFNWRDVPVSAIRQLNNQNYNICFRTELIDRQGYCTYDYLGIGSATDSATGLMGDRFCGEKLNTARAPGFNSSIQLCTKSKPFKVTFVTDGTEAAVVAPALVMVPADTNNVGFCLDYQERAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDH1</accession>
    <name>E9HDH1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAC3_GANP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_13857</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732624">
        <property type="protein sequence ID" value="EFX70140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70140"/>
    <dbReference type="EnsemblMetazoa" id="EFX70140">
        <property type="protein sequence ID" value="EFX70140"/>
        <property type="gene ID" value="DAPPUDRAFT_13857"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_13857"/>
    <dbReference type="eggNOG" id="KOG1860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047746_2_0_1"/>
    <dbReference type="InParanoid" id="E9HDH1"/>
    <dbReference type="OMA" id="IFTHAYN"/>
    <dbReference type="OrthoDB" id="1593971at2759"/>
    <dbReference type="PhylomeDB" id="E9HDH1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="PTHR12436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3_GANP" evidence="1">
        <location>
            <begin position="8"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="343" mass="40531" checksum="BA66B1EEDB9C2DA8" modified="2011-04-05" version="1" fragment="single">LSGTCLDMCPEKERYSRAEKHRLALYEMLVSPEKMEYDVDHRLAVKEYSRSSADQAEPLAHELRPLPVLQMTMDYLIAKIVDRCNKPGENLGDWFNFLWDRMRGIRKDITQQSLCEKGSVDLVEKCARFHIHCTSRLCELDMQDFDQKINDENLTKCLQTLKHMYYDLSVKNIYCPNEAEFRSYDVLLHLNDGEILREVLQLRSEIRDSYEVRSALEFVNTLNSRNYVRFFKLARSNRDYLQCCLLQRYFNQMRNQAFQIMVQAYGPPKKGQMKLFSLINLLGYEDEEEAAIWCYYHGLPLDPQKKTVKFDRTSFIELPEKFPPMRRSSLIENKRTSSVSNCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDJ7</accession>
    <name>E9HDJ7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">[Heparan sulfate]-glucosamine N-sulfotransferase</fullName>
            <ecNumber evidence="5">2.8.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DAPPUDRAFT_61590</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; heparin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sulfotransferase 1 family. NDST subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.8" evidence="5"/>
    <dbReference type="EMBL" id="GL732624">
        <property type="protein sequence ID" value="EFX70155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70155"/>
    <dbReference type="EnsemblMetazoa" id="EFX70155">
        <property type="protein sequence ID" value="EFX70155"/>
        <property type="gene ID" value="DAPPUDRAFT_61590"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_61590"/>
    <dbReference type="eggNOG" id="KOG3703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011357_2_0_1"/>
    <dbReference type="InParanoid" id="E9HDJ7"/>
    <dbReference type="OMA" id="EMHLNYA"/>
    <dbReference type="OrthoDB" id="388292at2759"/>
    <dbReference type="PhylomeDB" id="E9HDJ7"/>
    <dbReference type="UniPathway" id="UPA00756"/>
    <dbReference type="UniPathway" id="UPA00862"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015016">
        <property type="term" value="F:[heparan sulfate]-glucosamine N-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015014">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030210">
        <property type="term" value="P:heparin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021930">
        <property type="entry name" value="Heparan_SO4_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="PTHR10605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12062">
        <property type="entry name" value="HSNSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HSNSD" evidence="13">
        <location>
            <begin position="7"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransfer_1" evidence="12">
        <location>
            <begin position="496"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFX70155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="785" mass="90691" checksum="F8E96683D213AC92" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDS4</accession>
    <name>E9HDS4_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_257532</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX70075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_257532"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2576233_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="81" mass="8665" checksum="FF0C7F81BF4ED165" modified="2011-04-05" version="1">MRELAHAAADHLHQMVLTMIAEAGVPWSDDAHAHAVDLAQSKGPVPAPSIPDRGPNQSISQVITHTEILADQFYVASTLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDZ3</accession>
    <name>E9HDZ3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_257650</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX70045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70045">
        <property type="protein sequence ID" value="EFX70045"/>
        <property type="gene ID" value="DAPPUDRAFT_257650"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_257650"/>
    <dbReference type="HOGENOM" id="CLU_2724750_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="72" mass="8180" checksum="A146427DB21F2631" modified="2011-04-05" version="1">MRPTLNIQMKSNMAVAGPSQTAGVSNICANYEDLLADFHMQEMERFRNPVTAFSYRFKGQSKEEYIVGPKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9HE90</accession>
    <name>E9HE90_DAPPU</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
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                <person name="Andrews J."/>
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                <person name="Bork P."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Krijgsveld J."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
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                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Rechtsteiner A."/>
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                <person name="Salamov A."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX68719.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="221" mass="24812" checksum="FB993DD4D938D67A" modified="2011-04-05" version="1">MAQPKNMRVEVSMPFEKLMEFMDYMDRISAHVETIEKDSETTKPVQECATACVCNDTFGMLAAKRNFHAYIQNLSPNLVKHLEDFLEFAESENFAPFDRELAENEEIIATQVAIPTFLADVFEAVAGAVITDSNLSFETLEKVFVPFMNSVYDTPPISPFNQLEKTPGISFQKGKARPDGRPTFSVYQNGVLLATGIDENRKNAKFAASKYAAWKIEMGLN</sequence>
</entry>
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    <accession>E9HM23</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_115635</name>
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        <name type="scientific">Daphnia pulex</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX67159.1"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241875" evidence="1">
        <location>
            <begin position="23"/>
            <end position="396"/>
        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX67159.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="396" mass="43457" checksum="7BCAD232AEF4C87D" modified="2011-04-05" version="1">MQISSTLIVCWAGILLIGSVEAFFKKDFGRDATSFVTSVSTVTVTSTEKSICAKLVNVTAACRRRRNFEFERPEILTFDEDIDEAVDLAFRNSFYHKQFAPTKTLSMEVTPLAMLPHSGRLPSNLYPGLGSSYPMYSSSSRNKSPVIHPSLYQEEAKLQQQRQLQQQQQRIFFSALSLANLFNKGTVTFTTFKTETKTKVKTSQATFFVRRQGSSSPAFASVQWAAVERTIVEPSGDEMSQGEEMEVKLYAISKANGLLCKKRQTGSIQRELRIDSPCTDHLFLPPQSDPAVDEEIECEDGYAGLDGLVVLLDDSTHHGGTPVGTPEMDRAFGAPLTAAELASVPTFSKAGCVVHHHHFSSVLTNQRDNHSFVSSGIKFKANRCHGKPEGGGGGVG</sequence>
</entry>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EFX67052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="134" mass="14500" checksum="67CE7E2D8D3EA2C7" modified="2011-04-05" version="1">MVIRYYVSRCLADALQAQMLSGNIRKEIEIPPIPFSNNAGSVIASPAISASPSSLLTATPVFNSPKKPLGGTENPIQLILKGNSLFSHQPLSPIELKDINAVLEQNRQATLSEEGEDVPSSSAENVKWRVLYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9HMU6</accession>
    <name>E9HMU6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein KLF2C</fullName>
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    <gene>
        <name evidence="4" type="primary">KLF2C</name>
        <name evidence="4" type="ORF">DAPPUDRAFT_262353</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732690">
        <property type="protein sequence ID" value="EFX66946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66946"/>
    <dbReference type="EnsemblMetazoa" id="EFX66946">
        <property type="protein sequence ID" value="EFX66946"/>
        <property type="gene ID" value="DAPPUDRAFT_262353"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_262353"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_848005_0_0_1"/>
    <dbReference type="InParanoid" id="E9HMU6"/>
    <dbReference type="OrthoDB" id="1591573at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="269"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX66946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="328" mass="36130" checksum="16CCA8A62120767C" modified="2011-04-05" version="1">MASVSPASSSSSSGLLSGGLSVVPSPAEPVGDRWRRRLSEVDRDLWAADGKFKSSPFGSRQQDGRQRIDQQSVTVAERQQQQQRELRQIRPPSSPSVGLPPLTITYHHRSVAVPLAHHANSLHHQHQGAPRLFTWRLAGSPSITRRLLISPPPSGARRQGVRLDATLFAPGRCSSGDAQLRRSSSQSTPIESASSSSASHPYITHSATATATSDAGQQAGPSVKAKRGRKRWGRKKVTHLCSFAGCAKTYTKSSHLKAHLRTHTGEKPYQCSWKGCGWIFARSHELTRHYRKHTGDRPFQCRLCERAFSRFDHLAPCLALHMKRHVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E9HP85</accession>
    <name>E9HP85_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_116436</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; sulfate assimilation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732704">
        <property type="protein sequence ID" value="EFX66429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66429"/>
    <dbReference type="EnsemblMetazoa" id="EFX66429">
        <property type="protein sequence ID" value="EFX66429"/>
        <property type="gene ID" value="DAPPUDRAFT_116436"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_116436"/>
    <dbReference type="eggNOG" id="KOG4238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009463_3_0_1"/>
    <dbReference type="InParanoid" id="E9HP85"/>
    <dbReference type="OMA" id="ESQCKKV"/>
    <dbReference type="OrthoDB" id="528280at2759"/>
    <dbReference type="PhylomeDB" id="E9HP85"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050428">
        <property type="term" value="P:3'-phosphoadenosine 5'-phosphosulfate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_2" evidence="9">
        <location>
            <begin position="190"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase" evidence="8">
        <location>
            <begin position="350"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX66429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="582" mass="65004" checksum="7D0CF8CFEF75CCCE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPY3</accession>
    <name>E9HPY3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_302906</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LanC-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732712">
        <property type="protein sequence ID" value="EFX66197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66197"/>
    <dbReference type="EnsemblMetazoa" id="EFX66197">
        <property type="protein sequence ID" value="EFX66197"/>
        <property type="gene ID" value="DAPPUDRAFT_302906"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302906"/>
    <dbReference type="eggNOG" id="KOG2787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036244_0_0_1"/>
    <dbReference type="InParanoid" id="E9HPY3"/>
    <dbReference type="OMA" id="MAGTIHF"/>
    <dbReference type="OrthoDB" id="681208at2759"/>
    <dbReference type="PhylomeDB" id="E9HPY3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020464">
        <property type="entry name" value="LanC-like_prot_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01951">
        <property type="entry name" value="LANCEUKARYTE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX66197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="427" mass="48399" checksum="145410430C1DC7D7" modified="2011-04-05" version="1">MNTWSLVKKDDRHFINPFLVPGKQLNFDPKNEEFTKHLKAVTNKLLLQWEKNVKAEIDYTGSTNWDDSSIYTGTSGYALLYFEAGKILNSAEYLEQAFFMAEKCTMHLHKPNVKSLTFLTGAGGPLALSAVCAHFLKQPEKEHHFIHRLQSVYHSFEVVTNSSSGLPDELLYGRAGCLYALLFMKQYCKEKVDGDLIVHIAEAIIESGKRLAKELQHKGHKTPPLMFEWHEQKYLGPAHGFAGILYLLMQVKDYLEPGVLENYIRPCLDFLLDVRFPSGNIPSSMGSDRDRLVQWCHGAPGFIHCFVVAAKVFHSDVYLKAAKQCADVTWERGILTKGFSICHGISGNALAILHLYKHTNDLVYLQRACQLAEIVMDDRPHEFRTPDRPLSMFEGMAGVIFFLLNLLDPEKSDCSFPGYQINSFDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9HS18</accession>
    <name>E9HS18_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_189667</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732744">
        <property type="protein sequence ID" value="EFX65437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX65437"/>
    <dbReference type="EnsemblMetazoa" id="EFX65437">
        <property type="protein sequence ID" value="EFX65437"/>
        <property type="gene ID" value="DAPPUDRAFT_189667"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_189667"/>
    <dbReference type="eggNOG" id="KOG0934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_1_3_1"/>
    <dbReference type="InParanoid" id="E9HS18"/>
    <dbReference type="OMA" id="KAYHILD"/>
    <dbReference type="OrthoDB" id="1307450at2759"/>
    <dbReference type="PhylomeDB" id="E9HS18"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="PTHR11753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SSF64356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clat_adaptor_s" evidence="9">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX65437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="157" mass="18449" checksum="BC81228CB2ACA648" modified="2011-04-05" version="1">MMQFMLLFSRQGKLRLQKWYSAQPDKTKKKITRDLVATILTRKPKMCSFLEWRELKIVYKRYASLYFCCAIEQSDNELLTLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFMLDELMLGGEVQETSKKNVLKAIAAQDLLQEDEAVEGALREIGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9HT92</accession>
    <name>E9HT92_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_231870</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732766">
        <property type="protein sequence ID" value="EFX65051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65051">
        <property type="protein sequence ID" value="EFX65051"/>
        <property type="gene ID" value="DAPPUDRAFT_231870"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_231870"/>
    <dbReference type="eggNOG" id="ENOG502S6ZF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166294_1_0_1"/>
    <dbReference type="InParanoid" id="E9HT92"/>
    <dbReference type="OMA" id="QSACNIG"/>
    <dbReference type="OrthoDB" id="1633908at2759"/>
    <dbReference type="PhylomeDB" id="E9HT92"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003238336" evidence="1">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="84" mass="8002" checksum="7CFB70CD671A8E78" modified="2011-04-05" version="1">MKSTVAVCYILVALLPLMAVAGPLAYGICQTGCNAAVVACYTAGGATFGTVTAGVGVPAVIMGCNAALGVCMAGCVAAGFAPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HT99</accession>
    <name>E9HT99_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_265342</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732768">
        <property type="protein sequence ID" value="EFX65018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65018">
        <property type="protein sequence ID" value="EFX65018"/>
        <property type="gene ID" value="DAPPUDRAFT_265342"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2443062_0_0_1"/>
    <dbReference type="InParanoid" id="E9HT99"/>
    <dbReference type="OrthoDB" id="222689at2759"/>
    <dbReference type="PhylomeDB" id="E9HT99"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX65018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="90" mass="10276" checksum="162D5A87D3640AC9" modified="2011-04-05" version="1">MRAVLESRSVTDEVLRTVFAEVASLLNSRPLTNVQTDPSEPEPLTPYHFILGTPHPHRAPDTEEAFDGLNRAEMQRFPYTFFLSTIILIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9HTC9</accession>
    <name>E9HTC9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_117648</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732770">
        <property type="protein sequence ID" value="EFX65003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65003">
        <property type="protein sequence ID" value="EFX65003"/>
        <property type="gene ID" value="DAPPUDRAFT_117648"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_117648"/>
    <dbReference type="HOGENOM" id="CLU_987850_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HTC9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035064">
        <property type="term" value="F:methylated histone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042778">
        <property type="entry name" value="ZCWPW1/ZCWPW2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15999">
        <property type="entry name" value="PTHR15999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="282" mass="32397" checksum="3113FCB724A56D65" modified="2011-04-05" version="1">MISFTASGIATLVNLRLSNCIFYCCVKTQHTNILLQQLWWTGYQGRNFGYGYTSVSAVMWKLWVRVWNQASALLWKMNFWQQVTALARTIFTWVVPSVVPKETIWSAKMPRNSIPSVTNPPAEKWVELRRQFSEGVWTYGEAFFDFFHVKKCIERNNEETPLLCAVENISPDGTDLEPLTFDMKDAQGSAQHRLAINKPLPANWQSEKHDRTLFQRDTKQDENNKVPAYLEHYSVVQLTQKTAKKKKKLSSDLRSSWKLREAVGSADEDSDGISEETGHIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9HU00</accession>
    <name>E9HU00_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_117865</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732792">
        <property type="protein sequence ID" value="EFX64780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX64780"/>
    <dbReference type="EnsemblMetazoa" id="EFX64780">
        <property type="protein sequence ID" value="EFX64780"/>
        <property type="gene ID" value="DAPPUDRAFT_117865"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_117865"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_991308_0_0_1"/>
    <dbReference type="InParanoid" id="E9HU00"/>
    <dbReference type="OrthoDB" id="772297at2759"/>
    <dbReference type="PhylomeDB" id="E9HU00"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070413">
        <property type="term" value="P:trehalose metabolism in response to stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX64780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="281" mass="31315" checksum="4CBBBD71CBB75990" modified="2011-04-05" version="1">MIPLDRVLGGAGPASWWSWTSGLVELGQDLDAPADHCWRGGDIRLRGPLHMVGFHIDDYCTNFIKCCQRRLGCRVDHANGNVEYDNRTVHVRPLPIGIPFIISSSWPLKHLERTSRVGSGLTRLHKRIGPTHQSVRKAAGASLHPEHLERVVLMQIAVPSRTDVREYKALKEEIDQLVGRINGRFSTAEWSPIRYIYGCILHDNLAAFYSDSAVALVTPLRDGMNLVAKEFVACQINKTGVLILSPFAGAGGTMREALLVNPYEVDMVSEMIHKGLDYGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9HV32</accession>
    <name>E9HV32_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_334239</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732836">
        <property type="protein sequence ID" value="EFX64398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX64398"/>
    <dbReference type="EnsemblMetazoa" id="EFX64398">
        <property type="protein sequence ID" value="EFX64398"/>
        <property type="gene ID" value="DAPPUDRAFT_334239"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_334239"/>
    <dbReference type="HOGENOM" id="CLU_025842_0_0_1"/>
    <dbReference type="InParanoid" id="E9HV32"/>
    <dbReference type="PhylomeDB" id="E9HV32"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048583">
        <property type="term" value="P:regulation of response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR026741">
        <property type="entry name" value="SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039187">
        <property type="entry name" value="SNO_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706">
        <property type="entry name" value="PTHR12706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13872">
        <property type="entry name" value="AAA_34"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="57"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX64398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="286" mass="32486" checksum="DF4459FC9D7F066B" modified="2011-04-05" version="1" fragment="single">MEEEHPSPVVESIYLRTVSLPDIVYQLPLPQVTIDSGVLSSLQLKSIIYACQRHEQKTPDGSRGGYLVGDGTGFGKGRIAAGIIFVNHLHGRKKAVWLSMHRDLQYDAERDLRDVADTQVTIFNLKKLNLLSADENGVAFSTYSTLTEEFHVNNKKSTRLQQLLEWCGPDYDGVIVFDECHHTNLLDLSGTKILFSLLELQTKLPNARIIYMSVTGVSSDLRNMAFMSRLGLWGLGTSFPDFKDFHQTLEKDGLHSREMMAMELKLRGMYLARRMDLKDVKFRMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HVP1</accession>
    <name>E9HVP1_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_118421</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732864">
        <property type="protein sequence ID" value="EFX64189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64189">
        <property type="protein sequence ID" value="EFX64189"/>
        <property type="gene ID" value="DAPPUDRAFT_118421"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_118421"/>
    <dbReference type="HOGENOM" id="CLU_1027657_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HVP1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX64189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="271" mass="30200" checksum="F8195181E51F06D8" modified="2011-04-05" version="1">MERSRRCNASVPAKRFTPEQSTKSRRPGKSIPEEPVYTKDIMNDSENSRDSDDSKSIDSGAKQSPLNDQSLTSRSSSSSSIDTLGRGFGRGRGRPLSQETPKTGRIASPTRPINPSGCASLHLRRIDTAVVGKKIQRSSMPLDVEEAGMDEGAVGGFAEVASKRPRVDEEVREGHQSRTNSAASELQLLNQEKYCRMIAATYTNSQEMLRRQGDMALKINILTDYVAKLRVDADESSQKNQRMTAVDDLIEKFPLNELSDFDNFERRLKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9HWR0</accession>
    <name>E9HWR0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_334956</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732951">
        <property type="protein sequence ID" value="EFX63823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63823">
        <property type="protein sequence ID" value="EFX63823"/>
        <property type="gene ID" value="DAPPUDRAFT_334956"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_334956"/>
    <dbReference type="eggNOG" id="ENOG502SD1W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002013_0_0_1"/>
    <dbReference type="InParanoid" id="E9HWR0"/>
    <dbReference type="OrthoDB" id="88836at2759"/>
    <dbReference type="PhylomeDB" id="E9HWR0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="716"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX63823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1926" mass="224045" checksum="C3939636C125E258" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HXE5</accession>
    <name>E9HXE5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_268203</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733034">
        <property type="protein sequence ID" value="EFX63585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63585">
        <property type="protein sequence ID" value="EFX63585"/>
        <property type="gene ID" value="DAPPUDRAFT_268203"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_268203"/>
    <dbReference type="HOGENOM" id="CLU_1847167_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX63585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="139" mass="16312" checksum="88D1A185A06969FA" modified="2011-04-05" version="1">MPLWRNWLARSAVNRKAGGSIPPRGACVGCTLMMFFLCPELLFQVQNNDKRTEKNEFLSKMKVKYTVQMLSNSVANGFWYFRSTESTEEMVLKWNNLLYVMNGRSKVLETFLEDIPGKRSLHVIQQAFFLFVRKLPWKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9HXJ3</accession>
    <name>E9HXJ3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gb3_synth domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_67050</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL733045">
        <property type="protein sequence ID" value="EFX63533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX63533"/>
    <dbReference type="EnsemblMetazoa" id="EFX63533">
        <property type="protein sequence ID" value="EFX63533"/>
        <property type="gene ID" value="DAPPUDRAFT_67050"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_67050"/>
    <dbReference type="HOGENOM" id="CLU_049512_0_0_1"/>
    <dbReference type="InParanoid" id="E9HXJ3"/>
    <dbReference type="OrthoDB" id="162604at2759"/>
    <dbReference type="PhylomeDB" id="E9HXJ3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007652">
        <property type="entry name" value="A1-4-GlycosylTfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04572">
        <property type="entry name" value="Gb3_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gb3_synth" evidence="2">
        <location>
            <begin position="179"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX63533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="281" mass="33071" checksum="626EB58DC273469E" modified="2011-04-05" version="1" fragment="single">MEQKFNIVRYSDIVNVKGLNQSSSFHSISLLSDDKRIYFHETTGRDHLNLRQLCAVESTAKENSNRSVQMFFQSNHVNLTVGPLAHILEKYPNIFVILIDVRDYFNQTPLEDWYLRGAWRQSPYKTEHFSDYIRILSSYKGGGMYMDLDFVALKPFDDNIFWNFVPEEDDSVLTGSSFHFQKDHPIVRKMMTYLASSYHPKEWSYSGPAMFQSVVLKFCQRRAPLPTYPVFLCPDIRVLPKTYLYPYKFAEWKRMFRFSNVSGDDAIFQSYAVHTYNKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9HY04</accession>
    <name>E9HY04_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_67139</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733093">
        <property type="protein sequence ID" value="EFX63378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX63378"/>
    <dbReference type="EnsemblMetazoa" id="EFX63378">
        <property type="protein sequence ID" value="EFX63378"/>
        <property type="gene ID" value="DAPPUDRAFT_67139"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_67139"/>
    <dbReference type="eggNOG" id="KOG1987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004253_9_3_1"/>
    <dbReference type="InParanoid" id="E9HY04"/>
    <dbReference type="OMA" id="NACISFF"/>
    <dbReference type="OrthoDB" id="864323at2759"/>
    <dbReference type="PhylomeDB" id="E9HY04"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="SSF54695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="120" mass="14071" checksum="BDAECE7CF536C854" modified="2011-04-05" version="1" fragment="single">NQVVIEDIQPEVFHQLIRFIYTGRLTSTTMETMAARLFAAADKYLLDQLKSECESHLLRQMSAENCMELLLLSSDQIHPADELKKNAMDFFRRYPREVMATEGWKKARQENPNHSIWNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9HYL0</accession>
    <name>E9HYL0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_229930</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733186">
        <property type="protein sequence ID" value="EFX63172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63172">
        <property type="protein sequence ID" value="EFX63172"/>
        <property type="gene ID" value="DAPPUDRAFT_229930"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_229930"/>
    <dbReference type="HOGENOM" id="CLU_543219_0_0_1"/>
    <dbReference type="OrthoDB" id="1205089at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="SSF49842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C1q" evidence="2">
        <location>
            <begin position="353"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX63172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="502" mass="55470" checksum="39E6735D98540089" modified="2011-04-05" version="1">MNELLTMIIDDEFNHPLNSIIQYRKRLDAIATDFSGPTVASTTRPSTVSAAAAVNATAVPTETTTTTTITTTTEKVTTTTAAATDSTSGVILQSQSTADSTENGSIENPNLIMTFIEENVNELEKFIDVAKNEMNELLTMIIDDEFNHPLNSIIQYRKRLDAIATDFSGPTVAQNITTTSTTRPSTVSAAAVPTETTTTTTITTTTEKVTTTTAAATDSTSGVILQSQSTADSTENGSIENPNLIMTFIEEAVNELDKSIDVAKNEMNELNHTLNSIIQYRKRLDAIATDLEKKVFEDGKFLRDIEDQIKQMDIIEKELDIKEAMLLALNGRETLLGNKIEHNLNLYNNPSVLDSWKISFFAQRNGTFNIKTVIHPFDIVPLNQGQCFSPSSGVFTVPFHGIYHFYFAALKMKKQESGTGRVTIQLVKNRKIVPTLRKVLAEVHLDSADWYGWFPLHLQATVDLQEMDEITAELLEGSLYDSGSPDHLLTDFGGFLITRLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZY9</accession>
    <name>E9HZY9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_336585</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733435">
        <property type="protein sequence ID" value="EFX62692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62692">
        <property type="protein sequence ID" value="EFX62692"/>
        <property type="gene ID" value="DAPPUDRAFT_336585"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_336585"/>
    <dbReference type="HOGENOM" id="CLU_2707283_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX62692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="73" mass="8459" checksum="06AD1ECD024D6614" modified="2011-04-05" version="1">MKMLVAFVAIAAAADGHDYFPSYKTTRRIQILLRLNYSIPAYRKQCLNLITRLVVTILSNTLFSVYTYVDEWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9I0T0</accession>
    <name>E9I0T0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cir_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_270484</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733621">
        <property type="protein sequence ID" value="EFX62400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX62400"/>
    <dbReference type="EnsemblMetazoa" id="EFX62400">
        <property type="protein sequence ID" value="EFX62400"/>
        <property type="gene ID" value="DAPPUDRAFT_270484"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_270484"/>
    <dbReference type="eggNOG" id="KOG3794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116345_0_0_1"/>
    <dbReference type="InParanoid" id="E9I0T0"/>
    <dbReference type="OMA" id="WGHINTG"/>
    <dbReference type="OrthoDB" id="1604301at2759"/>
    <dbReference type="PhylomeDB" id="E9I0T0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040014">
        <property type="entry name" value="CIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13151">
        <property type="entry name" value="PTHR13151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cir_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX62400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="167" mass="19976" checksum="9E2B5FAAF28B8D75" modified="2011-04-05" version="1">MGKGFNNYMCKKFFHPGSRDNLKRVWMAQQKTDAEKKKQEELKAQYEKEQDLYVNKSLVSKESKEKLSVNFLYEPPPGMKKEREKEDGEPEFKFEWQRKYNAPREDYCRGDEDIRDQPFGIAVRNVRCIKCHKWGHLVVQKESLRQLFLVLVWSEDELINKVPLLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9I217</accession>
    <name>E9I217_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_271388</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733953">
        <property type="protein sequence ID" value="EFX61963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX61963"/>
    <dbReference type="EnsemblMetazoa" id="EFX61963">
        <property type="protein sequence ID" value="EFX61963"/>
        <property type="gene ID" value="DAPPUDRAFT_271388"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_271388"/>
    <dbReference type="eggNOG" id="KOG1943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533475_0_0_1"/>
    <dbReference type="InParanoid" id="E9I217"/>
    <dbReference type="OrthoDB" id="79003at2759"/>
    <dbReference type="PhylomeDB" id="E9I217"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034333">
        <property type="term" value="P:adherens junction assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="PTHR12658"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="511" mass="57592" checksum="3EA09A8F033B9A73" modified="2011-04-05" version="1">MTLEVADECTQKEIDVIGLGCLKESFTEHSEVEKLIDELRTSAQHQTNQTDIQEVLDYEVKHVAFRCLYFISKVRGYKVVAIHLPHETADLEPLLHYLENQDPGVQLKWETHYSLLLWLSLVVKIPFHLQRFDTSTSEPIMGGLMSKIPIYRDSSIGLMSLFVAQYEEYRPHLIQHLVDRKVIHWHTLIRQLTSQALHQMTFLDPESMKLILSTQILPRCTNPELYLRHGSILASGKVISALCQVAKDHQRRLPDELGDAAMESITQTCIDILEARFWRSFGGDPMRIAVCHFIQDFSSGGFPLLDAVVDRWLKALRECLASADSNVQQSAISAVTASIGEYFRHQPVEKLTTLLNHFLPEVTSNNQQARVGNALALGSMPRFLLTVSLPKVIQQLCTCALITDKTLQWAESRKNALKALSLVCTTVGIAPSSPVKMTDGLIFIYFEISGVDQVTLAGIFRTFIDGFEDYTVDSRGDIGAIVRESAMYSIQVLTNTSQPELLEADLIRSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2H4</accession>
    <name>E9I2H4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_338069</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL734103">
        <property type="protein sequence ID" value="EFX61806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61806">
        <property type="protein sequence ID" value="EFX61806"/>
        <property type="gene ID" value="DAPPUDRAFT_338069"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_338069"/>
    <dbReference type="eggNOG" id="ENOG502QTS0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498391_0_0_1"/>
    <dbReference type="InParanoid" id="E9I2H4"/>
    <dbReference type="OrthoDB" id="1209400at2759"/>
    <dbReference type="PhylomeDB" id="E9I2H4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="31"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX61806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="547" mass="61249" checksum="BB6804215AD21D7E" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2N6</accession>
    <name>E9I2N6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_271998</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734178">
        <property type="protein sequence ID" value="EFX61745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61745">
        <property type="protein sequence ID" value="EFX61745"/>
        <property type="gene ID" value="DAPPUDRAFT_271998"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_271998"/>
    <dbReference type="HOGENOM" id="CLU_1847138_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9I2N6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="139" mass="16097" checksum="1A3267881B470167" modified="2011-04-05" version="1">MGNHPASAWFHNSLQHLSHSWHRFNKFGISRDKKADRCSAWFVDQADNNNKPLPFFSFARRTISEESIDFFDRFSKINKRANTQRIPAGRRGQQPNDNVVEEAFARADRINQLDRQRGAKSSSIERWIGGSRPIRGLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9I3X3</accession>
    <name>E9I3X3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_340198</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734800">
        <property type="protein sequence ID" value="EFX61307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX61307"/>
    <dbReference type="EnsemblMetazoa" id="EFX61307">
        <property type="protein sequence ID" value="EFX61307"/>
        <property type="gene ID" value="DAPPUDRAFT_340198"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_340198"/>
    <dbReference type="eggNOG" id="KOG2158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2661550_0_0_1"/>
    <dbReference type="OrthoDB" id="214376at6656"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="76" mass="8875" checksum="C39B9B04446DF28B" modified="2011-04-05" version="1" fragment="single">MTILSRKNNLGTALMNFRKQFPGEYEFFPITWSLPNDYQDLLAYHDCRQQGKAQTFIVKPEASCQGRGIYLTRNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9I513</accession>
    <name>E9I513_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CLP1_P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_122726</name>
    </gene>
    <organism evidence="3">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90340"/>
    <dbReference type="EnsemblMetazoa" id="EFX90340">
        <property type="protein sequence ID" value="EFX90340"/>
        <property type="gene ID" value="DAPPUDRAFT_299863"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299863"/>
    <dbReference type="eggNOG" id="ENOG502QTMZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054217_0_0_1"/>
    <dbReference type="InParanoid" id="E9FQM4"/>
    <dbReference type="OMA" id="YVTKQHA"/>
    <dbReference type="OrthoDB" id="1586037at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:I-kappaB kinase/NF-kappaB signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="PTHR15263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX90340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="364" mass="42380" checksum="289F3EA277008891" modified="2011-04-05" version="1">MSSKTKKRFDRLISCVKSNNVERLKHYARRKKYAKLHLDEIGVNKKGETLLHLACRQGKHEIVAFLLENSLGDPTSMDCKGNTPLHLALKAIMKIDERNEYLTAYRKMILAHLKEMAVSLTQPNLEGQTAKDLLDLADSVYEYHLGGNEKKTEFSQQKDEQEWQKKLSAELDDEYGSHWGKYEEDFVQEDVNETESYDSWAKRMINEHKKKMSSQKFHITPPSPPKLKPSWSTEDQQQFLRDEEMRNVFRKKAKATQKLTTFLTKLSLLIQTEDQIKISDLPFKPTDDVESIGQLILAHVKDLVDPDAKRKALRELQRLWHPDKFSQKFGVRLKEEIRENVLKKVTEISQYLNAFNCVSTVTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9FQZ5</accession>
    <name>E9FQZ5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Coenzyme Q biosynthesis protein 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_230099</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COQ4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90069"/>
    <dbReference type="EnsemblMetazoa" id="EFX90069">
        <property type="protein sequence ID" value="EFX90069"/>
        <property type="gene ID" value="DAPPUDRAFT_230099"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230099"/>
    <dbReference type="eggNOG" id="KOG3244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061241_1_1_1"/>
    <dbReference type="InParanoid" id="E9FQZ5"/>
    <dbReference type="OMA" id="PWVVEQA"/>
    <dbReference type="OrthoDB" id="1264469at2759"/>
    <dbReference type="PhylomeDB" id="E9FQZ5"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="PTHR12922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX90069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="235" mass="26521" checksum="906D1C10EE654C39" modified="2011-04-05" version="1">MKSETTKKSEPLYDGHIPINLLQRAVLSVGSSIVALTDPARGDMVAVNGESSGHSALKKMHRKMLESEEGRQILMERPRINSTTIDIEKLKSYPDGTLGREYTKFLEVNNVSPDTRLPVRFVDDADLAYVMQRYRETHDLVHTLLGCPTNMLGEVAVKWVEALQTELPMCIGGAVFGPIRLKPKNRSTYLSKYLPWAIGVGSRSSFLMNVFYERRWEQDIAELRDELKIETPPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9FQZ9</accession>
    <name>E9FQZ9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_232463</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX90072">
        <property type="protein sequence ID" value="EFX90072"/>
        <property type="gene ID" value="DAPPUDRAFT_232463"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_232463"/>
    <dbReference type="HOGENOM" id="CLU_2348757_0_0_1"/>
    <dbReference type="OrthoDB" id="1856044at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX90072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="97" mass="10943" checksum="1CF572E47DF419D5" modified="2011-04-05" version="1">MDHKDHHHHTVAHGKKGHEHTDSKHQAEENQAPRAGFQLGQTAAGFGTNKTSELSTFANTKDFEDLEAESRSNSGHEHEEHGEHDHEDDKEDHHAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9FR88</accession>
    <name>E9FR88_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Brain protein I3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_309949</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BRI3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX90120">
        <property type="protein sequence ID" value="EFX90120"/>
        <property type="gene ID" value="DAPPUDRAFT_309949"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309949"/>
    <dbReference type="HOGENOM" id="CLU_138141_0_0_1"/>
    <dbReference type="InParanoid" id="E9FR88"/>
    <dbReference type="OrthoDB" id="1809785at2759"/>
    <dbReference type="PhylomeDB" id="E9FR88"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019317">
        <property type="entry name" value="Brain_I3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13551">
        <property type="entry name" value="PTHR13551"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10164">
        <property type="entry name" value="DUF2367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX90120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="106" mass="11203" checksum="67F6152475B3E83F" modified="2011-04-05" version="1">MEKGNPPPYAPSAPPPGFIMQEEQKCYPALPVADPAPTVIHVGNQQAAPPQVIVVGGGCPKCHVGSIQTSHITCCGILWAILLFPVGLLCLLCCTKKRCTNCSYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSK8</accession>
    <name>E9FSK8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 208</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">EOG090X0IGL</name>
        <name evidence="12" type="ORF">DAPPUDRAFT_190457</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TCO</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMEM208 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015622">
        <property type="protein sequence ID" value="SVE85241.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89811"/>
    <dbReference type="EnsemblMetazoa" id="EFX89811">
        <property type="protein sequence ID" value="EFX89811"/>
        <property type="gene ID" value="DAPPUDRAFT_190457"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_190457"/>
    <dbReference type="eggNOG" id="KOG3269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094308_3_0_1"/>
    <dbReference type="OMA" id="VFMHILA"/>
    <dbReference type="OrthoDB" id="1407446at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="PTHR13505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX89811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SVE85241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="177" mass="20424" checksum="8E6C3FFACD274268" modified="2011-04-05" version="1">MTAEKKSTKQATKGQKQIVEENVATLNFYRNMSVVAVGVYLLFSAIFWSTTSSFDIFLICLSSFAQFCCYRFMAYMARAKYSETGQLLDGGIDLNMESGISEQIKDAIILVSATEVLSCMSSYFWLILLVIPCRLFHLAWKHFLSPWFFQKAPTAEQDAQDDKKQRKLERRIKRQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSW0</accession>
    <name>E9FSW0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_303133</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89262"/>
    <dbReference type="EnsemblMetazoa" id="EFX89262">
        <property type="protein sequence ID" value="EFX89262"/>
        <property type="gene ID" value="DAPPUDRAFT_303133"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303133"/>
    <dbReference type="eggNOG" id="KOG4280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_22_3_1"/>
    <dbReference type="InParanoid" id="E9FSW0"/>
    <dbReference type="OMA" id="NMRKHIE"/>
    <dbReference type="OrthoDB" id="862274at2759"/>
    <dbReference type="PhylomeDB" id="E9FSW0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008089">
        <property type="term" value="P:anterograde axonal transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="PTHR24115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="9"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="653"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="427"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="663"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="103"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX89262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="687" mass="77724" checksum="8DE50EF6A50F52D6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSZ0</accession>
    <name>E9FSZ0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DpGSTM2</name>
        <name evidence="5" type="ORF">DAPPUDRAFT_205726</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Liu Z."/>
                <person name="Zhang W."/>
                <person name="Zhao Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Mu family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MN730111">
        <property type="protein sequence ID" value="QNM80605.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89275"/>
    <dbReference type="EnsemblMetazoa" id="EFX89275">
        <property type="protein sequence ID" value="EFX89275"/>
        <property type="gene ID" value="DAPPUDRAFT_205726"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_205726"/>
    <dbReference type="eggNOG" id="KOG1695">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039475_2_0_1"/>
    <dbReference type="OMA" id="KWANKRA"/>
    <dbReference type="OrthoDB" id="1162336at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003081">
        <property type="entry name" value="GST_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01267">
        <property type="entry name" value="GSTRNSFRASEM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="88"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX89275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QNM80605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="214" mass="24761" checksum="3A1CBAFEF210A522" modified="2011-04-05" version="1">MPPVLAYWAIRGLAQPIRLLLKYTQTEFEDKRYVVGPGFDKSCWFDVKYSLGLDFPNLPYYVDGDVKLTQSNAILRYIAGKHNLIGTNEKEKIRVDLMENEVGDFRNGWVRLCYSPNFDELKGDYISGLPSKLSEFSKYLGDNNWLAGENISFVDFIFYEMLDQHMILVPDCLDSFLNLKLHCERFRSLDSIKTYISSSEFIARPLNNPHAGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSZ8</accession>
    <name>E9FSZ8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_230152</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89730"/>
    <dbReference type="MEROPS" id="S51.002"/>
    <dbReference type="EnsemblMetazoa" id="EFX89730">
        <property type="protein sequence ID" value="EFX89730"/>
        <property type="gene ID" value="DAPPUDRAFT_230152"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230152"/>
    <dbReference type="eggNOG" id="ENOG502QR7X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071689_0_0_1"/>
    <dbReference type="InParanoid" id="E9FSZ8"/>
    <dbReference type="OMA" id="RDHDKYT"/>
    <dbReference type="OrthoDB" id="1341849at2759"/>
    <dbReference type="PhylomeDB" id="E9FSZ8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03146">
        <property type="entry name" value="GAT1_Peptidase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX89730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="243" mass="27129" checksum="9CF2627985A848BC" modified="2011-04-05" version="1">MRKLLLLSTSVLQNGKYLDYASDVIKAFFAENGVSKIVFIPYAAHDHDAYEKKVKDAFLEFGLELNSIHKSDNLMATVKEAQGFFVGGGNTFLLLKTLYDLNLLEAIKSRVLQDGIPYMGSSAGTNLATVNICTTNDMPIVHPPTLDAFGFLPFNINPHYLDHDPTSKHMGESRETRLSEYHDIPNAKSPPVLGLREGSWLQVKDDQILLKGSISNQTARLFVRGQQTKEHEVNSDLSFLLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUW2</accession>
    <name>E9FUW2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_41191</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88794"/>
    <dbReference type="EnsemblMetazoa" id="EFX88794">
        <property type="protein sequence ID" value="EFX88794"/>
        <property type="gene ID" value="DAPPUDRAFT_41191"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_41191"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_3_0_1"/>
    <dbReference type="InParanoid" id="E9FUW2"/>
    <dbReference type="OMA" id="WVSARYT"/>
    <dbReference type="OrthoDB" id="621852at2759"/>
    <dbReference type="PhylomeDB" id="E9FUW2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX88794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="453" mass="48821" checksum="D1DD105F77B765FF" modified="2011-04-05" version="1" fragment="single">RRKITLANGVAIIVGSIIGSGIFISPKGVLANAGSTGAALVVWALSGIFSAGGALCYAELGTIISRSGGDYAYILEAFGSLPAFLTLWVITLIIKPASQAVVALTFATYMLQPIFGDCPVPYTAVRLLAACCLCLLTSISCASVRGAMRVQNVFTVAKLMALFIVIVLGLAELFAGKTENLTFTPYLEDAPLNIGKLSLAFYSGLFAFGGWNYLNFVIDELQDPYRNLPLAIFIAMPIVTLFYVLANLSYFVVISPTEIIASHAVAVTFGLKLYSWLKWVIPLFVSISTFGSLNGITFTAARIVATGANEGQFPAACGFLHQKLLTPIPALMWECFLALTLLLFPDVFSLINYLSFALWLVSGASVTGLLYLRWKLPDIERPIKVPLVLPVTFLICCIFLVLVPAIVTPLDTGIGVIIVLAGVPVHFLIKKSSSSSTVQKYSGTTFTDFYHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9FV18</accession>
    <name>E9FV18_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_220681</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX89182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89182">
        <property type="protein sequence ID" value="EFX89182"/>
        <property type="gene ID" value="DAPPUDRAFT_220681"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_220681"/>
    <dbReference type="eggNOG" id="ENOG502RYTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_861242_0_0_1"/>
    <dbReference type="InParanoid" id="E9FV18"/>
    <dbReference type="OMA" id="AHYRDAF"/>
    <dbReference type="OrthoDB" id="1399421at2759"/>
    <dbReference type="PhylomeDB" id="E9FV18"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012565042" evidence="2">
        <location>
            <begin position="16"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX89182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="323" mass="35096" checksum="CDE481127928085F" modified="2011-04-05" version="1">MKVLILSFFLACASAQYYPGFYGPGFTSQYHAQDVLGQASYGFSHPGQAAAHYRDAFGNQVGSYAYINPVGKEVMVSYTADSRGFRVASNDLPESPVAPVVLLKSPEPVQETPEVAEAKAKLFALQKEASAKRTKRQVPVYPAALPYTPYTPAFYSGALPAIKHVAPWVAPAPLFTKTTLKTVTAEADPSAKTPADTTKFDLKEKSFDVVTPVAYPYAPYGYTYPFAAPVAAPVEVSRKKRQVTVFPYPSAVYGATFPTPLVAKTTLKTVTAEADPSAKTPADTTKFDLKEKSFDVVTPVAYPYYAPYGYTYPNAYPQVNGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9FVK1</accession>
    <name>E9FVK1_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_40950</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88569"/>
    <dbReference type="EnsemblMetazoa" id="EFX88569">
        <property type="protein sequence ID" value="EFX88569"/>
        <property type="gene ID" value="DAPPUDRAFT_40950"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_40950"/>
    <dbReference type="eggNOG" id="KOG3510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046341_4_2_1"/>
    <dbReference type="InParanoid" id="E9FVK1"/>
    <dbReference type="OMA" id="CTIPHLK"/>
    <dbReference type="OrthoDB" id="1125529at2759"/>
    <dbReference type="PhylomeDB" id="E9FVK1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="PTHR23279"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="27"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="140"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="269" mass="29973" checksum="2F49C025566487EC" modified="2011-04-05" version="1">MNLESSSSSDQQQHKTQDDQILALKGPKFVPEASKNITALAGRVASLNCRIKNLDNWTVSWVRHRDVSLLTVASYTYSSDQRFRAVHKPYFGEQTPLTDTYSDWGLEIHSSQPRDSGIYECQISTTPHRSLFVHLRVVEPSTTVLGGSEVFVGMGSTINLTCVIRLSPEPPNSIRWQHNNQMIGYDSNRGGVSVVTEKGIESSSSLLIQNARPADSGKYVCRPDNAEPATVNVHVLNGKFDPFCYSHVVVCRLFFTLCISYETKNKTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9FW89</accession>
    <name>E9FW89_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_220911</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88968">
        <property type="protein sequence ID" value="EFX88968"/>
        <property type="gene ID" value="DAPPUDRAFT_220911"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_220911"/>
    <dbReference type="HOGENOM" id="CLU_376113_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="738" mass="80204" checksum="5A867247C3F95F91" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9FWV1</accession>
    <name>E9FWV1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX87959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX87959">
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        <property type="gene ID" value="DAPPUDRAFT_234539"/>
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    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_234539"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
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    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="8">Sugar transporter SWEET</fullName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="8">Mediates sugar transport across membranes.</text>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="313" mass="33160" checksum="42FC7C6428754824" modified="2011-04-05" version="1">MDEQESSTTVVTSSSTSQSSSSSSTSYSSSSSTTLVQQTLMTITDDGELAVDEPISDVIGREAVITSSTTTSSSSTTAATTSSSSQLVVEDGVTSAVRMEEETTVVSSSSGLSVSQHHQEATVTTTQEALNSPSALLDEEEQLLAQELLLEAAEETFSCGAAFTTEAEAPSIEMAEDLKEPGNDDGGDSGVGTEINTSAVDVVQQQEQEILEREAAATHEVGEEDSSIRQEPRLSTLVEEAVASGSECRPVENLDLSVPLSTSLSSSSHSNREIQQENIKHALHEIISEIDREMEADLSNEEVSSVMLSHWEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZC9</accession>
    <name>E9FZC9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_43798</name>
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    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
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                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RHPN family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87285"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_43798"/>
    <dbReference type="eggNOG" id="KOG2220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006514_1_0_1"/>
    <dbReference type="InParanoid" id="E9FZC9"/>
    <dbReference type="OMA" id="THPDFGQ"/>
    <dbReference type="OrthoDB" id="641122at2759"/>
    <dbReference type="PhylomeDB" id="E9FZC9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="SSF46585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REM-1" evidence="6">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="BRO1" evidence="5">
        <location>
            <begin position="91"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="494"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX87285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="585" mass="65247" checksum="FE3956803B1D1A62" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9G043</accession>
    <name>E9G043_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_192459</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PICALM/SNAP91 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX86834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86834"/>
    <dbReference type="EnsemblMetazoa" id="EFX86834">
        <property type="protein sequence ID" value="EFX86834"/>
        <property type="gene ID" value="DAPPUDRAFT_192459"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_192459"/>
    <dbReference type="eggNOG" id="KOG0251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014080_1_1_1"/>
    <dbReference type="InParanoid" id="E9G043"/>
    <dbReference type="OMA" id="HHMLCYG"/>
    <dbReference type="OrthoDB" id="1592722at2759"/>
    <dbReference type="PhylomeDB" id="E9G043"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098894">
        <property type="term" value="C:extrinsic component of presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="PTHR22951"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="SSF48464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="ENTH" evidence="4">
        <location>
            <begin position="14"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX86834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="490" mass="53942" checksum="55FE380093C528DF" modified="2011-04-05" version="1">MSGQTISDRLLAARHSIAGQGLAKAVCKATTEEVIGPKKKHLDYLLHCTNEPNVSIPQLANLLIERSQNSNWVVVFKSLVTTHHLMCYGNERFTQYLASSNCSFQLNNFLDKGNVAGNNIFICLCYDMSPYIRRYAKYLNEKALAYRTVAFDFCKVKRGKEDGTLRTMPADKLLKTLPALQGQIDALLEFDCSANDLTNGVVNTAFLLLFRDLIRLFACYNDGIINLLEKYFEMNKKQCKDALDFYKKFLVRMDRVAEFLKVAENVGIDKGDIPDLTRAPSSLLEALEAHLATLEGKKPTTSSSSNISLAQHNGAMAANAEQIDESLKRQALAEEEAAMNQYKKSTNPFLSSPTSTTAPPPILDLFGSDVDGGSSHTTQSAYDSSHKASDDLLQLAANPFATPTGAAPVIPAMPAQSQAGSWATGPSQNGFGGHFATDNSFVNAFGASANGSTNGECLVFRHFLFVSFFLFMFLFLPSFVCLRFYFQKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E9G149</accession>
    <name>E9G149_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="7">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="7">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_312968</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86606"/>
    <dbReference type="EnsemblMetazoa" id="EFX86606">
        <property type="protein sequence ID" value="EFX86606"/>
        <property type="gene ID" value="DAPPUDRAFT_312968"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312968"/>
    <dbReference type="eggNOG" id="KOG0465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_1"/>
    <dbReference type="InParanoid" id="E9G149"/>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="OrthoDB" id="637899at2759"/>
    <dbReference type="PhylomeDB" id="E9G149"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04097">
        <property type="entry name" value="mtEFG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045044">
        <property type="entry name" value="EFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="PTHR43636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="48"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="124"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="178"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX86606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="753" mass="84489" checksum="16B3448A5D5B75F7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9G2T1</accession>
    <name>E9G2T1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_236661</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX86455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX86455"/>
        <property type="gene ID" value="DAPPUDRAFT_236661"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_236661"/>
    <dbReference type="eggNOG" id="KOG3070">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX86455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="135" mass="15067" checksum="B48A087D44C918CA" modified="2011-04-05" version="1">MSDQEDRPSSGHNASLSSINEGSPSAHLLPNPIITKRTRTQSMLELALDNPVEHVLKIVLFHLFSIDGEYVPRIGDEVSFRKLLVPPKLEKYQAVHVQITNFTPEVHQRWTSALTAEESHEGSRPNSPSSMNVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9G2T8</accession>
    <name>E9G2T8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_230482</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
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        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX86450">
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        <property type="gene ID" value="DAPPUDRAFT_230482"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230482"/>
    <dbReference type="eggNOG" id="KOG3120">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="E9G2T8"/>
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    <dbReference type="OrthoDB" id="1454608at2759"/>
    <dbReference type="PhylomeDB" id="E9G2T8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PTHR20889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
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    <name>E9G729_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84395">
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_960614_0_0_1"/>
    <dbReference type="OrthoDB" id="769798at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX84395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="290" mass="31885" checksum="F11539D13F5013F7" modified="2011-04-05" version="1">MVNGMDDYGGCISGGGYDTGLLASPPYDPTSGVVNIVPASVWAEEIGVYSRGKWSSPSPHLTSMEVPEMWGEVLAEGITELNENNNGLPVRPILLPGLAYTPHHRLLDAIKDHLSVSTVKFKLWKWDCLEYRCPVLPSEAHVTATVYPVADTQGTPVVRPMWYDYYNGGCVHSGKGNSAVVTTRLNHRNMFVVNSSVFLTQQEPGAFAEKTRRNPYTVTTAFPISFTASGWLYVYDGMAADQSAHDLIQFTLTSERRNFNDGAGSFRIPGIGGKFNDCQHPSHIWVGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7V5</accession>
    <name>E9G7V5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ketimine reductase mu-crystallin</fullName>
            <ecNumber evidence="1">1.5.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADP-regulated thyroid-hormone-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_187780</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) = 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58517"/>
            <dbReference type="ChEBI" id="CHEBI:176873"/>
            <dbReference type="EC" id="1.5.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12500"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58517"/>
            <dbReference type="ChEBI" id="CHEBI:176873"/>
            <dbReference type="EC" id="1.5.1.25"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.5.1.25" evidence="1"/>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84593"/>
    <dbReference type="EnsemblMetazoa" id="EFX84593">
        <property type="protein sequence ID" value="EFX84593"/>
        <property type="gene ID" value="DAPPUDRAFT_187780"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_187780"/>
    <dbReference type="eggNOG" id="KOG3007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_1_1_1"/>
    <dbReference type="InParanoid" id="E9G7V5"/>
    <dbReference type="OMA" id="ICIATYS"/>
    <dbReference type="OrthoDB" id="1345495at2759"/>
    <dbReference type="PhylomeDB" id="E9G7V5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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                <person name="Basu M.K."/>
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                <person name="Eads B.D."/>
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    </reference>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <sequence length="263" mass="29176" checksum="30F382EBD5E823D9" modified="2011-04-05" version="1">MEQLVAAKDSRLESLELKVQHQGILEAQMIILETQVNQMKAQAIGVQQQESMLPAKQSRDYSNASSLRQGTTKLPKSCVDLKVMGHTLSGIFLIKGVKTVETVFCDFSLAATNPNFQTWIGFNDIKSSPVSFHAQRENYKVDNAVNSAVNYSLVRLNVGNALNPSTGVFVAPKAGRYYFAFSGLGAFDSVKVQLQMKVGSTDWIKIGEAYGTAWNTMALQSTLQLTKGDQIRLFLLQGTIHDFDNNNFSNFVGYLIEEDVFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEY6</accession>
    <name>E9GEY6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_241731</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732541">
        <property type="protein sequence ID" value="EFX81996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81996"/>
    <dbReference type="EnsemblMetazoa" id="EFX81996">
        <property type="protein sequence ID" value="EFX81996"/>
        <property type="gene ID" value="DAPPUDRAFT_241731"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241731"/>
    <dbReference type="eggNOG" id="KOG3803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_257748_0_0_1"/>
    <dbReference type="InParanoid" id="E9GEY6"/>
    <dbReference type="OMA" id="AMHETIV"/>
    <dbReference type="OrthoDB" id="276220at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="SSF103637"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="346"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="736"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="920"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1042"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1076"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1323"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="557"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="648"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="738"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="920"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1048"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX81996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1350" mass="141714" checksum="ADF8B40589ABB62C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9GFG6</accession>
    <name>E9GFG6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="11">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_211072</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Pritham E.J."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1112" mass="114960" checksum="16EDBE8DDE66A942" modified="2011-04-05" version="1"> </sequence>
</entry>
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    <reference evidence="2 3" key="1">
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX81087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GGV8</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="EFX81290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX81290"/>
        <property type="gene ID" value="DAPPUDRAFT_102613"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9GGV8"/>
    <dbReference type="OrthoDB" id="1767193at2759"/>
    <dbReference type="PhylomeDB" id="E9GGV8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="220" mass="23846" checksum="42C8990964913EAD" modified="2011-04-05" version="1">MNARDRQQALDGGVKKRYDERARPLSPLTIGSHVRIQDPHSSLWDRAGQIVSIGKYRSYRVKFASGSVLWRNRRHLRPLVSDDKDEQQIPGIEGDATTPPADSNVDGLPDTAASQTRPEPVPIPNQPRRSGRIRRPRLMVDVLDWLIRNDDLANAVATPVISSSDSVLVNTCSTFSSSELESAATGDAVKGAGSEKTTFLPDVKPGLGAAVEVVASAPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GH97</accession>
    <name>E9GH97_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_102713</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732544">
        <property type="protein sequence ID" value="EFX81160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX81160">
        <property type="protein sequence ID" value="EFX81160"/>
        <property type="gene ID" value="DAPPUDRAFT_102713"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_102713"/>
    <dbReference type="HOGENOM" id="CLU_1410144_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX81160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="193" mass="20873" checksum="4A2ACDE3B69A0720" modified="2011-04-05" version="1">MCGPVRSLSLMPLGCIGDWIDDVAFEAPRQLIRKALFHTLTNKIYKRELIVLPPTEMQTVCIGSRNPFLLKSGGIAVAFAAVDRPAAGKWPVEWTDPKVRDWPVAGVALLYCDGCCCRFLFNRKCAEDMMSGGKMNSRKLSYLVLTTRPEGDDPLALAPATHTVGTSNQATTMNAALADALMRPNKAAGSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
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    <name>E9GIK2_DAPPU</name>
    <protein>
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            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
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    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_299692</name>
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    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="GL732546">
        <property type="protein sequence ID" value="EFX80675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80675"/>
    <dbReference type="EnsemblMetazoa" id="EFX80675">
        <property type="protein sequence ID" value="EFX80675"/>
        <property type="gene ID" value="DAPPUDRAFT_299692"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG3077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9GIK2"/>
    <dbReference type="OMA" id="HERKCKI"/>
    <dbReference type="OrthoDB" id="1418097at2759"/>
    <dbReference type="PhylomeDB" id="E9GIK2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051443">
        <property type="term" value="P:positive regulation of ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="PTHR12281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="50"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
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        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX80675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="247" mass="28514" checksum="23F991DB55C9390E" modified="2011-04-05" version="1">MPRNSNNSTKRKMDLGEDVSSLFGKRSKTSSNSTVNRSRTKGTEEAPTVFNQKKCNAWFRQYSTPSSPDTIGPEGVEMFCRDLNVEPENIALLVLSWKMGAKQMGYFTLQEWLLGLTDLQCDSLAKLQAKLNYLHSLLLDSSHFKSIYRYAFDFSRDKDQRSLDIETAKAMLGLLLGRQWSLLNSFFQFLDQSRYRVLNKDQWCNVLEFSRAVDVDLKNYDVDGAWPVMLDEFVEWLKVNRGESNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIN5</accession>
    <name>E9GIN5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit O, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Oligomycin sensitivity conferral protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_303877</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX80685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80685"/>
    <dbReference type="EnsemblMetazoa" id="EFX80685">
        <property type="protein sequence ID" value="EFX80685"/>
        <property type="gene ID" value="DAPPUDRAFT_303877"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303877"/>
    <dbReference type="eggNOG" id="KOG1662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085114_0_0_1"/>
    <dbReference type="InParanoid" id="E9GIN5"/>
    <dbReference type="OMA" id="MVDNIQD"/>
    <dbReference type="OrthoDB" id="1178688at2759"/>
    <dbReference type="PhylomeDB" id="E9GIN5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000274">
        <property type="term" value="C:mitochondrial proton-transporting ATP synthase, stator stalk"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX80685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="209" mass="22556" checksum="F296679612D5D92E" modified="2011-04-05" version="1">MAATKFGVLARNFSTSSSSQQLVKAPVQVFGLYGRYASALYSAASKQKSLDKVESELKDFHATIAKDSRLAEFIANPTLKRSLKKDALISVAKKLKMSAVTGNFLELLAENGRLNKLDVVTGHFFTMMAAFRGEVVCEVTSAKALDAATLKEVTAALSGFLQKGQSLKISTKVDPSIVGGLVVVLGDRYIDMSLASKIERYTTLLKQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJX6</accession>
    <name>E9GJX6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_243964</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732548">
        <property type="protein sequence ID" value="EFX80195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80195">
        <property type="protein sequence ID" value="EFX80195"/>
        <property type="gene ID" value="DAPPUDRAFT_243964"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_243964"/>
    <dbReference type="HOGENOM" id="CLU_035079_0_0_1"/>
    <dbReference type="InParanoid" id="E9GJX6"/>
    <dbReference type="OrthoDB" id="222689at2759"/>
    <dbReference type="PhylomeDB" id="E9GJX6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="481" mass="53760" checksum="FEBA9BEB258B410D" modified="2011-04-05" version="1">MAGVNGDNEVPEEETTTPPTQKDLRDATTWKKQRSAVRQQITKTIRYLGNLVNERGSRGSISSMMKHLENLLATAAKIHTNLSTVEDQAENDRQDEFHLKYVELAGDALERGQQYLNSRLGEPPSVIAGKKAPSISPSEQNRQEEERKLAQQRADAAILEADEARRQANEVANRADQARREATAAQQALQALQDLENDDDDTSAVTNGSQHLSQLGQDWRQNQRRLNSSTSPAAPDEWIDRYAAGQLKPNVTASSRSSVKTELEIYSGRSLDWFEWIDLYRALVHDSGKSAGEKLVILKRHLKGDCLDLVQGLGGGESAYIEALVRLKQSCGRRDVMRAATLQAIDKVELKNDPAIFKRFAERIRTHLSDLSRIGESNAPDLIEKISMRHQPPDRLEWNRGRRGGLETRSLNAFDSWLCERAAEYQNAYSIASEQNTSSVLKPPRSHARSHPASSAKAPDNHSAPKVTFRPLCFKCEGDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GP30</accession>
    <name>E9GP30_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_245794</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732556">
        <property type="protein sequence ID" value="EFX78571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78571">
        <property type="protein sequence ID" value="EFX78571"/>
        <property type="gene ID" value="DAPPUDRAFT_245794"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_245794"/>
    <dbReference type="HOGENOM" id="CLU_149565_0_0_1"/>
    <dbReference type="InParanoid" id="E9GP30"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="PhylomeDB" id="E9GP30"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX78571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="120" mass="12970" checksum="C75503E2649E7BC6" modified="2011-04-05" version="1">MQFLPDEDFVHLVHCSALIAAVSMTTVSAQWNKGDGGVIWQMNCRYVGDYIALKSSSSEQCGGVCIAQSGCTHFTHGPSPQGDGHCYMYSTTHPTEKQTILGQTDGFVVSFPVVLLVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPW4</accession>
    <name>E9GPW4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_128674</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Casola C."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX77855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77855"/>
    <dbReference type="EnsemblMetazoa" id="EFX77855">
        <property type="protein sequence ID" value="EFX77855"/>
        <property type="gene ID" value="DAPPUDRAFT_321073"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_321073"/>
    <dbReference type="eggNOG" id="KOG1943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166525_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GRU3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0034333">
        <property type="term" value="P:adherens junction assembly"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="PTHR12658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX77855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="85" mass="9766" checksum="F19370EB07E70742" modified="2011-04-05" version="1">MERILNVCKKYLAGTTKAQDIAFYVSEIYLTRPDVKDSYLPGFINWAHEVLTKDSAQFKKGVLSTLAGVFKHGQREQMMWRLAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9GS47</accession>
    <name>E9GS47_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_25570</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732561">
        <property type="protein sequence ID" value="EFX77646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77646"/>
    <dbReference type="EnsemblMetazoa" id="EFX77646">
        <property type="protein sequence ID" value="EFX77646"/>
        <property type="gene ID" value="DAPPUDRAFT_25570"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_25570"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_7_1"/>
    <dbReference type="InParanoid" id="E9GS47"/>
    <dbReference type="OMA" id="NIRHLKC"/>
    <dbReference type="OrthoDB" id="1091615at2759"/>
    <dbReference type="PhylomeDB" id="E9GS47"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032488">
        <property type="term" value="P:Cdc42 protein signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030707">
        <property type="term" value="P:ovarian follicle cell development"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
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        <property type="entry name" value="PTHR24072"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX77646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="175" mass="19245" checksum="82447D5370DD2D12" modified="2011-04-05" version="1" fragment="single">RIKCVLVGDGAVGKTSLIVSYTTNGYPTEYIPTAFDNYNVVVNVDNQPILLQLCDTAGQDDFDNLRTLCYDSTDVYVVCFSVVSPASFANVASRWLPEIRRHSPDTPVILVGTQADLRSDVKVLIELARYGEKPVGELEAIRLADRLGARTYVESSALTQRNLKEVFDEAIVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GSX3</accession>
    <name>E9GSX3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_247680</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732562">
        <property type="protein sequence ID" value="EFX77509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77509">
        <property type="protein sequence ID" value="EFX77509"/>
        <property type="gene ID" value="DAPPUDRAFT_247680"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_247680"/>
    <dbReference type="HOGENOM" id="CLU_2457060_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003237414" evidence="2">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX77509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="89" mass="9185" checksum="8C0EF240CC045A58" modified="2011-04-05" version="1">MAKVYMNTLKCFLLFGLVLVHGPDATKGKGRGGGGYGMSYGGGGGYGGGGPKISNGGPPNLPVTQMQMQRRQGAPTHLVHRPCVSNPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9GSZ8</accession>
    <name>E9GSZ8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KH_dom_type_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_106232</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732563">
        <property type="protein sequence ID" value="EFX77358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77358">
        <property type="protein sequence ID" value="EFX77358"/>
        <property type="gene ID" value="DAPPUDRAFT_106232"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_106232"/>
    <dbReference type="HOGENOM" id="CLU_1397655_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GSZ8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH_dom_type_1" evidence="1">
        <location>
            <begin position="77"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="195" mass="22267" checksum="BBD201C9A5F25827" modified="2011-04-05" version="1">MSFVESIKPRLFSPWNHESFHKQTIQPNLNSILKMPKAQQVHFPIGDVRYKNKPMSGYVVNPDGTQVNVEEHSGWRLRRIIGGGGSNIRRIETQYQIVARLTTSPDGNFSFLITGYTEEVRQATTDDIVRGLTVTAEFPNSKLPKRIKNIRLDEIGRKYFVRINRPSDNNGNITLTGRLSRSQSAYAEIMGKEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTX1</accession>
    <name>E9GTX1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_54762</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="GL732565">
        <property type="protein sequence ID" value="EFX76932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76932"/>
    <dbReference type="EnsemblMetazoa" id="EFX76932">
        <property type="protein sequence ID" value="EFX76932"/>
        <property type="gene ID" value="DAPPUDRAFT_54762"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_54762"/>
    <dbReference type="eggNOG" id="KOG1253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010862_4_1_1"/>
    <dbReference type="InParanoid" id="E9GTX1"/>
    <dbReference type="OMA" id="YRVSYSH"/>
    <dbReference type="OrthoDB" id="1414511at2759"/>
    <dbReference type="PhylomeDB" id="E9GTX1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004809">
        <property type="term" value="F:tRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="PTHR10631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 7" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX76932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="512" mass="56530" checksum="B74C201C5F1D6867" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9GV27</accession>
    <name>E9GV27_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_106826</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732567">
        <property type="protein sequence ID" value="EFX76593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76593">
        <property type="protein sequence ID" value="EFX76593"/>
        <property type="gene ID" value="DAPPUDRAFT_106826"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_106826"/>
    <dbReference type="HOGENOM" id="CLU_1760639_0_0_1"/>
    <dbReference type="OrthoDB" id="894470at2759"/>
    <dbReference type="PhylomeDB" id="E9GV27"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="148" mass="16130" checksum="463B3EDA53F803AE" modified="2011-04-05" version="1">MIIDVHQTTRKTTTTITDRSGNVADLGRIRAGCVDVEVPGGGSRINGGRGRGKSNSPTTTLPSNNQDEVEETDWLAWPGEDPAQYANNEENAETSEGDEDGKGLYWFTDARTNLLLATYKPLEKKFAGHRQPIQLWGKIAGTLQEKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9GV31</accession>
    <name>E9GV31_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_248722</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732567">
        <property type="protein sequence ID" value="EFX76595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76595">
        <property type="protein sequence ID" value="EFX76595"/>
        <property type="gene ID" value="DAPPUDRAFT_248722"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_248722"/>
    <dbReference type="HOGENOM" id="CLU_038513_0_0_1"/>
    <dbReference type="InParanoid" id="E9GV31"/>
    <dbReference type="OrthoDB" id="222689at2759"/>
    <dbReference type="PhylomeDB" id="E9GV31"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="532" mass="61305" checksum="90B16DF7EBE76C44" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9GVA5</accession>
    <name>E9GVA5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DAPPUDRAFT_54951</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TMTC family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="8"/>
    <dbReference type="EMBL" id="GL732567">
        <property type="protein sequence ID" value="EFX76641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76641"/>
    <dbReference type="EnsemblMetazoa" id="EFX76641">
        <property type="protein sequence ID" value="EFX76641"/>
        <property type="gene ID" value="DAPPUDRAFT_54951"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_54951"/>
    <dbReference type="eggNOG" id="KOG1124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011615_4_0_1"/>
    <dbReference type="InParanoid" id="E9GVA5"/>
    <dbReference type="OMA" id="DYTCLFC"/>
    <dbReference type="OrthoDB" id="1320023at2759"/>
    <dbReference type="PhylomeDB" id="E9GVA5"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked mannosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="10 12" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240619" description="Dolichyl-phosphate-mannose--protein mannosyltransferase" evidence="14">
        <location>
            <begin position="23"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="15">
        <location>
            <begin position="243"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="477"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="590"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="627"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="661"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="695"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="763"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFX76641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="825" mass="92981" checksum="955D5E77C11AB4F2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9GVI3</accession>
    <name>E9GVI3_DAPPU</name>
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        <recommendedName>
            <fullName evidence="9">Not3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_198891</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732568">
        <property type="protein sequence ID" value="EFX76526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76526"/>
    <dbReference type="EnsemblMetazoa" id="EFX76526">
        <property type="protein sequence ID" value="EFX76526"/>
        <property type="gene ID" value="DAPPUDRAFT_198891"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_198891"/>
    <dbReference type="eggNOG" id="KOG2150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073755_0_0_1"/>
    <dbReference type="InParanoid" id="E9GVI3"/>
    <dbReference type="OMA" id="CECKIES"/>
    <dbReference type="OrthoDB" id="1109812at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="PTHR23326"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Not3" evidence="9">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX76526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="274" mass="32418" checksum="E6357A6703DC6EAB" modified="2011-04-05" version="1">MAATRKLQGEIDRCLKKVTEGVELFEDIWQKVHNAANSNQKEKYETDLKKEIKKLQRLRDQIKSWIQSAEIKDKSQLVENRKLIETQMERFKIVERETKTKAYSKEGLGAAQKLDPAQKEREDISQWLNTSIENLNIQIDQFECEIESLLAAKKKKLDKDKQERLDKLKEFLERHRFHIRKLETLLRMLDNLTVEVTQIKKIKDDIEYYIEAASTDPDFEENTYLYDDINFLDEFADVVGTVGGNFWSCFVLFSFLSSLLGFNWNSNWIMFEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GVX6</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2">
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_322426"/>
    <dbReference type="HOGENOM" id="CLU_1867135_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GVX6"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="150" mass="17818" checksum="2398F538460FF870" modified="2011-04-05" version="1">MAKSLEERWMKLSEGEKEPYRRLMEKRNNVIEEEIKILDNIIIAKRPGRRSYSGEKLTVRIPEKEKPMEDKMGLNPIFWFFCDDFRKSISDNPNWCNNIMEMQTRTVKKWSTLSKEIQGDCIHRAKNQFEFYTGSTDGNEVVDHNLLITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GXF3</accession>
    <name>E9GXF3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
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            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1143555_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GXF3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="224" mass="24584" checksum="557B82A142096301" modified="2011-04-05" version="1">MEKRVIKQLAINNLAVAAYFSTSLAISLGPDTEFSDPVTGRVFRILGETRSFINFGNTPTTAILYVVADHEIGFPVILGMDTLLALGVEIIMNKTSQMNPLYPIPGENPPILSTGLTTSMASEEWFHDKTDAVAINYNGPPTIHDPVTKTTINIIGKARYPLPRKSTFCILIAEIPAWLVYGLDALVLGNLKLKFPGASISWPQPAVMRWDRPIPHRRGPTCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYC5</accession>
    <name>E9GYC5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_250334</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732574">
        <property type="protein sequence ID" value="EFX75576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75576"/>
    <dbReference type="EnsemblMetazoa" id="EFX75576">
        <property type="protein sequence ID" value="EFX75576"/>
        <property type="gene ID" value="DAPPUDRAFT_250334"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_250334"/>
    <dbReference type="eggNOG" id="KOG3575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2212570_0_0_1"/>
    <dbReference type="InParanoid" id="E9GYC5"/>
    <dbReference type="PhylomeDB" id="E9GYC5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="29"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX75576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="107" mass="12502" checksum="13B46DE1FF3FCCD6" modified="2011-04-05" version="1">MEISQQKLGSEHFEKEKDETEEGKETQQQERCLVCFDIALNYVTYGARTCGNCAAFFKTTIDESRNFVCFYSNNCNSSHEYRCEFPNTSCKSCRFQQYLKIGMKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZ78</accession>
    <name>E9GZ78_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_306867</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732577">
        <property type="protein sequence ID" value="EFX75100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75100"/>
    <dbReference type="MEROPS" id="T01.020"/>
    <dbReference type="EnsemblMetazoa" id="EFX75100">
        <property type="protein sequence ID" value="EFX75100"/>
        <property type="gene ID" value="DAPPUDRAFT_306867"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306867"/>
    <dbReference type="eggNOG" id="KOG0174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_5_2_1"/>
    <dbReference type="InParanoid" id="E9GZ78"/>
    <dbReference type="OMA" id="HKQAYAI"/>
    <dbReference type="OrthoDB" id="1172133at2759"/>
    <dbReference type="PhylomeDB" id="E9GZ78"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035140">
        <property type="entry name" value="Proteasome_beta6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF46">
        <property type="entry name" value="PTHR11599:SF46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX75100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="225" mass="24369" checksum="CA4CB4533585CEDF" modified="2011-04-05" version="1">MACTMNNSISDLLSPDWLTSEHSTGTSIMAVEFNGGVVIGADSRTSTGAYVANRVTDKLTKITNHIYCCRSGSAADTQAIADIVNYHLEFHEVQLGEAPLVKTAASVFQELCYNYRDQLTAGIICAGWDRRHGGQVFNIPLGGMCVRQSFAIGGSGSTYVFGFVDSNFKKGMIKDECVQFVLKTLALAMSRDGSSGGVVRLGIITEDGIERRTVLGNELPRFYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZB3</accession>
    <name>E9GZB3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_8854</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732577">
        <property type="protein sequence ID" value="EFX75119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75119">
        <property type="protein sequence ID" value="EFX75119"/>
        <property type="gene ID" value="DAPPUDRAFT_8854"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_8854"/>
    <dbReference type="HOGENOM" id="CLU_3074644_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="53" mass="5111" checksum="EB7553C333F26E02" modified="2011-04-05" version="1" fragment="single">PGFDGAHGSDEKDGFPGEKGENGCNGSPGLTGYNGSTGKDGLPGAPGYPSKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZC8</accession>
    <name>E9GZC8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prostaglandin E synthase 2</fullName>
            <ecNumber evidence="4">5.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Microsomal prostaglandin E synthase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PGE2</name>
        <name evidence="18" type="ORF">DAPPUDRAFT_56335</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde</text>
            <dbReference type="Rhea" id="RHEA:48644"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:90694"/>
            <dbReference type="ChEBI" id="CHEBI:566274"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:48645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>prostaglandin H2 = prostaglandin E2</text>
            <dbReference type="Rhea" id="RHEA:12893"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="5.3.99.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:12894"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; prostaglandin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.99.3" evidence="4"/>
    <dbReference type="EMBL" id="GL732577">
        <property type="protein sequence ID" value="EFX75129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75129"/>
    <dbReference type="EnsemblMetazoa" id="EFX75129">
        <property type="protein sequence ID" value="EFX75129"/>
        <property type="gene ID" value="DAPPUDRAFT_56335"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_56335"/>
    <dbReference type="eggNOG" id="KOG3029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_0_0_1"/>
    <dbReference type="InParanoid" id="E9GZC8"/>
    <dbReference type="OMA" id="AYLDYMG"/>
    <dbReference type="OrthoDB" id="1042777at2759"/>
    <dbReference type="PhylomeDB" id="E9GZC8"/>
    <dbReference type="UniPathway" id="UPA00662"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036134">
        <property type="term" value="F:12-hydroxyheptadecatrienoic acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050220">
        <property type="term" value="F:prostaglandin-E synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03197">
        <property type="entry name" value="GST_C_mPGES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034334">
        <property type="entry name" value="PGES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034335">
        <property type="entry name" value="PGES2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01203">
        <property type="entry name" value="Prostaglandin_E_synthase_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GST N-terminal" evidence="17">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFX75129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="282" mass="32696" checksum="2903927A628205EF" modified="2011-04-05" version="1" fragment="single">LNIFLQVEGNKDTSNLQLTLFQYEPCPFCKKVRAYLDFAGLSYDVVEVNPVTKKQLNWSAYKKVPIVVVKVEEGYQQLNDSSMIISSLASHLVDPDQDLTTVVKYYPQVDFQDTNGKKGSEIMNRYFLMFGDNESTGRSKESIMEERKWRKWSDDVLMHTISPNIYRTWEESLEAFNMFSKNGDWERIFSSWERQMVIYVGAAVMYLIGKRLKKRHNILDDARQSLYNEVNYFLKTVDEKGTPFLGGDVPNLADLAVYGCFSSIDGTRTFDELMDHTKLSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9H031</accession>
    <name>E9H031_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_251269</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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    <sequence length="82" mass="8471" checksum="F2BD0A4EA187F463" modified="2011-04-05" version="1">MGYTVLTSSDMSLTPSPSNTVALRVHPITGAQSMIQTVAAPIALLVTNPVAPPIELTQPILTSAVTLSLPTANQECQEPGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9H3C2</accession>
    <name>E9H3C2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_109514</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732588">
        <property type="protein sequence ID" value="EFX73737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73737">
        <property type="protein sequence ID" value="EFX73737"/>
        <property type="gene ID" value="DAPPUDRAFT_109514"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_109514"/>
    <dbReference type="HOGENOM" id="CLU_1512150_0_0_1"/>
    <dbReference type="OrthoDB" id="1587309at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX73737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="178" mass="19609" checksum="5A899E4829DB90A1" modified="2011-04-05" version="1">MAITAREAFSKAIVASHGEPRDSLVLKGGNIKITPISKAQQFSLLNISEIAGRKIKTSLPDSPAAIRNGIIFGVPSSDNEDELLVALADQNVTHVKRLPVGTVCVVAVHAMHVDSPLGYPSWSGIRFASSTITGMDPLEEFRWVTSIAVTDYRYQSVTDYRPHHLEVRIIIRELKNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9H4W3</accession>
    <name>E9H4W3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_110001</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732592">
        <property type="protein sequence ID" value="EFX73280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73280">
        <property type="protein sequence ID" value="EFX73280"/>
        <property type="gene ID" value="DAPPUDRAFT_110001"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_110001"/>
    <dbReference type="HOGENOM" id="CLU_055342_1_0_1"/>
    <dbReference type="InParanoid" id="E9H4W3"/>
    <dbReference type="OrthoDB" id="940319at2759"/>
    <dbReference type="PhylomeDB" id="E9H4W3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001973">
        <property type="term" value="P:G protein-coupled adenosine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F1_2" evidence="6">
        <location>
            <begin position="37"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX73280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="351" mass="38845" checksum="203B8BA0B1F0F3F8" modified="2011-04-05" version="1">MSNSSNISSTTDGHLQDDLDTFLIVSKFISCSVGIPLNLSVVVAITRNRQLRNQPRNIFLLGIIFSYLVFFVPAIIELIDWKLSSMLESVCQANVAVIGPPHALLLLNMSLALIDRYVAINHPVWYRQKMTVSLASALVILSSAFIVLIVKFLYILGLGADAKNSCQMWNVHTRTLAVVLVILFSICTALNLIVYRQTPNSDDSTHRMEPMTAEGEGVEWVEFDDFGNESRINQTTSAIGSLVDDLSASIRSMPVIIHLDDVMSATEIKATRTLIVGVTSFVATAYVSVVFVSSFFACRMILGELQCGNLTWMGRYLGELSLIPAFYGSLIFLMGNQELRKTWACKNELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E9H559</accession>
    <name>E9H559_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative diuretic hormone 44 receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_290680</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732593">
        <property type="protein sequence ID" value="EFX73074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX73074"/>
    <dbReference type="EnsemblMetazoa" id="EFX73074">
        <property type="protein sequence ID" value="EFX73074"/>
        <property type="gene ID" value="DAPPUDRAFT_290680"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_290680"/>
    <dbReference type="eggNOG" id="KOG4564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002753_4_1_1"/>
    <dbReference type="InParanoid" id="E9H559"/>
    <dbReference type="OMA" id="RINYSHC"/>
    <dbReference type="OrthoDB" id="1163977at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008036">
        <property type="term" value="F:diuretic hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="GPCR_2-like"/>
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        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
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        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
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        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
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        <property type="entry name" value="7tm_2"/>
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    </dbReference>
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        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01127">
        <property type="entry name" value="DIUHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF111418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
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    </dbReference>
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            <begin position="116"/>
            <end position="136"/>
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        </source>
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        </source>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX73074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="427" mass="48634" checksum="BBC4F49B9A31D846" modified="2011-04-05" version="1">MALNITNENELDCLFNFLRESYPPAGFEAITSFCNSTWDGVSCWPTTLGGSTSVLPCVDELNGIKYDTTHNATRVCQPNGTWTNYSNYRSCVPLSSDFGGATPEYGVGISEDTTTIYFTGYTVSIVALTLAIWIFIHFKDLRCLRNTIHTHLLITYIMADLLWIVTATLQLYRGETNKGSCIIVIFLHYFHLTNFFWMFVEGFYLYMLVVETFSADKIRLRIYAFIGWGIPLPVVIVWAVVKANWFTYTSTEGQHLDLESFLASCPWMAANSYDWIYMTPAIVVLFVNILFLVKIMWVLITKLRSANSVETQQYRKGSKALLVLIPLLGLTYVLVIAGPTEGLIAIYFSHIRAVLLSTQGFLVTLFFCFLNTEVRNTLRHHWTRWKTTSRWLEHSQNHSSRSNRCGTAINSKRNSKDGSRAPCESTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9H756</accession>
    <name>E9H756_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GABP-alpha domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_326201</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX72505.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="GABP_asu_N"/>
    </dbReference>
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        <property type="entry name" value="GABP-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GABP-alpha" evidence="1">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX72505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="110" mass="12540" checksum="1122254AE21264C3" modified="2011-04-05" version="1">MDDVFLSEVDLDGHEEWDTLTDETTLSEQCIQGEKLVQVNLELKSVQNIDRINIIDVLKPQQDKDINLNEEEIMEGIKDPEEIKVPVPDPVLEEVSNVALQGVTYQADEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9H775</accession>
    <name>E9H775_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOPB13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOPB13</name>
        <name evidence="12" type="ORF">DAPPUDRAFT_346979</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732600">
        <property type="protein sequence ID" value="EFX72330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72330"/>
    <dbReference type="EnsemblMetazoa" id="EFX72330">
        <property type="protein sequence ID" value="EFX72330"/>
        <property type="gene ID" value="DAPPUDRAFT_346979"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_346979"/>
    <dbReference type="HOGENOM" id="CLU_009579_3_0_1"/>
    <dbReference type="InParanoid" id="E9H775"/>
    <dbReference type="OrthoDB" id="911005at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008020">
        <property type="term" value="F:G protein-coupled photoreceptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071482">
        <property type="term" value="P:cellular response to light stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0157">Chromophore</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F1_2" evidence="11">
        <location>
            <begin position="73"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX72330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="346" mass="38679" checksum="8F4DDF52AC14F051" modified="2011-04-05" version="1" fragment="single">MANLTGDAVVAMAQKQAFDPWALPDTFTLYAYAPEDIRSFLHPHWHSYKAVHPAWYYFLGLMYLVIGTCAVAGNAVVLKIFSRFPALRTPANLLVMNLAVSDFLLMLALFPECVYNFFLGGPWRFGEMGCQIHAFLGACFGYNQIFTLTMISYDRYNVIVKGFSGTPLTFNRAVSIITVSWIWALGWSICPLVGWGAYAMDGIMGTCSYDYVSQNMNNKSHILAATFANFILPIIVIAGCYYFIVHAVFKHEEELRAQAKKMNVASLRSNTDQQQVSAEIRIAKVSIMNVSMWLTAWTPFAVICIMGTWGDVSKITPLVSAIPVILAKTSCAYNPLIYAISHPKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9H7Z8</accession>
    <name>E9H7Z8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Focal_AT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_326512</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732602">
        <property type="protein sequence ID" value="EFX72118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72118"/>
    <dbReference type="EnsemblMetazoa" id="EFX72118">
        <property type="protein sequence ID" value="EFX72118"/>
        <property type="gene ID" value="DAPPUDRAFT_326512"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326512"/>
    <dbReference type="eggNOG" id="KOG4257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055889_0_0_1"/>
    <dbReference type="InParanoid" id="E9H7Z8"/>
    <dbReference type="OrthoDB" id="43729at2759"/>
    <dbReference type="PhylomeDB" id="E9H7Z8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007172">
        <property type="term" value="P:signal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036137">
        <property type="entry name" value="Focal_adhe_kin_target_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005189">
        <property type="entry name" value="Focal_adhesion_kin_target_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03623">
        <property type="entry name" value="Focal_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68993">
        <property type="entry name" value="SSF68993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Focal_AT" evidence="2">
        <location>
            <begin position="255"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX72118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="326" mass="36294" checksum="27EBB37021EBA601" modified="2011-04-05" version="1">MAGEILMEERRERNGTMSRENRRVAAISWSSTGSAGNGEDLPPPKPSRVQATYVGVGGSAGSEVLAQLMRDNETRAAAGHYTAPASAFNTFTVEFSHTSLSNSNPASPQHKSKTKGRKNQPLYANIMMADATPASIASAAVATNPAPYKDEPNEPSREHMEQERRMLEWKLRQQQRQSEDDSRWLAEEERHMRKRLSVAASSSDRYDTDSMDGANAYQKDRSTPLQGNQLDDRSVVVKKLEPTPTARLDQTHEKVYDATSVVRAVGLELRTILTSVDQLVPHFPPSTHREVEMAHKVLSKDMAELVSALKLDERCSNTTLDNEYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9L8</accession>
    <name>E9H9L8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ammonium_transp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_327164</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732609">
        <property type="protein sequence ID" value="EFX71522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71522"/>
    <dbReference type="EnsemblMetazoa" id="EFX71522">
        <property type="protein sequence ID" value="EFX71522"/>
        <property type="gene ID" value="DAPPUDRAFT_327164"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_327164"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_1_1"/>
    <dbReference type="InParanoid" id="E9H9L8"/>
    <dbReference type="OMA" id="WFLYNAM"/>
    <dbReference type="OrthoDB" id="910733at2759"/>
    <dbReference type="PhylomeDB" id="E9H9L8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072488">
        <property type="term" value="P:ammonium transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="6">
        <location>
            <begin position="34"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX71522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="435" mass="47566" checksum="F9DCFD286312216F" modified="2011-04-05" version="1">MGSSWKMMVNETYSLLLVEQQELESFKKNMDDLFLIIMGNFVFFLQPGFFLYESGTVRQKNVVSVAFRKFINTTISSLTYFLTGFALSFGDGNGFCGFQYFALVNLPDEMMAECFFQYTFAAVASSVPSGVVHERSSTVAFVSYTALTSGFIYPIAAHWVATKNGWLSRLGFDDFAFSGVVHAMSGATCLAAAWMTGPRLDRYQSGGQRRVVISPHSVPQMILGAFVFLFGMIAFNAGSQGSISQSGDGSIIAQVTINTLICAMTSAVTGLIYHRFIVDRSKKNWNYSSCVNGSFVGMVAICAGCNQFQCGGAFALGILSYLLYLAIQAIVEKLKVDDVVDGIAIQLGGGYAGLLSVPLFKDDGLLTNPSKSSPWGLLINAGGGIVIMLWSFSITILLYIVLRYFDLHRVSPSDEKLGLDMVIHKEKAYDHTTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9M2</accession>
    <name>E9H9M2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_327169</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kultz D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="422" mass="46194" checksum="2A906DA5D0E5367C" modified="2011-04-05" version="1">MFKVSRCLPLVQLTSKLSKNAQGLLPTSQLASRQIATKVQPLTQLNEDELMMKESVAKLASQIIAPFVKKMDIQQSFEPDVVNALFANGLMGLEIDAEYGGAGASFMSAIVTIEELAKIDPAVSVFCDIQNTLINTLFRKLGTQEQKDKYLPKLAQDTVGSFCLSEAESGSDAFSLKTRAIKSDDHYIINGSKMWISSSEIAGVYLVMANANPKDGYKGITCFIVDQITPGVSIGKKEDKLGIRASSTCAVHFDNVQVPASNILGELGQGYKYAIGMLNEGRIGIGAQMVGLAQGCFDATVPYTLQRTQFGKRIFDFQAMQHQIAQVATQIESARLLVYNAARLKEAGLPFVKEAAMAKYYAAEVATLTTSKCIEWMGGVGFTKDYPVEKFYRDCKIGTIYEGTSNIQLNTIAKYIEQEYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="EnsemblMetazoa" id="EFX70811">
        <property type="protein sequence ID" value="EFX70811"/>
        <property type="gene ID" value="DAPPUDRAFT_327799"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_327799"/>
    <dbReference type="eggNOG" id="KOG0200">
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <begin position="1"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
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    <organism evidence="3">
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX69763.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="179" mass="20145" checksum="3BAC830F91D1EBFB" modified="2011-04-05" version="1">MYFTEFKNCIRNSGESIRDYACRLQKLYSFAYPTEVGKPVDQAVLRLRETMLMDGFLGGLKPNLRERMGFKDYKNLNDLIKATEKCAAVLSEAKLEKQSVEFVNAISANANTREIRETKNGIELKSVIEQLTQQLSTTMIADQGHEAVNAVATTQTAQLSESKKEIEELKNLLKASNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGH6</accession>
    <name>E9HGH6_DAPPU</name>
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        <recommendedName>
            <fullName evidence="5">Procollagen-proline 4-dioxygenase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DAPPUDRAFT_228756</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69155"/>
    <dbReference type="EnsemblMetazoa" id="EFX69155">
        <property type="protein sequence ID" value="EFX69155"/>
        <property type="gene ID" value="DAPPUDRAFT_228756"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_228756"/>
    <dbReference type="eggNOG" id="KOG1591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024155_1_1_1"/>
    <dbReference type="InParanoid" id="E9HGH6"/>
    <dbReference type="OMA" id="ITNKWIR"/>
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    <dbReference type="PhylomeDB" id="E9HGH6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0005788">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018401">
        <property type="term" value="P:peptidyl-proline hydroxylation to 4-hydroxy-L-proline"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="Pro_4_hyd_alph_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PTHR10869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241779" description="Procollagen-proline 4-dioxygenase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="429"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="375"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX69155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="570" mass="63973" checksum="2C3B8BD6B02C10C6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGS9</accession>
    <name>E9HGS9_DAPPU</name>
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        <recommendedName>
            <fullName evidence="2">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_301176</name>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732643">
        <property type="protein sequence ID" value="EFX69013.1"/>
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        <property type="protein sequence ID" value="EFX69013"/>
        <property type="gene ID" value="DAPPUDRAFT_301176"/>
    </dbReference>
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        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DBH-like"/>
    </dbReference>
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        <property type="entry name" value="DOH_DOMON"/>
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        <property type="entry name" value="DOMON_domain"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241950" description="DOMON domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="2">
        <location>
            <begin position="32"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX69013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="175" mass="19001" checksum="919049C536F653A0" modified="2011-04-05" version="1">MMKLFVALAGLLALCGAQTTNYPFSAYLDTDGYFLMKWDIRATQGDIEMQFVVNTTGWLSLLIASEDGSYADVIFGGFNEATTYGYYTDMHCDLLAGPSHTAPENDASNDLIYQSATYTAPYTTLTVKRSIYTGDKDDVAIRPGPLLLGWSFSDKDTSTAVHTNAGFATLAIIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGT9</accession>
    <name>E9HGT9_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_329514</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX69018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX69018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="97" mass="11160" checksum="DA532B3BA89FED78" modified="2011-04-05" version="1">MASHHDGGASKIAKAAVLSFFATCLIIIIAFSTNSWLETDGTLENPKFIQLGLWNFCLKEFKDVKHLYDRVFNGCRHVLDEEYHIIDWLLRPHSIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DAPPUDRAFT_330043"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_111284_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HIE2"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX68485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="122" mass="14461" checksum="C05D7C02ED6A4445" modified="2011-04-05" version="1">MNCSEIDQAAEADKMMAEYCEELDYLETLIEEVVATLKVDNDFWKIRAMLSELRKAFDSIQKPNSECLEEQLHFEKKLIYYLREETTESTTIDAVCTWIDVSENALQVYFLLNLFYQIFNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
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    <name>E9HML9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732688">
        <property type="protein sequence ID" value="EFX67018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67018">
        <property type="protein sequence ID" value="EFX67018"/>
        <property type="gene ID" value="DAPPUDRAFT_262233"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_262233"/>
    <dbReference type="HOGENOM" id="CLU_1604374_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="178" mass="20333" checksum="56FFA20CBC8B19E5" modified="2011-04-05" version="1">MHQLEALQKSLMPVQDGIIALIKLTAKLTKDTEKAEATAVLEELRKADASMRDRLFVLQVWRKYDQETADKFARRKAGEFLDPDLAKVLEDQEKRADRIKREPKDKQMFRSQPKRFRGSYYEGHGSNSPDFSSQQHFGRGGYGSRGRGGGTRGRKQPGPDNKCHKCGSTEHFFKNCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HMM7</accession>
    <name>E9HMM7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_262244</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the histone H3 family.</text>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Histone_H3/CENP-A"/>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX66448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Pritham E.J."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="92" mass="10388" checksum="D91484417A419D10" modified="2011-04-05" version="1">MFIALQCCRPEALNPSIFYFFDECGTDVNSPANDLSRPLHLASREGHTNAVQHLLERGAGDSLKDSHGRTGSVLFRDLFLFTALRQWFNKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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    <organism evidence="2">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Rechtsteiner A."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="108" mass="13028" checksum="BCEC30DE31D91816" modified="2011-04-05" version="1">MALNYANYEEFAGEEPYYQYQDGLQLFQFIGSISRLNMFFSHPNFHLRGTFPQDWSDMSLSRRRFSTIKFIEYLITDFVTENFVTNEEAKRQEKNELEKITREELESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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                <person name="Andrews J."/>
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                <person name="Tang H."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732756">
        <property type="protein sequence ID" value="EFX65209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1442456_0_0_1"/>
    <dbReference type="InParanoid" id="E9HSR6"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="174"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX65209.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="188" mass="21301" checksum="EF2B14FBC9A42FFF" modified="2011-04-05" version="1">MAPTAKNTRSGVKGHVTRIINFIRAYQSTPMSERASSELTEQEKRLREKFESFKTLTLQVQEDMVTEEATDQELQAEIDYVAATEEEVSDAKVIMDYKQKEWREEKERIRKEEKEQKKEEGGGGKGAETPQHSPTTTTAECSRSSVTTTTTCSFYAAIDRRHSSSQSSTRSAKRSSNNSHHEITTKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="EnsemblMetazoa" id="EFX65159">
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        <property type="gene ID" value="DAPPUDRAFT_347700"/>
    </dbReference>
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    <dbReference type="PhylomeDB" id="E9HSV9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="886" mass="103752" checksum="128147BA44E9213B" modified="2011-04-05" version="1"> </sequence>
</entry>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="112" mass="12247" checksum="AAF5C85B13656F69" modified="2011-04-05" version="1">MGENSVTESRSPSPNKRGSDNDVASLRRDIERQQILQRLIASQVPNNTSDAGGMDANVAAQFQLQLDLKAEKKVGITFARMMEMVKADITSSETETSAGEEQSKCIELVDTE</sequence>
</entry>
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    <reference evidence="2 3" key="1">
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                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
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                <person name="Manak J.R."/>
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                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="74"/>
            <end position="330"/>
        </location>
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        <location>
            <begin position="762"/>
            <end position="825"/>
        </location>
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        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="701"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="853"/>
            <end position="876"/>
        </location>
    </feature>
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        <location>
            <begin position="787"/>
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        </location>
    </feature>
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        <location>
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            <end position="685"/>
        </location>
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            <begin position="701"/>
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        </location>
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        <location>
            <begin position="745"/>
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        </location>
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        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX64522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="922" mass="103168" checksum="6ECADC0DF2C114CA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="2">Complex I-49kD</fullName>
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        <alternativeName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase 49 kDa subunit</fullName>
        </alternativeName>
    </protein>
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        <name evidence="5" type="ORF">DAPPUDRAFT_66167</name>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 49 kDa subunit family.</text>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="100" mass="11034" checksum="66855AF78658489F" modified="2011-04-05" version="1">MRTKRSEMKTSMEALIHHLKLFTQGYNVPPGATYTAVDNPKGEFGVYLVSDGTSRPYRCKIKAPGFAHLAALEKVGRNHMLADIVAIIGTLDVVFGEIDR</sequence>
</entry>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX64502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_266283"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3034491_0_0_1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX64502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="55" mass="6389" checksum="BF92CAC04588EDAE" modified="2011-04-05" version="1">MFKIPPPAEENPMLACTKPFHLEIMIEFDNWRIPKQTWIALIALVAILPLMLADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HXU7</accession>
    <name>E9HXU7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_119216</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX63432.1"/>
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        <property type="gene ID" value="DAPPUDRAFT_119216"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1671119_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="158" mass="16657" checksum="3A187707E5443619" modified="2011-04-05" version="1">MGHKSLNYLNEDPLAGGNGTPTHPPQEPPAKRAKREELGPTGPRWRKQLLDGATWPWERSGALSVLATIKAHRDLALILGDTGPATMEQRPAMGAEETLIAPKARKEATTARKEATTARKVATPASTTIGSVTSKAGVRETPASIPTTVATSVFAISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HYY7</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DAPPUDRAFT_269180</name>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733246">
        <property type="protein sequence ID" value="EFX63043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX63043"/>
        <property type="gene ID" value="DAPPUDRAFT_269180"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_269180"/>
    <dbReference type="HOGENOM" id="CLU_1350129_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HYY7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX63043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="203" mass="22879" checksum="F25CC3D58A73F75D" modified="2011-04-05" version="1">MSEIRSKIWCSNEKLAVFGKVMDVEENLNAGRSGFLTILSHPDIVIVPATSPFVILFARYGIFSKEVEDGCAEPDPRRHGSNPQTYGRFLETSTRKFAVFGKVMDVEKNLNAGLSRSVFITYYTQAAIRSALNFPEPIFLNRESLKISAWRPYGAPDPRNFQTCACSHTFMSSASLRSHRVSHFRKPKECGPGREEAFGLQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZ17</accession>
    <name>E9HZ17_DAPPU</name>
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        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
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    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_67470</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX63013"/>
    <dbReference type="EnsemblMetazoa" id="EFX63013">
        <property type="protein sequence ID" value="EFX63013"/>
        <property type="gene ID" value="DAPPUDRAFT_67470"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_67470"/>
    <dbReference type="eggNOG" id="KOG0261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000487_3_0_1"/>
    <dbReference type="InParanoid" id="E9HZ17"/>
    <dbReference type="OMA" id="DAIMETH"/>
    <dbReference type="OrthoDB" id="591636at2759"/>
    <dbReference type="PhylomeDB" id="E9HZ17"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLA_N" evidence="12">
        <location>
            <begin position="252"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX63013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1391" mass="156246" checksum="3329B38C1364B66F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9I0D0</accession>
    <name>E9I0D0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_336789</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX62550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX62550"/>
        <property type="gene ID" value="DAPPUDRAFT_336789"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_336789"/>
    <dbReference type="HOGENOM" id="CLU_1231035_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9I0D0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX62550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="184" mass="21188" checksum="8FDBBE9A95CCB1C5" modified="2011-04-05" version="1" fragment="single">MEKWTVSRSSVHVSSLFKLLPSHCLEYMTECLLKDHTLQRSIGSKDYLITEDMLDLLLLSPHMKVLDLSQDYLNTGHDLQRNVRIFCLASVRCLLSGTIDEIGYPQMPVLNRVYYSTSDNDIQLSTHIDSSNSDWFNCSPDIACPTEKQPLHSKNFPRVTQILEVQQTGVVDFWDTWIRPMPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9I225</accession>
    <name>E9I225_DAPPU</name>
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        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_120717</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX61955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX61955"/>
    <dbReference type="EnsemblMetazoa" id="EFX61955">
        <property type="protein sequence ID" value="EFX61955"/>
        <property type="gene ID" value="DAPPUDRAFT_120717"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_120717"/>
    <dbReference type="eggNOG" id="KOG1015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074202_0_0_1"/>
    <dbReference type="OrthoDB" id="815681at2759"/>
    <dbReference type="PhylomeDB" id="E9I225"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
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        <property type="entry name" value="Helicase_C"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="PTHR45797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
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        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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            <end position="289"/>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="289" mass="33060" checksum="08DCAD1936846515" modified="2011-04-05" version="1">MKQQSQLLHKLLRGLVQRFDLNVLSPYLPSIFEYVLSVRLSELQIKLYEHFLRYNANASPSRDSQGNRLFSHYHELGHLWAHPKALIGKLSVFSGDNGNDRSSSNAWWSQILLEQEDMTQLKFFIRANSLGKKVLIFSQSLVSLCLIEEFLAAEDRKNRAGLALTDKNPIGLLKLDVDYLRMDGHTTVEKRNSDCNMFNDPMNIRARVFLISTKAGGMGINLTAANRVIIFDASWNPSHDIQSIFRVYSGNPLISGNFPLIKGLDNKNLVTYIAFWLREQWRKRSTSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2E3</accession>
    <name>E9I2E3_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX61837"/>
        <property type="gene ID" value="DAPPUDRAFT_337997"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_337997"/>
    <dbReference type="HOGENOM" id="CLU_3020232_0_0_1"/>
    <dbReference type="OrthoDB" id="15897at6657"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241454" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX61837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="56" mass="5922" checksum="8231650C9028FB24" modified="2011-04-05" version="1" fragment="single">MRLLYALAALLAVLGMAGRANAFCPVGCLCDDETLQVTCDEANLEVIPITLNPSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2W4</accession>
    <name>E9I2W4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_338523"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_055699_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9I2W4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleus"/>
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    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
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        <property type="term" value="F:ubiquitin ligase-substrate adaptor activity"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="319" mass="36387" checksum="23743D11B60E4EE2" modified="2011-04-05" version="1">MNLNNILYSTLNFTDEDILRIVSMDCDDDFLVTMSIAWSDRPGIPCVSTILVRELQSGEVIQRIMGNFSRSCGYETSFKVRFGHGLLISHQVVGEQPNGRLILQDVLKSRLDIWRMANVREIEAKSTVCLVPISKLNVLYPVRIGHDENYIVVHRSDPPRFEIMSTSSLNLTRTIDAFDYCPSVHYKDGLIVSSSAHMDTHTRTCCIIRIWDVETGLCLREIQEPEPGRYSNLNHLVGFTTNYLITVPADLSMLKRVIKIRDLSVAIDLHSNQTSASTVVATIELDRDTSWYDRFIVDDFQLVYFHDQELVVHSFAPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9I665</accession>
    <name>E9I665_DAPPU</name>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="3" type="ORF">DAPPUDRAFT_123889</name>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL736208">
        <property type="protein sequence ID" value="EFX60515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60515">
        <property type="protein sequence ID" value="EFX60515"/>
        <property type="gene ID" value="DAPPUDRAFT_123889"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_123889"/>
    <dbReference type="HOGENOM" id="CLU_812766_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003242175" evidence="2">
        <location>
            <begin position="22"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX60515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="342" mass="38182" checksum="3F1590A81B0D4CC6" modified="2011-04-05" version="1" fragment="single">MHPDFISWVLLILVSTSSVAGAGSSSDEEENGPLQIVTTPSDDDGYITPNSPLVSPHEKSFKFDEDDDEGNDDTEYDFSGLSVWIFNKSAVDFSPSLSEYFTLNTISLTTNQDFNDLVKVMKGYGREQKQGGTSFSFGLYSPSKPGSRFRVNVEESEAPVISSSPARTPEQEIQLGRGNCGKNANGFRQFSRKHIIRLTTSNWNPDHHPTLAFYFAPAKRGHEPVSTATFFFMPATELLDYHLLENSKYGDVFKNEDGFSGCVSAGMCSPNYQKSTGHLLLPMDCTPDSAQPEKDLPGNALLFEHVQQFVADRKIMSLPVTDYLRVLFDWMRRKKQAEANHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9I6T2</accession>
    <name>E9I6T2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL736676">
        <property type="protein sequence ID" value="EFX60298.1"/>
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    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_343527"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_343527"/>
    <dbReference type="HOGENOM" id="CLU_782063_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="355" mass="35596" checksum="53D02CACFBD13C42" modified="2011-04-05" version="1" fragment="single">FGAADLGEIDVGGAKADIAAVFAQAGRVAHAEAALEVFVPRAAEQGAAALRHGAEKHGGGAGRCAQLAVLLQLHGVVEGGAALARQDDLAALFVAHRTEHIAIARGDEHLAGVGEALAHRQPGVAQQDAGARGIGPGTLGQRGRAVQVDHAAAAVEQRTGYLQPALVDLEHAQVAVAGAAQLQRLAGLHQHAATGLVEQVGLQACALARATGHAAHEAGVAQALAHHQTVGLHCALVDHQAREAACAGQDAARADHHGVRRVEGASGHLQCHQAGAGADLQGLQLHGAAGAGDAQAVCCIHDHVMHVGGVHAQRPVGGVFPTAAGGVSPVQFGGEQKDALRAVGEEGLIGHLPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9I7F6</accession>
    <name>E9I7F6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_125602</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL737192">
        <property type="protein sequence ID" value="EFX60074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_125602"/>
    <dbReference type="HOGENOM" id="CLU_945165_0_0_1"/>
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        </location>
    </feature>
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        </location>
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        </source>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="296" mass="32252" checksum="62A58F09B3D99BAF" modified="2011-04-05" version="1" fragment="single">ADGSAPQSVRARWREEPRDARAGDLDGARRARLDRATRRRRGDPTAERLPRLLAAEAPVRAAHWRSYAPLPHHRRPPRAPRLDAHEGGGALARALRPRAVCPRRAAVRIRRGARRPDDARLAARRLHGARARVARRERGARGRASAPRSRRGRSKPADAPPRGARTARRGPRDGLGLRASQRAAFGRAPSSRNIGRGTGRVSRVAASSLERLLHRSSSSSRPDAVERRGPRGFGVAVCACCRLASPSCAFPAVASTSTTSPSMREIRSWHMRGSTSPRRARTSSGSSRRSSTSTRA</sequence>
</entry>
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    <name>E9FQT4_DAPPU</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="199" mass="22323" checksum="F8F2331BDDF42D53" modified="2011-04-05" version="1">MEPAGMSGIRGTQRPRSLCDSKLLSVTPHGLHHHHLVQQQSSRDQQQQQQLVVKRPPPPLPLSPPRAEPSKYRGSWPSMIYYGGGHDQLQQDADAFVRLEQQKRAPSMAGLMNTTVPQRLSPKSHITKTADSTPGDVIGQVGKGSRAKKKPTKRTARAIIHNQMCRDLPAMEEPFKRRACIEREAGSAFRNSNRFLLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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    </protein>
    <gene>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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        </lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DAPPUDRAFT_219990"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR34343"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="243"/>
            <end position="277"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="392"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="533" mass="61401" checksum="35310E014D15E771" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRZ3</accession>
    <name>E9FRZ3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial ribosomal protein-like protein S26 CG7354-PA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_232128</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Vos H."/>
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                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX90400">
        <property type="protein sequence ID" value="EFX90400"/>
        <property type="gene ID" value="DAPPUDRAFT_232128"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_232128"/>
    <dbReference type="eggNOG" id="KOG4691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104778_1_0_1"/>
    <dbReference type="InParanoid" id="E9FRZ3"/>
    <dbReference type="OMA" id="RKPRWLP"/>
    <dbReference type="OrthoDB" id="1623955at2759"/>
    <dbReference type="PhylomeDB" id="E9FRZ3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026140">
        <property type="entry name" value="MRPS26"/>
    </dbReference>
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        <property type="entry name" value="PTHR21035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14943">
        <property type="entry name" value="MRP-S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX90400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="176" mass="21078" checksum="1968E02F5CDDB0EA" modified="2011-04-05" version="1">MFRIAPKKFIPADEKAEVKRLYDNYFHQMKSLRHYFFEQSLEQAESGEVAQMKHRLEEEEHIRLMEENRLENEKTAKLREEKLKIQAEKTRENILASLINKEEETRQYEIQIEAFLEKQKATPFIQAENIEKAIEEALANPVDFNFAIDLDGYVYRGRETAIEKIPEEERERLRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSA3</accession>
    <name>E9FSA3_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_33380</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90355"/>
    <dbReference type="EnsemblMetazoa" id="EFX90355">
        <property type="protein sequence ID" value="EFX90355"/>
        <property type="gene ID" value="DAPPUDRAFT_33380"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_33380"/>
    <dbReference type="eggNOG" id="ENOG502QR0N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077763_0_0_1"/>
    <dbReference type="InParanoid" id="E9FSA3"/>
    <dbReference type="OMA" id="THTNAIC"/>
    <dbReference type="OrthoDB" id="166859at2759"/>
    <dbReference type="PhylomeDB" id="E9FSA3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040346">
        <property type="entry name" value="GEX1/Brambleberry"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33538">
        <property type="entry name" value="PTHR33538"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX90355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="258" mass="29647" checksum="B57AA89D3CB38625" modified="2011-04-05" version="1" fragment="single">ALKDEKQLQEGQLNYNLVVRDSQMPRYGSCWKNALKELETGCKHLTDDLQRWLALQFTNCFLEKAGQTTYPCDNNDDITVCLSQMNNNGFTAFTNFFTHTQSMCYFLQTQVWQEETENTVAKLTDNSMKVVQTLEDTNELQDAILEAQRKSLSQQERLLESSSQLGIALDMSKDNVKDMLEEFRSSTSEQRNMIFEVFDRLSKLQNLVLGEVSGFYSLIFYPTALLTVYLLTSTSRTAAARFWLFVLFGCSLALERCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9FU87</accession>
    <name>E9FU87_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_9105</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX89503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89503">
        <property type="protein sequence ID" value="EFX89503"/>
        <property type="gene ID" value="DAPPUDRAFT_9105"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_9105"/>
    <dbReference type="HOGENOM" id="CLU_164133_4_2_1"/>
    <dbReference type="InParanoid" id="E9FU87"/>
    <dbReference type="OrthoDB" id="1586232at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX89503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="57" mass="6502" checksum="83A9086F489FE383" modified="2011-04-05" version="1" fragment="single">NELCNLPPIDSDRSECEAYIPSWTFQPNSGRCENYVYGGCFKTKNLFETEEECQAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUB4</accession>
    <name>E9FUB4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88694">
        <property type="protein sequence ID" value="EFX88694"/>
        <property type="gene ID" value="DAPPUDRAFT_234000"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_234000"/>
    <dbReference type="HOGENOM" id="CLU_2308821_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="EFX88694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="100" mass="11016" checksum="61279E25D787E774" modified="2011-04-05" version="1">MTSDKEVNDPLSPLSDTGDFSSLFQGLEKDNVTKKPTALTLGTNSSGYAGSTVIRSFYSVYLLHYWILTVYADGNIFDRHEGFQLFAGIPGRDFPVSEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUJ0</accession>
    <name>E9FUJ0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 10">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">EOG090X0A33</name>
        <name evidence="13" type="ORF">DAPPUDRAFT_191310</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TCO</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C12 family. BAP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 10"/>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015394">
        <property type="protein sequence ID" value="SVE85013.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88738"/>
    <dbReference type="MEROPS" id="C12.005"/>
    <dbReference type="EnsemblMetazoa" id="EFX88738">
        <property type="protein sequence ID" value="EFX88738"/>
        <property type="gene ID" value="DAPPUDRAFT_191310"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_191310"/>
    <dbReference type="eggNOG" id="KOG2778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018316_0_1_1"/>
    <dbReference type="OMA" id="DGAGNWC"/>
    <dbReference type="OrthoDB" id="1363547at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="PTHR10589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH_1" evidence="11">
        <location>
            <begin position="7"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="UCH_C" evidence="12">
        <location>
            <begin position="252"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX88738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="SVE85013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="318" mass="36440" checksum="1CEE2BB7B27268FC" modified="2011-04-05" version="1">MADAGNWCLIESDPGVFSELIRDFEVQGVQVEELWSLDPEQFDNLKPIHGLIFLFKWVPNEEVVGTVVQDSRLDKIFFAKQVINNACATQAIISILLNCKHPDLHLGPTLGEFKEFTQAFDANMKGLALSNSDTIRSVHNSFARQTLFEFDSKASSKDDDTFHFVGYVPVDGRLYELDGLKEGPIDLGAVPAETDWIDVVRPIIEKRIQRYSEGEIHFNLMAIVPDRKLAWQKEIERLQSQPVVSTDMQTEIQRLLMLCEEEESKRKRQKIENVRRKHNYLPLIVQLLRMLGEKGQLLPLYEKAKQRAVAKTTTQKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUQ5</accession>
    <name>E9FUQ5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_311119</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88883">
        <property type="protein sequence ID" value="EFX88883"/>
        <property type="gene ID" value="DAPPUDRAFT_311119"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_311119"/>
    <dbReference type="eggNOG" id="ENOG502RTD1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_301329_0_0_1"/>
    <dbReference type="OMA" id="QEQSYAP"/>
    <dbReference type="OrthoDB" id="1644796at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236822" evidence="2">
        <location>
            <begin position="41"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="960"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX88883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="992" mass="103385" checksum="A92769CFD39B1120" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9FVF7</accession>
    <name>E9FVF7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_233681</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88546">
        <property type="protein sequence ID" value="EFX88546"/>
        <property type="gene ID" value="DAPPUDRAFT_233681"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_233681"/>
    <dbReference type="HOGENOM" id="CLU_2415520_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="92" mass="9836" checksum="FE3F08788BBC64B9" modified="2011-04-05" version="1">MSSTNSTTKSAGTKASGLLIVDPLENNRPNGSADEDHQISKLIRQQFLSMALRCDSSKMAISAAPTTFIRVEATKAVLALSQPDVGLIKFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9FVZ2</accession>
    <name>E9FVZ2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_191173</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88635"/>
    <dbReference type="EnsemblMetazoa" id="EFX88635">
        <property type="protein sequence ID" value="EFX88635"/>
        <property type="gene ID" value="DAPPUDRAFT_191173"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_191173"/>
    <dbReference type="eggNOG" id="KOG4133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049366_2_1_1"/>
    <dbReference type="InParanoid" id="E9FVZ2"/>
    <dbReference type="OMA" id="TVAWCNP"/>
    <dbReference type="OrthoDB" id="1621103at2759"/>
    <dbReference type="PhylomeDB" id="E9FVZ2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="tRNA_splic_SEN34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="SSF53032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_int_endo" evidence="4">
        <location>
            <begin position="180"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX88635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="270" mass="31409" checksum="CFFF31F0297B8C2C" modified="2011-04-05" version="1">MKMIELCSCNGSFLVWNFEDVHRLRSEHRIVGNFIGCLPSLPRQDQMLGLPMELMIEEVYHLNSRGIVKLIEFKQLNLPAQGQNKEKIEEMHKASFADQEVIFKVERTKQLLQMADKIIEGKRRKMNGKTVDEKIALQEEIDKIPKMSKDLMMVQIFTRPHWTCQGESVLPLDFHVRPTLRCKVFSDLWEKGYYITSGEKFGGDFLVYPGDPLKFHSHFIAVCVEEHQMLTPWFLIQKGRLGTSVKKTVLMCSLDENDEVNYQSVNWNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9FX37</accession>
    <name>E9FX37_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetratricopeptide repeat protein 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_305649</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell projection</location>
            <location evidence="1 7">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TTC30/dfy-1/fleer family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88330"/>
    <dbReference type="EnsemblMetazoa" id="EFX88330">
        <property type="protein sequence ID" value="EFX88330"/>
        <property type="gene ID" value="DAPPUDRAFT_305649"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305649"/>
    <dbReference type="eggNOG" id="KOG4340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023760_0_0_1"/>
    <dbReference type="InParanoid" id="E9FX37"/>
    <dbReference type="OMA" id="MRNHPEL"/>
    <dbReference type="OrthoDB" id="247838at2759"/>
    <dbReference type="PhylomeDB" id="E9FX37"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
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    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039941">
        <property type="entry name" value="TT30"/>
    </dbReference>
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        <property type="entry name" value="PTHR20931"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="6 7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 7" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX88330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="663" mass="75152" checksum="9FF1BAA2801A2F98" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXT2</accession>
    <name>E9FXT2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_311747</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88152">
        <property type="protein sequence ID" value="EFX88152"/>
        <property type="gene ID" value="DAPPUDRAFT_311747"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_311747"/>
    <dbReference type="eggNOG" id="ENOG502S88E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065450_3_0_1"/>
    <dbReference type="InParanoid" id="E9FXT2"/>
    <dbReference type="OMA" id="MYKFIFI"/>
    <dbReference type="OrthoDB" id="1459720at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012361671" evidence="3">
        <location>
            <begin position="16"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX88152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="124" mass="13021" checksum="8242270A7EF4449D" modified="2011-04-05" version="1">MKIVIVVALLALVAAQKDKEPVAIVSSNSEMNADGSYTYAFETADGTKVEESGSQKQVGPKPEDIGTVSKGSYSYTSPDGVVITVNWTADENGFQATGDHLPTPPPMPEHVVKMLADLKAAGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZN6</accession>
    <name>E9FZN6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">60S ribosomal protein L41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_312612</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL41 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87089">
        <property type="protein sequence ID" value="EFX87089"/>
        <property type="gene ID" value="DAPPUDRAFT_312612"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312612"/>
    <dbReference type="HOGENOM" id="CLU_2544906_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007836">
        <property type="entry name" value="Ribosomal_L41"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05162">
        <property type="entry name" value="Ribosomal_L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX87089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="83" mass="9858" checksum="1A20F274F8EC9F68" modified="2011-04-05" version="1">MLYPTQHKVVVLSAGLLRVLAMMFTAKLSALDDSKHQYLHCVTLNHSSQQSSKESDCNMRAKWRKKRMRRLKRKRRKMRARSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9G002</accession>
    <name>E9G002_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_43739</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87140"/>
    <dbReference type="EnsemblMetazoa" id="EFX87140">
        <property type="protein sequence ID" value="EFX87140"/>
        <property type="gene ID" value="DAPPUDRAFT_43739"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_43739"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_13_1_1"/>
    <dbReference type="InParanoid" id="E9G002"/>
    <dbReference type="OMA" id="THEYDIG"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="PhylomeDB" id="E9G002"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX87140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="194" mass="21724" checksum="AACC38A3F3E43944" modified="2011-04-05" version="1" fragment="single">ALLQFDEMSQRYKLACGGSLISATKILTAAHCVIQNNSIPAFDKLVVKLGMHFLKEKADDAELTMRINQIEIHENYDQLTKFNDIAIVTLESPVEFTDRISTVCLPKDCHGGANSGYARALGWGNAKKGERNSDVLRHTTTKMMSNEACIQRNASRQIELADHMICALATRDFCQVDGNTLARLIIKFYFEHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9G0H2</accession>
    <name>E9G0H2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pept_C1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_235664</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C01.092"/>
    <dbReference type="EnsemblMetazoa" id="EFX87401">
        <property type="protein sequence ID" value="EFX87401"/>
        <property type="gene ID" value="DAPPUDRAFT_235664"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_235664"/>
    <dbReference type="HOGENOM" id="CLU_1679730_0_0_1"/>
    <dbReference type="OrthoDB" id="1275401at2759"/>
    <dbReference type="PhylomeDB" id="E9G0H2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="3">
        <location>
            <begin position="102"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX87401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="157" mass="17711" checksum="4B839293D9C5A923" modified="2011-04-05" version="1">MTKNKTLRNEMKFTVKFHFQEIAVIAVDTERIPFLLSSAPASVPPPFRGLGAFAAVAPIEFNYCKKHKQTPIVLRSCPTPFWFFLASARVLIFSYIPVNNAVAMQRDGVYDVTRIVITWMSITLWTVIVGWGNQGGLDYWIVRNSWGTGWGDSGYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1Q5</accession>
    <name>E9G1Q5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_236308</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86538">
        <property type="protein sequence ID" value="EFX86538"/>
        <property type="gene ID" value="DAPPUDRAFT_236308"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_236308"/>
    <dbReference type="HOGENOM" id="CLU_603076_0_0_1"/>
    <dbReference type="OMA" id="IFPNAND"/>
    <dbReference type="OrthoDB" id="1876951at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX86538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="454" mass="49468" checksum="2CB40AF8225CF2A9" modified="2011-04-05" version="1">MVPLSFHKPGKKSKESTYIVLPPLPSANQAKSVGSQGPHHPIYISKQDTAFHQPGPPYSQTQSAPTGPAQNTQPSSFSPQQPTSYEAPPNSPVSPNAESEHHEDAVSPPAHSDSRYSKWFSKLKRRKSNQPQPEKPQHEPETFQDKPPNQASGAIPETIFYYQNGSPYNQPSATPNQPGNGQSPTFLRQPQIANSPSQPAPARPANNQPQSAPPTHPGVFSSQINFDSRDNFPHSVIEVLEQPPPSGNLYSKLIKKMKRNKTQKPEPVKVVSQAEPIFSPIQTENIPPSDPAPYRPLQSPPQQQPPPRPASANIVKPQSTATNLPSDPALYRRPQLPSQLSPPGPANIVKPQPTASPVPHSSHHQAPNKPARPEAATPPAGHSHTKRPPATVEKQPLFPESETFFSSANRPDFGGPTPFQKQTENKGTNESSDGFFEFGIFPNANDFFEQNFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3D3</accession>
    <name>E9G3D3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_222344</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX86007.1"/>
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    <dbReference type="EnsemblMetazoa" id="EFX86007">
        <property type="protein sequence ID" value="EFX86007"/>
        <property type="gene ID" value="DAPPUDRAFT_222344"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_222344"/>
    <dbReference type="eggNOG" id="KOG3587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037794_1_1_1"/>
    <dbReference type="InParanoid" id="E9G3D3"/>
    <dbReference type="OMA" id="HYGGRIF"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="CDD" id="cd00070">
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        <property type="entry name" value="ConA-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
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    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="PTHR11346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
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        <property type="entry name" value="Gal-bind_lectin"/>
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    </dbReference>
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        <property type="entry name" value="SSF49899"/>
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        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="2">
        <location>
            <begin position="169"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="303" mass="34011" checksum="C4EDBE507CC7E53C" modified="2011-04-05" version="1">MNTTINNPVIPCVMSLPGGRLQQGNLIVIHGQPTYNSNRFCVSLVCGQQRELGEIAFQLTSHFDTSWVIRNSKLNKEWGVEEGTTTHKFPFKRLQPFKIEIFTSPSSYLITVDGNHHCEYIHRVSYSEANTLQITGDVQVSMIEFRSANTFPTFPSSNRLNVAYPPLPFASLINGPLSVGNEIQVHGQVKPHPNRFHINLQQGCQSYPHPTMVFHFNPRYEGGQRTIVMNSFIGSWGSEQRVAVPRNLLPGNNFVLAIRRQPSYFEVSVNGSVIATYNHRIAADMVDSVSIDGDVIIHKVVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3P7</accession>
    <name>E9G3P7_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_309088</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="523" mass="59488" checksum="F8665141633C5115" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_237773</name>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX85266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_237773"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_511192_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="2">
        <location>
            <begin position="318"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX85266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="459" mass="50532" checksum="8CB59481E7A43810" modified="2011-04-05" version="1">MSVQVYEDNGRFALINAQMPDHNGVFVTYTLVVPDFWLMAVDNKNGNKETYCAYKNCKDINVAVKGREVPRTDWPTYVAVVRKIFENFNSARQQLALAVEQTDLSTEEAAEEGRGKRPKRPPASPELGSAPVGVGEDSQLDSQLINSPTLSDSSDNEPIPNPGPVSRRLLPAVAKRPPFPSTTNRPATTGVVSRPSTSANTNQRFSSGVSTTPSSANNRQQFVIPDVNRRPPLLARPTTSDGIEDEALGENRPVLLAIEERPVRHARINGIENIDPIRIYKGILKLTIEVNELKDLITVLTKICLSKADCHTEGSETLDEIPICSVESFKAFEIKLKDSADKYSSLVKFIKFLGGNSEGDAVQRSWEKLTTIDCRAQCNFNGVRRGLNQKHPLKGSVITAALFAGIRANSQFANCTDATLEHETIRCFVRAPEAVRRRNLAAAAVPVEADDAERRPQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9G4S7</accession>
    <name>E9G4S7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_300423</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Integrator subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85507"/>
    <dbReference type="EnsemblMetazoa" id="EFX85507">
        <property type="protein sequence ID" value="EFX85507"/>
        <property type="gene ID" value="DAPPUDRAFT_300423"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300423"/>
    <dbReference type="eggNOG" id="ENOG502QSP2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007707_0_0_1"/>
    <dbReference type="InParanoid" id="E9G4S7"/>
    <dbReference type="OMA" id="SRTFLKH"/>
    <dbReference type="OrthoDB" id="173270at2759"/>
    <dbReference type="PhylomeDB" id="E9G4S7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026236">
        <property type="entry name" value="Int2_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029321">
        <property type="entry name" value="INTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608">
        <property type="entry name" value="PTHR28608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14750">
        <property type="entry name" value="INTS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02105">
        <property type="entry name" value="INTSUBUNIT2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1175"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX85507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1263" mass="141198" checksum="A0B37AE090B3B0DA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7P5</accession>
    <name>E9G7P5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_28540</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84512">
        <property type="protein sequence ID" value="EFX84512"/>
        <property type="gene ID" value="DAPPUDRAFT_28540"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_28540"/>
    <dbReference type="HOGENOM" id="CLU_2765077_0_0_1"/>
    <dbReference type="InParanoid" id="E9G7P5"/>
    <dbReference type="OrthoDB" id="619766at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX84512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="70" mass="8246" checksum="F2CBFDC8CFE236C8" modified="2011-04-05" version="1" fragment="single">EKKYEYVIQAIEHLKHRKARPDLEGIKNYAFRRHGIDPVTCCADVDELIENEQIIKVEFKGRTSYRNAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8A4</accession>
    <name>E9G8A4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Flap endonuclease 1</fullName>
            <shortName evidence="12">FEN-1</shortName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Fen1</name>
        <name evidence="15" type="ORF">DAPPUDRAFT_47502</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with PCNA. Three molecules of Fen1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
            <location evidence="12">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
            <location evidence="12">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="12">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84308"/>
    <dbReference type="EnsemblMetazoa" id="EFX84308">
        <property type="protein sequence ID" value="EFX84308"/>
        <property type="gene ID" value="DAPPUDRAFT_47502"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_47502"/>
    <dbReference type="eggNOG" id="KOG2519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032444_2_0_1"/>
    <dbReference type="InParanoid" id="E9G8A4"/>
    <dbReference type="OMA" id="GSQDYDS"/>
    <dbReference type="OrthoDB" id="1094524at2759"/>
    <dbReference type="PhylomeDB" id="E9G8A4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="PTHR11081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPGN" evidence="14">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="XPGI" evidence="13">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-domain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="I-domain" evidence="12">
        <location>
            <begin position="122"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with PCNA" evidence="12">
        <location>
            <begin position="336"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFX84308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="374" mass="41882" checksum="0F6AB46849EF7121" modified="2011-04-05" version="1">MGIKGLTQVIGDTAPTAIKENEIKNYFGRKVAIDASMSIYQFLIAVRSEGAMLTSADGETTSHLMGIFYRTIRMVDNGIKPVYVFDGKPPDMKGGELTKRAEKREEASKQLVLATDAGDAVEMEKMNKRLVKVNKGHTDECKQLLTLMGIPYVEAPCEAEAQCAALVKAGKVYATATEDMDSLTFGSNVLLRYLTYSEAKKMPIKEFHLDKILDGLSYTMDEFIDLCIMLGCDYCDTIKGIGAKRAKELIDKHRCIEKVIENLDTKKYTVPENWPYQEARRLFKTPDVADAETLDLKWTQPDEEGLVKFMCGDKNFNEERIRSGAKKLCKAKTGQTQGRLDSFFKVLPSSKPSTPSTPASKRKVGCIIYLFLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9W1</accession>
    <name>E9G9W1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cysteine protease</fullName>
            <ecNumber evidence="17">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DAPPUDRAFT_194862</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine</text>
            <dbReference type="Rhea" id="RHEA:67576"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="Rhea" id="RHEA-COMP:17326"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172942"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67577"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="17"/>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83634"/>
    <dbReference type="MEROPS" id="C54.A04"/>
    <dbReference type="EnsemblMetazoa" id="EFX83634">
        <property type="protein sequence ID" value="EFX83634"/>
        <property type="gene ID" value="DAPPUDRAFT_194862"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_194862"/>
    <dbReference type="eggNOG" id="KOG2674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021259_0_0_1"/>
    <dbReference type="InParanoid" id="E9G9W1"/>
    <dbReference type="OMA" id="CHTRRIR"/>
    <dbReference type="OrthoDB" id="431748at2759"/>
    <dbReference type="PhylomeDB" id="E9G9W1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032916">
        <property type="entry name" value="ATG4B_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="PTHR22624"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF39">
        <property type="entry name" value="PTHR22624:SF39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 17" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240144" description="Cysteine protease" evidence="18">
        <location>
            <begin position="23"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR632916-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFX83634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="389" mass="44026" checksum="00B1CBA6B266A1E8" modified="2011-04-05" version="1">MRCVILVIKLLISIFKILVVNTKRMLEACEAFVTYESGIILERQGFEVNDEPVWILGREYDTKTKLDELNSDVKSRLLLTYRRNFPPIGDSGMTSDRGWGCMLRCGQMVVAQALINQHLGRQPFWPVGDDQRTTESYKKILKLFEDKKTAVYSIHQLAQMGVSEGKEIGQWFGPNTVAQVLKKLSEYDEWSALKIHVAMDNAVVIEEIEQLCHKKITPTETSTWSPLLLVVPLRLGLLNINPIYIDSLKACLQMPQSIGMIGGKPSQALYFIGYVGDDVVFLDPHLTQNAIDLDEDEFDDSSYHPATCARISFQSMDPSLAVCFSCTTHSEWKDLLRQFKDMSEIGKKQNLFEVCSQRQAEWHPSTTDLADEAIALDSADSEDEFEILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9Y1</accession>
    <name>E9G9Y1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_100270</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83646"/>
    <dbReference type="EnsemblMetazoa" id="EFX83646">
        <property type="protein sequence ID" value="EFX83646"/>
        <property type="gene ID" value="DAPPUDRAFT_100270"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_100270"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_704496_0_0_1"/>
    <dbReference type="InParanoid" id="E9G9Y1"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="PhylomeDB" id="E9G9Y1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241004" description="Peptidase S1 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="57"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX83646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="392" mass="44004" checksum="66F07AED04D3A086" modified="2011-04-05" version="1">MSAKFLEDLQGSLALVLLTAAGFTFVSDDSQTFDNRQSYDRALLRWFAEWPTTWRQAKSSVERETAPNEFPWQAILLVVKSNETNFCRGSLIADRWILTTASCLEVSSGQKLKVLNVYLGAHNISATSEVNRKEYWGNETFIHPNWNPTTEAGDIALDNLSTVVEYTKCIRLSVHASGICLPKPSEPDHVNQNVTVTGVDVQLVASCKANRRVYNGYKVYIHPEWQARDIALIKLYNIVTYTRNYTNVPLDFVSELRQVVNSQVTVTGWGSFTLSPVLRKVTVPVISNSYPMQQLLRQHCRNKVIMGEPLIFRQSNSRWKQIGIVSFVSSQGCQTGYPYGYKRLGSYLTWVQNVMSSYSGSSSTTTTPSPSSSSQTSTLLSLVISLCFVMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAE2</accession>
    <name>E9GAE2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_239907</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83538">
        <property type="protein sequence ID" value="EFX83538"/>
        <property type="gene ID" value="DAPPUDRAFT_239907"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_239907"/>
    <dbReference type="HOGENOM" id="CLU_2252695_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236807" evidence="2">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX83538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="104" mass="9730" checksum="DAE47D4CDA04EE4E" modified="2011-04-05" version="1">MVSFKIALLFAVLVAVAYALEAANEDLELAESKGKKHMSSGGSSYGSSYGGSSYGSGGSSYGGGKGKGKGGKGKGKGGSSGGYGGSSGGYGGSSGGYGGIGGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAV3</accession>
    <name>E9GAV3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ascorbate ferrireductase (transmembrane)</fullName>
            <ecNumber evidence="7">7.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_301866</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <cofactor evidence="1">
            <name>heme b</name>
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        </cofactor>
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        <property type="gene ID" value="DAPPUDRAFT_301866"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502T7X4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072399_3_0_1"/>
    <dbReference type="InParanoid" id="E9GAV3"/>
    <dbReference type="OMA" id="WFQATVK"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </feature>
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        </location>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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        <submittedName>
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    </protein>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX83459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="410" mass="46707" checksum="6D0A187A8CE81C2A" modified="2011-04-05" version="1">MSTDISRRILQVHAFGRNNFKLGTLYDARTDEVVPTEFSLWKQNDLKTTDVTHNTQTHCTVIALDKLSEKLKRLEVGGSLQISILSGLTNLKGPAHFLNRKQKTLLESIVHVRCHHYTVVQSLTDEQFSIGKACYVDISTRTGYSDSATHVITKIQYGSESTFTFRKLIYPAQVKQIVDDHLVACASNVVNALLGKTKTLLDDPNINSSEIVECHFEGDFILPENVATPTTYRETLVFASQFREILSRSMAKSVENEPLGVPCLVSLFPLVNLSGVESVPRLRQEISNAVASRCVRLMEDYEDMEDEIETLLKNPLVAELSPLFEKLRVFQQLFDAFRADLKAKLRDLLINIRSGFDDVASLGQLLNRFYNQQFPFNPRRLGLWLEEKHEELCMVKRFRDQLSAEKLHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9GB01</accession>
    <name>E9GB01_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_301953</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the CAP family.</text>
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        <property type="gene ID" value="DAPPUDRAFT_301953"/>
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    <dbReference type="PhylomeDB" id="E9GB01"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045761">
        <property type="term" value="P:regulation of adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
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        <property type="entry name" value="CAP/MinC_C"/>
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        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028417">
        <property type="entry name" value="CAP_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="PTHR10652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="SSF101278"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF69340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01089">
        <property type="entry name" value="CAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="3">
        <location>
            <begin position="328"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX83457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="483" mass="51805" checksum="E94487C980307D10" modified="2011-04-05" version="1">MASAAELSLIVQRLETVASKLESTVLGAQGSTTTMPEEALAPSVLAFDEIVAGPFAAYLKCSKVIGGDVAQHADMAQQGFKDQRHFLIVASRSKAPVEADLVKLLAPTSQAIQGIQSFREKNRTSPLFNHLSAISESIPALGWVTVAPAPGPYIKEMNDAGQFYTNRVLKDWKDKDKNHVDWVRAWVQVLTDLQAFVKQHHTTGLVWNAKGGDAVQNAGKTAPTSKAGGPPPPPGPPPPPMPAGDLFAEESGAGSGGDEQSRAQLFAALNKGEDVTKGLKKVTADMQTHKNPSLRSGPAPFTKPSVAPKPIGSVAASSPAMQKAVERPPRKELEGKKWMIEYQKNQTGLVITDTEMHQVVYIFKCEGSTIQVKGKVNSIVLDSCKKTSIVLDSVVSSVEFVNCQSVQMQVLTKVPTISIDKTDGCQIYLNQASLDVSIVSAKSSEMNVLVPKADGDYVEYPIPEQFKTTYNGKGLTTIISEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E9GG04</accession>
    <name>E9GG04_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Alpha-amylase</fullName>
            <ecNumber evidence="6 14">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">AMY</name>
        <name evidence="18" type="ORF">DAPPUDRAFT_347603</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="6 14"/>
    <dbReference type="EMBL" id="GL732543">
        <property type="protein sequence ID" value="EFX81580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81580"/>
    <dbReference type="EnsemblMetazoa" id="EFX81580">
        <property type="protein sequence ID" value="EFX81580"/>
        <property type="gene ID" value="DAPPUDRAFT_347603"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_347603"/>
    <dbReference type="eggNOG" id="KOG2212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013336_2_1_1"/>
    <dbReference type="InParanoid" id="E9GG04"/>
    <dbReference type="OMA" id="HDNQRGD"/>
    <dbReference type="OrthoDB" id="665362at2759"/>
    <dbReference type="PhylomeDB" id="E9GG04"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0868">Chloride</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240966" description="Alpha-amylase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="17">
        <location>
            <begin position="30"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy_C" evidence="16">
        <location>
            <begin position="424"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFX81580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="513" mass="56849" checksum="CA40E308A1D8672F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9GGB2</accession>
    <name>E9GGB2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_224227</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732543">
        <property type="protein sequence ID" value="EFX81370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81370"/>
    <dbReference type="EnsemblMetazoa" id="EFX81370">
        <property type="protein sequence ID" value="EFX81370"/>
        <property type="gene ID" value="DAPPUDRAFT_224227"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_224227"/>
    <dbReference type="eggNOG" id="ENOG502S83W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126877_0_1_1"/>
    <dbReference type="InParanoid" id="E9GGB2"/>
    <dbReference type="OMA" id="GKGDAWS"/>
    <dbReference type="OrthoDB" id="1538520at2759"/>
    <dbReference type="PhylomeDB" id="E9GGB2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090503">
        <property type="term" value="P:RNA phosphodiester bond hydrolysis, exonucleolytic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038838">
        <property type="entry name" value="TRIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34753">
        <property type="entry name" value="PTHR34753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="171" mass="19038" checksum="26D910123508E133" modified="2011-04-05" version="1">MASPREEGELLESSSDSSDEDDSEEEPSGKPGPTAVKFKNDGSFLEMFKKMQENYQTQVPEKAVHEQQLVKDTDTSSSAEKKCSTKKEEEPAASAASPQPVQQKKPGLMSIVGKRRGGKSLPVGVVKKQKRPEEEEESSGKTDAWSQYMSEVKKYKERLGDEEEKNRPLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIA7</accession>
    <name>E9GIA7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_303909</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732546">
        <property type="protein sequence ID" value="EFX80803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80803">
        <property type="protein sequence ID" value="EFX80803"/>
        <property type="gene ID" value="DAPPUDRAFT_303909"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303909"/>
    <dbReference type="HOGENOM" id="CLU_2514945_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="85" mass="9564" checksum="1F2FF3A87144859A" modified="2011-04-05" version="1">MNLPFSSSSMSLLFIWGDIAFLSVTSILFDYIRRVVSFLSQQNRICYLFVCYVEEPILGILYLGCISGIVKQNTYNSSTGSGFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GID9</accession>
    <name>E9GID9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_103106</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732546">
        <property type="protein sequence ID" value="EFX80660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80660">
        <property type="protein sequence ID" value="EFX80660"/>
        <property type="gene ID" value="DAPPUDRAFT_103106"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_103106"/>
    <dbReference type="HOGENOM" id="CLU_2114932_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="115" mass="11598" checksum="B51156246286B58A" modified="2011-04-05" version="1" fragment="single">AVVVVVAAAVVAGVEPRRVAAAADERAAPEVVEMSKDDGGDDKDGPSCWNEADNFAEAKSCEVAVQGTVASDGDGGGKDDEADGVTGNPNADRGNSLMHDKDSPAANLISQTKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJ36</accession>
    <name>E9GJ36_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ferrochelatase</fullName>
            <ecNumber evidence="8">4.99.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_128379</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.1" evidence="8"/>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80553"/>
    <dbReference type="EnsemblMetazoa" id="EFX80553">
        <property type="protein sequence ID" value="EFX80553"/>
        <property type="gene ID" value="DAPPUDRAFT_128379"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_128379"/>
    <dbReference type="eggNOG" id="KOG1321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018884_1_0_1"/>
    <dbReference type="InParanoid" id="E9GJ36"/>
    <dbReference type="OMA" id="LGDPYHC"/>
    <dbReference type="OrthoDB" id="1003638at2759"/>
    <dbReference type="PhylomeDB" id="E9GJ36"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX80553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="348" mass="39370" checksum="43A1C23482953642" modified="2011-04-05" version="1">MGGPSTLPEVGDFLKNLFMDRDIIQLPFQSVLGPLIAKRRTPDIQEKYGQIGGGSPILKWTRKQGDMMCAVLDKICPESAPHKAYVGFRYANPLTEITLEQMEKDNLERAIAFTQYPHYSCTTTGSSMNAIYKYYAERNITTKLNWSVIDRWGTHPLLVDAFVHLIEKELESIDPEIRDQVIILFSAHSLPLRTVNRGDPYPAEVGATVQLIMSKLNHANPYRLVWQSKVGPLPWLEPATDKAIESYIKSGKKHFILVPIAFTSDHIETLHELDIEYGEDLAKKLGVETYRRLPALNDHPIFIEALADLVSNHLKKGPRVTGQLLSRCPMCVNETCGKCKNWFSTMCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKE4</accession>
    <name>E9GKE4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_244187</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732549">
        <property type="protein sequence ID" value="EFX80080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80080">
        <property type="protein sequence ID" value="EFX80080"/>
        <property type="gene ID" value="DAPPUDRAFT_244187"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_244187"/>
    <dbReference type="HOGENOM" id="CLU_1706041_0_0_1"/>
    <dbReference type="OrthoDB" id="1791603at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="154" mass="16867" checksum="EB96F02CAE144124" modified="2011-04-05" version="1">MVQEIISSQQSPEQELSVSVNEGASKVDQISNPSKDEDSYCEHEQLTHMESIYTPHSPEQLVTPTIYEPASKVDLISDPSLVADGFVEHEHSSMNENSTESIAAPHSPEQLVTTTVHKPASEDDLTSHPQPVEDGYCEHEQLTPIESIAASTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKM8</accession>
    <name>E9GKM8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_212220</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732549">
        <property type="protein sequence ID" value="EFX80034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80034"/>
    <dbReference type="EnsemblMetazoa" id="EFX80034">
        <property type="protein sequence ID" value="EFX80034"/>
        <property type="gene ID" value="DAPPUDRAFT_212220"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_212220"/>
    <dbReference type="eggNOG" id="KOG1077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003824_1_0_1"/>
    <dbReference type="InParanoid" id="E9GKM8"/>
    <dbReference type="OMA" id="SPIEQFM"/>
    <dbReference type="OrthoDB" id="751651at2759"/>
    <dbReference type="PhylomeDB" id="E9GKM8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140312">
        <property type="term" value="F:cargo adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="SSF49348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="SSF55711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Alpha_adaptinC2" evidence="10">
        <location>
            <begin position="711"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphatidylinositol 3,4,5-trisphosphate binding" evidence="8">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphatidylinositol 3,4,5-trisphosphate binding" evidence="8">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="622"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="634"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX80034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="943" mass="104844" checksum="7F56908AC42D7284" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKY1</accession>
    <name>E9GKY1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-Tim10_DDP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_52086</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX78122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX78122"/>
        <property type="gene ID" value="DAPPUDRAFT_246440"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_246440"/>
    <dbReference type="HOGENOM" id="CLU_2673608_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX78122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="75" mass="7787" checksum="698AD654BEABC255" modified="2011-04-05" version="1">MNPSTDGTTPDGDVERHVLGFKVGHLICAADFRGATSSLRAPTGTSNNRNNMSATKSLSSLHPSLSSCKLANPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9GRV7</accession>
    <name>E9GRV7_DAPPU</name>
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            <fullName evidence="1">HTH_Tnp_Tc3_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_105813</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732560">
        <property type="protein sequence ID" value="EFX77844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77844">
        <property type="protein sequence ID" value="EFX77844"/>
        <property type="gene ID" value="DAPPUDRAFT_105813"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_105813"/>
    <dbReference type="eggNOG" id="ENOG502SSFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9GRV7"/>
    <dbReference type="OMA" id="YHARDAN"/>
    <dbReference type="OrthoDB" id="1553369at2759"/>
    <dbReference type="PhylomeDB" id="E9GRV7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="109"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="330" mass="38635" checksum="81710AD5D8460F24" modified="2011-04-05" version="1">MGRFIGPLPEFHRETYRLSEAIKIEIVRLHRNEFGTPYRIAKHLKISKRSVNLWINRYEEERELQCKVNGNSRPSLTTENEDFLLTCSAVVNNFDNSLAIAGNAGLAHLSQDSISRRLTKSGMHSRVAAIKDILTEKHRAARLHFARRYVHYPIEFWRWVIFTDEKSWSSSAHGQLRVRRQKKTKIQSGKYLFHKKKRQNNSECLGRHVVGRNNSALPRYQQFNFRSIRDKRIRRNFASLVAPDWPTKGADMNPIENIWGYLVCKLTKARTEEGMPYHARDANNANLLFELVRTEWGKLINNEVYLQSLIESMPQRLQKVIDAEGGWTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9GS73</accession>
    <name>E9GS73_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_231122</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732561">
        <property type="protein sequence ID" value="EFX77659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77659"/>
    <dbReference type="EnsemblMetazoa" id="EFX77659">
        <property type="protein sequence ID" value="EFX77659"/>
        <property type="gene ID" value="DAPPUDRAFT_231122"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_231122"/>
    <dbReference type="eggNOG" id="KOG1700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026811_4_1_1"/>
    <dbReference type="InParanoid" id="E9GS73"/>
    <dbReference type="OMA" id="SHTFHHG"/>
    <dbReference type="OrthoDB" id="1214165at2759"/>
    <dbReference type="PhylomeDB" id="E9GS73"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="3">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX77659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="78" mass="8655" checksum="1FCE56B2A71F1133" modified="2011-04-05" version="1">MPNCPKCQKPVYFAERKTSLGKDWHGLCLKCEKCNKTLVPGQHAEHEGKPYCNNPCYSALFGPGGFGRGGAESYVYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GSN1</accession>
    <name>E9GSN1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_247541</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732562">
        <property type="protein sequence ID" value="EFX77458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77458">
        <property type="protein sequence ID" value="EFX77458"/>
        <property type="gene ID" value="DAPPUDRAFT_247541"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_247541"/>
    <dbReference type="HOGENOM" id="CLU_2280213_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241258" evidence="1">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="102" mass="10873" checksum="2C0F391AB56BBE47" modified="2011-04-05" version="1">MKSVGLIVSLSLLSLLVVVSKAWFLNLKSGKSDTEAKVTWSDEPDLQKSSWLCSVSFVLSKIRQNPFVAAAYAAPVQVPETVVAGQTWVMQYAGAGQAVAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9GSP5</accession>
    <name>E9GSP5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dimer_Tnp_hAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_247554</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732562">
        <property type="protein sequence ID" value="EFX77544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77544">
        <property type="protein sequence ID" value="EFX77544"/>
        <property type="gene ID" value="DAPPUDRAFT_247554"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_247554"/>
    <dbReference type="HOGENOM" id="CLU_009123_17_1_1"/>
    <dbReference type="InParanoid" id="E9GSP5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dimer_Tnp_hAT" evidence="2">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX77544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="86" mass="9249" checksum="6FCEF7F915D4FD83" modified="2011-04-05" version="1">MDDADADALPATSTEITNQSSSAPLKDLLNIPATSAASERAFTVGKDIFGISRMSLKPETVEALICLRSWYKAGLVGTEKIIKKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTI8</accession>
    <name>E9GTI8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_54466</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="EMBL" id="GL732564">
        <property type="protein sequence ID" value="EFX77090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77090">
        <property type="protein sequence ID" value="EFX77090"/>
        <property type="gene ID" value="DAPPUDRAFT_54466"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_54466"/>
    <dbReference type="eggNOG" id="KOG1221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024661_0_2_1"/>
    <dbReference type="InParanoid" id="E9GTI8"/>
    <dbReference type="OMA" id="SPIAGDC"/>
    <dbReference type="OrthoDB" id="815047at2759"/>
    <dbReference type="PhylomeDB" id="E9GTI8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:fatty-acyl-CoA reductase (alcohol-forming) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="PTHR11011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_4" evidence="6">
        <location>
            <begin position="18"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Sterile" evidence="5">
        <location>
            <begin position="359"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX77090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="464" mass="52593" checksum="04B67D3C9FF771A2" modified="2011-04-05" version="1">MASESIIADFFQDRSVFITGSTGFVGKVLVEKLLRSCPKIKRLYLLMRTSPNKDIATRRNELINNQVFSWIDQPNALDKIFAVAGDMTLPGLGISPADMQLLIEDVSIVINSAASVRFDDELKDALQTNVKGPRQLLAICQKMTKLEAFVHVSTAFNNLDRDVVGEMIYPSHIDPIKLINFLESIDGDFTRSITKQLLGKSNPNTYTFSKSLAEQILEREKHNVPLAIVRPSIVTAAAKEPTPGWIDSLYGPTGLIAGGAKGFLRLFKCEASCVIDLIPVDYAVNLIIAVAWHQATTKPSQLTVYTSSTSYHNPITIHQMRSFSEEAVTKYPPKEIMWCPSGECTNRDWYFRINIFLTHYLPAYLLDFTSQLFGKRAKMVKLYERVFRAISNLGFFNSHQWQFVSENSLTIQSKMSTADRKIFDFDVRQLNWRSYFETYIQGIRLFILKDDPSTLPQARKTLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E9GU06</accession>
    <name>E9GU06_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_306007</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Pangilinan J."/>
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                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX76337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX76337"/>
        <property type="gene ID" value="DAPPUDRAFT_107136"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_107136"/>
    <dbReference type="HOGENOM" id="CLU_1837119_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX76337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="140" mass="16311" checksum="74B431272771E984" modified="2011-04-05" version="1">MVRDRSEDVESVYIPEKLANRKRNRKSTIPIEVATFEWNGVRRMGEEDARLRFVAHWMSTVCHWGAGAGVPRRHHRHPHPWLRPCCYFVRVPLLVNFRMTYAAGGRVTQPASMDRMEGVIRRWPQAWASRPIVTASAVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9GXJ3</accession>
    <name>E9GXJ3_DAPPU</name>
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            <fullName evidence="7">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX75798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX75798"/>
        <property type="gene ID" value="DAPPUDRAFT_306653"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306653"/>
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    <dbReference type="InParanoid" id="E9GXJ3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
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        <location>
            <begin position="116"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="207" mass="23742" checksum="4CC3E3B908B2F7CD" modified="2011-04-05" version="1">MADFNDSQSQFFYQPAAAEEWIRQYQRIDRQLAELQLRLENGNDLDFIHKTVSGHLQELKCLYSSLLGSEHDDLGKRKMVIELIATATRLLSQIEQRKQFKDRLTPVFPNTGNQQMKIEEHKLLGMKQLHRSVESLNDVFKSLAQHVADQDSLVDSIESQIEWANENTNEGCQQLIEAKSSQNGKRWLIAKFTLVATFIVGVGLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="201" mass="22311" checksum="BFBFAB101C5A6F73" modified="2011-04-05" version="1">MFHLLFGTKAHLGAVAKSFSRLVMPRKPGIDLVLNVHLISSSILAFISLPRKRSSGIRRAIQAAVYEQNKNLRREANAQVRAAIEPQVAEPQVAEPQVAEPQVAEPQAAEPQVAEPQVAEPQAVQPRAIKQKSLEERIRQAVGIFNIIQDLHRRIPPQLLTLAQQAAGNFQFQNAIQPVSPREDEHVLQLAKLKSHSCFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX75637.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="98" mass="11039" checksum="00D897E219A816E4" modified="2011-04-05" version="1">MMKKQNVGCLVPYGMVSERREVSRKKGLMFAKNHSMIFFEASAKTKDGVQMAFEELVQKIIQTPGLWEVNAPSQRGMSLSYRTEGGQPWSCLGYCSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZE2</accession>
    <name>E9GZE2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_108181</name>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX75174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75174"/>
    <dbReference type="EnsemblMetazoa" id="EFX75174">
        <property type="protein sequence ID" value="EFX75174"/>
        <property type="gene ID" value="DAPPUDRAFT_108181"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_108181"/>
    <dbReference type="eggNOG" id="ENOG502QTQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9GZE2"/>
    <dbReference type="OMA" id="CAIRILV"/>
    <dbReference type="OrthoDB" id="1072875at2759"/>
    <dbReference type="PhylomeDB" id="E9GZE2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="506" mass="57305" checksum="239DA1B88B391F0D" modified="2011-04-05" version="1">MPRVNSRCKAVVSLRQQQRRIRATLERIYLVDEVVAEPNIAAESSSIQPEVNCSSSMNHLSDCEVYNVPGIEAVLTMDDGDSSEPVDEESDVDSYLSLYDSDSQNSCYGSDENLFKNIDWSSSESENGLEDEVKKKRLLSNSGPLGCGIEYSKELCVNVDGIPLYKSSRSQFWPILGLLRNIDGAKPFVIGIFEGTSKPLDVNLFLEDFVREVKFLETNGVILNGKVIPFKISAILCDAPARSFLTDVKGHTAYFGCPKCETKGKYAKNHNSKKGRVTFPTSNARLRNNHSFRTRRQAEHHKGRSLLEELNLDMVLNIPLDSMHLCDLGVMKKLMLAWAKGKFERVKLSKALFCLLDRLMCSVSNFMPTIFCRKLRGVVDLDRLKSTELRQFRLFLGPVILKTILPIQLYQHFLLFHYGTRILSDPELSGLPEMISYADKILKLFVHQSKTLYGKKFVSFNVHCLTHLAQEATTYGSIDTITCYPFENFLQILKTLLKRVQSHSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0S9</accession>
    <name>E9H0S9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_307197</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732582">
        <property type="protein sequence ID" value="EFX74651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74651">
        <property type="protein sequence ID" value="EFX74651"/>
        <property type="gene ID" value="DAPPUDRAFT_307197"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307197"/>
    <dbReference type="HOGENOM" id="CLU_960642_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="290" mass="30869" checksum="EB1A39240558C4D3" modified="2011-04-05" version="1">MARQHFAPQEFFTPQDIAPQDTKPQEVEPQVVDPNVVVPQENPNVTSQDAVPPQNVVPQEVAPQDVTPEVVTVVTPQDVTSQEAKPQDVTPQFVVPNVVVPQENPGTQDVAPHDVTTQNMPPQDVTVPPQDVTPQVVTPQNDVIGLSQDVTSQDVTAPQVVIPQDVTPQVVVPNVVVGLPQENPNVTPQGVTPPPNVTPEAVTPRVPGPQVPVPVPVPQVPVPQVPIPPVMHQVNSMAGCFWSGTSPFCAGHCGRFYKTIASDKSGDGKRCLTGTKKLCCPGTAALLRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9H1F1</accession>
    <name>E9H1F1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_251823</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732583">
        <property type="protein sequence ID" value="EFX74510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74510">
        <property type="protein sequence ID" value="EFX74510"/>
        <property type="gene ID" value="DAPPUDRAFT_251823"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_251823"/>
    <dbReference type="HOGENOM" id="CLU_193236_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX74510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="59" mass="6663" checksum="DADA3446C53C8A6D" modified="2011-04-05" version="1">MKLDIDTLATDDLDSIDSASLLSGSYFEFSFTPDFNDMLMYIGVSNDWVDKSFVNLIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9H1F3</accession>
    <name>E9H1F3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_108793</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Thomas W.K."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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                <person name="Thomas W.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
    <feature type="non-terminal residue" evidence="2">
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732614">
        <property type="protein sequence ID" value="EFX71069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71069">
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        <property type="gene ID" value="DAPPUDRAFT_309229"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309229"/>
    <dbReference type="HOGENOM" id="CLU_1827264_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="141" mass="14934" checksum="543965FF240B740F" modified="2011-04-05" version="1">MASSSGTGRETTKPALENEVGFLSPEANRLSDISSNNGEEAHATLQDISASPTVKRRPGRPRLRPVGPAHQGNRKSKSEGSAKKTRRGAPSGPRVIKPLPVPIGLMTTKNSEVTRTPMTPTSSTPIANSRPSSYLHDSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDS8</accession>
    <name>E9HDS8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_113009</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732625">
        <property type="protein sequence ID" value="EFX70119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70119">
        <property type="protein sequence ID" value="EFX70119"/>
        <property type="gene ID" value="DAPPUDRAFT_113009"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_113009"/>
    <dbReference type="HOGENOM" id="CLU_960610_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="290" mass="34057" checksum="850F189834AA704E" modified="2011-04-05" version="1">MECRSVYDLAKRKNNYGIFLWSIRYHRLDKHNGNYERRMQATRQQSHVRRKQNEVSKNSYEYRENPKEKGTWMQEITETKKNCATKKVILHRDCLTCPVMSPFGVLTNKTEVTTVITQDVTITWEDPILQKDEKCKLKKVISATGVKTKQDDGSFKMIDELNQLEFHYEERPNQQWMFEPDRSQMIGSREEIGPLLAQHHQYIEDKNLERENALLSEIKEIYCGNLQHRKYTTQLLAENNGIQAAIANNLPRCSRLKPNGVHLIVQQCKEMNVTVQGEKTKCGYEPRFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E9HEG4</accession>
    <name>E9HEG4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="13">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DAPPUDRAFT_300660</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 13">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="13"/>
    <dbReference type="EMBL" id="GL732629">
        <property type="protein sequence ID" value="EFX69841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69841"/>
    <dbReference type="EnsemblMetazoa" id="EFX69841">
        <property type="protein sequence ID" value="EFX69841"/>
        <property type="gene ID" value="DAPPUDRAFT_300660"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300660"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_3_1"/>
    <dbReference type="InParanoid" id="E9HEG4"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="OrthoDB" id="853728at2759"/>
    <dbReference type="PhylomeDB" id="E9HEG4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="PTHR11825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFX69841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="393" mass="44610" checksum="11488BACFB64B39C" modified="2011-04-05" version="1">MAVRGLILSVRLHPQKFLQNLRNVRCAATHQPFQYSDLEEKICTPDQLHPKPETSALVFGKYFTDHMLEVSWDSEKGWAKPVISPMHNLQLHPGAKVLHYAIELFEGMKAYRGEDGRLRLFRPDRNMARMLNTAKRSSLPTFDANEMIQCIKRLIQIDREWIPHSTTSSLYIRPTLIGTDPSLGVASPNQALLYVLLCPVGPYFTSGFKPISLLADPQYVRAWPGGCGAMKMGANYAPTIYIQKQSELLGHQQVLWLYGADHQLTEVGTMNIFVFMMNKAGERELVTPPLEGLILPGVTRLSLLELAREWKEFRVVERTITMAEMVEAHEEKRILEIFGAGTACVVCPISSISYQGRELNIPRSEASLSERFFKTMSDIHYGRLQHPWAVDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HET5</accession>
    <name>E9HET5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_258133</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732631">
        <property type="protein sequence ID" value="EFX69727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69727">
        <property type="protein sequence ID" value="EFX69727"/>
        <property type="gene ID" value="DAPPUDRAFT_258133"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_258133"/>
    <dbReference type="HOGENOM" id="CLU_2924911_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX69727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="61" mass="7146" checksum="FEF17714737F9E8F" modified="2011-04-05" version="1">MEKEITMLKEELKKVKTKKDEIEKALKKDQQIVAVIVLRALNQLTENEDLRNQLESAADYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9HFZ7</accession>
    <name>E9HFZ7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_329217</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732638">
        <property type="protein sequence ID" value="EFX69347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69347"/>
    <dbReference type="EnsemblMetazoa" id="EFX69347">
        <property type="protein sequence ID" value="EFX69347"/>
        <property type="gene ID" value="DAPPUDRAFT_329217"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_329217"/>
    <dbReference type="eggNOG" id="KOG2595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039465_4_1_1"/>
    <dbReference type="InParanoid" id="E9HFZ7"/>
    <dbReference type="OrthoDB" id="1107565at2759"/>
    <dbReference type="PhylomeDB" id="E9HFZ7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043547">
        <property type="term" value="P:positive regulation of GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GTPase-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GTPase_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="PTHR20913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="SSF47923"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX69347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="329" mass="38575" checksum="70EB92ECE9260F42" modified="2011-04-05" version="1">MFVYSVFLLRIKLLHQLKETGVSSEEIQHHQYYNQVVLDVKRILKCFPPGINENIQADLQVKVTELIIRVLIANEGLHYYQGFHDIAITLLLVLGEEKSYSVLCRLSQSHFQLFMGPDMEPTMEILNLVYALVKNENRDLYNYLIRSELGTIFCLPWAITWFGHVLNDYETVVRLFDVFMFSHPWISMYLSNVVVLHRASDIFLTPCKMPLLHQMLSNVPDNLPFDSLITETEKLMRTYPPDVMETVVREMHAENIRKIKEEDEERKRRMEQRKAALQGKHTKAAIERWTPWSGFRNLRSQTAKVVALSVSVATFSFIYNYVRPNIEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9HGK9</accession>
    <name>E9HGK9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_259121</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732642">
        <property type="protein sequence ID" value="EFX69134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69134"/>
    <dbReference type="EnsemblMetazoa" id="EFX69134">
        <property type="protein sequence ID" value="EFX69134"/>
        <property type="gene ID" value="DAPPUDRAFT_259121"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_259121"/>
    <dbReference type="eggNOG" id="KOG0161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_201378_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HGK9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX69134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="78" mass="9220" checksum="11A1E24BF172E088" modified="2011-04-05" version="1">MSTSRLQSEVDVLIFDFENANSTTREIQKRSKQLELINLEFKSKLDEIEQTVLYDASQRDNRNKATEIFRLTHELDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9HIT0</accession>
    <name>E9HIT0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_203299</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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        </citation>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Basu M.K."/>
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                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Dong Q."/>
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                <person name="Geiler-Samerotte K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Manak J.R."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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                <person name="Tsuchiya D."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732682">
        <property type="protein sequence ID" value="EFX67277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67277"/>
    <dbReference type="EnsemblMetazoa" id="EFX67277">
        <property type="protein sequence ID" value="EFX67277"/>
        <property type="gene ID" value="DAPPUDRAFT_229215"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_229215"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_471947_0_0_1"/>
    <dbReference type="InParanoid" id="E9HLV3"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="PhylomeDB" id="E9HLV3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
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        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
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            <end position="179"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
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            <end position="208"/>
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        <location>
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            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
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            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
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            <end position="327"/>
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    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="385"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX67277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="578" mass="66246" checksum="744F274DD6D83613" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9HM51</accession>
    <name>E9HM51_DAPPU</name>
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        <recommendedName>
            <fullName evidence="2">Tubulin-specific chaperone D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_262014</name>
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    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCD family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InParanoid" id="E9HM51"/>
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    <dbReference type="PhylomeDB" id="E9HM51"/>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0048487">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:bicellular tight junction assembly"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:microtubule cytoskeleton organization"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tubulin_specific_chaperoneD_C"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
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        <location>
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            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX67201.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="697" mass="79095" checksum="83F003194CB98B53" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HMQ8</accession>
    <name>E9HMQ8_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_262325</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732689">
        <property type="protein sequence ID" value="EFX66969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66969">
        <property type="protein sequence ID" value="EFX66969"/>
        <property type="gene ID" value="DAPPUDRAFT_262325"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_262325"/>
    <dbReference type="HOGENOM" id="CLU_3052434_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX66969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="54" mass="6147" checksum="DA55EA7FFA0E6A12" modified="2011-04-05" version="1">MDPRSDSVRVLRTEFLHCVNYLWSLVSSQSASNQLRQIARLTTQHSAEDKGSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9HMW1</accession>
    <name>E9HMW1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_331590</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732690">
        <property type="protein sequence ID" value="EFX66932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66932"/>
    <dbReference type="EnsemblMetazoa" id="EFX66932">
        <property type="protein sequence ID" value="EFX66932"/>
        <property type="gene ID" value="DAPPUDRAFT_331590"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_331590"/>
    <dbReference type="eggNOG" id="KOG1987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004253_9_3_1"/>
    <dbReference type="InParanoid" id="E9HMW1"/>
    <dbReference type="OrthoDB" id="864323at2759"/>
    <dbReference type="PhylomeDB" id="E9HMW1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="SSF54695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX66932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="137" mass="16230" checksum="73A2DFD4DF4FE40F" modified="2011-04-05" version="1">MFQHQTEDYLSEPVEIEDVEPLVFREILHFISTGRLSESEMKSTMPFEILKVAAKYLLDQLKMECETQLIHRISADNCMQLLFFTEENHSAFYLKKHAIQFFRNFSSEVIATEAWEKVERDHPKLCLTTLKKIVETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9HP74</accession>
    <name>E9HP74_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_17668</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732703">
        <property type="protein sequence ID" value="EFX66461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66461"/>
    <dbReference type="EnsemblMetazoa" id="EFX66461">
        <property type="protein sequence ID" value="EFX66461"/>
        <property type="gene ID" value="DAPPUDRAFT_17668"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_17668"/>
    <dbReference type="eggNOG" id="KOG0019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2564925_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HP74"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX66461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="82" mass="9345" checksum="C06E6F9EA7E11BFC" modified="2011-04-05" version="1" fragment="single">FLPQETDKIVEMVVIFKSPCCIVTSQYGWTANMERIMKAQALRDTSTMDYMAAKKHLEINSDHPIVEALRVKAETDKNDKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPB6</accession>
    <name>E9HPB6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_26145</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="EMBL" id="GL732704">
        <property type="protein sequence ID" value="EFX66416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66416"/>
    <dbReference type="MEROPS" id="M12.A38"/>
    <dbReference type="EnsemblMetazoa" id="EFX66416">
        <property type="protein sequence ID" value="EFX66416"/>
        <property type="gene ID" value="DAPPUDRAFT_26145"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_26145"/>
    <dbReference type="eggNOG" id="KOG3714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017286_4_0_1"/>
    <dbReference type="InParanoid" id="E9HPB6"/>
    <dbReference type="OMA" id="TAIRCSW"/>
    <dbReference type="OrthoDB" id="681837at2759"/>
    <dbReference type="PhylomeDB" id="E9HPB6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="5"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX66416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="206" mass="23004" checksum="1F27FEEFAA8BF59E" modified="2011-04-05" version="1" fragment="single">RELRNAIIGVNFRWPDAVIPYVITSSYTPSDRSVIARAMMEYHNKTCIRFVPRTIQPDYIIIKTTGSGCNSNIGRTGGSQVVSLDQGCVHVSLIIHELMHAAGFFHEQSRTDRDDYVVINYGNIQDGMQNNFNKLGPDMIEFLGTSYDTGSVMHYDQFAFAKDRNVPTIYSKTGGTLGNTQGFSQNDVLKLNLMYQCSPVVETTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPL4</accession>
    <name>E9HPL4_DAPPU</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_229447</name>
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    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX66283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX66283"/>
        <property type="gene ID" value="DAPPUDRAFT_229447"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S88E">
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    <dbReference type="HOGENOM" id="CLU_065450_3_0_1"/>
    <dbReference type="InParanoid" id="E9HPL4"/>
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    <dbReference type="PhylomeDB" id="E9HPL4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013243357" evidence="3">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX66283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="126" mass="13252" checksum="FE29A4F185B56371" modified="2011-04-05" version="1">MKFIVALAFLAVALAAPQGDQKPIEIISSNSEMNADGSYSFDFESADGTKVSESGNQKQVGPKPEDIGTVSKGSYSFTTPDGVVLTVNWVADENGFQATGDHLPTPPPMPEHVVKMLADLKAAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9HSC9</accession>
    <name>E9HSC9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_117344</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX65346"/>
    <dbReference type="EnsemblMetazoa" id="EFX65346">
        <property type="protein sequence ID" value="EFX65346"/>
        <property type="gene ID" value="DAPPUDRAFT_117344"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_117344"/>
    <dbReference type="eggNOG" id="KOG0330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_1"/>
    <dbReference type="InParanoid" id="E9HSC9"/>
    <dbReference type="OMA" id="CSKGWKH"/>
    <dbReference type="OrthoDB" id="1223767at2759"/>
    <dbReference type="PhylomeDB" id="E9HSC9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="113"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="334"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX65346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="504" mass="56352" checksum="9A30D7A9AAF6755A" modified="2011-04-05" version="1">MVKDLNERQEQDKLNKSYKGNPKVCIVSCKDANLNHYSGQSYGKFDKVPLTSRSWGHRKTNGDHFVINSQGPNPSILRDEESDFSKLLISELLTENLTKMGCTKPTIVQKLAIKSVYRGENTLIAAETGSGKTLSYLAPVIQKILDYKMSKNIVEGSSATPLNAPLGLVITPGRELCEQISKVCQSLIENLPIKAQCVTGGRLKRDMLNAEFAEVDILFSTIGAISKLTTNHIVRLDQLKHLVLDEADTLLDDSFNEKVSHFLRKCPLQMTRPTEGVYQGVQVVMASATIPRSAEEILSQVIPFSSFNKVTTQQLHRLLPHVPQKFVRISHLDKPARLLELVKKDVSRNLPVIVFSNRSDRCDWVSMFLNENGVSCVNLNGNMAQHFRVGRFEEFLTGKQMVLSCTDVVSRGLDTTNAHHVVNYDVPNNISDYIHRCGRVGRVGHPSTGIVTTFVCHPTEAELVQKIEYAARKTHEDELPNVNANIKRLINSQVLKKNEKSLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HTQ3</accession>
    <name>E9HTQ3_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DAPPUDRAFT_333743</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732782">
        <property type="protein sequence ID" value="EFX64871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64871">
        <property type="protein sequence ID" value="EFX64871"/>
        <property type="gene ID" value="DAPPUDRAFT_333743"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_333743"/>
    <dbReference type="HOGENOM" id="CLU_1688526_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HTQ3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX64871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="156" mass="17749" checksum="618F92B2066017E2" modified="2011-04-05" version="1">MDKYNERRRNSRKKEIPFSGTRGFGACSSSALASKSGPELEKGRGKQRKRPLKSSSGGTIESQEDTSRKGYVNDRVNSCSSFQEYMEHVNQTSALHNLFENSVIDEKDDTRMPKKSWKERVEATECAWKEAFQTLLEDHMLFDVAVAICFIVENVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HUM1</accession>
    <name>E9HUM1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_334082</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732814">
        <property type="protein sequence ID" value="EFX64559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64559">
        <property type="protein sequence ID" value="EFX64559"/>
        <property type="gene ID" value="DAPPUDRAFT_334082"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_334082"/>
    <dbReference type="eggNOG" id="ENOG502T8YR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060623_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HUM1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX64559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="246" mass="27792" checksum="B748B493821886B0" modified="2011-04-05" version="1">MARNKKRDARYSKSRAVKESAKNAAKASALKRRQQKEERERLAGDQEPVIDFDTVPEAQDREEEAVAVEEPVEEPVEEPVEEPDEEPGQELVASQRPELDQDPEIEDESSVSEDDEQKAGTEEEEPVVEPLTPKVVTVQLERLDLSPATLQRLKRVQKAKKRKEREDSSKSGSSPPKRTRSQTRRPIKEGSSSETADPDGEVHLHYISHLNVIMLLTKNLFMVLDIPNFIVPVLKTFVRLVLKGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HUX7</accession>
    <name>E9HUX7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_118163</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732827">
        <property type="protein sequence ID" value="EFX64455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64455">
        <property type="protein sequence ID" value="EFX64455"/>
        <property type="gene ID" value="DAPPUDRAFT_118163"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_118163"/>
    <dbReference type="HOGENOM" id="CLU_2280207_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HUX7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX64455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="102" mass="11879" checksum="065F3860F78E598F" modified="2011-04-05" version="1">MATRFPLEMIEEEPEEEELEEDEPEEWQTTADPAVIKHRRISAKSAHTKSLNEALLATRAGEDVEKVKLLRAIMVREYEALKEIHTRYMELAKLNQEDGDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HVS8</accession>
    <name>E9HVS8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_334530</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
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        <source>
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</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="367" mass="41189" checksum="DF0B5288355B7015" modified="2011-04-05" version="1">MCVPISNKEKPLVSVLSQNKTCVPISPEKNESIEYEAISSYAFKNGSEKRSLDVSKNYKAKKHCGDISISDLFRDQRMKSDLEETLLESPNIVIQPKIRKHSQSFVSLGTTRVPSVDKQNPLTNSPVERMGTSSNQCVYTAEELEQLDLAGLPEPKTKEQLDEIMRLFHAAVHERDVVCCVCDQFLRISESTLVPSTSLPTAFFEKLQQPTGKNGDANVLHPQLVRQYDVSDSFPSERNRFAKFLLSPRGIEKHRSSCTPDGISDCDCKPFLRICKKKCYDCLKRNALPKLAVANGNWFGQLPEQLRNMTLGTRSLVRPVHNSGHLVAYSSKTYVGGTSITGHIYSNRLDTPLVRMSLPLQPSPFKR</sequence>
</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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                <person name="Shaw J.R."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <begin position="175"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="238" mass="27751" checksum="7F25109DF220A7F0" modified="2011-04-05" version="1">MKLSELPVIQASLEEEARVAREKEKIVKLKWDYLSELKSELERIHFQHVTLHDRISSVAAKAVTVMNDINDLANVMVTEQNFLDGVFPWDSNQNVSFKDNFKLVDCWMLYKRNTEQILQCKLEMSQFITTISEDILSMQHEIRNYNSTDEFSFSVSNCPMNISVFQQSEIVIKMQEVKRLEMLLSDSLALKQYFYEENLDDDDLVFEDDCTDDYIADGDGIDKDDLCDEIECSSDDEF</sequence>
</entry>
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    <accession>E9HX69</accession>
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    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
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    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Geiler-Samerotte K.A."/>
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    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_335858"/>
    <dbReference type="eggNOG" id="KOG0306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_923081_0_0_1"/>
    <dbReference type="InParanoid" id="E9HYL3"/>
    <dbReference type="OrthoDB" id="960224at2759"/>
    <dbReference type="PhylomeDB" id="E9HYL3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX63167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="302" mass="32849" checksum="A2B1C632E4848D00" modified="2011-04-05" version="1" fragment="single">QSPESTEELTVALQDEVLRIKSVQASGKVKAIDVHVSTKGELGLLALLRGNSFEIHVVDTKVSNKNDATKVGALSIPGHRTDVRALCFSLDKIALASASGESLKIWNRGSQNCIRTMACDYALSILFATGDHNVIVATKTGKLQIFDIAAGRLLEEIRAHEGEAWTVAMSPDLRGIASGGADKSVKFWQFEFVVDKAAATSQTRVLQFQGEFGRLRVEFMSACSQLVQACRTLQTAPPSAIADAVAAATRDELQRCGRITHQLRKSVLVLRQVAEACPSWDRAPSTPTRRASRICSYKSRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9HYY8</accession>
    <name>E9HYY8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_336024</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733247">
        <property type="protein sequence ID" value="EFX63042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX63042"/>
    <dbReference type="EnsemblMetazoa" id="EFX63042">
        <property type="protein sequence ID" value="EFX63042"/>
        <property type="gene ID" value="DAPPUDRAFT_336024"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_336024"/>
    <dbReference type="eggNOG" id="KOG0701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_957308_0_0_1"/>
    <dbReference type="InParanoid" id="E9HYY8"/>
    <dbReference type="OrthoDB" id="935825at2759"/>
    <dbReference type="PhylomeDB" id="E9HYY8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090501">
        <property type="term" value="P:RNA phosphodiester bond hydrolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="100"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="270" mass="29877" checksum="76424094C4FFCD4E" modified="2011-04-05" version="1" fragment="single">MAEAKVVQVLVEISHDKLMEFMDFVDRINGDVKKVDMHAEPVPGSLPETAAENESVDLAEGLPIKIMKKAVKCLGEALASPVPPKSKKSKPLTCNQLSAVKAFEEILNYSFNDKEVLLEALTYGNSIRSLNYQRLEVIGDAAFGFLAALNFFKQSLYHSAGDISQLRSACVCNDTFGMLAAKRNFHAYIQNLPPNLVKHLEDFLEFAESENFAPFDRELAENEEIIATQVAIPTFLADVFEAVAGAVITDSNLSFETLEKVFVPFMNSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9I014</accession>
    <name>E9I014_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_67813</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL733454">
        <property type="protein sequence ID" value="EFX62664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX62664"/>
    <dbReference type="EnsemblMetazoa" id="EFX62664">
        <property type="protein sequence ID" value="EFX62664"/>
        <property type="gene ID" value="DAPPUDRAFT_67813"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_67813"/>
    <dbReference type="eggNOG" id="KOG0019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_2_2_1"/>
    <dbReference type="InParanoid" id="E9I014"/>
    <dbReference type="OMA" id="PHARDIT"/>
    <dbReference type="PhylomeDB" id="E9I014"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX62664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="202" mass="23917" checksum="D4C0B67B46096CD5" modified="2011-04-05" version="1" fragment="single">EFYKSLTNDWEDHLAVKHFSIEGQPEFRALLFVPRRAPFVLFENHKHGNHIKLYVCRVLIMDNCEELIPEYLNFMKGVVDSEDLPFNISREMLQQNKMLKVIRKNLVKKCMELFEELAEDKENFKKFYEQFSKKLKLGVHEDSINRKKIADLIRFPTSSSGEDQVSFKEYVSRMKENHGRQEALGNQLRPSHRRSPARQSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9I106</accession>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX62325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62325">
        <property type="protein sequence ID" value="EFX62325"/>
        <property type="gene ID" value="DAPPUDRAFT_337110"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1691127_0_0_1"/>
    <dbReference type="OrthoDB" id="1807750at2759"/>
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            <begin position="56"/>
            <end position="132"/>
        </location>
    </feature>
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            <begin position="56"/>
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        </location>
    </feature>
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            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
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            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX62325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="156" mass="17659" checksum="0BE3298047550683" modified="2011-04-05" version="1" fragment="single">MQSYRYLPVYQMKVLRALNVGVSETQQMDEIQTLKNFLNYWEKIFFLMEGKRKLNEPAEVEQCHRTETKFSTVHDDAESESSDNSENNSADSSEDEYDAVSEDENADENVVVSHSLPTGSGDTTDDAEADVRDHNMTIDFSYSVGADGELVLTKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9I539</accession>
    <name>E9I539_DAPPU</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">DAPPUDRAFT_275077</name>
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        <name type="scientific">Daphnia pulex</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX60891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60891">
        <property type="protein sequence ID" value="EFX60891"/>
        <property type="gene ID" value="DAPPUDRAFT_275077"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_275077"/>
    <dbReference type="HOGENOM" id="CLU_895064_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
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            <begin position="210"/>
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        </location>
    </feature>
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            <begin position="28"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="124"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX60891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="311" mass="35165" checksum="01F27962117F156F" modified="2011-04-05" version="1">MSGQQSRSSKRIQGIAASPPRPLVTRRTTSQSEREETEHTAPRTEQGENLEKIPAETSTRQKCKFTSQAGKRHPPGDQEATGSRTQHDPEQHRNTTPRPAVTKEETVVSQTRAKQTVRRRSRQRPTRRPEEDRHTKKMRGINLLLGNDVLRRFKKLQIEYGTGKPKMRFGDLPVQMAIEDPTPSPRNKIIAKTGITIPARSMVAMEIEQSEATRPTEDGRPWMLEPTKRRGPTPGRALMPGDRPATWILVTNLEHRPVYVHKKTVLGFRTDVTGEGTDLHSTNEGATAEEQERPWRSLIPIDNIANHVTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9I6C4</accession>
    <name>E9I6C4_DAPPU</name>
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        <name type="common">Water flea</name>
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        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL736362">
        <property type="protein sequence ID" value="EFX60456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60456">
        <property type="protein sequence ID" value="EFX60456"/>
        <property type="gene ID" value="DAPPUDRAFT_343678"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_343678"/>
    <dbReference type="HOGENOM" id="CLU_530258_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9I6C4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="53" mass="6612" checksum="F937E481EA63A537" modified="2011-04-05" version="1" fragment="single">MVKKTFPYSTTKDVLMTWEEMNKSFLLTKIPETTQIQLEKMRKRRYEEREKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9I7N1</accession>
    <name>E9I7N1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_279950</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="256" mass="28242" checksum="ED585F6C893EA3BE" modified="2011-04-05" version="1">MESHVEVYNCETYTGKASIAKVMYESFKPSEINSHGSVPGFFVMGFMQMRNYFYQYPPTGACSMKAVLHRTQVNPAEAVEIKLKMDSAVPSGKKAAPGKTFSNVKGAVTLLGSPERKWNVEVNIEKEPFNVRSQVAVKIARLANPGLKVPSRALCVNVKTAWANLPEDIFETPSTIEPSVQREVSFVWGEAPSDQCPKANAKDISTITVKVQGSKKLCSADQIANPAFVLLYLGVLHILYRDCYRNCTPSCELLVQ</sequence>
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            <fullName evidence="2">Focal_AT domain-containing protein</fullName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DAPPUDRAFT_39328"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="199" mass="22033" checksum="B426B5A9782A5CF6" modified="2011-04-05" version="1">MDGANACQKDRSTPLQGNQLDDRSVVVKKLEPTPTARLDRTHDKVYDATTSVVRAVMLLSQGVQQAKIENYVDLVKKVGLELRTLLTSVDQLVPHFPPSTHREVEMAHKVLSKDMAELVSALKLAERYSNTTLDNEYRKGMLSAAHILAMNAKNLLDVVDHVRIKHPHVNVYFSSSNRSQDSSAGCSTADNTSYQISSS</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Kriventseva E.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DAPPUDRAFT_232232"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1121062_0_0_1"/>
    <dbReference type="InParanoid" id="E9FS61"/>
    <dbReference type="OrthoDB" id="1258047at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49842"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5003240494" evidence="2">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="3">
        <location>
            <begin position="182"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX90373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="248" mass="26188" checksum="FF47737799A0C89E" modified="2011-04-05" version="1">MFHFSLFVLALVALTSCQADQQIKPNSATVARRASAPTIRPSIKVDKIRDVEAVDPGLLSPPSATKNSTGTRSVTDTLGKQSNTGSSSQGTLLGQETIFGNPIFKNAFGGGNNFNQQDNGFQQFSPGQPVGGFGQQGQVGGFGQTPGTFNQPGIGGFPNNNGGVFPGGGVLPGGSQLPPGSVAADSVAFSAARASDFTRVGVTQVRFDYTLTDIGYGWYPDRSEFVCYYPGLYYFTYHGLSTQTRQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSJ8</accession>
    <name>E9FSJ8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_303105</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89818"/>
    <dbReference type="EnsemblMetazoa" id="EFX89818">
        <property type="protein sequence ID" value="EFX89818"/>
        <property type="gene ID" value="DAPPUDRAFT_303105"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303105"/>
    <dbReference type="eggNOG" id="ENOG502RZS2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1257195_0_0_1"/>
    <dbReference type="InParanoid" id="E9FSJ8"/>
    <dbReference type="OMA" id="REEYNTK"/>
    <dbReference type="OrthoDB" id="1339114at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240287" evidence="3">
        <location>
            <begin position="23"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX89818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="220" mass="23524" checksum="63AD354CE5ADEC7D" modified="2011-04-05" version="1">MAMKHMMLVVAVLLVAAAYANGQQSTTPVPILKQINRVNDDGSYTYGFEAADGTFKVETRDNLGNVRGKYGYVDETGQLKTVEYAAGQGFEASGAHLPVDGNSAAPLPAAQPITAAHPRRPVARPVPAPTTFRPRPAVVQQPAAPVHHVAPARNLPTPTLSVPSFSNVRQQQPQQAVPQHFDNAIVSNTGNAGRGFSFSFEAPVFHPTTTTPQPFFNQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E9FTM2</accession>
    <name>E9FTM2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_40755</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89613"/>
    <dbReference type="EnsemblMetazoa" id="EFX89613">
        <property type="protein sequence ID" value="EFX89613"/>
        <property type="gene ID" value="DAPPUDRAFT_40755"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_40755"/>
    <dbReference type="eggNOG" id="KOG1733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141397_0_2_1"/>
    <dbReference type="InParanoid" id="E9FTM2"/>
    <dbReference type="OMA" id="MAAWNQV"/>
    <dbReference type="OrthoDB" id="1566384at2759"/>
    <dbReference type="PhylomeDB" id="E9FTM2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space protein transporter complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039238">
        <property type="entry name" value="Tim8/13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19338">
        <property type="entry name" value="PTHR19338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="SSF144122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="zf-Tim10_DDP" evidence="4">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX89613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="90" mass="10151" checksum="E9983A6D8D3DDB7D" modified="2011-04-05" version="1">MDSPPSTGRLTGAQREELIEQVKQQVAIATAQELLTKISEKCFKKCIAKPSSSLDSSEQKCIAMCMDRYMDSWNLVSKAYSSRIQKESMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUN1</accession>
    <name>E9FUN1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_311102</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <begin position="303"/>
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        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="457"/>
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        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX88673.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="674" mass="76345" checksum="FBBDE628397FB49C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9FW99</accession>
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        <submittedName>
            <fullName evidence="4">Putative Kruppel-like factor 6</fullName>
        </submittedName>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX88687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="429" mass="47762" checksum="7A9243CCFD0450F5" modified="2011-04-05" version="1">MDILPSGNIFRELQVVHDTGYLSAQTSLEDHWEQTCYEMERYLKDEPQQQQPSSSPLCSSSAAAALRRAESFDMLSSSIQPASYLAPDSVNSPMWPWSFKQEPVDPDTDPDDGCQLLRAHKHHHQIALRLGLKLRAGETYADESTEADESDRELEEEEEEEEEEEEEEMERRKGGRALDAVSLSSASSRSSRGSWDSLGDLDPTLRIHPYSSSCSSSHTSTNNNSHHHHRPNHRGPVRIYHHHHKTPRGGGQLLTPPSSPESIRASMVSALKSATAANRNANGKVSVNNNNVTAASNVADNVAAAELSGTQTSRNAAAAAAVRTLTALGLTPATSRGGVAERRRIHKCQFPGCKKVYTKSSHLKAHQRTHTGEKPYQCSWEGCQWRFARSDELTRHYRKHTGAKPFKCVHCERSFSRSDHLALHLKRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
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        <name type="common">Water flea</name>
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        </lineage>
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    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Liu Z."/>
                <person name="Jiao Y."/>
                <person name="Yu P."/>
                <person name="Cai M."/>
                <person name="Zhao Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Mu family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="QNM80584.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88365"/>
    <dbReference type="EnsemblMetazoa" id="EFX88365">
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        <property type="gene ID" value="DAPPUDRAFT_230303"/>
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    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230303"/>
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    <dbReference type="OrthoDB" id="1162336at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003081">
        <property type="entry name" value="GST_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01267">
        <property type="entry name" value="GSTRNSFRASEM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="90"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX88365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QNM80584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="218" mass="25086" checksum="BA095EAEEC8F5952" modified="2011-04-05" version="1">MAVKTGYWNIRGYMQPIRLLLAHAGVEYEDKRYNVGPAPDYDRSEWLNDKFNLGLDFPNCPYYIDGDVKISQTFAILKYLGRKHNLAAKTEEEQIRVDLMEAEAIDMRTKWSTLCYNADFENMKPDYIKNAPVKLKEVSTFLGSHPYFAGQNITYIDFVIYELLDQNSQLIPGLLDEFPNLKEFHARIGGLEKVAAYLSSDKCIKYPFNGPMAQWGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXH1</accession>
    <name>E9FXH1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_42388</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88078"/>
    <dbReference type="EnsemblMetazoa" id="EFX88078">
        <property type="protein sequence ID" value="EFX88078"/>
        <property type="gene ID" value="DAPPUDRAFT_42388"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_42388"/>
    <dbReference type="eggNOG" id="KOG4419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_7_1_1"/>
    <dbReference type="InParanoid" id="E9FXH1"/>
    <dbReference type="OMA" id="RMAVIQY"/>
    <dbReference type="OrthoDB" id="484599at2759"/>
    <dbReference type="PhylomeDB" id="E9FXH1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="38"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="3">
        <location>
            <begin position="348"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX88078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="615" mass="66954" checksum="D92AD131C8D76283" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXV7</accession>
    <name>E9FXV7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_96431</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88225">
        <property type="protein sequence ID" value="EFX88225"/>
        <property type="gene ID" value="DAPPUDRAFT_96431"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_96431"/>
    <dbReference type="HOGENOM" id="CLU_960632_0_0_1"/>
    <dbReference type="OrthoDB" id="1909852at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="290" mass="30256" checksum="C3D70898D318C715" modified="2011-04-05" version="1">MATLHSSSTGVVGASGAAGGRTSVVRAPISASLPSLFARTLPTQSNRQRQSSQQQPASRTTPTTTDLHRGRLVSTECQTEMEDSVQQNVRVENARNETSTVGGGGAVVVLLDPSGRTRSRPVSQLSESGLSGVEEAVTELERGPPRRRRREKRRHRRSSQVPAQPLQQHVQQALHDQTELSVDSLSAAPVSPSNSDHLPDILNAHMPPPYSTLPHNSERCMGMGPIPITALPVPLSVVPMAIGPTAAGGGLLVPPSTTTTPAVVGVPAGGGSTSLLASNSFTLPPAGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZI1</accession>
    <name>E9FZI1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_312570</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exonuclease superfamily. TREX family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87264"/>
    <dbReference type="EnsemblMetazoa" id="EFX87264">
        <property type="protein sequence ID" value="EFX87264"/>
        <property type="gene ID" value="DAPPUDRAFT_312570"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312570"/>
    <dbReference type="eggNOG" id="KOG4793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067419_1_0_1"/>
    <dbReference type="InParanoid" id="E9FZI1"/>
    <dbReference type="OMA" id="VDTMVAI"/>
    <dbReference type="OrthoDB" id="1365966at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000738">
        <property type="term" value="P:DNA catabolic process, exonucleolytic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="PTHR13058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240723" description="Exonuclease domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="4">
        <location>
            <begin position="44"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX87264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="252" mass="27996" checksum="6CCF6793A755DC6A" modified="2011-04-05" version="1">MAASSSTMPVMISSVGIAVASASVVHLVPPVSTLRLVTPATFNSYVFLDLETTGFITTEDPICRITELSMWGIEREQFLNCNGSKMPRITNRLNMCVDPSKEIHPMAATKSKLDNLNLSHQSPFDEDVANTVLSFLNRLKKPMCMIAHYGFKFDFPVLKSEIANVGKDFSEDVFCADSLPVFRTCQSLAQGVPYSYTLENVYRRIYNNQPEVMHEAEADVKMLFWAAAATPRPFLNAVANIAVPIATITKCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZV6</accession>
    <name>E9FZV6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_97391</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87194"/>
    <dbReference type="EnsemblMetazoa" id="EFX87194">
        <property type="protein sequence ID" value="EFX87194"/>
        <property type="gene ID" value="DAPPUDRAFT_97391"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_97391"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_4_0_1"/>
    <dbReference type="InParanoid" id="E9FZV6"/>
    <dbReference type="OrthoDB" id="1918155at2759"/>
    <dbReference type="PhylomeDB" id="E9FZV6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003239907" description="Peptidase S1 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="87"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX87194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="333" mass="36820" checksum="3C41FF474A7DE84E" modified="2011-04-05" version="1">MKSLLVVCLLALVVMVSTAPQVPIPFYPFPGITISNDNSKSKPIAPTVPVTGVIHAESKPKEWLSSTPTVADRSRCLADYRSKNPDVPPPSSVEIASPHQYPFVVSILYFSEDKGYSYECSGSLISPTKVLTESHCLYYNPTYGITLPVERLKVRLGKHFLNGTTSDAQVTRNVTKIETHRGSSELAIVTMDSPVEYTDTISPVCLVPDCFDDDSGQSVIAMGWNYPPHPHEIETIHPISLGFMRLSTLPIGKCYDEDVKELFQTEALCAQKTCGDLCPTYRGGPVVIENKSQDDKSCRFMQVAVLNSYYGHSDVGSLSRVKNFLPWFEENSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9G0R4</accession>
    <name>E9G0R4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_97135</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87357">
        <property type="protein sequence ID" value="EFX87357"/>
        <property type="gene ID" value="DAPPUDRAFT_97135"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_97135"/>
    <dbReference type="HOGENOM" id="CLU_702600_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX87357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="393" mass="41710" checksum="391298E11FA02E59" modified="2011-04-05" version="1">MSQNGDDAEARDAMINPVQRRESSAARFLKHFRPDRNNPAYHSEGKGLRKRRNWASERQLTTNSDHPAPSGNDPATPAAAAASAVAQRPAANSNAPQRSHSFSEPDASGGPAGGASRTPFKENSGMRESFRWRFGSSKSSSSSSKSSSISSDHPPKGGDTGKSPAGNNSGAPPPLTRTKSEGLPSSGGKDNPSTTTTTAVSTSQQQPPPCTNLNNPPAAGNNWSQLHHLPGGHFNNKSPSKKCIHDSTTTVVDGRSSGVHIQQQQEHQAGSTSPSEPIYSNGQAQTTVGSSSSSSRVVNYYASTSSSSGGADADYVNYEMFASHQYSWSNHQKQLEPDLIRNLPYQQQQQQQSGSTVAAPVNGHSPAKQPGNAPFITANPSPHHRHSNRVHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1K9</accession>
    <name>E9G1K9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_44321</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86513"/>
    <dbReference type="EnsemblMetazoa" id="EFX86513">
        <property type="protein sequence ID" value="EFX86513"/>
        <property type="gene ID" value="DAPPUDRAFT_44321"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_44321"/>
    <dbReference type="eggNOG" id="KOG3933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2152005_0_0_1"/>
    <dbReference type="InParanoid" id="E9G1K9"/>
    <dbReference type="OMA" id="CKSWIST"/>
    <dbReference type="OrthoDB" id="1339087at2759"/>
    <dbReference type="PhylomeDB" id="E9G1K9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX86513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="112" mass="12733" checksum="545BD48A18DF5D43" modified="2011-04-05" version="1" fragment="single">AFDQDWHSVRPVARSFHPASVLLPLHQGWVVLGATPPSKFANAELMKIPNFFHLTPPTIERHCQAWKKFCTECCKSWISTKRLTPITITTSDYLNSFPSLSDAQARIVRLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3N4</accession>
    <name>E9G3N4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_98431</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85798">
        <property type="protein sequence ID" value="EFX85798"/>
        <property type="gene ID" value="DAPPUDRAFT_98431"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_98431"/>
    <dbReference type="HOGENOM" id="CLU_1005648_0_0_1"/>
    <dbReference type="InParanoid" id="E9G3N4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240592" evidence="1">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX85798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="277" mass="28296" checksum="C7C22754171B6974" modified="2011-04-05" version="1">MAAKFSVLLVVSMFVAVSMAGGKKGGSSYGDYSASYAPSYPSYPSYSEPSYAAPSYAAPSYAAPSYAVPSYPAPAYSSGKSSGGKKRRGGLKRLFKAIKGSDLDFEALFNTLASLSGDYSGGSSYAAPSYAAPSYAAPSYGGGKKGGKKGGNHYAAPAPYVAPVYSAPAYVAPVYSAPAYVAPVYSAPAYHAPTYAAPAYHAPAYAPSYGGGKKGGKKGGSQYSVSYAPTYVPSYQAPSYPAPSYHAPSYPAPSYSAPSYSAPAYEVSSYSAPAPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9G443</accession>
    <name>E9G443_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TNF_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_309029</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85685"/>
    <dbReference type="EnsemblMetazoa" id="EFX85685">
        <property type="protein sequence ID" value="EFX85685"/>
        <property type="gene ID" value="DAPPUDRAFT_309029"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309029"/>
    <dbReference type="eggNOG" id="ENOG502QUAV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1817747_0_0_1"/>
    <dbReference type="InParanoid" id="E9G443"/>
    <dbReference type="OMA" id="FINTEPF"/>
    <dbReference type="OrthoDB" id="1604425at2759"/>
    <dbReference type="PhylomeDB" id="E9G443"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021184">
        <property type="entry name" value="TNF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00207">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="SSF49842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00251">
        <property type="entry name" value="TNF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="TNF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNF_2" evidence="3">
        <location>
            <begin position="18"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX85685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="142" mass="16014" checksum="E1281E3CCA60F42F" modified="2011-04-05" version="1">MESVVEIASRNELGLHTSWKIAPSNWDSPLKTTPLVKIDGAILTVKQSGLYFIYAQVHYLDEHSTNAYEVFINTEPFLRCITSAFSETSFPKANTCYTAAATQLREGDKLFLRDIEPLRYSVLQPSKTFFGLIRMAPIADFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9G600</accession>
    <name>E9G600_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_9558</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX84852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84852">
        <property type="protein sequence ID" value="EFX84852"/>
        <property type="gene ID" value="DAPPUDRAFT_9558"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_9558"/>
    <dbReference type="HOGENOM" id="CLU_010412_6_6_1"/>
    <dbReference type="InParanoid" id="E9G600"/>
    <dbReference type="OrthoDB" id="1536766at2759"/>
    <dbReference type="PhylomeDB" id="E9G600"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="51" mass="5741" checksum="B93BB00CCD3FBA18" modified="2011-04-05" version="1" fragment="single">MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6Z7</accession>
    <name>E9G6Z7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_238640</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84370">
        <property type="protein sequence ID" value="EFX84370"/>
        <property type="gene ID" value="DAPPUDRAFT_238640"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238640"/>
    <dbReference type="HOGENOM" id="CLU_1549181_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9G6Z7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009330">
        <property type="term" value="C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX84370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="173" mass="19394" checksum="9DCE90F0B6985B4C" modified="2011-04-05" version="1">MLKKIEDVEQELAFEVEASREKLINQNKFLAEISSKDLTVDSEKEGTTSSNYAPGSLITWEKKSNCDVDEANLSDQSPEDLWRRDLEKLLVILNEAEVAEQENLALIAETTPSAKGRRINPFTDVEKAIASPIVSSDDRNQAPTYVKIKVGSKPPSTLDMPIRYLPTEEKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9G766</accession>
    <name>E9G766_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_238705</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84697">
        <property type="protein sequence ID" value="EFX84697"/>
        <property type="gene ID" value="DAPPUDRAFT_238705"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238705"/>
    <dbReference type="HOGENOM" id="CLU_2388431_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="94" mass="9692" checksum="A3D4F46C18BA26C4" modified="2011-04-05" version="1">MSTTAAALIPSAAGNSSSASLFSGTHVATVSGGGHAVCETRVPCFYSVAPKKFVDSAEIGSHRQTTFLCVTQHNSEQPSTKSFAKGRSSTRSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E9G791</accession>
    <name>E9G791_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="5">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PAN2</name>
        <name evidence="8" type="ORF">DAPPUDRAFT_314726</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between nucleus and cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84426"/>
    <dbReference type="EnsemblMetazoa" id="EFX84426">
        <property type="protein sequence ID" value="EFX84426"/>
        <property type="gene ID" value="DAPPUDRAFT_314726"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_314726"/>
    <dbReference type="eggNOG" id="KOG1275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002369_0_0_1"/>
    <dbReference type="InParanoid" id="E9G791"/>
    <dbReference type="OMA" id="TQELLWT"/>
    <dbReference type="OrthoDB" id="128953at2759"/>
    <dbReference type="PhylomeDB" id="E9G791"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010606">
        <property type="term" value="P:positive regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="466"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="968"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="970"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="1092"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="1144"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX84426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1190" mass="132954" checksum="BFBC94B812BEDB18" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8H9</accession>
    <name>E9G8H9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_239159</name>
        <name evidence="2" type="ORF">DAPPUDRAFT_239162</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX83978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83978">
        <property type="protein sequence ID" value="EFX83978"/>
        <property type="gene ID" value="DAPPUDRAFT_239159"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84267">
        <property type="protein sequence ID" value="EFX84267"/>
        <property type="gene ID" value="DAPPUDRAFT_239162"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_239159"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_239162"/>
    <dbReference type="HOGENOM" id="CLU_1929669_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX83978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="116" mass="13249" checksum="19BEF01C389F399A" modified="2011-04-05" version="1">MSFECGGYQTVTPASYYTTTYATTGCYTTKVSEYYITTYDAPNFYSEASKYNYAQSYSTKAAEYYSTKAAEVQFHYTSTCAAPSYYTEAPKYYTKAAEYYTTYYASGSYYKGIPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAS5</accession>
    <name>E9GAS5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_240062</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX83309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX83309"/>
        <property type="gene ID" value="DAPPUDRAFT_240062"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_240062"/>
    <dbReference type="HOGENOM" id="CLU_128937_1_0_1"/>
    <dbReference type="OrthoDB" id="266752at2759"/>
    <dbReference type="PhylomeDB" id="E9GAS5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="EFX83309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="108" mass="12068" checksum="D2ED20F2FEF63BD4" modified="2011-04-05" version="1">MTTHAAPSCYTETPNCYTKAPADFSTKTVEYYTEAAKYFSAPIYTTTTEAAKYYAVPTRYTKVALSCYVEQQYYTDDPTTTCATPSYYNAAPKYYTEEAASDTTTYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9GB31</accession>
    <name>E9GB31_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_223447</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83439">
        <property type="protein sequence ID" value="EFX83439"/>
        <property type="gene ID" value="DAPPUDRAFT_223447"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_223447"/>
    <dbReference type="HOGENOM" id="CLU_1016557_0_0_1"/>
    <dbReference type="InParanoid" id="E9GB31"/>
    <dbReference type="OrthoDB" id="1340211at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026187">
        <property type="entry name" value="Aven"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16524">
        <property type="entry name" value="PTHR16524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="274" mass="31280" checksum="77911BC1BE0BC6AE" modified="2011-04-05" version="1">MGPKRKVKNDSKPDRKQESTDKLKAESATFASLTSGDTSSSEEALNSSKYSSRKLNSNWQKYDKDTDFVPEPRGLDFSDFSGKKPTTSTDSYFRFSNEKNWEVLEKFDDYFKLNVNDLCREIMCVPLQERLKLDSSVLTSEQIETFDNDAQMYESRMKEPLVLIKEITGKMLSLLSNEIEPKDKEKSCTTGWAHSKEEQSDKQQKTWDSNSENFFSLSGVEEELDLILAMPSIVSPSSPLEISPITEDLSEETSTVHSNLQLQNDWLDSLLDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBC4</accession>
    <name>E9GBC4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DAPPUDRAFT_302108</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="GL732538">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83182"/>
    <dbReference type="EnsemblMetazoa" id="EFX83182">
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        <property type="gene ID" value="DAPPUDRAFT_302108"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302108"/>
    <dbReference type="eggNOG" id="KOG0625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009330_0_1_1"/>
    <dbReference type="InParanoid" id="E9GBC4"/>
    <dbReference type="OMA" id="DIYKIYA"/>
    <dbReference type="OrthoDB" id="555015at2759"/>
    <dbReference type="PhylomeDB" id="E9GBC4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PTHR22573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="11">
        <location>
            <begin position="15"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="12">
        <location>
            <begin position="192"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="13">
        <location>
            <begin position="307"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="10">
        <location>
            <begin position="476"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFX83182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="561" mass="61007" checksum="887D965D3F52C0E1" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBS8</accession>
    <name>E9GBS8_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX83011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_223560"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2063790_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX83011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="119" mass="13539" checksum="AB62E41F215C9331" modified="2011-04-05" version="1">MNEINHEKKVDLRQQLVSQTENVIGAQWLRRYRLLPVYFREICIKLASSSYQVSNTLAYDRFDEKSYFEEKGQGPNSQQGSLFANPLAATLQSPCLLPYTGPIDLRVTLSLLITSTVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDL2</accession>
    <name>E9GDL2_DAPPU</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX82103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82103">
        <property type="protein sequence ID" value="EFX82103"/>
        <property type="gene ID" value="DAPPUDRAFT_241171"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241171"/>
    <dbReference type="HOGENOM" id="CLU_2294435_0_0_1"/>
    <dbReference type="OrthoDB" id="266752at2759"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX82103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="101" mass="11601" checksum="9555D89E6D7A9675" modified="2011-04-05" version="1">MVDTKPQSCLFTTQQPVTSQPRLQNFTPQLMMLTSYIIEELADYTDVSKYYITKSPECYTATYAALAYCTEAPTYYNTEARKFYTATYAAPSHYATKYYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDQ1</accession>
    <name>E9GDQ1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX82118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX82118"/>
    <dbReference type="EnsemblMetazoa" id="EFX82118">
        <property type="protein sequence ID" value="EFX82118"/>
        <property type="gene ID" value="DAPPUDRAFT_302532"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302532"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1116708_0_0_1"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="PhylomeDB" id="E9GDQ1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240237" description="Peptidase S1 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX82118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="249" mass="26531" checksum="7E09347FBAD65822" modified="2011-04-05" version="1">MRYILLLSLILCGLLARGLCEDSGEVDSIIGGAVAAKGQFPYMVYFRNQVTGKLFCSGTLITPYKVLTTAWCFPSFLPSVPITAWMNTVSLIPDVDRVVRAVVRVVRAPDYNPATGMHDIAVVTLDAPVTFVPPVRLGFGLYFNSGLSAGIVGWGYSGATQLTTYLRSSYITIQPKSVCMTAFGNPNFGSQFFICAASPGVGSCSLDAGSPILLNGYQIGISSQARCGGGEPVVGVDVRSYEAWIKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9GG00</accession>
    <name>E9GG00_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_242150</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Zdobnov E.M."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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    </evidence>
    <sequence length="447" mass="48208" checksum="FFFE754E93C8CB3F" modified="2011-04-05" version="1">MPALYEAKQKTKLSLARPNQKNIVLVDAVRTPFLLSGTSYAKLMPHDLARNALLGLVQKTGVPKEIVEYIAFGTVIQEVKTSNIAREAALGAGFSDKTPAHTVTMACISSNQAMTTCIGYMHSGVYDVCVAGGVEFMSDVPIRHSRKMRGVMLKANKAKTFGQRLSLLAQLDMKSLIPELPAVAEFSTGETMGHSADRLAASFNISRQDQDAFALRSHQLAHDAAEKGLLSDIVPYQVPGQDKPITRDNGIRVSTSEQLAKLKPAFIKPHGTVTAANASYLTDGASACLLMTEEKARQLGLKPKAYLRDFIYVSQDPKDQLLLGPAYATPRVLDKAGLKMSDIDVWEVHEAFAGQILSNLSAMDSDWFCKTYMGRPGKVGAPDIDKFNLWGGSLSIGHPFGATGVRLAIHAANRLIHEDGKYACIAACAAGGQGVGMIIERHPDGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9GI35</accession>
    <name>E9GI35_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_318175</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732545">
        <property type="protein sequence ID" value="EFX80946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80946">
        <property type="protein sequence ID" value="EFX80946"/>
        <property type="gene ID" value="DAPPUDRAFT_318175"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_318175"/>
    <dbReference type="eggNOG" id="ENOG502SPGA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030601_0_0_1"/>
    <dbReference type="InParanoid" id="E9GI35"/>
    <dbReference type="OMA" id="NINIYED"/>
    <dbReference type="OrthoDB" id="1339759at2759"/>
    <dbReference type="PhylomeDB" id="E9GI35"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="577"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX80946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="617" mass="71566" checksum="DD67540A4A8AC774" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9GI71</accession>
    <name>E9GI71_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 29</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein intersex</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_299749</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 29 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732546">
        <property type="protein sequence ID" value="EFX80823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80823"/>
    <dbReference type="EnsemblMetazoa" id="EFX80823">
        <property type="protein sequence ID" value="EFX80823"/>
        <property type="gene ID" value="DAPPUDRAFT_299749"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299749"/>
    <dbReference type="eggNOG" id="ENOG502QRNJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101133_0_0_1"/>
    <dbReference type="InParanoid" id="E9GI71"/>
    <dbReference type="OrthoDB" id="1480686at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021018">
        <property type="entry name" value="Mediator_Med29_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28314">
        <property type="entry name" value="PTHR28314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11568">
        <property type="entry name" value="Med29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX80823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="216" mass="24014" checksum="92C8D6159252F9FB" modified="2011-04-05" version="1">MAMHMTGMSNQGMMNLTPLQQQQLLQQQQQQQQQQQAAANNPQQMLQHQQQSQPVPNQQAAANPNMPNPAAPNPAAEQQKLDHIAKVKTLLWPLKESLIASFKTAAQNFNQNGMIDFGTMKGTETNVPRFDKQLEEFYSICDQIELNLQAAIGCASQISTSQRHVPSQVSIARQEPVINQEIMSYPNYVGVAKTQVAYVKDVIDTLNDAAQNLSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9GK54</accession>
    <name>E9GK54_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_26484</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732548">
        <property type="protein sequence ID" value="EFX80124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80124">
        <property type="protein sequence ID" value="EFX80124"/>
        <property type="gene ID" value="DAPPUDRAFT_26484"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_26484"/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="259" mass="29253" checksum="79EAEF1759890A89" modified="2011-04-05" version="1">MIRTITNRFSWKFGRCLTQTCSITSDTSHCQNATALKVNQPTELKESELKEITNPLRFPDYFGVRNLFRLKDLFDAKVHYGHKDGTLHPNMKPYIFGSRLGHIIFDLDKTTELLQDALNFTAHIAYKGGIILFVSHYPQHTLTVENAAKEAGEYAHAREWDFHLLTNSEKIYKGVTRLPDLIIMVSTLNPQMQEHTAVRDAAKMCIPTIGIVDSNSNPNLITYPVPGNDDSPTAVQLYCNLFRDAILLGKSKKSEIPSS</sequence>
</entry>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX79094">
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QWMR">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="EMBL" id="EFX79094.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
    <sequence length="1215" mass="134133" checksum="9999FD94AEEFD8BB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9GNA0</accession>
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            <fullName evidence="1">YccV-like domain-containing protein</fullName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732554">
        <property type="protein sequence ID" value="EFX79070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79070">
        <property type="protein sequence ID" value="EFX79070"/>
        <property type="gene ID" value="DAPPUDRAFT_245401"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_245401"/>
    <dbReference type="HOGENOM" id="CLU_021098_1_0_1"/>
    <dbReference type="InParanoid" id="E9GNA0"/>
    <dbReference type="OMA" id="IAREFTH"/>
    <dbReference type="OrthoDB" id="251112at2759"/>
    <dbReference type="PhylomeDB" id="E9GNA0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="SSF141255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YccV-like" evidence="1">
        <location>
            <begin position="316"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX79070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="442" mass="50091" checksum="217A932770416FF9" modified="2011-04-05" version="1">MAALRLNLAQEVKETVGMMSSVCYPLGEMALPMGPVNKWIISAHPIPNFIEAELCQLLSTSKMNDNLALNYYAKALSESFWMKKLDQQWKDYLSQPECQNSLLGGAVLFSQCIQGNYLCSRNVEPLMKITTERVLENRTGSAILISIVYQEVARMMGLRCEPIDCGGQILLRFRECFERNVDSNCYLIDVREGGSLIPGSPAIIGQPVVSAECIFQRILKAPITTYQEFFDDFDFLEKNSLKFFRLASVISPRVTRFVLDYGKLSASFGIHLDDAIQLLQSAGLHGDPVMADCITKQREKYAEILLAKIVCPRLPSIKYAVGLVMLYSYIACGIKKSQPCVIVSWDAKFQKSEEWLTWPSTKNLDQPYYRILGPKIEYGKLYVAQETLELHPVGVAIQHEELCIHFERFDGRRYLPNTEKKAQYPEDEDVAISLIKSLDDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9GNA9</accession>
    <name>E9GNA9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_245412</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732554">
        <property type="protein sequence ID" value="EFX79062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79062"/>
    <dbReference type="EnsemblMetazoa" id="EFX79062">
        <property type="protein sequence ID" value="EFX79062"/>
        <property type="gene ID" value="DAPPUDRAFT_245412"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_245412"/>
    <dbReference type="eggNOG" id="KOG1943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2815038_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GNA9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="PTHR12658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX79062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="67" mass="7523" checksum="BA80F8EDB2E8987C" modified="2011-04-05" version="1">MELFSLWESDMAWHGGCLALAELARHGLLLPQRLSSVLPFMEQAMLYDEFRGNFSVGSAVRDAACYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9GNE5</accession>
    <name>E9GNE5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_319960</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732554">
        <property type="protein sequence ID" value="EFX79042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79042">
        <property type="protein sequence ID" value="EFX79042"/>
        <property type="gene ID" value="DAPPUDRAFT_319960"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_319960"/>
    <dbReference type="HOGENOM" id="CLU_683835_0_0_1"/>
    <dbReference type="OMA" id="NWQGNNN"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241367" evidence="2">
        <location>
            <begin position="35"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX79042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="403" mass="37731" checksum="53CCA29FA19F17FC" modified="2011-04-05" version="1">MMVKVRPAQHFHTTMMIRSYSLLVVMLIVHYGSSAPAPQSSSTSNVGSGLTNLNSNLLGSSTNPGLLNGGLGTGLGFNGLNSFGGFGGLGSGGFGNGIGGFGTGIGGFGTGIGGFGNGLGGFGNGIGSFGTGIGGFGNGIGGFGNGLGGFGNGLGGFNGLGGGLSGFNGLNSFGGLGGGLGSGLGFGGLGGGLNGLNSFNGLGGLGGIGTGLGGGLGNFGTGLGGGLGGFGTGLGGGLGGFGTGIGGLNGLGLGNSGLLGGGLGGFGSLGGFGGNGLLGTGSLINSGLLGTTGLTNGLGTVGSNFGLGSGLGLGSSFGTGFGLGNLGGGSFRSLPDLNRMSPLLNTMVGGSSLTSSDQHVNNLVNRIRAIQQEFAANPSSSSSRSISSFGDFRSFDPTNDKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPZ2</accession>
    <name>E9GPZ2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DAPPUDRAFT_320485</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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</entry>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
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                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Shiga Y."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <sequence length="156" mass="16814" checksum="FADBBEC08E26DA7E" modified="2011-04-05" version="1">MASVDSGAASNSEEHCEEIDVEKDAAGTSSANANRCNKASAGNNLPWNPEKKDATPYSVYVPYKCLMGCHNNIVTVFNSTLKNARRHVATFHNVLLPRFNASFTAGRQSSNVNGKQLLVATMNKGLVNLNNSPSTITPIVMQSQLDDQIMVGTISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZ20</accession>
    <name>E9GZ20_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_250656</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732576">
        <property type="protein sequence ID" value="EFX75253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75253">
        <property type="protein sequence ID" value="EFX75253"/>
        <property type="gene ID" value="DAPPUDRAFT_250656"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_250656"/>
    <dbReference type="HOGENOM" id="CLU_3070814_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="53" mass="5979" checksum="34BEA138ECDE00FB" modified="2011-04-05" version="1">MKQRLCQLGKKNQVSFVLFLATWGSTVGTPMAESFMKTATRESQDGRRRLGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZD4</accession>
    <name>E9GZD4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_323649</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732577">
        <property type="protein sequence ID" value="EFX75132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75132">
        <property type="protein sequence ID" value="EFX75132"/>
        <property type="gene ID" value="DAPPUDRAFT_323649"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_323649"/>
    <dbReference type="HOGENOM" id="CLU_1788799_0_0_1"/>
    <dbReference type="OrthoDB" id="1771703at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="145" mass="16226" checksum="362A7D760FAF6727" modified="2011-04-05" version="1">MVSSENNQLVATHYSEDQYYVMEQSGTSAGSPIPRTTLARLEIECRPAINMDKGKTLKKKGIVAERALQHTSSSSISRPSTPLTSNSSPEPQDAFNVWKEKRDSSTLRQVMKKTKYSLCDLEETTAQSRLTEQRLKVLSSAMDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9H2Q6</accession>
    <name>E9H2Q6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_324793</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732586">
        <property type="protein sequence ID" value="EFX74019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74019">
        <property type="protein sequence ID" value="EFX74019"/>
        <property type="gene ID" value="DAPPUDRAFT_324793"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_324793"/>
    <dbReference type="HOGENOM" id="CLU_2471359_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX74019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="88" mass="10236" checksum="DECFE5150B7052F7" modified="2011-04-05" version="1">MESINRKVNAKFLDHPGLIAWIEFNKVFENVTASELKQLIEGQTIRKPFTKMQLDFKAGMTRITILQNEQRTNSISIEFFLDSVSKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9H3J5</accession>
    <name>E9H3J5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_8266</name>
        <name evidence="4" type="ORF">DAPPUDRAFT_9256</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733106">
        <property type="protein sequence ID" value="EFX63345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732589">
        <property type="protein sequence ID" value="EFX73692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX63345"/>
    <dbReference type="EnsemblMetazoa" id="EFX63345">
        <property type="protein sequence ID" value="EFX63345"/>
        <property type="gene ID" value="DAPPUDRAFT_9256"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73692">
        <property type="protein sequence ID" value="EFX73692"/>
        <property type="gene ID" value="DAPPUDRAFT_8266"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_8266"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_9256"/>
    <dbReference type="eggNOG" id="KOG2135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203580_0_0_1"/>
    <dbReference type="OMA" id="WLTMELE"/>
    <dbReference type="OrthoDB" id="1572864at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="PTHR14398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010831025" description="PWI domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX63345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX73692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="70" mass="7854" checksum="20CE2FEE3030693B" modified="2011-04-05" version="1" fragment="single">KMMIENPEALKLWLTAALAPLCDADPVVLAKHVLALLNKQIPDSELRGAMFDELDVFLQQETKGFVDQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9H3R3</accession>
    <name>E9H3R3_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_227079</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732589">
        <property type="protein sequence ID" value="EFX73561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73561">
        <property type="protein sequence ID" value="EFX73561"/>
        <property type="gene ID" value="DAPPUDRAFT_227079"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_227079"/>
    <dbReference type="HOGENOM" id="CLU_944167_0_0_1"/>
    <dbReference type="OrthoDB" id="1807672at2759"/>
    <dbReference type="PhylomeDB" id="E9H3R3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX73561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="257" mass="28820" checksum="088A6A636528E7CF" modified="2011-04-05" version="1">MPTATRHPQTTILVPLDSLELTDNQTSLEDVHPHDSLEFSRRLVKRDLEFALLDQSTSNGSLVLVLTDDGLSLEDVAFVEQEDQANPTITANHLPQDDLLHHLRIDSLEVVDDFDKRHVPAGDAGLLIVQGADGSEHAFLTDGHHFDDYSLEVVSNHDEQVSLLSALDQQPLTGVFTHPLSDDLYLVKEYLGDYYLWEMEDELARAYLSQSVNLNDPIVFHLTDDRRPKKLSAVHFAQFTPVQSVLNDRIHATSPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9H415</accession>
    <name>E9H415_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ty3_capsid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_253027</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732590">
        <property type="protein sequence ID" value="EFX73437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73437">
        <property type="protein sequence ID" value="EFX73437"/>
        <property type="gene ID" value="DAPPUDRAFT_253027"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_253027"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063311_1_0_1"/>
    <dbReference type="InParanoid" id="E9H415"/>
    <dbReference type="OMA" id="ARWISRY"/>
    <dbReference type="OrthoDB" id="1639793at2759"/>
    <dbReference type="PhylomeDB" id="E9H415"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043227">
        <property type="term" value="C:membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045358">
        <property type="entry name" value="Ty3_capsid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19259">
        <property type="entry name" value="Ty3_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="SSF57756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ty3_capsid" evidence="2">
        <location>
            <begin position="18"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX73437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="372" mass="42720" checksum="0DA247E976009610" modified="2011-04-05" version="1">MADALQDLITALNRREDTQAISSFSGNATDQYISSWLSEAEAIAIIHNWNDDVKKQNFASRLKGPALKWHSQRTRAHPNEAYTAWKQALKDHFKHPADRDKQIQKLENLTQKPNQPVRMFIDKINSTYNAIYDDTGNNNLTIKNDLLVKILLRGILKPIKTLMVLNQMLPEVTTWDDAQRAALRCETTLYKTQTSNGVLELPTFTSSNIDTLTATALQQQHQKIEELQSKLSKINFIGESPEPKEDTIFYLGPNQRGRPPQRNQPNTAVRWSDNTNNYPNSEQRYRSQSRDRQYPNSSNNGYYQPQPQAPQQQYNQRPKSPANRPNTPGASSRSNSRNNDPQNLQCHRCENFGHIAAECRTKDPKRLRRPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9H4Q9</accession>
    <name>E9H4Q9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_109958</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732592">
        <property type="protein sequence ID" value="EFX73315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73315">
        <property type="protein sequence ID" value="EFX73315"/>
        <property type="gene ID" value="DAPPUDRAFT_109958"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_109958"/>
    <dbReference type="HOGENOM" id="CLU_581744_0_0_1"/>
    <dbReference type="InParanoid" id="E9H4Q9"/>
    <dbReference type="OrthoDB" id="1282076at2759"/>
    <dbReference type="PhylomeDB" id="E9H4Q9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX73315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="470" mass="53633" checksum="F57C88C31DFBAD14" modified="2011-04-05" version="1">MTSAVLERQCVIHVIDCSETIKILGENQLKKCQDAQLVYKFRENSNYSKITVPTFIDNYQRYHPTCYKIFISVSIKEVLSGLQRQNVLDQAANQNSSQPDQPSTSETSRSAMTTTPGHSRALRSGKKTNTVNTRTRVFPKKCIFCSKSRTHPRKSTVVLDASTKGPTSVDKFCLRTNSWSSRTASMTGRRPQLNAGIRVPKADQSMEQHATNGNTSPRGRFEQALSLCPFISMVSIFAVKGLRDVDLLSLTALKKLNRLHIYRHAKGEKAEITFVGGVVPLLMTIGSSLELLDLTFFYTIDYWTVIKFCPNLISLIVNDHSERFSALPKNEIPHCRKDRERFTLKRLKELNCAYSLPPDILHFLFSFPLLEKFSITHGTTLTDEFLIDAVKSHRFQNLKELLLRHCNFVTKKGINAFMIEHNALEYISLHFCNKVSVNDIGDWQLLARQNNWKLNLDFKNSDVLRLRYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9H7X0</accession>
    <name>E9H7X0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_189045</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732602">
        <property type="protein sequence ID" value="EFX72169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72169"/>
    <dbReference type="MEROPS" id="A01.009"/>
    <dbReference type="EnsemblMetazoa" id="EFX72169">
        <property type="protein sequence ID" value="EFX72169"/>
        <property type="gene ID" value="DAPPUDRAFT_189045"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_189045"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_3_3_1"/>
    <dbReference type="InParanoid" id="E9H7X0"/>
    <dbReference type="OMA" id="SLCDDCQ"/>
    <dbReference type="OrthoDB" id="1619495at2759"/>
    <dbReference type="PhylomeDB" id="E9H7X0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008219">
        <property type="term" value="P:cell death"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="PTHR47966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241585" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="66"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX72169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="391" mass="42514" checksum="7D0F7C5F7208BB0C" modified="2011-04-05" version="1">MKKIFVLFALVGLSAAAKLLSIPLERLPTARSSMSLVEQSMERTRNRYSSGKILTEDLRNFQDSQYFGPITLGTPPQDFTVIFDTGSANLWVPSSQCSEENLACKVHNQYNSSLSDTYKPNGTEFSIQYGTGAMDGFLSTDILGVAGAQVMDQTFAEAVNEPGVTFVAGRFDGILGMSYPNIAVQGVVPMFQNMMAQGLVDEPVFSFWLNRDASDPVNGGEIVFGGTNPDHYVGEINYIPVTRKAYWQFRADGLMIEGIPEYPFCDGGCEMISDTGTSVIAGPAEEVNLLNRLLGAINIINGEAVISCLRIPYLPPITITISGLPYTLEGEDYILKVDDPTTNTSTCISGFLGLDIPPPSGPLWILGDVFIGKFYSIYDFGMDRIGLATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9H8P6</accession>
    <name>E9H8P6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_326757</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732605">
        <property type="protein sequence ID" value="EFX71907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71907">
        <property type="protein sequence ID" value="EFX71907"/>
        <property type="gene ID" value="DAPPUDRAFT_326757"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326757"/>
    <dbReference type="eggNOG" id="ENOG502S3Y6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_730095_0_0_1"/>
    <dbReference type="InParanoid" id="E9H8P6"/>
    <dbReference type="OMA" id="ERSERWM"/>
    <dbReference type="OrthoDB" id="892977at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX71907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="379" mass="41387" checksum="5703A9E90178A8E0" modified="2011-04-05" version="1">MVRGGQYSDESDSDWDSLSQAVVPPPPASSTATEPSTESAQPADERPKLVPAFNEIVRPNSDSLRSMSAASTAKGPLTFIDRRLNGDTVASPQPTRDSSPVVSLRTTTKKELQPHQVQHRTSEAQIFDEELPVIATDIKDVEFQPTTPIGQQQQQQPTTTKQFKSPVLMSRRPTDNSISYSSSDGFDNVAFEGPSSGMYSCSPPIERAKTASVQQHQPLPKPDETIEIFPYDKTNPEFNQVSERRRRAMADGLSETVFEVSSRFCSELTAVIGLPFIIALAVLLQSLRFVTAGLLRPLLIGLVMGISDGLVKPLLAAFHNGVVVPFAAFLHNVASAVKTSLVPVAGIILLMTEPLGRLLQSCRLIDIHHHHHKPIVRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HAN1</accession>
    <name>E9HAN1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_309146</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732612">
        <property type="protein sequence ID" value="EFX71211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71211">
        <property type="protein sequence ID" value="EFX71211"/>
        <property type="gene ID" value="DAPPUDRAFT_309146"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309146"/>
    <dbReference type="HOGENOM" id="CLU_1442469_0_0_1"/>
    <dbReference type="OrthoDB" id="544783at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX71211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="188" mass="21254" checksum="20A4BC2DC1FFE334" modified="2011-04-05" version="1">MTHLRRISLRYLANDTMIAALAKNCRHLQEMDVCYSIDVTDSGMKLLCDPDLIIKESTAQEPHTSARGWKSERERCRKISAPSASHNHVSGCMVWFPRLLVRGIRRYSVVDEKQVNNNNNNRELNLVYDDDNSPQWPEDEEQEMMADGEIPPTCIKSLRRLEILGTSITPSGIQMISAAASPVITIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9HAU3</accession>
    <name>E9HAU3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_60650</name>
        <name evidence="3" type="ORF">DAPPUDRAFT_64995</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732713">
        <property type="protein sequence ID" value="EFX66169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732613">
        <property type="protein sequence ID" value="EFX71089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66169">
        <property type="protein sequence ID" value="EFX66169"/>
        <property type="gene ID" value="DAPPUDRAFT_64995"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71089">
        <property type="protein sequence ID" value="EFX71089"/>
        <property type="gene ID" value="DAPPUDRAFT_60650"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_60650"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_64995"/>
    <dbReference type="eggNOG" id="ENOG502S88E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065450_3_0_1"/>
    <dbReference type="OMA" id="NVHADNI"/>
    <dbReference type="OrthoDB" id="1459720at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX66169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX71089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="105" mass="11222" checksum="DC4B36EE892FF5A2" modified="2011-04-05" version="1" fragment="single">EPIAIISSNSEMNADGSYSFDFESADGTRVQESGNQKKVGPKPEDIGTVSRGSYSYTSPDGVVLSINWTADENGFQAAGDHLPTPPPMPEHVVKMLADLRARGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9HFI1</accession>
    <name>E9HFI1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_202808</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732636">
        <property type="protein sequence ID" value="EFX69502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69502"/>
    <dbReference type="EnsemblMetazoa" id="EFX69502">
        <property type="protein sequence ID" value="EFX69502"/>
        <property type="gene ID" value="DAPPUDRAFT_202808"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_202808"/>
    <dbReference type="eggNOG" id="KOG0990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_2_0_1"/>
    <dbReference type="InParanoid" id="E9HFI1"/>
    <dbReference type="OMA" id="TRTIFCG"/>
    <dbReference type="OrthoDB" id="1071197at2759"/>
    <dbReference type="PhylomeDB" id="E9HFI1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="39"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX69502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="330" mass="37563" checksum="CEB406F8C0B832B5" modified="2011-04-05" version="1">MTSSGNLPWVEKYRPKQLDDLISHQDIISTIRKFINENRLPHLLFYGPPGTGKTSTILACAKELYTPQQFNSMVLELNASDDRGINVVRNQIMSFASTRSIFKSGFKLIILDEADAMTNDAQNALRRVIEKFTENVRFCLICNYMSKIIPAIQSRCTRFRFGPLKSDQILPRMNYVIEEEKIKVTEDGRQALLSLAHGDMRRVINILQSTSMAFDEVNEDHVYTCVGHPLKSDIANVVSWMLNEDLTSAYSKIRDLQTFKGLALQDILTETHLYVHKIEFPPNVRVFLLEKMADVEYRLSAGCSEKLQLGSLLAAFDSIKYLIAKEVSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HFV5</accession>
    <name>E9HFV5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_258681</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
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                <person name="Oakley T.H."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Thomas W.K."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Arnold G.J."/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX68428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="383" mass="43093" checksum="BCE0AE8F3B467481" modified="2011-04-05" version="1">MATCDVAPEGISDQLMFSQLFFTSRLSPLVSPKLPQCLLFTIRSLGIALRPPTKRCRRGGESARRARLKKKFLHCSLINARSILSNKSVIQHHIIFHDLDLLAITESWLREDEGDEILRELCPAGYVSLQKPRVGRRGGGVAIICRDSIRIRLLHLDYAATSFEFMAASLTINSTCFVLLIIYRPPSSKPSQFIDEFASLLEVLVPAPGLLLIVGDFNIHVDESLSSLSQSFTSLIGSFDLRQHVSDASHVGGHVLDLVLSRAADNFLSKCYVSDLITDHYAVHWYAKAHRPMRPVKAVQFRKLNIRDSGRETRSSSKLLLHSPRTRTKGFGDRAFSAAAPRIWNSLPLELRLLALFPYSSRFSLTQFRCHLKTFLFRNAYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJJ0</accession>
    <name>E9HJJ0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G_PROTEIN_RECEP_F1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_330424</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732662">
        <property type="protein sequence ID" value="EFX68123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68123"/>
    <dbReference type="EnsemblMetazoa" id="EFX68123">
        <property type="protein sequence ID" value="EFX68123"/>
        <property type="gene ID" value="DAPPUDRAFT_330424"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330424"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_957310_0_0_1"/>
    <dbReference type="InParanoid" id="E9HJJ0"/>
    <dbReference type="OMA" id="ATIAFCH"/>
    <dbReference type="OrthoDB" id="609835at2759"/>
    <dbReference type="PhylomeDB" id="E9HJJ0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F1_2" evidence="9">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX68123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="291" mass="32307" checksum="D98712F378C67596" modified="2011-04-05" version="1">MEIRSYTWPLGNSPVSCKMVGSLQAVSIFVSTLSITAIALDRYQLLVYPTKKSFQLTGALLALGGIWILGVVLALPLFIVRTLQHHEIPIPNSPISSVDYCLEEWPNERGRSLYSIGSILIQYALPIITVSVAHARICNKLQVRMASMNHQQATRQQQQKQPPQPPLNNAPGPSTSNGHPLQNSATMLIVYAVCHMVGMSLACANPLLYGWLNDNFRKEFQKIGTSFVARSNNNRATTQSMRQRAKMVVQQQTATDKRPNSKAVGLHKHSTALSKKRCVEKGKHDHALKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKT0</accession>
    <name>E9HKT0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_115262</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732671">
        <property type="protein sequence ID" value="EFX67663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67663">
        <property type="protein sequence ID" value="EFX67663"/>
        <property type="gene ID" value="DAPPUDRAFT_115262"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_115262"/>
    <dbReference type="HOGENOM" id="CLU_1637118_0_0_1"/>
    <dbReference type="OrthoDB" id="884602at2759"/>
    <dbReference type="PhylomeDB" id="E9HKT0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="162" mass="17889" checksum="F6ECAFCD47CE598B" modified="2011-04-05" version="1">MELSVETIYFLSSLIVSVQRKKATSRPRYSAAVYQGRSSGSSPATYKIFPAAENTNGIKINGSWNEIIGALTKGEADFGLVPVAVSLERYEAIEFCGRVGGDYTGILIKYPEGRISFTSAFDVFSTGRIVIECPDMDRMDHFRRSGRCSFHCSGLLFKNIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKY5</accession>
    <name>E9HKY5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_63811</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX66399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="81" mass="9012" checksum="7BBFD3365CD96E15" modified="2011-04-05" version="1">MECPELDTRGNIFANGYLLSELGINNDLDVSFAYRNSYCLAMTLPPRDNPKGLADEPVDGVGSLSLPEKDAFHMQHKIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPQ8</accession>
    <name>E9HPQ8_DAPPU</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX66267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66267">
        <property type="protein sequence ID" value="EFX66267"/>
        <property type="gene ID" value="DAPPUDRAFT_263423"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_263423"/>
    <dbReference type="HOGENOM" id="CLU_1062682_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003238494" evidence="2">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX66267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="262" mass="27661" checksum="402CADFE1B148B89" modified="2011-04-05" version="1">MCCNGHWIAVLVVVCLMQLLVDAQVYYPQPVPVTTTTTTTTTAAPTTTTTSAATTTVAPLPTTTTLDPLAPGSLALMNSMMANLMNIMSMYPPPPPPPPPMAYPPPPPPVNPAGINYYNSPPVDAAPLPPSNYYYAPPAPYGGMPPAPYAQQQQASSYVTTVRPPAPYGVVPSSSGSPYYPPPPTPYGSTSFGPSSVYGMGFRPTATYYGNAAGYQAYSAAQQQPYSNNYAGSYYPPQQQPMNIAYHGTACSSLEMVVLQLV</sequence>
</entry>
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    <accession>E9HQK2</accession>
    <name>E9HQK2_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX65983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65983">
        <property type="protein sequence ID" value="EFX65983"/>
        <property type="gene ID" value="DAPPUDRAFT_116803"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_116803"/>
    <dbReference type="HOGENOM" id="CLU_1157432_0_0_1"/>
    <dbReference type="OrthoDB" id="1779341at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX65983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="202" mass="22748" checksum="431E61560BEDDB58" modified="2011-04-05" version="1">MSSLIAVVNVEELHVVSLAEKLLSPYLLNLPPNEGQRSVLIDSEIFSADGLLNLKCVQQRLNFKRVCLHHKNVEERHIDSAVEKLSPPCLLNLPPDEEQQSMLNDSEMFCSDEFLNVETCSTTPESEASLLVPEVFVEEYTIAIAEKLLFPSLDSLSSYEGKQTIMPIDSEMFCDDDFTNVETCSTTLEQLMFSTVALIRRE</sequence>
</entry>
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    <accession>E9HRP1</accession>
    <name>E9HRP1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_264481</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732739">
        <property type="protein sequence ID" value="EFX65592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65592">
        <property type="protein sequence ID" value="EFX65592"/>
        <property type="gene ID" value="DAPPUDRAFT_264481"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_264481"/>
    <dbReference type="HOGENOM" id="CLU_1751513_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HRP1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX65592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="137" mass="15512" checksum="2690817573BBB068" modified="2011-04-05" version="1">MPRGRNSELSRELRRSVLEERQLAATIERELARQRRRVAHQEPYRRVEFRPVVRPYIPLERQPQQSVAHGGSVPPPPLRADELPTQRPEIATFAHNAGAVAHGLATARLYIPAVHPAQESAEDVLQLAIDEEIPLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9HS71</accession>
    <name>E9HS71_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_117297</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
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                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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    <sequence length="275" mass="31299" checksum="330D26B8676F0526" modified="2011-04-05" version="1">MERPKRARKQPIWFADLEVSAESGKVVKGRGGRVGREHAAENVAVVANRPIRPMALETTKPIGAFDLNKLTPEGGFTVDNMHRISSRGSIPVALEEPNLVPTPDDDSDDNGLSGGLSEKSEEKNEDETDYGIKIFYLQHTYQHLTHLLTDENESGVREDESESASRRRREHQQSTERQSLSRSPENYENEEDEAEEATKSDISLGDEPKRWKMVYNAGKKLSSILVDRKNGYKFRVWKVLSNGILYRCTYRPKNNPCKCSVLVIYRDAKREGLRY</sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX65093.1"/>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="154"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="167" mass="19322" checksum="4ACF3A45A54C29C2" modified="2011-04-05" version="1">MAAEKDGRNAVYQYLRLYNHENRKKVYKTLDTRFYFNNSDRVEKAIAAMNLMSDETSQKGNYEDMPDLEEGPPIKHIPIPPQKVNENIYPARTEMLRLDDGAPSLKLRNFKRLIDKAKSKLPPPPGYRRDYSLITSESDSDIEKNIIGDNKITPSEDEDDNDLNELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
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    <protein>
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            <fullName evidence="5">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:structural constituent of chromatin"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="PTHR12040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF101546"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="442" mass="49603" checksum="DD14891F8AB098D5" modified="2011-04-05" version="1">MGGVDTANQLRSYYERDLQMPFLEFKRNVTMGLLSHALNENKNKAGRAGRMMPTIHPSAEPGAKRQAEYTCQVVKESGPFVKFQLEWHLPQHSTNRMHDILSKPGAINTLHLKIPKLQESDSGKYRSEVYYYHQSYLKSSEERVALENALQHIGNLLLKKFQLFCSNLIAKNIGLMMFIYQTMPSNHQTKIAKFCYATPELLQKAIGVSLKARSAWEKVPLNKKVDIFFKAGDLVSTKYRSQLNASTMLGQGKTVFLAEIDAACELADFLRFDIEGWKDLSPLFLTAIGGNLAYAPAIMGNVVLWKPSDTALLSNYIVFRLMEESGIPPGVVSFLPAEGPSFGRAITNSTHLSTINFTGSVLTVHWLWKQVGENVDRFRNLPRLVGECGGKNYHLVHSSANVEHVVNSTLRGAFEYSGQKCSATSRLYVPSSSWKQVRVKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9HUP7</accession>
    <name>E9HUP7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-related protein Rab-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_304534</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732818">
        <property type="protein sequence ID" value="EFX64533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX64533"/>
    <dbReference type="EnsemblMetazoa" id="EFX64533">
        <property type="protein sequence ID" value="EFX64533"/>
        <property type="gene ID" value="DAPPUDRAFT_304534"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304534"/>
    <dbReference type="eggNOG" id="KOG0093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_1_1"/>
    <dbReference type="InParanoid" id="E9HUP7"/>
    <dbReference type="OMA" id="WQKDASD"/>
    <dbReference type="OrthoDB" id="1218073at2759"/>
    <dbReference type="PhylomeDB" id="E9HUP7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031489">
        <property type="term" value="F:myosin V binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01865">
        <property type="entry name" value="Rab3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037872">
        <property type="entry name" value="Rab3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX64533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="219" mass="24969" checksum="26BA8DC91D53546B" modified="2011-04-05" version="1">MSVGQDNRWQKDAADQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRQDKRVKLQIWDTAGQERYRTITTAYYRGAMGFLLMYDITNEESFNSVQDWCTQIKTYSWDNAQVILVGNKCDMEDERVISYERGKQLADQLGLEFFETSAKENINVKAVFERLVDIICDKMSESLDSDPNMVNSSKGTRLTDQTPAPNAGACQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9HUW7</accession>
    <name>E9HUW7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_334163</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732826">
        <property type="protein sequence ID" value="EFX64465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64465">
        <property type="protein sequence ID" value="EFX64465"/>
        <property type="gene ID" value="DAPPUDRAFT_334163"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_334163"/>
    <dbReference type="HOGENOM" id="CLU_159524_0_0_1"/>
    <dbReference type="OrthoDB" id="1916106at2759"/>
    <dbReference type="PhylomeDB" id="E9HUW7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX64465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="106" mass="11979" checksum="E19A39F7D549CE63" modified="2011-04-05" version="1">MPKPSGSRFLLYIDSSGQTSLENMTHQFRVDTDRAVQFISIDGRAITDTVLDGIFTREKDAENNAVKLSFVICDAVRCNGQDITKMNVFQHIAFVKVINRYVSFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9HUZ5</accession>
    <name>E9HUZ5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_118182</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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    </feature>
    <feature type="domain" description="FSA_C" evidence="1">
        <location>
            <begin position="72"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="140" mass="16396" checksum="21D7FEE2DEA79EF5" modified="2011-04-05" version="1" fragment="single">KPSVDCSFITDFEDHIFVTVDADAFFFLHDLISSYVREKERVVRSPAINNAPLSLQLTNEDEKKRRLLEQIDWRNYECKTWHLEPTVRLLSWAGKRIEPYGVEYILNKLGFSQARTTIPKWVQRGAMDPLDKILSLVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HXU1</accession>
    <name>E9HXU1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_335453</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733075">
        <property type="protein sequence ID" value="EFX63438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63438">
        <property type="protein sequence ID" value="EFX63438"/>
        <property type="gene ID" value="DAPPUDRAFT_335453"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_335453"/>
    <dbReference type="HOGENOM" id="CLU_057396_0_0_1"/>
    <dbReference type="InParanoid" id="E9HXU1"/>
    <dbReference type="PhylomeDB" id="E9HXU1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="253" mass="26923" checksum="663AA1390CB0AB5F" modified="2011-04-05" version="1">MPIAPTVDADLFPELAQRPTTSTVVVLDGAPEDPISKPDETESSSDTDSDAEDTNCVGSSVASKSVKKKKIKHTREFRDQQKQSKKRSRTASPCASGEVAEEIVSGVAQLVELGSQTREVPFSIPGVNINSFPALSGGNDVPPAANAPGVPSIPSTIDQMDNEVVEEMDASEVVSISNPEEDISFSGGSIQPGQRPLNSQEASHVSETQESLGVPLGTPSTPIEDKTLKAMEAVRRKKAHDNKTQPSKPKFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9HYG6</accession>
    <name>E9HYG6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_268862</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733157">
        <property type="protein sequence ID" value="EFX63214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX63214">
        <property type="protein sequence ID" value="EFX63214"/>
        <property type="gene ID" value="DAPPUDRAFT_268862"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_268862"/>
    <dbReference type="HOGENOM" id="CLU_1246506_0_0_1"/>
    <dbReference type="InParanoid" id="E9HYG6"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="PhylomeDB" id="E9HYG6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX63214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="222" mass="25236" checksum="DDBF42F4EFB5B196" modified="2011-04-05" version="1">MHFANFAACVELSTNSGPIRISSIYLRPSIPDFSAAVTLIFEAVSSPFVIIGTDANAKSQLWNSSSCDKRGSEFESILANFKLNVINRPSTDLDFIPSGTSFVDLTLAGDKVRFHRWFYLATPSLYDHPYVFFEIDHAEFEKPQRKPFCRSKPKLSWVNRDLFTLKLKKCSILLANPYSSGLLCVSGGLDFQSCFRDFIERECRQNLSTPLQWQEEYAVVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZN2</accession>
    <name>E9HZN2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_119850</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733380">
        <property type="protein sequence ID" value="EFX62798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62798">
        <property type="protein sequence ID" value="EFX62798"/>
        <property type="gene ID" value="DAPPUDRAFT_119850"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_119850"/>
    <dbReference type="HOGENOM" id="CLU_036338_0_0_1"/>
    <dbReference type="InParanoid" id="E9HZN2"/>
    <dbReference type="OrthoDB" id="1535084at2759"/>
    <dbReference type="PhylomeDB" id="E9HZN2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="SSF57756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX62798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="553" mass="61664" checksum="56B420E494ECCF5A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZS1</accession>
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            <fullName evidence="2">KH_dom_type_1 domain-containing protein</fullName>
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    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX62759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX62759"/>
        <property type="gene ID" value="DAPPUDRAFT_269774"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_079467_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HZS1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="154"/>
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        </location>
    </feature>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00013"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="275" mass="29959" checksum="03F53360B57DF583" modified="2011-04-05" version="1">MPDPAQSRSTGQEVVTDESYGFTLDFQIMEKCKNPRRSFFIPARERTKPPAPAAPKAQVHFPVGDVRYKNKPMSGYVVNSDGTQVIYGGAVPLTRKPTPAIPTNNTEAAGPPAFEQPKQKPCTTNGPVKTDDLVVTSTPIERVSLPGNRLMLKNVPGGDYGRIIGSGGSNIRRLFQIVARINTSPDGNFSFLITGNTEEVRQAAADDIVGGLTVTAEFSNTKLPKRIKNFRLNEIGRKYFVRINRPSDNNGMITLTGRLSSCQSAYAEIMGEAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9I076</accession>
    <name>E9I076_DAPPU</name>
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        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX62604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62604">
        <property type="protein sequence ID" value="EFX62604"/>
        <property type="gene ID" value="DAPPUDRAFT_270129"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_270129"/>
    <dbReference type="HOGENOM" id="CLU_495465_0_0_1"/>
    <dbReference type="OrthoDB" id="1300981at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0090630">
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </feature>
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            <end position="263"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="550" mass="59093" checksum="A1618486E96ACEF2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9I1Q2</accession>
    <name>E9I1Q2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
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                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_271062"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_271062"/>
    <dbReference type="HOGENOM" id="CLU_2335719_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="EFX62077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="98" mass="11142" checksum="17B2D148031723EF" modified="2011-04-05" version="1">MKWQKDVPGRGAMVVTADQISAALLVTGDTPVERRIQNILDALPYATEFTTQCLYRRELQKALKVTFPELVVGEERQFNHVDVEQDDEGFLAVRKAQH</sequence>
</entry>
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    <name>E9I2B2_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="3">
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        <lineage>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Tsuchiya D."/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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                <person name="Geiler-Samerotte K.A."/>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="EnsemblMetazoa" id="EFX60558">
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        </location>
    </feature>
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            <end position="178"/>
        </location>
    </feature>
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            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9I6G6</accession>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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            <begin position="391"/>
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        </location>
    </feature>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL736557">
        <property type="protein sequence ID" value="EFX60369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60369">
        <property type="protein sequence ID" value="EFX60369"/>
        <property type="gene ID" value="DAPPUDRAFT_277864"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_277864"/>
    <dbReference type="HOGENOM" id="CLU_1551449_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="173" mass="19729" checksum="7521FE70B931D05B" modified="2011-04-05" version="1" fragment="single">MQLARAIEFDAAAIYERLLAKQDYYESHGMLNEQGYFYLKVEDLQYETTLGEKAQRRIIAHLVKLKILQYKRAGLPAKRWFKIGDDEKTALEAILISSSKREELDPPIGSKAGEKYKDFDLAYYYEAVSLWSKGGGKKMVDWIACARGFMNRDKAEGKAKMSVSVILDDNAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9I6L8</accession>
    <name>E9I6L8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        </source>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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        <location>
            <begin position="1"/>
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        </location>
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            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="243" mass="26894" checksum="EC0F021E6A7CCF7A" modified="2011-04-05" version="1">MKFAVIFATAVACAMAGTQSSSSGTSVRNYSDGIMKRSSTSTLGNQNGQNPVVRKRRVNVLDANGKLVDFDDDDFQIITSDLTGRKFNFQSKQNTIPVNRFPVRPSNVGSVSTSGQATGDIIFVSDDSREIDDLDDLDDLDDLAIISPNRLSSFPFVNGQNAARLVSQSSIFNPSTSFVRTPLRPTRMKPRFVQSASTCTCPPQRESAFQFSRFPQQSFNRFSQFGRFPFVSSSPYVQFIFDD</sequence>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="6"/>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88837"/>
    <dbReference type="EnsemblMetazoa" id="EFX88837">
        <property type="protein sequence ID" value="EFX88837"/>
        <property type="gene ID" value="DAPPUDRAFT_304798"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304798"/>
    <dbReference type="eggNOG" id="KOG0967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_0_0_1"/>
    <dbReference type="InParanoid" id="E9FUX8"/>
    <dbReference type="OMA" id="WIKYKRD"/>
    <dbReference type="OrthoDB" id="274264at2759"/>
    <dbReference type="PhylomeDB" id="E9FUX8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006266">
        <property type="term" value="P:DNA ligation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="9">
        <location>
            <begin position="409"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="642"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX88837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="677" mass="75405" checksum="3CBE2D7EE36E6408" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9FY39</accession>
    <name>E9FY39_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_96517</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87468"/>
    <dbReference type="EnsemblMetazoa" id="EFX87468">
        <property type="protein sequence ID" value="EFX87468"/>
        <property type="gene ID" value="DAPPUDRAFT_96517"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_96517"/>
    <dbReference type="eggNOG" id="KOG1015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074202_0_0_1"/>
    <dbReference type="InParanoid" id="E9FY39"/>
    <dbReference type="OrthoDB" id="815681at2759"/>
    <dbReference type="PhylomeDB" id="E9FY39"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="PTHR45797"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="193"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX87468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="325" mass="37324" checksum="64CF4599DEEDCB56" modified="2011-04-05" version="1">MKMFSSDQPQSQTVLIVCPVNIILNWENEFAKWLPPESWNGCSQKDKVRSSEFRDRFLDPIDKGKLTDATDHVVIFMKQQSQLLHKLLRGLVQRFDLNVLSPYLPSIFEYVLSVRLSELQIKLYEHFLRYNANASPSRDSQGNRLFSHYHELGHLWAHPKALIGKLSVFSGDNGNDRSSSNAWWSQILLEQEDMTQLKFFIRANSLGKKVLIFSQSLVSLCLIEEFLAAEDRKNRAGLALTDKNPIGLLKLDVDYLRMDGHTTVEKRNSDCNMFNDPMNIRARVFLISTKAGGMGINLTAANRVIIFDASWNPSHDIQSIFRVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYH5</accession>
    <name>E9FYH5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NSFL1 cofactor p47</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">p97 cofactor p47</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_42769</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="244"/>
        </location>
    </feature>
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        <location>
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        </location>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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            <end position="284"/>
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            <begin position="1"/>
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        </location>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZ86</accession>
    <name>E9FZ86_DAPPU</name>
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        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87011"/>
    <dbReference type="EnsemblMetazoa" id="EFX87011">
        <property type="protein sequence ID" value="EFX87011"/>
        <property type="gene ID" value="DAPPUDRAFT_312502"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312502"/>
    <dbReference type="eggNOG" id="KOG3591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1251792_0_0_1"/>
    <dbReference type="InParanoid" id="E9FZ86"/>
    <dbReference type="OrthoDB" id="1187096at2759"/>
    <dbReference type="PhylomeDB" id="E9FZ86"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="PTHR45640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="48"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX87011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="187" mass="21365" checksum="336DDE5E901FCD06" modified="2011-04-05" version="1">MALWNIDPFFDMGMGWPRDPWAVYRQDPLNRWMESSLPSVLSAIDFAPTGTRRRSPIREVVSDENKYQVTLHLGDFKSDEINVKLVDRNLVIHAEHKEKPDEHGHISRNIKRSYILPRNTDFENLSATLSDDGTLMVCAQKKAVEPEKEREIEVKQLPPTSQQSVKSGQETEKGNVNIPVSREAGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZ97</accession>
    <name>E9FZ97_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DAPPUDRAFT_235589</name>
        <name evidence="17" type="ORF">DAPPUDRAFT_235633</name>
        <name evidence="31" type="ORF">DAPPUDRAFT_235635</name>
        <name evidence="18" type="ORF">DAPPUDRAFT_235671</name>
        <name evidence="19" type="ORF">DAPPUDRAFT_235694</name>
        <name evidence="29" type="ORF">DAPPUDRAFT_235741</name>
        <name evidence="28" type="ORF">DAPPUDRAFT_235770</name>
        <name evidence="20" type="ORF">DAPPUDRAFT_235794</name>
        <name evidence="27" type="ORF">DAPPUDRAFT_235799</name>
        <name evidence="21" type="ORF">DAPPUDRAFT_235871</name>
        <name evidence="26" type="ORF">DAPPUDRAFT_235878</name>
        <name evidence="22" type="ORF">DAPPUDRAFT_235943</name>
        <name evidence="25" type="ORF">DAPPUDRAFT_235955</name>
        <name evidence="23" type="ORF">DAPPUDRAFT_235966</name>
        <name evidence="24" type="ORF">DAPPUDRAFT_235969</name>
        <name evidence="15" type="ORF">DAPPUDRAFT_255864</name>
        <name evidence="14" type="ORF">DAPPUDRAFT_268986</name>
        <name evidence="13" type="ORF">DAPPUDRAFT_269644</name>
        <name evidence="30" type="ORF">DAPPUDRAFT_312356</name>
    </gene>
    <organism evidence="32">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 32" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX62825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX86974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX87017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX87259.1"/>
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        <property type="protein sequence ID" value="EFX87300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX87336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX87348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX87362.1"/>
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        <property type="protein sequence ID" value="EFX87383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX87415.1"/>
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        <property type="protein sequence ID" value="EFX62825"/>
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        <property type="gene ID" value="DAPPUDRAFT_235671"/>
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        <property type="protein sequence ID" value="EFX86919"/>
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        <property type="protein sequence ID" value="EFX87300"/>
        <property type="gene ID" value="DAPPUDRAFT_235878"/>
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    <dbReference type="EnsemblMetazoa" id="EFX87336">
        <property type="protein sequence ID" value="EFX87336"/>
        <property type="gene ID" value="DAPPUDRAFT_235799"/>
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    <dbReference type="EnsemblMetazoa" id="EFX87348">
        <property type="protein sequence ID" value="EFX87348"/>
        <property type="gene ID" value="DAPPUDRAFT_235770"/>
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        <property type="gene ID" value="DAPPUDRAFT_235741"/>
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    <dbReference type="EnsemblMetazoa" id="EFX87383">
        <property type="protein sequence ID" value="EFX87383"/>
        <property type="gene ID" value="DAPPUDRAFT_312356"/>
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    <dbReference type="EnsemblMetazoa" id="EFX87415">
        <property type="protein sequence ID" value="EFX87415"/>
        <property type="gene ID" value="DAPPUDRAFT_235635"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_235589"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_235633"/>
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    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_235969"/>
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    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_268986"/>
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    <dbReference type="eggNOG" id="KOG1756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062828_3_3_1"/>
    <dbReference type="OMA" id="PKKTEIC"/>
    <dbReference type="OrthoDB" id="1504122at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="Histone_H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="PTHR23430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone" evidence="11">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
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        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00125"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF16211"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87017.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87058.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87069.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87250.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87259.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87300.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87348.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87362.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="EFX87415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="126" mass="13511" checksum="3AB5861F1FD79657" modified="2011-04-05" version="1">MSGRGKGGKVKGKSKTRSSRAGLQFPVGRIHRMLRKGSYAERVGAGAPVYLAAVMEYLAAEVLELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIQAVLLPKKTDKPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="17" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    <sequence length="290" mass="32238" checksum="68EE8A5CB6470865" modified="2011-04-05" version="1">MHLLCNQFLTKRRAAVGRCMAGSTTGVPMSPGYSGYQTATPLPYYTTRTLTTSYYTEAPKYYTTKPSEYDRATTPMPRIITLPSATPPRQRILHDYVCCPIYYTESAATTPSLQLLHRVCSCYTESAAATPSLQLLHRVCSYYTESAATALMVGATTGVLMSPGVLMSPGVLMSPANTTTTPSLQLLHRVCSYYTESPAYFSTRTVEYYTGAPKYYSAPNYTATTEADKDYAAPTYYTEAVPSYNVEQKYYTDAPVYYTPAYATSSNNIEARKYSTEESSYYRATYDLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
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        <recommendedName>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dymeclin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG2225">
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    <dbReference type="OMA" id="WNGLLNY"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX86578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="657" mass="74746" checksum="4AF72D2F65C4E7C7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E9G266</accession>
    <name>E9G266_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DAPPUDRAFT_308494</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="13">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732530">
        <property type="protein sequence ID" value="EFX86357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86357"/>
    <dbReference type="EnsemblMetazoa" id="EFX86357">
        <property type="protein sequence ID" value="EFX86357"/>
        <property type="gene ID" value="DAPPUDRAFT_308494"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_308494"/>
    <dbReference type="eggNOG" id="KOG0430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_1_0_1"/>
    <dbReference type="InParanoid" id="E9G266"/>
    <dbReference type="OMA" id="IPGPNYV"/>
    <dbReference type="OrthoDB" id="48717at2759"/>
    <dbReference type="PhylomeDB" id="E9G266"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 13" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="14">
        <location>
            <begin position="170"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="1180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="706"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="849"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1007"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFX86357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1235" mass="135327" checksum="1DB68223B3C627AF" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6A0</accession>
    <name>E9G6A0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_238392</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX84897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84897">
        <property type="protein sequence ID" value="EFX84897"/>
        <property type="gene ID" value="DAPPUDRAFT_238392"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238392"/>
    <dbReference type="HOGENOM" id="CLU_1706014_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX84897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="154" mass="17890" checksum="4C4706703475CA32" modified="2011-04-05" version="1">MQRVRHKSVHKAEMPRRALVYYAIRPKVGDSPCRGLLGSYIYAYYYLINSLVLLYEKTFTAAKVKKCRASGKRGEIFINKIEKRWRPTTMYRRRRLKAKISAGHVPAAYAIKSPPSYLILYGGHRPLFNHFRFQLGSQSTMISLFPTPSCWTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6T3</accession>
    <name>E9G6T3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_238160</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="EFX85138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX85138"/>
        <property type="gene ID" value="DAPPUDRAFT_238160"/>
    </dbReference>
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    <accession>E9GA19</accession>
    <name>E9GA19_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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            <taxon>Arthropoda</taxon>
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            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX83786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83786">
        <property type="protein sequence ID" value="EFX83786"/>
        <property type="gene ID" value="DAPPUDRAFT_301647"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301647"/>
    <dbReference type="HOGENOM" id="CLU_253855_0_0_1"/>
    <dbReference type="OMA" id="YILAAPQ"/>
    <dbReference type="OrthoDB" id="1674752at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240749" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1408"/>
        </location>
    </feature>
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            <end position="70"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="1300"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX83786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1408" mass="152994" checksum="5A73F9628907BBBE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAC8</accession>
    <name>E9GAC8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GLOBIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_301607</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1 4 5">Belongs to the globin family.</text>
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    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    <dbReference type="PhylomeDB" id="E9GAC8"/>
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    <dbReference type="GO" id="GO:0020037">
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        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="GO" id="GO:0005344">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Globin/Proto"/>
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        <property type="entry name" value="Mb-like_M"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
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            <end position="22"/>
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    </feature>
    <feature type="chain" id="PRO_5003240165" description="GLOBIN domain-containing protein" evidence="7">
        <location>
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        </location>
    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX83724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="196" mass="22197" checksum="F0B4041CABEAC910" modified="2011-04-05" version="1">MLVHYILTAILVVFLETRPGRAECPRGYKASSSGQRDPSTKSESQRILENFLNERDEATIRSTWNTAKKNGNIGPKTFLRYFELKPEAQKMFPAFAEVDHMKLPTNEDFLAQAQNCVSGLNSYVEHLGKNPKNCPFIAKAKGKYHHEDLKLLGVTLMGVLEEELGKGFTDETKEAWKKGLRAMNEAVTKRPNPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAL1</accession>
    <name>E9GAL1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_315717</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83265"/>
    <dbReference type="EnsemblMetazoa" id="EFX83265">
        <property type="protein sequence ID" value="EFX83265"/>
        <property type="gene ID" value="DAPPUDRAFT_315717"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315717"/>
    <dbReference type="eggNOG" id="KOG2776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041451_2_1_1"/>
    <dbReference type="InParanoid" id="E9GAL1"/>
    <dbReference type="OMA" id="FKCSAVE"/>
    <dbReference type="OrthoDB" id="834026at2759"/>
    <dbReference type="PhylomeDB" id="E9GAL1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004545">
        <property type="entry name" value="PA2G4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00495">
        <property type="entry name" value="crvDNA_42K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX83265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="394" mass="43311" checksum="A36D20AA4A53F645" modified="2011-04-05" version="1">MAEKDKQEKTIAEDFVVTKYKMAGDISNRVIQGVIAQCVAGASVQKLCTLGDGLLLEETVKVLEKEKDMKKGVAFPTCLSVNNCVFYFSPLASDTDVELKDGDVVKIELGAHVDGFIASVAHTVVVGSSPSTKIAGRKADILLAAHYASEAALRLMKPGTETQAITSVVQTIAESFKCNPIQGRLSHQLKQFEIKGEKSIILNPNDIQLKEHEESTLELHEVYAIDVVISSGEGVVQKMDTRTTVFKKTNETYVLKKKASHALLEEVNSKCGTMPFSLRNLEDEKKACMGVPECVSHKLLEPFPVIFEKPNEIVAQFKFTVLLMPNGPQKITGLPFDPTAFQTENIITDEKVKKLITSSTCSKPNKKKKKPATTEVEKVSPSEHLFNSVLIAMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBZ0</accession>
    <name>E9GBZ0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_240615</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732538">
        <property type="protein sequence ID" value="EFX83070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83070"/>
    <dbReference type="EnsemblMetazoa" id="EFX83070">
        <property type="protein sequence ID" value="EFX83070"/>
        <property type="gene ID" value="DAPPUDRAFT_240615"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_240615"/>
    <dbReference type="eggNOG" id="KOG1428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700695_0_0_1"/>
    <dbReference type="OrthoDB" id="215263at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008582">
        <property type="term" value="P:regulation of synaptic assembly at neuromuscular junction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005345706" evidence="1">
        <location>
            <begin position="22"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="394" mass="43903" checksum="116F217DC9F286D1" modified="2011-04-05" version="1">MNRRHWPFFKLEFRLMALDLAQHYGTSNVNGIVGLVLALSGSRVGRTFISQQSTLPANLLSLLHTGSPRIQRQVTALLRRMLSELPPPVFASLVGVDVLPTTDYGILQVLNSTGSIERVGFLDVVLACIAKALTIQDVLKTSSKNPILSVTMASIFNNRQQPQRQLGSRWWMRGHMPLRIAKSIIQLIRDMVSGNLSEVWSAVTKAVLALTKLDDEDRRSSLDCLQTPSVWLTLAALCLLQDEHVERLSSTQWARGAVNKPQCNNDVDGETGAQIVCSDCGPLCIDCDRVLHLSRKFRSHQRQVCKEEEEVIKVDVHEECGRVKLFWILALSDARNLKSLVEFPSLPSTSLPLRTKAYHVDHQRSLTLATGDARAFSSRPSLRQSPSPCALVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDN6</accession>
    <name>E9GDN6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_241199</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82113">
        <property type="protein sequence ID" value="EFX82113"/>
        <property type="gene ID" value="DAPPUDRAFT_241199"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241199"/>
    <dbReference type="HOGENOM" id="CLU_1449096_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GDN6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241110" evidence="3">
        <location>
            <begin position="23"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX82113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="187" mass="21828" checksum="B0C1D086A986F454" modified="2011-04-05" version="1">MKYGIITIVGCLLFLMVISANGHRHTKFSIRTEMTTFTRTVLTTTVCVILAVDPMPVCRRRRRQLWMEQEPELFWIPEEQFFIQPTHMLQVEPTELPSPWFRDDDDQQDFPFDANVRLFNMAHHDIQPSLLTSLSQHQRKIPFNSSNNGIKNPLTQTANSDTRKVELQQSPLPNRRPRSKCRPKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDP6</accession>
    <name>E9GDP6_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_101537</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82439">
        <property type="protein sequence ID" value="EFX82439"/>
        <property type="gene ID" value="DAPPUDRAFT_101537"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_101537"/>
    <dbReference type="HOGENOM" id="CLU_944169_0_0_1"/>
    <dbReference type="OMA" id="WDSRTAG"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240236" evidence="2">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX82439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="281" mass="28019" checksum="CD82F0457B1BEA3D" modified="2011-04-05" version="1">MKSNLSLLLVALVCFTAIQAAPHSLNKRQAVAAAAPAAAPAAAAPAAKVVGEAEPVEEAEPVEVEEVEPVEGAPAAPAPVKAAPDAPAKTEAKPVVEEEPVEAEPVETEPVEAEPAEAEAEAEAAEAEPAEAEAGAARRKRQTVTAEASAGTSATAGTMIPFEPPKDTLEVTQAKAAHFAAHAQVKAAQLAAVAPAAAPVAAPAAAPAVVAGEEVEPVEQEPIEEVEPAEAAEQAEVEAAEPAEAAEAAEAAEAEAAEAAEVEAAEAGGAARRKRNSPMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDS1</accession>
    <name>E9GDS1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4789 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_316713</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82134">
        <property type="protein sequence ID" value="EFX82134"/>
        <property type="gene ID" value="DAPPUDRAFT_316713"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_316713"/>
    <dbReference type="HOGENOM" id="CLU_940926_0_0_1"/>
    <dbReference type="InParanoid" id="E9GDS1"/>
    <dbReference type="OrthoDB" id="1574404at2759"/>
    <dbReference type="PhylomeDB" id="E9GDS1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031993">
        <property type="entry name" value="DUF4789"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16033">
        <property type="entry name" value="DUF4789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4789" evidence="2">
        <location>
            <begin position="97"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX82134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="296" mass="32691" checksum="0003292914EB76F8" modified="2011-04-05" version="1">MDTDIENNDHYDIRYALVDLETRVRPRVARLSRDIDATLINPDQKAGEHKFQKGLLEDITRILYKAGARACLSPHETFHLPSKKCLKFGANAKVNPCADKKDQVLYDGKNNEGTCDCVEDERHLVYYDGECYQQNFQGPCSPNFWLVMINGTISCEAIPANCVADGQHIYWSPNPETVPAECHHIGKRGPCSIDQVVSRDATGAVSCVVSKEPIKAVAAKIAKTAARNNTATRNARLNSGATTTIAPEPEAEVAPQKKKDTKKPVTPVELNPSSMWDQQSCSLGSYRKQTGKCPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9GE28</accession>
    <name>E9GE28_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_241363</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX82386"/>
    <dbReference type="EnsemblMetazoa" id="EFX82386">
        <property type="protein sequence ID" value="EFX82386"/>
        <property type="gene ID" value="DAPPUDRAFT_241363"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241363"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="E9GE28"/>
    <dbReference type="OMA" id="NISSMWG"/>
    <dbReference type="OrthoDB" id="1194344at2759"/>
    <dbReference type="PhylomeDB" id="E9GE28"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX82386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="286" mass="30803" checksum="1E9CF43B47EB9842" modified="2011-04-05" version="1">MLKTTSLLSRRFLLSSQDVRQIGTAAEVARQRRSLQGRVAVVTASTDGIGFAMAQRLAVDGAHVVISSRNQKNVDEALAKLKSEGLSVSGMVCHAGVKEDRTRLLEKTAAEFGGFDILISNAAVNPDSGRLMKCTEEVWDKIFDVNVKSSFFLAKEALPHMEKRGKASIMFVSSVGGYLPNCAVDFMGAYALSKTALLGLTKLMAMELGPRGIRVNCICPGLIETRFGDVITGDKRTPKIMRDNCPMQRNGRPEEMAGLASFLASDDSSYITGENIVAAGGIQSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEC7</accession>
    <name>E9GEC7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_302643</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX82239"/>
    <dbReference type="EnsemblMetazoa" id="EFX82239">
        <property type="protein sequence ID" value="EFX82239"/>
        <property type="gene ID" value="DAPPUDRAFT_302643"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302643"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033941_0_0_1"/>
    <dbReference type="InParanoid" id="E9GEC7"/>
    <dbReference type="OrthoDB" id="1337075at2759"/>
    <dbReference type="PhylomeDB" id="E9GEC7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX82239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="561" mass="62819" checksum="96A31CB91B773FA4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEE8</accession>
    <name>E9GEE8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_316936</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82254">
        <property type="protein sequence ID" value="EFX82254"/>
        <property type="gene ID" value="DAPPUDRAFT_316936"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_316936"/>
    <dbReference type="HOGENOM" id="CLU_095093_0_0_1"/>
    <dbReference type="InParanoid" id="E9GEE8"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="PhylomeDB" id="E9GEE8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX82254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="230" mass="25727" checksum="03B7B27FBA80FF95" modified="2011-04-05" version="1">MTEFKKYFLEMKLNGHDIGEPDLVSNGDTRSSATGVIPLKGGFLAKMNFAGIDFECPVQVSDDDNTRNLIGRRALPFLVDFDWNKFVSDGTNAMVSDWTPDNIKKQQLMDDALNLISKRFHVKVSVDHKHFGMILDTGATCSIAGLAKWKELGEPHINPVNRSVESTSNQFIPILGECSLNIKYNGTEAQLPLLIADSDEIPAILDQIQFLIPHFKRAKNEQEHEAQLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEQ4</accession>
    <name>E9GEQ4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_35405</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732541">
        <property type="protein sequence ID" value="EFX82039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX82039"/>
    <dbReference type="EnsemblMetazoa" id="EFX82039">
        <property type="protein sequence ID" value="EFX82039"/>
        <property type="gene ID" value="DAPPUDRAFT_35405"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_35405"/>
    <dbReference type="eggNOG" id="KOG0527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082854_5_1_1"/>
    <dbReference type="InParanoid" id="E9GEQ4"/>
    <dbReference type="OMA" id="MEQETFI"/>
    <dbReference type="OrthoDB" id="626731at2759"/>
    <dbReference type="PhylomeDB" id="E9GEQ4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="SSF47095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="2">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX82039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="81" mass="9962" checksum="2860A5F208BB916D" modified="2011-04-05" version="1" fragment="single">KAREQRVRRPMNAFMVWAKVERKRLADENPDLHNADLSKMLGKKWKGLTPQDRRPYVEEAERLRVIHLQEHPNYKYRPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9GES1</accession>
    <name>E9GES1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">XPGN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_49689</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732541">
        <property type="protein sequence ID" value="EFX81885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81885"/>
    <dbReference type="EnsemblMetazoa" id="EFX81885">
        <property type="protein sequence ID" value="EFX81885"/>
        <property type="gene ID" value="DAPPUDRAFT_49689"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_49689"/>
    <dbReference type="eggNOG" id="KOG2520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1194561_0_0_1"/>
    <dbReference type="InParanoid" id="E9GES1"/>
    <dbReference type="OMA" id="RRTLYHK"/>
    <dbReference type="OrthoDB" id="1094524at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPGN" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX81885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="257" mass="28728" checksum="F8CF3A55F18ACD20" modified="2011-04-05" version="1">MGVHGLWNLLEPVGKPVPLETLENKVLAVDVSIWLHQATKGFRDAQGNPLPNAHLLGLCHRLCKLLFFKIKPVFVFDGGVPVLKRQTMAARHNRRDTAVKNNDMVAEKILSNYIKSEVINKQLGKNKGKSGAPLLKKKKLEPDLFELPPIPNQNTEEVSSESDFDDDANGNLGAISLHMKGHNIHSVDVTSEAFLALPTEIQHEILLELRDTRKQSSWNRIHQMPQVILVACFLLLILFLGERGDHNSRGLLLTSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9GFW2</accession>
    <name>E9GFW2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphatase and tensin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_49762</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732542">
        <property type="protein sequence ID" value="EFX81708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81708"/>
    <dbReference type="EnsemblMetazoa" id="EFX81708">
        <property type="protein sequence ID" value="EFX81708"/>
        <property type="gene ID" value="DAPPUDRAFT_49762"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_49762"/>
    <dbReference type="eggNOG" id="KOG2283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020105_5_0_1"/>
    <dbReference type="InParanoid" id="E9GFW2"/>
    <dbReference type="OMA" id="ENSIRIC"/>
    <dbReference type="OrthoDB" id="639380at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014065">
        <property type="term" value="P:phosphatidylinositol 3-kinase signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of protein kinase B signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd14509">
        <property type="entry name" value="PTP_PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045101">
        <property type="entry name" value="PTP_PTEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="SSF49562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="5">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="7">
        <location>
            <begin position="191"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX81708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="280" mass="32463" checksum="023A1110673E6500" modified="2011-04-05" version="1" fragment="single">MASTIKGLVSRKKKRYKEDGFNLDLTYIFDNVIAMGYPAAKLEGVYRNHIDDVYKFLETKHKDHYKIYNLCSERSYDYSRFNNRVSSFPFDDHNPPKLGLIEPFCKDMDEWLNQDQSNVAAIHCKAGKGRTGLMICCYILHRGWAENADDALKHYGQTRTHDTKGVTIPSQRRYVEYYDQLLKEGGSGYSLCPLELREIRLQPIPNMSGGCVPVLTIFEAESQQEFNPPIELTKVGRVLRITLKTPLSLKGDVRVILKNKPNVIMLKEKMFHFWFNTYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9GGD9</accession>
    <name>E9GGD9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_230846</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732543">
        <property type="protein sequence ID" value="EFX81386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX81386"/>
    <dbReference type="EnsemblMetazoa" id="EFX81386">
        <property type="protein sequence ID" value="EFX81386"/>
        <property type="gene ID" value="DAPPUDRAFT_230846"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230846"/>
    <dbReference type="eggNOG" id="KOG0077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_6_0_1"/>
    <dbReference type="InParanoid" id="E9GGD9"/>
    <dbReference type="OMA" id="DDRIAQH"/>
    <dbReference type="OrthoDB" id="1168548at2759"/>
    <dbReference type="PhylomeDB" id="E9GGD9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="PTHR45684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX81386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="192" mass="21803" checksum="CD302ACFDD983FE9" modified="2011-04-05" version="1">MFVWDWFTGVLGMLGLWKKSGKLLFLGLDNAGKTTLLHMLKDDRMAQHVPTLHPTSEELSIGNMRFTTFDLGGHTQARRVWKDYFPAVDAIVFLVDAFDTQRFPESKTELCSLLADEQLGHCPILILGNKIDRSGAASEDQLRSYFELHNTTGKGKTPRSELSSRPLELFMCSVLKRQGYGEGFRWLAQYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIT5</accession>
    <name>E9GIT5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_196790</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80321"/>
    <dbReference type="EnsemblMetazoa" id="EFX80321">
        <property type="protein sequence ID" value="EFX80321"/>
        <property type="gene ID" value="DAPPUDRAFT_196790"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_196790"/>
    <dbReference type="eggNOG" id="KOG1437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415780_0_0_1"/>
    <dbReference type="InParanoid" id="E9GIT5"/>
    <dbReference type="OMA" id="YSLDPWQ"/>
    <dbReference type="OrthoDB" id="926852at2759"/>
    <dbReference type="PhylomeDB" id="E9GIT5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240382" evidence="1">
        <location>
            <begin position="23"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="30"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="174"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="338"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="486"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX80321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="677" mass="75915" checksum="AF312ABE50B47BF7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJG7</accession>
    <name>E9GJG7_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_304136</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="509" mass="58335" checksum="4CDBC15C7EE65315" modified="2011-04-05" version="1">MPQPKWYNKSLSAMCMDSIVDNMEKWTALRSSVHVSILFYLLPSHCLEYMTLEWVKRNHCWVITKEMFELLLNPHSKVLDLSKWNMHITDRLRIVRLASVRCSQLTTLKMGFLNKLQSNQVEDTFTPMLQLFEHLQILDLSGTIYGASCMINLGLTDKPKLRELQVNSCPGVTDSVMQVFCNGQSSLQKLSVRGTEVTLIGIRFAIEHLPELKEINCKDESDILQIFRGIRNDDRESKKYSLAELIMLNRMWNVPDKVPYEKGSVSLMVDMCPSLVDVFIHVDDEGFTNEELLGFRQLQQLKNLKIDKWSSISIRGGVIPLLQARGHTLERLFLSIQVTSEEVFLIIESCPNIRCLLLILEGTDLGTPEPVVDDCVHSSLCSPKEVFPLRMLEEISLFTYFSPFAISRKLLLLLLSSLTITDIFINECFTLDDKIIEEACAKNSFKYLTRLWLCGCSNVSQKGIDFFLNEANPLDEIALKDCGNVNLEHMKTMAQEKHWNSVKITVEDY</sequence>
</entry>
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    <name>E9GMN7_DAPPU</name>
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        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Liu Z."/>
                <person name="Zhang W."/>
                <person name="Zhao Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="GL732553">
        <property type="protein sequence ID" value="EFX79261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MN730099">
        <property type="protein sequence ID" value="QNM80593.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79261"/>
    <dbReference type="EnsemblMetazoa" id="EFX79261">
        <property type="protein sequence ID" value="EFX79261"/>
        <property type="gene ID" value="DAPPUDRAFT_225189"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_225189"/>
    <dbReference type="HOGENOM" id="CLU_142456_0_0_1"/>
    <dbReference type="OrthoDB" id="1231780at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX79261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QNM80593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="156" mass="17735" checksum="869F0E87AA2E90EB" modified="2011-04-05" version="1">MELNPPPWNTVDIIVHSQGVIDVLLDNHDFSMSFFDGKEKITVDQMPLFSPISYDVKKRLIWIKFSAIRMPIDLYYISRSPPCIQGGTALYRAVMMTAYLAGFGPQSEAAEPDEPRIFMTINPQHNVPTIVDDGFFLTRARPFRLISLTDTVARIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9GMQ4</accession>
    <name>E9GMQ4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732553">
        <property type="protein sequence ID" value="EFX79137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79137"/>
    <dbReference type="EnsemblMetazoa" id="EFX79137">
        <property type="protein sequence ID" value="EFX79137"/>
        <property type="gene ID" value="DAPPUDRAFT_245167"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_245167"/>
    <dbReference type="eggNOG" id="ENOG502QSFR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037252_1_0_1"/>
    <dbReference type="InParanoid" id="E9GMQ4"/>
    <dbReference type="OMA" id="ASEHICI"/>
    <dbReference type="OrthoDB" id="1481068at2759"/>
    <dbReference type="PhylomeDB" id="E9GMQ4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GTPase-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GTPase_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042507">
        <property type="entry name" value="TBC1D19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16110">
        <property type="entry name" value="PTHR16110"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="SSF47923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="187"/>
            <end position="437"/>
        </location>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Wolf Y.I."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="176" mass="19621" checksum="AFA42BB292CF0C89" modified="2011-04-05" version="1">MLYQQTGGSEFSTPIGTASETTGGLMHNHLTLIWDKTYTQTSDPKASVLETGIAALKYIGIPGKYRLTDEDNELVFHLVLNPRCIPTHQQCARKTRAFDVIGQPDIYVVTVPVKPTNISLKEIHKHTPEIDKVDITANLQYMRDKIIDHENELAHAIASFQCDSRKAAHERAILAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="4">Belongs to the OSBP family.</text>
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    </dbReference>
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    <dbReference type="OrthoDB" id="949920at2759"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="890"/>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX78755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9GRM0</accession>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="6">
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        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Daphniidae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
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                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
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                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732562">
        <property type="protein sequence ID" value="EFX77415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77415">
        <property type="protein sequence ID" value="EFX77415"/>
        <property type="gene ID" value="DAPPUDRAFT_305754"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305754"/>
    <dbReference type="HOGENOM" id="CLU_1769946_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX77415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="147" mass="16780" checksum="E5A8DAEFB2B4ABA9" modified="2011-04-05" version="1">MSQKLIRSMHHSNVICVPSDVTHQHFGNKAKEGYLKVKSGVTYSSERNDGQNEASIVLDWTNERTIQIVSGRRAEYRDPRRIPPQKTFHGASKRTFPSLFYSCRYADTLAHIEERSLNLFLKCKGGNSGKIRTGNKTFLGKFLNSCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GT14</accession>
    <name>E9GT14_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_106242</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732563">
        <property type="protein sequence ID" value="EFX77353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77353">
        <property type="protein sequence ID" value="EFX77353"/>
        <property type="gene ID" value="DAPPUDRAFT_106242"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_106242"/>
    <dbReference type="HOGENOM" id="CLU_1205831_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX77353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="230" mass="26450" checksum="86FF27E40D2EB44B" modified="2011-04-05" version="1">MLRENQNSSTEKGTVILELLLLKPKLEQTKLGKEKRGIKIHQSREHKDKEWKIYYSSMVPLGTEGHLTDRVSGSMMERVAEDCSSRHTLPVIVNEDTLWQPTPMIDEDHHPLTWWKETGVGERKGRRVYNSHGYVYAFKYERKTDSSQVFRCRSVDGTGKECLSRVILASNSYTPSNDHTCIVKPAPNIYERDVIVRKAKAVGLKFKAVSLSNILRPLLENYAHENVILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTY3</accession>
    <name>E9GTY3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="4 6">6.3.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_198635</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + diphthine-[translation elongation factor 2] + NH4(+) = AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the Diphthine--ammonia ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="4 6"/>
    <dbReference type="EMBL" id="GL732565">
        <property type="protein sequence ID" value="EFX76937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76937"/>
    <dbReference type="EnsemblMetazoa" id="EFX76937">
        <property type="protein sequence ID" value="EFX76937"/>
        <property type="gene ID" value="DAPPUDRAFT_198635"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_198635"/>
    <dbReference type="eggNOG" id="KOG2316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010289_0_0_1"/>
    <dbReference type="InParanoid" id="E9GTY3"/>
    <dbReference type="OMA" id="NYALYWA"/>
    <dbReference type="OrthoDB" id="707303at2759"/>
    <dbReference type="PhylomeDB" id="E9GTY3"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="Alpha_ANH_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="PTHR12196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039123">
        <property type="entry name" value="Diphthamide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthami_syn_2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX76937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="258" mass="28695" checksum="1A43E3B014F780C5" modified="2011-04-05" version="1">MRTVALISGGKDSCYNILQCIAAGHEIVALANLHPPISSNESNFFTLDEMDSYMYQTVGHDAIDLYSEATGLPLYREAIIGTSLQQGSDYTHESPEDEVEDLYRLLSHVKEMESIEAVSVGAILSNYQRVRVENVCNRLGLTSLSYLWQRDQEELLNEMILSGMNSILIKVAALGLDPKKHLGKSLQECQHDLLKLKAKFGLNVCGEGGEYETLTLDCPLFKKSIVVIESETVPHSKDPFAPVAYLKFPKLSLAHKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GU04</accession>
    <name>E9GU04_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_248252</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
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                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
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    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <name>Mg(2+)</name>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006378">
        <property type="term" value="P:mRNA polyadenylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045100">
        <property type="entry name" value="TUTase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19088">
        <property type="entry name" value="TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TUTase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="5">
        <location>
            <begin position="169"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX76405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="258" mass="30184" checksum="CD771BC27B9BE686" modified="2011-04-05" version="1">MDLCLVISGHDVDQRFHALEYLYRVQKALKQCRFLTKLDVIRAKVPILRFYDSITNLEVDLNFNNIVGIRNTHLLKTYAQLDWRVRPLVLAVKLWARQHDINEAKSMTMSSYSLTLMVIYYLQTGVHVPVLPCLQKVRAERFWPEGDIRRLQTFTDEELKVLRSNNHMTLGQLFAGFLDYYAHHFKLGGTIPLEQCRQYMSPKNDPHHWKYICIEEPFDRTNTARSVYDPAAFQKIVDVFRQSAAKISQSKDLSSVMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9GVW8</accession>
    <name>E9GVW8_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_55387</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732569">
        <property type="protein sequence ID" value="EFX76378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_55387"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1437819_0_0_1"/>
    <dbReference type="OMA" id="QGHIGEP"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="189" mass="17274" checksum="19E1A126F5043066" modified="2011-04-05" version="1" fragment="single">GPPGPPGPQGSPGSAGSSGGSAYGGSSYTQPQVIPGPPGPPGPPGPAGYKGDAGAPGAPGYPGGPGPQGPAGKPGSPGYPGEKGASGYNGAPGAPGKPGYNGEKGTPGGPGPAGPLGPVGPVGPQGKPGSPGYPGPAGPAGPAGSPGQTYEAPAPAYPAPAYPVPAPAYPAPAPIYQQPIYEPPAPSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GWN7</accession>
    <name>E9GWN7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_249440</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX76145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX76145"/>
        <property type="gene ID" value="DAPPUDRAFT_249440"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_249440"/>
    <dbReference type="HOGENOM" id="CLU_2981179_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="58" mass="6376" checksum="8A6227B0688E30FB" modified="2011-04-05" version="1">MEAPMIDSFMKQRVGRSSDQRSKPQHPTDAKNAKNYVTWNASALTDGNAQTVAPPTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9GWT3</accession>
    <name>E9GWT3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_107339</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732571">
        <property type="protein sequence ID" value="EFX75958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75958">
        <property type="protein sequence ID" value="EFX75958"/>
        <property type="gene ID" value="DAPPUDRAFT_107339"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_107339"/>
    <dbReference type="HOGENOM" id="CLU_060417_0_0_1"/>
    <dbReference type="OrthoDB" id="520602at33208"/>
    <dbReference type="PhylomeDB" id="E9GWT3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="319" mass="37081" checksum="B245559DA4EF4C09" modified="2011-04-05" version="1">MNYDAVSRLIRPGLRELLKNMFQVRKGTIFYLIMMEYATTSFLDKQMAPLERIFFLWFAVFSVRYWRYWMMCDQAYPLAKHFFTSNAYQCLELNAHSLVPTELRLQESQMTELFLPWCFSSQQCESYYKALRSFTPVGSTQTNFTIGEVITGWTADGRVDANLIATAEGDVHGIIYPRHIAQIERREHPSKNQIVATIKRALQEAKSELNQSRVLVNTADRECFKYDPRLAVTSTSSELEKIASPLVDDCDEPDIERVDEIDDQLDERDRQDIEMLNLLFDAEFMDFTNHLSACKIKNKTLYLLSVPLELTPFVKTLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9H014</accession>
    <name>E9H014_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_56547</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732579">
        <property type="protein sequence ID" value="EFX74965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74965"/>
    <dbReference type="MEROPS" id="S01.151"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_56547"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_7_0_1"/>
    <dbReference type="InParanoid" id="E9H014"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="PhylomeDB" id="E9H014"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="215" mass="21864" checksum="2F84463424BE81DD" modified="2011-04-05" version="1" fragment="single">LVGGTAAAPGEFPFQAALNLNGGLCGGTLISESIILTAAHCLSGVTANTLSLRGGANAVTRRVRKFVVHGSYNSKTNDNDIALLALSSPIKNVAFVKLPSASASTYAGNSAVIAGWGTTSSGGRISQTLLKATVTVLENAACNKKYGGKITSNMICAAAPGKDTCQGDSGDPLLVGGVQGGITSFGYGCADSKFPGVYTRVSNYVDWIKRTLANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9H063</accession>
    <name>E9H063_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_108429</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732579">
        <property type="protein sequence ID" value="EFX74937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74937">
        <property type="protein sequence ID" value="EFX74937"/>
        <property type="gene ID" value="DAPPUDRAFT_108429"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_108429"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050286_0_0_1"/>
    <dbReference type="InParanoid" id="E9H063"/>
    <dbReference type="OrthoDB" id="1636325at2759"/>
    <dbReference type="PhylomeDB" id="E9H063"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="358" mass="39778" checksum="15960383D0ED8801" modified="2011-04-05" version="1">MSDQQKRSSRYPTCGRAPSRRLHPELFPSSQPPPIQDEETVTGHTVALPQPRPSSPLSAALDDDVSPSIQLDSDEESSVTSSADSENEFSIVRVPVLLPLRILPLAPMAVSVQKFIAPPVFSASPEEDTVDWLERFELAATYNRWSDADHARNFVMYLEGAARKWFLVHTHPNHWEDLPVRPNPADPTLPNLPAAIGLKSQFSAAFRQTNFSLIQESKLRQREQGNEEDVVAYFYDIINLCRIVNPTMSQEQQLQYLYRGLKPTLLQTIYPFQPASTTDFLELAKLHAEASSLVNRKILSQSLLAVAPDVSHPSTVSSTNLVNELAKLITGLQQTIQQLHRPPTAVPPQGHNSSGAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0P7</accession>
    <name>E9H0P7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_324102</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732581">
        <property type="protein sequence ID" value="EFX74714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74714">
        <property type="protein sequence ID" value="EFX74714"/>
        <property type="gene ID" value="DAPPUDRAFT_324102"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_324102"/>
    <dbReference type="HOGENOM" id="CLU_2239287_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX74714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="105" mass="11884" checksum="A013C5A9DD3B70AE" modified="2011-04-05" version="1">MELHLEQLAAAACLLSIPIEAGFNRFEREYGLSSAQDFNPCKGYIACNRSDSPSYPFAYLSYPIHCQESVPEDPLIPYHHHVHAMAINFLPKISVLQKCVKTILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9H390</accession>
    <name>E9H390_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_57907</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732588">
        <property type="protein sequence ID" value="EFX73717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX73717"/>
    <dbReference type="MEROPS" id="M16.005"/>
    <dbReference type="EnsemblMetazoa" id="EFX73717">
        <property type="protein sequence ID" value="EFX73717"/>
        <property type="gene ID" value="DAPPUDRAFT_57907"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_57907"/>
    <dbReference type="eggNOG" id="KOG0959">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004639_1_0_1"/>
    <dbReference type="InParanoid" id="E9H390"/>
    <dbReference type="OMA" id="INQVMEH"/>
    <dbReference type="OrthoDB" id="1008844at2759"/>
    <dbReference type="PhylomeDB" id="E9H390"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="7">
        <location>
            <begin position="114"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="8">
        <location>
            <begin position="273"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_M" evidence="9">
        <location>
            <begin position="463"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="8">
        <location>
            <begin position="755"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX73717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="975" mass="111071" checksum="5FAADBBDD34B5488" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9H4K5</accession>
    <name>E9H4K5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">EOG090X03VW</name>
        <name evidence="9" type="synonym">SRP54</name>
        <name evidence="11" type="ORF">DAPPUDRAFT_325390</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">PA42</strain>
            <strain evidence="13">TCO</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Signal recognition particle consists of a 7S RNA molecule and at least six protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732592">
        <property type="protein sequence ID" value="EFX73155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR014559">
        <property type="protein sequence ID" value="SVE84178.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015172">
        <property type="protein sequence ID" value="SVE84791.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX73155"/>
    <dbReference type="EnsemblMetazoa" id="EFX73155">
        <property type="protein sequence ID" value="EFX73155"/>
        <property type="gene ID" value="DAPPUDRAFT_325390"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_325390"/>
    <dbReference type="eggNOG" id="KOG0780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_1_1"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="OrthoDB" id="463152at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="10">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX73155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="SVE84178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="SVE84791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="506" mass="55521" checksum="68D145FA87EBA9DC" modified="2011-04-05" version="1">MVLADLGRKITSALRSLSNATVINEEVLNAMLKEICAALLESDVNIRLVKQLRENVKSVIDFDDMAGGLNKRRMIQSAVFKELIKLVDPGVKPYQPVKGRPNVIMFVGLQGSGKTTTCTKLAYHYMKKGWKSCLVCADTFRAGAYDQLKQNATKARIPFYGSYTEVDPVVIAQEGVDMFKAENFEFIVVDTSGRHKQEDSLFEEMLQVSNAVKPDNIIFVMDASIGQACEAQARAFKEKVDVGSVIITKLDGHAKGGGALSAVAATQSPVIFIGTGEHIDDLESFKTKPFISKLLGLGDIEGLIDKVNELKLDDNEELIEKIKHGQFTLRDMYEQFTNIMKMGPFSQIMGMIPGFSQDFMTKGGEQESMARLKKLMTIMDSMNDSELDHQDGAKLFSKQPTRMARVARGSGVTEREVKELISQYTKFAAVVKKMGGIKGLFKGGDMTKNVNPTQMAKLNQQMARMMDPSVLQRMGGMGGLQNMMRQLQQGAGGLGNLMGMGGGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5C0</accession>
    <name>E9H5C0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_110133</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732593">
        <property type="protein sequence ID" value="EFX73106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73106">
        <property type="protein sequence ID" value="EFX73106"/>
        <property type="gene ID" value="DAPPUDRAFT_110133"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_110133"/>
    <dbReference type="HOGENOM" id="CLU_2266381_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9H5C0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX73106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="123" mass="12758" checksum="F25D5A166B23826A" modified="2011-04-05" version="1">MVMSKTQIRAARTCRGHTELHVIVRTAFLAAARATSFMAQVGVIPSHGWGSNRNQLLSIAAPLIQNIRGRRGPRGEGRGRGNHGGVIARGRGAPGRGAPGRGAPGRGAHGRGARGRGAHGHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9H621</accession>
    <name>E9H621_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_308045</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732595">
        <property type="protein sequence ID" value="EFX72823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72823"/>
    <dbReference type="EnsemblMetazoa" id="EFX72823">
        <property type="protein sequence ID" value="EFX72823"/>
        <property type="gene ID" value="DAPPUDRAFT_308045"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_308045"/>
    <dbReference type="eggNOG" id="KOG0716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_14_0_1"/>
    <dbReference type="InParanoid" id="E9H621"/>
    <dbReference type="OMA" id="DINHAHR"/>
    <dbReference type="OrthoDB" id="1401920at2759"/>
    <dbReference type="PhylomeDB" id="E9H621"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061177">
        <property type="term" value="C:type Is terminal bouton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900073">
        <property type="term" value="P:regulation of neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX72823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="244" mass="26908" checksum="0DFFFE981FD690CE" modified="2011-04-05" version="1">MDKRRYSTTGDSLYICMDLTKQATSDDIKKAYRRLALRYHPDKNPSPEAAEKFKEVNHANSILSDSTKRNIYDNYGSLGLYIAEQFGEENVNTYFLVTSGWCKALFIGCGIITGCYFCCCCCCCFNFCCGKCKPKAPDETGDYHNFQDGHQEGAAASQQPIIVEQPRSQKENDDSSDEDEAEEVRSAAREAISVQPESRNVTETTGLNPSDKPPTYAAATSQSGTPQHGSTAKAAIPIQSHHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6U3</accession>
    <name>E9H6U3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="3">SDH assembly factor 3</shortName>
            <shortName evidence="3">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_200992</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732598">
        <property type="protein sequence ID" value="EFX72572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72572"/>
    <dbReference type="EnsemblMetazoa" id="EFX72572">
        <property type="protein sequence ID" value="EFX72572"/>
        <property type="gene ID" value="DAPPUDRAFT_200992"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_200992"/>
    <dbReference type="eggNOG" id="KOG4100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102310_2_0_1"/>
    <dbReference type="InParanoid" id="E9H6U3"/>
    <dbReference type="OMA" id="LTEWQMY"/>
    <dbReference type="OrthoDB" id="1613308at2759"/>
    <dbReference type="PhylomeDB" id="E9H6U3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
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        </source>
    </evidence>
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        </source>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Shapiro H."/>
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                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX71983.1"/>
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    </dbReference>
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            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX71983.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="374" mass="42214" checksum="3AE8D60C65F4CEEC" modified="2011-04-05" version="1">MTLASTNAKAKSNARVTATKNPPPVIENAAQGSKRDSAATATGTQARVTNSKTAVKNADVLRTTHHRREFSNDGRKQHYRMRLRTRYTTRRGYFFGSFDTIDTMVTSVTTVDECRQLVKSHVCDGNKMTKLNENAYEFKGNPTQKGTWMQEGLQTQNNTTCLESTNKGTNAWCLLFGGLQRQTSRGGKLLTNKDKPAVDIERRKTSGKTEEIGPLLAQHHQYIEDKTLGREIALLKEIKEIYCGNLQLRKYTTQLLAENNGLQAAMANNLPICSRLKPNGVHLIIQQCEAKNVTIRGQKTKCGFEPRFNNYTVGRDGYSLHPFQECFWKDQIINLNGHSYSWNSTSENYTRVYLTYHLATTTYNKSSQISMTTS</sequence>
</entry>
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    <name>E9H8J4_DAPPU</name>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EFX71936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX71936">
        <property type="protein sequence ID" value="EFX71936"/>
        <property type="gene ID" value="DAPPUDRAFT_59685"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9H8J4"/>
    <dbReference type="OMA" id="WVMQPIY"/>
    <dbReference type="OrthoDB" id="941048at2759"/>
    <dbReference type="PhylomeDB" id="E9H8J4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="85"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX71936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="414" mass="45586" checksum="283EA19E0F5A3706" modified="2011-04-05" version="1">MASDDEILPILENEVPGDVKEEESETINESSAPSHPNEVGDDDTDVEIQLSGCGASPFCDPRRMPHRFIALFLMCLLGFGSTFCYDNPGALQDNIKSDMGINTAQFANLYAWYSWPNVILCFIGGFLLDRVFGMQLGTIIFATLVLLGQLTFALGGILNKFWLMEMGRLIFGIGGESLAVAQNTYAVSWFKGKELNMVFGLQLSFARLGSTVNFNVMGPLYKHVSQFYTGYLCTGVVLMIASASCVMSLLSGLILGYLDKRANRILKKTGQAGEVIRFSDVKDFPATFWLMSVICVAYYVAIFPFIGLGQVFFERKFDFSPRNANAVNSIVYVISAVASPFFGILVDKVGRNILWVFLAIVFTIGSHALLTFTFVNPYVGMVTMGFSYSMLASALWPMVALVVPEYQLGTAYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9H966</accession>
    <name>E9H966_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Rogozin I.B."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732607">
        <property type="protein sequence ID" value="EFX71741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX71741">
        <property type="protein sequence ID" value="EFX71741"/>
        <property type="gene ID" value="DAPPUDRAFT_111443"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_111443"/>
    <dbReference type="HOGENOM" id="CLU_746535_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="371" mass="42423" checksum="AFD74D265122A5A8" modified="2011-04-05" version="1">MGMKIRANSQAVVSNKRICRETSHPSSRVADLWKIRIQTAKSLPQQELVDREILMELGLSSSPTYGFSSDIIHSPDHFEEVHDLILSDPGWDDNLGPTHPSLNQIYRKRILDPSMTEEYRRKIDVLSSIQSRVVAVEEIAPQMIDGVLQSENAYDVTKTKEDFAMEIEITRDPVQSQRSREWRGWWPAGSSVRRVTKYEDCLSGQSGRFKEDSVKEDSVKEDSVKEDSVKETTSKKTQHTSATTTPKKSALKQKLNNGNAAVPEDDDAQKLDEESRRKWIRRSSESSSSSDDQLQVKRKKSLQRLKEAKRFKKLEKRSLPTIDSDDDLGDLTDSFSSRCSSRDSDDWSDWEDDFEEKWVDLDPSSSSEIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9H985</accession>
    <name>E9H985_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_326941</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732608">
        <property type="protein sequence ID" value="EFX71698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71698">
        <property type="protein sequence ID" value="EFX71698"/>
        <property type="gene ID" value="DAPPUDRAFT_326941"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326941"/>
    <dbReference type="eggNOG" id="ENOG502QTS0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_257255_0_0_1"/>
    <dbReference type="InParanoid" id="E9H985"/>
    <dbReference type="OrthoDB" id="1108753at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="4">
        <location>
            <begin position="856"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="596"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="668"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1332"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="668"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX71698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1357" mass="156276" checksum="49AC1170AB9C9B5E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9C3</accession>
    <name>E9H9C3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endo-beta-1,4-mannanase</fullName>
            <ecNumber evidence="6">3.2.1.78</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MAN5A</name>
        <name evidence="6" type="ORF">DAPPUDRAFT_347627</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="6"/>
    <dbReference type="EMBL" id="GL732608">
        <property type="protein sequence ID" value="EFX71596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71596"/>
    <dbReference type="EnsemblMetazoa" id="EFX71596">
        <property type="protein sequence ID" value="EFX71596"/>
        <property type="gene ID" value="DAPPUDRAFT_347627"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_347627"/>
    <dbReference type="eggNOG" id="ENOG502RYDR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061889_0_0_1"/>
    <dbReference type="InParanoid" id="E9H9C3"/>
    <dbReference type="OMA" id="INEPEWC"/>
    <dbReference type="OrthoDB" id="1003648at2759"/>
    <dbReference type="PhylomeDB" id="E9H9C3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240948" evidence="4">
        <location>
            <begin position="20"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="5">
        <location>
            <begin position="53"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX71596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="380" mass="41191" checksum="32C6F3A697945515" modified="2011-04-05" version="1">MKMFKFVGLLLCFWASLSAGRLTTSGTNLYYNGQKVFLSGANIAWNSYGYDFGNGQYAANSKSTLESWLTQIANSGGNSVRIWLHVEGANTPAFDGNGYVTGPDSTGTMISDMRSFLDFAQSKNILVIFVLWNGAYLTVQNTINLFWDDGKLQSYIDNALKPMVSALGDHPALGAWEIMNEPEGSLLNNQADANACFDTTPLKDTGAGWTNLYIPMQNILKFVNWQADGVKGTNGAALVTLGSWSEHAQTDTKAQSRNYYTDSCLVAAGGKANGKLDFYQMHTYAFNGQWGPDAPFKVSSSSYGLNKPLVIGEFASVCAQNEGIQNLFQYGYTNGYQGVWSWQYNAGGECSDTQATQDSGMNQLKGQNGAGGAVNFPVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HBI8</accession>
    <name>E9HBI8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_256509</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
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                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Choi J.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="172"/>
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        <property type="entry name" value="Clp_ATPase_C"/>
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    <dbReference type="InterPro" id="IPR027417">
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        <property type="entry name" value="AAA_2"/>
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        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
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    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
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    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
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    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
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    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
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    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="98"/>
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        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="200"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX69276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="542" mass="61037" checksum="9D5220C3F28EE1F0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9HIL2</accession>
    <name>E9HIL2_DAPPU</name>
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        <recommendedName>
            <fullName evidence="5">Ion_trans domain-containing protein</fullName>
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    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_330121</name>
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    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732656">
        <property type="protein sequence ID" value="EFX68377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX68377"/>
    <dbReference type="EnsemblMetazoa" id="EFX68377">
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        <property type="gene ID" value="DAPPUDRAFT_330121"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330121"/>
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    <dbReference type="InParanoid" id="E9HIL2"/>
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    <dbReference type="PhylomeDB" id="E9HIL2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="60"/>
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    </feature>
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        <location>
            <begin position="58"/>
            <end position="220"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
    <sequence length="252" mass="28192" checksum="C8A29761F6D59486" modified="2011-04-05" version="1">MLLSAAVAIALPKPSGIRTPVMTVILRLICSAGPQPTLMLLGTATVVLKGVHLLSIMGNAGTFQRSVRQICTDTEIVYHVVHLIFCFLGLSTHPFFFSVLLFDVVYREETLLNVIRSVTRNGRSIVLTAVLALILVYMFSIIRLKRPSRIWSCCCLKPLCCHLVSPWKSQPSMVLAFYRMIKLGLGIDEDDVPAGGEEAKAEEEMPPLENDENASRWRKAIKRVNYCYKTQTQFLSIVLISAFLRTGMRAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9HIV6</accession>
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        <recommendedName>
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    </protein>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX68339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_63227"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX68339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="129" mass="14815" checksum="A5953A4AB2E9E097" modified="2011-04-05" version="1">MAILLSKFRIDYSDLVIITDVDEAPKSKTKKWFDGLIRPFLQPGTNGPHITEGELETYQYKTDRYLRLRDELLLDHSSDSNLVVMTLPIPRKGEFSAPLYMAWLEALTANMPPFMLVRGNQTSVLTFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HK76</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Wolf Y.I."/>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Zdobnov E.M."/>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="PhylomeDB" id="E9HKJ3"/>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="223" mass="24992" checksum="C29FB25D2C88E315" modified="2011-04-05" version="1">MKDLVTKISSHGDITSDEFARGMSEFRNTPRENGKSPAEMVFGHPLRSIIPAHRTAYATHWRSAMEGRDRQTAIDAEVKFRYDEHARPLAPLPLGTHVWVREPKTKLWDKFGVVVSIGRYRSYRIKFASGSVLWRNRRFLRPMVAVPETNEPPAFHDGDGAGDSTDVQHAAAGQTDGEQRDNFPGASLHLGATSSSVDTSADAGRQPVRRSERVRKKRVIFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLS1</accession>
    <name>E9HLS1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_115552</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732681">
        <property type="protein sequence ID" value="EFX67312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67312">
        <property type="protein sequence ID" value="EFX67312"/>
        <property type="gene ID" value="DAPPUDRAFT_115552"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_115552"/>
    <dbReference type="HOGENOM" id="CLU_1108031_0_0_1"/>
    <dbReference type="OrthoDB" id="1861323at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="251" mass="27887" checksum="22395C209A8FB04E" modified="2011-04-05" version="1">MDLVHLSGGLLVNKASISDPVFVIFGPGVKWLKKAEKLHRRLVFSHVSNSSAPSFRANSTATRRRRRTILPKAKGGIQRKSRRYRKQQSRISRAPSPAIEAAAIEAAAIEAVDVVVEEPADDAVVPLVIGIADQHSRPRLADFVPPPTSRRVVYRPYDRWPSPEEPPTPPGEPESEEEDFIPNLSDCEVRSEVGPSSDDEAPEPTSPPPPTPPSPPRRVVQIRNTKTNKTRCIGLDQLFRPESQDKIVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E9HND5</accession>
    <name>E9HND5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="4">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="4">HAD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_302443</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 4">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 3-HAO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="4"/>
    <dbReference type="EMBL" id="GL732695">
        <property type="protein sequence ID" value="EFX66740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66740"/>
    <dbReference type="EnsemblMetazoa" id="EFX66740">
        <property type="protein sequence ID" value="EFX66740"/>
        <property type="gene ID" value="DAPPUDRAFT_302443"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302443"/>
    <dbReference type="eggNOG" id="KOG3995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064845_0_0_1"/>
    <dbReference type="InParanoid" id="E9HND5"/>
    <dbReference type="OMA" id="WQMEGSS"/>
    <dbReference type="OrthoDB" id="1325876at2759"/>
    <dbReference type="PhylomeDB" id="E9HND5"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046874">
        <property type="term" value="P:quinolinate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="PTHR15497"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 4" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Domain A (catalytic)" evidence="4">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Domain B" evidence="4">
        <location>
            <begin position="162"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX66740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="288" mass="33146" checksum="B89B54E61ABF09A8" modified="2011-04-05" version="1">MSIQLCNINQWIEDNKASFLPPVCNKLMHEKQLKVFFVGGPNQRKDFHIEEGEELFYMKKGSMELIVQEQGAFKTVAIQEGQVFLLPGKIPHSPQRKDDTIGLVVERERAKQELDCLRYFVNDSTESLFERWFYCDDLGVQLVPVIKEFFASEQCKTGRPVPGTIPENPHFHPDGQLQLENPFNLKEWLQSHRTEIHQNGKKNLFDGAKYKSDVIIYGKGVDEFKPIQHEIWLWQLEGESVVKLNGQDITLKSDDSLLIPAGEEHQLMRDADSCFLMSVAMPTPNENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNF7</accession>
    <name>E9HNF7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_64407</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732695">
        <property type="protein sequence ID" value="EFX66752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66752"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_64407"/>
    <dbReference type="eggNOG" id="KOG4423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_6_1"/>
    <dbReference type="InParanoid" id="E9HNF7"/>
    <dbReference type="OMA" id="HQSFPSE"/>
    <dbReference type="OrthoDB" id="373256at33208"/>
    <dbReference type="PhylomeDB" id="E9HNF7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX66752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="189" mass="21499" checksum="BEE469C00E40211B" modified="2011-04-05" version="1" fragment="single">SSSSLAKRKYYKLLVIGDQNTGKTSIIHRYVHGSFRDKYEVTVGAGINFKEIAWNNTDHLTLEFFDIGGEERSRFMTSAFYRKAVGAFVVTDVTQPNGFQAATLWKKDLDMKLRMHDDTLLPCVLLINKCDGATADQKHSSNELDPSQVDRFCRHQKFSGWFDTSAKNDINIDEAVQFLVGKVIRRNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNP3</accession>
    <name>E9HNP3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_331866</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732697">
        <property type="protein sequence ID" value="EFX66652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66652">
        <property type="protein sequence ID" value="EFX66652"/>
        <property type="gene ID" value="DAPPUDRAFT_331866"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_331866"/>
    <dbReference type="HOGENOM" id="CLU_589587_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX66652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="464" mass="50839" checksum="DF28319AD639E0AF" modified="2011-04-05" version="1">MPASQNIRQNPAKANVDVENEEPQTENVELNKEKEVVGVHVSHIQKVKVWSQRTKRTQHPSSTVTITLTQSEDGTYFPPPHLIDQLDAWELGVSPSLTINTLALPSSGQLLLEIATESKSDGTCRTGASNVAASELPVPVNGTKRTVPVRVQQQLQLSSIQHRRHLVPLVLKPVELTTMTASNPSSFLPVTLMKHPNYQPLKLDNEERKMEANQLARDAGVELFIFGYFPNVTVGSCATWAFGEQTKNIVTKPTAKSFLKHWENVFSLKEAKANVDVENEEPQTENVELNKEKEVVGVHVSHTGSVGESVEQTSKESEAGGVESSNKESFEPESEHFPSHLIPGTQHPSSTVTITLTQSEDGTYFPPPHLIDQLDAWELGVSPSFTINTLAPPSSGQLLLEMTTESTSDGTCRTGASNVAASELPVPVNGTKRTVPVRVQQQLQLSSIQHRRHLVPLVLKRQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9HNY3</accession>
    <name>E9HNY3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_231816</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732700">
        <property type="protein sequence ID" value="EFX66544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX66544"/>
    <dbReference type="EnsemblMetazoa" id="EFX66544">
        <property type="protein sequence ID" value="EFX66544"/>
        <property type="gene ID" value="DAPPUDRAFT_231816"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_231816"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_7_0_1"/>
    <dbReference type="InParanoid" id="E9HNY3"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="PhylomeDB" id="E9HNY3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241239" description="Peptidase S1 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="25"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX66544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="258" mass="27872" checksum="70718D094091697B" modified="2011-04-05" version="1">MKLTTLLTALAFVALTSGAPSEDRIYGGATTTTAIPYLVSIVVNEQHVCGGWIYNNDWIVTTASCVVNYEPSQLSVIAAQVSLLQPDTDEVSVNVFKIYRYSSTYDPLTKLDDIAMLQLATPLTFGTNVNFVRYEEAVEDGTIEAVFAGWGGTLEGNLPSTKLRTMTVTFPGDCSTYTAEEYKQNYMLCAGTATDTSSPCQYDEGSPLVQNIDGVDYAVGIMSKNKGCGVAPATSTVYTRLSAYYAWFNTIAGLQPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HPE0</accession>
    <name>E9HPE0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_263234</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Basu M.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="gene ID" value="DAPPUDRAFT_302741"/>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Andrews J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732734">
        <property type="protein sequence ID" value="EFX65694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX65694"/>
    <dbReference type="EnsemblMetazoa" id="EFX65694">
        <property type="protein sequence ID" value="EFX65694"/>
        <property type="gene ID" value="DAPPUDRAFT_332953"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_332953"/>
    <dbReference type="eggNOG" id="ENOG502R3BX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_883553_0_0_1"/>
    <dbReference type="InParanoid" id="E9HRF3"/>
    <dbReference type="OMA" id="DAIWINC"/>
    <dbReference type="OrthoDB" id="1374406at2759"/>
    <dbReference type="PhylomeDB" id="E9HRF3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="PTHR23423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX65694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="315" mass="35490" checksum="FA11B55F2BCDE414" modified="2011-04-05" version="1">MEENCSMLTFNTRPPNVLQHLEALGYYGWISTITFGVTTLILVALFIANVAGFIRHSPPHRRLLLCWVTSFPMIISFLALMTLLIPRAGNLCDTVKQIFMPFTMMHFVDLTLNFKGGQSAALEDLLQSNTPMSLCLPPCCCVGLCVRQLDYTKKRLRVLKSLVYQMPLVQLAIIVLIVLLTEAEVIRRDKGPDGVFLFLNVLNIVCFCLAMWAFNIITRSFAPQLTAINFLYKAQLVGLGIMLMKLQNFVLVILSVSGVVPCIAPVTSRIVLQKTIDASLTLFEAFILGILTFIEYRKLDRQNEEGPRRRQSQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9HRG0</accession>
    <name>E9HRG0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA guanylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_117076</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="1"/>
    <dbReference type="EMBL" id="GL732735">
        <property type="protein sequence ID" value="EFX65670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX65670"/>
    <dbReference type="EnsemblMetazoa" id="EFX65670">
        <property type="protein sequence ID" value="EFX65670"/>
        <property type="gene ID" value="DAPPUDRAFT_117076"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_117076"/>
    <dbReference type="eggNOG" id="KOG2386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021710_3_0_1"/>
    <dbReference type="InParanoid" id="E9HRG0"/>
    <dbReference type="OrthoDB" id="1544021at2759"/>
    <dbReference type="PhylomeDB" id="E9HRG0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA_cap_enzyme" evidence="7">
        <location>
            <begin position="195"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA_cap_C" evidence="8">
        <location>
            <begin position="271"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX65670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="398" mass="45996" checksum="7F75A9F15371C3F2" modified="2011-04-05" version="1">MVFSSAKNMKLKIGLWIDLTNTSRFYDKNALNWSVGAAVKEFSKARYPGIYKEHYIRELFTLYGDTDDAPLAPALPMWDCEADDDTPSREETEAVDDDDQVGGSTGEKKKKKHDEKWHKRMPSSWKFPWIEGTSNYCNIPTKCRGKLTAPDRNNTVFQIEGVSFFSSQIDNHHLVDTLIDGEMVIDKADGMRYLIYEEIIEPRKDAMKSGRIIREREPIGIRRKEFWHVSVTSALYKGEKFMRQLGHEPDGLVCQPIEECSSVLKWKPPSHNSVDFRLRIVIENRPGMLRERIGHLYVGGKNDTPFAIMKATKEMVPLDNKIIECRYEMNNGNGKWVFMRQRTDKSFPNSCNTATAVCQSIREPVMKEILEDFILNLRAQHSSQQQDEDLSLNFHKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9HRJ4</accession>
    <name>E9HRJ4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_1432</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732737">
        <property type="protein sequence ID" value="EFX65623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX65623"/>
    <dbReference type="EnsemblMetazoa" id="EFX65623">
        <property type="protein sequence ID" value="EFX65623"/>
        <property type="gene ID" value="DAPPUDRAFT_1432"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_1432"/>
    <dbReference type="eggNOG" id="KOG1473">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019033_0_0_1"/>
    <dbReference type="InParanoid" id="E9HRJ4"/>
    <dbReference type="OMA" id="SHATRAC"/>
    <dbReference type="OrthoDB" id="32123at2759"/>
    <dbReference type="PhylomeDB" id="E9HRJ4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <location>
            <position position="1"/>
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    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="646"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50827"/>
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    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX65623.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
    <sequence length="646" mass="73596" checksum="ECAB0BCDBB0D97FA" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E9HRP6</accession>
    <name>E9HRP6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DAPPUDRAFT_333049</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9HRP6"/>
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    <dbReference type="OrthoDB" id="172471at2759"/>
    <dbReference type="PhylomeDB" id="E9HRP6"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of ion transmembrane transport"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="EF_hand_dom"/>
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        <property type="entry name" value="GPHH_dom"/>
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        <property type="entry name" value="Ion_trans_dom"/>
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        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR10037"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 14" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="9 14" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
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            <begin position="35"/>
            <end position="52"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
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    <feature type="transmembrane region" description="Helical" evidence="16">
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    <feature type="transmembrane region" description="Helical" evidence="16">
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    <feature type="transmembrane region" description="Helical" evidence="16">
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    <feature type="transmembrane region" description="Helical" evidence="16">
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    <feature type="transmembrane region" description="Helical" evidence="16">
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
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    <feature type="transmembrane region" description="Helical" evidence="16">
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        <location>
            <begin position="1324"/>
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        <location>
            <begin position="1363"/>
            <end position="1398"/>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003808"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX65595.1"/>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX65560.1"/>
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        <property type="gene ID" value="DAPPUDRAFT_264547"/>
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    <dbReference type="eggNOG" id="ENOG502RVV2">
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            <begin position="409"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX65560.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    </protein>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX64514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="113"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX64514.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="324" mass="35685" checksum="E73E0922603397F5" modified="2011-04-05" version="1">MSLDSSANLLSSGSKLESAASLSLPEGPATYLDSSANLPPPDSKPESATAPSFSERPAASLDKRQSSPKYPKKAVLSLLRGSASVLGKQHDSTAKKTKSTPSIKPIIMETQNRQENPDEGELPSEEAPEADDDKQTDLTASLEEFRTRNSPTRKHLERVTPLRLDKESTKAENLIDQLLRVKLSIQVSNTNLSQQIINVFVLVTEVRLIRRFLQFVWDPGGKATNRVSRLSLGPASETSLTPATKRNDQQEDELTNSKRTRSQRNSCSLVFTLPEPAVLASLPTNQKMIQPTIQPSISNPMEWALVGSMLEMKWTSNRCLNYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9HV12</accession>
    <name>E9HV12_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Diacylglycerol kinase</fullName>
            <shortName evidence="8">DAG kinase</shortName>
            <ecNumber evidence="8">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Tang H."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX64421"/>
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        <property type="gene ID" value="DAPPUDRAFT_334212"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_334212"/>
    <dbReference type="eggNOG" id="KOG1169">
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    <dbReference type="PhylomeDB" id="E9HV12"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0046339">
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0046834">
        <property type="term" value="P:lipid phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007205">
        <property type="term" value="P:protein kinase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DAPPUDRAFT_269778"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="61" mass="6605" checksum="94F2985577AC952F" modified="2011-04-05" version="1">MKKTSGLDILLQNVRTQQSLSSMAGIMATVVSLQPDGERRDLVKLSCSILHAVYRAGLSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
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            <taxon>Anomopoda</taxon>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GPCR_2-like"/>
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        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
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        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="348" mass="38409" checksum="395337AA1A5248AB" modified="2011-04-05" version="1" fragment="single">CRTVYCSQPGTFYREGRCYGLPPNPLSDTTTTITTTTTTTTTTTIADDVTAVTDANEVVFPKQKDSKGFYTEELTNSSAPQLPEIILNIADPSTEISTMENEGFPTTTTTFSSIIPVNMTDDAQSSTETNFTSCPKFLLSEDEVEWLENGTLYVPSHEKPYEVGHYEKSKDGILICAEGLTLVSKFDPVLGWVTVAGLGLSEVCLALHLIAFIISPDLRNLSGRNLASLSLALFAAYGSFIIAQFVPTGGNICVAVALCTFYFFLSAFWWTSVLAWDVWRTIRLATVQLRCSSSGQQWGKFILYSMYAWLLPGLIVAAAVAVEYVDTDAFSWMPTEYRPFFGRNVVWL</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX62267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="E9I163"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_120887"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1340481_0_0_1"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="205" mass="22769" checksum="ADC4837CAC47F227" modified="2011-04-05" version="1" fragment="single">MADLLTNATTSAAGTGASHSGPCTVFVRGTIASGATVTIEVADEDVSASYVKADESIMRESRFAAKGCCALNAYGTYYWYERYGGDDAVKLCKCGAIVGRRCEKCYPQKHDRTTKQRGYDNKHRVASERYRVEHPLCERCVMIGGVEQANVTEHMHHIVKVSDAEQLRMRSDNWLGVCVDCHETLENDVAQGMKVKQWSLANYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2T9</accession>
    <name>E9I2T9_DAPPU</name>
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        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </feature>
    <feature type="non-terminal residue" evidence="2">
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_340639"/>
    <dbReference type="HOGENOM" id="CLU_019667_0_1_1"/>
    <dbReference type="PhylomeDB" id="E9I4H5"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241477" evidence="1">
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            <begin position="20"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX61105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="291" mass="33140" checksum="99AB008F79E322BC" modified="2011-04-05" version="1" fragment="single">MFVLRMLLLLGLYALGLNALEVTVCDCEQASQKGILQFSDEDCQPEKNENRTNAVNYSVYTEKREELKFPGYICARWKQIKHITTSFFGQKVVLPDKIALETSPLECLLMYESRRCNEQPMTINDNKFFYDQEPVEDGWWLETVTVETINCAVKKIQLYQETEGESFSTPLGIAPATAGSISHNHLTLIWDKTFTVKSEPKARLVESGVAIIITTGKSNKFRMHDEEKELEFHIQITNKRCLPPLTTCDVKADAFDVIGQSKLYIFTTPIIPKNSSLEEGSRKRPVLKEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9I4M1</accession>
    <name>E9I4M1_DAPPU</name>
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        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3">
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        <name type="common">Water flea</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX61059"/>
        <property type="gene ID" value="DAPPUDRAFT_340710"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_889234_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9I4M1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX61059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="314" mass="34935" checksum="50131E481F2F4BEF" modified="2011-04-05" version="1" fragment="single">MLNINVCKSRTKEAILTIDSLPDDDLTAKDNKLVAPEPVLEPKDIIPAEVSPFKEQLETEEKKSVQVDTKVEKPKEIPAIEQKLEASQNNPELKNNQTKEAILTINGSLSFDDNPEPPVSEPVIPIPTDIPVDCNTDCNTEVVIPPSNEPLEMLDEREPESLSIMPEPIADSTGNVTNEDPVLGETQLDEIAKEMIIPEEIERVEEDPLAEAQSNKITDDKQSKDDEMRRVSREFRPSTERDIIDEVSALSKLMVPDEEMIIPEESERVEEQPAAGEAQSKSTADGHQLTDEDSVNRQSPLLTEEEIDDEPTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9FR75</accession>
    <name>E9FR75_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_190238</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90244"/>
    <dbReference type="EnsemblMetazoa" id="EFX90244">
        <property type="protein sequence ID" value="EFX90244"/>
        <property type="gene ID" value="DAPPUDRAFT_190238"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_190238"/>
    <dbReference type="eggNOG" id="KOG2429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_5_6_1"/>
    <dbReference type="InParanoid" id="E9FR75"/>
    <dbReference type="OMA" id="NWTFVKD"/>
    <dbReference type="OrthoDB" id="434316at2759"/>
    <dbReference type="PhylomeDB" id="E9FR75"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904382">
        <property type="term" value="P:mannose trimming involved in glycoprotein ERAD pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="PTHR45679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="SSF48225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240243" description="alpha-1,2-Mannosidase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX90244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="591" mass="66924" checksum="859C59E92CD4647C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRI5</accession>
    <name>E9FRI5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_232735</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX90193">
        <property type="protein sequence ID" value="EFX90193"/>
        <property type="gene ID" value="DAPPUDRAFT_232735"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_232735"/>
    <dbReference type="HOGENOM" id="CLU_348606_0_0_1"/>
    <dbReference type="OrthoDB" id="293577at2759"/>
    <dbReference type="PhylomeDB" id="E9FRI5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX90193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="809" mass="95285" checksum="F89821C90862A572" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9FS30</accession>
    <name>E9FS30_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EOG090X0EJQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EOG090X0EJQ</name>
        <name evidence="4" type="ORF">DAPPUDRAFT_299834</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TCO</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015541">
        <property type="protein sequence ID" value="SVE85160.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90389"/>
    <dbReference type="EnsemblMetazoa" id="EFX90389">
        <property type="protein sequence ID" value="EFX90389"/>
        <property type="gene ID" value="DAPPUDRAFT_299834"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299834"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="entry name" value="Methyltransf_PK"/>
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            <begin position="125"/>
            <end position="126"/>
        </location>
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        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
    </feature>
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        <location>
            <position position="81"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX90389.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="232" mass="26089" checksum="7A320F79C900A6DC" modified="2011-04-05" version="1">MDNNGELSQDVKVDSKESAFYVDAAKYWEQVPPTVDGMLGGLSSISDIDLKGSQRFLNSLYQLVECPGKERALDGGAGIGRVTQGFLMKNFPVVDLVEQDKQFLDEAEKALEPTNHKGQFFNIGLQKFTPEACVYDIMWVQWVLGHLTDDDLISFFIRCKSGLKPKGLLVLKENLTSSGEVEMDSTDSSVTRPRALIIELIKKAGLRVIKEQKQQRFPHELYEVRMFAIQPV</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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    <accession>E9FTS5</accession>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX89420.1"/>
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    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_303034"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="88" mass="9782" checksum="E69D37E9FB8E227B" modified="2011-04-05" version="1">MKTQKTTDQTFNAATQNITGRAISYGMDENTNTKMLKSGTQMQRLSYNSTATSGLHCNRMLLQWFNLSSSHLSPFGCNKVTTSVCFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9FUP2</accession>
    <name>E9FUP2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glutamine synthetase</fullName>
            <ecNumber evidence="2 5">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_206496</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="2 5"/>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88765"/>
    <dbReference type="EnsemblMetazoa" id="EFX88765">
        <property type="protein sequence ID" value="EFX88765"/>
        <property type="gene ID" value="DAPPUDRAFT_206496"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_206496"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036762_1_1_1"/>
    <dbReference type="InParanoid" id="E9FUP2"/>
    <dbReference type="OMA" id="QIMGMVE"/>
    <dbReference type="OrthoDB" id="784869at2759"/>
    <dbReference type="PhylomeDB" id="E9FUP2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="6">
        <location>
            <begin position="113"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX88765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="366" mass="41138" checksum="986933F7970D481A" modified="2011-04-05" version="1">MAGLMTNASATNKAVLDRYMRLPQPDDKVMATYVWIDGTGEYVRAKTRTIDFIPKTPSELPIWNYDGSSTYQAEGSNSDVYLYPVAIYRDPFCLGNNRLVLCDTYKYNKRPTESNHRNSCLEAMNSAAEYEPWFGIEQEYTLLDNDLHPFGWPKNGFPGPQGPYYCGVGANKVFGRDIVEAHYRAALYAGVNISGTNAEVMPAQWEFQVGPCEGITMGDDLWMARYILHRVAEDFGVNVSLDPKPMKGEWNGAGAHCNFSTKAMREENGIAEIEKAIEKLSRCHVKHIKAYDPHEGKDNERRLTGRCETSSIHDFSAGVANRGCSIRVPRGVAEERKGYLEDRRPASNSDPYQVTEVVVRTTCLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9FV33</accession>
    <name>E9FV33_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_310665</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88486">
        <property type="protein sequence ID" value="EFX88486"/>
        <property type="gene ID" value="DAPPUDRAFT_310665"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_310665"/>
    <dbReference type="HOGENOM" id="CLU_3144333_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX88486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="49" mass="5501" checksum="B32C0561F7BAE920" modified="2011-04-05" version="1">MSARNSFEINLLVSSDPQSVTFSESDLNKIKEVQTGFDFSLSKEPEKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9FX52</accession>
    <name>E9FX52_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbonic anhydrase</fullName>
            <ecNumber evidence="4">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CAA6F</name>
        <name evidence="6" type="ORF">DAPPUDRAFT_442468</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88012">
        <property type="protein sequence ID" value="EFX88012"/>
        <property type="gene ID" value="DAPPUDRAFT_442468"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_442468"/>
    <dbReference type="eggNOG" id="KOG0382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039326_2_0_1"/>
    <dbReference type="InParanoid" id="E9FX52"/>
    <dbReference type="OrthoDB" id="1377476at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="PTHR18952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="SSF51069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025097066" description="Carbonic anhydrase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="5">
        <location>
            <begin position="159"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX88012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="454" mass="49456" checksum="1419EB09C95DE31B" modified="2011-04-05" version="1">MQVSRPNGILAIVVVFMGLLAPTKCFPIIGEPFVAPEFLPTTARANPAIPEAIPYTRIPYTPSTAAPKENAAYPSPSTYSYTLKPEVTTTALSSTSDKIQSIVATTTSTIDAPGLAATSAITTSSIIPSDATTSPPVNAGRVDDSAFEHFSLKPHQAKPSWTHKDSVGWHSKFPTCGGSQQSPIDIQPKSTVLTAYPKFTFHNYGNLISMELINNGHSAVYNLPPDYPTEEMPHITGGGLDDTFAFVQFHLHWGSESSKGSEHLIKSKGYPGELHLVHFNTKYGSFAEASQHSDGVAVLGIFLKVGPSDSQSFQPLVEQLGEISKDGDETVLRKPVALNDILPGRTSSFYRYSGSLTTPNCQQIVIWTIFDNPIEISEKQLDKFRSLQGDDGFNMVNNFRPTLPVNGRTVFYRSFTGCEIPRSWPITSSPFSEAYKWSKCLMGFAYKSVAPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXE6</accession>
    <name>E9FXE6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAM86 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_234781</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88280"/>
    <dbReference type="EnsemblMetazoa" id="EFX88280">
        <property type="protein sequence ID" value="EFX88280"/>
        <property type="gene ID" value="DAPPUDRAFT_234781"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_234781"/>
    <dbReference type="eggNOG" id="KOG2497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038942_0_1_1"/>
    <dbReference type="InParanoid" id="E9FXE6"/>
    <dbReference type="OMA" id="CWQASCD"/>
    <dbReference type="OrthoDB" id="958308at2759"/>
    <dbReference type="PhylomeDB" id="E9FXE6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029426">
        <property type="entry name" value="FAM86_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="PTHR14614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14904">
        <property type="entry name" value="FAM86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM86" evidence="2">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX88280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="335" mass="38412" checksum="158EBEB4E22DFFBA" modified="2011-04-05" version="1">MFEQFTKSFLARIPVSKLDWKFIEETLNQSSELGRVNGNEDEMFLCQENILNATVHHPLNLKYPLPDVYIHSFLKCLINMVERFHCEIHSNILEKYTNLICKNLSTVEAGHRSFMIDETTSISLRENISIISDGTTGLCTWQAAFHLAEWCIANRQRITGMTVVELGSGAGLVGLTCYKTCKPGYITMTDFHPKVMETLRYNLENNQLIENSSPPIDIQPLDWMEFHTKSESSLQADLVLASDVVFDVELIPALVGTLSKLLHPRDNKLLPSAIVACTERNQETLNRFLYELAQQNLTYGHLEHAPSIFACERNYPRRLKMCPRNRQTKEEDRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXW0</accession>
    <name>E9FXW0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_221374</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88223"/>
    <dbReference type="EnsemblMetazoa" id="EFX88223">
        <property type="protein sequence ID" value="EFX88223"/>
        <property type="gene ID" value="DAPPUDRAFT_221374"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_221374"/>
    <dbReference type="eggNOG" id="KOG0441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_716236_0_0_1"/>
    <dbReference type="OrthoDB" id="1574423at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="PTHR10003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="SSF49329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003236933" description="Superoxide dismutase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Cu" evidence="11">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX88223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="386" mass="43365" checksum="D5099E7E434EF621" modified="2011-04-05" version="1">MLSIFTLRFCTILFIIQWSRAVPVSETSDLAELRDSVSKLWKALRELESEVRESFDIHAAIENHEHQVHHLGHEDNGHEIHHSERHLKHLEQVHGRTVAGPAGIEPHKPHTPDEKEILRHEHEFHHANASFETEEEHKAHHDEKMLKHLELDHGHGEHNGIHHGKMNKEIEHEIDVHFMLRNHDGHASHHNENLLKHLEDDDGHGPAADRPKPVTTPKPPRGSKTYQAVCEMKPNKALQRTKHNIVGKVAFTQTTGGPLNVHVNLRGLRTNGKSLHGLHVHELVPDEDGNCNQAGGHFNPTSSVHGGPKSRTRHVGDFGNVEAIENQGINAMFTDSLATLTGPNSILHRTLVIKEKEDDLGQNRDTESLANGNTGRRLACCIIRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYD2</accession>
    <name>E9FYD2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_96608</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87792">
        <property type="protein sequence ID" value="EFX87792"/>
        <property type="gene ID" value="DAPPUDRAFT_96608"/>
    </dbReference>
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    <sequence length="308" mass="34178" checksum="65133E27FA64240B" modified="2011-04-05" version="1">MADTKPQRRRLTTQKQLTQRPVTAPKSSKYYTTKAPDLNSTTYAAPSHYTDALKYYSAPSTSTTKATEDDYACCPILRGSYTEAPNCYTEVPADYYTEASKYYSAPIYTTITEAAKYYAVPTYCREAALSYYVEQEYYTDAPVHYTTTYATPQPPTTTYAAEFTTPSSQLSLMAGSTAGVAMSPWYGGNQTATPPPSYSTYATTSSCTDVFKYYTTKAPDLNSTTHAAPSHYTDAPNCYTEAPADVSTKTVEYYTEATKYYSAPIDITTTQAAKYYAVPTCYTKAALSCCVEQRYYTDAPVYYTTTYT</sequence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYQ3</accession>
    <name>E9FYQ3_DAPPU</name>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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</entry>
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    <accession>E9FYT9</accession>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G060</accession>
    <name>E9G060_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_235549</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX86845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86845">
        <property type="protein sequence ID" value="EFX86845"/>
        <property type="gene ID" value="DAPPUDRAFT_235549"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_235549"/>
    <dbReference type="HOGENOM" id="CLU_1837128_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX86845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="140" mass="16093" checksum="226FA0718EA4FCB0" modified="2011-04-05" version="1">MERTKKANVIINPLENDRRYDRGAAASSSERMDGWMGGANTKTISLHIHPGMRAITLLLPHRHRRSIQPTAQCHGDRVYFNQRAPYNHMRKALSEAKEFGLQLPLPFLPKGRKEIDHFGMMNQQRPSLCSYTNHQHFGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9G0Z0</accession>
    <name>E9G0Z0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_4188</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87321"/>
    <dbReference type="EnsemblMetazoa" id="EFX87321">
        <property type="protein sequence ID" value="EFX87321"/>
        <property type="gene ID" value="DAPPUDRAFT_4188"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_4188"/>
    <dbReference type="eggNOG" id="KOG1026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_7_40_1"/>
    <dbReference type="InParanoid" id="E9G0Z0"/>
    <dbReference type="OMA" id="NCPRDIY"/>
    <dbReference type="OrthoDB" id="471114at2759"/>
    <dbReference type="PhylomeDB" id="E9G0Z0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038062">
        <property type="term" value="F:protein tyrosine kinase collagen receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033674">
        <property type="term" value="P:positive regulation of kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:transmembrane receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX87321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="243" mass="26758" checksum="2ADB153D956D885A" modified="2011-04-05" version="1" fragment="single">VAVKVLKAAAGPAAQEDLLQEAEIMVSFSHPNILSLKGIPNIGPWLVFEYMALGDLAQLLRSANGNLFAKTKTAHCLNQEDLHSIAAQIADGMAYLSSQHFVHRDLACRNCLVGERPRGGGLAVKISDFGMSRDVYTCDYYKIGGSRMLPVRWMAPESILYGKFTLESDVWSFGVVLWEVFALGVQPYYGHSNEQVVKLILQGILLTPPSSAPPLICQLLNGCWKTQPGDRLTFAEIHSKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1B2</accession>
    <name>E9G1B2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_236573</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86668"/>
    <dbReference type="EnsemblMetazoa" id="EFX86668">
        <property type="protein sequence ID" value="EFX86668"/>
        <property type="gene ID" value="DAPPUDRAFT_236573"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_236573"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000038_0_2_1"/>
    <dbReference type="InParanoid" id="E9G1B2"/>
    <dbReference type="OMA" id="LYGIMEW"/>
    <dbReference type="OrthoDB" id="2079at2759"/>
    <dbReference type="PhylomeDB" id="E9G1B2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036156">
        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9G391</accession>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Crease T.J."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Geiler-Samerotte K.A."/>
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        </source>
    </evidence>
    <sequence length="318" mass="35078" checksum="9B363C597FBDB2F3" modified="2011-04-05" version="1">MEKMKATMGQRPVTKKKVTFVHNQYNSPLDLYSADEVAQTLRRHASLLSNGAIGIDFGSLSSPVLKRSQVYKMLTEEQQEQQERRPWQLHHKKSTSSVCNFIKMKRVAWPPVSAEIAKTNENDNGIIGDDEVEQRHHQDASNSNRFSTTTNQQMPNGSKVAPPVPPKPGAREIANAQQSADYDSDNTMASSNGLPEAFASNELVGERLLIAKPAPPPGLILLKKHAPISQEPQAVFNSQPVFKRATPVRMLGDMVWPPKGAGGASDNSTQSPGLVRRQPKNYQEFFGSNQLPANFPTYRAPPGTQHFGLEEGENTTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9G4R1</accession>
    <name>E9G4R1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Microsomal glutathione S-transferase 3 isoform b</fullName>
            <ecNumber evidence="6">2.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_300290</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Liu Z."/>
                <person name="Zhang W."/>
                <person name="Zhao Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EC" id="2.5.1.18" evidence="6"/>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MN730121">
        <property type="protein sequence ID" value="QNM80615.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85346"/>
    <dbReference type="EnsemblMetazoa" id="EFX85346">
        <property type="protein sequence ID" value="EFX85346"/>
        <property type="gene ID" value="DAPPUDRAFT_300290"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300290"/>
    <dbReference type="eggNOG" id="ENOG502S4E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110291_1_0_1"/>
    <dbReference type="OMA" id="AFKFNCA"/>
    <dbReference type="OrthoDB" id="1609516at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="SSF161084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX85346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QNM80615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="158" mass="17201" checksum="5B6EA7164E714DBE" modified="2011-04-05" version="1">MVVCSKFATVLASGTGTFVEIPSDYGYVVFAGIASGILLAWQSIQVGKMRRRFGIHYPIMYSPETTGNGQLFNCYQRAHQNTLENYPLVLMLLFTGGLQYPIPAALGGAVWIAGRVAYSKGYYTGDPTKRMRGSFGYLGLAILFGSSSMFGAKLLGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9G5E9</accession>
    <name>E9G5E9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">39S ribosomal protein L22, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_45963</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85195"/>
    <dbReference type="EnsemblMetazoa" id="EFX85195">
        <property type="protein sequence ID" value="EFX85195"/>
        <property type="gene ID" value="DAPPUDRAFT_45963"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_45963"/>
    <dbReference type="eggNOG" id="KOG1711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100005_1_0_1"/>
    <dbReference type="InParanoid" id="E9G5E9"/>
    <dbReference type="OMA" id="YSHYFVR"/>
    <dbReference type="OrthoDB" id="1054896at2759"/>
    <dbReference type="PhylomeDB" id="E9G5E9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX85195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="176" mass="20660" checksum="7B708A3035AC4179" modified="2011-04-05" version="1">MAQQQKGPKKWPIYNKKMFPPQLPGEERRPAYVCHMRTNIKYSPFKMWYVASMIRGMSIDEALKQLSFVNKLGAVHVKEALLEAQKLAVEKHNVEFKSNLWVAESFATKGLVYKGVRRHAKGRVGVIHYFHTHYFVRLEEGTPPQHFYFETVPKTTKTLLSEWVDEMRQRRIPLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G623</accession>
    <name>E9G623_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_238299</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX85069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX85069"/>
        <property type="gene ID" value="DAPPUDRAFT_238299"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2707284_0_0_1"/>
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        <source>
            <dbReference type="EMBL" id="EFX85069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="73" mass="8536" checksum="F493C5710B270B6B" modified="2011-04-05" version="1">MSNFDCVTRTTTNCWNVAIELELNGGERNESMTNATRFLLHHQSACTRIYKQSYGFFLASFTYTRRSPFIVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9G6H9</accession>
    <name>E9G6H9_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732533">
        <property type="protein sequence ID" value="EFX84940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX84940"/>
        <property type="gene ID" value="DAPPUDRAFT_238472"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238472"/>
    <dbReference type="HOGENOM" id="CLU_3108475_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9G6H9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX84940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="51" mass="6151" checksum="2FEE7D907C5B4B78" modified="2011-04-05" version="1">MYRDLLNTEPHFSHLLYACHPLVQTCAVNANNMHTTLRIDIRYCCRRYIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7W9</accession>
    <name>E9G7W9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_24797</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84557"/>
    <dbReference type="EnsemblMetazoa" id="EFX84557">
        <property type="protein sequence ID" value="EFX84557"/>
        <property type="gene ID" value="DAPPUDRAFT_24797"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_24797"/>
    <dbReference type="eggNOG" id="KOG2287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036849_0_0_1"/>
    <dbReference type="InParanoid" id="E9G7W9"/>
    <dbReference type="OMA" id="HSYECEY"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="PhylomeDB" id="E9G7W9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX84557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="285" mass="32384" checksum="D9BBB1C04C94B9ED" modified="2011-04-05" version="1" fragment="single">LVNLKNFEFLLNSDACGTRQIDLLVIVTSHPGHVALRNAFRRALPIEALRTFNITRVFLLAQINPIQTGYHQVDQHVIEEEHINYNDIVQGDFIESYHNLSYKHVMGLKYSAHYCSQAQLILKMDDDIAVDLFQLLDLVRRKLLTGLQIAGAVLTGDERNPVRDKASKWYVSRDDYAPSKYPPFVSGWAYVTTVQAASQLVRHSESSPFFWIDDIYVTGMLAALSGVNLVDIRTRFTVFVDHLKCCLREHPITVACDYIIGPSGDDAELVEAFHRQSLRCRIDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9G828</accession>
    <name>E9G828_DAPPU</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84758">
        <property type="protein sequence ID" value="EFX84758"/>
        <property type="gene ID" value="DAPPUDRAFT_238571"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238571"/>
    <dbReference type="HOGENOM" id="CLU_1373481_0_0_1"/>
    <dbReference type="InParanoid" id="E9G828"/>
    <dbReference type="PhylomeDB" id="E9G828"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX84758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="183" mass="20383" checksum="B2CC176F8E85A439" modified="2011-04-05" version="1">MTTHAAPSYYTEAPNCYTEAPAATPRLQLLHRGSSCYTEAPAATPRLQLLHRGSSCYTEAPAATPRLQLLHRGSSCYTEAAMHYSAPIYTSITVAAKYYAVPTYCTEAALSSLHDDLRYTAAPKYYTEEAAYNNAPKYYITKAPEFYTSMYAAPAYYTDASHYYNTEALKYYTTTCAAPSYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9G917</accession>
    <name>E9G917_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4789 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_315199</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84175">
        <property type="protein sequence ID" value="EFX84175"/>
        <property type="gene ID" value="DAPPUDRAFT_315199"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315199"/>
    <dbReference type="HOGENOM" id="CLU_790523_0_0_1"/>
    <dbReference type="OrthoDB" id="1574404at2759"/>
    <dbReference type="PhylomeDB" id="E9G917"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031993">
        <property type="entry name" value="DUF4789"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16033">
        <property type="entry name" value="DUF4789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4789" evidence="1">
        <location>
            <begin position="172"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="351" mass="39151" checksum="7CBB8970A5D1F3D4" modified="2011-04-05" version="1">MAALGLSLDSDDNNVNAIGPANTAPNPYSDYEDLLFDEYDQPLQDNKLLAETASPTSNKFLKSEVCGRKFFCQRGNRGPCHRNEVFLPQLNDSSIFTRPSCGNMVSYPWNGCMSAGKVGVAANNAAVGGGCAVRFPQRPCYGYPPNYRFYTETKRCYPVSVGWEGGMSNSGPCPLNKVFTDIDGINGMCQCRDRNQLLFKGDDRCHRIYAKGPCDHGNWLEPDTNGYGMCNRSPCPESKCDGRHIYWKSTPNSEGGCYKSFTRGPCRSGSYFLVEDYGTRRGRCVSQYGSSFNPMSPYAIPPRYPVMRNPYDMMYSNNMLSPWAKIGMYPPFGGQQDYGGEDYDDISNLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9G984</accession>
    <name>E9G984_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_315263</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84131">
        <property type="protein sequence ID" value="EFX84131"/>
        <property type="gene ID" value="DAPPUDRAFT_315263"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315263"/>
    <dbReference type="HOGENOM" id="CLU_1847121_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="139" mass="15624" checksum="34EF1462E7B33498" modified="2011-04-05" version="1">MVDKSSNAEAAHLWKALSEDEIKSLIEVIDEFGKLVHPSKCEVPLMDLVVIIFKEIVIVVVVGTMLLAETLKMTSCGQTNFDAERLGNHAVDHVEKLSTILIKGTQAIQSRASIKSCRLHGSHIYRCREHHEDILYLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9V0</accession>
    <name>E9G9V0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_239688</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83819">
        <property type="protein sequence ID" value="EFX83819"/>
        <property type="gene ID" value="DAPPUDRAFT_239688"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_239688"/>
    <dbReference type="HOGENOM" id="CLU_877881_0_0_1"/>
    <dbReference type="OrthoDB" id="1298431at2759"/>
    <dbReference type="PhylomeDB" id="E9G9V0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045717">
        <property type="entry name" value="CHRDL1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46303">
        <property type="entry name" value="PTHR46303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="3">
        <location>
            <begin position="122"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX83819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="317" mass="34070" checksum="34C00BC64C1E9F99" modified="2011-04-05" version="1">MGKHNTRYHSTRSRQSSTDRHRLRTSQRNGTEPKSETIQSSSSSRMTAASANSAIMGRQQQQQQGRMMTTTTLTAAVPTILLLLSTFSSLMAAERGSSQVSSLVVHAGARSTVMAADVSDGTTCTFTSRNYAVGDVWYPRLGQRGALHCVACICQEGGKINCTIHECGGQDCASPESAATNECCVHCSKEATKSTTTLTAASTRPAPFYPEEVPVSSFSSSDLSGSSTSSGVTCLHNGNVYRHKERFTSSNVGLKPEHADQCVQCSCEGASTTSHLSQRETTRRPPRLFVYSFSLTSLAGRGRLLVALEYSNVRTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9GA18</accession>
    <name>E9GA18_DAPPU</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_315544</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83787">
        <property type="protein sequence ID" value="EFX83787"/>
        <property type="gene ID" value="DAPPUDRAFT_315544"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_315544"/>
    <dbReference type="HOGENOM" id="CLU_075165_4_1_1"/>
    <dbReference type="InParanoid" id="E9GA18"/>
    <dbReference type="OrthoDB" id="1583175at2759"/>
    <dbReference type="PhylomeDB" id="E9GA18"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012610028" evidence="3">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX83787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="112" mass="12343" checksum="D9B388F76F58A970" modified="2011-04-05" version="1">MKFLIFAALIAVAMAAYEPTAKAVEEAAPAEPVPQPYSFGYGVKDEETYNDFDHAENADGEVVTGSYRVALPDGRTQIVTYRADKNGYTADVKYEGEAQYPEYVEPALKTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9GCE0</accession>
    <name>E9GCE0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_48610</name>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732539">
        <property type="protein sequence ID" value="EFX82871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_48610"/>
    <dbReference type="eggNOG" id="ENOG502QU73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046048_4_0_1"/>
    <dbReference type="InParanoid" id="E9GCE0"/>
    <dbReference type="OMA" id="FICEVTA"/>
    <dbReference type="OrthoDB" id="753787at2759"/>
    <dbReference type="PhylomeDB" id="E9GCE0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="112"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX82871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="158" mass="17907" checksum="9A49645A06F4A99D" modified="2011-04-05" version="1" fragment="single">VVVPSEVAAGRDALLQCHYDLEGSSLYALKWYKGSHEFYRFILKEVPPVQTFPWSSITIHHATPLAGRVLLRNVTAAAEGVYKCEVSTEAPYFDTDYEEANLSVVEVTSENPIISWLQGRLDWEYDDVFHFKCSMNGTRPASQLSWLLNGQPVNIRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GE39</accession>
    <name>E9GE39_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_302626</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82383">
        <property type="protein sequence ID" value="EFX82383"/>
        <property type="gene ID" value="DAPPUDRAFT_302626"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302626"/>
    <dbReference type="HOGENOM" id="CLU_033941_0_0_1"/>
    <dbReference type="InParanoid" id="E9GE39"/>
    <dbReference type="OrthoDB" id="489543at2759"/>
    <dbReference type="PhylomeDB" id="E9GE39"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX82383.1"/>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_102493"/>
    </dbReference>
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    </dbReference>
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            <end position="50"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX81469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="109" mass="12141" checksum="3C77FBC478EC0410" modified="2011-04-05" version="1">MNRDVDAILPDSDVASEVTLDSSSDLGRSSPTLRGIRVRDANSKQRTRRPFHLQSTIAANRAESPVLIDAVPYDNAQEATYSRYKYYQRLRGPTIGNDQALVQTLGLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name type="scientific">Daphnia pulex</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732543">
        <property type="protein sequence ID" value="EFX81422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_196289"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_196289"/>
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    <dbReference type="PhylomeDB" id="E9GGN3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
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    </dbReference>
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    </dbReference>
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            <end position="396"/>
        </location>
    </feature>
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            <begin position="518"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    </evidence>
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            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX81422.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="627" mass="69125" checksum="56369A6D80D768CD" modified="2011-04-05" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5003237094" evidence="1">
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="106" mass="12179" checksum="BE9D36EA9FBCA7D2" modified="2011-04-05" version="1" fragment="single">MHIFFYVIHVTAMLAIVSGNCNKYGNACFGAHGKRSDFKRTSAVDLSDQIWPVAANWNPTRPDEPIQERRQMKPLPALQLESVLVYNDIPRSAEHSRYLNQEDYNN</sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Dong Q."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Rough endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732550">
        <property type="protein sequence ID" value="EFX79880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79880"/>
    <dbReference type="EnsemblMetazoa" id="EFX79880">
        <property type="protein sequence ID" value="EFX79880"/>
        <property type="gene ID" value="DAPPUDRAFT_304356"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304356"/>
    <dbReference type="eggNOG" id="KOG2357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033196_0_0_1"/>
    <dbReference type="InParanoid" id="E9GKZ9"/>
    <dbReference type="OMA" id="PPIDQKV"/>
    <dbReference type="OrthoDB" id="1337297at2759"/>
    <dbReference type="PhylomeDB" id="E9GKZ9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="PTHR12883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="DUF1682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241304" evidence="7">
        <location>
            <begin position="19"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX79880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="335" mass="38593" checksum="2F9203F8043AD0CC" modified="2011-04-05" version="1">MILAGLVLYFFNFFLGRSKNQRIAETWYSAFKGPLLEKFALVGDDGKLENSQPGLMKESENVYLLWCSGRTGCEAVLFELRLLKRQDLVAMVMNLFRPQQDQVHVKVFMNDSDMDSFVMCLAAKKTATRLIREMADISVYCPEKKSAVEKFGLPTNFVLMSEIGEASTTLLDARVCSLINNIPEVIESIHFSDQYSGPKQTEDTAPSKMPEVKKMLIFNFNLPLKNGKSIVEAVEIIRPAIMLTFYCIDRVKRFRLSKEFKSKAEKNRQKVEEAFLKSTHAARAEAAAARREEKRRLEKEKILQDDDPEKQRKWEEKENKRLAKKRMPKMKAIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9GNA4</accession>
    <name>E9GNA4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Yolk-protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_245406</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732554">
        <property type="protein sequence ID" value="EFX79066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79066"/>
    <dbReference type="EnsemblMetazoa" id="EFX79066">
        <property type="protein sequence ID" value="EFX79066"/>
        <property type="gene ID" value="DAPPUDRAFT_245406"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_245406"/>
    <dbReference type="eggNOG" id="ENOG502QVV6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027171_2_0_1"/>
    <dbReference type="InParanoid" id="E9GNA4"/>
    <dbReference type="OMA" id="MVGIRGE"/>
    <dbReference type="OrthoDB" id="930723at2759"/>
    <dbReference type="PhylomeDB" id="E9GNA4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="PTHR11610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="11"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX79066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="285" mass="31202" checksum="E66ED1040995898D" modified="2011-04-05" version="1">MPNLSNPNFGLQLPINQPDVLNWSTFNRLRPVKVLIHGFGGNGTTDRFVSKARDAYLLLGDFNVITVDWRSLAEYPNYARAALSTTPVGIYVAKFLDFLISQGTSSSLLHVIGYSLGAHVAGSVGNCLRLGRLPRITGLEPASGGYERIEKLRSLSSSDADFVDVIHTNAHVLGLGTTTPIGHADFYPNGGHWQYGCLWNTEYDSLIHCSHGRSTHYFIESILAGPTKFLSSRCPSYLKFNLGICGGCQDPLDRHNCVSMGEFANPTASGTYYLYTNPTSPYSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9GRF0</accession>
    <name>E9GRF0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_320916</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732559">
        <property type="protein sequence ID" value="EFX78002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78002"/>
    <dbReference type="EnsemblMetazoa" id="EFX78002">
        <property type="protein sequence ID" value="EFX78002"/>
        <property type="gene ID" value="DAPPUDRAFT_320916"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_320916"/>
    <dbReference type="eggNOG" id="KOG0613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_406674_0_0_1"/>
    <dbReference type="InParanoid" id="E9GRF0"/>
    <dbReference type="OrthoDB" id="1615984at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX78002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="676" mass="74265" checksum="6B46A755CDC17FF3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9GRP5</accession>
    <name>E9GRP5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_247057</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732560">
        <property type="protein sequence ID" value="EFX77805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77805">
        <property type="protein sequence ID" value="EFX77805"/>
        <property type="gene ID" value="DAPPUDRAFT_247057"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_247057"/>
    <dbReference type="HOGENOM" id="CLU_1429340_0_0_1"/>
    <dbReference type="InParanoid" id="E9GRP5"/>
    <dbReference type="OrthoDB" id="724521at2759"/>
    <dbReference type="PhylomeDB" id="E9GRP5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="218" mass="24437" checksum="E8A4463AA6D12456" modified="2011-04-05" version="1">MMLRHFKEEFIIKNSVNGGAPLSRWKLRDDAIPTLVLGYKDGVAPNKKYRKKTTSPLSNNGCHNQPEEKIDARTTSDGKSAEVTLAGESSLEHKTPETGVENLVETQHEENITSDTSVETQREENITSVETQHEENITSDTSVGKHTEDTAEVITAMDCDDSTIIETIENIICDPSDAKLPPSWRWLPDCDVYNEDDPTAFKKIAVRFGQKHSWKTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9GSR6</accession>
    <name>E9GSR6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_247582</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732562">
        <property type="protein sequence ID" value="EFX77534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77534">
        <property type="protein sequence ID" value="EFX77534"/>
        <property type="gene ID" value="DAPPUDRAFT_247582"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_247582"/>
    <dbReference type="HOGENOM" id="CLU_919074_0_0_1"/>
    <dbReference type="OrthoDB" id="1785179at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="SSF49842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="2">
        <location>
            <begin position="171"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX77534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="303" mass="32859" checksum="17E9E158C53F09CD" modified="2011-04-05" version="1">MTFMENRHEESVEAQTALKHYSNLSSVFPGKMAFVTSKVRLYLLCASVELLISLLLSSMTVATCLGDGKQQWDSKSVWDSTTPTYLATEMIVTRQILVSPRKPQHLDEMVTAHRQIDGPNDGIATEKQPNLNFASRKMIGLANLTSNASLIESNKKPIVALPNMMLGTDPSKKSHIIFSAYTEHPTPKNSSVTYTKTNATDGNPVDAPSGVYTALKPGLYGFIFHALTNDLNHVLPTVELRVNGGAAATAAAFNGGTYKALTLIAGARLNRGDHVSVFVVDGPLFHRKKGSNHRASFAGTLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GU53</accession>
    <name>E9GU53_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_248310</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732565">
        <property type="protein sequence ID" value="EFX77034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77034">
        <property type="protein sequence ID" value="EFX77034"/>
        <property type="gene ID" value="DAPPUDRAFT_248310"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_248310"/>
    <dbReference type="HOGENOM" id="CLU_2656990_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX77034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="76" mass="8781" checksum="2D5EB02E138E119A" modified="2011-04-05" version="1">MTMGAQIEELNLIQIREIIPFDWSKSAPFLESHLCPHVGVFTRTPFCLSCLAYSTLLHGWMKHVDAWPYFPGLKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9GUD9</accession>
    <name>E9GUD9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_106728</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
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        <source>
            <dbReference type="EMBL" id="EFX75287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="211" mass="24006" checksum="8081A46A18536B95" modified="2011-04-05" version="1" fragment="single">EHRRVCHINAEQKRRCNIKNGFDTLHGAAASSHGKASDVSKAAMLHRGAEYIRQLRQERQQQQEEMDQLKQNIETLNAAISGCQALLPANGAPVSRQRNNRMREMFDEWVRVRTLQNWKFWIFSILIQPLLESYSTALSAATYEDLWQSVLNWVDQYCSLIALRPVVFNSLRNLSKTTDIIANPSRLPAEATQAACNPDRTTTPNNLPSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZW9</accession>
    <name>E9GZW9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_56528</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="GL732579">
        <property type="protein sequence ID" value="EFX74890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74890"/>
    <dbReference type="EnsemblMetazoa" id="EFX74890">
        <property type="protein sequence ID" value="EFX74890"/>
        <property type="gene ID" value="DAPPUDRAFT_56528"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_56528"/>
    <dbReference type="eggNOG" id="KOG0262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2608464_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb1_4" evidence="7">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX74890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="79" mass="8465" checksum="E31186FC4BCB5799" modified="2011-04-05" version="1">MKTRACIPGGLHKLFPDNNLALMIQSGAKGSSVNAMQISCLLGQIELEGKRPPLMISGRLFIEIGQQPCTLDLPCTLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZX9</accession>
    <name>E9GZX9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_251211</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732579">
        <property type="protein sequence ID" value="EFX74896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX74896">
        <property type="protein sequence ID" value="EFX74896"/>
        <property type="gene ID" value="DAPPUDRAFT_251211"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_251211"/>
    <dbReference type="HOGENOM" id="CLU_3126482_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GZX9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD" evidence="1">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX74896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="50" mass="5693" checksum="BDCEB8E00BA98F7B" modified="2011-04-05" version="1">MTAEENDSGYPKQVKIIESTMSKRDCMVVMPTSDGKSACFLIPVYERQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9H190</accession>
    <name>E9H190_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_324374</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="domain">
        <text evidence="4">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732583">
        <property type="protein sequence ID" value="EFX74401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74401"/>
    <dbReference type="EnsemblMetazoa" id="EFX74401">
        <property type="protein sequence ID" value="EFX74401"/>
        <property type="gene ID" value="DAPPUDRAFT_324374"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_324374"/>
    <dbReference type="eggNOG" id="KOG0819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025300_0_0_1"/>
    <dbReference type="InParanoid" id="E9H190"/>
    <dbReference type="OrthoDB" id="856254at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="match status" value="4"/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732590">
        <property type="protein sequence ID" value="EFX73454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73454">
        <property type="protein sequence ID" value="EFX73454"/>
        <property type="gene ID" value="DAPPUDRAFT_253085"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_253085"/>
    <dbReference type="HOGENOM" id="CLU_1262694_0_0_1"/>
    <dbReference type="OrthoDB" id="222689at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX73454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="219" mass="24201" checksum="FCAD783B8FD2BD0C" modified="2011-04-05" version="1">MYPKLQLCNKPIIAHLPASITFDPAIPIQTHSPTESTSKPILAVVNDSQRYTNLHDDNKTFLQMLKLKKPIRLQLLDAGRNTKFIREGFSRSLLDLGLTQTLRTDGVAEATSTHTNSEETELQLKKAFGDTVTLKDSTMKNVTQPAPVFVWDKLLSWNHLVDFPPLRSSGGRIAMLIGLNQTALITSTDYRMGADNELVAITTNLGRTIQGVLGLAFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9H5S5</accession>
    <name>E9H5S5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_58283</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus</location>
            <location evidence="1 11">Golgi stack membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="GL732594">
        <property type="protein sequence ID" value="EFX72919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72919"/>
    <dbReference type="EnsemblMetazoa" id="EFX72919">
        <property type="protein sequence ID" value="EFX72919"/>
        <property type="gene ID" value="DAPPUDRAFT_58283"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_58283"/>
    <dbReference type="eggNOG" id="KOG2619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032075_3_0_1"/>
    <dbReference type="InParanoid" id="E9H5S5"/>
    <dbReference type="OMA" id="NAKDCRY"/>
    <dbReference type="OrthoDB" id="551308at2759"/>
    <dbReference type="PhylomeDB" id="E9H5S5"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036065">
        <property type="term" value="P:fucosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="PTHR11929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glyco_tran_10_N" evidence="12">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX72919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="311" mass="36590" checksum="30C25965E7721533" modified="2011-04-05" version="1" fragment="single">CPVWQCETSTNRTDVHDYDAVIFHMRGSWNPNDLPHRRSPQQRYVFWILESAEWREYLNTSTLGNFFNWTLTYRWDSDMIMPYGYVRPTGNVPLHPSENQLKQLMSNQKVNYAAGKAKMASWMVSSCFSHSSRHEMVKILQKYIQVDIYGACGTKTCPKKEDENNSSEECRDVAGGNYKFYMALENSLCHEYISEKFFGMLHRPIIPVVFGLHDHYDKIAPPHSYINAAKFENMRQLADYLILLDRNDTLYNEYFWWKPHFESRYKQKDVNIGMCHLCASLHNKDLPPKVYPNMTDWWESKSSCISTPLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6M4</accession>
    <name>E9H6M4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_254242</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732598">
        <property type="protein sequence ID" value="EFX72534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX72534">
        <property type="protein sequence ID" value="EFX72534"/>
        <property type="gene ID" value="DAPPUDRAFT_254242"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_254242"/>
    <dbReference type="HOGENOM" id="CLU_1549219_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9H6M4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241559" evidence="2">
        <location>
            <begin position="22"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX72534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="187" mass="20404" checksum="27DC8DE9BCA827B6" modified="2011-04-05" version="1">MESAASAVIVFLVCMMASANAGRPQHPFMHKPRPLASNSNVNINTNTNDNTNYNLISSLLSQLTGNEEQNDCVYGDFSCFEKMLGAKGAKGLAKEKPETTPENEDNDVPEEDNTEILGLEKASADVNSKRRPHRPTRPSRTSNYNLNSNSNTNSNNDLSSILASLEQFLDMDIKKRAAKAAPVNSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9H7I9</accession>
    <name>E9H7I9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_254645</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
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                <person name="Andrews J."/>
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                <person name="Zdobnov E.M."/>
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                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732608">
        <property type="protein sequence ID" value="EFX71628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71628">
        <property type="protein sequence ID" value="EFX71628"/>
        <property type="gene ID" value="DAPPUDRAFT_255583"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_255583"/>
    <dbReference type="eggNOG" id="ENOG502QTFM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007156_0_0_1"/>
    <dbReference type="InParanoid" id="E9H9J6"/>
    <dbReference type="OrthoDB" id="294726at2759"/>
    <dbReference type="PhylomeDB" id="E9H9J6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="PTHR10237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="940"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX71628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="981" mass="112542" checksum="54522359232915D8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9HAJ7</accession>
    <name>E9HAJ7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sepiapterin reductase</fullName>
            <ecNumber evidence="2">1.1.1.153</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_309138</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sepiapterin reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.153" evidence="2"/>
    <dbReference type="EMBL" id="GL732612">
        <property type="protein sequence ID" value="EFX71194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71194"/>
    <dbReference type="EnsemblMetazoa" id="EFX71194">
        <property type="protein sequence ID" value="EFX71194"/>
        <property type="gene ID" value="DAPPUDRAFT_309138"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309138"/>
    <dbReference type="eggNOG" id="KOG1204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_11_1"/>
    <dbReference type="InParanoid" id="E9HAJ7"/>
    <dbReference type="OMA" id="PYKGWSA"/>
    <dbReference type="OrthoDB" id="1089743at2759"/>
    <dbReference type="PhylomeDB" id="E9HAJ7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004757">
        <property type="term" value="F:sepiapterin reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006393">
        <property type="entry name" value="Sepiapterin_red"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01500">
        <property type="entry name" value="sepiapter_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX71194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="262" mass="28332" checksum="EF68CA6418AFEF98" modified="2011-04-05" version="1">MDESCYWNQKTFAIVTGASRGIGRTLAEKISKQMGADSVLLLISRDEKDLDSLQKAIETDRPSVRVHVGVTDLSSCDESALNGVVSSALAGESAESFAHALCVHNAGSLGDATKRCTDLVSVNSCVQYFQLNLASVVVLNAIFLRRFASSLSPVQQRKTVVNMSSLCGVEPFSSLSLYCTGKAGRDMFFKVLAKEEPDVRVLNYAPGPVETNMRTQLLHQSWTEEIKSGGLGLTTEMTCDRLMAILAGDSYASGAHVDYYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9HAS7</accession>
    <name>E9HAS7_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_231560</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732613">
        <property type="protein sequence ID" value="EFX71081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71081"/>
    <dbReference type="EnsemblMetazoa" id="EFX71081">
        <property type="protein sequence ID" value="EFX71081"/>
        <property type="gene ID" value="DAPPUDRAFT_231560"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_231560"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_7_0_1"/>
    <dbReference type="InParanoid" id="E9HAS7"/>
    <dbReference type="OrthoDB" id="1727719at2759"/>
    <dbReference type="PhylomeDB" id="E9HAS7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003238230" description="Peptidase S1 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="26"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX71081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="293" mass="31066" checksum="631522C1BFE2DB9A" modified="2011-04-05" version="1">MKSVLLLVAVVCSVTGLPALYDNGRIFGGGTATSAQFPYVVSITENDRHFCGGFIYSARWIITTASCVAGKTASKLKVVVGQVSAITADPNEQTLTVYTITPVPQYNSTNKFNDIALLKLSADIDFDYVNVDFVAYNELVNNLPAVVMGWGSTFEGGLESVNLHYGEVTLNLATSTSACGSYVADVDFNFATMICASNNPEAATLVAPPTATESPLGSPCSYDEGSPLVQVMDKVPTVVGILSKTDGCSTESYGVYTRVSIFYSWLLNTAGPQPIRPTTPAPTTTTTDITGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9HC57</accession>
    <name>E9HC57_DAPPU</name>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003241133" evidence="1">
        <location>
            <begin position="28"/>
            <end position="315"/>
        </location>
    </feature>
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            <begin position="165"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX69011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="315" mass="34937" checksum="A10B646FE7B33076" modified="2011-04-05" version="1">MAHFSVASLSQVVFLLVFICWTSSTGAAFSMEEDFLQLKDNYIQMKQVVKSLEAKVEELKGLESTTIELQAKVEQQDSLLTSLLREKNERTAAANDFDSVPIGNNPSAVAINGLPSSCGDLKMIGHIWSGFYSVMGSAMMESVYCDFTKLPSDAGFQKWIGYADVKSAPVHFYVQRNSNFFSENTSIPFDLALVNEGNAMNLTSGIFTAPRPGIYFFSFTGSARLSSSSSYVGFYSYLYLNGDIIGTGRVSEYNGPVNQYSPFTLQSTLNLKKGDQLWLGISYSTDSYSYLYDGRDDHRTHFTGFMLEEEIVASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HJX3</accession>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX67966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_260793"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_260793"/>
    <dbReference type="HOGENOM" id="CLU_2111299_0_0_1"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="115" mass="12867" checksum="371725C0B10208B4" modified="2011-04-05" version="1">MGLTATELKDADIIIGKLQERCNAGRNCHVWRQKFSSRVFDDVVRRKLLERGAYLTLDRALTTLRTAEATRLQASTIKQSGAAPVHQLKTPAAKPHMGKPAIQHRDQQRGRPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKK0</accession>
    <name>E9HKK0_DAPPU</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX67746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330757"/>
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    <dbReference type="PhylomeDB" id="E9HKK0"/>
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    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX67746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="161" mass="18528" checksum="CFF80484AEA43C40" modified="2011-04-05" version="1">MSSTQHKGCDLRSEEQKARVKKYNDSRRKEMKSFGLFASGANNSGDGSKQNSSELVIARSRTNKRKRDESFSWWPDIHDQPADSFDVEPDFNQTVPQFLQSALKNFSLLEKKTGLIAVAKSRKRKRNECFSLFSETRGQPVDLFDVSRDAWFTMARIKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
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    <name>E9HR35_DAPPU</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732730">
        <property type="protein sequence ID" value="EFX65803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX65803">
        <property type="protein sequence ID" value="EFX65803"/>
        <property type="gene ID" value="DAPPUDRAFT_332841"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_332841"/>
    <dbReference type="HOGENOM" id="CLU_2851927_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HR35"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX65803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="65" mass="7552" checksum="432766AD3CF29309" modified="2011-04-05" version="1">MSDSRLLAEKVESDNPPMESVKVFPIQSTSQELTKELENLKFRYNNLKSQNAKDVCELEELSTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9HRX8</accession>
    <name>E9HRX8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_333124</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Dong Q."/>
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                <person name="Manak J.R."/>
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    </evidence>
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</entry>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_118064</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732812">
        <property type="protein sequence ID" value="EFX64577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX64577">
        <property type="protein sequence ID" value="EFX64577"/>
        <property type="gene ID" value="DAPPUDRAFT_118064"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_118064"/>
    <dbReference type="HOGENOM" id="CLU_019281_1_3_1"/>
    <dbReference type="OrthoDB" id="1594142at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PTHR45636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX64577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="196" mass="19916" checksum="BA24371E33CD021A" modified="2011-04-05" version="1" fragment="single">RCWPDRTGGGNFLFPQSANTGGVASSAFNTAESFGQLFATAAAATPSGGLSNYTPTSSSASFAGVEYPSHPHHHLPGALGETGWNTVKSGGGGGGSAGNSIGTEMPSWTTAPASFNGFDNYNGLATGEMFMGHHHHHHHHQSYADVGKAASASFSYGHHHNPAVVGVSSAAAAAVAYRNYNLAKGNSAAAASFGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9HUQ2</accession>
    <name>E9HUQ2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Pyruvate kinase</fullName>
            <ecNumber evidence="5 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DAPPUDRAFT_334106</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 13"/>
    <dbReference type="EMBL" id="GL732818">
        <property type="protein sequence ID" value="EFX64530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX64530"/>
    <dbReference type="EnsemblMetazoa" id="EFX64530">
        <property type="protein sequence ID" value="EFX64530"/>
        <property type="gene ID" value="DAPPUDRAFT_334106"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_334106"/>
    <dbReference type="eggNOG" id="KOG2323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_1_1"/>
    <dbReference type="InParanoid" id="E9HUQ2"/>
    <dbReference type="OMA" id="QVPIVQK"/>
    <dbReference type="OrthoDB" id="933620at2759"/>
    <dbReference type="PhylomeDB" id="E9HUQ2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="14">
        <location>
            <begin position="50"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="15">
        <location>
            <begin position="417"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFX64530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="539" mass="58357" checksum="A223E3A7A824294A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9HW94</accession>
    <name>E9HW94_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_267284</name>
    </gene>
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                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733317">
        <property type="protein sequence ID" value="EFX62901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX62901"/>
        <property type="gene ID" value="DAPPUDRAFT_269480"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_269480"/>
    <dbReference type="HOGENOM" id="CLU_2457032_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026937">
        <property type="entry name" value="SBNO_Helicase_C_dom"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase_C_4" evidence="1">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX62901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="105" mass="11936" checksum="1079470C5C64A10D" modified="2011-04-05" version="1">MQPKPKSIDIAHKKRFLQLYFQISYESCSKPGLSIEDVNIPEKENFMNGQKYAVILSAASQEGISLHYTRPLVSALENVLFQTKLAEKRRFRVGCCKSSGEYAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9HZX2</accession>
    <name>E9HZX2_DAPPU</name>
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        </recommendedName>
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    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_336563</name>
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    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX62708">
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        <property type="gene ID" value="DAPPUDRAFT_336563"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1209603at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:arachidonic acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:fatty acid metabolic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
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        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="236"/>
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        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
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            <end position="245"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
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            <begin position="272"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX62708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="349" mass="39346" checksum="670C23AFC456016D" modified="2011-04-05" version="1">MKVGQSSEIFGSLQKRVFLRKPLERCQPYSFHNRLKVQKRGSSSHTNNNGEIVTAKGQTISLNKDSTTRVTSQFKTITTLFVELVKTNTPSFDLSLSSLAKRLPFQNVQTDIPKDNIANKKLEEKMGLRLRLVFHHTLISWEGRKKKRKKLQSLNGKSSARLLAKRVLLVRLEDFCHHLFQYPAAKSVASREGAISILLRLKHSIPRDELIQRQIREGLALLGYADPLPAKGIRILSIDGGGTRGLLALRILRHLEKISGKPIYESFDYICGVSTGAVLALLIGAAKKNVKDVETMYREISTEVFKQDRSSGLGGLLWSHAYYDTKFKLQTCRPVCMSFTLEGHGEHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9I153</accession>
    <name>E9I153_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX62277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62277">
        <property type="protein sequence ID" value="EFX62277"/>
        <property type="gene ID" value="DAPPUDRAFT_301679"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301679"/>
    <dbReference type="eggNOG" id="KOG1987">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_004253_9_3_1"/>
    <dbReference type="InParanoid" id="E9I153"/>
    <dbReference type="OrthoDB" id="864323at2759"/>
    <dbReference type="PhylomeDB" id="E9I153"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase binding"/>
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    </dbReference>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX62277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="134" mass="15659" checksum="7B6B01F7CEE3F907" modified="2011-04-05" version="1">MFYHNLQESERGKVFVQDIRPQIFKEMLHYIYSGQTLAPLTDAITQPLFVVSDKYDIEDLKEKCVRYLLRSVRKSNAVDLLVWANLHSLEKIQEAALDFVAGNFKTICHSNEWENLMKNYPELGFLVTQRYAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9I1C4</accession>
    <name>E9I1C4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_337271</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:positive regulation of voltage-gated calcium channel activity"/>
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    </dbReference>
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        <property type="term" value="P:skeletal muscle contraction"/>
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        <property type="project" value="GO_Central"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="138" mass="14645" checksum="DC07DA0DB34F5BE8" modified="2011-04-05" version="1" fragment="single">MNVSLAGAEGSSSKRYNALANQCRAVNPSTDLATFVRSVVGGSGSGPGGGGGSVLTIPSSFNKFTFIPPRNPPPGSVSCSQHDIQDASLVLKDELVFDRLAGFSLRTKYDSLKKDTAEVEAHVRQLNECMESLTRLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2G8</accession>
    <name>E9I2G8_DAPPU</name>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734092">
        <property type="protein sequence ID" value="EFX61812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX61812"/>
        <property type="gene ID" value="DAPPUDRAFT_338047"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502RTC7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9I2G8"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="P:DNA duplex unwinding"/>
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    </dbReference>
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            <begin position="49"/>
            <end position="87"/>
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            <begin position="49"/>
            <end position="81"/>
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        <location>
            <position position="428"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="428" mass="49492" checksum="FEF9FE27586BEF5C" modified="2011-04-05" version="1" fragment="single">MAVINCNNCTKYVRDQKVSMYYGAYTTKHSTDCEKALAEAMLAIEKHENKVRKQQQQADNENERYQREREMEEDNMEEPQLPTPRRSDYSIGLGKLLSAVRASTNGDTIGGPLAACALLGNNIFAMSHQTAPLPLTQAIGYLEKQNINATFTRFGEVKATIHDYVFRSNRNQDIEDMNYWTFIKTQESCKLAPQKRRDSDNDNDNVDELEPGLTREIHRFSSSHPQHATQGHRARTNVHWTKYLAKRLPDQDDLEDNSNLTTEEREQRREEYAKGVLIMFLPFREKTDLVNEGETWWNAYQRQKKMLYSNQDTKTTIDSIQNFYESFCRPSSESQALDFTEKDLQQMAEEENETIDTNEEEIDIIDIDQELEKTADEPLEELTKDPFIAKLASLPENPMDIPTRQWTSTINHNDALQAIRQLPSKSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2H7</accession>
    <name>E9I2H7_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DAPPUDRAFT_271798</name>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_271798"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1526721_0_0_1"/>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="176" mass="19509" checksum="D3F569B23E351E3C" modified="2011-04-05" version="1">MGDIPSSPSSSESTKRRRALRSMSGDTLTVDLGENSVNTPELPPGIPNSTDSHGAKKNKKKRRRSRDSSPSDSGSGSSSSSRSPDRKKPRKDGTDSGGFDEPSNVAMLPRSRVRDLRRWMKEGIESKTEGNTLRSAYVPKFEGDFELMAPLLDPSMARKWLRNLECDILRRVSQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
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    <name>E9I2T7_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX61693"/>
        <property type="gene ID" value="DAPPUDRAFT_121154"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_085492_0_0_1"/>
    <dbReference type="OMA" id="CQARCLC"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="284" mass="29682" checksum="A908DC4A5D592E01" modified="2011-04-05" version="1">MVKIPDQFGVYSFDFGHSTPNRNPVKVRFRNLCSPWLPNVSDQQPASAAASQCSSQPVQQPASAAASQCSSQPVQQPASAALSQCSSQPVQQPASAAASQCSSQPVQQPASAAASQCSSQPVQQPASAAASQCSSQPVQQPASAAASQCSSQPVQQPASAAASQCSSQPVQQPASAAASQCSSQPVQQPASAAASQCSSQPVQQPASAASLIYIDSPPVLMEFFPIQRKSFLISLKQQSLTFGYRRSLFGVIAPFSTTTVIIDFPLSVDFLRIQHCEYLHIVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2W2</accession>
    <name>E9I2W2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_272283</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61668.1"/>
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    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61668">
        <property type="protein sequence ID" value="EFX61668"/>
        <property type="gene ID" value="DAPPUDRAFT_272283"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_272283"/>
    <dbReference type="HOGENOM" id="CLU_774480_0_0_1"/>
    <dbReference type="InParanoid" id="E9I2W2"/>
    <dbReference type="OMA" id="PASYVCI"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="358" mass="37852" checksum="5C49B610FAA16489" modified="2011-04-05" version="1">MQTTQQPQAAAPNRRRLVSALERAIQTSFKAIQPRKQLAISRRFQPVILRLHPAFSRRFQPAFSPPYAFSQPSGYAFSQPSGYAFSQPASYVCIQLSADASSQPSAYVCIQLSADASSQPSAYVCIQLSAYASSQPSAHVCIQLSAYASSQSSGRAYAFNQPSGYAFSQPASYVCIQLSAGASSQPSAYVCIQLSADASSQPSAYVCIQLSAYASSQPSAHVCISALSLRFQPVIRPRQLPAYAFNQPSGYAFSQPASYVCIQLSAGASSQPSAYVCIQLSADASSQASAYVCIQLSAYASSQLSADVCIQLSADASSQPSAYVCIQLSAYASSQPSAHVCIQLSAYASSQSSGRGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9I376</accession>
    <name>E9I376_DAPPU</name>
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            <fullName evidence="2">HPt domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734407">
        <property type="protein sequence ID" value="EFX61554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61554">
        <property type="protein sequence ID" value="EFX61554"/>
        <property type="gene ID" value="DAPPUDRAFT_338993"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_338993"/>
    <dbReference type="HOGENOM" id="CLU_154811_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF47226"/>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="HPt" evidence="2">
        <location>
            <begin position="38"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX61554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="137" mass="14890" checksum="76141DE73DD06823" modified="2011-04-05" version="1">MSTPTPPPTHSNQPPAAARPCLDPIALERLRELDPSGQNKLIERVLAAYLKSLDRLLPELAQARGEQLDLQVVRHVSHTLKSSSASLGALDLAERCAEIETRARNQQAEGMEALLDAMLDDIQQVRLALTALAPTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9I4D7</accession>
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    <protein>
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    </gene>
    <organism evidence="2">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734998">
        <property type="protein sequence ID" value="EFX61143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61143">
        <property type="protein sequence ID" value="EFX61143"/>
        <property type="gene ID" value="DAPPUDRAFT_340571"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_340571"/>
    <dbReference type="HOGENOM" id="CLU_2608457_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9I4D7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="79" mass="8375" checksum="8DFEF316C236D337" modified="2011-04-05" version="1">MAREKTTELSRVSISDTAITAAQYVSSTTFFIALPVRNHGLVNYGAVLLFVVESLIVGSTTGVQMPPGHCGYQATAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9I5E7</accession>
    <name>E9I5E7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_275510</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Yamagata H."/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="262" mass="28526" checksum="D2D527A864FA8387" modified="2011-04-05" version="1">MVMAFSGRKSRQNLQVPQPVGSLQIHWLDLIDVPFVSFPFRNPRGVATFGASTGNPNPGTAAITTWSALLLAIEGEVAELNNRLIPLSIRRRRESPAWQDPFEFADSSGSRLNWPAGSFRPSHPDHCIGRSRQIVRESPPLSFPSNLSGSLAGQLEFPFAVGRFYLSASLSSVKATADRPYRSSVPVSQFVRLIRPSAGTFIFNPPVQLIDPATGISVCNGPALLTSQFYHPFQPVLLGPTDISVHHPNPVLPASSLRVNLP</sequence>
</entry>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1286110_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
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        </location>
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            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX60782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="215" mass="24335" checksum="B175BB2C589E3D48" modified="2011-04-05" version="1" fragment="single">TVVKLFRVDIAIKRFIRFHHHVHRMFSSQICLLKLLKSSSLSVIHSKCRSTKRSIQEGFFRLSRLPQNLPSWRFYIPKMKNRIVNPMEIPGDSFSIKKIPGKKTKLDPSGDKQTPRGPKGNKNTKTMKINKKPRMMKKSDGKKTQSNNESSGSLARAITYGCATHMAEDSLGDGVVLMGPLRTCLLQTLFRPLELLPILSASSGDNLNLMKNDER</sequence>
</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="VFRINRY"/>
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        </location>
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        </location>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="185" mass="21345" checksum="377DEE483789272F" modified="2011-04-05" version="1" fragment="single">MATIRQAIARRPVYKPSIRSTWGLACSRKFNDDAWGAPAPTQGGSRATAALNGRRIKLVEDKDSGRRGSRRRSRSRSSSRSRSRSRRRSRRRSRSRSRSRSRSRSRSRSRSRNKSRSRSKRSGRKSRRRSKSRGHSKSKSKSRLRSPRKSRSKSRSRDKSVDRDRSVSRDKSVERAASKQSRSNS</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="345" mass="35749" checksum="FD6B8D76C0766B26" modified="2011-04-05" version="1" fragment="single">QASSTRIIYKKAELIAAGIKPGIIKSIAFNISNVVNSSFSSYEVRIGATTSINAITANAPMFTIFGPAPLVVAGGWHTSTKYPITRGFDWDGNSNIIIETHAVTTLPVGSSNQMLTMTSIAGNEVAYKYSDTIGLSAENSAKGYTGAGASAAKPQLQVEFCTVDSTPTNILNAVWIPTNLISNISNPRAIATISQKDSSPPNVPLSATVTGGAGTTIKWTCLQGATAGGLTTDNVANITVVPTTVGTFKYVISASDLPCSATDTVTITVNNTIPVSLVIDSPLCTSNTGKLKAVLPGGTTSADYKFNWAGAASPFIVAADTARDSLKNLPSGNYTLMIQLKSDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9I6S1</accession>
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        <recommendedName>
            <fullName evidence="6">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_19918</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Diplostraca</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.</text>
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    <comment type="similarity">
        <text evidence="5">Belongs to the histone H1/H5 family.</text>
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        </location>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Andrews J."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
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                <person name="Tang H."/>
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                <person name="Robertson H.M."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="275"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="275" mass="27981" checksum="F7C9DE0952BECE24" modified="2011-04-05" version="1" fragment="single">TSAPILNTFGISNVCPATTVDLTTLKASNQPAGAVLQWHTGLPISVNNKVSNPTSVNASGTYYAIFFDATNNCYANNGLSYAPIVVTITTCPSNCNAGGNAPVINVDAVSNICPATTVNLNNTTATNIPNGAVLQWHTGLPASASNKVSNPSSVLGGLYYAVFYDATNNCYSANGFGVKPIQVVITNCPNPCNAGTMAPVLSADSAINNCPQTTVDLTSITSSNTPNGTSLQWHTGLPASAGNKVANPAAVATGQGYIAKRVVASTSNCGPACYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9I821</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">DAPPUDRAFT_280700</name>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX59859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="313" mass="32938" checksum="7AB4B5F6134E23C6" modified="2011-04-05" version="1" fragment="single">MVTPRSRTVNIASGQAFGAGRFAAPPGPQLTIAASISAFLSSISASGASPPAPAPAPAAPSASNWAARSAIPGKTVWSHNFSNPGELTAFKQGNGTGVGDRAHVGPAIEPFIVDDPITGKAIRFIALGARLTSAFLASGGPGPRPIDIDDDYLWPDPALKGAYTVHLCDPDGGQDNNLVRITAKSGLTLTATWVNETGQPLTNGVQRDWPVGTHIGGQSAVNWSRHFSALKGDSNGRGVDDINLAGNVLRSMQDQTNFPHGTQAFGYGWYGRPEYQAEHATWRPSDSGAQAIDSILRSNLWDGDSFTLSWRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRA4</accession>
    <name>E9FRA4_DAPPU</name>
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        <recommendedName>
            <fullName evidence="9">CaMBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DAPPUDRAFT_94428</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90128"/>
    <dbReference type="EnsemblMetazoa" id="EFX90128">
        <property type="protein sequence ID" value="EFX90128"/>
        <property type="gene ID" value="DAPPUDRAFT_94428"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_94428"/>
    <dbReference type="eggNOG" id="KOG3684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="E9FRA4"/>
    <dbReference type="OMA" id="INSIWLV"/>
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    <dbReference type="PhylomeDB" id="E9FRA4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071805">
        <property type="term" value="P:potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004178">
        <property type="entry name" value="CaM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036122">
        <property type="entry name" value="CaM-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
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        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02888">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03530">
        <property type="entry name" value="SK_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01451">
        <property type="entry name" value="SKCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM01053">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81327">
        <property type="entry name" value="SSF81327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="CaMBD" evidence="9">
        <location>
            <begin position="303"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFX90128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="437" mass="49681" checksum="617D1ECE4CC7FDDB" modified="2011-04-05" version="1">MGKNRPNVGYRLGRRKALFEKRKRISDYALVIGMFGIIIMVIENELASAGVYTKASFYSTALKTLISVSTVILLGLIVAYHALEVQLFLIDNCADDWRIAMTWQRMSQISFELLICAVHPIPGEHYFLWTTKLANHGGVIGSKWVPVDVALSLPMFLRLYLICRVMLLHSKLFTDASSRSIGALNRINFNTRFVLKTLMTICPGTVLLVFMVSLWIIASWTLRQCERYHDEEHANLLNTMWLIAITFLSVGYGDIVPNTYCGRGIAVTTGIMGAGCTALLVAVVSRKLELTRAEKHVHNFMMDTQLTKRLKNSAANVLRETWLIYKHTKLVKRVNPGRVRTHQRKFLLAIYSLRKVKMDQRKLMDNANTITDMAKTQNTVYEIVSEMNTRQDVMEERLSTLEEKLTLLQETLEALPEAISRYLPAMPPPLPSKPKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRF8</accession>
    <name>E9FRF8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_299961</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90206"/>
    <dbReference type="EnsemblMetazoa" id="EFX90206">
        <property type="protein sequence ID" value="EFX90206"/>
        <property type="gene ID" value="DAPPUDRAFT_299961"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299961"/>
    <dbReference type="eggNOG" id="ENOG502SCV6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1697282_0_0_1"/>
    <dbReference type="InParanoid" id="E9FRF8"/>
    <dbReference type="OrthoDB" id="1646320at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000042">
        <property type="term" value="P:negative regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033045">
        <property type="term" value="P:regulation of sister chromatid segregation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036700">
        <property type="entry name" value="BOBF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032245">
        <property type="entry name" value="RMI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33962">
        <property type="entry name" value="PTHR33962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16100">
        <property type="entry name" value="RMI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101756">
        <property type="entry name" value="SSF101756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX90206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="155" mass="17428" checksum="971B4F6D8C9ECB2C" modified="2011-04-05" version="1">MQSDIVSDFFSAPTIKLFCRQLKDCKRLTSTDCLDDDENKAKLWLIPLESSTSGKQINYTVHNVWLQGTILSIINMSHFILKDVSGGIVKISLNSFPVTWIEQGAYCSVIGSITSSSQTPLIEAIKVTKLDNSHYLQILWAWEVKDLANELCDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRN3</accession>
    <name>E9FRN3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GLOBIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_231989</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX89883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89883">
        <property type="protein sequence ID" value="EFX89883"/>
        <property type="gene ID" value="DAPPUDRAFT_231989"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_231989"/>
    <dbReference type="eggNOG" id="ENOG502QS3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_13_6_1"/>
    <dbReference type="InParanoid" id="E9FRN3"/>
    <dbReference type="OMA" id="WTNEVED"/>
    <dbReference type="OrthoDB" id="1379813at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015671">
        <property type="term" value="P:oxygen transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLOBIN" evidence="7">
        <location>
            <begin position="9"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" description="distal binding residue" evidence="4">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX89883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="168" mass="18741" checksum="AC4160CA9A293B3A" modified="2011-04-05" version="1">MDFVEEAGANIVRERLEQILLLFETHPDMQSVFLPFTGVVLDDLKKSKLLSEHALRVMGAVQRAVHRLQEPEKLHAFLSELGRKHEKNGAKLEYIDYIGPQFLCAIRPILGDDWTLDTEKAWTLLLDYMTATMKESLVEARNASAAESSKPLTLPPSSSSSSSAATDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRT3</accession>
    <name>E9FRT3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Golgi apparatus membrane protein TVP23 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_299803</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TVP23 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX89902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89902"/>
    <dbReference type="EnsemblMetazoa" id="EFX89902">
        <property type="protein sequence ID" value="EFX89902"/>
        <property type="gene ID" value="DAPPUDRAFT_299803"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299803"/>
    <dbReference type="eggNOG" id="KOG3195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074845_3_0_1"/>
    <dbReference type="InParanoid" id="E9FRT3"/>
    <dbReference type="OMA" id="RSKMRHP"/>
    <dbReference type="OrthoDB" id="1356321at2759"/>
    <dbReference type="PhylomeDB" id="E9FRT3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030173">
        <property type="term" value="C:integral component of Golgi membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="PTHR13019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX89902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="216" mass="24431" checksum="52300B12CE1329CF" modified="2011-04-05" version="1">MASSASNAALIDDDTPGFGEEENPKQFRHPYVVLFHFGFRAAALIVYLFCGWFSDGFVTSFVFTVILLSLDFWTVKNITGRILVGLRWWSYVDGEGKSHWVYEARKEGDVRKVHAAESRVFWIGLIVFPLVWSILFILAIFRFSFRWLVLDCIALSLNGANVYGYLRCKLGKGTNLTGAVSNYANGFFRQQVMDKAVNMLTRQAQTSNVNSATNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9FS25</accession>
    <name>E9FS25_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KH homology domain-containing protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Brings lots of money 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_299833</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHDC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90391"/>
    <dbReference type="EnsemblMetazoa" id="EFX90391">
        <property type="protein sequence ID" value="EFX90391"/>
        <property type="gene ID" value="DAPPUDRAFT_299833"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299833"/>
    <dbReference type="eggNOG" id="KOG1960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_748556_0_0_1"/>
    <dbReference type="InParanoid" id="E9FS25"/>
    <dbReference type="OrthoDB" id="600891at2759"/>
    <dbReference type="PhylomeDB" id="E9FS25"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="PTHR15744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX90391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="370" mass="41033" checksum="E8C958DE3FFEA78B" modified="2011-04-05" version="1">MNNTVNSRNSLSSQSLQAAAQAAAQINAQLAAEGKIQPQQNLQASNNGAQKKDKKLKTGRKDLFNAEVEINNLPPRVRNLLTKGYIQEQIQWKSKAALCTKGRYVSQREKLTANDERPLYICIQAVDKHAVDEAIHHIQDFIAEHTGSSPTPPVISPTLVPNHPPPQVTLIRDKVYINLDHAPETFKIVERVLGPSGDNVNYIQTETGVSVSLQGQGISSSNASDEPHHLLLEHIEPSAVQNARSLALSLVGTLQQDFIQWQREQQALQQQQLVYTFSQPYYSGSSTASGNFTYPAVAMVYGMDNGLTQTAAVREPQSVQSHQHTRGLPGKRPSRFDYQQSTGVFPVRETARTSFHPHRMTADFLDIQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9FS46</accession>
    <name>E9FS46_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_94102</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX90379">
        <property type="protein sequence ID" value="EFX90379"/>
        <property type="gene ID" value="DAPPUDRAFT_94102"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_94102"/>
    <dbReference type="HOGENOM" id="CLU_1645416_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240267" evidence="2">
        <location>
            <begin position="32"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX90379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="161" mass="17489" checksum="A6673FDA0ECA539B" modified="2011-04-05" version="1">MEAEAGQVGRIGCLLVMILVLCAAGIETASGHRHHVSNSNHSHHQQGGTASKSRPLTKTDSSINQQDQGPMMTIKSLASSGTGERRVRKRSKWLQSTTSSAPSSSSSSMSHHFNKDSTFLKRIVTEVIAERDAQIAAALFEVAKNQPHLQMMVQTVRIVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E9FST8</accession>
    <name>E9FST8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like, SWIRM and MPN domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_232959</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. MYSM1 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX89763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89763"/>
    <dbReference type="MEROPS" id="M67.005"/>
    <dbReference type="EnsemblMetazoa" id="EFX89763">
        <property type="protein sequence ID" value="EFX89763"/>
        <property type="gene ID" value="DAPPUDRAFT_232959"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_232959"/>
    <dbReference type="eggNOG" id="KOG1279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018854_0_0_1"/>
    <dbReference type="InParanoid" id="E9FST8"/>
    <dbReference type="OrthoDB" id="590811at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035522">
        <property type="term" value="P:monoubiquitinated histone H2A deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033497">
        <property type="entry name" value="MYSM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF126">
        <property type="entry name" value="PTHR12802:SF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="7">
        <location>
            <begin position="353"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="558"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX89763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="820" mass="91490" checksum="55A647F6C07E5B5E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9FTX2</accession>
    <name>E9FTX2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_233375</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89566">
        <property type="protein sequence ID" value="EFX89566"/>
        <property type="gene ID" value="DAPPUDRAFT_233375"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_233375"/>
    <dbReference type="HOGENOM" id="CLU_1476596_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="183" mass="21281" checksum="50165F4DA0034A5B" modified="2011-04-05" version="1">MLLLAACTGRMSQPMQKHFTAEVTSEYDLQAVGWRCEQVSYCIQFVVLLLSVPNVLFRQIDFTFAVRVSWIFPLFTTILNIAILTTTSATKHQDDWMKNTHPQKLQPEKGKLHFLFARRSRRSLRKTCHATAERLGEDDTCFIIIKQFVIIIKYDVVLLLIVVLKYHTFKPPEYYTTTYVALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9FU73</accession>
    <name>E9FU73_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_95209</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89495"/>
    <dbReference type="EnsemblMetazoa" id="EFX89495">
        <property type="protein sequence ID" value="EFX89495"/>
        <property type="gene ID" value="DAPPUDRAFT_95209"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_95209"/>
    <dbReference type="eggNOG" id="KOG0550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_18_2_1"/>
    <dbReference type="InParanoid" id="E9FU73"/>
    <dbReference type="OMA" id="MIDHAEN"/>
    <dbReference type="OrthoDB" id="506649at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="1238995at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
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        <property type="entry name" value="TFP11/STIP/Ntr1"/>
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    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="PTHR23329"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G-patch"/>
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    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="103"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX87395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="367" mass="40554" checksum="A2D1287F48104AD3" modified="2011-04-05" version="1">MPSRFTPRHPFHQPFHGVSTKSPDAKRKEALERILQFNPVKAGDKDYTSPVGFVKGGVQQQTERGEIVETNENPGSSSESATNMSNDPRTSPSNEIGGWEKHTKGIGAKLLLKMGYKPGQGLGKSLQGRSEPIEAKVRKGRAAIGSEELLPPQSHHRSNAQQSLIEQKLKNKKFSKRKKNVLAAMPKAAEPPRRMNLIYPELSNYRSNKTLNILRSSMGDRITIDRTPDVICIASSDDEDCLILSDAENSSKTTLPSDDANRTTPARRTTPLKSPTSASSARSSAASCDVVCISSSDEEDCFILSDGETSPSNEIGARVSTALSDNKAPETFSWNRPKLSVSQRRIRKMRMKEWSQRRKIRHSISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1E6</accession>
    <name>E9G1E6_DAPPU</name>
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        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_312735</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX86484.1"/>
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        <property type="family name" value="Acidic_Lipase"/>
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        <property type="protein sequence ID" value="EFX86484"/>
        <property type="gene ID" value="DAPPUDRAFT_312735"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase"/>
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        <property type="entry name" value="Lipase_euk"/>
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        <property type="entry name" value="Abhydrolase_1"/>
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        <property type="entry name" value="Steryl_ester_lip"/>
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    </dbReference>
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        <property type="entry name" value="SSF53474"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240516" description="AB hydrolase-1 domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="138"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX86484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="461" mass="52525" checksum="9E28CE6E37DCE0B6" modified="2011-04-05" version="1">MVRLPSLIPFLIFMLCLYLASQLSQCSTVLNHERRSSSGRSIFRRKIRQSVSKVLSQMWQFSPRAHFSKKQLETDDKFINLTALPSNDERAMNAVQIIINRGYPVASYSVTTSDGYILELHRIPGRKGQTSDLGTGKPVWLQHGLLCSSADWLITPSDQSLAFILADLGYDVWLGNARGNVYSRKHKTLTHTQKSYWDFSWDEMGKFDIPAVLNFILFKTERKKLIYIGHSMGCSMFFVAMATYPELQSKIETMVALAPATSLAHMTSPIFRLAPFIKPLEFLLRLLKTRAFLSQESYLNYFQRKFCLKNIGWAGLCRNVLFLLVGDDTTNIDVEILRVLDGNTPAGTSVRTVAQFAMNFNSGPTFIPYDFGPVGNYLRYKKFRPPPYDLGKVKVPVYLFYGENDRLVTPKDIEWLASKLPNVKELVKVDDKHYNHASFLISKNNNVLLNNQLISFLPSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1F9</accession>
    <name>E9G1F9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_192770</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX86493">
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        <property type="gene ID" value="DAPPUDRAFT_192770"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_192770"/>
    <dbReference type="eggNOG" id="KOG2070">
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    </dbReference>
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    <dbReference type="InParanoid" id="E9G1F9"/>
    <dbReference type="OMA" id="LSRPFRH"/>
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    <dbReference type="PhylomeDB" id="E9G1F9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SH3DOMAIN"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48065"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50044"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="87"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX86493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="346" mass="39267" checksum="7484FBC9ED0EE2A5" modified="2011-04-05" version="1">MISEPPAITQVQAVYSFKGKNNDELNFKKGDIITITQKEEGGWWEGTFEGKTGWFPSNYVKDIGIIGAKPPQTIFAVETVPEQQTVNRNLILKDIIDSEKSYISEMQTLLKTVLTPLGNSDILTADEYSKIVRNLPEIVDLHATFNRLLEDCYEKSSLEQRVGSIFLSMAEKIKSVHTEYCSNHPRTVCILENYKEKLGSFVEGLGGRSPGLVFLTAGLSRPFRRLERYGGCLQELERHMEEFHPDRGDTQRSVFVYQNLASHCASVRRQKEQELEVLCGSVRCWEGDEPQRLGELVYMGPVKITTTTPITETKDRHLVLFSQCVILLSVSQRLSAFVFEVICLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1S9</accession>
    <name>E9G1S9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_97612</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX86762">
        <property type="protein sequence ID" value="EFX86762"/>
        <property type="gene ID" value="DAPPUDRAFT_97612"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_97612"/>
    <dbReference type="HOGENOM" id="CLU_840096_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX86762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="331" mass="34693" checksum="F5F0B00FD70C3DF5" modified="2011-04-05" version="1">MAEGADGSIWLRSINRQDGPSRYTPRLFACWLVLLVKCIRENGEFLGSYPISASQTTPSTPYGGPHHNAVQSGGYNNTAASWTTNNWNCGANNAAAAAAAAAAAAAAAAAASSSSSSGSPPISNNNNNNNNITNGAVGTLGASTSSAGSGGSSWASNHQLPWLSSAGEPFQHQQQHYSTNPAAAYGAGYMPSSHYGGAPTVHHSTDFGLPFSSAGYPVALPGSYPSGHYFFGSGENCGFYNNAGCQQQQQQPHQQQQYQQVSPVAVERSASTSSSPGFESHQQVQQQQQQQQQQVVLQQQVQVKEDLLSESFSDHSSPRQGWSPLTPPTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9G546</accession>
    <name>E9G546_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_300460</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX85442">
        <property type="protein sequence ID" value="EFX85442"/>
        <property type="gene ID" value="DAPPUDRAFT_300460"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300460"/>
    <dbReference type="HOGENOM" id="CLU_617145_0_0_1"/>
    <dbReference type="OrthoDB" id="1240248at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX85442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="444" mass="49960" checksum="FAA1672117A1E95C" modified="2011-04-05" version="1">MRICHVAKCGRKISDGVKLYHLPRNSVRRQLWLDKIKRREANRNTKIKNISICSKHFYGGKPAKEIYPRHPDYVPSLLLGDEPLELTDSPLLSVIQDHSLPIDDCKDIDWVPSPMIYDVVPEYFVECILNDSEDPLSLPDGSDLPNPTTSVPESSINFSSPIHTFLLTVDRPLTRHIVVQDKISIPNKPTPSVELNLNCSLSNLVTPTVQNYRMEVSSSASCKLLDHSYVLVPPKSPTSPGEGAAASSTSRNSQSATSQEPQENAAPYESDHNYVLRSSSTPTVNESEESLHLDMAGYRNFIDGVATPTADWTWSFNERNNNLVCSCHFFSHDGVMTIKSVKIITRNKVALYLNAKLITPQDIQLEFRSKAELAKILEDFHHRKICQGIVDDSLADVEVTDKCARNKEDNLWCSKMRMEIAGSNLCSNLSIMPPFYRLLEENYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E9G581</accession>
    <name>E9G581_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_46226</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85429"/>
    <dbReference type="EnsemblMetazoa" id="EFX85429">
        <property type="protein sequence ID" value="EFX85429"/>
        <property type="gene ID" value="DAPPUDRAFT_46226"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_46226"/>
    <dbReference type="eggNOG" id="KOG1943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2177300_0_0_1"/>
    <dbReference type="OrthoDB" id="79003at2759"/>
    <dbReference type="PhylomeDB" id="E9G581"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034333">
        <property type="term" value="P:adherens junction assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="PTHR12658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX85429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="110" mass="12806" checksum="64BE1665931F56F3" modified="2011-04-05" version="1" fragment="single">FLSSLFVAQYEEYRPHLIQHLVDRKVIHWDTLLIRIFVQALHQMTFLDPESMKLILSTQILPRCTNPELYLRHGSILASGKVISALCQVTKDHQRRLPDELGQLPLVISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7B0</accession>
    <name>E9G7B0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_238758</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84679">
        <property type="protein sequence ID" value="EFX84679"/>
        <property type="gene ID" value="DAPPUDRAFT_238758"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238758"/>
    <dbReference type="HOGENOM" id="CLU_2724755_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="72" mass="7716" checksum="FCC6E04A6073F311" modified="2011-04-05" version="1">MSIIVPDNPANDSNGYFPVSDGDGLGDSTSIVPDKFQSIFDPWGDYVFATVMIVIVTLVIDDDNIVNSCSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7B9</accession>
    <name>E9G7B9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein kinase PLK</fullName>
            <ecNumber evidence="9">2.7.11.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Polo-like kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DAPPUDRAFT_301125</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="9"/>
    <dbReference type="EMBL" id="GL732534">
        <property type="protein sequence ID" value="EFX84439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84439"/>
    <dbReference type="EnsemblMetazoa" id="EFX84439">
        <property type="protein sequence ID" value="EFX84439"/>
        <property type="gene ID" value="DAPPUDRAFT_301125"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301125"/>
    <dbReference type="eggNOG" id="KOG0575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_46_1_1"/>
    <dbReference type="InParanoid" id="E9G7B9"/>
    <dbReference type="OMA" id="HPPFESK"/>
    <dbReference type="OrthoDB" id="507604at2759"/>
    <dbReference type="PhylomeDB" id="E9G7B9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="12">
        <location>
            <begin position="403"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="12">
        <location>
            <begin position="501"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX84439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="586" mass="66808" checksum="34FA9D550A369BDA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9G7R8</accession>
    <name>E9G7R8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_238907</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX84527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX84527">
        <property type="protein sequence ID" value="EFX84527"/>
        <property type="gene ID" value="DAPPUDRAFT_238907"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_238907"/>
    <dbReference type="HOGENOM" id="CLU_3144315_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX84527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="49" mass="4865" checksum="A13F9837D81CFAA1" modified="2011-04-05" version="1">MEPHGTRAQCEESGGVVKACHGGTASRDSACDQGGDGVDEPPAASHCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8W2</accession>
    <name>E9G8W2_DAPPU</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84043"/>
    <dbReference type="EnsemblMetazoa" id="EFX84043">
        <property type="protein sequence ID" value="EFX84043"/>
        <property type="gene ID" value="DAPPUDRAFT_194691"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_194691"/>
    <dbReference type="eggNOG" id="KOG0776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_827065_0_0_1"/>
    <dbReference type="InParanoid" id="E9G8W2"/>
    <dbReference type="OMA" id="DKNQQAW"/>
    <dbReference type="OrthoDB" id="858404at2759"/>
    <dbReference type="PhylomeDB" id="E9G8W2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX84043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="336" mass="37110" checksum="36C13A74B97CB559" modified="2011-04-05" version="1">MVSRNGLICWKTLQSGCIRSTNPVNVTISRRLCVSSQICQNNWVQAVSNAEKIVGLPTSFLSLRSEAIDEISNIAVYLKKLIGTGHPLLDTAKNLMYSQDKTNQTRGLLVLLVSKAAKIDQTQDILPKQRTLAEITDLVHAAHLIHTGVINLNTPNESLEMGNKMAVLCGDFLLARSCVLLANLQNLKVVELIAQAISDFSTAEFIDIVANETDSALDRWRYQSKLRYGTLLAHACQSSLILGDNVDLVEFGKYFGLEIALAWQANNEIQSYKNAKEKADHVLFKLFPPGTPFKEVISNFQAVRDTHVDAALQMLGELPKNDASLALCNIARALKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAC4</accession>
    <name>E9GAC4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_301670</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83735">
        <property type="protein sequence ID" value="EFX83735"/>
        <property type="gene ID" value="DAPPUDRAFT_301670"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301670"/>
    <dbReference type="HOGENOM" id="CLU_837467_0_0_1"/>
    <dbReference type="OrthoDB" id="1704971at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="332" mass="37630" checksum="9BE0A7ADABB924FA" modified="2011-04-05" version="1">MPWPTSPSNAVEVVFCRTKCDKMAVIHQNYYFHHNRKYKGGDYWCCAHRGCKVRLISSRVNHESGRMEFSRRNQAIQHEHEPNAPNLIEKEFRRQLVTQFDRVTANKSGSPQSATPVSVRLVYDELRSQAIKRGVPESLIPSYWNIRSTMYRIRRKRVLLHVPSSNSGSERRETNETSAGEGSARSGTSDPESPISSTMGEPSTSPVQSEPLSLVTWKNNAQEQQLVVRRDLVHPTTSPILYQSLQTSGSPSTAPINPQLPTQFEASPMITPIPPIDPNLLRFSSHFFPSYSQSPNIAPSFPYQSPEIMRFYAAMHAEYLRSLFALGCHPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAL8</accession>
    <name>E9GAL8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_239996</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83271"/>
    <dbReference type="EnsemblMetazoa" id="EFX83271">
        <property type="protein sequence ID" value="EFX83271"/>
        <property type="gene ID" value="DAPPUDRAFT_239996"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_239996"/>
    <dbReference type="eggNOG" id="KOG0517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_639773_0_0_1"/>
    <dbReference type="InParanoid" id="E9GAL8"/>
    <dbReference type="OrthoDB" id="543832at2759"/>
    <dbReference type="PhylomeDB" id="E9GAL8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX83271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="429" mass="49496" checksum="3DEECA258F00968D" modified="2011-04-05" version="1">MDLVMEEGEEELTKHKALELELDTYGLINEMGNMAMVSNNHLDSKVITQRQHLLSQGMKNPQKLASHRRQRLVDSGHDEWSKLLETVELRDEKLVAAGEIHRFNRDVAESLSRIQEKYVAIPDDLGRDLDSVLGLIRRHENFETDLVALEAQLQVCIHHNIQSWWMIRPNYKWHTAYPGGNAGHIRAQQALVIESWTTLQERMARRKEELQDSFVFQRFLTTVRDLVTWSSGLVANMSSTEKVHDANEAQALRAEHDRLKGEIEAREDVFSSAVQAGETMIQEEHYSAAEIKDRLIQLLQEREKLHAIWQQCRGRSIWTSYWIFNFSEAALLGTDLGSTAEEVMAQFKKHEAFDKLVQAQDERLALLMEHGEKLIGQNHFESQWIMKRVAEVTAKRLQKHQAFQAEVGAHQGRLNEIKPNQTNGRNTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAW1</accession>
    <name>E9GAW1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_240103</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83475"/>
    <dbReference type="EnsemblMetazoa" id="EFX83475">
        <property type="protein sequence ID" value="EFX83475"/>
        <property type="gene ID" value="DAPPUDRAFT_240103"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_240103"/>
    <dbReference type="eggNOG" id="KOG0042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_2_0_1"/>
    <dbReference type="InParanoid" id="E9GAW1"/>
    <dbReference type="OMA" id="AHEYEPL"/>
    <dbReference type="OrthoDB" id="669193at2759"/>
    <dbReference type="PhylomeDB" id="E9GAW1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX83475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="427" mass="47605" checksum="AF2043B0135C59E3" modified="2011-04-05" version="1">MNLNEPGLTIAGTTDTPCEVTHHPSPTEADIEFILGEIRSYLSPDIEVRRGDVLSAWSGIRPLVSDPNKPDSQSLVRNHIVHVSDSGLVTIAGGKWTTYRSMAMETLDAAVKTCNLPAVRGSATDGLLLEGAHGWTPTMFIRLVQDFGLESEVAKHLSETYGDRAFSVAKLAALTGKRWPIVGKRLHEEFPYIDAEVRYAVREYACTAVDVIARRLRLAFLNVQAAEEALPSIISIMAEELKWSEDEQKRQHAEAVKFVREEMGQQVNRQSRDKIPINLSREEISNYIKRFQALDHDKKGYISINDIRRGLKVGDLIPNHEISGEEIHAALNKVDLRLNGQTDLSEFIQRQGESISGTMMHEILREVDVNANGLVELDEFLQLMACIKSGRVTNSRFDQLAQEAQKDAEEEEAKRKAIPVDRSGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9GB55</accession>
    <name>E9GB55_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_100705</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83374"/>
    <dbReference type="EnsemblMetazoa" id="EFX83374">
        <property type="protein sequence ID" value="EFX83374"/>
        <property type="gene ID" value="DAPPUDRAFT_100705"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_100705"/>
    <dbReference type="eggNOG" id="KOG4141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054400_0_0_1"/>
    <dbReference type="InParanoid" id="E9GB55"/>
    <dbReference type="OrthoDB" id="1572665at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="PTHR12132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX83374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="408" mass="45249" checksum="C87E261327DEC495" modified="2011-04-05" version="1">MQRPVKFGRIEYDVEEHKVLQSTLRKDLAPEMVSQRHGPGGQKLAYIEGWRLIALANEVFGFNGWSHQVVQQTIVCGLDCVDQVDDKFYVGVSSTVRVELKDGSFHEDIGYGVCEGMKSKALSLEKARKEAATDGLKRALKGFGNVLGNCLNNKNYLRWANKYPVTTPAPPQKNETVLEVPPAVHRSRYNAMEEKKRGIEALKTPSAASTSVPIIEKNVDATHESTHPMPAPQEPAPQCPGLPTGQKLISTKETALTSIKPPNISGAQNGETINNSALKDDLLNESDPVKLERKRKQQQKKEEFLQQLKRQKQEDGARISTVSIKSEQTSPVPEDDSEKWMREVDPESFALISGIDWSDEENPAPYQAIINKPNVNTVTKPAPHKPAPHKPAPHKPALAVPKANNFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBV3</accession>
    <name>E9GBV3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_302148</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732538">
        <property type="protein sequence ID" value="EFX83092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83092">
        <property type="protein sequence ID" value="EFX83092"/>
        <property type="gene ID" value="DAPPUDRAFT_302148"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_302148"/>
    <dbReference type="HOGENOM" id="CLU_1050743_0_0_1"/>
    <dbReference type="OrthoDB" id="1153592at2759"/>
    <dbReference type="PhylomeDB" id="E9GBV3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036272">
        <property type="entry name" value="Methuselah_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63877">
        <property type="entry name" value="SSF63877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX83092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="224" mass="25124" checksum="D449315EEA2205A4" modified="2011-04-05" version="1">MDNYTPVIRCCKSGTTYLTGLDKCVPNYVSTLYNESFPNYSFEDATDGLTDCPDGYVSHSTEDFKLDNDTLLVGEKRLESNEFCINRIEEENYSTSPGKFVARYCVPDPCGESGCIRKCCPPGMAMVMKYYHDLSPISICEPHPVPFNLSLLRNPKNESIDANSFSTRGGLGIKCGKLPRDQLLNFSMRPDGQIILHLESLPDEKTDQYCIENNVVDGEDIVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBX5</accession>
    <name>E9GBX5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_240595</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="GL732538">
        <property type="protein sequence ID" value="EFX83079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83079"/>
    <dbReference type="EnsemblMetazoa" id="EFX83079">
        <property type="protein sequence ID" value="EFX83079"/>
        <property type="gene ID" value="DAPPUDRAFT_240595"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_240595"/>
    <dbReference type="eggNOG" id="KOG0741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008037_2_1_1"/>
    <dbReference type="InParanoid" id="E9GBX5"/>
    <dbReference type="OMA" id="CQRIREV"/>
    <dbReference type="OrthoDB" id="197562at2759"/>
    <dbReference type="PhylomeDB" id="E9GBX5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="PTHR23078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="31"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="308"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX83079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="486" mass="53819" checksum="87D3A15A213DF359" modified="2011-04-05" version="1">MGVGGLDTEFSAIFRRAFASRVFPPEIVEHIGNMSLFMNRKTLMARQIGKMLNTREPKIVNGPEILNKYVGESEANVRRLFAEAEEDEKRLGPNSGLHIIIFDEIDAICKSRGSVAGASGVNDTVLTQLLAKIDGVGQLNNILVIGMTNRRDLIDEALLRPGRMEVQMEIGLPSETGRVQILLIHTARMRENKKMAADVDLQELAVLTKNFSGAEIEGLVRAAQSTALSRFIKASNKVEIDPEAGEKLMIDRGHFLHALENDIKPAFGTSSEALELYIERGIIHWGEPVRSLLEKGVILTQKARSGFGLVSVLLEGPPNAGKTALAAQLAKNSDFPFIKICSPDDMIGFSESAKVLRIRRFFDDAYRSELSCILVDDIERLLDYGAIGPRYSNLVLQALLGLLKKKPPKGRKLLVICTTSRRQVLKELEMLSIFTKILRVPNISTSEQLIAFVTLRHYFFIGVSTSILNVCIRAVRHHASSCILMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9GBX6</accession>
    <name>E9GBX6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="2">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_240596</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="2"/>
    <dbReference type="EMBL" id="GL732538">
        <property type="protein sequence ID" value="EFX83078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83078"/>
    <dbReference type="EnsemblMetazoa" id="EFX83078">
        <property type="protein sequence ID" value="EFX83078"/>
        <property type="gene ID" value="DAPPUDRAFT_240596"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_240596"/>
    <dbReference type="eggNOG" id="KOG0741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172763_0_0_1"/>
    <dbReference type="InParanoid" id="E9GBX6"/>
    <dbReference type="PhylomeDB" id="E9GBX6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="PTHR23078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDC48_N" evidence="3">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX83078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="111" mass="12645" checksum="06CDCBA400776B40" modified="2011-04-05" version="1">MSNLMLDSGMKAAKCPKEELSLTDCAFVNPEDFNDSVKHIEVSTSPEQCFVFSVKSHKDVLQSTIGFNKLQRKWATLSIGQDIDVRPFKFDINKHTLATIILEVDFHDKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9GDH5</accession>
    <name>E9GDH5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_241133</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732540">
        <property type="protein sequence ID" value="EFX82476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX82476">
        <property type="protein sequence ID" value="EFX82476"/>
        <property type="gene ID" value="DAPPUDRAFT_241133"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_241133"/>
    <dbReference type="HOGENOM" id="CLU_2560590_0_0_1"/>
    <dbReference type="OrthoDB" id="460569at2759"/>
    <dbReference type="PhylomeDB" id="E9GDH5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX82476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="82" mass="9014" checksum="FDF12EE0495749E3" modified="2011-04-05" version="1">MLLSQGGPCTSKRLPFRLVAGVWTLAAFIFVQAYNSTLFTYVMAPVNHPLIDSMHGVAESADINLLFRYGAALNAFVMLFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9GEQ6</accession>
    <name>E9GEQ6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_317034</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Shapiro H."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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    </evidence>
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    </protein>
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        <name type="scientific">Daphnia pulex</name>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the galactose-3-O-sulfotransferase family.</text>
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    <dbReference type="PhylomeDB" id="E9GI05"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="P:glycolipid biosynthetic process"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX80928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="374" mass="43748" checksum="732E4BD88CC3AAE0" modified="2011-04-05" version="1">MSFPYTIPSKVDKSLNESSTTSFKTCRKFAFMKNHKCGSSTIENIIFRFANKNHLNVVLPDSGNYLSTIDLFNHKSLANTKWKDLPFDIFSLHNRWNRNEVMKVLDDEVPTFTIVRDPVEVFVSMFHYQDKFREFYGVKDIHDMVVKIQENPSAPELNQRWMKYVGRNQMSWDMGLSPDIFDNEVAMLSEIERLDREFDLVMVSNRMDESLVLLMHLLPWSFKDVIHLDLNRRKPDKSSALSDEELDVLSNWLAADTQLFKYFNRRFDERVTELNQKYSSVMDLIWRSGADEEANYVKHQTKMLKEANRELYDLCVVQEVGNEKLSGVFKETNDNVMGYVINTEEEGCALFAMSEPAFLKIFRKQLLSQALDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9GIZ2</accession>
    <name>E9GIZ2_DAPPU</name>
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        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_304081</name>
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    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732547">
        <property type="protein sequence ID" value="EFX80571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80571"/>
    <dbReference type="EnsemblMetazoa" id="EFX80571">
        <property type="protein sequence ID" value="EFX80571"/>
        <property type="gene ID" value="DAPPUDRAFT_304081"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304081"/>
    <dbReference type="eggNOG" id="KOG0107">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_20_5_1"/>
    <dbReference type="InParanoid" id="E9GIZ2"/>
    <dbReference type="OMA" id="YVEFEDH"/>
    <dbReference type="OrthoDB" id="1533297at2759"/>
    <dbReference type="PhylomeDB" id="E9GIZ2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX80571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="162" mass="18115" checksum="90A731B437D62BA5" modified="2011-04-05" version="1">MSSRHQDWDPRCKVYVGNLGSNAARGEIEEAFSKYGTLRNVWVARNPPGFAFVEFEDPRDAEDAVRALDGVRLCGARVKVEMSTGKRRSNGFGGDRGGRGGDRRGGGGPPARRGGGYSPRRSRSRSRDRFRDRKASRSVSRDRVRRDSRSRSRSPSYSKYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJQ5</accession>
    <name>E9GJQ5_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_51546</name>
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    <organism evidence="2">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732548">
        <property type="protein sequence ID" value="EFX80276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX80276"/>
        <property type="gene ID" value="DAPPUDRAFT_51546"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_51546"/>
    <dbReference type="HOGENOM" id="CLU_004416_3_1_1"/>
    <dbReference type="InParanoid" id="E9GJQ5"/>
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    <dbReference type="PhylomeDB" id="E9GJQ5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX80276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="84" mass="9631" checksum="F7474115FE5FC0C9" modified="2011-04-05" version="1">MINKESRVMKIQINIDGTQIFKTNSLDLWPILVRVTNSLDALPFVVSLFIGKGKPTNLEDYLKPFLEELIALQTEGLQFEDICY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJV1</accession>
    <name>E9GJV1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732548">
        <property type="protein sequence ID" value="EFX80177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80177">
        <property type="protein sequence ID" value="EFX80177"/>
        <property type="gene ID" value="DAPPUDRAFT_304205"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_304205"/>
    <dbReference type="eggNOG" id="ENOG502SAEC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099694_1_0_1"/>
    <dbReference type="InParanoid" id="E9GJV1"/>
    <dbReference type="OMA" id="VHENACK"/>
    <dbReference type="OrthoDB" id="1463362at2759"/>
    <dbReference type="PhylomeDB" id="E9GJV1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="170" mass="19437" checksum="A63BF8149967D1F2" modified="2011-04-05" version="1">MSCIDEFKDQCLNQRQKIQMERAVAGAQHTFAFLCDDPVFQSEFLQHQSCLHGTSDDWERCAYHFQNMVAEELAANLTKADRNLGLCCAKHGFLRCVYYAAQFKCRKEEALFLMRVAQTLTESQVHENACKKIKFDEVCASDSGVPTVSSLLLTLVAIWWSSISFLLMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKG2</accession>
    <name>E9GKG2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_244214</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732549">
        <property type="protein sequence ID" value="EFX79988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79988">
        <property type="protein sequence ID" value="EFX79988"/>
        <property type="gene ID" value="DAPPUDRAFT_244214"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_244214"/>
    <dbReference type="HOGENOM" id="CLU_1798402_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="SSF90209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX79988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="144" mass="16344" checksum="92BCF140A56AC624" modified="2011-04-05" version="1">MNTFQVAMLIAFQHTDAVTCEELLKATRLKPMADDAPGCLDANDDAPELDAKKEWDCSKCGAKNDGNFKFCHRCLRCETDEDSSESVCPDSFLQLDDEVEEEEEEEEEEEEAVAGPKKPKHIVKKEAKLKAYKKRKMNLIRTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKU2</accession>
    <name>E9GKU2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_51873</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732550">
        <property type="protein sequence ID" value="EFX79739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79739"/>
    <dbReference type="EnsemblMetazoa" id="EFX79739">
        <property type="protein sequence ID" value="EFX79739"/>
        <property type="gene ID" value="DAPPUDRAFT_51873"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_51873"/>
    <dbReference type="eggNOG" id="KOG1023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016632_1_0_1"/>
    <dbReference type="InParanoid" id="E9GKU2"/>
    <dbReference type="OMA" id="YKMFDSK"/>
    <dbReference type="OrthoDB" id="531253at2759"/>
    <dbReference type="PhylomeDB" id="E9GKU2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006182">
        <property type="term" value="P:cGMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="4">
        <location>
            <begin position="242"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX79739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="403" mass="45563" checksum="990CA5D1B0FA7080" modified="2011-04-05" version="1" fragment="single">YNVANDLILDQLSTRIRQTSTTGAWRLLIAFKFVIRSIENFSIAIVYGLYYFGKGHLSLDNYARYVRYDSLAQDYLNATQQFSSSSQNIYELFVDNFPYYDNLTARLEVYANLERTPDNEIATTYYDYMSLYIDSLRMHQDKLRDEILLSVEQELEGAGTLQTVTICILTLVLFISPFIIFLVRNATQTIQTFASGLVSKTTELKRERKRCDRLLCQMLPKAVVRQLKQRRQVPAESFDSVTIYFSDIVGFTAISASSTPLEIIAFLNALYKMFDSKLERYDVYKVETIGDAYMVVSGLPHRNGLKHVGEIATMSLDLIAGVKNFKIPHRPNQSVSIRIGFNTGPCVAGVVGTKMPRYCLFGDTINTASRMESTGEAMKIHISASAKEALDAVGGYYTELRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9GLS5</accession>
    <name>E9GLS5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_304439</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX79557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EFX79557"/>
        <property type="gene ID" value="DAPPUDRAFT_304439"/>
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    <dbReference type="eggNOG" id="KOG0139">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="E9GLS5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
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        <property type="term" value="F:butyryl-CoA dehydrogenase activity"/>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA_DH_CS"/>
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        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
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        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
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    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
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        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
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        <property type="entry name" value="AcylCoA_DH/ox_N"/>
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        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
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        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX79557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="406" mass="43469" checksum="CEBD3DAB6AA712C1" modified="2011-04-05" version="1">MALQLRRLSLGLAKFQQARNASILTSLPETHELLRKTCRDFAEAELKPNAARFDKEHLYPKEQILKMGELGLMGIVVPEDFGGAGLDYLAYAVAIEEISRGCASAGVIMSAHNSLYLGPLLKYGNDQQKRDWVQPFAGGDKIGCFSLSEPGNGSDAGAASTTAVTSADGGWTLNGTKAWITNGYESEATVVFATTDKSLKHKGISAFVVPKPTPGLSLGKKEDKLGIRGSSTCNLIFEDCHIAKDNLLGKPGLGFKIAMSILDGGRIGIAAQALGIGQAALDCAVDYASKRKAFGQPITKLQSIQNKIADMALQLESARLLTWRAAALQDEGRAFIKEAAMAKLAASEAATFISHQAIQILGGMGYVSDMPAERHYRDARITEIYEGTSEIQRLVIAGNVLKEYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9GMG8</accession>
    <name>E9GMG8_DAPPU</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_304880</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="match status" value="12"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX79363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1435" mass="159675" checksum="FEE6EDE66DC64C34" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
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    <accession>E9GMW3</accession>
    <name>E9GMW3_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_104646</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732553">
        <property type="protein sequence ID" value="EFX79162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79162">
        <property type="protein sequence ID" value="EFX79162"/>
        <property type="gene ID" value="DAPPUDRAFT_104646"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_104646"/>
    <dbReference type="HOGENOM" id="CLU_788137_0_0_1"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="PhylomeDB" id="E9GMW3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX79162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="352" mass="39757" checksum="DD9CCE6B45D1F873" modified="2011-04-05" version="1">MSTKPESLENKIEHLEYHIQDLKARKKAYQETEDQYEKNFQDIANKTFETTKFLDELQNFTTGDSIDRSIHTELDNEKTNTIINLQEIVDNLTAQNNSQATTICQLQKRNTVLKKNRRVSISVTVLDTGASHSGDDDVSTSQGPLTSRFSKTLINAPDATILESGTKPIVKVLGELFSREDKKSIPTFKAVQRTPKFVLTGQEQKILFVHKKIVIPVTTEAETTVTLVAENKVHQAIGVAIHVATDVHTRKETSRDTKITALENPINLITITTDLQIDPRQDYGDQRKNYNNAPRAWPTVQNNSAYIEGTGPGNNQWLGQRDIVWYNCNKRGHIARVGQTMEARINNLFLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQK3</accession>
    <name>E9GQK3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_105376</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX78311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78311"/>
    <dbReference type="EnsemblMetazoa" id="EFX78311">
        <property type="protein sequence ID" value="EFX78311"/>
        <property type="gene ID" value="DAPPUDRAFT_105376"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_105376"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_9_0_1"/>
    <dbReference type="InParanoid" id="E9GQK3"/>
    <dbReference type="OrthoDB" id="1314811at2759"/>
    <dbReference type="PhylomeDB" id="E9GQK3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="80"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX78311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="322" mass="34181" checksum="5AC4CF833D1D5ADA" modified="2011-04-05" version="1">MVQLPGFNPYAMMQQKPQKVFYNGWPFFFGYPTPTGPSTRQFYGEEAQFRQQTGVAPAPTPAPTPAPTPAPTPAPTPAPATCGRGPVKFPGTRSLISGRITTGTDVILKNSAGTLFCSGALISDTKIITAAQCFEKMSAFEMQGVTVLIGMTSQTDVQMSRRVQRLVLHNRFNAFTYANDIAIVTMDSPVVISNTVQPVCLAATNPNPDQYADQDAIILGWGTAKIGTPSAALMQGKVGIVANSECRADPDFGKYVLDSNICVTSKTAFSCAGDVGGPVVILSAPGTWTLVGINSYTKADCSATGLKTAISAFKTWIDLFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9GR43</accession>
    <name>E9GR43_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphnia</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
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                <person name="Sakarya O."/>
                <person name="Salamov A."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732559">
        <property type="protein sequence ID" value="EFX77945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_320798"/>
    <dbReference type="HOGENOM" id="CLU_1847149_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="82"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX77945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="139" mass="15377" checksum="7B8AEDF1BF00E797" modified="2011-04-05" version="1">MAPCSTSGDHLLLETYSTKVSGLPMSYEDYLKNRKSERSIEVKDEDSVAVTRQEHIIFPKSIKPPTPGNETPAVPNSLDNATAQNTNPTNILVFNPQSTDLFASVDADDVIRVWDIKNGSVTIKLEPHPDQMTTNTTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GSB4</accession>
    <name>E9GSB4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_321225</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732561">
        <property type="protein sequence ID" value="EFX77698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77698">
        <property type="protein sequence ID" value="EFX77698"/>
        <property type="gene ID" value="DAPPUDRAFT_321225"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_321225"/>
    <dbReference type="HOGENOM" id="CLU_1628731_0_0_1"/>
    <dbReference type="OrthoDB" id="1835310at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="163" mass="18063" checksum="DA401896E55DBEC0" modified="2011-04-05" version="1">MQSRRLSVSAISAVLVIWTLLALTLTAQWVILLSSNRVAIVKRGKMLICGCQGLAVLSLLASIALLSVQYEVNKWKEDNIKILVGVIVGTNCLNILTLCLIFVFIVRGQKNVHQVIGSWLWLAIQQHIQRQQLLLEEGGDISLKEHLQAAYDAEELNFSSEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTU6</accession>
    <name>E9GTU6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_106456</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732564">
        <property type="protein sequence ID" value="EFX77145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77145"/>
    <dbReference type="EnsemblMetazoa" id="EFX77145">
        <property type="protein sequence ID" value="EFX77145"/>
        <property type="gene ID" value="DAPPUDRAFT_106456"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_106456"/>
    <dbReference type="eggNOG" id="KOG0203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1397656_0_0_1"/>
    <dbReference type="InParanoid" id="E9GTU6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:cellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:cellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX77145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="195" mass="21894" checksum="A586E136B2543AF7" modified="2011-04-05" version="1">MDKKGLTSAQAKANLERDGIIASPLTSPPQTTPEWINFCKQLFGDFSMLLWVGAILCNVAYDIEYSQNPDILGDNESKSSKIMESFKNLVPQSAFVIRDGQKQTVKAEEVCRGDTVEVKFGDRIPADIRVIEARQFKVYNSSLTVESEPQSRSPEFTNDNPLETKNLAFFSTDVVEGTKNYCLTLSPRMSGFWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GUM7</accession>
    <name>E9GUM7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_106658</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX76910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76910">
        <property type="protein sequence ID" value="EFX76910"/>
        <property type="gene ID" value="DAPPUDRAFT_106658"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_106658"/>
    <dbReference type="HOGENOM" id="CLU_1742421_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="150" mass="17264" checksum="E5A252F49E7955F3" modified="2011-04-05" version="1">MATNDIKQVQNAQVMERLGLRVVLITIPRSNSEETQQSKRVQSKRKLESITHQNTIKQIEEQRELEGRKPIEDQNEKKSDSSYVSASMPDLESSTNEDEGDFEHENVFPPDRSNTIDVVKDTVLQSKTIHCQCCEDKIHLLEMPQDELNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9GUN1</accession>
    <name>E9GUN1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_Tnp_Tc3_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_106660</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Detter J.C."/>
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                <person name="Frohlich T."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
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                <person name="Choi J.H."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Koonin E.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Tsuchiya D."/>
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                <person name="Zdobnov E.M."/>
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        </citation>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <reaction evidence="1">
            <text>2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate</text>
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            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
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        <property type="gene ID" value="DAPPUDRAFT_306710"/>
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    <dbReference type="eggNOG" id="KOG3889">
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GBBH-like_N_sf"/>
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        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02410">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBBH-like_N" evidence="17">
        <location>
            <begin position="67"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="TauD" evidence="16">
        <location>
            <begin position="174"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
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            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX75501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="418" mass="48484" checksum="3D17C87A28B5293E" modified="2011-04-05" version="1">MSILKFKSILPKLSSGILRNTLLPTKIVPLKILCKYSSGSNLQTQENEHYDRPKLLNVHLPNTSEPLKLHPIWLRDHCRCPECYNDVTCQRNNDILKLSDQIAISTYSQSDDLLHICWSDGHKSSYSIPWLVSNTYDGKYKALQEETDRLTTWDGTTVNLLGLEPISHQRLMSDDKILREIYRRVIQYGFVKIEQVPPTKLDTSAVIERICRMSHTVFGKFWETGTNFDHKDTGYLNGYLEAHTDNTYFTEAQGLLVFHCTHFDGTGCESFLVDGFHVAKQLKQLDPSAYGYLSKVNMESEYIEPGEHFSSWGPIFRHHPVSHKLEQIRFNMLDRSPLSSIPQEEVGTHYRYLKTMATLVKKKENEYRFRLSPGTVMIIDNWRLLHGRESYQGERVLRGCYYSRSDFMSKARHYGIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYF3</accession>
    <name>E9GYF3_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_107848</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="192" mass="22065" checksum="F2230CF4293C242D" modified="2011-04-05" version="1">MRPSPIRKRLIKLYSDRLDWTPAVLDNFVTFISRMVTSPCSSILDLVFQNEFTPIHALYWLYHSFYTEGARRQEIFVIDTVLCARQRIFNMFGDFAIILLLPELDWSVRRQLTHSLQLDQTAGRAAGRVALRFPASLVKCLRKRLARTITLERSSPSSPSWPIMATFGSPYSSPSLFIKVKKSSRVSFNNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYJ5</accession>
    <name>E9GYJ5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2">
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732575">
        <property type="protein sequence ID" value="EFX75405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75405">
        <property type="protein sequence ID" value="EFX75405"/>
        <property type="gene ID" value="DAPPUDRAFT_306757"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306757"/>
    <dbReference type="HOGENOM" id="CLU_2457062_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="89" mass="10444" checksum="9323B7910A163690" modified="2011-04-05" version="1">MAVRRAKSFYRSNKRLDLIQPPVSNRPPEVWARFRLNDSAPQMTTWNLNEKMASILLPVQTRCLQKLSLSRFRPSILNSQTEQIHKCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9GYM9</accession>
    <name>E9GYM9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="9">
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        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="GL732575">
        <property type="protein sequence ID" value="EFX75425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75425"/>
    <dbReference type="EnsemblMetazoa" id="EFX75425">
        <property type="protein sequence ID" value="EFX75425"/>
        <property type="gene ID" value="DAPPUDRAFT_306770"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306770"/>
    <dbReference type="eggNOG" id="KOG2899">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082749_0_0_1"/>
    <dbReference type="InParanoid" id="E9GYM9"/>
    <dbReference type="OMA" id="GNFMNYY"/>
    <dbReference type="OrthoDB" id="1185441at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010586">
        <property type="term" value="P:miRNA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000632">
        <property type="term" value="P:negative regulation of pre-miRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="PTHR12315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="7">
        <location>
            <begin position="31"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX75425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="254" mass="29471" checksum="1667C971E2B9A245" modified="2011-04-05" version="1">MAKNKKNDDEFEPGAAQFGNFINYYEFNPPKNRLALFEGKFCECFSSDKRKILCLDVGCNTGELTRGLHEMLSSGQAAVRMMGVDLDPQLVQRANETIANEPESEMQFHALNVVTQVEERDQLWNRYLESQEPERKRFDIAFCFSTTMWIHLNHGDAGLESLLACLATWADNVVIEPQPWKCYRNAARRLRRANRPPFPLFDSLVHRSSVHDHIDDIFRNRLGMELHTHLGHSEWQRPVLWYRHKPTANLAISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZM1</accession>
    <name>E9GZM1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_323736</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732578">
        <property type="protein sequence ID" value="EFX75082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75082">
        <property type="protein sequence ID" value="EFX75082"/>
        <property type="gene ID" value="DAPPUDRAFT_323736"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_323736"/>
    <dbReference type="HOGENOM" id="CLU_1972718_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX75082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="127" mass="14705" checksum="C3C3FB064B1FFBEE" modified="2011-04-05" version="1">MDTLHAASPKRALEELLTNALTTLTAFQYHQKALQKLVDEGMLSLLMKMISALNKIWDENNNISANEVRNISWRAEVAKMLILKLSWLDATPKELLKEKFINILLRRLVLTANRNHFENLTDSFENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0N1</accession>
    <name>E9H0N1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_35627</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732581">
        <property type="protein sequence ID" value="EFX74722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74722"/>
    <dbReference type="EnsemblMetazoa" id="EFX74722">
        <property type="protein sequence ID" value="EFX74722"/>
        <property type="gene ID" value="DAPPUDRAFT_35627"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_35627"/>
    <dbReference type="eggNOG" id="KOG1027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2203508_0_0_1"/>
    <dbReference type="InParanoid" id="E9H0N1"/>
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    <dbReference type="PhylomeDB" id="E9H0N1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="PTHR13954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX74722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="108" mass="12293" checksum="06C50269EDA20925" modified="2011-04-05" version="1" fragment="single">LSSLSPKGILFQATRGLDYLHQNHFVHRNVKPSSFLIKEIQSSNSSNRYAVKITDFRLSRQLDQGKDLSGTVASEGWEAPESRREKQPLHQSLDVFILGCFYHYVLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0Y8</accession>
    <name>E9H0Y8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC2_membrane_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_442567</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732582">
        <property type="protein sequence ID" value="EFX74541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74541"/>
    <dbReference type="EnsemblMetazoa" id="EFX74541">
        <property type="protein sequence ID" value="EFX74541"/>
        <property type="gene ID" value="DAPPUDRAFT_442567"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_442567"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_608688_0_0_1"/>
    <dbReference type="InParanoid" id="E9H0Y8"/>
    <dbReference type="OrthoDB" id="1022017at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC2_membrane_7" evidence="2">
        <location>
            <begin position="349"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX74541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="450" mass="51509" checksum="3F6632E5948BA097" modified="2011-04-05" version="1">MGACDNWDKMVQSSKPTCIFLNQGNPIRKTHSRDLFPFSSNINLQKEMPVCMAFTLEGHVDHNLSMGLCCCWVLYIVDGWVDQWCTDVSWVWRVSNRNAAALLHKTAQKTTTDYYTTKAPEYYTKTYDATSYYTEPRKFRPDGPTGKTRPMDLHFTSLSVSMGKRALLLKEVSGVVQPGKILAVLGPSGSGYPSYRTIHLNGELLNKKLRRKICYVLQHDVVFPDLTLKHTLVGGWFLRGFFWDVNELKFEIHQSESIGIRNPSSVTNVDLFAVRFICSTRRCCACQTTMSYNDKMQQHVSHIIEILDLQRCQDMRAYFRIGRTAHSLMTTLKNYARQEDKTVVLTVLHQPSSQIFCMFDRLLLLCNGQTAYFGDTKKVVDFFKHIGLPMSRTIIRPILSKVKGTAENQERIITSYRETRSDPDLAEQLLMTVGVGGSRWNYKLVPVPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9H341</accession>
    <name>E9H341_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_324904</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732587">
        <property type="protein sequence ID" value="EFX73900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73900">
        <property type="protein sequence ID" value="EFX73900"/>
        <property type="gene ID" value="DAPPUDRAFT_324904"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_324904"/>
    <dbReference type="HOGENOM" id="CLU_1760647_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX73900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="148" mass="16546" checksum="96AE04F58EDBC5A0" modified="2011-04-05" version="1">MLMNKSISLETVDLFARLREQRNKESSIMAESLVPPVKQPKLSFLRKIGILKPPATMKKPSRWARAKAAICNSSSLFAKTLSLFQRKRRTSSRIHDISDNNAPEDLIEVKNQDIVLPTYGNGSTASGLQNCCGEKSAFQFLQFGNAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9H3Q3</accession>
    <name>E9H3Q3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_252891</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732589">
        <property type="protein sequence ID" value="EFX73552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX73552"/>
    <dbReference type="EnsemblMetazoa" id="EFX73552">
        <property type="protein sequence ID" value="EFX73552"/>
        <property type="gene ID" value="DAPPUDRAFT_252891"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_252891"/>
    <dbReference type="eggNOG" id="KOG1302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077782_0_0_1"/>
    <dbReference type="InParanoid" id="E9H3Q3"/>
    <dbReference type="OrthoDB" id="406738at2759"/>
    <dbReference type="PhylomeDB" id="E9H3Q3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007269">
        <property type="term" value="P:neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="SSF56815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX73552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="128" mass="13919" checksum="54065487AAF9B8DC" modified="2011-04-05" version="1">MKSAPYTKLLMDTVKLPGENFQASSHAGQSPRSDGSSVKSVVLNSAEELYADLRDKNFSAVGTALSRKAKAISAHLDNAIVAFGGVKVSAFARDSGEIFLDSFDDSVIMINPDIPDERELREWLKDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9H558</accession>
    <name>E9H558_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_325575</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Andrews J."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <location evidence="2">Cytoplasm</location>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="3">Belongs to the BRI3 family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX72794.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
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                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9HAD5</accession>
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    <gene>
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    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
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    <comment type="similarity">
        <text evidence="1 3">Belongs to the SEC8 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX71290">
        <property type="protein sequence ID" value="EFX71290"/>
        <property type="gene ID" value="DAPPUDRAFT_308944"/>
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    <dbReference type="InParanoid" id="E9HAD5"/>
    <dbReference type="OMA" id="SLPNWTD"/>
    <dbReference type="OrthoDB" id="96167at2759"/>
    <dbReference type="PhylomeDB" id="E9HAD5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032584">
        <property type="term" value="C:growth cone membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="PTHR14146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_exocyst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec8_exocyst" evidence="5">
        <location>
            <begin position="40"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX71290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="929" mass="104738" checksum="411323514F37C8E3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9HAY5</accession>
    <name>E9HAY5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_309222</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732613">
        <property type="protein sequence ID" value="EFX71138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71138"/>
    <dbReference type="EnsemblMetazoa" id="EFX71138">
        <property type="protein sequence ID" value="EFX71138"/>
        <property type="gene ID" value="DAPPUDRAFT_309222"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309222"/>
    <dbReference type="HOGENOM" id="CLU_130064_0_0_1"/>
    <dbReference type="InParanoid" id="E9HAY5"/>
    <dbReference type="OrthoDB" id="1548356at2759"/>
    <dbReference type="PhylomeDB" id="E9HAY5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028996">
        <property type="entry name" value="GM2-AP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357">
        <property type="entry name" value="PTHR17357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="SSF63707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX71138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="130" mass="14082" checksum="136C4827FCCAE559" modified="2011-04-05" version="1">MDLTTTTLIEATAEDNLQIRKVTTRTTDNYEVPCLNGIAGTCTIELCTAIATYPEYVCSLFPNDVPCSCPLAASVYYNPSAYVTFTSEWLAIDGGVNGDYNTRTEVVANLGFANETILGCLDLQYTLVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9HC75</accession>
    <name>E9HC75_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_256839</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732619">
        <property type="protein sequence ID" value="EFX70660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70660"/>
    <dbReference type="EnsemblMetazoa" id="EFX70660">
        <property type="protein sequence ID" value="EFX70660"/>
        <property type="gene ID" value="DAPPUDRAFT_256839"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_256839"/>
    <dbReference type="eggNOG" id="KOG1027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_7_1_1"/>
    <dbReference type="InParanoid" id="E9HC75"/>
    <dbReference type="OMA" id="DMHENIV"/>
    <dbReference type="OrthoDB" id="684563at2759"/>
    <dbReference type="PhylomeDB" id="E9HC75"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="PTHR13954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX70660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="275" mass="31321" checksum="D953DF60EEF9B0AC" modified="2011-04-05" version="1">MEVESNDGTSSSDVVMHYETIGTRESEQRKQILGQGGYGIVYKGLWGEEAVAVKRIQLANTTSSEKGEETLTRLKHPNVIKLLDVETDKYFRYYVLELCQLSLHQLFSGDKNHKQFREKMPSDKEVFLQLAMGLAHIHGMGLIHRDLKPENVLIWVDSTGERVLMKWADFGLSKPVNERGSCSMSGPNRGSDNWYAPEILKMTVEQDEGKLEKKNDEEEDQITPLHQRGTIKSDVFTEGLIFAFYLLKGLHPYGSSRFKIPSNIVEDKPKRKTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCQ4</accession>
    <name>E9HCQ4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_257055</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732621">
        <property type="protein sequence ID" value="EFX70476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70476">
        <property type="protein sequence ID" value="EFX70476"/>
        <property type="gene ID" value="DAPPUDRAFT_257055"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_257055"/>
    <dbReference type="HOGENOM" id="CLU_028498_0_0_1"/>
    <dbReference type="OrthoDB" id="1240237at2759"/>
    <dbReference type="PhylomeDB" id="E9HCQ4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="479" mass="55594" checksum="F9412B72AFE8E295" modified="2011-04-05" version="1">MLRLRNAEEDTTPERDEEHANPPKKRNVESLPLAMSEDLMVLELPLPTLQFAATILESCKVINSLMGKYSNFILKKSEKEDDLVFLILTKETKTEMITEVIDWIGCACFFYGGDEGRRHAYTFWVKAMGLRFTEEGNNIPKKTLSQGLVQRCALKNQNEVESLKDLNSLYLQDDPMLWVFQTFLIGKRVLKKNRLFPDTIIVCKMFEMGLQGWEAKKFDYPYAFAFTVFLIELFGTDEFLKQLVLHPKESQNVVELTFVELFKILQKEDWKKNQTQSDTVLTFDHLMVSLEFLFKYQVLVHDHSPAFPAKKKKQMIMKLIVIVLNLLMPIQKSDYQKRRLVGQLRVYGYNYEKKRIPGQQNLLFGACFRFTGKQNQFDLINVLLEAGSDPNVVDRDGNTPLHHLAKQECSSNAKWNSAQAEKFTALVENILGNLLQPFIKSKRNVYGELALQPFKKKRWPYPNSRFCSLLTQFFENASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HDU5</accession>
    <name>E9HDU5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_113022</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732625">
        <property type="protein sequence ID" value="EFX70111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70111">
        <property type="protein sequence ID" value="EFX70111"/>
        <property type="gene ID" value="DAPPUDRAFT_113022"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_113022"/>
    <dbReference type="HOGENOM" id="CLU_1074636_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX70111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="259" mass="28226" checksum="129ABC44CD073101" modified="2011-04-05" version="1">MYVMRDFQSLVDVGNSESGGGQQPFLASTNSFRRSLRRANSVHSNRKWVVVSFALPHLQSGVAEKLKRCWDLSEFRHFIVPVSVVGDKKKTVQKLASSMIGRGRVCGSKKISAERKAKTLARTAASCGNLPVAARLTDPAIAGFCEMNTTGIRLASILVAEGAKLASSLVAKKLILANLSSLKSRGSSFARTKRASVGAVLKHLVIRRAADRWKDLRAFAMALVLRTVSQTEHPEEMETLEGQSQKFDVGNCSLHTELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9HE84</accession>
    <name>E9HE84_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_13307</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732627">
        <property type="protein sequence ID" value="EFX69973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69973">
        <property type="protein sequence ID" value="EFX69973"/>
        <property type="gene ID" value="DAPPUDRAFT_13307"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_13307"/>
    <dbReference type="eggNOG" id="ENOG502SR1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069291_0_0_1"/>
    <dbReference type="InParanoid" id="E9HE84"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="PhylomeDB" id="E9HE84"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX69973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="318" mass="36350" checksum="059334C008FF9CEE" modified="2011-04-05" version="1" fragment="single">FEYLMVLLQCNSTCIRLVIVYRPPSQSTKCSDGQFLSDFSGFLQLLVVSSGKLLIVGDFNIHVDVAGNSTACKFLTLLDSFGLSQHIRGITHLDGHTLDLVISRISDNVVCECMMSALIEDHFAIHTLIRAHRPVRPQKRITYRELDRIDTDCFMSDLLSLSLFTDPSDDLNILLEQYNADLSLLLDKHAPERSKVITVRPANPWVSTDVLAIRRRCRASERRWRNRKKKGLALEIDREIVRNLLKEKRHLLKKEKSSFLNEKIAEAEGKKSLFNIVDSFLLKKPGLKLPRHDSLPDLVSRFSDHFLKKVTDIRASLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9HF70</accession>
    <name>E9HF70_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_202764</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732634">
        <property type="protein sequence ID" value="EFX69559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69559"/>
    <dbReference type="MEROPS" id="M41.A11"/>
    <dbReference type="EnsemblMetazoa" id="EFX69559">
        <property type="protein sequence ID" value="EFX69559"/>
        <property type="gene ID" value="DAPPUDRAFT_202764"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_202764"/>
    <dbReference type="eggNOG" id="KOG0734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_19_2_1"/>
    <dbReference type="InParanoid" id="E9HF70"/>
    <dbReference type="OrthoDB" id="217929at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="10">
        <location>
            <begin position="290"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="648"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX69559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="697" mass="76828" checksum="881A6EB0583BABF9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9HFZ6</accession>
    <name>E9HFZ6_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_113753</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732638">
        <property type="protein sequence ID" value="EFX69303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69303"/>
    <dbReference type="EnsemblMetazoa" id="EFX69303">
        <property type="protein sequence ID" value="EFX69303"/>
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    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_113753"/>
    <dbReference type="eggNOG" id="KOG0393">
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    <dbReference type="HOGENOM" id="CLU_460983_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HFZ6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX69303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="592" mass="64840" checksum="E4A38E40D7CA89BD" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_301001</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
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            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732639">
        <property type="protein sequence ID" value="EFX69248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69248">
        <property type="protein sequence ID" value="EFX69248"/>
        <property type="gene ID" value="DAPPUDRAFT_301001"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301001"/>
    <dbReference type="HOGENOM" id="CLU_2833738_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Krijgsveld J."/>
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                <person name="Manak J.R."/>
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                <person name="Tsuchiya D."/>
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                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Eads B.D."/>
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                <person name="Tsuchiya D."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Rogozin I.B."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="72" mass="8018" checksum="96D3C31EAC55E61F" modified="2011-04-05" version="1">MPPFPPFPTDDDNVYEDMYMYEYCDTGNLRGKDNPMKVTPEGEVSTGGDYETPNPPLGKPNFPPPHVPDSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732668">
        <property type="protein sequence ID" value="EFX67766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67766">
        <property type="protein sequence ID" value="EFX67766"/>
        <property type="gene ID" value="DAPPUDRAFT_330700"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_330700"/>
    <dbReference type="HOGENOM" id="CLU_2576246_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="81" mass="9668" checksum="39CF1BBE238A094D" modified="2011-04-05" version="1">MVQKYDEINRKKMDPAYISIMSILEVFEKLRKDFLPRSRLQKEYQDFVPLLSAFRAWLISFSTDSTPLIMDNSSKNFQLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E9HKV8</accession>
    <name>E9HKV8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransf_21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_301984</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732673">
        <property type="protein sequence ID" value="EFX67629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67629">
        <property type="protein sequence ID" value="EFX67629"/>
        <property type="gene ID" value="DAPPUDRAFT_301984"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301984"/>
    <dbReference type="eggNOG" id="ENOG502RZ16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062907_0_0_1"/>
    <dbReference type="InParanoid" id="E9HKV8"/>
    <dbReference type="OMA" id="WANDIIF"/>
    <dbReference type="OrthoDB" id="766741at2759"/>
    <dbReference type="PhylomeDB" id="E9HKV8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_21" evidence="2">
        <location>
            <begin position="121"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX67629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="297" mass="34451" checksum="74ADDB15E974733E" modified="2011-04-05" version="1">MRRSTFAKGRPVALMTVLSVGFTLFFFRYCYLESSELNISNYISQFFLASICDIDYINSAKSALEQDDPCILRIIREKFLFPPSQNRLHLYDQRNHNPSQGQADVILDVLKHQKNGFFVECGALDGEQRSNTLYMELDLEWQGVLIEGDLKNYKKVLKKNRRVWTVPACLSTSPYPKTVVFNQALNLGRMSQNETIDEKREESVLVQCFPFFSILSALDRTQIDYFSLDIEGDEFTVLKTIPWDRVDIKTLSVEIAHDREDKKTIRAYMEQKGYDIVAPYPEEGDTVGNDFIFKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HL87</accession>
    <name>E9HL87_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_115408</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732677">
        <property type="protein sequence ID" value="EFX67458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67458">
        <property type="protein sequence ID" value="EFX67458"/>
        <property type="gene ID" value="DAPPUDRAFT_115408"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_115408"/>
    <dbReference type="HOGENOM" id="CLU_1779306_0_0_1"/>
    <dbReference type="OrthoDB" id="1343623at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="146" mass="15960" checksum="2802FA6F5FED202A" modified="2011-04-05" version="1">MKLKQLLSLGVTKNLVRFSKANKKATLEITSKGLVTLIMESLPQSHRHEKIGLSVRYSRKIVHFKEYFINGAPLGSVGSANKSGWICQTKISICSSSRPTTPANITSGCRVAGLVPFNRFIFDGDVDFAPSFVTDRPFNSSPVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLF4</accession>
    <name>E9HLF4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_261673</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EMBL" id="GL732678">
        <property type="protein sequence ID" value="EFX67430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67430"/>
    <dbReference type="EnsemblMetazoa" id="EFX67430">
        <property type="protein sequence ID" value="EFX67430"/>
        <property type="gene ID" value="DAPPUDRAFT_261673"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_261673"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_9_1_1"/>
    <dbReference type="InParanoid" id="E9HLF4"/>
    <dbReference type="OMA" id="TMEEMFS"/>
    <dbReference type="OrthoDB" id="113272at2759"/>
    <dbReference type="PhylomeDB" id="E9HLF4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030330">
        <property type="term" value="P:DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="InParanoid" id="E9HNP1"/>
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            <end position="168"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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    <name>E9HNU4_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX66589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="91"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX66589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="254" mass="28929" checksum="0C1DB0DA12DC9573" modified="2011-04-05" version="1">MKECEDTAVTDDGDPQVEYDSHRGKLRTKIKSASVREKDGGKYEDELKEEIEQRLGDSEEFRMVKYDESDESDGEDESNEFDGNDRDEIVSLNESENGQVEEDQEVNREATSYPEEMNEAQQDVVQFFMLIFMLILKIMKDKSAKTKAKSAKWNTKNRLNTNLLHLLIPSQPKLAQACGEVDDNDTVIEHIHTSYSVHYSADSNNEVNLTEDDNANQEPQGKDNKDVIEADADDRSLYLSLRGRKLHVCLVGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HP72</accession>
    <name>E9HP72_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_116377</name>
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    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Rho M."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="114" mass="12379" checksum="A1068EFBACB9AE9A" modified="2011-04-05" version="1">MSSPLNQPGSPGMLRRSNMGQQGSPVMLRRSMSGSSGLNNLSHSGSFVRRNNDRDGMGNNVGVSPGGNNAAYRASLVSHYAEDLDRRRRAERAVEEIRTDGSSTFDFTFSAKKL</sequence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="204" mass="22999" checksum="6EECABCD5DD4E229" modified="2011-04-05" version="1">MTVRGEERGAVVSSDNKTCLAAGRRFVSLKTNIEQAIERAALAIEVDCGRAQALADQLRTEFIELSEKSDFLGSAFRIDCRGEYEDCDNEELNKFREACSANHDTKLTPHDTIHQPGGIAGLNLNKDYSVFYNYKDYSKIFPGWKDPRIDEEMPVREYILATYNKQIAEKYKLKPSTNIPASYSRNLSSIKEQLEGEIAGTKSN</sequence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <feature type="non-terminal residue" evidence="2">
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HSI5</accession>
    <name>E9HSI5_DAPPU</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="3">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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    </evidence>
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        <source>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Basu M.K."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="EMBL" id="EFX61518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="285" mass="32663" checksum="9375E3D58B1934CF" modified="2011-04-05" version="1">MFVLRMLLLLGLYALGLNALEITVCDCEQASQKGILQFSDEDCQPEKNENRTNAVNYSVYTEKREELKFPGYICARWKQIKHITTSFFGQKVVVPDTIALETSPLECLTMYESRRCREQPMTINDKKFFYDQEPVEDGWWLETVTVETINCAVEKIQLYQETEGESFSTPLGIAPATAGSISHNHLTLIWDKTFTVKSEPKARLVESGVAIIITTGTSNKFRMHDEEKELEFHIQITNKSCQSGMFLPLFSICKHLYLAFCTRVYKLPVPSCVPRVIRVELCVEF</sequence>
</entry>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_339198"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_644459_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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    </feature>
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        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX61507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="426" mass="45413" checksum="ADC8D8F03454ABCB" modified="2011-04-05" version="1">MTQVPPNASITHSASLPNLLDEHRYSNVTVPGGPTVKNQGIEPTTSRFSPGDAAEPKATPDVNHSELPTTERGVIQLSTCANCFDNLKFGVATRQCLAKTCLAKNCLAKMSKSMSSQEVRVVREPRIGGTSSGPVTSPHEDLKKLSDTDRAFLDPHRADLLSLRGSSGSHPRVSIVPGAALVRGGANIRPEVSTYSGHDTPDTDTSAIGSSRSRKVRESIHNPEDGVPQASPGAYRVSDNSDSPASEASNVLGITGHDILKIAEEMKTLSKTQEQTEHSGIQSVSSSGNDPTIEPMSAENQSCPLAPSRIDPTLSNLESKSRGRTLSRASKAKFSPLPVHITHTINGNESTVNLATPESEEHQPPVPEFDSKGQATNLMPAQQALRHRITSKVMAAQNWFNVKKSVVSEPLEVATPLVAPDTPVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E9I3G3</accession>
    <name>E9I3G3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_121798</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
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                <person name="Detter J.C."/>
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                <person name="Arnold G.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Yamada T."/>
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                <person name="Andrews J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
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    </protein>
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    </gene>
    <organism evidence="6">
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
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        <property type="gene ID" value="DAPPUDRAFT_73053"/>
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    <dbReference type="PhylomeDB" id="E9I7L7"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
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        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX60013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="145" mass="16415" checksum="83991BB0F62C50A5" modified="2011-04-05" version="1">MSETKNSLVQCFGRKKNSVAVASVRAGKGVLRVNGSPIELLEPQSLRAKVLEPILLLGLKRFQSLDIRIRVRGGGYVSQIYAIRQALSKGVVAYYQKYVNETEKREIKELLLQYDRSLLVADPRRCEPKKYGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9FQS6</accession>
    <name>E9FQS6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transformer-2 protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_299504</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90042"/>
    <dbReference type="EnsemblMetazoa" id="EFX90042">
        <property type="protein sequence ID" value="EFX90042"/>
        <property type="gene ID" value="DAPPUDRAFT_299504"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299504"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050438_3_0_1"/>
    <dbReference type="InParanoid" id="E9FQS6"/>
    <dbReference type="OMA" id="YEERDYR"/>
    <dbReference type="OrthoDB" id="1524134at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="117"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX90042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="259" mass="29183" checksum="50B808C1963A821B" modified="2011-04-05" version="1">MDSPRRKDSPSGNYRHHKDSGRSRSPGHRHQARRSRSYDEDRDRRSHHDRRDRGDRGGDRGGDRYHSRSRSPMSGRKRHNNMHGGSHRGGGGGGGGGGGGGGGGGGGGPPDNPEPTRCLGVFGMGLYTTETELQHVFAKYGPLEKVQVVKDAKTGRSRGFAFVYFESLEDAKLAKEQCTGLEIDGRRIRVDYSITQRPHTPTPGIYMGRPTITSGRYDKYDRNERGYRRSPSPYYEKNYRSSRRGYERSRSRSYSPRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRT1</accession>
    <name>E9FRT1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Muscle-specific actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ACT2A</name>
        <name evidence="2" type="synonym">ACT2B</name>
        <name evidence="2" type="ORF">DAPPUDRAFT_347736</name>
        <name evidence="3" type="ORF">DAPPUDRAFT_347739</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX89901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="E9FRT1"/>
    <dbReference type="STRING" id="6669.EFX89657"/>
    <dbReference type="EnsemblMetazoa" id="EFX89657">
        <property type="protein sequence ID" value="EFX89657"/>
        <property type="gene ID" value="DAPPUDRAFT_347736"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89901">
        <property type="protein sequence ID" value="EFX89901"/>
        <property type="gene ID" value="DAPPUDRAFT_347739"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_347736"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_347739"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="OMA" id="NILPICC"/>
    <dbReference type="OrthoDB" id="649708at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="PTHR11937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX89901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="376" mass="41788" checksum="006D85567C0EDC78" modified="2011-04-05" version="1">MCDDDVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNCPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETVYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSL3</accession>
    <name>E9FSL3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_232881</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
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</entry>
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                <person name="Basu M.K."/>
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                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    </evidence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="16" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Kultz D."/>
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                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89534">
        <property type="protein sequence ID" value="EFX89534"/>
        <property type="gene ID" value="DAPPUDRAFT_310601"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_310601"/>
    <dbReference type="HOGENOM" id="CLU_1837103_0_0_1"/>
    <dbReference type="OrthoDB" id="1357584at2759"/>
    <dbReference type="PhylomeDB" id="E9FU48"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="140" mass="15953" checksum="5A54102B8D57EB12" modified="2011-04-05" version="1">MAQSILQICKLSSKTIQNQGISICKTHSNPQQRKPAEGKARKTCQKEVGPIPSNDNLQKERHTHPQQRQPAKGKARKTCQKEVGPIPRNFNLQKERAVRLSFTFEGHGDHYIKRVMQWCRGWVRTGRVSSFSSSCNSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9FU59</accession>
    <name>E9FU59_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_303071</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89527"/>
    <dbReference type="EnsemblMetazoa" id="EFX89527">
        <property type="protein sequence ID" value="EFX89527"/>
        <property type="gene ID" value="DAPPUDRAFT_303071"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303071"/>
    <dbReference type="eggNOG" id="KOG1628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062507_0_1_1"/>
    <dbReference type="InParanoid" id="E9FU59"/>
    <dbReference type="OMA" id="GQNAYTK"/>
    <dbReference type="OrthoDB" id="1207239at2759"/>
    <dbReference type="PhylomeDB" id="E9FU59"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_S3Ae_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_S1/3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_S3Ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_S3Ae_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX89527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="267" mass="29690" checksum="5E3A0061D68B0FA7" modified="2011-04-05" version="1">MAVGKNKGLSKGGKKGLKKKIIDPFTRKDWYDIKAPSMFAVRQVGKTLVNRTQGTRIASEGLKGRVFEVSLTDLQNESDSERAFRKFKLISEDVQGRNLLTNFHGMDMTTDKLRSMVKKWQSLIEASVEVKTSDGYLLRVFCIGFTKKEAESTRKTCYAQHAQIKSIRKKMVDIITREVGSVDLKEVVSKLIPDSISKDIEKSCQGIYPLHDVNIRKVKVLKKPKFDIGKLLELHGDGGKSGVGGEGGVSGSVDRPEGYEPPVQESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9FVC2</accession>
    <name>E9FVC2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_233641</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88532">
        <property type="protein sequence ID" value="EFX88532"/>
        <property type="gene ID" value="DAPPUDRAFT_233641"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_233641"/>
    <dbReference type="HOGENOM" id="CLU_3089341_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX88532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="52" mass="5988" checksum="D6278A756CDF763D" modified="2011-04-05" version="1">MFKNHDFYPILRAMNFQNLDAHQSAGNQNDMGEAFLNDPEVVFQIKAKAMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9FVI1</accession>
    <name>E9FVI1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_310779</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
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            <dbReference type="PubMed" id="21292972"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_233890"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="93" mass="10171" checksum="3EF238DD79EB83FE" modified="2011-04-05" version="1">MFPVILTRGEETAAEMRIRVGSMMAALMNCGPSSLIQQVFGQQQNDCAQFVIRFVFFATTVPAARPAAGQLPFTNNTKDPHNLSSLELMGYST</sequence>
</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Lucas S.M."/>
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                <person name="Zdobnov E.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732525">
        <property type="protein sequence ID" value="EFX88658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88658">
        <property type="protein sequence ID" value="EFX88658"/>
        <property type="gene ID" value="DAPPUDRAFT_233924"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_233924"/>
    <dbReference type="HOGENOM" id="CLU_2640626_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="10564at6657"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="257" mass="28690" checksum="DFD4C20121D794E5" modified="2011-04-05" version="1">MFTTLGTILLNGLNSKSAKEYHRHIEHLLVCVLRVLLYTAQPSQKESHLNLMQILKLALDSKFLTPVQLDATDFLSTPGVAASPQQIALLRVIANLFCETTASRSFLVQLCALRAFELFFKTTPHSQLASSCIREGKDFFVKQFINRKTTKPLIGEASLLYSSQLKCLTNPPRHVNSFPKLSIEAYALLAADSLDHGAEPYSNGSIAKRPRLDNTDQLPFMLNSLAKIVADIGQLGPLPMWSKEEIKERINTLNSYM</sequence>
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    <accession>E9FXV4</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88227"/>
    <dbReference type="EnsemblMetazoa" id="EFX88227">
        <property type="protein sequence ID" value="EFX88227"/>
        <property type="gene ID" value="DAPPUDRAFT_311771"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_311771"/>
    <dbReference type="eggNOG" id="ENOG502QTTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100749_0_0_1"/>
    <dbReference type="InParanoid" id="E9FXV4"/>
    <dbReference type="OMA" id="VWYEYLF"/>
    <dbReference type="OrthoDB" id="1268983at2759"/>
    <dbReference type="PhylomeDB" id="E9FXV4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="205" mass="24294" checksum="28712066C019BA9F" modified="2011-04-05" version="1">MPDILLVSDQEKRIKSLKRRIETWRVFLVALYSVLIWTESWYPCPIVGTISTVFLMYWYWNPPIITSVSLFFMMLSLFDYSVPRICSCISQPHQWTALNEKKFEIICETLVKTQDKIYNQMTYFIDLKRTNPKMYFLSLFSFCSLSAWIGYTVNNWLICFILVTLISLYPGVKHNEVLSKFLSIFLHRVTNGIRSYTEKDSVKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9FYL7</accession>
    <name>E9FYL7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_312020</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732527">
        <property type="protein sequence ID" value="EFX87552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX87552"/>
    <dbReference type="EnsemblMetazoa" id="EFX87552">
        <property type="protein sequence ID" value="EFX87552"/>
        <property type="gene ID" value="DAPPUDRAFT_312020"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_312020"/>
    <dbReference type="eggNOG" id="KOG1052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007257_4_0_1"/>
    <dbReference type="InParanoid" id="E9FYL7"/>
    <dbReference type="OMA" id="MEYGIVM"/>
    <dbReference type="OrthoDB" id="188544at2759"/>
    <dbReference type="PhylomeDB" id="E9FYL7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004970">
        <property type="term" value="F:ionotropic glutamate receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="5">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Lig_chan-Glu_bd" evidence="6">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX87552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="426" mass="47574" checksum="951045D542C7D7E9" modified="2011-04-05" version="1">MKEPPFVIFDRDPNGTVVGYKGYCYEIVRILQQQYNFTYEIILPGDNAFGKELHDGSWSGMIGMVVAQRVDIGLGPFSVTHSRSKVVDFSVSFYEDGNAILIPPAAEENRLSACTKPFRLETWLTLMLFATLILPVILWQHSKFYWIHYREKCPTLGDQYLFILGVLIGQSGRKLSSRCSLQLLAAIWCLSAVVFASAYVGILMSFLRFPKLLPVINRLEELPESHLKWVALRGTALDSLFLDATAGIYKTIGDGLLKQQRGALIDVHLDGITLVANGGYAYLAGKSNLESSLYEDYLRTGTCRLSIAQQEFFKVNVAFAFSKNSALKPFMDEKILQMMEAGLDIYWKKLYGAPTGGKCGKLFAVLLAMMAIVYTNSLPTAEEGEETDQTFCKPFSSCTNSTDCSSNLIYKTCRANLFGNKQCCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9FZP4</accession>
    <name>E9FZP4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C1q and tumor necrosis factor-related protein-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_221816</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87232">
        <property type="protein sequence ID" value="EFX87232"/>
        <property type="gene ID" value="DAPPUDRAFT_221816"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_221816"/>
    <dbReference type="eggNOG" id="ENOG502QT1U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068539_0_0_1"/>
    <dbReference type="InParanoid" id="E9FZP4"/>
    <dbReference type="OrthoDB" id="1258047at2759"/>
    <dbReference type="PhylomeDB" id="E9FZP4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="SSF49842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003240483" evidence="2">
        <location>
            <begin position="24"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="3">
        <location>
            <begin position="160"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX87232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="306" mass="33818" checksum="860E89B314DEC3F4" modified="2011-04-05" version="1">MATVRIHFCFLVLTCFWTGAVFSLEDQSSQQLRDSHNQFQKFMEATVSRLEALEQEQSKMKEDSAAIIMQLEAKVQQQEILLVALLKSDQPSSGSKSVPAESRAATRAMPTSCADLKSTGHIWNGVYSVIGATTVETVYCDFTKPNTDSGFQTFVGYAGVQSKPTYFYGQLNYNWYLTGTPIAYDTFVLNEGGAYDRTTKKFTAPVAGRYFFSFTGRAQSYNPPADFRLEVEMVKNGQYVARAAADDGANSETLSLQSILNLKAGDQVWTQATYITSGISLLGPDYTHFTGFLLEEDVALSLKAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9G0A3</accession>
    <name>E9G0A3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_235601</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
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    <dbReference type="PhylomeDB" id="E9G1F5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031849">
        <property type="term" value="F:olfactory receptor binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026096">
        <property type="entry name" value="R-trans_p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="Znf-3CxxC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14402">
        <property type="entry name" value="PTHR14402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13695">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-3CxxC" evidence="1">
        <location>
            <begin position="152"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX86492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="291" mass="33417" checksum="528F6F7DB40232C2" modified="2011-04-05" version="1">MSFSHHSTEFSDAEFESSSDSGLSVESFEISSELAVFSHRVIGIFLPLSSVELVPIQLPCYPSSKDKSSHHQVNKVQFNHRLIKWSLPPPSTPPVPLPGWNAMPYGLETFWQSAFCWFFRPFVAAHGHLWTLEPTELPPLSVEWPWHSTSFSAKVRFQCKCTRGWTSMKGRVSFWFRIRRQGDQVLCEALFKLFGQKCNICNQPDSFNESEFLTPLWYPEEIENAIRLLASHVSMSYYGEQRNAQDIYNIVRIRHSQPRKKSLAVHHHPIRCQACLYGSCATISLSNTCKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E9G1Z3</accession>
    <name>E9G1Z3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_307870</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732529">
        <property type="protein sequence ID" value="EFX86575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86575"/>
    <dbReference type="EnsemblMetazoa" id="EFX86575">
        <property type="protein sequence ID" value="EFX86575"/>
        <property type="gene ID" value="DAPPUDRAFT_307870"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307870"/>
    <dbReference type="eggNOG" id="KOG0040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_589592_0_0_1"/>
    <dbReference type="InParanoid" id="E9G1Z3"/>
    <dbReference type="OMA" id="CDEMENT"/>
    <dbReference type="OrthoDB" id="543832at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Spectrin/alpha-actinin"/>
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        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
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    </dbReference>
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        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX86575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="464" mass="53902" checksum="0A56771E33E9B9B7" modified="2011-04-05" version="1">MGEIMSPKEMAGQEQLVEFQHLCDQMMFWINYKEVIVWPEDLKSEKDSQLIMKQKYAKFNEEVAAQESHVNDVMKLADLLIESKHPDEIVIRRRREELKQSWQRMRKLALKRQMLGQEELAGAQPMEVIQPEDGKKPTLQSVATEAKLLRGLLEDFLRLEQFEKDCHPTKTWINETIGLMSDDGHLSPTDLNLKMDNHKKLEEDVMSRKNRVEMLTKIQAHLTDVLKMWEVLLAATELKSIHMSQAWQLEKFNHGIDNMTVWLAEVEATLSSPDFGSDLASVELLTKEHALLERDIKTHKDIIDIIVTAAQQFSECGHFDLKNILSKKDVVVKRFDGLGPLQSERQRKLVDALKAYQLFHEMDVEEEWIAKKHEVIAGRGKDIDTVRALIKETQSILQAMQIHDPDVQRVIQSGQKLARGHHLAEEINKRTQQLSEHWTSLKERAFERKQSNQLVLLFLFQIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9G249</accession>
    <name>E9G249_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pepdidase_M14_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_222178</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732530">
        <property type="protein sequence ID" value="EFX86184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX86184"/>
    <dbReference type="EnsemblMetazoa" id="EFX86184">
        <property type="protein sequence ID" value="EFX86184"/>
        <property type="gene ID" value="DAPPUDRAFT_222178"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_222178"/>
    <dbReference type="eggNOG" id="KOG3641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007523_4_0_1"/>
    <dbReference type="InParanoid" id="E9G249"/>
    <dbReference type="OMA" id="TGSAICY"/>
    <dbReference type="OrthoDB" id="481670at2759"/>
    <dbReference type="PhylomeDB" id="E9G249"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035609">
        <property type="term" value="P:C-terminal protein deglutamylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035610">
        <property type="term" value="P:protein side chain deglutamylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pepdidase_M14_N" evidence="2">
        <location>
            <begin position="51"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX86184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="509" mass="58752" checksum="3DE31B9E31A88823" modified="2011-04-05" version="1">MVLNPNSYRPEVVYDLDSLLLDAEQTQSIRMEDFEAASKHRISQPNAPLEFESRFESGNLRRAIRIGSHEYDLILNADVNSFGRQQWFYFRISGEGVCSSKSYTFNVINLEKQRTLFHQGMQPLMFSVKRYMVTRTQPVWERSGTSMCYYRNGFRQSNAEQTSYWSLSFTVTVPYDNDVLYIAYHYPYTYSQLMTDVVTWLRTPFPIGYPSYSMDRLRISTLCRSPCGNPVPLLLIDYDGDAQSCCVFMSRVHPCESNSSWSMRGLVVTALQDMTQSDERHHPLFILPMLNVDGTVHGCSRTELSNEDLNRRWLTPNLHHHPTIYHAKGLLEFICRILDAKPAVLCDMHGHSRRFNAFVYGCKGSQSWCPDDWSQKDAQGDHPTMKKLKDENGDDDDTTSLPFFVQLMQAQSPLFDTNQCCFEVEKNRETTARIVGWRHLGIKNIYTLECSLAGSNQLPLQGLQHFNTANYFQVGKALMKYIHELNIDRSTEECDMQNAIFILTFNILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9G5D5</accession>
    <name>E9G5D5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_208848</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Geiler-Samerotte K.A."/>
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    </evidence>
    <sequence length="620" mass="71070" checksum="5A94503F0263D409" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8L4</accession>
    <name>E9G8L4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate carrier protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_230626</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84247"/>
    <dbReference type="EnsemblMetazoa" id="EFX84247">
        <property type="protein sequence ID" value="EFX84247"/>
        <property type="gene ID" value="DAPPUDRAFT_230626"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_230626"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_3_1_1"/>
    <dbReference type="InParanoid" id="E9G8L4"/>
    <dbReference type="OMA" id="KFFFFEY"/>
    <dbReference type="OrthoDB" id="963446at2759"/>
    <dbReference type="PhylomeDB" id="E9G8L4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031305">
        <property type="term" value="C:integral component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="Mitochondrial_sb/sol_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="Mt_carrier_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="PTHR45671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="SSF103506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="51"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="148"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="249"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX84247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="351" mass="38130" checksum="F86FBA384D628E0B" modified="2011-04-05" version="1">MNSLWEAAKKSPFLTSANCEAKMTTDNQLVANRTIAAAAAETYSCEYGSSKYYALCGVGGLLSCGITHTLVTPLDMVKCRIQTNPAKYKSIVTGFKVSVAEEGMRGLVRGWAPTAIGYSAQGVCKFGFYEAFKIVYANALGEENAYVYRTGLYLAASASAEFFADIALSPMEACKVRIQTMPGFPATLRAGAPLIYQQEGLNGFYKSLVPLWMRQIPYTMMKFACFEKTVELLYKHVVPKPRDQCTKGEQLVVTFAAGYIAGVFCAIVSHPADTVVSKMNAVKGSTAGDTLKKLGLMGVWQGLTPRIIMIGTLTAAQWFIYDAVKVWLGLPRPPPPEMPESLKAKLAAAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9G8W3</accession>
    <name>E9G8W3_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PA2c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_301339</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732535">
        <property type="protein sequence ID" value="EFX84200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX84200"/>
    <dbReference type="EnsemblMetazoa" id="EFX84200">
        <property type="protein sequence ID" value="EFX84200"/>
        <property type="gene ID" value="DAPPUDRAFT_301339"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301339"/>
    <dbReference type="eggNOG" id="ENOG502S31M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_970637_0_0_1"/>
    <dbReference type="InParanoid" id="E9G8W3"/>
    <dbReference type="OrthoDB" id="1422829at2759"/>
    <dbReference type="PhylomeDB" id="E9G8W3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonic acid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLipase_A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLipase_A2_His_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="SSF48619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013243353" description="PA2c domain-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="PA2c" evidence="4">
        <location>
            <begin position="106"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX84200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="287" mass="32164" checksum="FFB2DD15FA4F14AB" modified="2011-04-05" version="1">MILIIVLSLLQAIVALVSNSTGSNELFVLDGHPRGRRAVLVNSDPNEPCRIYGHSNPIQVIENLPDGPRLRTINQQEWLTIAADCQQRLLTLNQKPTTASNQIDFIYPGTKWCGTGDVANNFKDLGPHAATDMCCRDHDFCSNTMKPGTCKYGLCNTSVFTKSHCDCDDRFRQCLLNAANDPASVPVGFIYFDVGFISCYRQTPDCVNKVFREPIELTRRKKRQYQSRTRNLQNGWCFIPPQPFKKSAMVRRNQPDGIFRHVLSTMSDVSTMVKQVAGSTLSVQSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9G9Q9</accession>
    <name>E9G9Q9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_301623</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732536">
        <property type="protein sequence ID" value="EFX83613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX83613">
        <property type="protein sequence ID" value="EFX83613"/>
        <property type="gene ID" value="DAPPUDRAFT_301623"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_301623"/>
    <dbReference type="HOGENOM" id="CLU_027459_0_0_1"/>
    <dbReference type="InParanoid" id="E9G9Q9"/>
    <dbReference type="PhylomeDB" id="E9G9Q9"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX83613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="359" mass="40786" checksum="7C9365F915EF0F72" modified="2011-04-05" version="1">MHKIPNFFRKPKTQEGDSVVSPTKQILTPEELEKLKNKIKTEISTAEIRIQYLLNRTTRPKERDPEEIETLENDIKSLKAKYAELIDPTVTIYKRKKQVVEQSDRASSQGPDKPNPPKVAPAKSPVVTLFDSIDEIEEGATALPTQVKQRTTECANRTHSNTRCMDRRAKATFLQERMSKSAANFNDSLTAAEKATYAVWKQALLDGLTDNTTKARKKEQLKTLKQKATERVRDFKIRIDDTYRIAYGVNAATSRHADVVALRNETLKDVLLNGLKPQIADLVWNRPNLNDKTYPETVESAEECEKVVEMKKITENKDLSTAIMLAAKESKEMSEEVNNLKLLLQKLESMSVNQQKAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9GAM4</accession>
    <name>E9GAM4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphopyruvate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ENO</name>
        <name evidence="13" type="ORF">DAPPUDRAFT_347595</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="GL732537">
        <property type="protein sequence ID" value="EFX83276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX83276"/>
    <dbReference type="EnsemblMetazoa" id="EFX83276">
        <property type="protein sequence ID" value="EFX83276"/>
        <property type="gene ID" value="DAPPUDRAFT_347595"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_347595"/>
    <dbReference type="eggNOG" id="KOG2670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_0_0_1"/>
    <dbReference type="InParanoid" id="E9GAM4"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="OrthoDB" id="773373at2759"/>
    <dbReference type="PhylomeDB" id="E9GAM4"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="142"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="371"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX83276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="433" mass="46799" checksum="AE215A5E06198999" modified="2011-04-05" version="1">MSIQKIFARMIFDSRGNPTVEVDLTTEKGLFRAAVPSGASTGIHEALELRDDIKTEYHGKGVKKAVSNINDLIAPALLKENLQVTDQEAIDNFMIKLDGTENKSKFGANAILGVSLAACKAGATHKGVPLYRHIADLAGTPEIILPTPAFNVINGGSHAGNKLAMQEFMILPTGASSFTEAMRMGTETYHHLKKVINARFGLDATAVGDEGGFAPNILNNKDALDLITSAIEKAGYTGKIEIGMDVAASEFHKNGKYDLDFKNPASDPATYLESNKLAELYQEFIKDFPMVSIEDPFDQDDWAAWTSLTGNTPIQIVGDDLTVTNPKRIQMAVDCKACNCLLLKVNQIGTVTESIAAHKLAKANGWGTMVSHRSGETEDSFIGDLVVGLSTGQIKTGAPCRSERLAKYNQILRIEEELGAAAKYAGKNFRHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9GCG6</accession>
    <name>E9GCG6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_316299</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="435" mass="49022" checksum="DD5E90F0C8874E71" modified="2011-04-05" version="1">MNSLFTKKNDVQFYPWLCSRAELRAELPKVNQSCTPTQTPKQRSQKTTSAPRRQGKQIQEAVQEERQEKEIVDTEQQEPKQPQVGEEESDGFSSTAYEESAKGEDEESDKDEDDEESPKDQDEVYKGHSENLEQLDPIQVPISAQENDSRGDDPDDSMRVAVIDAELLNYVTVDESTLVEPLVMETTTEQDGTIVYRFSPEELAALTGREKDMRVPVSVARLLISYKQEIVGLKSLMARVLEKLDILTSQNRKSNSGEDTFDILSTRFKLPLKTRKALMELDAELDNNMELKQQIQLALSLLGGKNLKEIVRLTMRGLMAKEVRVKYVAQKVTKGKHVFKHHKNLFGFIIDVVRLGLDREKLPAATQQDIVHQIGLLFTGSGDEDGGVVARKRKKAMEQAVLDKHFKNRTNARENNAIGEDGSDSSLNDSGDVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKL1</accession>
    <name>E9GKL1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_244276</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732549">
        <property type="protein sequence ID" value="EFX80010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80010">
        <property type="protein sequence ID" value="EFX80010"/>
        <property type="gene ID" value="DAPPUDRAFT_244276"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_244276"/>
    <dbReference type="HOGENOM" id="CLU_1769937_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="147" mass="16716" checksum="5E311A52F4C892EC" modified="2011-04-05" version="1">MDQELRPFLNGNLVIEENILEPLQGNKENSSEEHPQNLVMENFLGEPQQTPLSDKEGTEEDSCEEQPPNLENSAVQRDKTPLQDEGGNLINDTQLTTPNDATPETFIHDSKAHSRGNATTTDNMEVRDSVKSPRLQREEMEVFYHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9GL91</accession>
    <name>E9GL91_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3Beta_HSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_319286</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732550">
        <property type="protein sequence ID" value="EFX79835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79835"/>
    <dbReference type="EnsemblMetazoa" id="EFX79835">
        <property type="protein sequence ID" value="EFX79835"/>
        <property type="gene ID" value="DAPPUDRAFT_319286"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_319286"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_1_1"/>
    <dbReference type="InParanoid" id="E9GL91"/>
    <dbReference type="OMA" id="KIGGSHI"/>
    <dbReference type="OrthoDB" id="930591at2759"/>
    <dbReference type="PhylomeDB" id="E9GL91"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003854">
        <property type="term" value="F:3-beta-hydroxy-delta5-steroid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="3Beta_HSD" evidence="3">
        <location>
            <begin position="10"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX79835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="373" mass="41874" checksum="61E3A81615AD67D6" modified="2011-04-05" version="1">MCSEHSYTFLITGGAGYIGFHIGLQLLQLKHKVILLDINYPNKKWDFNLEFSPNGNGEEMEDISCSYGTMKFVKGDVRDISILLRATQGVTCVIHTVGYGMSGVQQMPSHLHLVEEININGTRNVIEACAKNNCRGLVYTSSNSVVFGGHPIFNGDESLPYYPLHKQSNHYSKTKTIAEQLVLTSNGRGDLQTCALRLAGVIGRGEMRGLPRTVWSIRNGLLAFKYHDQHGGLTDFMGIDNAVQGHVKAALKLVDPDRKTPGIGGQAFFLSDGRPISFFDYIKPIYEYYGQPFPAIRVPIWLMNFFVFLIMFACSLWSALFFECVPYLNSCELEVSSMTHYFSIDKARKELDYHPLKPNDISDVIDGLSENEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GLW9</accession>
    <name>E9GLW9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_104318</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732551">
        <property type="protein sequence ID" value="EFX79621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX79621">
        <property type="protein sequence ID" value="EFX79621"/>
        <property type="gene ID" value="DAPPUDRAFT_104318"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_104318"/>
    <dbReference type="HOGENOM" id="CLU_1350116_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX79621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="203" mass="23654" checksum="E05DF16AD00B8CF0" modified="2011-04-05" version="1">MVTPSVRQDRCMEFVKQNVAFWCEQSSQQVLVLFWSKLFLSMWVLGCGRRDFNVLTSCFLIIQLNCKLASTRTQLQEPELQTKATMVYLKTVQRWLSKKGGGYQGMRQCSRGGRRQECSRGRYQSRRIMKLTFAMFLEFRPSVRDTTAVTRHGIMPRPFLRANKVLLQQEVSGYPFKKKNKDYTVNKGNPPLLIMDSICETEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9GM04</accession>
    <name>E9GM04_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RIH_assoc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_104360</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732552">
        <property type="protein sequence ID" value="EFX79476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79476"/>
    <dbReference type="EnsemblMetazoa" id="EFX79476">
        <property type="protein sequence ID" value="EFX79476"/>
        <property type="gene ID" value="DAPPUDRAFT_104360"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_104360"/>
    <dbReference type="eggNOG" id="KOG0019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_605904_0_0_1"/>
    <dbReference type="OrthoDB" id="94996at2759"/>
    <dbReference type="PhylomeDB" id="E9GM04"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="RIH_assoc" evidence="4">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX79476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="365" mass="40904" checksum="2B20038EA99D0BB3" modified="2011-04-05" version="1">MHNVALINKTLETLTEYWQGPCHENQNCIATHESNGLDITALLLTDINPLGQRRMDLVLELKNNASKLLLAVMESRGDSENAERILYNMNPRQLVDVACKAYHQKLVGGEEAASPKEVGQNIYILCHQLAQHNKKLATLMKPPPVDGVSDCLPHSGNVRVFDQRHESSRLPHGGARRPGIESGRLLQGVDDMFDEMKWQKKLRGQPFLFWVSSHMSIWSQILFNLAVIINLIVAFFYPFDTDGPSPDPGTHLSGLIWAVMLLSAAVAITLPKPSANMERIMKAQAARDTSTMGYMAAKKHLEINSDHPIVKALRVKAEADKNDKAVKDLFMLLFETSAVIWFLPGRARRPCFSHLPHDQIGFGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9GNC8</accession>
    <name>E9GNC8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_52830</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732554">
        <property type="protein sequence ID" value="EFX79051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79051"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_52830"/>
    <dbReference type="eggNOG" id="KOG3520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003962_0_0_1"/>
    <dbReference type="InParanoid" id="E9GNC8"/>
    <dbReference type="OMA" id="NIWMERI"/>
    <dbReference type="OrthoDB" id="319635at2759"/>
    <dbReference type="PhylomeDB" id="E9GNC8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="SSF48065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX79051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="353" mass="40817" checksum="BEFF30B5E0F84071" modified="2011-04-05" version="1" fragment="single">DWTRNLDPDVVDKMTPKEKQRQEVVNELFHTERSHVRNLKVLDRVFYRPLLDNGFSDLVNLLFPNLPDMLEIHGRFNTLMKARKRDQPAVETVGDILVAMFDGPNGEAFQQAAATFCKYQSVALESLRDRRKKDSKLQAFLAEAEGNPVCRRLQLKDIIPTAMQRLTKYPLLLESLAKYTQPRSEEMTLVRRCLERSREILNKVNQAIKEAENYNRLVDIQRRLDKSAFEKSDHAIANELKNFELTKHRLIYEGALTWRTKGQKNVDLHVVLLEEYILLLQKQDDKYVLKFHSINYLNSKEESKCTHSPIIKIATVLVRPVATDKLALYLVNTSPTGAQIYDLVAVSIAERKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9GNM5</accession>
    <name>E9GNM5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit p66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_53112</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732555">
        <property type="protein sequence ID" value="EFX78938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78938"/>
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</entry>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21292972"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
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    <sequence length="241" mass="27313" checksum="B681C447CE7703ED" modified="2011-04-05" version="1">MDDITDGAKSLSIAPIKKEEEGNSEENTEPIPEVNPNAPIIVSGKAYTVAGKRSDIEEIIGNYGSEIIGGFHKTIDGGRGICYIRMPKAESEQKTMLEKFNRKNILVWREKEVKQSTNGYELDLAIEEHLQFVIDNIDRIKFFRSPEIENNSEESNNSAKISYVLPKGCYCMPNGNPVGTPNKCKMGVKIDTVNTNKKNNKQIYKKDLEIIITNHLERTEENINPRLKPKQESKEIKTEKK</sequence>
</entry>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
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                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <end position="52"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="181" mass="21394" checksum="E3A8B88F188A4FFB" modified="2011-04-05" version="1">MESNILSSLKGGYPHLTEKILNLLDARSLANAELVCRQWRSFIADGRCWKKYLLSKKVTSIPNIFSWAEYSGDNESERHHNKQDWMKIHNFYQKLEDNWRSASCRQQKIVNYKAKCFSMNTTKIFTAGYVENQCIIKTWNRKSLHCERNFTDEDKLHIVSMDCDDDLLVTMSIDAWRPRFT</sequence>
</entry>
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                <person name="Basu M.K."/>
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                <person name="Choi J.H."/>
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                <person name="Dusheyko S."/>
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                <person name="Jogdeo S."/>
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                <person name="Manak J.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX78853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="58" mass="5984" checksum="7985E583A9304F00" modified="2011-04-05" version="1">MTTIVTRGSTLDDCIWTGTAPFCEGGCDMVGYVARETSSSGDGATCWTGIKVLCCPAS</sequence>
</entry>
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    <accession>E9GPD3</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="3">
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        <lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Arnold G.J."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Basu M.K."/>
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                <person name="Tsuchiya D."/>
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                <person name="Andrews J."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Schaack S."/>
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                <person name="Wolf Y.I."/>
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                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C12 family. BAP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="EMBL" id="GL732567">
        <property type="protein sequence ID" value="EFX76605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76605"/>
    <dbReference type="EnsemblMetazoa" id="EFX76605">
        <property type="protein sequence ID" value="EFX76605"/>
        <property type="gene ID" value="DAPPUDRAFT_54920"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_54920"/>
    <dbReference type="eggNOG" id="KOG2778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018316_2_0_1"/>
    <dbReference type="InParanoid" id="E9GV64"/>
    <dbReference type="OMA" id="IAINEQH"/>
    <dbReference type="OrthoDB" id="1363547at2759"/>
    <dbReference type="PhylomeDB" id="E9GV64"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="PTHR10589"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH_1" evidence="11">
        <location>
            <begin position="12"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="UCH_C" evidence="12">
        <location>
            <begin position="311"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="8">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFX76605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="377" mass="42728" checksum="AA5B4D819CB57F11" modified="2011-04-05" version="1">MPIEINDLSEGWLELESDPGIFTLLLEDLGTCGVQVEEVYDLQKPLDGDAPVYGYIFLFRWRERSRRKTILDAEQFIKDETAINNMFFAHQVVPNSCATHALLSILLNCPQVTLGPTLSRLKLDTSGMSPDNKGLAIGNTPELALAHNSHAAPAVACDRNERNANVPSSGRFSAEAFHFVSYVPVDGQLFELDGLKPFPIDHGPWAPNEDWTELFRRVIQERIGSATAGGEPYHDIRFSLMAVVPDKRMAVRQRLNLLKTNNQPVSDASSRDSDVMGLQSNEVIAAEKRNQKQRFGSRDLMALLKSLEKEIDTYEVLLAEEIEKRKKYRVDHCRRTHNYDEFICTFLSMLAERGTLASLVEQNTTRRKRSHRFPHFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9GVK2</accession>
    <name>E9GVK2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chloroplast protein-transporting ATPase</fullName>
            <ecNumber evidence="1">7.4.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_55207</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="7.4.2.4" evidence="1"/>
    <dbReference type="EMBL" id="GL732568">
        <property type="protein sequence ID" value="EFX76513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76513"/>
    <dbReference type="EnsemblMetazoa" id="EFX76513">
        <property type="protein sequence ID" value="EFX76513"/>
        <property type="gene ID" value="DAPPUDRAFT_55207"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_55207"/>
    <dbReference type="eggNOG" id="ENOG502QS7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034408_0_0_1"/>
    <dbReference type="InParanoid" id="E9GVK2"/>
    <dbReference type="OMA" id="VMERERC"/>
    <dbReference type="OrthoDB" id="716070at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015462">
        <property type="term" value="F:ABC-type protein transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="429"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFX76513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="551" mass="62443" checksum="467CA903E2708472" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9GW50</accession>
    <name>E9GW50_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_306257</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Lopez J."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
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                <person name="Wang M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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    </reference>
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</entry>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Hatcher P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">Belongs to the TOG/XMAP215 family.</text>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pritham E.J."/>
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                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX74306.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="EFX74306.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="544" mass="58911" checksum="FE2ED372F15B7D95" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
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    <name>E9H294_DAPPU</name>
    <protein>
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        </submittedName>
    </protein>
    <gene>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732585">
        <property type="protein sequence ID" value="EFX74130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74130"/>
    <dbReference type="EnsemblMetazoa" id="EFX74130">
        <property type="protein sequence ID" value="EFX74130"/>
        <property type="gene ID" value="DAPPUDRAFT_307437"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307437"/>
    <dbReference type="eggNOG" id="KOG3668">
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="270" mass="31457" checksum="0A4A2260F500C7BC" modified="2011-04-05" version="1">MLIKEFRIPMPLSVEEYQYGQLYAFSVESLNNTGGGEGIEVLRSEPFKDVLLNNKRHSGQYTYKIYHMGSKAPGFMKHLMPKGSFEFHEESWNAYPYSKTVISNPKFMKENFQLVIESMHHAGGPDVDNILDLSEEMLKLREVVHVDIANDKISSKDYKADLDPTIFRSKKTGRGPLTGSWLKSVKKNSLMTCYKLVTVEFKWFGLQGRVENHIMNTEQRIFNLFHRQIFCLLDEWCNMSMEDIRKFEDKVKEELDKQLKYGEPRGMTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9H3B3</accession>
    <name>E9H3B3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasmatic actin</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="2" type="ORF">DAPPUDRAFT_347743</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX73805"/>
    <dbReference type="EnsemblMetazoa" id="EFX73805">
        <property type="protein sequence ID" value="EFX73805"/>
        <property type="gene ID" value="DAPPUDRAFT_347743"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_347743"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="E9H3B3"/>
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    <dbReference type="PhylomeDB" id="E9H3B3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
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        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="PTHR11937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
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    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX73805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="374" mass="41977" checksum="033B7C44C9DAD91D" modified="2011-04-05" version="1">MGDDAVNALVVDSGSGMCKAGFAGEPAPRAVFPSIVGRHRYPNFMVGMSQRDSYVGNEAQSKRDILNLKYPIEHGMILNWHDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIDGVLTLYASGHTNGIVLDSGDGVSHTVPIYEGYALPHAILRLGLAGRDLTDYLRTILTERGHYFTTTAEREIVRDIKEKLCYVALDFEQEMAISASSYTLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCDIHETTYNSIMKCDVDMRKDLYAVLSGGTTMYPGFADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMLISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>E9H4M8</accession>
    <name>E9H4M8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_325411</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732592">
        <property type="protein sequence ID" value="EFX73326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX73326">
        <property type="protein sequence ID" value="EFX73326"/>
        <property type="gene ID" value="DAPPUDRAFT_325411"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_325411"/>
    <dbReference type="HOGENOM" id="CLU_1355890_0_0_1"/>
    <dbReference type="OrthoDB" id="324984at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14362">
        <property type="entry name" value="CUE_TAB2_TAB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041911">
        <property type="entry name" value="TAB2/3_CUE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX73326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="202" mass="21712" checksum="B03F3C8CD30480AA" modified="2011-04-05" version="1">MDHTELTQFALKQLFYQVKQGFPEVPDAVVNDCIRKAGYNRRAAEALLQKEAPKYGRFPLVKKMPQGPPKSLSAGNSPLDGGHKPLVDCLTPTKVPPPLPVTPPVGAAASTGPSPPIYTSPLYRPDIDLSLPPPDLTGGRGASSQVQVFCDQPRSSTSVNVILQPDTVPYVTYSSASTDHHRGLHSQLKITISPQGIDPFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E9H4N0</accession>
    <name>E9H4N0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guided entry of tail-anchored proteins factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tail-anchored protein insertion receptor WRB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Tryptophan-rich basic protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_307920</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WRB/GET1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732592">
        <property type="protein sequence ID" value="EFX73325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX73325"/>
    <dbReference type="EnsemblMetazoa" id="EFX73325">
        <property type="protein sequence ID" value="EFX73325"/>
        <property type="gene ID" value="DAPPUDRAFT_307920"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_307920"/>
    <dbReference type="eggNOG" id="KOG4253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121992_0_0_1"/>
    <dbReference type="InParanoid" id="E9H4N0"/>
    <dbReference type="OMA" id="VANHWAW"/>
    <dbReference type="OrthoDB" id="1498067at2759"/>
    <dbReference type="PhylomeDB" id="E9H4N0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX73325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="160" mass="18506" checksum="87D0109A3E859D9C" modified="2011-04-05" version="1">MFTFWMIAVFILIGSLLPSIVKWGTHFVFKVSDEEKKIREEFRGLRKELTGISAVDEFARYARIQRKMNKLDEQIQSLGQSRMDGRESVRWKLTKAIQVVNGAVLVYLAVTQRYEPVLTGLTDWFWPLNLLLSYPTGIEGALSIVFWLFICNNACRALIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9H6C0</accession>
    <name>E9H6C0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_325973</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732597">
        <property type="protein sequence ID" value="EFX72629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX72629"/>
    <dbReference type="EnsemblMetazoa" id="EFX72629">
        <property type="protein sequence ID" value="EFX72629"/>
        <property type="gene ID" value="DAPPUDRAFT_325973"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_325973"/>
    <dbReference type="eggNOG" id="KOG1330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_12_1"/>
    <dbReference type="InParanoid" id="E9H6C0"/>
    <dbReference type="OMA" id="TCFTIAL"/>
    <dbReference type="OrthoDB" id="891881at2759"/>
    <dbReference type="PhylomeDB" id="E9H6C0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="366"/>
            <end position="388"/>
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    <feature type="transmembrane region" description="Helical" evidence="4">
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        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="5">
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="516"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="523"/>
            <end position="554"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="DAPPUDRAFT_254223"/>
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    <dbReference type="eggNOG" id="KOG1943">
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="3">PBPe domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
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        <location>
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        </location>
    </feature>
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            <end position="69"/>
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        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX72504.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9H8E1</accession>
    <name>E9H8E1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732604">
        <property type="protein sequence ID" value="EFX71965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71965">
        <property type="protein sequence ID" value="EFX71965"/>
        <property type="gene ID" value="DAPPUDRAFT_326707"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326707"/>
    <dbReference type="HOGENOM" id="CLU_1322112_0_0_1"/>
    <dbReference type="OrthoDB" id="1443504at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="208" mass="22884" checksum="17D8BB2DC5A9BFD6" modified="2011-04-05" version="1">MTDSQTQSSVRKQANKFHIVNLDVDVVILNKKVKQVQSAVVPDIWVSDGICFYPNSKNSLPYVMRRSPVGKNWKTYPSTIESTFDTYTEARNKLAATNSDIDTTDSQHEASAAVNEEGRPKRKKRKPTRQMSADESAEDSESSDSDLEDGDDDVQPAVPAGLCAEKNATCYVPPKSATAPDRQVFTVPLTVNDVRSSQQPTASINQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E9HA82</accession>
    <name>E9HA82_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_111828</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732610">
        <property type="protein sequence ID" value="EFX71383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71383"/>
    <dbReference type="EnsemblMetazoa" id="EFX71383">
        <property type="protein sequence ID" value="EFX71383"/>
        <property type="gene ID" value="DAPPUDRAFT_111828"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_111828"/>
    <dbReference type="eggNOG" id="KOG0019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_1_3_1"/>
    <dbReference type="InParanoid" id="E9HA82"/>
    <dbReference type="OMA" id="TENMERI"/>
    <dbReference type="OrthoDB" id="924636at2759"/>
    <dbReference type="PhylomeDB" id="E9HA82"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX71383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="570" mass="64959" checksum="6CB10AA3488D6BF6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E9HBX7</accession>
    <name>E9HBX7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_112401</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732618">
        <property type="protein sequence ID" value="EFX70753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70753">
        <property type="protein sequence ID" value="EFX70753"/>
        <property type="gene ID" value="DAPPUDRAFT_112401"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_112401"/>
    <dbReference type="HOGENOM" id="CLU_060622_0_0_1"/>
    <dbReference type="InParanoid" id="E9HBX7"/>
    <dbReference type="OrthoDB" id="1806536at2759"/>
    <dbReference type="PhylomeDB" id="E9HBX7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="WW_dom-bd_prot_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13361">
        <property type="entry name" value="PTHR13361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="351" mass="39113" checksum="D7C4FB68857738BC" modified="2011-04-05" version="1">MAQSLIPALTSIDEEEEILSDLKSITDLDLLKRLRTSGKMVHTKAGKKLMESIAAKEDRDTVRALRAVYVRDFDLLEKRHDRYVQCKAPNYSQDDLDGEKDWIQAVIYDHLAILAKCDDYLALTNSRSASVVSRDSSRHSSVSSRQAKIHEAERKEKEAELMLQQVEDETRRREEEDAKIREAEDYKRRVESERKQREIRDEIDLQRLSGAIMRQQLNDLTVDDQAVPTRASSFVSGLSRVSRTSSRPSLPNNATLLAQTPAASIQASTMTTTAPVTRIIATPQPQPSTVVISMAAQTQPMTTPLVGSTSRIPTPTRLFGQPAATMPSTPKAVIKVMGIAPSLQSVAQSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCE6</accession>
    <name>E9HCE6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_328004</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732619">
        <property type="protein sequence ID" value="EFX70622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70622"/>
    <dbReference type="EnsemblMetazoa" id="EFX70622">
        <property type="protein sequence ID" value="EFX70622"/>
        <property type="gene ID" value="DAPPUDRAFT_328004"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_328004"/>
    <dbReference type="eggNOG" id="KOG2816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028365_1_1_1"/>
    <dbReference type="InParanoid" id="E9HCE6"/>
    <dbReference type="OMA" id="QASIWIL"/>
    <dbReference type="OrthoDB" id="763423at2759"/>
    <dbReference type="PhylomeDB" id="E9HCE6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="3">
        <location>
            <begin position="36"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX70622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="495" mass="54707" checksum="787D820E4A67EA54" modified="2011-04-05" version="1">MERSVSDASSTDLVTSTDSFTPAAPAASRLDKFKNVLAIVTVEPVLFFYMLATFMQYSVFQDLVYQKTCQSNFNSSVCQNLNNNSYALDVVQEQASHWILGSTAALTIPSIIVANYLGSYSDLYDRKWPVLFPACGMVLASIVYILMSLYDSIPVSMIVLASFLSGIFGGFVSCIMSVMSYISAVTSEESRSLRVAMLEAMTFCGGTVGPFIGGALLGATQSHAAVFLVIMAFYVLVILYVIFLVPSVKDDRSADEQLILTSENYCRKLFSCHHFQSSLQTCFKPRPNNRRRNLLLLIACALITMTVTAGEMDVAFLFTKDDPLNWSYETYSYYFGLKFGVGALSLIALSPVVRRLKLQEAITCCIGLVSKAAGLVLHGFATTNTMMFCVPFLSMFNTFCLPSIRSLLSKQVDPNELGKLFAFVASIENICTLLGSIVFNILYPLTRSIFRGFTFELAAIMLIIPLVIMSYLSYQMKRELYYVSTAAARRSDTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCM2</accession>
    <name>E9HCM2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_112602</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732620">
        <property type="protein sequence ID" value="EFX70559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70559">
        <property type="protein sequence ID" value="EFX70559"/>
        <property type="gene ID" value="DAPPUDRAFT_112602"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_112602"/>
    <dbReference type="HOGENOM" id="CLU_135818_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HCM2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="119" mass="13599" checksum="A6C9104DDFE5E2E7" modified="2011-04-05" version="1">MNIMSDETSQKGNYDDMPDLEEGPPIKHIPIPPRKVNENIYPARTEMSRLDDGAPSLKLRNFKRLIDKAKSKLPPPPGYRRNYSLITSESDSDIEKNIITDNKITPSEDEDDDDLNELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9HCT2</accession>
    <name>E9HCT2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_231613</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732621">
        <property type="protein sequence ID" value="EFX70402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70402"/>
    <dbReference type="EnsemblMetazoa" id="EFX70402">
        <property type="protein sequence ID" value="EFX70402"/>
        <property type="gene ID" value="DAPPUDRAFT_231613"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_231613"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_5_1"/>
    <dbReference type="InParanoid" id="E9HCT2"/>
    <dbReference type="OMA" id="MIKANHG"/>
    <dbReference type="OrthoDB" id="1373099at2759"/>
    <dbReference type="PhylomeDB" id="E9HCT2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="305" mass="33510" checksum="3D7EB02ECB5D5904" modified="2011-04-05" version="1">MLKLILETIYNLVMLFYYIVEALVVKFIPIRFRSKDISGQIALVTGAGGGIGRLIALGLSKLGCIVVCWDVAKQANEETARLIKMSKGQVYAYQVDLTKREEIYRAADRLKQEVGKVSILVNNAGVVTGKALLECSDELIQRTFDVNILAHFWTVKSFLPDMIMQDQGHIVTIASLAGLSGCNRLVDYCASKFAAVGFDESLRTELAVDGRKGIKTTVVCPFFVKTPLFAGIESKILPVLEPETVASETIDAILTDQPFCLVPSRLSILLGLKSMLPIKALISTYKAFGLDETMNAFEGPKTKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HEL7</accession>
    <name>E9HEL7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_328734</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732630">
        <property type="protein sequence ID" value="EFX69822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69822">
        <property type="protein sequence ID" value="EFX69822"/>
        <property type="gene ID" value="DAPPUDRAFT_328734"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_328734"/>
    <dbReference type="HOGENOM" id="CLU_126182_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9HEL7"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX69822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="149" mass="17110" checksum="FB81B37FF8B01CFA" modified="2011-04-05" version="1">MTFYFTAQEKAEIFKVTCSEKCLIHLLKYFETRYGLVDLERYRALYWEAIAKDGVVGMGPGKKIDEVFTRMESHIHDLFKHLQSDSQSVSGSQLAPSWSSILLFDVLSANDTHHKLMRIQNLAELTNLEISLVARNVEWTLAQQQTQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9HES7</accession>
    <name>E9HES7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_300687</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PIGF family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732631">
        <property type="protein sequence ID" value="EFX69722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69722"/>
    <dbReference type="EnsemblMetazoa" id="EFX69722">
        <property type="protein sequence ID" value="EFX69722"/>
        <property type="gene ID" value="DAPPUDRAFT_300687"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300687"/>
    <dbReference type="HOGENOM" id="CLU_2239241_0_0_1"/>
    <dbReference type="OrthoDB" id="1182539at2759"/>
    <dbReference type="PhylomeDB" id="E9HES7"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX69722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="105" mass="11705" checksum="1DB1E1297AE3C37C" modified="2011-04-05" version="1">MLLSALILPSVAACGKLGNFFNFSCLNLMGTNELFTCFGAWLGAFVIPLDWDCSWQVWPEPVAVGAVLGCGLSSLLKLMRPAMTINWAGYKMYWPTNFFVHERHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E9HF03</accession>
    <name>E9HF03_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_113430</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732632">
        <property type="protein sequence ID" value="EFX69685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX69685">
        <property type="protein sequence ID" value="EFX69685"/>
        <property type="gene ID" value="DAPPUDRAFT_113430"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_113430"/>
    <dbReference type="HOGENOM" id="CLU_2075481_0_0_1"/>
    <dbReference type="InParanoid" id="E9HF03"/>
    <dbReference type="OrthoDB" id="1343623at2759"/>
    <dbReference type="PhylomeDB" id="E9HF03"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX69685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="118" mass="13267" checksum="3E4DBA10F501D891" modified="2011-04-05" version="1">MGNHATHLFYPAVKFAKKNGIMLPPHCSHTLKPFDVNVYGPLKSALALSHNEWLQANSSKRIVVKEFAELTRQPYIAAFTPNIISGFKSTEIEPFNIFAISDYRFLASLVTDRDEIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9HG07</accession>
    <name>E9HG07_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_228708</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
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        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Pritham E.J."/>
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                <person name="Shiga Y."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="184" mass="21798" checksum="46107987E7F3445C" modified="2011-04-05" version="1">MSNFIDDWVEIPNHHKVPVPTKPSELLHSTYHLVKTNKWKPLTSLIILAEDYPRYGRYCTEYTQHDARFLYFVETAVDVFHKPIFARNGYGINKLQVNADQHLLAEYEKIIEENQALQLHQSRMEKYITLRVKSQKWPYSYNYLPLQPLEASRTGLSKGGGTISKLHRLRYWYITQQPRHPRGQ</sequence>
</entry>
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    <reference evidence="1 2" key="1">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
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                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_262528"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="81" mass="9100" checksum="025E62AA33390886" modified="2011-04-05" version="1">MCHSFSIQCRVGNGVEWKLKDEKKSKEEEEVEEEQYRGEHLIRFQPPAMPAPTMTELACATLCFRSGASAFGRSSTPLYGS</sequence>
</entry>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
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                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732717">
        <property type="protein sequence ID" value="EFX66065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX66065">
        <property type="protein sequence ID" value="EFX66065"/>
        <property type="gene ID" value="DAPPUDRAFT_116738"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_116738"/>
    <dbReference type="HOGENOM" id="CLU_1130074_0_0_1"/>
    <dbReference type="InParanoid" id="E9HQC4"/>
    <dbReference type="OrthoDB" id="450389at33208"/>
    <dbReference type="PhylomeDB" id="E9HQC4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX66065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="246" mass="28098" checksum="67DDA8D0A8600F5E" modified="2011-04-05" version="1">MVNLLDNTGNTPAHYVSDIPTLKILIANKARLDVVNKFELTPMMTAAKEQRNSIYQYLRLYNNKTQVKQNPVVTVSKPTIHDRFGKYYRERIREINEMLVAKANFRPDYEDLPELSCEMPPLEELDVPKFDFCGIPFKGWEAPVEAAATQQNTTDLETTASASSSKDGMSRHDETTPVLKVRHLKRLQGEKRISLPLPLGCRYITTEPMELSGSEESDLEREILFDKDRTFAKYTGDDLSEFGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>E9HQQ3</accession>
    <name>E9HQQ3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_116846</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Diplostraca</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
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            <begin position="1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
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    </evidence>
    <sequence length="175" mass="19274" checksum="1441C45C0875FE44" modified="2011-04-05" version="1">MKIAVCCVIVLAALAAPSLAARTVSQEGYDLIKGFEGLSLVAYQDVGGIWTIGYGNTRYQDGSAVRQGDTITQQGADDLFQYWVDQSVKVDRLVGTGVVIRQVQFDALVSITYNIGTGAFSTSTLLSKVRVFPDNPTIRDEFLRWVDVNGQVVQGLVNRRTKEADYYFSKVENMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Tsuchiya D."/>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Krijgsveld J."/>
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        <source>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="241" mass="26092" checksum="0AB8459C71256C05" modified="2011-04-05" version="1">MDIEKSVTEPSKYKMDIKEEAVGLGSVDIVDNNLKEHIKTDSSVTEPKYKMDIKEEAVGLGSVDIVDNTLKEHIKTDSSVTEPKYKMDIKEEAVGLGSVDIVDNTLKEHIKTDSSVTEAKYKMDIKEEAVGLGSVDIVDNTLKENNNIDSSSATEPKYKLDIKEEAVGLGSVDVVDNTLKENNNIDSSPATGPKYKLDIKEEAVGLGIVDVDDNTLKETTSTALTVVDPSSPAVQSGSTKK</sequence>
</entry>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX62711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="212" mass="23582" checksum="480845A565FFF8AC" modified="2011-04-05" version="1" fragment="single">MVQQLKASRSGTKGHMTRSIGLINGYANKVMNQQEANSLEVLEGKLKGLYETYVIASRDILEKLRASKATQEELDEEQTITLQTQDEVLGARAIIKQKKQEWLDDERDRRLLTLFQATNQASNLAGNQATSQAQMAQLIAQIVAAIPAPPAPVINVTAAPAPAPAVQSIRLPQRQIKHFRGDVLEWTQFWESFNAAVHSSSLSNVQKFDYLK</sequence>
</entry>
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    <name>E9I054_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
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    </gene>
    <organism evidence="4">
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        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX62626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="EFX62626">
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        <property type="gene ID" value="DAPPUDRAFT_229977"/>
    </dbReference>
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    <dbReference type="PhylomeDB" id="E9I054"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0030686">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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    </dbReference>
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        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="AARP2CN"/>
    </dbReference>
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        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="PTHR12858"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX62626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="274" mass="31464" checksum="348ED299EF31238E" modified="2011-04-05" version="1">MEDHVDEDKKKAHRERRAGRKADKKNSRIHTSKKWMRKAFAIQSLAKARKHFHSTDFLKKCTREKNCCTSGQLHGTYPKNEIKNLGRFISVMKFLPLLWRSTHPYVLVDRLEDMTPPSRLHENPKCNRDICLYGFARGVHLRNHCPIHIPGCGDFRLKDVSFLPDPCPLPDKLKKRSLVEKEKLIYAPMSGVGGVIYDKDSIYIELGGSHSHSKQDGPTNPKSEMISSLMKLQRTLDAQMCESRGEGPTLTQAHDEDEELLDDDGDVSYKREIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9I146</accession>
    <name>E9I146_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tubulin-specific chaperone D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_120367</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCD family.</text>
    </comment>
    <dbReference type="EMBL" id="GL733707">
        <property type="protein sequence ID" value="EFX62283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX62283"/>
    <dbReference type="EnsemblMetazoa" id="EFX62283">
        <property type="protein sequence ID" value="EFX62283"/>
        <property type="gene ID" value="DAPPUDRAFT_120367"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_120367"/>
    <dbReference type="eggNOG" id="KOG1943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003043_4_1_1"/>
    <dbReference type="InParanoid" id="E9I146"/>
    <dbReference type="OrthoDB" id="79003at2759"/>
    <dbReference type="PhylomeDB" id="E9I146"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034333">
        <property type="term" value="P:adherens junction assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="Tubulin_specific_chaperoneD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="PTHR12658"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFCD_C" evidence="3">
        <location>
            <begin position="318"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX62283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="407" mass="46124" checksum="73858B9A88317E96" modified="2011-04-05" version="1" fragment="single">YSAAKGIGRLTSRLSKNFADQVIESIMELFSLWESDMTWHGGCLALAELAVFIFIRHGLLLPQRLSSVLPFMEQAMLYDELRGNFSVGLAVRDAACYLCWALARSYDPSLLQPFVHQLAKALVITTVFDRTRRSTGHFSSRHRHSDHLRLVRLRKNAYLQLSLFVAQYEEYRPHLIQHLVDRKVIHWDTVIRQLTSQALHQMTFLDPESMKLILSTQILPRCTNSELYLRHGSILASGKVISALCQVAKDHQRGVDQVTLAVIFRTLIDGLEDYTVDSRGDIGAIVRESTMSSIQVLTNTSQPELLEADLIRSVLHAVAKQSTEQIRRTRDPTIPHIEQLEELRSIIPPPPLDISTEKECFDLWMKVMRLDTYRKAVITGLVSSIGSLTESLVKSSSTSSKLTIARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9I1N8</accession>
    <name>E9I1N8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_337458</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733835">
        <property type="protein sequence ID" value="EFX62092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX62092"/>
    <dbReference type="EnsemblMetazoa" id="EFX62092">
        <property type="protein sequence ID" value="EFX62092"/>
        <property type="gene ID" value="DAPPUDRAFT_337458"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_337458"/>
    <dbReference type="eggNOG" id="KOG1245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_555831_0_0_1"/>
    <dbReference type="InParanoid" id="E9I1N8"/>
    <dbReference type="PhylomeDB" id="E9I1N8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDT" evidence="3">
        <location>
            <begin position="209"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX62092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="491" mass="54853" checksum="37748ADA5A0840B7" modified="2011-04-05" version="1">MKMEDVCDLPFNPDEIFTVETLDDTEILIELGLLGQENPDEVLNGDVLLELESFLFDGNSAESTKGDLYQDPPIGQTVPASGLEEMEFEESNLGLNLDLDLQYVPTFSESVDGDEDVFSKYDYRDLVNIQQLDFELFEAQRQKGPTFDDVLVEDAFAQARKLVIQLGFCDEALAIDRENQSQSSIEDLSLMDHKPLPNIPRITNLKLAGQALADILMVYEFLHTFGETLGFDMESLPSLDCLQRALLYDSEAEEELLLVTTHLLVYCVEDPGIAHPNSYTTLLGQMLKQTDITTTNVSEILRIYLEANGLGDLEMPAADKITSSPLKLAAGEYPDTEAFLMSEWLRRKHFLSLNPTQKAAILGFLVNELLQNKAVIGQIEGAIEGQSTARRDRLVVNMKIKKLKTLHSKKHRTSLVSSSFNFSSTAANLADLMDDSTTHDESNHSASGSEEEDEITETEEHPEEADEDSWGEADDNADQGDEDEDEIFLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E9I2X8</accession>
    <name>E9I2X8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_338568</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX61652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61652">
        <property type="protein sequence ID" value="EFX61652"/>
        <property type="gene ID" value="DAPPUDRAFT_338568"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_338568"/>
    <dbReference type="HOGENOM" id="CLU_1268039_0_0_1"/>
    <dbReference type="InParanoid" id="E9I2X8"/>
    <dbReference type="OMA" id="DVEIMIS"/>
    <dbReference type="OrthoDB" id="1114912at2759"/>
    <dbReference type="PhylomeDB" id="E9I2X8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="259" mass="29513" checksum="731484A27CC4FD5A" modified="2011-04-05" version="1">MSGKRKKDYCAVSLSILNLLKLDGNLPEVQEFMLDFEKAAWQACRTIFPAVKPVGCSFHLTQSFYRNIKKIGLAPQYRKDKETRKICRQILSLHLLPAEKIVKQFQNIKDGASGLMLKFCCYVEENYIKSTVWTPSNWSMHGQHIRTNNHVEGTHNKLKAVVGPASTNIVKFLILMKEEADKIAMTAKLLSQKQVLKKLNKNAATMQYQLSTLWDAHNRAIDPISSKKLLEELGMLTKIHSKAQLLELKELQAQDVESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9I3I5</accession>
    <name>E9I3I5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glucosylceramidase</fullName>
            <ecNumber evidence="2 5">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_339516</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="2 5"/>
    <dbReference type="EMBL" id="GL734569">
        <property type="protein sequence ID" value="EFX61445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX61445"/>
    <dbReference type="EnsemblMetazoa" id="EFX61445">
        <property type="protein sequence ID" value="EFX61445"/>
        <property type="gene ID" value="DAPPUDRAFT_339516"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_339516"/>
    <dbReference type="eggNOG" id="KOG2566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103910_0_0_1"/>
    <dbReference type="InParanoid" id="E9I3I5"/>
    <dbReference type="OMA" id="WNIALDI"/>
    <dbReference type="OrthoDB" id="644299at2759"/>
    <dbReference type="PhylomeDB" id="E9I3I5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="PTHR11069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="domain" description="Glyco_hydro_30" evidence="6">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_30C" evidence="7">
        <location>
            <begin position="135"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX61445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="187" mass="20939" checksum="F3C5732DE32C8AC6" modified="2011-04-05" version="1" fragment="single">VLANADANTYVSGIGVHWYQNFIAPPSVLTTTHEKFPDRFILATEACEGTFPKETVVLGAWERLESYAKDIIENLNNWAVGWVDWNLALDEGGGPNWSENFVDSPIIVNNTNDEFYKQPMFYAMGHFSKYIPENSVRVNIEISNDTTIIGSAFVLPDGNRAVVILNQSDEEKTIVLNDAELGSLEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9I436</accession>
    <name>E9I436_DAPPU</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL734887">
        <property type="protein sequence ID" value="EFX61244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61244">
        <property type="protein sequence ID" value="EFX61244"/>
        <property type="gene ID" value="DAPPUDRAFT_122392"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_122392"/>
    <dbReference type="HOGENOM" id="CLU_2029022_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX61244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="122" mass="13954" checksum="8A313D275744F493" modified="2011-04-05" version="1">MAGVKRFARNHRKQYRANPKQVYKCNSSIYGNLSAGAEFEKLMHHAHIQVAGMTQTQPEPSMFVKIKVDDNDVVVGYLIVIAFVDDVRMFGTEPELQEYKAKIASCMKVFKPIKISRREFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9I5E2</accession>
    <name>E9I5E2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_341441</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL735584">
        <property type="protein sequence ID" value="EFX60788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60788">
        <property type="protein sequence ID" value="EFX60788"/>
        <property type="gene ID" value="DAPPUDRAFT_341441"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_341441"/>
    <dbReference type="HOGENOM" id="CLU_2560614_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX60788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="82" mass="8589" checksum="38C60269A1C0438E" modified="2011-04-05" version="1">MAVASVRRHQDVQTERHSVVALTVDLPGVLASALADLAPRLVEAEGGAQGLVTSYLETSIETASQMLEEASCKPGKNNATRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9I722</accession>
    <name>E9I722_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_344715</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL736874">
        <property type="protein sequence ID" value="EFX60208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX60208">
        <property type="protein sequence ID" value="EFX60208"/>
        <property type="gene ID" value="DAPPUDRAFT_344715"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_344715"/>
    <dbReference type="eggNOG" id="ENOG502SG4M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1021455_0_0_1"/>
    <dbReference type="InParanoid" id="E9I722"/>
    <dbReference type="OrthoDB" id="188037at6656"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="37"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX60208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="273" mass="30203" checksum="0383F44649A89B24" modified="2011-04-05" version="1" fragment="single">MFGQPEAELEGQPLLQGQDAAATLTTEVAALAAGEPLQRELWLTRADGQRIWVQIDAHAADTQAQLDGADGAWWMMQDRTEIRHAQQELQRRFEELHATNRQLEEAQNQLLQQDKMASIGQLAAGVAHEINNPVGFVSSNLNSLRQYAGELMALASAFEAGASRPQDAQAAAALAELRARVDLEYLSEDVPQLLDECADGLGRVKKIVQDLKDFSRVDQADWQDADLNAGLESTLNVVRHEVKYKAEITRQLQPLPPVRCMAGQLNQVFMNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9FR08</accession>
    <name>E9FR08_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="ORF">DAPPUDRAFT_300124</name>
    </gene>
    <organism evidence="34">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O</text>
            <dbReference type="Rhea" id="RHEA:38379"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52323"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:38380"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38219"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:38220"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38435"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:38436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:37915"/>
            <dbReference type="ChEBI" id="CHEBI:52323"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:37916"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:55340"/>
            <dbReference type="ChEBI" id="CHEBI:34116"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:138734"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:55341"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:55344"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:138734"/>
            <dbReference type="ChEBI" id="CHEBI:138735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:55345"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38307"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
            <dbReference type="ChEBI" id="CHEBI:75729"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:38308"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38439"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38440"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:37911"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:37912"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38163"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:75583"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38164"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:55296"/>
            <dbReference type="ChEBI" id="CHEBI:45479"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:138722"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:55297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:38071"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:38072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:10869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:11488"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:63410"/>
            <dbReference type="EC" id="2.3.1.76"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:11489"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:38175"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:38176"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl hexadecanoate</text>
            <dbReference type="Rhea" id="RHEA:38167"/>
            <dbReference type="ChEBI" id="CHEBI:16125"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:75584"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38168"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA</text>
            <dbReference type="Rhea" id="RHEA:38211"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:75586"/>
            <dbReference type="ChEBI" id="CHEBI:75608"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:38212"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:38171"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:75586"/>
            <dbReference type="ChEBI" id="CHEBI:75587"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:38172"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="21">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="29">Homodimer or homotetramer; both forms have similar enzymatic activities.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20 30">Endoplasmic reticulum membrane</location>
            <topology evidence="20 30">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22 30">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90273"/>
    <dbReference type="EnsemblMetazoa" id="EFX90273">
        <property type="protein sequence ID" value="EFX90273"/>
        <property type="gene ID" value="DAPPUDRAFT_300124"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300124"/>
    <dbReference type="eggNOG" id="KOG0380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018190_0_0_1"/>
    <dbReference type="InParanoid" id="E9FR08"/>
    <dbReference type="OMA" id="HAIIVWL"/>
    <dbReference type="OrthoDB" id="1275897at2759"/>
    <dbReference type="PhylomeDB" id="E9FR08"/>
    <dbReference type="UniPathway" id="UPA00230"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050252">
        <property type="term" value="F:retinol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027251">
        <property type="entry name" value="Diacylglycerol_acylTrfase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="PTHR10408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="PTHR10408:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500231">
        <property type="entry name" value="Oat_dag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="28 30" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="25 30" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="27 30 32" id="KW-0472">Membrane</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23 30" id="KW-0808">Transferase</keyword>
    <keyword evidence="24 32" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="26 32" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" evidence="31">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00000389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00000645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00000883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00000895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00001009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00001100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00001118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00001150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00001313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00001349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00001764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00001793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00001796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00005175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00023610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="EFX90273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="512" mass="60062" checksum="E66CD12957712BFB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRC0</accession>
    <name>E9FRC0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_299950</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX90224">
        <property type="protein sequence ID" value="EFX90224"/>
        <property type="gene ID" value="DAPPUDRAFT_299950"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299950"/>
    <dbReference type="eggNOG" id="ENOG502QT4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061034_0_0_1"/>
    <dbReference type="InParanoid" id="E9FRC0"/>
    <dbReference type="OMA" id="VETHCSN"/>
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    <dbReference type="PhylomeDB" id="E9FRC0"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX90224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="281" mass="31781" checksum="536E1E7D0D95B517" modified="2011-04-05" version="1">MPCSAYTLSLATIAAVISVALIAIAFSTDNWSRITIDRLKLEPQVTRGDLALQGELESNILYFSRTKGLFRICFDDKKVPKGVETYRSPVETICTNIDYYIPDNKGDTKSFSEDAMARLHMGRAMIALFIVSFFFDFVAFWTGVVGCWRRGAGNITSTAILMLLACLFSAGGMGLWHGVEFYENEKLVGEREFLRPKVLKDASKIDYDWSYMIAWIGVGFALISSILFSCAAICLRREREKEEAVNMQYLMPVYPQKQQYAYGYAYPGPYAYGSQYGPYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRQ6</accession>
    <name>E9FRQ6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="4 11">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DAPPUDRAFT_299795</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="4 11"/>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90443"/>
    <dbReference type="EnsemblMetazoa" id="EFX90443">
        <property type="protein sequence ID" value="EFX90443"/>
        <property type="gene ID" value="DAPPUDRAFT_299795"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299795"/>
    <dbReference type="eggNOG" id="KOG1367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_0_1"/>
    <dbReference type="InParanoid" id="E9FRQ6"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="838642at2759"/>
    <dbReference type="PhylomeDB" id="E9FRQ6"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="371"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFX90443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="415" mass="44153" checksum="2BE2E1AFFECB604F" modified="2011-04-05" version="1">MSLKKVSIDSVPLSGQRVLIRVDFNVPMKNGAITNTQRIVAALDTVKYALEQGAKSVVLMSHLGRPDGHKEDKYSMRPIAPVLKELLNREITFLEDCVGADVEAACADPAQGSVILLENLRFHVEEEGKGVDAAGNKIKAAKEDVQKFQESLRRLGDVYINDAFGTAHRAHASMLGTGFDVRASGFLLKKELAYFAKALDNPERPFLAILGGAKVADKIQLIGNLLDQVNEMIIGGGMAYTFLKVINGMQIGNSLFDEEGSKIVKDLVAKAEKNGVKLHLPVDFTCADKFAEDAATQSASVESGIPEGWMGLDCGPNTIAHFVDPIQRAKTIVWNGPVGVFEFEKFATGTKAVMDAVVLATQNGATTIIGGGDTATCAAKWGTEDKVSHVSTGGGASLELLEGKVLPGVAALSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRR5</accession>
    <name>E9FRR5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Radical S-adenosyl methionine domain-containing protein 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putative heme chaperone</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_299799</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX89896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89896"/>
    <dbReference type="EnsemblMetazoa" id="EFX89896">
        <property type="protein sequence ID" value="EFX89896"/>
        <property type="gene ID" value="DAPPUDRAFT_299799"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299799"/>
    <dbReference type="eggNOG" id="ENOG502QRH0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_0_0_1"/>
    <dbReference type="InParanoid" id="E9FRR5"/>
    <dbReference type="OMA" id="HIPWCVR"/>
    <dbReference type="OrthoDB" id="1201842at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="4">
        <location>
            <begin position="17"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX89896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="429" mass="48342" checksum="6EF66DFC4CB4E63F" modified="2011-04-05" version="1">MRFSSKFFSPCSTDILENLKTEATMYFHWPFCKNICTFCSFNKYKKVENSFSKIIDERMEKCLIKETETILGFTGIKKINSIYFGGGTPSLAPTTTISRIINCVKQLTNVDEQAEITIECNPSSLSMTKTLEEYFKFGINRVSVGVQSLDDGTLKVLGRDHSANDSVMLLKSALDVFGSDAVSVDLLFRKPGDTIQSWKNELNEILSYKPHHISLYELTPERGTPLFRQLQSGTVVLPNEDDAASMYILALELLKEYGFERYEISNFARAGSCAQSSHNMSYWNGTQYVGIGPGAHSRFFPLGANSRESRVQALDPKSWQDLVERNGHATRLCRQQSQIDVLSELVATSLRTTKGIQPKRWLIFQPEYSLVDVFEQAPSIQMLFLSGNLQWSVDGSLQATEKGLNVVDSILPNILTVLNEFYETNKLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRZ1</accession>
    <name>E9FRZ1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EOG090X0C57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EOG090X0C57</name>
        <name evidence="4" type="ORF">DAPPUDRAFT_299824</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CH-H</strain>
            <strain evidence="6">PA42</strain>
            <strain evidence="7">TCO</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR014250">
        <property type="protein sequence ID" value="SVE83869.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR014857">
        <property type="protein sequence ID" value="SVE84476.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015475">
        <property type="protein sequence ID" value="SVE85094.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90401"/>
    <dbReference type="EnsemblMetazoa" id="EFX90401">
        <property type="protein sequence ID" value="EFX90401"/>
        <property type="gene ID" value="DAPPUDRAFT_299824"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_299824"/>
    <dbReference type="eggNOG" id="KOG3285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072097_0_0_1"/>
    <dbReference type="OMA" id="MLDGNCT"/>
    <dbReference type="OrthoDB" id="1197019at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027097">
        <property type="entry name" value="Mad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="PTHR11842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="PTHR11842:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="SSF56019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="3">
        <location>
            <begin position="16"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX90401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="SVE83869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="SVE84476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="SVE85094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="204" mass="23237" checksum="0D6FB8AA4120B487" modified="2011-04-05" version="1">MATGSAQETQNFVTLKGSVELIVDFFNYSLNSILYQRGVYPEESFIPTQHYGLTMYMSKNPEIKKYTDEILPHLKQWLTEGKIKKLVLGLCDVNSKEPLECWEFRIIPEETPTGEIKQQGTKPLKDIQQEIRNVLRQITACVTFLPLLDCVCSFDLQIHTTKDAGGEGWGDVQPITIQNAQEVQLRSFSTSIQNVHTFVSYKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E9FU70</accession>
    <name>E9FU70_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_303259</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX89521">
        <property type="protein sequence ID" value="EFX89521"/>
        <property type="gene ID" value="DAPPUDRAFT_303259"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303259"/>
    <dbReference type="HOGENOM" id="CLU_1983790_0_0_1"/>
    <dbReference type="InParanoid" id="E9FU70"/>
    <dbReference type="OMA" id="VGYTIIC"/>
    <dbReference type="OrthoDB" id="1874614at2759"/>
    <dbReference type="PhylomeDB" id="E9FU70"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019991">
        <property type="term" value="P:septate junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038976">
        <property type="entry name" value="Ssk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36692">
        <property type="entry name" value="PTHR36692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="126" mass="14163" checksum="7D536290E24D8958" modified="2011-04-05" version="1">MLLAIICIALLRYYNLSFGGELNQASYHDRYLFGVMTIGGMLLVTIPIFVAHLFGSEIRPGLDLIYSLMGFVLFLTAGILSLEFYVIYRNRPGNLNAGRSLGSMLIINSFFFLLNTIVSLVRIFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E9FX48</accession>
    <name>E9FX48_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbonic anhydrase</fullName>
            <ecNumber evidence="4">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CAA6C</name>
        <name evidence="7" type="ORF">DAPPUDRAFT_442472</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88009">
        <property type="protein sequence ID" value="EFX88009"/>
        <property type="gene ID" value="DAPPUDRAFT_442472"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_442472"/>
    <dbReference type="eggNOG" id="KOG0382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039326_2_0_1"/>
    <dbReference type="InParanoid" id="E9FX48"/>
    <dbReference type="OrthoDB" id="1377476at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="PTHR18952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="SSF51069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX88009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="322" mass="36177" checksum="C9B3608FCDD3413D" modified="2011-04-05" version="1">MPWLNSFKSLTYYIIIIFIVFQYLTVSQSSATAGWSYNNPSAWADLSGSSCGGNHQSPINIQPSQSVRKSFPKFAFQNYGNIDKVDLINNGHTAVYSLPVNFPADRVPSITGGGLNDTYKFVQFHLHWGSDSSKGSEHLIRSRSHPAELHMVHYNTKYGTYADATTHSDGLAVLGVFLKVADNDAFRPLVEQLSEVPADGDETTLKNLVSLKDLLPAQTTSFYRYSGSLTTPKCNQIVTWTVFDNPLVISEQQLKKFRSLKNDVEEPLVNNFRPVQPLNDRTVLYRSITGCEIPRSWPISWTPLLDAIKWSQCIIGFTLFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXG8</accession>
    <name>E9FXG8_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_96290</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX88271"/>
    <dbReference type="EnsemblMetazoa" id="EFX88271">
        <property type="protein sequence ID" value="EFX88271"/>
        <property type="gene ID" value="DAPPUDRAFT_96290"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_96290"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_476725_0_0_1"/>
    <dbReference type="InParanoid" id="E9FXG8"/>
    <dbReference type="OrthoDB" id="1008734at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX88271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="572" mass="62442" checksum="C1774D24065F46EA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9FXM9</accession>
    <name>E9FXM9_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbonic anhydrase</fullName>
            <ecNumber evidence="4">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CAA7M</name>
        <name evidence="6" type="ORF">DAPPUDRAFT_442491</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="GL732526">
        <property type="protein sequence ID" value="EFX88119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX88119">
        <property type="protein sequence ID" value="EFX88119"/>
        <property type="gene ID" value="DAPPUDRAFT_442491"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_442491"/>
    <dbReference type="eggNOG" id="KOG0382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039326_2_0_1"/>
    <dbReference type="InParanoid" id="E9FXM9"/>
    <dbReference type="OrthoDB" id="1377476at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87408">
        <property type="protein sequence ID" value="EFX87408"/>
        <property type="gene ID" value="DAPPUDRAFT_207683"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_207683"/>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012184_1_2_1"/>
    <dbReference type="InParanoid" id="E9G0G5"/>
    <dbReference type="OMA" id="NAIPSHT"/>
    <dbReference type="OrthoDB" id="1275401at2759"/>
    <dbReference type="PhylomeDB" id="E9G0G5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
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        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018707880" description="Pept_C1 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="3">
        <location>
            <begin position="124"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX87408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="339" mass="37817" checksum="DAD8F24EB1706B7C" modified="2011-04-05" version="1">MLLKMDFLFAFTVCAIVMTVVQGQTTEDDWRMYKKTFKKNYFIAADNGRLDRIHKRLFVTRNEQIKLHNSNPLVNYRRELTGFTDLLKEEFQKFLGVNKNAIPSHTKEAVSLRPDGSDITDPDVPSRLDYRYHTCLPGIKNQGQCAASWAFSAITSVEFNRCRNNKNISVTLSEQQLIDCDRGGLNKGCHGGFSMTAIESTMLTGIATGLQYPYKKTGGPCKYVANMKAASVKLCNYIEGGSIVDMKYALTKLGPLSATMTVTDSFADYGSGVYDSNDCDGQDPNHAVVLVGWGNQNGIDYWIGRNSWGTGWGKEGYFLIQRGVNKCGIESYPVFVKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9G0V9</accession>
    <name>E9G0V9_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_235798</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732528">
        <property type="protein sequence ID" value="EFX87337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX87337">
        <property type="protein sequence ID" value="EFX87337"/>
        <property type="gene ID" value="DAPPUDRAFT_235798"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_235798"/>
    <dbReference type="HOGENOM" id="CLU_2657000_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX87337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="76" mass="8431" checksum="FBC8AA1EA0F02AD5" modified="2011-04-05" version="1">MVQFKLSSKTKEILFARTPICSIGIFGSSSTITSYTNIYASPIYVPVPVSPPSQINQPEPVERLDSKERVSQLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E9G2L2</accession>
    <name>E9G2L2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_44917</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX86278"/>
        <property type="gene ID" value="DAPPUDRAFT_44917"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_44917"/>
    <dbReference type="eggNOG" id="KOG0717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009539_3_0_1"/>
    <dbReference type="InParanoid" id="E9G2L2"/>
    <dbReference type="OMA" id="ACKKQFK"/>
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    <dbReference type="PhylomeDB" id="E9G2L2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFX86278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="377" mass="44312" checksum="09002FF676ABC986" modified="2011-04-05" version="1">MKCHYEVLGVPLNASDDDLKKSYRKLALKWHPDKNLDNSDEAKREFQFIQAAYEVLSDPQERAWYDKHRDAILLGAKGAEYQENAVNLFEYFTSACYSGYGDDKQSFYSVYSELFSKIAAEDMEFSQDQDSDFEIPDFGYSTSDYSEVVRTFYAYWSAYCTLRPYSWLDKYNIDTLKEAPRRIQRLMEKDNKKLRDAGRKQRNEEVRALVNFVRKRDPRVKAYIKLLEEKTAQNALKTKLQQERHREKRRQLLEETTSPTKFGFTEMSDLEKQLREENDDVVQENKEGSEDEGKEGILDESNEDIPKEENSSENATNNVTDDDSDLDDDPLDLYCPACKKNFKTVKSRESHDRSKKHQIKVRALRKTMLEEEEEYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E9G3A0</accession>
    <name>E9G3A0_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1 5">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_237194</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="1 5"/>
    <dbReference type="EMBL" id="GL732531">
        <property type="protein sequence ID" value="EFX85737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85737"/>
    <dbReference type="EnsemblMetazoa" id="EFX85737">
        <property type="protein sequence ID" value="EFX85737"/>
        <property type="gene ID" value="DAPPUDRAFT_237194"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_237194"/>
    <dbReference type="eggNOG" id="KOG3847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022501_0_0_1"/>
    <dbReference type="InParanoid" id="E9G3A0"/>
    <dbReference type="OMA" id="FINSEAF"/>
    <dbReference type="OrthoDB" id="1189747at2759"/>
    <dbReference type="PhylomeDB" id="E9G3A0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eucaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX85737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="353" mass="39805" checksum="420A79024000C924" modified="2011-04-05" version="1">MELPHCYQGKTHVPAPSGKYVVGCTDIITGPDSQNGCLFRIFYPTKLNDIYARNAYIPAVEDAEPSGEQLFPVIVFSHGLKACRTSYSSFCSDISSHGFIVAAIEHRDGSACVSYTLEKGANSQESPEVKWIPYNPVPFETDEMPFRHEQLQIRTRECSRTLELLSKLNEGSEIEHILQPTMDLAKFKGVMDLSSPTIAGHSFGSTTVLRTLNADKRFKIGLAMDAWMWPLRDEPELAKSVEQPLLFINSEAFQTAANLETMKRFTVDADHTERRVVTLKGSVHYSQNDVPSLLPWYIRRFAYNSIIDPLLALQLNHRMTLLYLRKHLGHPAEEEEFSELMGQHADVICEGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9G4T4</accession>
    <name>E9G4T4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DAPPUDRAFT_208990</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732532">
        <property type="protein sequence ID" value="EFX85501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX85501"/>
    <dbReference type="EnsemblMetazoa" id="EFX85501">
        <property type="protein sequence ID" value="EFX85501"/>
        <property type="gene ID" value="DAPPUDRAFT_208990"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_208990"/>
    <dbReference type="eggNOG" id="KOG3761">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_10_0_1"/>
    <dbReference type="InParanoid" id="E9G4T4"/>
    <dbReference type="OMA" id="FGMVLRI"/>
    <dbReference type="OrthoDB" id="799628at2759"/>
    <dbReference type="PhylomeDB" id="E9G4T4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015871">
        <property type="term" value="P:choline transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
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        </source>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Basu M.K."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Thomas W.K."/>
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                <person name="Zdobnov E.M."/>
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                <person name="Tsuchiya D."/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="148" mass="16895" checksum="4DA7FD4AC72D0825" modified="2011-04-05" version="1">MGNARGWSANFRLHHPSVSNQIQLTFIFPSEFEFVFKPASKPQRLSTLCGMPNGLQGHNVETSQGFQYTGHELESESSTAALIYLDCNIFVTSGYLLRFSSRIEKLFSFTILQMRLYSFHMLKQLETPAAKLPSPEILDKGRESFIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9GET6</accession>
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            <fullName evidence="9">Uncharacterized protein</fullName>
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        <name type="scientific">Daphnia pulex</name>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
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        </lineage>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <name>FAD</name>
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    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
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        <property type="protein sequence ID" value="EFX81893"/>
        <property type="gene ID" value="DAPPUDRAFT_302851"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="project" value="GO_Central"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <sequence length="644" mass="71740" checksum="CA6A5F222DD3DBFD" modified="2011-04-05" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="354" mass="40773" checksum="7DF8B171383F8244" modified="2011-04-05" version="1">MQGTYQHIQHDCLKPNGDLDDNTTFESWLKKANRVGVEAGWTKDQKLKFFQSKLRRAAAAFNNSLGVNIKANLAAWTAAMEAGFDDATVQDMRRAQLSKIEQKFNERIREYRHRIDELYKSAYGRAAAESQDAEVIQLRNAVKKEALLKGMRLTIRTNLWNSLKATDTYEEVVEKAQVCEQVVDLRRLTEESEAHKKAEQQENEKNKNPELQQIMQAIANIQLSADSAGVAAGTVAHISEQKQEGEKQVRFSGRSRSYSPRYRERQNPEDVDERTRHYPLGQRSQSDYDWRQNRQQRAQETQPQRSNPLNRAPDNWDNQRNGGFPRGLEDRTCFFCKNKGHELVANTKDGAKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9GH13</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="common">Water flea</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
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                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
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                <person name="Wang M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
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        <property type="protein sequence ID" value="EFX80829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX80829">
        <property type="protein sequence ID" value="EFX80829"/>
        <property type="gene ID" value="DAPPUDRAFT_103010"/>
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    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_103010"/>
    <dbReference type="eggNOG" id="KOG1974">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="1230401at2759"/>
    <dbReference type="PhylomeDB" id="E9GI54"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009649">
        <property type="term" value="P:entrainment of circadian clock"/>
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    <keyword evidence="3" id="KW-0090">Biological rhythms</keyword>
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            <end position="250"/>
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        <location>
            <begin position="610"/>
            <end position="709"/>
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    </feature>
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        <location>
            <begin position="241"/>
            <end position="261"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFX80829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="831" mass="94723" checksum="A30B2FA3261B2E7D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E9GI91</accession>
    <name>E9GI91_DAPPU</name>
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        <recommendedName>
            <fullName evidence="7">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Daphnia pulex</name>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="4">Belongs to the WD repeat EBI family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX80637">
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        <property type="gene ID" value="DAPPUDRAFT_224492"/>
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    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_224492"/>
    <dbReference type="eggNOG" id="KOG0273">
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    <dbReference type="PhylomeDB" id="E9GI91"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016575">
        <property type="term" value="P:histone deacetylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ebi-like"/>
    </dbReference>
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        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
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        <property type="entry name" value="PTHR22846"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="LisH" evidence="7">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
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        </location>
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        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="487" mass="53395" checksum="429F9A97D7A1F502" modified="2011-04-05" version="1">MSFSSDEVNFLVYRYLQESGFQHSAYTFGIESHISQSNINGALVPPAALLSIIQKGLQYTEAEISVGDDGSERPMESLSLIDAVMPDVVASRQQQMQNNQKPQVVKTEPPNSNGDEPMHSYRREEETGVEIPASKSTVLRGHESEVFICAWNPTTDLLASGSGDSTARIWNMNDNSSSPTQLVLRHCIQKGGTEVPSNKDVTSLDWNCDGTLLATGSYDGYARIWTTDGRLASTLGQHKGPIFALKWNKKGNYILSAGVDKTTIIWDASTGQCTQQFAFHSAPALDVDWQSNVSFASCSTDQCIHVCKLGSDKPTKSFQGHTNEVNAIKWDPQGNLLASCSDDMTLKIWSMKQDTCVHDLQAHNKEIYTIKWSPTGPGTNNPNMNLILASASFDSTVRLWDVERGLCIHTLTKHTEPVYSVAFSPDGKYLASGSFDKCVHIWSTQSGQLLHSYKGTGGIFEVCWNSRGDKVGASASDGSVFVLDLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E9GJN8</accession>
    <name>E9GJN8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DAPPUDRAFT_197043</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Daphnia pulex</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="GL732548">
        <property type="protein sequence ID" value="EFX80286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX80286"/>
    <dbReference type="EnsemblMetazoa" id="EFX80286">
        <property type="protein sequence ID" value="EFX80286"/>
        <property type="gene ID" value="DAPPUDRAFT_197043"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_197043"/>
    <dbReference type="eggNOG" id="KOG1335">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_016755_0_3_1"/>
    <dbReference type="InParanoid" id="E9GJN8"/>
    <dbReference type="OMA" id="DAKYGEW"/>
    <dbReference type="OrthoDB" id="581771at2759"/>
    <dbReference type="PhylomeDB" id="E9GJN8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
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    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
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    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
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        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
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        <property type="entry name" value="Lipoamide_DH"/>
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    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
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    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="13">
        <location>
            <begin position="36"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="12">
        <location>
            <begin position="380"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="212"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="352"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="73"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFX80286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="501" mass="53558" checksum="01D7B4C03C0C7DED" modified="2011-04-05" version="1">MQVNILSKLPQNLKVTAAVRNQLANCRWYSDSTEADLVVIGSGPGGYVAAIKAAQLGMKTVCVEKNATLGGTCLNVGCIPSKALLNNSHYYHMAQSEFKNRGIDVTGLSLNLPQMMKAKETAVKSLTGGIAHLFKSNKVTHIRGHGKITGANEVTALKEDGTQEIVRTKNILIATGSEVTPFPGIDIDEEQIVSSTGALCLKTVPEKMIVIGAGVIGLELGSVWSRLGAKVTAVEFMNQIGGLGIDQEMAKSFQRILTKQHMQFKLGTKVLGAQKSGGKIIVNVENVKSAKKEEMDCDVLLVCVGRRPFTKSLGLEEMSIELDQRGRIPVNSRFQSVVPNIYAIGDCILGPMLAHKAEDEGIICVEGIAGGSVHIDYNCVPSVIYTHPEVAWVGKSEEDLKSMGVEYKIGKFPFAANSRAKTNDDTDGMVKILGDKTTDRLLGAHIIGPGAGEMINEAALAMEYGASCEDIARVCHAHPTCSEALREASLAAFSGKAINFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E9GK25</accession>
    <name>E9GK25_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_224833</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732548">
        <property type="protein sequence ID" value="EFX80221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX80221">
        <property type="protein sequence ID" value="EFX80221"/>
        <property type="gene ID" value="DAPPUDRAFT_224833"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_224833"/>
    <dbReference type="HOGENOM" id="CLU_1355879_0_0_1"/>
    <dbReference type="OMA" id="PCKAEER"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="66"/>
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            <begin position="90"/>
            <end position="109"/>
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        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="202" mass="25105" checksum="58BE124632597F93" modified="2011-04-05" version="1">MPRKQENVRRRGKSRRSRSRSREEEEKAEEAEKKPRKQDQNRRRQRRKTSTEDRKEEDEDAKRVRPKKKTRKMPRKKQENVRRREKSRRSRSKTREEERKAEEAKKKPRKQEQKRRRRRSKTPKKDRCTGRNRKKPCKAEERRRRQVPEQDEGVKEHEEEESEEEGEEEEEEDEEHLLKKDTVEEKRRIRGRGNDKSEKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKK1</accession>
    <name>E9GKK1_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_244262</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX80007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX80007">
        <property type="protein sequence ID" value="EFX80007"/>
        <property type="gene ID" value="DAPPUDRAFT_244262"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_244262"/>
    <dbReference type="eggNOG" id="KOG3510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2815029_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GKK1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
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        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX80007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="67" mass="7625" checksum="56AF977DD8A108CA" modified="2011-04-05" version="1">MAIAFNSSRAAGGTSWIGYSASQIMIQWQPPDEEHGNKMITGYMVRYRLHGYGENTPWSNRNMTNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E9GKY8</accession>
    <name>E9GKY8_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_8468</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732550">
        <property type="protein sequence ID" value="EFX79884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79884"/>
    <dbReference type="EnsemblMetazoa" id="EFX79884">
        <property type="protein sequence ID" value="EFX79884"/>
        <property type="gene ID" value="DAPPUDRAFT_8468"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_8468"/>
    <dbReference type="HOGENOM" id="CLU_403480_0_0_1"/>
    <dbReference type="InParanoid" id="E9GKY8"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="PhylomeDB" id="E9GKY8"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX79884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="69" mass="7869" checksum="528518FCC6096EB5" modified="2011-04-05" version="1" fragment="single">CGVCGDIAKSYHFGGLSCDSCKAFFRRSVQNDNYLHFQCCHRGQCVISLSNRKSCQYCRMKRCFAIGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9GLL1</accession>
    <name>E9GLL1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732551">
        <property type="protein sequence ID" value="EFX79671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX79671"/>
    <dbReference type="EnsemblMetazoa" id="EFX79671">
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        <property type="gene ID" value="DAPPUDRAFT_225024"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_225024"/>
    <dbReference type="eggNOG" id="KOG2191">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="InParanoid" id="E9GLL1"/>
    <dbReference type="OMA" id="MTTLANY"/>
    <dbReference type="OrthoDB" id="1167935at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="2">
        <location>
            <begin position="54"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="2">
        <location>
            <begin position="148"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="2">
        <location>
            <begin position="450"/>
            <end position="523"/>
        </location>
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        <location>
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            <end position="452"/>
        </location>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        </source>
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    <sequence length="192" mass="21960" checksum="4E0277E31A413AD6" modified="2011-04-05" version="1">MSCQEPLSGLTRVRRFQQDDAHIFCIMGQIKSEINGALAFLRDIFGFTFQLRLSTRPEKFLGEIETWNHAEKELTESLNEFGDTWQLNPGDGAFYGPKIDITIMDALRRPHQCATIQLEFQLPIRFNLSFINEAGEKEKPVIIHRAILGSVQHMIAILTEIYAGKWPFWLSPRQCVVVLVGPVFHGYAQQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <location evidence="1">Secreted</location>
        </subcellularLocation>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="191" mass="21558" checksum="3197A07504EEF165" modified="2011-04-05" version="1">MISTGIIGATFSTLVDFCAYHPKIWESSINLLSQPSSSELKFDCPPGFIAAPNQSHFPTSNGCGADGLKIDVEYLPYKDQELCCNTHDMCYDKCHIISSMEADVHRGQCDKEFKNCLIKICSFKSWQRYLICPFRIVLTNKFWNENCEQPLIDDREKKCEASVEVLYQSVHGWGFSAYLKAQSQACVCVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GP65</accession>
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    <protein>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2">
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        <name type="common">Water flea</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
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                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
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                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732556">
        <property type="protein sequence ID" value="EFX78585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX78585">
        <property type="protein sequence ID" value="EFX78585"/>
        <property type="gene ID" value="DAPPUDRAFT_320213"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_320213"/>
    <dbReference type="HOGENOM" id="CLU_2252725_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GP65"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX78585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="104" mass="12071" checksum="CC074A9E3C2054E2" modified="2011-04-05" version="1">MSSRPRASTTKRDSSAALFSLQDTNLSKQHKDDNFPFQFDKAFEMDVDAFLYLDSAAQTLKFKSFFAKLEEEAICIKTEKALMMRKIEKLEKEIENRATLHNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPB3</accession>
    <name>E9GPB3_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DAPPUDRAFT_305142</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732556">
        <property type="protein sequence ID" value="EFX78711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78711"/>
    <dbReference type="EnsemblMetazoa" id="EFX78711">
        <property type="protein sequence ID" value="EFX78711"/>
        <property type="gene ID" value="DAPPUDRAFT_305142"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305142"/>
    <dbReference type="eggNOG" id="KOG2199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010104_0_0_1"/>
    <dbReference type="InParanoid" id="E9GPB3"/>
    <dbReference type="OMA" id="AHALCQN"/>
    <dbReference type="OrthoDB" id="906159at2759"/>
    <dbReference type="PhylomeDB" id="E9GPB3"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="SSF48464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SSF50044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="8">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="207"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFX78711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="482" mass="53621" checksum="32DEB7824BF9B663" modified="2011-04-05" version="1">MGIFSGSSPFDLDVEKATDEKNMSENWETILDVCDKVKAITTGPKDCLRAIIKRLYHQNPHVAKQAVKLLDACVSNCHKPFHLEIASRDSEQELYKLIKNKLHPQVASQLKQCLKKWAEGDFKTDSQLSLIPALYNRLRQEGVDFTETTEPVKKTVVNNKDVAAREEEDIAKAIALSLKEAEVTTKVSSSLYPSMTTSAPISPVKERERRKVRALYDFEAAEDNELTFKAGEIIHVIDDSDPNWWKGSNQRGEGLFPANFVSTDLEAEPEVMVARDTSKRVQFNEQVVVATLEETASSEAEVEIDEAKIDRMLHALHEADPTGERNDPEELKMLEDQCGAMGPLIDAELEKLDRRHAHLTKLGSHLIESLDMYRSLMREMPAPPQTHPNMNMGMSVPGYQYPGANVAPIGPVGGMNVSGNMKYPFPQPQAPPQSPSLAPFAPPVSHSATFPPNQVPNPMPYGVVNMGQQPFVNPYSGHPQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E9GPB4</accession>
    <name>E9GPB4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_105067</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732556">
        <property type="protein sequence ID" value="EFX78612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX78612"/>
    <dbReference type="EnsemblMetazoa" id="EFX78612">
        <property type="protein sequence ID" value="EFX78612"/>
        <property type="gene ID" value="DAPPUDRAFT_105067"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_105067"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1035345_0_0_1"/>
    <dbReference type="InParanoid" id="E9GPB4"/>
    <dbReference type="OMA" id="CFINAFC"/>
    <dbReference type="OrthoDB" id="1308998at2759"/>
    <dbReference type="PhylomeDB" id="E9GPB4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX78612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="269" mass="29139" checksum="292E103F669E662D" modified="2011-04-05" version="1">MGVAWWNLQSQLLVAIQKDDVMRAKELLADGVDCDARFNFGSHRRPALCLCVERDSLDLVRLLLDWGCSVNQSDTRGQTALHLAASRGQLGLLQHLLRNKASVRALDEQKRTPLHWAAQHSSPEMALFLLQHQAAVDPLDQDGRTPLLLGLTAHFKKGKKQDLLSFYLLLACQNPSSSATAQQLLRYGANARAVDSLGNSALHLAADPPLMKALIASGAAVNASNQAGLTPLHLAVRHTSTSRVEIVSLLAQAGCQLDQPTPLGIFINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9GQN4</accession>
    <name>E9GQN4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_246495</name>
    </gene>
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    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="116"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX77629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="166" mass="19225" checksum="B8D357C4449CF34C" modified="2011-04-05" version="1">MRGLEGPSQSVTRGTDIILHCRYDLEAGDRLYAVKWFHGTREFYRFQPELQPPSRSFPIEDVYVDVESSNAEKLVIRHVVPGTSGVYRCEVSAEETFETDYREMNITIEDAPLGDPVIYNIQSRYAIGAELRINCKSFDYRPAARLHWIINGKAVRNRIINHRTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9GS80</accession>
    <name>E9GS80_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PBPe domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_247312</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732561">
        <property type="protein sequence ID" value="EFX77665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX77665"/>
    <dbReference type="EnsemblMetazoa" id="EFX77665">
        <property type="protein sequence ID" value="EFX77665"/>
        <property type="gene ID" value="DAPPUDRAFT_247312"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_247312"/>
    <dbReference type="eggNOG" id="KOG1052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007257_4_2_1"/>
    <dbReference type="InParanoid" id="E9GS80"/>
    <dbReference type="OrthoDB" id="460569at2759"/>
    <dbReference type="PhylomeDB" id="E9GS80"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="4">
        <location>
            <begin position="108"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX77665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="324" mass="36162" checksum="618BC9337A89B6B0" modified="2011-04-05" version="1">MQDNISFYSILDVNVTTLEDGGPKLPGIISYATRGECDVILAVIRQTSERLRLVELVHPWMYTSMAFIIPMPEVSQNNVDAVVKPFQFWDRSVIKEKNTAILPAVGMIENISMYVVGTLLNQGGYIPSKFTPIRLVVGAWCLLTLVMLNVYNGVLISYVTETGRPQPLITSFYDVPHDSNILLVVDKGLATDIVISSSQQGLYKAMKDKLAAHPNSRCLSTQQCVDLSAIGLKAAIRKDYMETRQCKLTIAGEAPFMKQAAGWGLAKNSPYLEEFNRGTARLFELGLISLWQNWYEPNSKPCYDDRKNGGENKSKEKSLGHLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GTU5</accession>
    <name>E9GTU5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_305890</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732564">
        <property type="protein sequence ID" value="EFX77135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX77135">
        <property type="protein sequence ID" value="EFX77135"/>
        <property type="gene ID" value="DAPPUDRAFT_305890"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_305890"/>
    <dbReference type="HOGENOM" id="CLU_2640630_0_0_1"/>
    <dbReference type="OrthoDB" id="1849971at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX77135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="77" mass="9228" checksum="A1CD4DA8E0C64A24" modified="2011-04-05" version="1">MCMMNLFSFVNYYSPHQLCNLYTYDVRRLKISSSIHECYDEPSLDSSMSFVTRFTYTHTHIILYTGYNNKRPLLMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E9GUP5</accession>
    <name>E9GUP5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_54859</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL732566">
        <property type="protein sequence ID" value="EFX76769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76769">
        <property type="protein sequence ID" value="EFX76769"/>
        <property type="gene ID" value="DAPPUDRAFT_54859"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_54859"/>
    <dbReference type="eggNOG" id="ENOG502TFBJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2765079_0_0_1"/>
    <dbReference type="InParanoid" id="E9GUP5"/>
    <dbReference type="OMA" id="DARIYGM"/>
    <dbReference type="OrthoDB" id="822378at2759"/>
    <dbReference type="PhylomeDB" id="E9GUP5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX76769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="70" mass="7657" checksum="5B9EB46CFE5ACD55" modified="2011-04-05" version="1" fragment="single">GMIDTTDILIKQPLRHLAAYTNRKSTTSVKIQGVCDSRKCFLDISAGWPGSMHDARIYGMSSLSGAINEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9GUW1</accession>
    <name>E9GUW1_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_231190</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732567">
        <property type="protein sequence ID" value="EFX76562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="E9GUW1"/>
    <dbReference type="STRING" id="6669.EFX76562"/>
    <dbReference type="EnsemblMetazoa" id="EFX76562">
        <property type="protein sequence ID" value="EFX76562"/>
        <property type="gene ID" value="DAPPUDRAFT_231190"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_231190"/>
    <dbReference type="eggNOG" id="KOG0394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_6_1"/>
    <dbReference type="InParanoid" id="E9GUW1"/>
    <dbReference type="OMA" id="DGDNCAC"/>
    <dbReference type="OrthoDB" id="1172019at2759"/>
    <dbReference type="PhylomeDB" id="E9GUW1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX76562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="208" mass="23535" checksum="123830BD196C9597" modified="2011-04-05" version="1">MASRRKILLKVIILGDSGVGKTSLMNQYVNRKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTSPTSFKDLDSWRDEFLIQASPRDPENFPFVVLGNKVDLENRAVSTKRAQQWCHAKNDIPYFETSAKEGINVEQAFQTIARNALAQETQVDLYNEFPEQIKLTPGDQRGNGRQDSCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9GV07</accession>
    <name>E9GV07_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_248684</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
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            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732567">
        <property type="protein sequence ID" value="EFX76697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76697">
        <property type="protein sequence ID" value="EFX76697"/>
        <property type="gene ID" value="DAPPUDRAFT_248684"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_248684"/>
    <dbReference type="HOGENOM" id="CLU_200702_0_0_1"/>
    <dbReference type="PhylomeDB" id="E9GV07"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX76697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="55" mass="6279" checksum="6DE104119FB56656" modified="2011-04-05" version="1">MANCRQHSCYPSSDFSNPVLLVLPSSVRFHLYVLFPARQPPAIVRGSLWLRVRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E9GW69</accession>
    <name>E9GW69_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_306264</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732569">
        <property type="protein sequence ID" value="EFX76295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76295"/>
    <dbReference type="ESTHER" id="dappu-e9gw69">
        <property type="family name" value="SERHL"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX76295">
        <property type="protein sequence ID" value="EFX76295"/>
        <property type="gene ID" value="DAPPUDRAFT_306264"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306264"/>
    <dbReference type="eggNOG" id="KOG1454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_8_2_1"/>
    <dbReference type="InParanoid" id="E9GW69"/>
    <dbReference type="OMA" id="FESPENF"/>
    <dbReference type="OrthoDB" id="1285824at2759"/>
    <dbReference type="PhylomeDB" id="E9GW69"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="62"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX76295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="334" mass="37152" checksum="53E1798EC32C7318" modified="2011-04-05" version="1">MANDAEKLLFRMQHIIPQQLSSVLNVHDKETTSSNVNPMEIEFQMTWGKVAAKVWGPPDGRPVFALHGWLDNAATFDALIPLLPQNLRIVAVDTAGHGLSDHYPPDIAYNFFDCLVAIERLAGLLKWKKFSFIGHSMGAAMGMLYAGVFPEKVDTLVCLDLARAEVTRPKTVGYRLRKTTEKLLKYEAAIVAGPEKPFSYDAAIERSITGSFGSLDKNACDLLFKRGLKRVDGGHVFRRDRRLMAAPLTLTPKEDQLEMAKEVTANVLVIKFAQGPDFESPENFMEHVKTLKTKAKNVRYVEVEGAHHVHLTHPDRIATIISEFFNAPSSGGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9GW86</accession>
    <name>E9GW86_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Maternal transcript 89Ba</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DAPPUDRAFT_249247</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">May be associated with rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732569">
        <property type="protein sequence ID" value="EFX76313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX76313"/>
    <dbReference type="EnsemblMetazoa" id="EFX76313">
        <property type="protein sequence ID" value="EFX76313"/>
        <property type="gene ID" value="DAPPUDRAFT_249247"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_249247"/>
    <dbReference type="eggNOG" id="KOG2054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003502_0_1_1"/>
    <dbReference type="InParanoid" id="E9GW86"/>
    <dbReference type="OMA" id="NPHGGKE"/>
    <dbReference type="OrthoDB" id="176625at2759"/>
    <dbReference type="PhylomeDB" id="E9GW86"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="PTHR17972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nrap" evidence="9">
        <location>
            <begin position="227"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap_D2" evidence="10">
        <location>
            <begin position="369"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap_D3" evidence="11">
        <location>
            <begin position="507"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap_D4" evidence="12">
        <location>
            <begin position="678"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap_D5" evidence="13">
        <location>
            <begin position="880"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap_D6" evidence="14">
        <location>
            <begin position="1058"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFX76313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1339" mass="151426" checksum="6496C15AF32DCB33" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9GX18</accession>
    <name>E9GX18_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_322816</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732571">
        <property type="protein sequence ID" value="EFX75995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX75995"/>
    <dbReference type="EnsemblMetazoa" id="EFX75995">
        <property type="protein sequence ID" value="EFX75995"/>
        <property type="gene ID" value="DAPPUDRAFT_322816"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_322816"/>
    <dbReference type="eggNOG" id="KOG0740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_10_1"/>
    <dbReference type="InParanoid" id="E9GX18"/>
    <dbReference type="OMA" id="DARCAVW"/>
    <dbReference type="OrthoDB" id="1176820at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Vps4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="375"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX75995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="617" mass="69493" checksum="15E51F08B42B05B5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9GZS9</accession>
    <name>E9GZS9_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_323794</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732578">
        <property type="protein sequence ID" value="EFX75047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX75047">
        <property type="protein sequence ID" value="EFX75047"/>
        <property type="gene ID" value="DAPPUDRAFT_323794"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_323794"/>
    <dbReference type="HOGENOM" id="CLU_117333_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX75047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="148" mass="16921" checksum="80BF13444375F800" modified="2011-04-05" version="1">MPRSKRVRKSVNYAESDLSSLTEPSSQVYDTSRRRSRRARDQLPFSPASPSVVEIVSERATSRSSMPPLEPIWPPTPLPAEEENFRAPSPYDFVYQQELEASYLGALLTSQTTFERIAAYRAFRTQMDTLLNILSPDDEYSVIPPDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0E5</accession>
    <name>E9H0E5_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoserine transaminase</fullName>
            <ecNumber evidence="8">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_306988</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="8"/>
    <dbReference type="EMBL" id="GL732580">
        <property type="protein sequence ID" value="EFX74793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74793"/>
    <dbReference type="EnsemblMetazoa" id="EFX74793">
        <property type="protein sequence ID" value="EFX74793"/>
        <property type="gene ID" value="DAPPUDRAFT_306988"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_306988"/>
    <dbReference type="eggNOG" id="KOG2790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034866_0_2_1"/>
    <dbReference type="InParanoid" id="E9H0E5"/>
    <dbReference type="OMA" id="GYRASMY"/>
    <dbReference type="OrthoDB" id="1357311at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00611">
        <property type="entry name" value="PSAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PTHR43247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01364">
        <property type="entry name" value="serC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="Aminotran_5" evidence="10">
        <location>
            <begin position="6"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX74793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="361" mass="40133" checksum="1A70C37AFD56A4E4" modified="2011-04-05" version="1">MSSKIINFSPGPSKLPEDVLLQVQRELLDYHGTGISVMEMSHRSPEFMKIVTDAQENIRQLLNIPSDYTILFMAGGGTGQFAAVPLNLLPSTGKAVYLNTGTWSAKAAKEASKYGCVIEIKPDFKSSSNEIQWDHDEDVSYFYYCSNETVHGIELNFIPDTHGIPLVADMSSNILTKDFDITKFALVFAGAQKNIGPAGVTLVIIRNDLLGKQSVHCPSVLNYSVMAKENSLHNTPPCFNLYVMALVFQWISEQGGVKVMEQRSNAKSQMVYEVIDHSSGFYSCPVPASVRSRVNIPFRIQNGNEDLEKQFVDEAKRRNMIQLKGHRSVGGIRASLYNAVTVDEVSLLTAFMKDFMKSKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E9H0T0</accession>
    <name>E9H0T0_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DAPPUDRAFT_129136</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL732582">
        <property type="protein sequence ID" value="EFX74514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX74514"/>
    <dbReference type="EnsemblMetazoa" id="EFX74514">
        <property type="protein sequence ID" value="EFX74514"/>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Crease T.J."/>
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                <person name="Lucas S.M."/>
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                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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    </evidence>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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        <recommendedName>
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    </gene>
    <organism evidence="7">
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    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="EFX72203"/>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="EFX72203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="52" mass="6112" checksum="0A85ECEA59B36A77" modified="2011-04-05" version="1">MGFPDIRQDRDKPILQLRQHRLFADGTKRENNTMWMVPIEIATSRSPTTPNM</sequence>
</entry>
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    <accession>E9H8F4</accession>
    <name>E9H8F4_DAPPU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
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                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732604">
        <property type="protein sequence ID" value="EFX71939.1"/>
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    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71939">
        <property type="protein sequence ID" value="EFX71939"/>
        <property type="gene ID" value="DAPPUDRAFT_326666"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_326666"/>
    <dbReference type="HOGENOM" id="CLU_1857307_0_0_1"/>
    <dbReference type="OrthoDB" id="1809394at2759"/>
    <dbReference type="PhylomeDB" id="E9H8F4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX71939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="138" mass="14954" checksum="7AC6F9BBE7ED8551" modified="2011-04-05" version="1">MNIHESGNEYLATLTTCTIGRRRRGLFYDDAATQGRNRRGLFYNDEQVENKEGETFLPLEAKIGEPTLEVANTPIDESSLIPLEVESGFTVPDGSPNRFLLAFGTSTLTSIVVTTSTSTLTAICSSTTGFPLCVNVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9H8N0</accession>
    <name>E9H8N0_DAPPU</name>
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        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX71917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71917"/>
    <dbReference type="EnsemblMetazoa" id="EFX71917">
        <property type="protein sequence ID" value="EFX71917"/>
        <property type="gene ID" value="DAPPUDRAFT_308645"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_308645"/>
    <dbReference type="eggNOG" id="KOG4328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_426585_0_0_1"/>
    <dbReference type="InParanoid" id="E9H8N0"/>
    <dbReference type="OMA" id="KSEPECI"/>
    <dbReference type="OrthoDB" id="753973at2759"/>
    <dbReference type="PhylomeDB" id="E9H8N0"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033052">
        <property type="entry name" value="Cmr1/WDR76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="PTHR14773:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX71917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="572" mass="64900" checksum="C4CA3D1A78BAA382" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E9H976</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_59833</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Branchiopoda</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732607">
        <property type="protein sequence ID" value="EFX71747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71747"/>
    <dbReference type="EnsemblMetazoa" id="EFX71747">
        <property type="protein sequence ID" value="EFX71747"/>
        <property type="gene ID" value="DAPPUDRAFT_59833"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_59833"/>
    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_1890926_0_0_1"/>
    <dbReference type="InParanoid" id="E9H976"/>
    <dbReference type="OMA" id="YCETRVE"/>
    <dbReference type="OrthoDB" id="774159at2759"/>
    <dbReference type="PhylomeDB" id="E9H976"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX71747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="135" mass="15433" checksum="2EBFB87412097660" modified="2011-04-05" version="1" fragment="single">VRTMARRTLLDGIYPIYALHCDYCLTTSGPAIMRVVVISSDCEKIYETFVRQDNLIMQFGTRFVRISLSDLLLTWRQPSDVQHKLSELICDKTILIGHVVQYALLALRMTHDTVVDTSVVFRSCQPAIATRKSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9D7</accession>
    <name>E9H9D7_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
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            <taxon>Anomopoda</taxon>
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            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
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                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX71673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblMetazoa" id="EFX71673">
        <property type="protein sequence ID" value="EFX71673"/>
        <property type="gene ID" value="DAPPUDRAFT_326989"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG2408">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_006087_2_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:response to oxidative stress"/>
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        <source>
            <dbReference type="EMBL" id="EFX71673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="491" mass="55259" checksum="50B131D5F93FD79D" modified="2011-04-05" version="1">MQWGQFLDHDLTSTPTFTKSDGSAFLCCSAEQTGVNVAPPHPECLPIAIARNDPVFNPLGNGQVTCMNFIRSTFGNNLDGSVPRMRSQINALTHWIDGSNVYGSSAAKARSLRDPTSGRGRLRTSITNLGRQMLPLGNCSTRCFHAGDSRVNEQPLLTVMHTLWLREHNRIAENLWRIFPRQTDEFYFQHARRIVIAEMQHIIYNEYLPVIIGPKMAAKVNSENGYSNTLNPAVFTEFSTAAFRMGHSQLRSFIRLFERDRSDSRESYQLSDSFDDPSRLLSSNFMDNALRGLLQVPAEEVDSFFAFDITSQLFKPKGATLGLDLTALNIQRGRDHGLPTYAKMLAFFGQPFPSRFDQLLPLIPQQVVNAMKSVYESVQDIDLFIGGVTEYPMPDAVLGPTFANIFAYQFSNLRRSDRFFYKFNVDQPTGFRSGQLAEIQKVSLARIICDNSDGTIGQIPPKAFRTPHELYNRFAPCSSIPGIDFSQMFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9H9Z9</accession>
    <name>E9H9Z9_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_111730</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732610">
        <property type="protein sequence ID" value="EFX71432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX71432">
        <property type="protein sequence ID" value="EFX71432"/>
        <property type="gene ID" value="DAPPUDRAFT_111730"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_111730"/>
    <dbReference type="HOGENOM" id="CLU_779053_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="356" mass="39437" checksum="92AFA1E2D81AE73A" modified="2011-04-05" version="1">MGYNFGPRMFYYCMKKATEWHDKKKKKPQSEQSVLELADQVNRQTLLADQVASKILLSLNQKLDVLAASQGTKSNKKSSKHPHDEEGARDHSSLDEAGGPATGLMVSSQLSEGDDFYHRIANWDLYMAEGVFGLATVAVAKITLWPPLQYNLREKWDWHSRSKGNKKSSKHLHDEEGARDYSSSDEAGGPATGTPIGPIDSFNQSGKGRWVEDNELDQFAEEITNLVVTTELTFLKGSFWMLLCILTKYFIWQPAKYWFYVYKRKYSKKPDDSSSAAAESSAAAESSAAAESSAAAESSAAAESSAAAAAQPNISIIEQVLMQQQTLLREMRDMMVERVQKKFKVPQTGTGANNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9HAA2</accession>
    <name>E9HAA2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_255880</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732611">
        <property type="protein sequence ID" value="EFX71272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="EFX71272"/>
        <property type="gene ID" value="DAPPUDRAFT_255880"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_255880"/>
    <dbReference type="eggNOG" id="KOG4441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_480821_0_0_1"/>
    <dbReference type="InParanoid" id="E9HAA2"/>
    <dbReference type="OrthoDB" id="864323at2759"/>
    <dbReference type="PhylomeDB" id="E9HAA2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF54695"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="153"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="437"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX71272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="562" mass="63858" checksum="B932C96D92AFD27B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9HAU6</accession>
    <name>E9HAU6_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PBPe domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_327467</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732613">
        <property type="protein sequence ID" value="EFX71155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX71155"/>
    <dbReference type="EnsemblMetazoa" id="EFX71155">
        <property type="protein sequence ID" value="EFX71155"/>
        <property type="gene ID" value="DAPPUDRAFT_327467"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_327467"/>
    <dbReference type="eggNOG" id="KOG1052">
        <property type="taxonomic scope" value="Eukaryota"/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
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                <person name="Robertson H.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732625">
        <property type="protein sequence ID" value="EFX70132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX70132">
        <property type="protein sequence ID" value="EFX70132"/>
        <property type="gene ID" value="DAPPUDRAFT_112991"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_112991"/>
    <dbReference type="HOGENOM" id="CLU_1715078_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX70132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="153" mass="17124" checksum="324A3C10A83CD4D8" modified="2011-04-05" version="1">MEVMEVMEVAIRNVCSVERGILFGDYFAVNAGLPVSPAHLVPDEDWDMESGESPAPLPKEKSHPKKAAQTPNSMKLPIISSWSLVSTLQLSLIWNHRGAWGKSWLELGWKTTEVRSNLTLPRLATIYRSNRSRSLGNEMGNDLRGFSLYPNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9HE17</accession>
    <name>E9HE17_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_113088</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732626">
        <property type="protein sequence ID" value="EFX70032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX70032"/>
    <dbReference type="EnsemblMetazoa" id="EFX70032">
        <property type="protein sequence ID" value="EFX70032"/>
        <property type="gene ID" value="DAPPUDRAFT_113088"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_113088"/>
    <dbReference type="eggNOG" id="KOG0019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_0_3_1"/>
    <dbReference type="InParanoid" id="E9HE17"/>
    <dbReference type="OMA" id="SFQMEIA"/>
    <dbReference type="OrthoDB" id="924636at2759"/>
    <dbReference type="PhylomeDB" id="E9HE17"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX70032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="145" mass="16044" checksum="D1B90B1FD547EC21" modified="2011-04-05" version="1">MEDEAETLTFQAKIAQLMSLIINTFYNKIHYESLTDPSKLDSGKDLKIKIVPNKNDSLSWIRNGIGMIKADLVNNLGTIAKSGTKAFMEALSAGADISMIGQFGFIPSTMMMSSMFGNLQLVVFFTIKPDHREPMGRGTKIVLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E9HEB5</accession>
    <name>E9HEB5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_61794</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732628">
        <property type="protein sequence ID" value="EFX69928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX69928"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_61794"/>
    <dbReference type="eggNOG" id="KOG3434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105624_0_1_1"/>
    <dbReference type="InParanoid" id="E9HEB5"/>
    <dbReference type="OMA" id="YQLRFYN"/>
    <dbReference type="OrthoDB" id="1594080at2759"/>
    <dbReference type="PhylomeDB" id="E9HEB5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_L22e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_L22e_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="PTHR10064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX69928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="109" mass="12713" checksum="004DB7E26E1C2594" modified="2011-04-05" version="1" fragment="single">KGYKGKKLNLKFTIDCTHPVEDGIMNAADFETYLKQHIKLNKKVGNLGTHIQTELAKSKIIVSSDVPFSKRYLKYLTKRYLKKNNLRDWLRVVANGKTSYELRYFNVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9HF85</accession>
    <name>E9HF85_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_328956</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
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                <person name="Tsuchiya D."/>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
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                <person name="Geiler-Samerotte K.A."/>
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                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pritham E.J."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Yamagata H."/>
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                <person name="Lucas S.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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</entry>
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                <person name="Thomas W.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX67435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="169" mass="20530" checksum="DF80F02C1FA874A7" modified="2011-04-05" version="1">MQCLHCVIKDCVITVTTSGDKVTWLFFLRIRLLTTRFVNEKYVNEPSNNINHIYALNDRVNRHWFPEDIPRRAYHSAKEEQFRKYTESDLDMWKWELRYDEYVPLQINQRALSFWIDKARTPSNRRHCTPCEGINPLNHMNCTAYPHYLYEGGTRTDHYSYTWWPQHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E9HLP8</accession>
    <name>E9HLP8_DAPPU</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_261796</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732680">
        <property type="protein sequence ID" value="EFX67323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67323">
        <property type="protein sequence ID" value="EFX67323"/>
        <property type="gene ID" value="DAPPUDRAFT_261796"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_261796"/>
    <dbReference type="HOGENOM" id="CLU_115558_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX67323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="146" mass="16310" checksum="2472A133E8879A52" modified="2011-04-05" version="1">MSSLENQQILEQLSAQVRVVQAQVSEASPKPRETTGTEPYSRRYTRSSTDGEFEPELFFKVLTVVSKNFDLISKLKPTATEVIELNAAGLREITVELSEDDSSTMSASVMPIEVPYWVSDLHHLEFVTVPGVFHPSLQRSSNFTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E9HM31</accession>
    <name>E9HM31_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DAPPUDRAFT_331304</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="EMBL" id="GL732684">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX67167"/>
    <dbReference type="EnsemblMetazoa" id="EFX67167">
        <property type="protein sequence ID" value="EFX67167"/>
        <property type="gene ID" value="DAPPUDRAFT_331304"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_331304"/>
    <dbReference type="eggNOG" id="KOG3714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017286_2_1_1"/>
    <dbReference type="InParanoid" id="E9HM31"/>
    <dbReference type="OrthoDB" id="681837at2759"/>
    <dbReference type="PhylomeDB" id="E9HM31"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005128583" description="Metalloendopeptidase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="81"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFX67167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="255" mass="28323" checksum="95B87EB1A0C8FA91" modified="2011-04-05" version="1">MSTQLVARSVMLALMVWSCCWTIQVIRGTPVGTPELDRDCGLPLTEAELACVPTFSKAAPDDFPTSEGDDIVSLPNLPNKNAFVDRKWPNASAIPYVIDSAFDVKGRCAIGYAMTQYHKISCIRFVPRTAQTDYVKINKLDTTVFSCSSSGLGFYKGRGAHHITLSPSCYQSQPGTIIHELMHRIGFAHEHNRPDRDKFVNILWDKIIDKGSVMHYPLGIKMTTKLNTNGAVIGQRDGLSRNDVIKLVLMYCLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E9HM43</accession>
    <name>E9HM43_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_115653</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL732684">
        <property type="protein sequence ID" value="EFX67207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX67207">
        <property type="protein sequence ID" value="EFX67207"/>
        <property type="gene ID" value="DAPPUDRAFT_115653"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_115653"/>
    <dbReference type="HOGENOM" id="CLU_021098_1_0_1"/>
    <dbReference type="InParanoid" id="E9HM43"/>
    <dbReference type="OrthoDB" id="251112at2759"/>
    <dbReference type="PhylomeDB" id="E9HM43"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
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                <person name="Hatcher P."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Ye Y."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
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                <person name="Yamada T."/>
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                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX65784.1"/>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Thomas W.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="Kunitz_BPTI_sf"/>
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        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
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        <property type="entry name" value="SSF57362"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX65647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="51" mass="5785" checksum="6FD99CCCC022E113" modified="2011-04-05" version="1" fragment="single">CSQPAETGHCWALFPRYFYNVSSRSCEEFISGGCEGNENNYESVQECSQHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E9HS61</accession>
    <name>E9HS61_DAPPU</name>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name evidence="3" type="ORF">DAPPUDRAFT_65490</name>
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        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX65423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX65423"/>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_65490"/>
    <dbReference type="eggNOG" id="KOG4563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1087923_0_0_1"/>
    <dbReference type="InParanoid" id="E9HS61"/>
    <dbReference type="OMA" id="VQHRINI"/>
    <dbReference type="OrthoDB" id="1176629at2759"/>
    <dbReference type="PhylomeDB" id="E9HS61"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
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        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX65423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="229" mass="25895" checksum="4809F982C3ABC221" modified="2011-04-05" version="1" fragment="single">AMNLLEQGRRYLHVSDLPSAIAALAESAELLVKRYGANADECAESFYYLGMAFHEKHRADSCVLDEPFTYTIRPLSLPSGDKAEEEDGESEDEKNGDEEESEEEDVSEKSTNGDKVDSVMGDDDDEKPILELAWKMFEQAKQIYESQNLPTLFRLAEVELESENFDLAIEDLQKYLKIQKASLPPDSRSMSETYYKLGVAFASISKFKDAVRSFESSAKIVQHRINILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E9HS78</accession>
    <name>E9HS78_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cullin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_303634</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
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        <property type="protein sequence ID" value="EFX65408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX65408"/>
    <dbReference type="EnsemblMetazoa" id="EFX65408">
        <property type="protein sequence ID" value="EFX65408"/>
        <property type="gene ID" value="DAPPUDRAFT_303634"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303634"/>
    <dbReference type="eggNOG" id="KOG2284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1290123_0_0_1"/>
    <dbReference type="InParanoid" id="E9HS78"/>
    <dbReference type="OMA" id="SSWENAF"/>
    <dbReference type="OrthoDB" id="1040292at2759"/>
    <dbReference type="PhylomeDB" id="E9HS78"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX65408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="214" mass="25028" checksum="D2BF97338E2C6EBE" modified="2011-04-05" version="1">MSLEPRANDFGSTWANLREVLKSVVTLETISKSSWENAFSNVYFLCVATEKRAETYEQLYQETQEFLEEHVKSLLTRVNQKSQETRLSEYYTIWLQYSKGMEDVNNLYKYLNDKYIIPQRTAVLCGTVHCMMIIEELGLHLWKKYVIAPLKAEMLTLVLGALHDDRTGLSMTFKEKEIINGVLQSLVAVEKYKKKENSLKLLEMIFEGQFLEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>E9HV40</accession>
    <name>E9HV40_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DAPPUDRAFT_266497</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="268" mass="29788" checksum="B099EACCF95E4F34" modified="2011-04-05" version="1">MRIAYQEVLLMHQESEHLVIVANEVRAAASIASTTAFNYLEKPTSQKNKWKDCEEGVQGQLTLYALEFNISNSIAQALNRGVLGSIPESDNFLVDPSTVDEINNALKANKKNKAPGRISKEVSSLKPAAIIAYDLEKAYDLVNRDVLWEVMTAMGYPPFCLSRGIDGIEHYGKRIKVRATERAAAVYWLGQHLKNLLQQIIQPKFNATHSSHPYFTTALSTITDLLKAGIFTSSTVSNHRATYNHLIANLGQPGRTEVAKPYLDWASI</sequence>
</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_266703"/>
    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="63" mass="7172" checksum="E7EAF0C32CD1AAA2" modified="2011-04-05" version="1">MFLSIACISFYITIFMESQSHFLQEPQTKKKSVTPILAITPDIRPGRRLTSKVGQPKLPKSHK</sequence>
</entry>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Patwardhan R.P."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
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                <person name="Andrews J."/>
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                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="DAPPUDRAFT_266858"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_266858"/>
    <dbReference type="HOGENOM" id="CLU_2796556_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
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</entry>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
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                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
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                <person name="Manak J.R."/>
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                <person name="Pangilinan J."/>
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                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
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                <person name="Tsuchiya D."/>
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                <person name="Vos H."/>
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                <person name="Yamagata H."/>
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                <person name="Crease T.J."/>
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                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="54" mass="6245" checksum="DCFCDBB8AE086406" modified="2011-04-05" version="1">MRCAGFPLESSCLGVQLKVRGKLHVRLNMTPRPIANKYREGKLKRTLKREFKST</sequence>
</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
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                <person name="Souvorov A."/>
                <person name="Sung W."/>
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                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Boore J.L."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733397">
        <property type="protein sequence ID" value="EFX62764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62764">
        <property type="protein sequence ID" value="EFX62764"/>
        <property type="gene ID" value="DAPPUDRAFT_269765"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_269765"/>
    <dbReference type="HOGENOM" id="CLU_2778411_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFX62764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="69" mass="7808" checksum="86A94B6BF0152230" modified="2011-04-05" version="1">METTLPTTIFIDSEDSFHFSLRPVQSHVLVIHQIGQENLSPYGFGLTLKMNIEASRFGNHTVHQIPEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E9I0I6</accession>
    <name>E9I0I6_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_336880</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="GL733551">
        <property type="protein sequence ID" value="EFX62495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX62495">
        <property type="protein sequence ID" value="EFX62495"/>
        <property type="gene ID" value="DAPPUDRAFT_336880"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_336880"/>
    <dbReference type="HOGENOM" id="CLU_004877_1_0_1"/>
    <dbReference type="PhylomeDB" id="E9I0I6"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX62495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="580" mass="64881" checksum="987B87B5E9350323" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E9I3P4</accession>
    <name>E9I3P4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DAPPUDRAFT_273773</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL734677">
        <property type="protein sequence ID" value="EFX61386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX61386"/>
    <dbReference type="EnsemblMetazoa" id="EFX61386">
        <property type="protein sequence ID" value="EFX61386"/>
        <property type="gene ID" value="DAPPUDRAFT_273773"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_273773"/>
    <dbReference type="eggNOG" id="KOG0019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133449_0_0_1"/>
    <dbReference type="InParanoid" id="E9I3P4"/>
    <dbReference type="PhylomeDB" id="E9I3P4"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFX61386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="107" mass="12187" checksum="D93DC234095C37B1" modified="2011-04-05" version="1" fragment="single">MERIMKAQALRDTSTMGYMAAKKHLEINSDHPIVKVLRVKAEADKNDKAVKDLFMLLFETSAVIWFLLGRARHDVPAGGEEAKAEEEIPPLENDEENASRRRKAIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E9I3Z4</accession>
    <name>E9I3Z4_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_274207</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL734826">
        <property type="protein sequence ID" value="EFX61286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="EFX61286">
        <property type="protein sequence ID" value="EFX61286"/>
        <property type="gene ID" value="DAPPUDRAFT_274207"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_274207"/>
    <dbReference type="HOGENOM" id="CLU_2869845_0_0_1"/>
    <dbReference type="OrthoDB" id="1357597at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="PTHR12770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX61286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="64" mass="6928" checksum="7D3E5620F4ECE8E3" modified="2011-04-05" version="1">MEARQGNLADVSAKDGSQGTLLLVFANLKAVKAVTMETLNRARYMIILKQFASTKSVASVKEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E9I697</accession>
    <name>E9I697_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pept_C1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DAPPUDRAFT_9835</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL736292">
        <property type="protein sequence ID" value="EFX60484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX60484"/>
    <dbReference type="EnsemblMetazoa" id="EFX60484">
        <property type="protein sequence ID" value="EFX60484"/>
        <property type="gene ID" value="DAPPUDRAFT_9835"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_9835"/>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1699874_0_0_1"/>
    <dbReference type="OrthoDB" id="1275401at2759"/>
    <dbReference type="PhylomeDB" id="E9I697"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pept_C1" evidence="2">
        <location>
            <begin position="64"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFX60484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="155" mass="16703" checksum="122ECE44E81DC5D7" modified="2011-04-05" version="1" fragment="single">CGSCWAIAACTALGARMSKECGRGYPLDERAVEDIMVNAQGSRGCQGGSLASAYRYACNTGLLTQQGRMRIRHAVNIAPTDRCEIKHAIASRGPVAAHMMEYPSLRKVTSDEVAWQPQPTELPINGHAVVLFGWDDLAGGWLVLNSWGGEWGNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRP5</accession>
    <name>E9FRP5_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DAPPUDRAFT_309508</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GGA protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732523">
        <property type="protein sequence ID" value="EFX90451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX90451"/>
    <dbReference type="EnsemblMetazoa" id="EFX90451">
        <property type="protein sequence ID" value="EFX90451"/>
        <property type="gene ID" value="DAPPUDRAFT_309508"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_309508"/>
    <dbReference type="eggNOG" id="KOG1086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015010_0_0_1"/>
    <dbReference type="InParanoid" id="E9FRP5"/>
    <dbReference type="OMA" id="CIMLMFA"/>
    <dbReference type="OrthoDB" id="594067at2759"/>
    <dbReference type="PhylomeDB" id="E9FRP5"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041198">
        <property type="entry name" value="GGA_N-GAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18308">
        <property type="entry name" value="GGA_N-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="SSF48464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="SSF49348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="8">
        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="10">
        <location>
            <begin position="171"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="9">
        <location>
            <begin position="558"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="194"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFX90451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="683" mass="75061" checksum="2B9384FE47EA70C4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E9FRY2</accession>
    <name>E9FRY2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="1">7.2.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DAPPUDRAFT_300029</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="1"/>
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        <property type="protein sequence ID" value="EFX90405.1"/>
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    </dbReference>
    <dbReference type="STRING" id="6669.EFX90405"/>
    <dbReference type="EnsemblMetazoa" id="EFX90405">
        <property type="protein sequence ID" value="EFX90405"/>
        <property type="gene ID" value="DAPPUDRAFT_300029"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_300029"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_1_1"/>
    <dbReference type="InParanoid" id="E9FRY2"/>
    <dbReference type="OMA" id="IEKTGYE"/>
    <dbReference type="OrthoDB" id="649559at2759"/>
    <dbReference type="PhylomeDB" id="E9FRY2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
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        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
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        <property type="entry name" value="HMA_dom"/>
    </dbReference>
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        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF55008"/>
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    </dbReference>
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        <property type="entry name" value="SSF56784"/>
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    </dbReference>
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        <property type="entry name" value="SSF81653"/>
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    </dbReference>
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        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="557"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="984"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1012"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="200"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX90405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="1124" mass="121941" checksum="89C00E1B40634837" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSN2</accession>
    <name>E9FSN2_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DAPPUDRAFT_1152</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="EFX89231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89231"/>
    <dbReference type="EnsemblMetazoa" id="EFX89231">
        <property type="protein sequence ID" value="EFX89231"/>
        <property type="gene ID" value="DAPPUDRAFT_1152"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_1152"/>
    <dbReference type="eggNOG" id="KOG2137">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_008724_2_0_1"/>
    <dbReference type="InParanoid" id="E9FSN2"/>
    <dbReference type="OMA" id="MAHKCIP"/>
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    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
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    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFX89231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="617" mass="69329" checksum="AAA16306C18D7225" modified="2011-04-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E9FSV2</accession>
    <name>E9FSV2_DAPPU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DAPPUDRAFT_310213</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89753"/>
    <dbReference type="EnsemblMetazoa" id="EFX89753">
        <property type="protein sequence ID" value="EFX89753"/>
        <property type="gene ID" value="DAPPUDRAFT_310213"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_310213"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025356_2_0_1"/>
    <dbReference type="InParanoid" id="E9FSV2"/>
    <dbReference type="OMA" id="CIGAVNR"/>
    <dbReference type="OrthoDB" id="663893at2759"/>
    <dbReference type="PhylomeDB" id="E9FSV2"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFX89753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="454" mass="49668" checksum="5D0B9DC202FD8D86" modified="2011-04-05" version="1">MEIDRKFVNVLILGVAFMLIFTAFQTMGNIQQTVIKSITQEDPSFIADGFTSLAIIYAVLSISNWISPSIISVIGPKWSMIVGGFFYSLYIGSFFLQQSWALYTCSALLGFGAALIWTGQGNYLTLNSDGTNISRNSGVFWAVFQCSFLFGNLFVFFLFQGREQIDQHTRTILYAVLLVVGFLGLVMLVILPAMKDSDASRNTPKSEDGVVSTRGAQAPQGPLDAFLRSIKLFFTKDMGLLSVAFFYIGIEYSFLSGVYSPSIGFTLEFEDSKRLVGLSGIFIGVGEIAGGALFGILGSKTVRYGRDPIILTGFLTQALGFFLIFLNIPNNAPFGDTTDTGFITSSPFVAIFSSFLVAFGDACFNTQVYSILGGIYPNDSAPAFALFKFVSSMASAASFFYSPYIGIHPQLIIIGILLLAGTVCFWLVEWRSVYKRAHLIETSNPDSAVDKDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E9FTC4</accession>
    <name>E9FTC4_DAPPU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EOG090X0AU0</name>
        <name evidence="7" type="ORF">DAPPUDRAFT_303014</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Daphnia pulex</name>
        <name type="common">Water flea</name>
        <dbReference type="NCBI Taxonomy" id="6669"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Cornetti L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CH-H</strain>
            <strain evidence="9">PA42</strain>
            <strain evidence="10">TCO</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <dbReference type="EMBL" id="GL732524">
        <property type="protein sequence ID" value="EFX89664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR014206">
        <property type="protein sequence ID" value="SVE83825.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR014814">
        <property type="protein sequence ID" value="SVE84433.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR015430">
        <property type="protein sequence ID" value="SVE85049.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="STRING" id="6669.EFX89664"/>
    <dbReference type="EnsemblMetazoa" id="EFX89664">
        <property type="protein sequence ID" value="EFX89664"/>
        <property type="gene ID" value="DAPPUDRAFT_303014"/>
    </dbReference>
    <dbReference type="KEGG" id="dpx:DAPPUDRAFT_303014"/>
    <dbReference type="eggNOG" id="KOG2753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035254_1_0_1"/>
    <dbReference type="OMA" id="REDAQRC"/>
    <dbReference type="OrthoDB" id="679771at2759"/>
    <dbReference type="Proteomes" id="UP000000305">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="PTHR15350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="177"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
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            <title>The ecoresponsive genome of Daphnia pulex.</title>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Thomas W.K."/>
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                <person name="Shapiro H."/>
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                <person name="Smith Z."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="submission" date="2018-08" db="EMBL/GenBank/DDBJ databases">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">TCO</strain>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="99" mass="11238" checksum="352C4F414C5276C5" modified="2011-04-05" version="1">MAAEQPNLLPLVWNHLYSAQKPQCQLRSERTNGVCRCPASVLTGSPVTWLGHDHPTRLYTFNGRRDGVQSAIFADCWDSLAQLNQHLQPFKDKQKGQYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
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                <person name="Andrews J."/>
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                <person name="Lucas S.M."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="DAPPUDRAFT_305509"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="132" mass="15188" checksum="003FF86E1828DE61" modified="2011-04-05" version="1">MTWVVKTRKCKNDIAKYLEQIFLFQGMTTDALNQEEETKRLNEPIIAPIIPRELTAEEEAILDAPELSEKDLPDAELSKYLRPEVELNPVNVHLSFAANLDSDLAELEKKRTIKQQQTKKSKSKSINYLDDD</sequence>
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<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
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                <person name="Tang H."/>
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</entry>
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        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
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                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <accession>E9FXN1</accession>
    <name>E9FXN1_DAPPU</name>
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        <name type="common">Water flea</name>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
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                <person name="Schaack S."/>
                <person name="Shapiro H."/>
                <person name="Shiga Y."/>
                <person name="Skalitzky C."/>
                <person name="Smith Z."/>
                <person name="Souvorov A."/>
                <person name="Sung W."/>
                <person name="Tang Z."/>
                <person name="Tsuchiya D."/>
                <person name="Tu H."/>
                <person name="Vos H."/>
                <person name="Wang M."/>
                <person name="Wolf Y.I."/>
                <person name="Yamagata H."/>
                <person name="Yamada T."/>
                <person name="Ye Y."/>
                <person name="Shaw J.R."/>
                <person name="Andrews J."/>
                <person name="Crease T.J."/>
                <person name="Tang H."/>
                <person name="Lucas S.M."/>
                <person name="Robertson H.M."/>
                <person name="Bork P."/>
                <person name="Koonin E.V."/>
                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
                <person name="Lynch M."/>
                <person name="Boore J.L."/>
            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="4">Reversible hydration of carbon dioxide.</text>
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        <reaction evidence="4">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-carbonic anhydrase family.</text>
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    </dbReference>
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        <location>
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        <location>
            <begin position="24"/>
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        </location>
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    </evidence>
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    </evidence>
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</entry>
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    <accession>E9FYJ3</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
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                <person name="Choi J.H."/>
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                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
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                <person name="Kriventseva E.V."/>
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                <person name="Manak J.R."/>
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                <person name="Zdobnov E.M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21292972"/>
            <dbReference type="DOI" id="10.1126/science.1197761"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="14" xmlns="http://uniprot.org/uniprot">
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
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                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
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                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
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                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
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                <person name="Carmel L."/>
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                <person name="Detter J.C."/>
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                <person name="Dusheyko S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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            <begin position="84"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EFX87082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000305"/>
        </source>
    </evidence>
    <sequence length="107" mass="11586" checksum="CCC432A4E03267B5" modified="2011-04-05" version="1">MMKPEQVSVRSVITTSSLEQQQQQQQLDVDAIAEVNLSWSGRELMARLASSIDSTSLLLVDTINDQSSSAAGPSSGLITRARSLGHCRSPSSRTEYHNFHSGALAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>E9G0T8</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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            <taxon>Crustacea</taxon>
            <taxon>Branchiopoda</taxon>
            <taxon>Diplostraca</taxon>
            <taxon>Cladocera</taxon>
            <taxon>Anomopoda</taxon>
            <taxon>Daphniidae</taxon>
            <taxon>Daphnia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Science" volume="331" first="555" last="561">
            <title>The ecoresponsive genome of Daphnia pulex.</title>
            <authorList>
                <person name="Colbourne J.K."/>
                <person name="Pfrender M.E."/>
                <person name="Gilbert D."/>
                <person name="Thomas W.K."/>
                <person name="Tucker A."/>
                <person name="Oakley T.H."/>
                <person name="Tokishita S."/>
                <person name="Aerts A."/>
                <person name="Arnold G.J."/>
                <person name="Basu M.K."/>
                <person name="Bauer D.J."/>
                <person name="Caceres C.E."/>
                <person name="Carmel L."/>
                <person name="Casola C."/>
                <person name="Choi J.H."/>
                <person name="Detter J.C."/>
                <person name="Dong Q."/>
                <person name="Dusheyko S."/>
                <person name="Eads B.D."/>
                <person name="Frohlich T."/>
                <person name="Geiler-Samerotte K.A."/>
                <person name="Gerlach D."/>
                <person name="Hatcher P."/>
                <person name="Jogdeo S."/>
                <person name="Krijgsveld J."/>
                <person name="Kriventseva E.V."/>
                <person name="Kultz D."/>
                <person name="Laforsch C."/>
                <person name="Lindquist E."/>
                <person name="Lopez J."/>
                <person name="Manak J.R."/>
                <person name="Muller J."/>
                <person name="Pangilinan J."/>
                <person name="Patwardhan R.P."/>
                <person name="Pitluck S."/>
                <person name="Pritham E.J."/>
                <person name="Rechtsteiner A."/>
                <person name="Rho M."/>
                <person name="Rogozin I.B."/>
                <person name="Sakarya O."/>
                <person name="Salamov A."/>
                <person name="Schaack S."/>